Acute Lymphocytic Leukemia (ALL)

Also known as: Acute Lymphocytic Leukemia / Acute Lymphoid Leukemia (ALL) / Acute Lymphatic Leukemia / Acute Lymphocytic Leukaemia / Acute Lymphoid Leukemia / Acute lymphoblastic leukemia with failed remission / Acute lymphoblastic leukaemia / Leukemia lymphoblastic acute / Acute lymphoblastic leukemia / Lymphoid leukaemia, acute / Acute lymphoid leukaemia / Lymphoid leukemia, acute / ALL / Leukaemia lymphoblastic acute / Acute lymphatic leukaemia / Leukaemias acute lymphocytic

DrugDrug NameDrug Description
DB00987CytarabineA pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
DB00694DaunorubicinA very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. [PubChem]
DB00563MethotrexateAn antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
DB01204MitoxantroneAn anthracenedione-derived antineoplastic agent. [PubChem]
DrugDrug NameTargetType
DB00987CytarabineDNA polymerase betatarget
DB00987CytarabineCytidine deaminaseenzyme
DB00987CytarabineSolute carrier family 22 member 2transporter
DB00987CytarabineSolute carrier family 22 member 1transporter
DB00987CytarabineMultidrug resistance-associated protein 7transporter
DB00987CytarabineEquilibrative nucleoside transporter 1transporter
DB00987CytarabineDNAtarget
DB00987CytarabineCytochrome P450 3A4enzyme
DB00987CytarabineDeoxycytidine kinaseenzyme
DB00987Cytarabine5'-nucleotidaseenzyme
DB00987CytarabineDeoxycytidylate deaminaseenzyme
DB00694DaunorubicinDNAtarget
DB00694DaunorubicinXanthine dehydrogenase/oxidaseenzyme
DB00694DaunorubicinCytochrome P450 3A5enzyme
DB00694DaunorubicinNADPH--cytochrome P450 reductaseenzyme
DB00694DaunorubicinMultidrug resistance protein 1transporter
DB00694DaunorubicinMultidrug resistance-associated protein 1transporter
DB00694DaunorubicinCanalicular multispecific organic anion transporter 1transporter
DB00694DaunorubicinSolute carrier family 22 member 2transporter
DB00694DaunorubicinMultidrug resistance-associated protein 6transporter
DB00694DaunorubicinBile salt export pumptransporter
DB00694DaunorubicinMultidrug resistance-associated protein 7transporter
DB00694DaunorubicinATP-binding cassette sub-family G member 2transporter
DB00694DaunorubicinDNA topoisomerase 2-alphatarget
DB00694DaunorubicinDNA topoisomerase 2-betatarget
DB00694DaunorubicinCytochrome P450 1A1enzyme
DB00694DaunorubicinCytochrome P450 1A2enzyme
DB00694DaunorubicinCytochrome P450 1B1enzyme
DB00694DaunorubicinCytochrome P450 3A4enzyme
DB00563MethotrexateDihydrofolate reductasetarget
DB00563MethotrexateAldehyde oxidaseenzyme
DB00563MethotrexateMethylenetetrahydrofolate reductaseenzyme
DB00563MethotrexateSerum albumincarrier
DB00563MethotrexateCanalicular multispecific organic anion transporter 2transporter
DB00563MethotrexateMultidrug resistance-associated protein 4transporter
DB00563MethotrexateMultidrug resistance-associated protein 1transporter
DB00563MethotrexateSolute carrier family 22 member 6transporter
DB00563MethotrexateMultidrug resistance-associated protein 7transporter
DB00563MethotrexateSolute carrier family 22 member 8transporter
DB00563MethotrexateCanalicular multispecific organic anion transporter 1transporter
DB00563MethotrexateMultidrug resistance protein 1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1A2transporter
DB00563MethotrexateMonocarboxylate transporter 1transporter
DB00563MethotrexateATP-binding cassette sub-family C member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B3transporter
DB00563MethotrexateSolute carrier family 22 member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1C1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 3A1transporter
DB00563MethotrexateATP-binding cassette sub-family G member 2transporter
DB00563MethotrexateSolute carrier family 22 member 7transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B1transporter
DB00563Methotrexate6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00563MethotrexateProton-coupled folate transportertransporter
DB00563MethotrexateFolylpolyglutamate synthase, mitochondrialenzyme
DB00563MethotrexateGamma-glutamyl hydrolaseenzyme
DB00563MethotrexateDihydrofolate reductaseenzyme
DB00563MethotrexateThymidylate synthaseenzyme
DB00563MethotrexateBifunctional purine biosynthesis protein PURHenzyme
DB00563MethotrexateSolute carrier organic anion transporter family member 4C1transporter
DB00563MethotrexateFolate transporter 1transporter
DB00563MethotrexateFolate receptor alphatransporter
DB01204MitoxantroneDNA topoisomerase 2-alphatarget
DB01204MitoxantroneCytochrome P450 2E1enzyme
DB01204MitoxantroneMultidrug resistance protein 1transporter
DB01204MitoxantroneMultidrug resistance-associated protein 1transporter
DB01204MitoxantroneATP-binding cassette sub-family G member 2transporter
DB01204MitoxantroneDNAtarget
DB01204MitoxantroneCytochrome P450 1B1enzyme
DB01204MitoxantroneCytochrome P450 3A4enzyme
DrugDrug NamePhaseStatusCount
DB125159-aminocamptothecin1Completed1
DB09312Antilymphocyte immunoglobulin (horse)1Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)1Recruiting1
DB00928Azacitidine1Completed1
DB11851Bafetinib1Completed1
DB05015Belinostat1Completed1
DB00188Bortezomib1Completed1
DB12004Briciclib1Terminated1
DB01008Busulfan1Recruiting1
DB01188Ciclopirox1Completed1
DB04815Clioquinol1Terminated1
DB00631Clofarabine1Active Not Recruiting1
DB00631Clofarabine1Unknown Status1
DB00531Cyclophosphamide1Recruiting2
DB00531Cyclophosphamide1Unknown Status1
DB00987Cytarabine1Not Yet Recruiting1
DB00694Daunorubicin1Recruiting1
DB01262Decitabine1Completed1
DB01609Deferasirox1Not Yet Recruiting1
DB01234Dexamethasone1Recruiting1
DB12121Entospletinib1Recruiting1
DB01073Fludarabine1Completed1
DB01073Fludarabine1Recruiting3
DB06186Ipilimumab1Active Not Recruiting1
DB01042Melphalan1Completed1
DB00563Methotrexate1Recruiting1
DB12920Pinometostat1Completed1
DB12146Rigosertib1Completed1
DB00864Tacrolimus1Recruiting1
DB12226Terameprocol1Terminated1
DB04572Thiotepa1Completed1
DB13881Tisagenlecleucel1Completed1
DB00541Vincristine1Completed2
DB00541Vincristine1Recruiting1
DB00541Vincristine1Terminated1
DB04974AP19031 / 2Recruiting1
DB00928Azacitidine1 / 2Active Not Recruiting1
DB01008Busulfan1 / 2Active Not Recruiting1
DB00493Cefotaxime1 / 2Active Not Recruiting1
DB09110Coenzyme M1 / 2Completed1
DB09110Coenzyme M1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Active Not Recruiting1
DB00531Cyclophosphamide1 / 2Completed1
DB00531Cyclophosphamide1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Withdrawn1
DB00987Cytarabine1 / 2Completed1
DB01234Dexamethasone1 / 2Completed1
DB00997Doxorubicin1 / 2Completed1
DB01590Everolimus1 / 2Completed1
DB00099Filgrastim1 / 2Active Not Recruiting1
DB00099Filgrastim1 / 2Completed1
DB01073Fludarabine1 / 2Active Not Recruiting1
DB01073Fludarabine1 / 2Recruiting1
DB01073Fludarabine1 / 2Withdrawn1
DB05889Inotuzumab ozogamicin1 / 2Active Not Recruiting1
DB01042Melphalan1 / 2Active Not Recruiting1
DB00563Methotrexate1 / 2Completed1
DB00959Methylprednisolone1 / 2Completed1
DB12952Methylprednisone1 / 2Completed1
DB06809Plerixafor1 / 2Active Not Recruiting1
DB12146Rigosertib1 / 2Completed1
DB00541Vincristine1 / 2Completed1
DB00437Allopurinol2Recruiting1
DB08878Aminopterin2Completed1
DB00098Antithymocyte immunoglobulin (rabbit)2Unknown Status1
DB00023Asparaginase2Completed1
DB00023Asparaginase2Terminated1
DB01076Atorvastatin2Active Not Recruiting1
DB00928Azacitidine2Active Not Recruiting1
DB00074Basiliximab2Completed1
DB09052Blinatumomab2Recruiting1
DB00188Bortezomib2Terminated1
DB00188Bortezomib2Withdrawn1
DB08870Brentuximab vedotin2Completed1
DB01008Busulfan2Active Not Recruiting2
DB01008Busulfan2Recruiting2
DB01008Busulfan2Terminated1
DB00262Carmustine2Terminated1
DB00493Cefotaxime2Recruiting1
DB00631Clofarabine2Completed1
DB00631Clofarabine2Terminated1
DB09110Coenzyme M2Recruiting1
DB00531Cyclophosphamide2Active Not Recruiting2
DB00531Cyclophosphamide2Completed3
DB00531Cyclophosphamide2Recruiting7
DB00091Cyclosporine2Completed1
DB00091Cyclosporine2Recruiting1
DB00987Cytarabine2Completed1
DB00987Cytarabine2Recruiting1
DB00987Cytarabine2Terminated2
DB01254Dasatinib2Recruiting1
DB00694Daunorubicin2Completed1
DB00694Daunorubicin2Recruiting1
DB01234Dexamethasone2Completed1
DB01234Dexamethasone2Terminated1
DB00997Doxorubicin2Terminated1
DB00773Etoposide2Recruiting1
DB00773Etoposide2Terminated1
DB00099Filgrastim2Active Not Recruiting1
DB00099Filgrastim2Recruiting3
DB01073Fludarabine2Active Not Recruiting2
DB01073Fludarabine2Completed1
DB01073Fludarabine2Recruiting4
DB01073Fludarabine2Terminated1
DB01073Fludarabine2Unknown Status1
DB00741Hydrocortisone2Completed1
DB00741Hydrocortisone2Recruiting1
DB00741Hydrocortisone2Terminated1
DB00619Imatinib2Unknown Status1
DB05889Inotuzumab ozogamicin2Not Yet Recruiting1
DB00650Leucovorin2Completed1
DB00650Leucovorin2Recruiting1
DB00007Leuprolide2Active Not Recruiting1
DB01042Melphalan2Completed1
DB01042Melphalan2Recruiting1
DB01042Melphalan2Terminated1
DB01042Melphalan2Unknown Status1
DB01033Mercaptopurine2Completed1
DB01033Mercaptopurine2Terminated1
DB00563Methotrexate2Active Not Recruiting3
DB00563Methotrexate2Completed1
DB00563Methotrexate2Recruiting1
DB00563Methotrexate2Terminated1
DB01204Mitoxantrone2Terminated1
DB00075Muromonab2Completed1
DB00688Mycophenolate mofetil2Active Not Recruiting1
DB00688Mycophenolate mofetil2Completed2
DB00688Mycophenolate mofetil2Recruiting5
DB00688Mycophenolate mofetil2Unknown Status1
DB00059Pegaspargase2Recruiting1
DB00059Pegaspargase2Terminated1
DB00552Pentostatin2Completed1
DB06809Plerixafor2Recruiting1
DB00635Prednisone2Recruiting1
DB00073Rituximab2Recruiting1
DB08877Ruxolitinib2Completed1
DB00020Sargramostim2Completed1
DB00020Sargramostim2Recruiting1
DB01261Sitagliptin2Active Not Recruiting1
DB00864Tacrolimus2Active Not Recruiting4
DB00864Tacrolimus2Completed1
DB00864Tacrolimus2Recruiting3
DB00864Tacrolimus2Unknown Status1
DB04572Thiotepa2Completed1
DB04572Thiotepa2Recruiting1
DB00352Tioguanine2Completed1
DB00541Vincristine2Completed1
DB00541Vincristine2Recruiting1
DB02546Vorinostat2Terminated1
DB01008Busulfan2 / 3Recruiting1
DB00531Cyclophosphamide2 / 3Recruiting1
DB01076Atorvastatin3Recruiting1
DB00531Cyclophosphamide3Completed1
DB00531Cyclophosphamide3Terminated1
DB00091Cyclosporine3Completed1
DB01073Fludarabine3Completed1
DB08898Glucarpidase3Completed1
DB00563Methotrexate3Recruiting1
DB00563Methotrexate3Terminated1
DB00688Mycophenolate mofetil3Completed1
DB00864Tacrolimus3Recruiting1
DB00020Sargramostim4Not Yet Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)Not AvailableCompleted1
DB00023AsparaginaseNot AvailableNo Longer Available1
DB00074BasiliximabNot AvailableTerminated1
DB01008BusulfanNot AvailableCompleted1
DB00531CyclophosphamideNot AvailableRecruiting1
DB00531CyclophosphamideNot AvailableTerminated1
DB00091CyclosporineNot AvailableRecruiting1
DB00091CyclosporineNot AvailableTerminated1
DB01073FludarabineNot AvailableCompleted1
DB01073FludarabineNot AvailableRecruiting1
DB01073FludarabineNot AvailableTerminated1
DB01042MelphalanNot AvailableCompleted1
DB00688Mycophenolate mofetilNot AvailableRecruiting1
DB00688Mycophenolate mofetilNot AvailableTerminated1
DB10415RabbitNot AvailableCompleted1