Identification

Name
Bupivacaine
Accession Number
DB00297  (APRD00247)
Type
Small Molecule
Groups
Approved, Investigational
Description

A widely used local anesthetic agent. [PubChem]

Structure
Thumb
Synonyms
  • (±)-bupivacaine
  • (RS)-bupivacaine
  • 1-Butyl-2',6'-pipecoloxylidide
  • 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
  • Bupivacaina
  • Bupivacainum
  • dl-1-Butyl-2',6'-pipecoloxylidide
  • DL-Bupivacaine
  • racemic bupivacaine
External IDs
DUR-843 / LAC-43 / SKY-0402 / SKY0402
Product Ingredients
IngredientUNIICASInChI Key
Bupivacaine hydrochlorideAKA908P8J118010-40-7SIEYLFHKZGLBNX-UHFFFAOYSA-N
Bupivacaine hydrochloride monohydrate7TQO7W3VT873360-54-0HUCIWBPMHXGLFM-UHFFFAOYSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Bupivacaine HydrochlorideInjection, solution2.5 mg/mLEpidural; Infiltration; IntracaudalHospira, Inc.1978-04-172016-10-13Us
Bupivacaine HydrochlorideInjection, solution7.5 mg/mLEpidural; RetrobulbarHospira, Inc.1978-04-172016-10-13Us
Bupivacaine HydrochlorideInjection, solution5 mg/mLEpidural; Intracaudal; PerineuralHospira, Inc.1978-04-172016-11-01Us
Bupivacaine HydrochlorideInjection, solution7.5 mg/mLEpidural; RetrobulbarHospira, Inc.1978-04-172016-10-13Us
Bupivacaine HydrochlorideInjection, solution5 mg/mLEpidural; Infiltration; IntracaudalHospira, Inc.1978-04-172016-10-13Us
Bupivacaine HydrochlorideInjection, solution2.5 mg/mLEpidural; Infiltration; IntracaudalHospira, Inc.1978-04-172016-10-13Us
Bupivacaine HydrochlorideInjection, solution5 mg/mLEpidural; Intracaudal; PerineuralHospira, Inc.1978-04-172016-10-20Us
Bupivacaine Hydrochloride In Dextrose Injection USPSolution7.5 mgIntraspinalSterimax IncNot applicableNot applicableCanada
Bupivacaine Hydrochloride Injection USPSolution7.5 mgEpidural; RetrobulbarMylan PharmaceuticalsNot applicableNot applicableCanada
Bupivacaine Hydrochloride Injection USPSolution2.5 mgEpidural; InfiltrationMylan PharmaceuticalsNot applicableNot applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
BupivacaineInjection, solution7.5 mg/mLSubarachnoidHospira, Inc.1987-12-11Not applicableUs
Bupivacaine HydrochlorideInjection, solution2.5 mg/mLEpidural; Infiltration; IntracaudalCardinal Health2010-01-06Not applicableUs
Bupivacaine HydrochlorideInjection, solution5 mg/mLEpidural; IntracaudalRemedy Repack2016-06-152017-02-15Us
Bupivacaine HydrochlorideInjection, solution5 mg/mLPerineuralGeneral Injectables & Vaccines2010-07-01Not applicableUs
Bupivacaine HydrochlorideInjection, solution5 mg/mLPerineuralHospira, Inc.1987-03-03Not applicableUs
Bupivacaine HydrochlorideInjection, solution5 mg/mLEpidural; IntracaudalAuro Medics Pharma Llc2013-11-05Not applicableUs
Bupivacaine HydrochlorideInjection, solution5 mg/mLEpidural; Infiltration; IntracaudalCardinal Health2010-01-07Not applicableUs
Bupivacaine HydrochlorideInjection, solution5 mg/mLEpidural; Intracaudal; PerineuralHospira, Inc.1987-03-03Not applicableUs
Bupivacaine HydrochlorideInjection, solution7.5 mg/mLEpidural; RetrobulbarAuro Medics Pharma Llc2013-11-05Not applicableUs
Bupivacaine HydrochlorideInjection, solution2.5 mg/mLEpidural; Infiltration; Intracaudal; PerineuralHospira, Inc.1987-02-17Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Marvona SUIKInjection, solution5 mg/mLEpidural; InfiltrationAsclemed Usa, Inc.2009-09-08Not applicableUs
International/Other Brands
Bupivan (Sun) / Carbostesin (AstraZeneca) / Marcain (AstraZeneca) / Marcaina (AstraZeneca) / Sensorcaine-MPF (Astra Zeneca)
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Bupivacaine HCl 0.5% and Epinephrine 1:200,000 InjectionBupivacaine hydrochloride (5 mg) + Epinephrine bitartrate (0.0091 mg)SolutionInfiltrationNovocol Inc.2012-05-07Not applicableCanada
Bupivacaine Hydrochloride and EpinephrineBupivacaine hydrochloride (5 mg/mL) + Epinephrine bitartrate (5 ug/mL)Injection, solutionPerineuralHospira, Inc.1988-06-16Not applicableUs
Bupivacaine Hydrochloride and EpinephrineBupivacaine hydrochloride (5 mg/mL) + Epinephrine bitartrate (5 ug/mL)Injection, solutionEpidural; Intracaudal; PerineuralHospira, Inc.1988-06-16Not applicableUs
Bupivacaine Hydrochloride and EpinephrineBupivacaine hydrochloride (2.5 mg/mL) + Epinephrine bitartrate (5 ug/mL)Injection, solutionEpidural; Infiltration; Intracaudal; PerineuralGeneral Injectables & Vaccines2010-07-01Not applicableUs
Bupivacaine Hydrochloride and EpinephrineBupivacaine hydrochloride (2.5 mg/mL) + Epinephrine bitartrate (5 ug/mL)Injection, solutionEpidural; Infiltration; IntracaudalCardinal Health1988-06-16Not applicableUs
Bupivacaine Hydrochloride and EpinephrineBupivacaine hydrochloride (2.5 mg/mL) + Epinephrine bitartrate (5 ug/mL)Injection, solutionEpidural; Infiltration; Intracaudal; PerineuralHospira, Inc.1988-06-16Not applicableUs
Bupivacaine Hydrochloride and EpinephrineBupivacaine hydrochloride (2.5 mg/mL) + Epinephrine bitartrate (5 ug/mL)Injection, solutionInfiltration; PerineuralHospira, Inc.1988-06-16Not applicableUs
Bupivacaine Hydrochloride and EpinephrineBupivacaine hydrochloride (5 mg/mL) + Epinephrine bitartrate (.0091 mg/mL)Injection, solutionDental; InfiltrationHospira, Inc.1972-10-032017-10-18Us
Bupivacaine Hydrochloride and EpinephrineBupivacaine hydrochloride (2.5 mg/mL) + Epinephrine bitartrate (5 ug/mL)Injection, solutionEpidural; Infiltration; IntracaudalCardinal Health1988-06-16Not applicableUs
Disposable Convenience Kit (Single Shot Epidural)Bupivacaine (N/A N/A) + Lidocaine (N/A N/A) + Povidone-iodine (N/A N/A) + Sodium Chloride (N/A N/A)KitTrue Fit Rx Llc2016-02-04Not applicableUs
Categories
UNII
Y8335394RO
CAS number
38396-39-3
Weight
Average: 288.4277
Monoisotopic: 288.220163528
Chemical Formula
C18H28N2O
InChI Key
LEBVLXFERQHONN-UHFFFAOYSA-N
InChI
InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
IUPAC Name
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
SMILES
CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C

Pharmacology

Indication

For the production of local or regional anesthesia or analgesia for surgery, for oral surgery procedures, for diagnostic and therapeutic procedures, and for obstetrical procedures.

Structured Indications
Not Available
Pharmacodynamics

Bupivacaine is a widely used local anesthetic agent. Bupivacaine is often administered by spinal injection prior to total hip arthroplasty. It is also commonly injected into surgical wound sites to reduce pain for up to 20 hours after surgery. In comparison to other local anesthetics it has a long duration of action. It is also the most toxic to the heart when administered in large doses. This problem has led to the use of other long-acting local anaesthetics:ropivacaine and levobupivacaine. Levobupivacaine is a derivative, specifically an enantiomer, of bupivacaine. Systemic absorption of local anesthetics produces effects on the cardiovascular and central nervous systems. At blood concentrations achieved with therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal. However, toxic blood concentrations depress cardiac conduction and excitability, which may lead to atrioventricular block, ventricular arrhythmias and to cardiac arrest, sometimes resulting in fatalities. In addition, myocardial contractility is depressed and peripheral vasodilation occurs, leading to decreased cardiac output and arterial blood pressure. Following systemic absorption, local anesthetics can produce central nervous system stimulation, depression or both.

Mechanism of action

Local anesthetics such as bupivacaine block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. Bupivacaine binds to the intracellular portion of sodium channels and blocks sodium influx into nerve cells, which prevents depolarization. In general, the progression of anesthesia is related to the diameter, myelination and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: (1) pain, (2) temperature, (3) touch, (4) proprioception, and (5) skeletal muscle tone. The analgesic effects of Bupivicaine are thought to potentially be due to its binding to the prostaglandin E2 receptors, subtype EP1 (PGE2EP1), which inhibits the production of prostaglandins, thereby reducing fever, inflammation, and hyperalgesia.

TargetActionsOrganism
ASodium channel protein type 10 subunit alpha
inhibitor
Human
UProstaglandin E2 receptor EP1 subtype
other/unknown
Human
Absorption

The rate of systemic absorption of local anesthetics is dependent upon the total dose and concentration of drug administered, the route of administration, the vascularity of the administration site, and the presence or absence of epinephrine in the anesthetic solution.

Volume of distribution
Not Available
Protein binding

95%

Metabolism

Amide-type local anesthetics such as bupivacaine are metabolized primarily in the liver via conjugation with glucuronic acid. The major metabolite of bupivacaine is 2,6-pipecoloxylidine, which is mainly catalyzed via cytochrome P450 3A4.

Route of elimination

Only 6% of bupivacaine is excreted unchanged in the urine.

Half life

2.7 hours in adults and 8.1 hours in neonates

Clearance
Not Available
Toxicity

The mean seizure dosage of bupivacaine in rhesus monkeys was found to be 4.4 mg/kg with mean arterial plasma concentration of 4.5 mcg/mL. The intravenous and subcutaneous LD 50 in mice is 6 to 8 mg/kg and 38 to 54 mg/kg respectively. Recent clinical data from patients experiencing local anesthetic induced convulsions demonstrated rapid development of hypoxia, hypercarbia, and acidosis with bupivacaine within a minute of the onset of convulsions. These observations suggest that oxygen consumption and carbon dioxide production are greatly increased during local anesthetic convulsions and emphasize the importance of immediate and effective ventilation with oxygen which may avoid cardiac arrest.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Bupivacaine Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7-NitroindazoleThe risk or severity of adverse effects can be increased when Bupivacaine is combined with 7-Nitroindazole.Experimental
AbirateroneThe serum concentration of Bupivacaine can be increased when it is combined with Abiraterone.Approved
AcebutololThe serum concentration of Bupivacaine can be increased when it is combined with Acebutolol.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Aceprometazine.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Agomelatine.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Alaproclate.Experimental
AldesleukinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Aldesleukin.Approved
AlfaxaloneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Bupivacaine.Approved, Illicit
AliskirenThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Aliskiren.Approved, Investigational
AllopregnanoloneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Allopregnanolone.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Alphacetylmethadol.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Bupivacaine.Approved, Illicit, Investigational
AlprenololThe serum concentration of Bupivacaine can be increased when it is combined with Alprenolol.Approved, Withdrawn
AmifostineThe risk or severity of adverse effects can be increased when Amifostine is combined with Bupivacaine.Approved, Investigational
AmilorideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Amiloride.Approved
AmiodaroneThe metabolism of Bupivacaine can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Amitriptyline.Approved
AmlodipineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Amlodipine.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Bupivacaine.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Amperozide.Experimental
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Bupivacaine.Approved, Investigational
Amyl NitriteThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Amyl Nitrite.Approved
ApomorphineThe risk or severity of adverse effects can be increased when Apomorphine is combined with Bupivacaine.Approved, Investigational
ApraclonidineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Apraclonidine.Approved
AprepitantThe serum concentration of Bupivacaine can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleAripiprazole may increase the hypotensive activities of Bupivacaine.Approved, Investigational
ArmodafinilThe metabolism of Bupivacaine can be decreased when combined with Armodafinil.Approved, Investigational
ArotinololThe serum concentration of Bupivacaine can be increased when it is combined with Arotinolol.Approved
Arsenic trioxideThe risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Bupivacaine.Approved, Investigational
ArtemetherThe metabolism of Bupivacaine can be decreased when combined with Artemether.Approved
ArticaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Bupivacaine.Approved
AtazanavirThe metabolism of Bupivacaine can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Bupivacaine can be increased when it is combined with Atenolol.Approved
AtomoxetineThe metabolism of Bupivacaine can be decreased when combined with Atomoxetine.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Azaperone.Vet Approved
AzelastineBupivacaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Azilsartan medoxomil.Approved
AzithromycinThe metabolism of Bupivacaine can be decreased when combined with Azithromycin.Approved
BaclofenThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Baclofen.Approved
BarbexacloneBarbexaclone may increase the hypotensive activities of Bupivacaine.Experimental
BarbitalThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Barbital.Illicit
BarnidipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Bupivacaine.Approved
BefunololThe serum concentration of Bupivacaine can be increased when it is combined with Befunolol.Experimental
BenazeprilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Benazepril.Approved, Investigational
BendroflumethiazideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Bendroflumethiazide.Approved
BenperidolThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Benzocaine.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Benzyl alcohol.Approved
BepridilThe risk or severity of adverse effects can be increased when Bepridil is combined with Bupivacaine.Approved, Withdrawn
BetaxololThe serum concentration of Bupivacaine can be increased when it is combined with Betaxolol.Approved
BevantololThe serum concentration of Bupivacaine can be increased when it is combined with Bevantolol.Approved
BisoprololThe serum concentration of Bupivacaine can be increased when it is combined with Bisoprolol.Approved
BoceprevirThe metabolism of Bupivacaine can be decreased when combined with Boceprevir.Withdrawn
BopindololThe serum concentration of Bupivacaine can be increased when it is combined with Bopindolol.Approved
BortezomibThe metabolism of Bupivacaine can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Bupivacaine can be decreased when it is combined with Bosentan.Approved, Investigational
BretyliumThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Bretylium.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Brexpiprazole.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Bupivacaine.Approved, Illicit
BromisovalThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Bromisoval.Experimental
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Bupivacaine.Approved, Investigational
BromperidolThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Bromperidol.Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Brotizolam.Approved, Withdrawn
BucindololThe serum concentration of Bupivacaine can be increased when it is combined with Bucindolol.Investigational
BufuralolThe serum concentration of Bupivacaine can be increased when it is combined with Bufuralol.Experimental, Investigational
BumetanideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Bumetanide.Approved
BupranololThe serum concentration of Bupivacaine can be increased when it is combined with Bupranolol.Approved
BuprenorphineBupivacaine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupivacaine can be decreased when combined with Bupropion.Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Bupivacaine.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Bupivacaine.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Butethal.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Bupivacaine.Approved, Illicit, Vet Approved
CaffeineThe metabolism of Bupivacaine can be decreased when combined with Caffeine.Approved
CanagliflozinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Canagliflozin.Approved
CandesartanThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Candesartan.Approved
CanertinibThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Canertinib.Investigational
CaptoprilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Captopril.Approved
CarbamazepineThe metabolism of Bupivacaine can be increased when combined with Carbamazepine.Approved, Investigational
CarbetocinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Carbetocin.Approved
CarbinoxamineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Carfentanil.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Carisoprodol.Approved
CarteololThe serum concentration of Bupivacaine can be increased when it is combined with Carteolol.Approved
CarvedilolThe serum concentration of Bupivacaine can be increased when it is combined with Carvedilol.Approved, Investigational
CelecoxibThe metabolism of Bupivacaine can be decreased when combined with Celecoxib.Approved, Investigational
CeliprololThe serum concentration of Bupivacaine can be increased when it is combined with Celiprolol.Approved, Investigational
CeritinibThe serum concentration of Bupivacaine can be increased when it is combined with Ceritinib.Approved
CetirizineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChloramphenicolThe metabolism of Bupivacaine can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Bupivacaine.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chlormezanone.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chloroprocaine.Approved
ChloroquineThe metabolism of Bupivacaine can be decreased when combined with Chloroquine.Approved, Vet Approved
ChlorothiazideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chlorothiazide.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chlorphenamine.Approved
ChlorpromazineThe metabolism of Bupivacaine can be decreased when combined with Chlorpromazine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chlorprothixene.Approved, Withdrawn
ChlorthalidoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chlorthalidone.Approved
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chlorzoxazone.Approved
CholecalciferolThe metabolism of Bupivacaine can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CilazaprilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Cilazapril.Approved
CilnidipineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Cilnidipine.Approved
CimetidineThe metabolism of Bupivacaine can be decreased when combined with Cimetidine.Approved
CinacalcetThe metabolism of Bupivacaine can be decreased when combined with Cinacalcet.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Cinchocaine.Approved, Vet Approved
CitalopramThe metabolism of Bupivacaine can be decreased when combined with Citalopram.Approved
ClarithromycinThe metabolism of Bupivacaine can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Bupivacaine can be decreased when combined with Clemastine.Approved
ClevidipineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Clevidipine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Clidinium.Approved
ClobazamThe metabolism of Bupivacaine can be decreased when combined with Clobazam.Approved, Illicit
ClofarabineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Clofarabine.Approved, Investigational
clomethiazoleThe risk or severity of adverse effects can be increased when Bupivacaine is combined with clomethiazole.Investigational
ClomipramineThe metabolism of Bupivacaine can be decreased when combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Clonidine.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Clopenthixol.Experimental
CloranololThe serum concentration of Bupivacaine can be increased when it is combined with Cloranolol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Bupivacaine.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Clothiapine.Experimental
ClotrimazoleThe metabolism of Bupivacaine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Bupivacaine can be decreased when combined with Clozapine.Approved
CobicistatThe serum concentration of Bupivacaine can be increased when it is combined with Cobicistat.Approved
CocaineThe metabolism of Bupivacaine can be decreased when combined with Cocaine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Bupivacaine.Approved, Illicit
ConivaptanThe serum concentration of Bupivacaine can be increased when it is combined with Conivaptan.Approved, Investigational
CrizotinibThe metabolism of Bupivacaine can be decreased when combined with Crizotinib.Approved
CyclizineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Bupivacaine.Approved
CyclosporineThe metabolism of Bupivacaine can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Cyproheptadine.Approved
Cyproterone acetateThe serum concentration of Bupivacaine can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
DabrafenibThe serum concentration of Bupivacaine can be decreased when it is combined with Dabrafenib.Approved
DantroleneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dantrolene.Approved
DapagliflozinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dapagliflozin.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dapiprazole.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dapoxetine.Investigational
DarifenacinThe metabolism of Bupivacaine can be decreased when combined with Darifenacin.Approved, Investigational
DarunavirThe serum concentration of Bupivacaine can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Bupivacaine can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of Bupivacaine can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Bupivacaine can be decreased when combined with Delavirdine.Approved
DeramciclaneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Bupivacaine.Approved
DesipramineThe metabolism of Bupivacaine can be decreased when combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dexmedetomidine.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dextropropoxyphene.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dezocine.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Bupivacaine.Approved, Illicit, Vet Approved
DiclofenamideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Diclofenamide.Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Diethyl ether.Experimental
DifenoxinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Bupivacaine.Approved, Illicit
DihydroergotamineThe metabolism of Bupivacaine can be decreased when combined with Dihydroergotamine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dihydromorphine.Experimental, Illicit
DiltiazemThe metabolism of Bupivacaine can be decreased when combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dimenhydrinate.Approved
DinutuximabThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dinutuximab.Approved
DiphenhydramineThe metabolism of Bupivacaine can be decreased when combined with Diphenhydramine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Bupivacaine.Approved, Illicit
DipyridamoleThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dipyridamole.Approved
DixyrazineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dixyrazine.Experimental
DoramectinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Doramectin.Vet Approved
DosulepinThe metabolism of Bupivacaine can be decreased when combined with Dosulepin.Approved
DoxazosinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Doxazosin.Approved
DoxepinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Doxepin.Approved
DoxycyclineThe metabolism of Bupivacaine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Bupivacaine is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.Approved, Illicit
DronedaroneThe metabolism of Bupivacaine can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Drotebanol.Experimental, Illicit
DuloxetineBupivacaine may increase the orthostatic hypotensive activities of Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dyclonine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ecgonine.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Efavirenz.Approved, Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Efonidipine.Approved
EliglustatThe metabolism of Bupivacaine can be decreased when combined with Eliglustat.Approved
EltanoloneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Eltanolone.Investigational
EmpagliflozinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Empagliflozin.Approved
EnalaprilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Enalaprilat.Approved
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Bupivacaine.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Entacapone.Approved, Investigational
EnzalutamideThe serum concentration of Bupivacaine can be decreased when it is combined with Enzalutamide.Approved
EpanololThe serum concentration of Bupivacaine can be increased when it is combined with Epanolol.Experimental
EplerenoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Eplerenone.Approved
EpoprostenolThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Epoprostenol.Approved
EprosartanThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Eprosartan.Approved
ErythromycinThe metabolism of Bupivacaine can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe metabolism of Bupivacaine can be decreased when combined with Eslicarbazepine acetate.Approved
EsmololThe serum concentration of Bupivacaine can be increased when it is combined with Esmolol.Approved
EsomeprazoleThe metabolism of Bupivacaine can be decreased when combined with Esomeprazole.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Bupivacaine.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Bupivacaine.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Etacrynic acid.Approved
EthanolBupivacaine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Bupivacaine.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ethyl carbamate.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ethyl chloride.Experimental
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ethylmorphine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Bupivacaine.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Etorphine.Illicit, Vet Approved
EtravirineThe metabolism of Bupivacaine can be decreased when combined with Etravirine.Approved
EzogabineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Felbamate.Approved
FelodipineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Felodipine.Approved, Investigational
FencamfamineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Fencamfamine.Approved, Illicit, Withdrawn
FenoldopamThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Fenoldopam.Approved
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Bupivacaine.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Fexofenadine.Approved
FimasartanThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Fimasartan.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Flibanserin.Approved
FluanisoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Fluanisone.Experimental
FluconazoleThe metabolism of Bupivacaine can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Flunitrazepam.Approved, Illicit
FluoxetineThe metabolism of Bupivacaine can be decreased when combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Bupivacaine.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Bupivacaine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Bupivacaine.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Fluspirilene.Approved
Fluticasone propionateThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Fluticasone propionate.Approved
FluvoxamineThe metabolism of Bupivacaine can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Bupivacaine can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Bupivacaine can be increased when it is combined with Fosaprepitant.Approved
FosinoprilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Fosinopril.Approved
FosphenytoinThe metabolism of Bupivacaine can be increased when combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Fospropofol.Approved, Illicit
FurosemideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Furosemide.Approved, Vet Approved
Fusidic AcidThe serum concentration of Bupivacaine can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Bupivacaine.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Gabapentin Enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Bupivacaine.Approved, Illicit
GemfibrozilThe metabolism of Bupivacaine can be decreased when combined with Gemfibrozil.Approved
GepironeThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Glutethimide.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Halazepam.Approved, Illicit, Withdrawn
HaloperidolThe metabolism of Bupivacaine can be decreased when combined with Haloperidol.Approved
HalothaneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Halothane.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Heroin.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Hexobarbital.Approved
HyaluronidaseThe risk or severity of adverse effects can be increased when Hyaluronidase is combined with Bupivacaine.Approved, Investigational
HydralazineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Hydralazine.Approved
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneBupivacaine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydroflumethiazideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Hydroflumethiazide.Approved
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Bupivacaine.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.Approved
IdelalisibThe serum concentration of Bupivacaine can be increased when it is combined with Idelalisib.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Iloperidone.Approved
IloprostThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Iloprost.Approved, Investigational
ImatinibThe metabolism of Bupivacaine can be decreased when combined with Imatinib.Approved
ImidaprilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Imidapril.Investigational
ImipramineThe metabolism of Bupivacaine can be decreased when combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Indalpine.Investigational, Withdrawn
IndapamideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Indapamide.Approved
IndenololThe serum concentration of Bupivacaine can be increased when it is combined with Indenolol.Withdrawn
IndinavirThe metabolism of Bupivacaine can be decreased when combined with Indinavir.Approved
IndiplonThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Indiplon.Investigational
IndoraminThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Indoramin.Withdrawn
IrbesartanThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Irbesartan.Approved, Investigational
IsavuconazoniumThe metabolism of Bupivacaine can be decreased when combined with Isavuconazonium.Approved, Investigational
IsocarboxazidThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Isocarboxazid.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Bupivacaine.Approved, Vet Approved
IsoniazidThe metabolism of Bupivacaine can be decreased when combined with Isoniazid.Approved
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Isosorbide Dinitrate.Approved
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Isosorbide Mononitrate.Approved
IsoxsuprineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Isoxsuprine.Approved, Withdrawn
IsradipineThe metabolism of Bupivacaine can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Bupivacaine can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Bupivacaine can be increased when it is combined with Ivacaftor.Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Bupivacaine.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ketobemidone.Approved
KetoconazoleThe metabolism of Bupivacaine can be decreased when combined with Ketoconazole.Approved, Investigational
LabetalolThe serum concentration of Bupivacaine can be increased when it is combined with Labetalol.Approved
LacidipineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Lacidipine.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Lamotrigine.Approved, Investigational
LandiololThe serum concentration of Bupivacaine can be increased when it is combined with Landiolol.Investigational
LercanidipineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Lercanidipine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Levetiracetam.Approved, Investigational
LevobunololThe serum concentration of Bupivacaine can be increased when it is combined with Levobunolol.Approved
LevobupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Levobupivacaine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Levocetirizine.Approved
LevodopaBupivacaine may increase the orthostatic hypotensive activities of Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Levomethadyl Acetate.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Bupivacaine.Approved
LevosimendanThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Levosimendan.Approved, Investigational
LidocaineThe metabolism of Bupivacaine can be decreased when combined with Lidocaine.Approved, Vet Approved
LisinoprilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Lisinopril.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Lithium.Approved
LobeglitazoneThe metabolism of Bupivacaine can be decreased when combined with Lobeglitazone.Approved
LofentanilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Lofentanil.Illicit
LofexidineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Lofexidine.Approved, Investigational
LopinavirThe metabolism of Bupivacaine can be decreased when combined with Lopinavir.Approved
LoprazolamThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Loprazolam.Experimental
LoratadineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Bupivacaine.Approved
LorcaserinThe metabolism of Bupivacaine can be decreased when combined with Lorcaserin.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Lormetazepam.Approved
LosartanThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Losartan.Approved
LovastatinThe metabolism of Bupivacaine can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Bupivacaine.Approved
LuliconazoleThe serum concentration of Bupivacaine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Bupivacaine can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe metabolism of Bupivacaine can be decreased when combined with Lumefantrine.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Bupivacaine.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.Approved, Vet Approved
ManidipineThe metabolism of Bupivacaine can be decreased when combined with Manidipine.Approved
MannitolThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Mannitol.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Maprotiline.Approved
MebicarThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Mebicar.Experimental
MecamylamineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Mecamylamine.Approved
MeclizineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Meclizine.Approved
MedazepamThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Melatonin.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Melperone.Approved
MepindololThe serum concentration of Bupivacaine can be increased when it is combined with Mepindolol.Experimental
MepivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Mepivacaine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Bupivacaine.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Meptazinol.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Mesoridazine.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Metaxalone.Approved
MethadoneThe metabolism of Bupivacaine can be decreased when combined with Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Methadyl Acetate.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Methaqualone.Illicit, Withdrawn
MethazolamideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Methazolamide.Approved
MethocarbamolThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Bupivacaine.Approved
MethotrimeprazineBupivacaine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Methoxyflurane.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Methsuximide.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Methyclothiazide.Approved
MethyldopaThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Methyldopa.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Methylecgonine.Experimental
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Methylphenobarbital.Approved
MetipranololThe serum concentration of Bupivacaine can be increased when it is combined with Metipranolol.Approved
MetolazoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Metolazone.Approved
MetoprololThe serum concentration of Bupivacaine can be increased when it is combined with Metoprolol.Approved, Investigational
MetyrosineBupivacaine may increase the sedative activities of Metyrosine.Approved
MexiletineThe metabolism of Bupivacaine can be decreased when combined with Mexiletine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Bupivacaine.Approved, Illicit
MidostaurinThe metabolism of Bupivacaine can be decreased when combined with Midostaurin.Approved
MifepristoneThe serum concentration of Bupivacaine can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.Approved, Investigational
MinoxidilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Minoxidil.Approved
MirabegronThe metabolism of Bupivacaine can be decreased when combined with Mirabegron.Approved
MirtazapineBupivacaine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of Bupivacaine can be decreased when it is combined with Mitotane.Approved
MoclobemideThe metabolism of Bupivacaine can be decreased when combined with Moclobemide.Approved
ModafinilThe metabolism of Bupivacaine can be decreased when combined with Modafinil.Approved, Investigational
MoexiprilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Moexipril.Approved
MolindoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Molindone.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Bupivacaine.Approved, Investigational
MoxonidineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Moxonidine.Approved
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.Approved, Investigational
NadololThe serum concentration of Bupivacaine can be increased when it is combined with Nadolol.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Bupivacaine.Approved
NebivololThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Nebivolol.Approved, Investigational
NefazodoneThe metabolism of Bupivacaine can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Bupivacaine can be decreased when combined with Nelfinavir.Approved
NesiritideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Nesiritide.Approved, Investigational
NetupitantThe serum concentration of Bupivacaine can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Bupivacaine can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Bupivacaine can be decreased when combined with Nicardipine.Approved
NicorandilNicorandil may increase the hypotensive activities of Bupivacaine.Approved
NifedipineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Nifedipine.Approved
NilotinibThe metabolism of Bupivacaine can be decreased when combined with Nilotinib.Approved, Investigational
NilvadipineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Nilvadipine.Approved
NimodipineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Nimodipine.Approved
NisoldipineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Nisoldipine.Approved
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Bupivacaine.Approved
NitrendipineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Nitrendipine.Approved
Nitric OxideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Nitric Oxide.Approved
NitroglycerinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Nitroglycerin.Approved, Investigational
NitroprussideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Nitroprusside.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Bupivacaine.Approved, Vet Approved
NorfluraneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Norflurane.Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Nortriptyline.Approved
ObinutuzumabThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Obinutuzumab.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Bupivacaine.Approved, Investigational
OlaparibThe metabolism of Bupivacaine can be decreased when combined with Olaparib.Approved
OlmesartanThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Olmesartan.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Olopatadine.Approved
OmeprazoleThe metabolism of Bupivacaine can be decreased when combined with Omeprazole.Approved, Investigational, Vet Approved
OndansetronThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ondansetron.Approved
OpiumThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Opium.Approved, Illicit
OrphenadrineBupivacaine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Osanetant.Investigational
OsimertinibThe serum concentration of Bupivacaine can be increased when it is combined with Osimertinib.Approved
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Bupivacaine.Approved
OxethazaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Oxethazaine.Investigational
OxprenololThe serum concentration of Bupivacaine can be increased when it is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Oxybuprocaine.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Bupivacaine.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Bupivacaine.Approved, Investigational, Vet Approved
PaclitaxelThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Paclitaxel.Approved, Vet Approved
PalbociclibThe serum concentration of Bupivacaine can be increased when it is combined with Palbociclib.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Bupivacaine.Approved
PanobinostatThe serum concentration of Bupivacaine can be increased when it is combined with Panobinostat.Approved, Investigational
PantoprazoleThe metabolism of Bupivacaine can be decreased when combined with Pantoprazole.Approved
PapaverineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Papaverine.Approved
ParaldehydeBupivacaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe metabolism of Bupivacaine can be decreased when combined with Paroxetine.Approved, Investigational
Peginterferon alfa-2bThe serum concentration of Bupivacaine can be decreased when it is combined with Peginterferon alfa-2b.Approved
PenbutololThe serum concentration of Bupivacaine can be increased when it is combined with Penbutolol.Approved, Investigational
PenfluridolThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Penfluridol.Experimental
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Bupivacaine.Approved, Vet Approved
PentobarbitalThe metabolism of Bupivacaine can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.Approved
PerazineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Perazine.Investigational
PerindoprilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Perindopril.Approved
PerospironeThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Bupivacaine.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Bupivacaine.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Phenazocine.Experimental
PhenelzineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Phenelzine.Approved
PhenibutThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Phenibut.Experimental
PhenobarbitalThe metabolism of Bupivacaine can be increased when combined with Phenobarbital.Approved
PhenoperidineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Phenoperidine.Experimental
PhenoxybenzamineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Phenoxybenzamine.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Phenoxyethanol.Approved
PhentolamineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Phentolamine.Approved
PhenytoinThe metabolism of Bupivacaine can be increased when combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Bupivacaine.Approved
PindololThe serum concentration of Bupivacaine can be increased when it is combined with Pindolol.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Pipamperone.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Pomalidomide.Approved
PosaconazoleThe metabolism of Bupivacaine can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PractololThe serum concentration of Bupivacaine can be increased when it is combined with Practolol.Approved
PramipexoleBupivacaine may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Prazepam.Approved, Illicit
PrazosinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Prazosin.Approved
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Bupivacaine.Approved, Illicit, Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Prilocaine.Approved
PrimidoneThe metabolism of Bupivacaine can be increased when combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Procaine.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Bupivacaine.Approved, Vet Approved
PromazineThe metabolism of Bupivacaine can be decreased when combined with Promazine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Promethazine.Approved
PropanididThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Propanidid.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Proparacaine.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Bupivacaine.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Propoxycaine.Approved
PropranololThe serum concentration of Bupivacaine can be increased when it is combined with Propranolol.Approved, Investigational
ProtriptylineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Protriptyline.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when Bupivacaine is combined with PSD502.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Bupivacaine.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Bupivacaine.Approved
QuinaprilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Quinapril.Approved, Investigational
QuinidineThe metabolism of Bupivacaine can be decreased when combined with Quinidine.Approved
QuinineThe metabolism of Bupivacaine can be decreased when combined with Quinine.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ramelteon.Approved, Investigational
RamiprilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ramipril.Approved
RanolazineThe metabolism of Bupivacaine can be decreased when combined with Ranolazine.Approved, Investigational
RasagilineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Rasagiline.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Bupivacaine.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Remoxipride.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Bupivacaine.Approved
RifabutinThe metabolism of Bupivacaine can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Bupivacaine can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Bupivacaine can be increased when combined with Rifapentine.Approved
RiociguatThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Riociguat.Approved
RisperidoneBupivacaine may increase the hypotensive activities of Risperidone.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ritanserin.Investigational
RitonavirThe metabolism of Bupivacaine can be decreased when combined with Ritonavir.Approved, Investigational
RolapitantThe metabolism of Bupivacaine can be decreased when combined with Rolapitant.Approved
RomifidineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Romifidine.Vet Approved
RopiniroleBupivacaine may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Bupivacaine.Approved
RotigotineBupivacaine may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Bupivacaine.Approved
SacubitrilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Sacubitril.Approved
SaquinavirThe metabolism of Bupivacaine can be decreased when combined with Saquinavir.Approved, Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Bupivacaine.Approved, Vet Approved
SelegilineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Selegiline.Approved, Investigational, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Sepranolone.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Sertindole.Approved, Withdrawn
SertralineThe metabolism of Bupivacaine can be decreased when combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Bupivacaine.Approved, Vet Approved
SildenafilThe metabolism of Bupivacaine can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Bupivacaine can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Bupivacaine can be increased when it is combined with Simeprevir.Approved
Sodium NitriteThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Sodium Nitrite.Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.Approved
SotalolThe serum concentration of Bupivacaine can be increased when it is combined with Sotalol.Approved
SpironolactoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Bupivacaine can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Bupivacaine can be increased when it is combined with Stiripentol.Approved
StreptokinaseThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Streptokinase.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Bupivacaine.Approved, Investigational
SulfisoxazoleThe metabolism of Bupivacaine can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Sulpiride.Approved
SultoprideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Sultopride.Experimental
SuvorexantBupivacaine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TalinololThe serum concentration of Bupivacaine can be increased when it is combined with Talinolol.Investigational
TamsulosinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tamsulosin.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tasimelteon.Approved
Technetium Tc-99m tilmanoceptBupivacaine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.Approved
TelaprevirThe metabolism of Bupivacaine can be decreased when combined with Telaprevir.Withdrawn
TelithromycinThe metabolism of Bupivacaine can be decreased when combined with Telithromycin.Approved
TelmisartanThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Telmisartan.Approved, Investigational
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Bupivacaine.Approved
Tenofovir disoproxilThe metabolism of Bupivacaine can be decreased when combined with Tenofovir disoproxil.Approved, Investigational
TerazosinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Terazosin.Approved
TerbinafineThe metabolism of Bupivacaine can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TeriflunomideThe serum concentration of Bupivacaine can be decreased when it is combined with Teriflunomide.Approved
TertatololThe serum concentration of Bupivacaine can be increased when it is combined with Tertatolol.Experimental
TetrabenazineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tetracaine.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tetrahydropalmatine.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tetrodotoxin.Investigational
ThalidomideBupivacaine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Bupivacaine can be decreased when combined with Theophylline.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Thiamylal.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Thiopental.Approved, Vet Approved
ThioridazineThe metabolism of Bupivacaine can be decreased when combined with Thioridazine.Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Bupivacaine.Approved
TiagabineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tiapride.Approved, Investigational
TiclopidineThe metabolism of Bupivacaine can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tilidine.Experimental
TimololThe serum concentration of Bupivacaine can be increased when it is combined with Timolol.Approved
TipranavirThe metabolism of Bupivacaine can be decreased when combined with Tipranavir.Approved, Investigational
TizanidineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tizanidine.Approved
TocilizumabThe serum concentration of Bupivacaine can be decreased when it is combined with Tocilizumab.Approved
TolazolineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tolazoline.Approved, Vet Approved
TolcaponeThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Topiramate.Approved
TorasemideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Torasemide.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Bupivacaine.Approved, Investigational
TrandolaprilThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Trandolapril.Approved
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe metabolism of Bupivacaine can be decreased when combined with Tranylcypromine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Trazodone.Approved, Investigational
TretinoinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tretinoin.Approved, Investigational, Nutraceutical
TriamtereneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Triamterene.Approved
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Bupivacaine.Approved
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Tricaine methanesulfonate.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Trichloroethylene.Experimental
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Bupivacaine.Approved
TrifluperidolThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Triflupromazine.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Triprolidine.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Valproic Acid.Approved, Investigational
ValsartanThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Valsartan.Approved, Investigational
VemurafenibThe serum concentration of Bupivacaine can be increased when it is combined with Vemurafenib.Approved
VenlafaxineThe metabolism of Bupivacaine can be decreased when combined with Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Veralipride.Experimental
VerapamilThe metabolism of Bupivacaine can be decreased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Vigabatrin.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Vinyl ether.Experimental
VoriconazoleThe metabolism of Bupivacaine can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Vortioxetine.Approved
XenonThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Xenon.Experimental
XylazineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Bupivacaine.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Bupivacaine can be decreased when combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Zolazepam.Vet Approved
ZolpidemBupivacaine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Bupivacaine.Approved
ZotepineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Zotepine.Approved
ZucapsaicinThe metabolism of Bupivacaine can be decreased when combined with Zucapsaicin.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Bupivacaine.Approved, Investigational
Food Interactions
Not Available

References

Synthesis Reference

Thuresson, B. and Egner, B.P.H.; U.S. Patent 2,792,399; May 14, 1957; assigned to AB Bofors, Sweden. Thuresson, B. and Pettersson, B.G.; US. Patent 2,955.1 11; October 4,1960; assigned to AB Bofors, Sweden.

US2955111
General References
  1. Rosenblatt MA, Abel M, Fischer GW, Itzkovich CJ, Eisenkraft JB: Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology. 2006 Jul;105(1):217-8. [PubMed:16810015]
  2. Picard J, Meek T: Lipid emulsion to treat overdose of local anaesthetic: the gift of the glob. Anaesthesia. 2006 Feb;61(2):107-9. [PubMed:16430560]
  3. Link [Link]
External Links
Human Metabolome Database
HMDB14442
KEGG Compound
C07529
PubChem Compound
2474
PubChem Substance
46506768
ChemSpider
2380
BindingDB
50350790
ChEBI
77431
ChEMBL
CHEMBL1098
Therapeutic Targets Database
DAP001229
PharmGKB
PA135057240
IUPHAR
2397
Guide to Pharmacology
GtP Drug Page
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Bupivacaine
ATC Codes
N01BB51 — Bupivacaine, combinationsN01BB01 — Bupivacaine
AHFS Codes
  • 72:00.00 — Local Anesthetics
FDA label
Download (147 KB)
MSDS
Download (73.3 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingSupportive CareHemorrhoids / Perianal Fistulas1
0Active Not RecruitingTreatmentCHRONIC POST-TRAUMATIC NEUROPATHIC PAIN IN ANKLE AND FOOT1
0CompletedNot AvailableTibial Plateau Fracture1
0CompletedSupportive CareMenopausal Hot Flushes1
0Enrolling by InvitationTreatmentPain1
0Not Yet RecruitingDiagnosticVasoplegia1
0Not Yet RecruitingTreatmentOsteoarthritis of the Hands1
0RecruitingOtherCaudal epidural block therapy1
0RecruitingTreatmentPain1
0RecruitingTreatmentPostdural Puncture Headache1
0TerminatedOtherPain1
0Unknown StatusPreventionPostoperative pain1
1CompletedNot AvailableSafety of Neosaxitoxin in Healthy Volunteers1
1CompletedBasic SciencePain, Acute1
1CompletedDiagnosticCaudal Block1
1CompletedHealth Services ResearchCoarctation of the Aorta1
1CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections1
1CompletedSupportive CarePostoperative Pain Management1
1CompletedSupportive CarePostoperative pain1
1CompletedTreatmentCerebral Vasospasm1
1CompletedTreatmentFusion of Spine (Disease) / Pain Management1
1CompletedTreatmentHealthy Volunteers1
1CompletedTreatmentLower Abdominal Surgery1
1CompletedTreatmentPostoperative pain1
1Not Yet RecruitingSupportive CareLocal Anesthesia / Neoplasms, Brain1
1RecruitingSupportive CareBalanitis / Paraphimosis / Phimosis / Postoperative pain1
1RecruitingSupportive CareCancer of Pancreas / Cancer of the Pancreas / Malignant Neoplasm of Pancreas / Pancreas Neoplasms1
1TerminatedPreventionPostoperative pain1
1TerminatedTreatmentRotator Cuff Syndrome1
1Unknown StatusPreventionPostoperative pain1
1, 2CompletedTreatmentAnalgesia, Postoperative1
1, 2CompletedTreatmentElective Laparoscopic Cholecystectomy1
1, 2CompletedTreatmentPostoperative pain1
1, 2RecruitingTreatmentGeneral Surgery / Pelvic Organ Prolapse (POP) / Postoperative pain1
1, 2RecruitingTreatmentImmune System Suppression1
1, 2RecruitingTreatmentMigraines1
1, 2WithdrawnTreatmentFoley Catheter Discomfort / Prostate Cancer / Robotic Prostatectomy1
1, 2WithdrawnTreatmentLower Extremity Fractures1
2Active Not RecruitingTreatmentPosterior Fossa Tumors1
2CompletedNot AvailablePostoperative pain1
2CompletedOtherHernioplasty1
2CompletedPreventionAdverse Anesthesia Outcome1
2CompletedPreventionArterial Hypotension1
2CompletedPreventionCoagulation Defect; Bleeding1
2CompletedPreventionHeadaches1
2CompletedPreventionPostoperative pain1
2CompletedPreventionRotator Cuff Syndrome1
2CompletedSupportive CareCholesteatoma / Cochlear Implants / Mastoidectomy / Tympanomastoid Surgery1
2CompletedSupportive CareMucositis1
2CompletedSupportive CarePostoperative pain3
2CompletedTreatmentAnaesthesia therapy1
2CompletedTreatmentAnalgesia in Patients With Inguinal Herniorrhaphy1
2CompletedTreatmentBunions1
2CompletedTreatmentChronic Low Back Pain (CLBP)1
2CompletedTreatmentCoronary Artery Disease / Postoperative pain1
2CompletedTreatmentInguinal Hernias1
2CompletedTreatmentLow Back Pain (LBP)1
2CompletedTreatmentObesity, Morbid / Postoperative pain1
2CompletedTreatmentPain1
2CompletedTreatmentPain / Postoperative1
2CompletedTreatmentPain / Tooth Extractions1
2CompletedTreatmentPost Operative Local Anaesthesia1
2CompletedTreatmentPostoperative pain4
2Not Yet RecruitingSupportive CareAnaesthesia therapy / Block / General Surgery / Thoracic Injury1
2Not Yet RecruitingSupportive CareCaudal Block1
2Not Yet RecruitingSupportive CareMenopausal Hot Flushes / Vasomotor Symptoms1
2Not Yet RecruitingTreatmentArthroplasty / Knee / Replacement1
2Not Yet RecruitingTreatmentFemoral Fractures1
2RecruitingDiagnosticPain1
2RecruitingPreventionForearm Surgeries1
2RecruitingPreventionLaparoscopic Orcheopexy1
2RecruitingPreventionPostoperative pain1
2RecruitingSupportive CareCancer of Breast / Cancer, Breast / Malignant Neoplasm of Female Breast1
2RecruitingSupportive CareMammaplasty1
2RecruitingSupportive CareMenopausal Hot Flushes1
2RecruitingSupportive CareMenopausal Hot Flushes / Vasomotor Symptoms1
2RecruitingTreatmentAbdominal Pain (AP)1
2RecruitingTreatmentCancer, Breast1
2RecruitingTreatmentInjuries, Ankle1
2RecruitingTreatmentIntrathecal Dexmedetomidine / Pediatric Cancer Surgery1
2RecruitingTreatmentLacrimation increased / Procidentia1
2RecruitingTreatmentNeoplasms, Breast1
2RecruitingTreatmentPain, Acute1
2RecruitingTreatmentPost-Operative Pain1
2RecruitingTreatmentPostoperative pain1
2TerminatedTreatmentAppendicitis1
2TerminatedTreatmentBenign Headache1
2TerminatedTreatmentPain, Chronic1
2TerminatedTreatmentPostoperative Hemorrhages / Postoperative pain1
2TerminatedTreatmentPostoperative pain1
2Unknown StatusDiagnosticPersistent Pain After Breast Cancer Surgery1
2Unknown StatusSupportive CareIncisional Hernias / Postoperative Complications / Postoperative pain / Umbilical Hernias / Ventral Hernias1
2Unknown StatusTreatmentShoulder Surgery1
2, 3Active Not RecruitingTreatmentInguinal Hernias / Postoperative pain / Umbilical Hernias1
2, 3Active Not RecruitingTreatmentPain Management / Therapies1
2, 3Active Not RecruitingTreatmentPostoperative pain2
2, 3CompletedPreventionHypospadias1
2, 3CompletedPreventionRecovery After Cleft Palate Surgery1
2, 3CompletedTreatmentPostoperative pain5
2, 3Not Yet RecruitingTreatmentLocal Anesthetics Causing Adverse Effects in Therapeutic Use / Opioid Dependence / Postoperative pain / Thoracic Diseases1
2, 3Not Yet RecruitingTreatmentPain1
2, 3Not Yet RecruitingTreatmentPain, Acute1
2, 3RecruitingPreventionPostoperative pain1
2, 3RecruitingTreatmentEsotropia / Exotropia / Graves Diseases / Nystagmus / Strabismus1
2, 3RecruitingTreatmentNeoplasms, Lung1
2, 3RecruitingTreatmentPain1
2, 3RecruitingTreatmentPlantar fascial fibromatosis1
2, 3RecruitingTreatmentPost Surgical Pain1
2, 3RecruitingTreatmentPostoperative pain1
2, 3SuspendedPreventionAnaesthesia therapy1
2, 3TerminatedPreventionShoulder Surgery1
2, 3TerminatedTreatmentCREST Syndrome / Diffuse Systemic Sclerosis / Peripheral Vascular Disease (PVD) / Raynaud's Disease1
2, 3TerminatedTreatmentUmbilical Hernias1
2, 3Unknown StatusSupportive CareStillborn Caesarean Section2
2, 3Unknown StatusTreatmentOsteoarthritis of Hip1
2, 3WithdrawnTreatmentDegenerative Arthritis / Degenerative Joint Disease / Osteoarthritis of the Knees / Osteoarthrosis Deformans / Synovitis of osteoarthritis1
3Active Not RecruitingHealth Services ResearchAbdominal Cancer1
3Active Not RecruitingTreatmentGynecologic Cancers / Malignant Neoplasms of Female Genital Organs1
3Active Not RecruitingTreatmentPain / Synovitis of osteoarthritis1
3Active Not RecruitingTreatmentPost Operative Pain1
3CompletedNot AvailableHernioplasty1
3CompletedPreventionPost-operative Pain for Total Knee Arthroplasty1
3CompletedSupportive CareHemorrhoids1
3CompletedSupportive CarePostoperative pain1
3CompletedSupportive CareSubtenon Anesthesia1
3CompletedTreatmentAbdominal Surgeries / Postoperative pain1
3CompletedTreatmentBiceps Tendonitis1
3CompletedTreatmentBunions / Hallux Valgus1
3CompletedTreatmentCancer, Breast1
3CompletedTreatmentDental Pain1
3CompletedTreatmentFunctional Endoscopic Sinus Surgery (FESS)1
3CompletedTreatmentHeadaches / Migraines1
3CompletedTreatmentHemorrhoids1
3CompletedTreatmentInguinal Hernias / Pain, Chronic1
3CompletedTreatmentLaparoscopic Colecctomy1
3CompletedTreatmentPostoperative pain4
3CompletedTreatmentRadicular syndrome1
3CompletedTreatmentSpinal Anaesthesia1
3Enrolling by InvitationTreatmentInguinal Hernias1
3Not Yet RecruitingDiagnosticCancer, Breast / Pain / Pain, Neuropathic1
3Not Yet RecruitingPreventionAnalgesia1
3Not Yet RecruitingPreventionMalignant Neoplasm of Female Breast1
3Not Yet RecruitingSupportive CarePostoperative pain1
3Not Yet RecruitingTreatmentAnaesthesia therapy1
3Not Yet RecruitingTreatmentBreech Presentation1
3Not Yet RecruitingTreatmentCoronary Artery Disease / Coronary Artery Stenoses / Valve Regurgitation, Mitral / Valve Regurgitation, Tricuspid1
3Not Yet RecruitingTreatmentPain, Chronic1
3Not Yet RecruitingTreatmentPostoperative pain / Renal Stones1
3RecruitingDiagnosticNeurocostal neuralgia / Peripheral Neuropathic Pain1
3RecruitingPreventionAnalgesia1
3RecruitingPreventionFracture, Ankle / Local Infiltration / Postoperative pain1
3RecruitingSupportive CareBreast - Female1
3RecruitingSupportive CareLaparoscopic TAP Block in TEP Inguinal Hernia Repair1
3RecruitingTreatmentArterial Hypotension / Pain / Pregnant Women1
3RecruitingTreatmentCesarean Section1
3RecruitingTreatmentDiseases of Liver1
3RecruitingTreatmentFemoral Fractures1
3RecruitingTreatmentFracture, Ankle1
3RecruitingTreatmentGynecologic Cancers / Post Operative Pain1
3RecruitingTreatmentHip Injuries1
3RecruitingTreatmentInguinal Hernias / Local Anesthesia / Sedation, Conscious1
3RecruitingTreatmentPain3
3RecruitingTreatmentPostoperative pain1
3TerminatedSupportive CarePain1
3TerminatedTreatmentInjury of Anterior Cruciate Ligament1
3TerminatedTreatmentPain1
3TerminatedTreatmentPostoperative pain1
3Unknown StatusTreatmentCancer, Breast1
3Unknown StatusTreatmentOsteoarthritis, Hip1
3Unknown StatusTreatmentPain Score and Number of PCA Bolus Used by Patients1
3WithdrawnPreventionProphylaxis against postoperative nausea and vomiting1
3WithdrawnSupportive CareCesarean Delivery1
3WithdrawnSupportive CareFracture of Lower Limb1
3WithdrawnTreatmentDisorder of Rotator Cuff / Disorder of Shoulder / Disorder of Tendon of Biceps / Injury of Shoulder Region / Shoulder Pain1
3WithdrawnTreatmentLabour Pain1
3WithdrawnTreatmentOrthopedic Disorder of Spine1
4Active Not RecruitingPreventionRupture of Anterior Cruciate Ligament1
4Active Not RecruitingTreatmentArthritis1
4Active Not RecruitingTreatmentDisorder of Shoulder / Postoperative pain1
4Active Not RecruitingTreatmentHip Fractures1
4Active Not RecruitingTreatmentPain2
4Active Not RecruitingTreatmentPostoperative pain / Shoulder Arthritis1
4CompletedNot AvailableEnd Stage Liver Diseases / Lung Cancers1
4CompletedNot AvailableHemorrhoids / Peri Anal Fistula1
4CompletedNot AvailablePain1
4CompletedNot AvailablePostoperative pain1
4CompletedBasic SciencePeriarticular Block / Serum Bupivacaine Level / Total Knee Arthroplasty (TKA)1
4CompletedHealth Services ResearchArthroplasty, Replacement, Knee / Pain1
4CompletedHealth Services ResearchIntestinal Obstruction1
4CompletedHealth Services ResearchRetraction of Colostomy1
4CompletedOtherPain1
4CompletedPreventionAnaesthesia / Toxicity1
4CompletedPreventionApplication Site Discomfort / Medical Device Discomfort1
4CompletedPreventionArterial Hypotension1
4CompletedPreventionHypnotic / Specified Sedative1
4CompletedPreventionPostoperative Hemorrhages / Postoperative pain1
4CompletedPreventionPostoperative pain1
4CompletedPreventionRetinal Detachment / Retinoschisis / Vitreoretinopathy, Proliferative1
4CompletedSupportive CareBMI >30 kg/m2 / General Surgery / Neuromuscular Inhibition / Pain1
4CompletedSupportive CareDiverticulitis / Malignant Neoplasm of Colon / Post-Operative Pain1
4CompletedSupportive CareLumbar Spine Disc Herniation1
4CompletedSupportive CareObstetric Pain1
4CompletedSupportive CarePelvic Organ Prolapse (POP)1
4CompletedSupportive CareQuality of Ocular Akinesia (Onset and Duration)1
4CompletedSupportive CareThe Duration of Motor Block for Sciatic Block Following TKR May Vary Between 12-36 Hrs Depending on the Amount of Local Anesthetic Given1
4CompletedTreatmentAbdominal/ Donor Site / DIEP or Free MS-TRAM Breast Reconstruction / Local Pain Management / Transversus Abdominis Plane (TAP) Block Catheter1
4CompletedTreatmentAmbulatory Surgical Procedures / Arthroplasty, Replacement, Knee / Early Ambulation / Pain Management / Spinal Anaesthesia1
4CompletedTreatmentAmputation Stumps / Neuroma1
4CompletedTreatmentAnaesthesia therapy1
4CompletedTreatmentAnalgesia After ACL Reconstruction1
4CompletedTreatmentAnalgesia / Postsurgical Pain / Prostatectomy1
4CompletedTreatmentAnkle Arthrodesis / Hindfoot Arthrodesis / Tibitalocalceal Arthrodesis1
4CompletedTreatmentAnterior Cruciate Ligament Rupture1
4CompletedTreatmentArterial Hypotension / Cardiac Output / Spinal Anaesthesia1
4CompletedTreatmentArterial Hypotension / Cesarean Section / Pregnancy / Spinal Anaesthesia1
4CompletedTreatmentArthropathy of Knee Joint / Postoperative pain1
4CompletedTreatmentArthroplasty, Replacement, Knee1
4CompletedTreatmentArthroplasty, Replacement, Knee / Complications; Arthroplasty / Knee Injuries1
4CompletedTreatmentAtypical Facial Pain / Typical Facial Pain1
4CompletedTreatmentBMI >30 kg/m21
4CompletedTreatmentBimalleolar Fractures of the Ankle / Post Operative Analgesia Duration / Saphenous Nerve Block / Sciatic Nerve Block1
4CompletedTreatmentBrachial Plexus Blockade1
4CompletedTreatmentCarpal Tunnel Syndrome (CTS) / Trigger Finger1
4CompletedTreatmentCervical Intraepithelial Neoplasia (CIN)1
4CompletedTreatmentCesarean Section / Prophylaxis against postoperative nausea and vomiting / Spinal Anaesthesia1
4CompletedTreatmentChronic Migraine1
4CompletedTreatmentComplication of Anesthesia1
4CompletedTreatmentDexmedetomidine in Subarachnoidal Anesthesia1
4CompletedTreatmentFracture of Shoulder and Upper Arm1
4CompletedTreatmentGall Stone Disease1
4CompletedTreatmentHallux Valgus1
4CompletedTreatmentHernia1
4CompletedTreatmentHip Injuries / Painful musculoskeletal conditions1
4CompletedTreatmentHypertensive1
4CompletedTreatmentInternal Derangement of Knee1
4CompletedTreatmentKnee Replacement Surgery / Post Operative Pain1
4CompletedTreatmentKnee Surgery / Postoperative pain1
4CompletedTreatmentLabour Pain1
4CompletedTreatmentMeniscus Lesion1
4CompletedTreatmentMigrainous Headache1
4CompletedTreatmentNasal Surgery1
4CompletedTreatmentOpen Reduction Internal Fixation(ORIF) of Lateral Malleolus1
4CompletedTreatmentOsteoarthritis of the Knees2
4CompletedTreatmentOsteoarthritis, Hip1
4CompletedTreatmentPain10
4CompletedTreatmentPain Management1
4CompletedTreatmentPain, Acute4
4CompletedTreatmentPain / Shoulder Arthroscopy1
4CompletedTreatmentPercutaneous Nephrolithotomy1
4CompletedTreatmentPost Operative Urinary Retention1
4CompletedTreatmentPost-Operative Pain2
4CompletedTreatmentPostoperative pain6
4CompletedTreatmentPostoperative pain / Spine Disease1
4CompletedTreatmentPostoperative pain / Surgical Procedure, Unspecified1
4CompletedTreatmentAdjunct to general anesthesia therapy / Propofol Target-controlled Infusion / Thoracic Epidural Anesthesia1
4CompletedTreatmentRotator Cuff Syndrome / Shoulder Pain1
4CompletedTreatmentScoliosis1
4CompletedTreatmentSequelae of Fracture of Forearm and Upper Arm1
4CompletedTreatmentSpinal Anaesthesia1
4CompletedTreatmentSurgical Procedures, Operative1
4CompletedTreatmentSurgical Remove of Hemorrhoids1
4CompletedTreatmentThyroidectomy1
4CompletedTreatmentToothache1
4CompletedTreatmentTotal Hip Arthroplasty (THA)1
4CompletedTreatmentTotal Knee Arthroplasty (TKA)2
4CompletedTreatmentUrinary Incontinence,Stress1
4CompletedTreatmentSynovitis of osteoarthritis1
4Enrolling by InvitationPreventionLaparoscopic Cholecystectomy1
4Enrolling by InvitationSupportive CareCaudal Block1
4Enrolling by InvitationTreatmentAnesthesia Complication / Hemodynamics Instability / Ileus paralytic / Nausea / Postoperative pain / Vomiting1
4Enrolling by InvitationTreatmentPain1
4Enrolling by InvitationTreatmentPain Following Thoracotomy Surgery1
4Enrolling by InvitationTreatmentPost-Operative Pain / Tonsillectomy / Tonsillitis1
4Enrolling by InvitationTreatmentTotal Hip Arthroplasty (THA)1
4Not Yet RecruitingNot AvailableAdverse Reaction to Spinal Anesthetic / Maternal Care for Cervical Incompetence1
4Not Yet RecruitingNot AvailableForearm Injuries / Injuries, Hand1
4Not Yet RecruitingOtherComplex Regional Pain Syndromes (CRPS) / Shoulder Hand Syndrome1
4Not Yet RecruitingPreventionCesarean Section Complications2
4Not Yet RecruitingPreventionCesarean Section Complications / Spinal Anaesthesia1
4Not Yet RecruitingPreventionMigraine Disorders1
4Not Yet RecruitingPreventionNonvalvular Atrial Fibrillation1
4Not Yet RecruitingTreatmentAcromioclavicular Joint Resection / Acromioplasty / Arthroscopic Shoulder Surgery / Intra-articular Debridement / Subacromial Decompression1
4Not Yet RecruitingTreatmentActivity, Sexual / Analgesics, Non-Narcotic / Analgesics, Opioid / Patients Satisfaction / Peripheral Nervous System Agents / Physiological Effects of Drugs / Postoperative pain / Return to Work1
4Not Yet RecruitingTreatmentAnaesthetic complication neurological / Anesthesia; Adverse Effect, Spinal and Epidural1
4Not Yet RecruitingTreatmentBariatric Surgery Candidate / Postoperative pain1
4Not Yet RecruitingTreatmentCervical incompetence1
4Not Yet RecruitingTreatmentCesarean Section / Pain, Neuropathic / Postoperative pain1
4Not Yet RecruitingTreatmentHysterectomy1
4Not Yet RecruitingTreatmentPain1
4RecruitingPreventionAnaesthesia therapy / Bupivacaine / Hip Pain Chronic1
4RecruitingPreventionAnaesthesia therapy / Hip Fractures1
4RecruitingPreventionCesarean Delivery1
4RecruitingPreventionCesarean Section Complications1
4RecruitingPreventionCesarean Section Complications / Spinal Anaesthesia2
4RecruitingPreventionEndometrial Adenocarcinomas1
4RecruitingPreventionPain1
4RecruitingScreeningObstetrical Anesthesia1
4RecruitingSupportive CareColon Diverticulosis / Colonic Neoplasms / Constipation Drug Induced / Diverticulitis, Colonic / Ileus / Ileus paralytic / Ileus; Mechanical / Malignant Neoplasm of Colon / Occasional Constipation / Postoperative pain / Rectum Cancer / Rectum Neoplasm1
4RecruitingSupportive CarePostoperative pain1
4RecruitingSupportive CarePregnancy1
4RecruitingSupportive CareRotator Cuff Syndrome1
4RecruitingTreatmentAnterior Cruciate Ligament Injury1
4RecruitingTreatmentAortic Valve Disorder / Atrial Septal Defect (ASD) / Diseases of Mitral Valve / Intracardiac Myxoma1
4RecruitingTreatmentBreakthrough Pain / Pain, Chronic / Pain, Intractable1
4RecruitingTreatmentCaesarean Sections / Pain Management1
4RecruitingTreatmentCesarean Section / Pain Management / Pain, Neuropathic1
4RecruitingTreatmentChest Injury Trauma / Drug Effect / Intercostal Rib / Local Anesthesia / Local Infiltration / Nerve Pain / Opioid Dependence / Pain; Catheter (Other) / Pneumonia / Rib Fractures / Rib Trauma / Surgical Procedure, Unspecified1
4RecruitingTreatmentClavicle Fractures1
4RecruitingTreatmentClosed Fracture of Hip1
4RecruitingTreatmentExternal Cephalic Version1
4RecruitingTreatmentHeadaches1
4RecruitingTreatmentHip Fractures1
4RecruitingTreatmentHysterectomy1
4RecruitingTreatmentInguinal Hernias / Postoperative pain1
4RecruitingTreatmentMigraines1
4RecruitingTreatmentOsteoarthritis of the Knees1
4RecruitingTreatmentOsteoarthritis, Hip2
4RecruitingTreatmentPain3
4RecruitingTreatmentPain, Acute1
4RecruitingTreatmentPain, Acute / Regional Anesthesia Morbidity1
4RecruitingTreatmentPain / Pregnancy1
4RecruitingTreatmentPost Operative Pain (Post Laparoscopic Hernia Repair)1
4RecruitingTreatmentPost-operative Pain Management1
4RecruitingTreatmentPostoperative Pain Management1
4RecruitingTreatmentPostoperative Pain Score1
4RecruitingTreatmentPostoperative pain7
4RecruitingTreatmentPostoperative pain / Total Knee Arthroplasty (TKA)1
4RecruitingTreatmentSurgery, Colorectal / TAP Blocks1
4RecruitingTreatmentUrinary Tract Diseases1
4RecruitingTreatmentSynovitis of osteoarthritis1
4SuspendedNot AvailableOnset and Duration of a Digital Nerve Block1
4TerminatedDiagnosticSI Joint Pain1
4TerminatedHealth Services ResearchIntestinal Obstruction3
4TerminatedSupportive CareFoot Surgery / Fracture of Foot1
4TerminatedTreatmentACL Repair / Bankart Repair / Meniscectomy1
4TerminatedTreatmentCardiac Diseases1
4TerminatedTreatmentFracture of Neck of Femur1
4TerminatedTreatmentHemorrhoids1
4TerminatedTreatmentPain3
4TerminatedTreatmentPostoperative pain2
4TerminatedTreatmentPostsurgical Analgesia1
4TerminatedTreatmentShoulder Pain1
4Unknown StatusNot AvailableAnesthesia Conduction / Anesthetics, Local / Injuries, Hand1
4Unknown StatusPreventionPain1
4Unknown StatusSupportive CareTonsillectomy1
4Unknown StatusTreatmentCesarean Section / Local Anaesthetics Causing Adverse Effects in Therapeutic Use / Spinal Anaesthesia1
4Unknown StatusTreatmentDuration of Pain Relief2
4Unknown StatusTreatmentEpidural Block / Labour / Pregnancy / Primigravida Labour1
4Unknown StatusTreatmentFracture of Neck of Femur1
4Unknown StatusTreatmentInfraclavicular Brachial Plexus Block1
4Unknown StatusTreatmentInguinal Hernias1
4Unknown StatusTreatmentPain Control of Distal Radius Fractures With Liposomal Bupivacaine Injection1
4Unknown StatusTreatmentPost Minimally Invasive Thorascopic Surgical Pain1
4Unknown StatusTreatmentSpinal Anaesthesia1
4WithdrawnSupportive CareFracture Bone / Lower Limb Injuries1
4WithdrawnSupportive CarePain Management / Total Knee Arthroplasty (TKA)1
4WithdrawnTreatmentAnalgesia Duration1
4WithdrawnTreatmentArthroplasty, Replacement, Knee / Osteoarthritis of the Knees1
4WithdrawnTreatmentArthroplasty, Replacement, Knee / Postoperative pain / Synovitis of osteoarthritis1
4WithdrawnTreatmentBursitis1
4WithdrawnTreatmentHip Fractures1
4WithdrawnTreatmentOsteoarthritis of the Knees1
4WithdrawnTreatmentPain2
4WithdrawnTreatmentTotal Knee Arthroplasty (TKA)1
4WithdrawnTreatmentVentral Hernias1
Not AvailableActive Not RecruitingNot AvailableKnee Pain Arthritis1
Not AvailableActive Not RecruitingHealth Services ResearchPostoperative Complications1
Not AvailableActive Not RecruitingSupportive CareMalignant Neoplasm of Pancreas1
Not AvailableActive Not RecruitingSupportive CarePostoperative Complications1
Not AvailableActive Not RecruitingTreatmentCervial Disc Herniation / Cervical Disc Herniation / Prolapsed Lumbar Disc1
Not AvailableActive Not RecruitingTreatmentMotor Impairments / Neurological Conditions / Orthopaedic Injury1
Not AvailableActive Not RecruitingTreatmentOsteoarthritis of the Knees1
Not AvailableActive Not RecruitingTreatmentPost-Operative Pain1
Not AvailableActive Not RecruitingTreatmentRib Fractures1
Not AvailableCompletedNot AvailableAdverse Effects / Anaesthesia therapy / Cesarean Section / Transversus Abdominis Plane Block1
Not AvailableCompletedNot AvailableAmbulatory Surgical Procedures / Inguinal Hernias / Spinal Anaesthesia / Umbilical Hernias1
Not AvailableCompletedNot AvailableAnaesthesia therapy / Maternal Hypotension1
Not AvailableCompletedNot AvailableBlood Pressures / Feeling Anxious1
Not AvailableCompletedNot AvailableEpilepsies1
Not AvailableCompletedNot AvailableInfiltration Facet Joint1
Not AvailableCompletedNot AvailableInterstitial Cystitis/Painful Bladder Syndrome / Myofascial Pelvic Pain1
Not AvailableCompletedNot AvailableKnee Replacement Surgery1
Not AvailableCompletedNot AvailablePain2
Not AvailableCompletedNot AvailablePostoperative pain1
Not AvailableCompletedNot AvailableRenal Failure1
Not AvailableCompletedNot AvailableRhytidoplasty1
Not AvailableCompletedNot AvailableSpinal Anaesthesia / Total Knee Replacement Arthroplasty1
Not AvailableCompletedBasic SciencePain1
Not AvailableCompletedDiagnosticParesis1
Not AvailableCompletedOtherOsteoarthritis of the Knees1
Not AvailableCompletedOtherPain / Postoperative pain1
Not AvailableCompletedPreventionGeneral Surgery1
Not AvailableCompletedPreventionLiver Cancer1
Not AvailableCompletedPreventionPain1
Not AvailableCompletedPreventionPostoperative pain1
Not AvailableCompletedPreventionPostoperative pain / Wisdom Tooth1
Not AvailableCompletedSupportive CareAnaesthesia therapy / Cataract Unilateral Pending Extraction1
Not AvailableCompletedSupportive CareColorectal Disease1
Not AvailableCompletedSupportive CareInflammatory Reaction / Postoperative pain1
Not AvailableCompletedSupportive CareLabour Pain1
Not AvailableCompletedSupportive CareLaparoscopic Gynecologic Surgery / Paracervical Block / Postoperative pain1
Not AvailableCompletedSupportive CarePain Insensitivity, Congenital1
Not AvailableCompletedSupportive CarePost-traumatic; Arthrosis / Synovitis of osteoarthritis1
Not AvailableCompletedSupportive CareRotator Cuff Syndrome1
Not AvailableCompletedSupportive CareTotal Knee Arthroplasty (TKA)1
Not AvailableCompletedTreatmentAbdominal Cancer1
Not AvailableCompletedTreatmentAnalgesia / Thyroid Diseases1
Not AvailableCompletedTreatmentBreastfeeding / Pain1
Not AvailableCompletedTreatmentCancer, Breast / Postoperative pain1
Not AvailableCompletedTreatmentCerebral Palsy (CP) / Postoperative pain1
Not AvailableCompletedTreatmentCesarean Delivery1
Not AvailableCompletedTreatmentChronic Low Back Pain (CLBP)1
Not AvailableCompletedTreatmentColorectal Cancers1
Not AvailableCompletedTreatmentDiaphragm Paralysis1
Not AvailableCompletedTreatmentElbow Fractures1
Not AvailableCompletedTreatmentFracture Bone / Pain1
Not AvailableCompletedTreatmentFracture, Ankle1
Not AvailableCompletedTreatmentGall Stone Pancreatitis / Gallbladder Inflammation1
Not AvailableCompletedTreatmentGall Stones1
Not AvailableCompletedTreatmentGastric Adenoma / Malignant Neoplasm of Stomach1
Not AvailableCompletedTreatmentGeneral Surgery / Malignant Neoplasm of Abdomen1
Not AvailableCompletedTreatmentHemorrhoids1
Not AvailableCompletedTreatmentInjury of Shoulder Region1
Not AvailableCompletedTreatmentInterscalene Block / Shoulder Arthroscopy1
Not AvailableCompletedTreatmentLabour Pain4
Not AvailableCompletedTreatmentLow Back Pain (LBP)1
Not AvailableCompletedTreatmentMyofascial Pain Syndromes1
Not AvailableCompletedTreatmentOsteoarthritis of the Knees1
Not AvailableCompletedTreatmentOsteoarthritis of the Knees / Osteoarthritis, Hip / Osteoarthritis, Shoulder1
Not AvailableCompletedTreatmentOsteoarthritis: Joint Replacement Surgery1
Not AvailableCompletedTreatmentPain6
Not AvailableCompletedTreatmentPain, Acute1
Not AvailableCompletedTreatmentGallstone formation / Pain1
Not AvailableCompletedTreatmentPenile Surgery1
Not AvailableCompletedTreatmentPost Operative Pain1
Not AvailableCompletedTreatmentPost Surgical Pain1
Not AvailableCompletedTreatmentPostoperative pain3
Not AvailableCompletedTreatmentProximal Femur Fractures1
Not AvailableCompletedTreatmentShoulder Arthroscopy1
Not AvailableCompletedTreatmentSpinal Anaesthesia1
Not AvailableCompletedTreatmentStress Urinary Incontinence (SUI)1
Not AvailableCompletedTreatmentThe Analgesic Effects1
Not AvailableCompletedTreatmentTotal Knee Arthroplasty (TKA)1
Not AvailableCompletedTreatmentUmbilical Hernias1
Not AvailableCompletedTreatmentVentral Hernias1
Not AvailableCompletedTreatmentLumbar epidural anesthesia1
Not AvailableCompletedTreatmentSynovitis of osteoarthritis2
Not AvailableEnrolling by InvitationNot AvailableArthritis / Gout Acute / Headaches / Migraines / Muscle Spasms / Radicular syndrome / Synovitis / Tendonitis1
Not AvailableEnrolling by InvitationNot AvailableCancer, Breast / Pain1
Not AvailableEnrolling by InvitationNot AvailablePelvic Organ Prolapse (POP) / Postoperative pain1
Not AvailableEnrolling by InvitationSupportive CareFemoral Fractures / Postoperative pain1
Not AvailableEnrolling by InvitationTreatmentEye Enucleation / Eye Evisceration1
Not AvailableEnrolling by InvitationTreatmentGoiter, Nodular / Graves' Disease / Hyperparathyroidism / Neoplasms, Thyroid / Thyroid Nodules1
Not AvailableEnrolling by InvitationTreatmentLow Back Pain (LBP)1
Not AvailableNot Yet RecruitingNot AvailableKnee Replacement Surgery / Pain1
Not AvailableNot Yet RecruitingPreventionBilateral Superficial Cervical Block1
Not AvailableNot Yet RecruitingSupportive CareRectus Sheath Block1
Not AvailableNot Yet RecruitingTreatmentAnaesthesia therapy1
Not AvailableNot Yet RecruitingTreatmentAnaesthesia therapy / Cancers / Pain1
Not AvailableNot Yet RecruitingTreatmentAnalgesia / Aspiration / Pain / Tibial Fractures1
Not AvailableNot Yet RecruitingTreatmentCancer, Breast / Mastectomy / Post Operative Pain / Regional Anesthesia1
Not AvailableNot Yet RecruitingTreatmentInguinal Hernias1
Not AvailableNot Yet RecruitingTreatmentInterscalene Block / Regional Anesthesia / Shoulder Surgery1
Not AvailableNot Yet RecruitingTreatmentPostoperative Recovery / Transurethral Resection of the Bladder / Urinary Bladder Neoplasms1
Not AvailableNot Yet RecruitingTreatmentPostoperative pain2
Not AvailableNot Yet RecruitingTreatmentPrimary Osteoarthritis of Knee Nos1
Not AvailableNot Yet RecruitingTreatmentRegional Anesthesia1
Not AvailableRecruitingNot AvailableAnalgesia / Anesthetics / Pain Management1
Not AvailableRecruitingNot AvailableArthroplasty, Replacement, Knee / Postoperative pain1
Not AvailableRecruitingNot AvailableRenal Failure1
Not AvailableRecruitingDiagnosticLumbar Disc Disease1
Not AvailableRecruitingPreventionArterial Hypotension1
Not AvailableRecruitingPreventionFracture of Proximal Femur1
Not AvailableRecruitingPreventionLabour Pain / Postpartum Depression1
Not AvailableRecruitingPreventionPostoperative pain2
Not AvailableRecruitingPreventionSwallowing Disorders1
Not AvailableRecruitingSupportive CareLumbar Laminectomy1
Not AvailableRecruitingSupportive CareSynovitis of osteoarthritis1
Not AvailableRecruitingTreatmentAbdominal Wall Defects1
Not AvailableRecruitingTreatmentArthropathy / Closed Fracture Proximal Humerus, Four Part / Shoulder Pain / Synovitis of osteoarthritis1
Not AvailableRecruitingTreatmentArthroplasty, Replacement, Knee / Caudal epidural block therapy1
Not AvailableRecruitingTreatmentConditions Requiring Colorectal Surgery1
Not AvailableRecruitingTreatmentCaudal epidural block therapy / Herniorrhaphy / Regional Anesthesia1
Not AvailableRecruitingTreatmentHip Fractures1
Not AvailableRecruitingTreatmentHip Injuries1
Not AvailableRecruitingTreatmentInguinal Herniorrhaphy1
Not AvailableRecruitingTreatmentKnee Arthropathy1
Not AvailableRecruitingTreatmentLabour Analgesia1
Not AvailableRecruitingTreatmentLabour Pain1
Not AvailableRecruitingTreatmentLaparoscopic Appendectomy1
Not AvailableRecruitingTreatmentMajor Abdominal Surgery / Postoperative pain1
Not AvailableRecruitingTreatmentPost Operative Pain1
Not AvailableRecruitingTreatmentPostoperative pain2
Not AvailableRecruitingTreatmentPregnancy1
Not AvailableRecruitingTreatmentRadius Fractures1
Not AvailableRecruitingTreatmentRupture of Anterior Cruciate Ligament / Tear of Anterior Cruciate Ligament1
Not AvailableTerminatedOtherAbdominal Wall Relaxation After Rectus Sheath Block / Hernia / Postoperative pain1
Not AvailableTerminatedPreventionAbdominal Surgeries1
Not AvailableTerminatedPreventionSecondary Hyperalgesia1
Not AvailableTerminatedSupportive CareBunions / Hallux Rigidus1
Not AvailableTerminatedTreatmentLabour Pain1
Not AvailableTerminatedTreatmentPain1
Not AvailableTerminatedTreatmentPost-Operative Pain1
Not AvailableUnknown StatusNot AvailableAnalgesia1
Not AvailableUnknown StatusNot AvailablePain1
Not AvailableUnknown StatusNot AvailableTotal Knee Arthroplasty (TKA)1
Not AvailableUnknown StatusDiagnosticAnesthesia, Spinal [E03.155.086.331] / Operating Tables [E07.325.662]1
Not AvailableUnknown StatusHealth Services ResearchLocal Anesthesia / Satisfaction1
Not AvailableUnknown StatusPreventionPain1
Not AvailableUnknown StatusSupportive CareLocal Anesthesia1
Not AvailableUnknown StatusSupportive CarePain1
Not AvailableUnknown StatusTreatmentAnalgesia1
Not AvailableUnknown StatusTreatmentAnalgesia / Postoperative pain1
Not AvailableUnknown StatusTreatmentBlock1
Not AvailableUnknown StatusTreatmentLumbar Plexus Nerve Block / Osteoarthritis of Hip / Other Acute Postoperative Pain / Parasacaral (Sciatic) Nerve Block / Peripheral Nerve Blocks / Regional Anesthesia / Total Hip Arthroplasty (THA)1
Not AvailableUnknown StatusTreatmentPain3
Not AvailableUnknown StatusTreatmentPost Operative Pain1
Not AvailableUnknown StatusTreatmentPostoperative pain1
Not AvailableWithdrawnHealth Services ResearchFemoroacetabular Impingement1
Not AvailableWithdrawnPreventionVaginal Delivery1
Not AvailableWithdrawnSupportive CarePelvic Organ Prolapse (POP)1
Not AvailableWithdrawnTreatmentPain After Carpal Tunnel Release1
Not AvailableWithdrawnTreatmentPostdural Puncture Headache / Sphenopalatine Ganglion Block1

Pharmacoeconomics

Manufacturers
  • Hospira inc
  • International medicated systems ltd
  • App pharmaceuticals llc
Packagers
Dosage forms
FormRouteStrength
Injection, solutionEpidural; Infiltration; Intracaudal2.5 mg/mL
Injection, solutionEpidural; Infiltration; Intracaudal5 mg/mL
Injection, solutionEpidural; Infiltration; Intracaudal; Perineural2.5 mg/mL
Injection, solutionEpidural; Intracaudal5 mg/mL
Injection, solutionEpidural; Intracaudal; Perineural5 mg/mL
Injection, solutionEpidural; Retrobulbar7.5 mg/mL
Injection, solutionInfiltration; Perineural2.5 mg/mL
Injection, solutionIntraspinal7.5 mg/mL
Injection, solutionDental; Infiltration
Injection, solutionEpidural; Infiltration; Intracaudal
SolutionIntraspinal7.5 mg
SolutionEpidural; Infiltration2.5 mg
SolutionEpidural; Infiltration5 mg
SolutionEpidural; Retrobulbar7.5 mg
SolutionInfiltration2.5 mg
SolutionInfiltration5 mg
SolutionEpidural; Infiltration; Intracaudal2.5 mg
SolutionEpidural; Infiltration; Intracaudal5 mg
SolutionEpidural; Infiltration; Intracaudal7.5 mg
Injection, suspension, liposomalInfiltration13.3 mg/mL
Injection, solutionEpidural
KitTopical
Injection, solutionEpidural5 mg/mL
Injection, solutionEpidural; Infiltration2.5 mg/mL
Injection, solutionInfiltration2.5 mg/mL
SolutionEpidural; Retrobulbar150 mg
SolutionInfiltration
SolutionInfiltration125 mg
SolutionInfiltration250 mg
LiquidEpidural; Infiltration2.5 mg
LiquidInfiltration
LiquidEpidural; Infiltration5 mg
LiquidEpidural; Retrobulbar7.5 mg
LiquidIntraspinal7.5 mg
LiquidEpidural; Infiltration
SolutionIntraspinal15 mg
Injection, solutionInfiltration
Injection, solutionEpidural; Infiltration5 mg/mL
Kit
KitEpidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; Topical
KitEpidural; Infiltration; Intramuscular; Intravenous
KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue
KitEpidural; Infiltration
KitEpidural; Infiltration; Intra-articular; Intramuscular; Topical
Injection, solutionInfiltration; Perineural
Injection, solutionPerineural
Injection, solutionPerineural5 mg/mL
Injection, solutionEpidural; Infiltration; Intracaudal; Perineural
Injection, solutionEpidural; Intracaudal; Perineural
Injection, solutionEpidural; Retrobulbar
Injection, solutionSubarachnoid7.5 mg/mL
SolutionEpidural; Infiltration
Injection, solutionSubcutaneous
Prices
Unit descriptionCostUnit
Bupivacaine hcl powder18.36USD g
Sensorcaine-dextr 0.75% amp2.36USD ml
Marcaine spinal ampul0.93USD ml
Bupivacaine 0.5% on-q pump0.63USD ml
Bupivacaine hcl 0.5% on-q pump0.63USD ml
Bupivacaine 0.25% on-q pump0.62USD ml
Marcaine 0.25% vial0.26USD ml
Bupivacaine hcl-ns 0.0625%0.25USD ml
Bupivacaine-ns 0.1% on-q pump0.25USD ml
Sensorcaine 0.25% vial0.2USD ml
Bupivacaine hcl-ns 0.1%0.17USD ml
Bupivacaine hcl-ns 0.2%0.15USD ml
Bupivacaine 0.25% vial0.11USD ml
Bupivacaine 0.25% ampul0.1USD ml
Bupivacaine hcl-ns 0.125% bag0.1USD ml
Bupivacaine hcl-ns 0.25%0.1USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US8182835No1998-09-182018-09-18Us
US8834921No1998-09-182018-09-18Us
US9205052No1998-09-182018-09-18Us
US9585838No2001-12-242021-12-24Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)107-108 °CPhysProp
water solubility2400 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP3.41HANSCH,C ET AL. (1995)
pKa8.1Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0977 mg/mLALOGPS
logP3.31ALOGPS
logP4.52ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)13.62ChemAxon
pKa (Strongest Basic)8ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area32.34 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity90.19 m3·mol-1ChemAxon
Polarizability34.19 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9814
Blood Brain Barrier+0.936
Caco-2 permeable+0.6669
P-glycoprotein substrateSubstrate0.8435
P-glycoprotein inhibitor IInhibitor0.8582
P-glycoprotein inhibitor IINon-inhibitor0.7836
Renal organic cation transporterNon-inhibitor0.6471
CYP450 2C9 substrateNon-substrate0.7957
CYP450 2D6 substrateSubstrate0.8346
CYP450 3A4 substrateSubstrate0.7045
CYP450 1A2 substrateInhibitor0.6863
CYP450 2C9 inhibitorNon-inhibitor0.9099
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorInhibitor0.6205
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.6066
Ames testNon AMES toxic0.8462
CarcinogenicityNon-carcinogens0.8859
BiodegradationNot ready biodegradable0.9729
Rat acute toxicity2.2574 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8283
hERG inhibition (predictor II)Inhibitor0.7851
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (8.44 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-000i-0290000000-c1dbebb634be5e7e1140
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0006-0910000000-ae34de204bcb9a9deb23
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0006-0900000000-7ea7001506aae0c271a0
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0006-2900000000-ef819c5e235d6d524d8c
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0006-7900000000-22d7491053c05d773e93
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-001l-9400000000-71357b8186126c5933ce

Taxonomy

Description
This compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Alpha amino acid amides
Alternative Parents
Piperidinecarboxamides / Anilides / m-Xylenes / N-arylamides / Trialkylamines / Secondary carboxylic acid amides / Azacyclic compounds / Organopnictogen compounds / Organic oxides / Hydrocarbon derivatives
show 1 more
Substituents
Alpha-amino acid amide / 2-piperidinecarboxamide / Piperidinecarboxamide / Anilide / M-xylene / Xylene / N-arylamide / Monocyclic benzene moiety / Benzenoid / Piperidine
show 16 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
piperidinecarboxamide, tertiary amino compound, aromatic amide (CHEBI:77431)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Voltage-gated sodium channel activity
Specific Function
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference acro...
Gene Name
SCN10A
Uniprot ID
Q9Y5Y9
Uniprot Name
Sodium channel protein type 10 subunit alpha
Molecular Weight
220623.605 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Sheets MF, Fozzard HA, Lipkind GM, Hanck DA: Sodium channel molecular conformations and antiarrhythmic drug affinity. Trends Cardiovasc Med. 2010 Jan;20(1):16-21. doi: 10.1016/j.tcm.2010.03.002. [PubMed:20685573]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Other/unknown
General Function
Prostaglandin e receptor activity
Specific Function
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an importa...
Gene Name
PTGER1
Uniprot ID
P34995
Uniprot Name
Prostaglandin E2 receptor EP1 subtype
Molecular Weight
41800.655 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Beloeil H, Gentili M, Benhamou D, Mazoit JX: The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats. Anesth Analg. 2009 Sep;109(3):943-50. doi: 10.1213/ane.0b013e3181aff25e. [PubMed:19690271]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Gantenbein M, Attolini L, Bruguerolle B, Villard PH, Puyoou F, Durand A, Lacarelle B, Hardwigsen J, Le-Treut YP: Oxidative metabolism of bupivacaine into pipecolylxylidine in humans is mainly catalyzed by CYP3A. Drug Metab Dispos. 2000 Apr;28(4):383-5. [PubMed:10725304]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Drug created on June 13, 2005 07:24 / Updated on October 21, 2017 09:35