This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Enclomiphene
Accession Number
DB06735
Type
Small Molecule
Groups
Investigational
Description
Not Available
Structure
Thumb
Synonyms
  • Enclomifeno
  • Enclomifenum
  • trans-Clomifene
  • trans-Clomiphene
External IDs
RMI 16,289 / RMI-16,289 / RMI-16289
Product Ingredients
IngredientUNIICASInChI Key
Enclomiphene citrateJ303A6U9Y67599-79-3PYTMYKVIJXPNBD-BTKVJIOYSA-N
International/Other Brands
Androxal
Categories
UNII
R6D2UI4FLS
CAS number
15690-57-0
Weight
Average: 405.97
Monoisotopic: 405.1859422
Chemical Formula
C26H28ClNO
InChI Key
GKIRPKYJQBWNGO-OCEACIFDSA-N
InChI
InChI=1S/C26H28ClNO/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18H,3-4,19-20H2,1-2H3/b26-25+
IUPAC Name
(2-{4-[(E)-2-chloro-1,2-diphenylethenyl]phenoxy}ethyl)diethylamine
SMILES
CCN(CC)CCOC1=CC=C(C=C1)C(=C(\Cl)C1=CC=CC=C1)\C1=CC=CC=C1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AbirateroneThe serum concentration of Enclomiphene can be increased when it is combined with Abiraterone.
ArtemetherThe metabolism of Enclomiphene can be decreased when combined with Artemether.
CelecoxibThe metabolism of Enclomiphene can be decreased when combined with Celecoxib.
ChloroquineThe metabolism of Enclomiphene can be decreased when combined with Chloroquine.
CinacalcetThe metabolism of Enclomiphene can be decreased when combined with Cinacalcet.
ClomipramineThe metabolism of Enclomiphene can be decreased when combined with Clomipramine.
ClozapineThe metabolism of Enclomiphene can be decreased when combined with Clozapine.
CobicistatThe serum concentration of Enclomiphene can be increased when it is combined with Cobicistat.
CocaineThe metabolism of Enclomiphene can be decreased when combined with Cocaine.
CurcuminThe metabolism of Enclomiphene can be decreased when combined with Curcumin.
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
1548953
PubChem Substance
347827784
ChemSpider
1265967
BindingDB
55354
ChEMBL
CHEMBL954
PharmGKB
PA449046
Wikipedia
Enclomifene

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableHealthy Volunteers1
1CompletedDiagnosticSecondary Hypogonadotrophic hypogonadism2
1CompletedTreatmentDrug-Drug Interaction (DDI)1
1CompletedTreatmentNormal Volunteers1
1CompletedTreatmentPharmacokinetics1
1CompletedTreatmentPharmacokinetics / Tolerability1
1CompletedTreatmentSecondary Hypogonadotrophic hypogonadism1
2CompletedTreatmentHypogonadism / Low Testosterone1
2CompletedTreatmentSecondary Hypogonadotrophic hypogonadism / Type 2 Diabetes Mellitus1
2CompletedTreatmentSecondary Hypogonadotrophic hypogonadism2
2, 3WithdrawnTreatmentInfertilities1
3CompletedNot AvailableEffect of Treatment on Bone Mineral Density1
3CompletedTreatmentSecondary Hypogonadotrophic hypogonadism7

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000414 mg/mLALOGPS
logP6.08ALOGPS
logP6.47ChemAxon
logS-6ALOGPS
pKa (Strongest Basic)9.31ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area12.47 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity133.76 m3·mol-1ChemAxon
Polarizability46.93 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0udi-3791200000-10b7e9d8e7060a9b1b01

Taxonomy

Description
This compound belongs to the class of organic compounds known as stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids.
Kingdom
Organic compounds
Super Class
Phenylpropanoids and polyketides
Class
Stilbenes
Sub Class
Not Available
Direct Parent
Stilbenes
Alternative Parents
Diphenylmethanes / Phenoxy compounds / Phenol ethers / Alkyl aryl ethers / Trialkylamines / Vinyl chlorides / Chloroalkenes / Organopnictogen compounds / Organochlorides / Hydrocarbon derivatives
Substituents
Stilbene / Diphenylmethane / Phenoxy compound / Phenol ether / Alkyl aryl ether / Monocyclic benzene moiety / Benzenoid / Tertiary amine / Tertiary aliphatic amine / Ether
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Ghobadi C, Gregory A, Crewe HK, Rostami-Hodjegan A, Lennard MS: CYP2D6 is primarily responsible for the metabolism of clomiphene. Drug Metab Pharmacokinet. 2008;23(2):101-5. [PubMed:18445989]

Drug created on August 30, 2010 13:38 / Updated on August 02, 2018 05:39