- Psychotropic Drugs
- Accession Number
A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents).
Drug Drug Description Tryptophan An amino acid commonly found as a component of total parenteral nutrition. Fluvoxamine A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. Lorazepam A long-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. Reserpine For the treatment of hypertension Citalopram A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression. Pregabalin An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. Temazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia. Reboxetine For the treatment of clinical depression. Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Venlafaxine A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression. Valproic acid An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. Amitriptyline A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Protriptyline A tricyclic antidepressant that is indicated in the treatment of depression only under close clinical supervision. Clozapine An antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Mirtazapine A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. Meprobamate An anxiolytic drug used for the short-term management of anxiety symptoms. Sulpiride Sulpiride is indicated for the treatment of schizophrenia. Alprazolam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. Loxapine A antipsychotic used for the treatment of schizophrenia. Remoxipride Remoxipride is an atypical antipsychotic once used for the treatment of schizophrenia. Promazine A phenothiazine used to manage schizophrenia. Prochlorperazine A phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Dronabinol A synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Chlordiazepoxide A benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period. Duloxetine A serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Nabilone A synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. Haloperidol An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting. Nortriptyline A tricyclic antidepressant used in the treatment of depression. Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Adinazolam For the treatment of anxiety and status epilepticus. Carbamazepine An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia. Fluphenazine A phenothiazine used to treat patients requiring long-term neuroleptic therapy. Clorazepic acid A benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Midazolam A short-acting injectable benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. Flurazepam A long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia. Paroxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. Trimipramine A tricyclic antidepressant used to treat depression. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Tranylcypromine A monoamine oxidase inhibitor used to treat major depressive disorder. Phenelzine A monoamine oxidase inhibitor used to treat atypical, nonendogenous, or neurotic depression. Halazepam Used to relieve anxiety, nervousness, and tension associated with anxiety disorders. Minaprine For the treatment of depression Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Trifluoperazine A phenothiazine used to treat depression, anxiety, and agitation. Progabide Indicated for the treatment of epilepsy. Oxazepam An intermediate-acting benzodiazepine with slow onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawals, and insomnia. Perphenazine A phenothiazine used to treat schizophrenia as well as nausea and vomiting. Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Triazolam A benzodiazepine used for short term treatment of insomnia. Ondansetron A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. Mesoridazine A phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses. Maprotiline A tetracyclic antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression. Gabapentin An anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Pimozide An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. Sertraline A selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. Sibutramine A norepinephrine, serotonin and dopamine reuptake inhibitor indicated to assist with weight loss in obesity. Doxepin A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. Nefazodone An antidepressant used in the treatment of depression. Desipramine A tricyclic antidepressant used in the treatment of depression. Bupropion A norepinephrine and dopamine reuptake inhibitor used in the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid to smoking cessation. Moclobemide A monoamine oxidase inhibitor used in the treatment of major depressive disorder and bipolar disorder. Escitalopram A selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). Chlormezanone Used in the management of anxiety and in the treatment of muscle spasm. Estazolam A benzodiazepine used for the short-term management of insomnia. Quetiapine A psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Chlorprothixene For treatment of psychotic disorders (e.g. schizophrenia) and of acute mania occuring as part of bipolar disorders. Clomipramine A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. Isocarboxazid A monoamine oxidase inhibitor used to treat enduring and debilitating symptoms of depression following inadequate clinical response to other antidepressant drugs. Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Lithium cation Lithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Bufotenine A hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a... Midomafetamine Clinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used... Fencamfamin For the the treatment of depressive fatigue in convalescence and other debilitated states as well as in the treatment of depressive day-time fatigue, lack of concentration and lethargy. 4-Methoxyamphetamine Not Available 4-Bromo-2,5-dimethoxyamphetamine Not Available Dimethyltryptamine Some people use this compound as a psychedelic inducing agent. Tenamfetamine An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons... Flunitrazepam For short-term treatment of severe insomnias, that are not responsive to other hypnotics. Ethyl loflazepate Not Available Bromazepam A short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety. Cathinone Cathinone is a monoamine alkaloid found in the shrub Catha edulis (Khat). Closely related to ephedrine, cathine and other amphetamines, it is probably the main contributor to the stimulant effect... Fludiazepam Used for the short-term treatment of anxiety disorders. Ketazolam A long-acting benzodiazepine used to manage anxiety and insomnia. Prazepam For the treatment of anxiety disorders. Nitrazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures. Acepromazine Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and... Aceprometazine Aceprometazine is often used in combination with meprobamate for the treatment of sleep disorders. Molindone An antipsychotic used to treat schizophrenia. Thiothixene An antipsychotic indicated for the management of schizophrenia. Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. Rolipram A phosphodiesterase inhibitor with antidepressant properties. 7-Nitroindazole Not Available Oxitriptan For use as an antidepressant, appetite suppressant, and sleep aid. Phencyclidine A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to ketamine in structure and in many of its effects. Like... Phenethylamine Not Available Aniracetam Compound with anti-depressive properties used as a mental performance enhancer. Iproniazid For the treatment of depression (originally intended to treat tuberculosis). Nialamide Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine. Lysergic acid diethylamide Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by... Amineptine For the treatment of depression. Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. Osanetant Potential therapy for schizophrenia, depression and visceral pain. Milnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of fibromyalgia and a short-term treatment of major depressive disorder. Sertindole Used in the treatment of schizophrenia. Mianserin For the treatment of depression. Pizotifen A serotonin and tryptamine antagonist indicated for migraine prophylaxis. Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Amisulpride Investigated for use/treatment in schizophrenia and schizoaffective disorders, mania in bipolar disorder, and depression. Deramciclane Investigated for use/treatment in anxiety disorders. Adipiplon Investigated for use/treatment in insomnia and sleep disorders. Dextofisopam Investigated for use/treatment in irritable bowel syndrome (IBS). Esmirtazapine Investigated for use/treatment in insomnia and sleep disorders. Vilazodone An antidepressant agent used for the treatment of major depressive disorder that targets the 5-HT transporter and 5-HT1A receptors. Desvenlafaxine An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults. Tofisopam For the treatment of anxiety and alcohol withdrawal. Lurasidone An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Levomilnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD). Perospirone For the treatment of schizophrenia and acute cases of bipolar mania. Amperozide Amperozide is a diphenylbutylpiperazine atypical antipsychotic which antagonizes 5-HT2A receptors. It inhibits dopamine release and alters the firing of dopaminergic neurons. Investigations regarding the use of the agent revolved primarily... Indalpine Indalpine was one of the first selective serotonin reuptake inhibitors to reach the American market. It was initially marketed by Pharmuka. However, after the emergence of widespread concern regarding adverse... Etifoxine Etifoxine is an anxiolytic and anticonvulsant drug developed by Hoechst in the 1960s. It is used in anxiety disorders and to promote peripheral nerve healing. It does not bind to... Benactyzine Benactyzine is an anticholinergic drug used as an antidepressant in the treatment of depression and associated anxiety. Benactyzine is no longer widely used in medicine, although it is still a... Vortioxetine An atypical antipsychotic and antidepressant indicated for the treatment of major depressive disorder (MDD). Etizolam Indicated for the treatment of generalized anxiety disorder with depression, panic disorder and insomnia. Dosulepin Indicated in the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required. Viloxazine Indicated for the treatment of clinical depression. Melperone For the treatment of schizophrenia, sleep, disorders, agitation and mentally confused states [L1317, L1319, L1322]. Zotepine Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes... Pirlindole For the treatment of major depression. It is being studied in the treatment of fibromyalgia pain syndrome. One study determined that the effect of pirlindole on sensorimotor performance while driving... Toloxatone For the treatment of major depressive disorder. Pipamperone Treatment of chronic psychoses and states of aggressiveness of various origins . Tianeptine Used primarily in the treatment of major depressive disorder and anxiety . It is currently being studied for fibromyalgia pain treatment . Oxaprotiline Investigated for the treatment of depression. Azaperone Azaperone is a pyridinylpiperazine and butyrophenone agent that is capable of eliciting neuroleptic sedative and antiemetic effects. It is subsequently employed predominantly as a veterinary tranquilizer and mainly for pigs... Zolazepam Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It... Psilocybin Psilocybin has been investigated for the treatment of Anxiety and Stage IV Melanoma. In November, 2019, it was granted Breakthrough Therapy status by the FDA. Tetrahydropalmatine Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity). Gepirone Gepirone has been used in trials studying the treatment of Cocaine-Related Disorders. Ecopipam Ecopipam has been used in trials studying the treatment of Tourette's Syndrome, Lesch-Nyhan Disease, Pathological Gambling, and Self-injurious Behavior. Bromperidol Bromperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others. Raclopride Raclopride has been used in trials studying Parkinson Disease. Ritanserin Ritanserin has been used in trials studying the treatment of Cocaine-Related Disorders. Perazine Perazine has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others. Tandospirone Tandospirone has been used in trials studying the treatment of Schizophrenia. Benperidol Benperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others. Opipramol Opipramol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders. Hypericin Hypericin is under investigation for the treatment of Cutaneous T-cell Lymphoma. Tiapride Tiapride is indicated for the treatment of a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitation and aggression in the elderly. Nefiracetam Nefiracetam has been used in trials studying the treatment of Alzheimer's Disease. Dibenzepin Dibenzepin is approved for use in Europe. Alaproclate Alaproclate was developed as one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants by Astra AB (now AstraZeneca) in the 1970s. Development was discontinued due to concerns over hepatotoxicity... Clothiapine Clothiapine has been approved in European countries and is an atypical antipsychotic, shown to be useful in some treatment-resistant patients. Sultopride Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics . Deanol Deanol is commonly referred to as 2-(dimethylamino)ethanol, dimethylaminoethanol (DMAE) or dimethylethanolamine (DMEA). It holds tertiary amine and primary alcohol groups as functional groups. Deanol has been used in the treatment... Lofepramine Not Annotated Medazepam Not Annotated Phenibut Not Annotated Iprindole Not Annotated Mebicar Not Annotated Veralipride Not Annotated Bifemelane Not Annotated Trifluperidol Not Annotated Oxiracetam Not Annotated Loprazolam Loprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent... Fluanisone Not Annotated Dixyrazine Not Annotated Penfluridol Not Annotated Clopenthixol Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Nordazepam An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam. Aripiprazole lauroxil An antipsychotic used to treat schizophrenia in adults. Lithium carbonate A medication used to treat manic episodes of bipolar disorder. Clorgiline An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE. Clobazam A benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome. Lamotrigine A phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder. Selegiline A monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's. Iloperidone An atypical antipsychotic agent used for the acute treatment of schizophrenia in adults. Pimavanserin A second generation atypical antipsychotic used for the treatment of hallucinations and delusions caused by Parkinson's Disease. Cariprazine An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder. Butriptyline Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline. Brilaroxazine Investigated for the treatment of schizophrenia and schizoaffective disorder. Esketamine A NMDA receptor antagonist used for treatment-resistant depression. Salvinorin A Salvinorin A has been investigated for the basic science of Pharmaceutical Preparations. Pinazepam Not Annotated Lithium citrate f Harmine Not Available
- Drugs & Drug Targets