This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Pinacidil
Accession Number
DB06762
Type
Small Molecule
Groups
Approved
Description

Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles. It reduces blood pressure and peripheral resistance and produces fluid retention.

Structure
Thumb
Synonyms
  • Pinacidil anhydrous
External IDs
P-1134 / S-1230
Product Ingredients
IngredientUNIICASInChI Key
Pinacidil monohydrate7B0ZZH8P2W85371-64-8AFJCNBBHEVLGCZ-UHFFFAOYSA-N
International/Other Brands
Pindac (Leo Pharm)
Categories
UNII
BB4UGO5K0D
CAS number
60560-33-0
Weight
Average: 245.33
Monoisotopic: 245.164045632
Chemical Formula
C13H19N5
InChI Key
IVVNZDGDKPTYHK-UHFFFAOYSA-N
InChI
InChI=1S/C13H19N5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10H,1-4H3,(H2,15,16,17,18)
IUPAC Name
(E)-N''-cyano-N'-(3,3-dimethylbutan-2-yl)-N-(pyridin-4-yl)guanidine
SMILES
CC(N\C(NC1=CC=NC=C1)=N/C#N)C(C)(C)C

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypotensive activities of Pinacidil.Experimental
AcebutololPinacidil may increase the hypotensive activities of Acebutolol.Approved, Investigational
AcemetacinThe therapeutic efficacy of Pinacidil can be decreased when used in combination with Acemetacin.Approved, Experimental, Investigational
AlfuzosinAlfuzosin may increase the hypotensive activities of Pinacidil.Approved, Investigational
AliskirenPinacidil may increase the hypotensive activities of Aliskiren.Approved, Investigational
AlprenololPinacidil may increase the hypotensive activities of Alprenolol.Approved, Withdrawn
AmbrisentanPinacidil may increase the hypotensive activities of Ambrisentan.Approved, Investigational
AmifostinePinacidil may increase the hypotensive activities of Amifostine.Approved, Investigational
AmiodaroneThe metabolism of Pinacidil can be decreased when combined with Amiodarone.Approved, Investigational
AmlodipinePinacidil may increase the hypotensive activities of Amlodipine.Approved
AmphetamineAmphetamine may increase the hypotensive activities of Pinacidil.Approved, Illicit, Investigational
ApalutamideThe serum concentration of Pinacidil can be decreased when it is combined with Apalutamide.Approved, Investigational
AprepitantThe serum concentration of Pinacidil can be increased when it is combined with Aprepitant.Approved, Investigational
AtazanavirThe metabolism of Pinacidil can be decreased when combined with Atazanavir.Approved, Investigational
AtenololPinacidil may increase the hypotensive activities of Atenolol.Approved
AtomoxetineThe metabolism of Pinacidil can be decreased when combined with Atomoxetine.Approved
AvanafilAvanafil may increase the antihypertensive activities of Pinacidil.Approved
BarnidipinePinacidil may increase the antihypertensive activities of Barnidipine.Approved
BenazeprilPinacidil may increase the hypotensive activities of Benazepril.Approved, Investigational
BendroflumethiazidePinacidil may increase the hypotensive activities of Bendroflumethiazide.Approved
BenmoxinBenmoxin may increase the hypotensive activities of Pinacidil.Withdrawn
BepridilPinacidil may increase the hypotensive activities of Bepridil.Approved, Withdrawn
BetaxololPinacidil may increase the hypotensive activities of Betaxolol.Approved, Investigational
BethanidineBethanidine may increase the hypotensive activities of Pinacidil.Approved
BietaserpinePinacidil may increase the hypotensive activities of Bietaserpine.Experimental
BimatoprostPinacidil may increase the hypotensive activities of Bimatoprost.Approved, Investigational
BisoprololPinacidil may increase the hypotensive activities of Bisoprolol.Approved
BoceprevirThe metabolism of Pinacidil can be decreased when combined with Boceprevir.Approved, Withdrawn
BortezomibThe metabolism of Pinacidil can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Pinacidil can be decreased when it is combined with Bosentan.Approved, Investigational
BQ-123Pinacidil may increase the hypotensive activities of BQ-123.Investigational
BretyliumPinacidil may increase the hypotensive activities of Bretylium.Approved
BrimonidineBrimonidine may increase the antihypertensive activities of Pinacidil.Approved
BrofaromineBrofaromine may increase the hypotensive activities of Pinacidil.Experimental
BupranololPinacidil may increase the hypotensive activities of Bupranolol.Approved
CadralazinePinacidil may increase the hypotensive activities of Cadralazine.Experimental
CafedrinePinacidil may increase the hypotensive activities of Cafedrine.Investigational
CandesartanPinacidil may increase the hypotensive activities of Candesartan.Experimental
Candesartan cilexetilPinacidil may increase the hypotensive activities of Candesartan cilexetil.Approved
CandoxatrilPinacidil may increase the hypotensive activities of Candoxatril.Experimental
CaptoprilPinacidil may increase the hypotensive activities of Captopril.Approved
CarbamazepineThe metabolism of Pinacidil can be increased when combined with Carbamazepine.Approved, Investigational
CaroxazoneCaroxazone may increase the hypotensive activities of Pinacidil.Withdrawn
CarteololPinacidil may increase the hypotensive activities of Carteolol.Approved
CarvedilolPinacidil may increase the hypotensive activities of Carvedilol.Approved, Investigational
CeliprololPinacidil may increase the hypotensive activities of Celiprolol.Approved, Investigational
CeritinibThe serum concentration of Pinacidil can be increased when it is combined with Ceritinib.Approved
ChlorothiazidePinacidil may increase the hypotensive activities of Chlorothiazide.Approved, Vet Approved
ChlorthalidonePinacidil may increase the hypotensive activities of Chlorthalidone.Approved
CicletaninePinacidil may increase the hypotensive activities of Cicletanine.Investigational
CilazaprilPinacidil may increase the hypotensive activities of Cilazapril.Approved
ClarithromycinThe metabolism of Pinacidil can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Pinacidil can be decreased when combined with Clemastine.Approved, Investigational
ClonidineClonidine may increase the hypotensive activities of Pinacidil.Approved
CloranololPinacidil may increase the hypotensive activities of Cloranolol.Experimental
ClotrimazoleThe metabolism of Pinacidil can be decreased when combined with Clotrimazole.Approved, Vet Approved
CobicistatThe metabolism of Pinacidil can be decreased when combined with Cobicistat.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Pinacidil.Approved, Investigational
CrizotinibThe metabolism of Pinacidil can be decreased when combined with Crizotinib.Approved
CryptenaminePinacidil may increase the hypotensive activities of Cryptenamine.Approved
CyclopenthiazidePinacidil may increase the hypotensive activities of Cyclopenthiazide.Experimental
CyclosporineThe metabolism of Pinacidil can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyclothiazidePinacidil may increase the hypotensive activities of Cyclothiazide.Approved
DabrafenibThe serum concentration of Pinacidil can be decreased when it is combined with Dabrafenib.Approved, Investigational
DarunavirThe metabolism of Pinacidil can be decreased when combined with Darunavir.Approved
DasatinibThe serum concentration of Pinacidil can be increased when it is combined with Dasatinib.Approved, Investigational
DebrisoquinDebrisoquin may increase the hypotensive activities of Pinacidil.Approved, Investigational
DeferasiroxThe serum concentration of Pinacidil can be decreased when it is combined with Deferasirox.Approved, Investigational
DelaprilPinacidil may increase the hypotensive activities of Delapril.Experimental
DelavirdineThe metabolism of Pinacidil can be decreased when combined with Delavirdine.Approved
DeserpidinePinacidil may increase the hypotensive activities of Deserpidine.Approved
DiazoxideDiazoxide may increase the hypotensive activities of Pinacidil.Approved
DiethylnorsperminePinacidil may increase the hypotensive activities of Diethylnorspermine.Investigational
DihydralazinePinacidil may increase the hypotensive activities of Dihydralazine.Approved, Investigational
DihydroergotamineThe metabolism of Pinacidil can be decreased when combined with Dihydroergotamine.Approved, Investigational
DiltiazemThe metabolism of Pinacidil can be decreased when combined with Diltiazem.Approved, Investigational
DorzolamidePinacidil may increase the hypotensive activities of Dorzolamide.Approved
DoxazosinDoxazosin may increase the hypotensive activities of Pinacidil.Approved
DoxycyclineThe metabolism of Pinacidil can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronedaroneThe metabolism of Pinacidil can be decreased when combined with Dronedarone.Approved
EfonidipinePinacidil may increase the hypotensive activities of Efonidipine.Approved, Investigational
EnalaprilPinacidil may increase the hypotensive activities of Enalapril.Approved, Vet Approved
EnalaprilatPinacidil may increase the hypotensive activities of Enalaprilat.Approved
EndralazinePinacidil may increase the hypotensive activities of Endralazine.Experimental
EnzalutamideThe serum concentration of Pinacidil can be decreased when it is combined with Enzalutamide.Approved
EpanololPinacidil may increase the hypotensive activities of Epanolol.Experimental
EpoprostenolPinacidil may increase the hypotensive activities of Epoprostenol.Approved
EprosartanPinacidil may increase the hypotensive activities of Eprosartan.Approved
ErythromycinThe metabolism of Pinacidil can be decreased when combined with Erythromycin.Approved, Investigational, Vet Approved
FelodipinePinacidil may increase the hypotensive activities of Felodipine.Approved, Investigational
FenoldopamPinacidil may increase the hypotensive activities of Fenoldopam.Approved
Ferulic acidPinacidil may increase the hypotensive activities of Ferulic acid.Experimental
FluconazoleThe metabolism of Pinacidil can be decreased when combined with Fluconazole.Approved, Investigational
FluvoxamineThe metabolism of Pinacidil can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Pinacidil can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Pinacidil can be increased when it is combined with Fosaprepitant.Approved
FosinoprilPinacidil may increase the hypotensive activities of Fosinopril.Approved
FosphenytoinThe metabolism of Pinacidil can be increased when combined with Fosphenytoin.Approved, Investigational
FurazolidoneFurazolidone may increase the hypotensive activities of Pinacidil.Approved, Investigational, Vet Approved
Fusidic AcidThe serum concentration of Pinacidil can be increased when it is combined with Fusidic Acid.Approved, Investigational
GuanabenzPinacidil may increase the hypotensive activities of Guanabenz.Approved, Investigational
GuanadrelPinacidil may increase the hypotensive activities of Guanadrel.Approved
GuanazodinePinacidil may increase the hypotensive activities of Guanazodine.Experimental
GuanethidinePinacidil may increase the hypotensive activities of Guanethidine.Approved
GuanfacineGuanfacine may increase the hypotensive activities of Pinacidil.Approved, Investigational
GuanoclorPinacidil may increase the hypotensive activities of Guanoclor.Experimental
GuanoxabenzPinacidil may increase the hypotensive activities of Guanoxabenz.Experimental
GuanoxanPinacidil may increase the hypotensive activities of Guanoxan.Experimental
HarmalineHarmaline may increase the hypotensive activities of Pinacidil.Experimental
HexamethoniumPinacidil may increase the hypotensive activities of Hexamethonium.Experimental
HydracarbazineHydracarbazine may increase the hypotensive activities of Pinacidil.Experimental
HydralazineHydralazine may increase the hypotensive activities of Pinacidil.Approved
HydrochlorothiazidePinacidil may increase the hypotensive activities of Hydrochlorothiazide.Approved, Vet Approved
HydroflumethiazidePinacidil may increase the hypotensive activities of Hydroflumethiazide.Approved, Investigational
IdelalisibThe metabolism of Pinacidil can be decreased when combined with Idelalisib.Approved
IloprostIloprost may increase the hypotensive activities of Pinacidil.Approved, Investigational
ImatinibThe metabolism of Pinacidil can be decreased when combined with Imatinib.Approved
ImidaprilPinacidil may increase the hypotensive activities of Imidapril.Investigational
IndapamidePinacidil may increase the hypotensive activities of Indapamide.Approved
IndenololPinacidil may increase the hypotensive activities of Indenolol.Withdrawn
IndinavirThe metabolism of Pinacidil can be decreased when combined with Indinavir.Approved
IndoraminPinacidil may increase the hypotensive activities of Indoramin.Withdrawn
IproclozideIproclozide may increase the hypotensive activities of Pinacidil.Withdrawn
IproniazidIproniazid may increase the hypotensive activities of Pinacidil.Withdrawn
IrbesartanPinacidil may increase the hypotensive activities of Irbesartan.Approved, Investigational
IsavuconazoniumThe metabolism of Pinacidil can be decreased when combined with Isavuconazonium.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Pinacidil.Approved
IsradipineThe metabolism of Pinacidil can be decreased when combined with Isradipine.Approved, Investigational
ItraconazoleThe metabolism of Pinacidil can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Pinacidil can be increased when it is combined with Ivacaftor.Approved
KetanserinPinacidil may increase the hypotensive activities of Ketanserin.Investigational
KetoconazoleThe metabolism of Pinacidil can be decreased when combined with Ketoconazole.Approved, Investigational
LabetalolPinacidil may increase the hypotensive activities of Labetalol.Approved
LacidipinePinacidil may increase the hypotensive activities of Lacidipine.Approved, Investigational
LatanoprostPinacidil may increase the hypotensive activities of Latanoprost.Approved, Investigational
LercanidipinePinacidil may increase the hypotensive activities of Lercanidipine.Approved, Investigational
LinsidominePinacidil may increase the hypotensive activities of Linsidomine.Experimental
LisinoprilPinacidil may increase the hypotensive activities of Lisinopril.Approved, Investigational
LofexidinePinacidil may increase the hypotensive activities of Lofexidine.Approved, Investigational
LopinavirThe metabolism of Pinacidil can be decreased when combined with Lopinavir.Approved
LorpiprazoleThe serum concentration of Pinacidil can be increased when it is combined with Lorpiprazole.Approved
LosartanPinacidil may increase the hypotensive activities of Losartan.Approved
LovastatinThe metabolism of Pinacidil can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Pinacidil can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Pinacidil can be increased when combined with Lumacaftor.Approved
MacitentanPinacidil may increase the hypotensive activities of Macitentan.Approved
ManidipinePinacidil may increase the hypotensive activities of Manidipine.Approved, Investigational
MebanazineMebanazine may increase the hypotensive activities of Pinacidil.Withdrawn
MecamylamineMecamylamine may increase the hypotensive activities of Pinacidil.Approved, Investigational
MethoserpidinePinacidil may increase the hypotensive activities of Methoserpidine.Experimental
MethyldopaPinacidil may increase the hypotensive activities of Methyldopa.Approved
Methylene blueMethylene blue may increase the hypotensive activities of Pinacidil.Approved, Investigational
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Pinacidil.Approved, Investigational
MetipranololPinacidil may increase the hypotensive activities of Metipranolol.Approved
MetolazonePinacidil may increase the hypotensive activities of Metolazone.Approved
MetoprololPinacidil may increase the hypotensive activities of Metoprolol.Approved, Investigational
MetyrosinePinacidil may increase the hypotensive activities of Metyrosine.Approved
MibefradilPinacidil may increase the hypotensive activities of Mibefradil.Investigational, Withdrawn
MifepristoneThe serum concentration of Pinacidil can be increased when it is combined with Mifepristone.Approved, Investigational
MinaprineMinaprine may increase the hypotensive activities of Pinacidil.Approved
MinoxidilMinoxidil may increase the hypotensive activities of Pinacidil.Approved, Investigational
MirodenafilMirodenafil may increase the antihypertensive activities of Pinacidil.Investigational
MitotaneThe serum concentration of Pinacidil can be decreased when it is combined with Mitotane.Approved
MoclobemideMoclobemide may increase the hypotensive activities of Pinacidil.Approved, Investigational
MoexiprilPinacidil may increase the hypotensive activities of Moexipril.Approved
MolsidomineMolsidomine may increase the hypotensive activities of Pinacidil.Approved, Investigational
MoxonidinePinacidil may increase the hypotensive activities of Moxonidine.Approved, Investigational
MuzoliminePinacidil may increase the hypotensive activities of Muzolimine.Experimental
NadololPinacidil may increase the hypotensive activities of Nadolol.Approved
NaftopidilPinacidil may increase the hypotensive activities of Naftopidil.Investigational
NebivololPinacidil may increase the hypotensive activities of Nebivolol.Approved, Investigational
NefazodoneThe metabolism of Pinacidil can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Pinacidil can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Pinacidil can be increased when it is combined with Netupitant.Approved, Investigational
NevirapineThe metabolism of Pinacidil can be increased when combined with Nevirapine.Approved
NialamideNialamide may increase the hypotensive activities of Pinacidil.Withdrawn
NicardipinePinacidil may increase the hypotensive activities of Nicardipine.Approved, Investigational
NicorandilPinacidil may increase the hypotensive activities of Nicorandil.Approved, Investigational
NiguldipinePinacidil may increase the hypotensive activities of Niguldipine.Experimental
NilotinibThe metabolism of Pinacidil can be decreased when combined with Nilotinib.Approved, Investigational
NilvadipinePinacidil may increase the hypotensive activities of Nilvadipine.Approved, Investigational
NimodipinePinacidil may increase the hypotensive activities of Nimodipine.Approved, Investigational
NisoldipinePinacidil may increase the hypotensive activities of Nisoldipine.Approved
NitrendipinePinacidil may increase the hypotensive activities of Nitrendipine.Approved, Investigational
NitroprussideNitroprusside may increase the hypotensive activities of Pinacidil.Approved, Investigational
ObinutuzumabPinacidil may increase the hypotensive activities of Obinutuzumab.Approved, Investigational
OctamoxinOctamoxin may increase the hypotensive activities of Pinacidil.Withdrawn
OlaparibThe metabolism of Pinacidil can be decreased when combined with Olaparib.Approved
OlmesartanPinacidil may increase the hypotensive activities of Olmesartan.Approved, Investigational
OmapatrilatPinacidil may increase the hypotensive activities of Omapatrilat.Investigational
OsimertinibThe serum concentration of Pinacidil can be increased when it is combined with Osimertinib.Approved
OxprenololPinacidil may increase the hypotensive activities of Oxprenolol.Approved
PalbociclibThe serum concentration of Pinacidil can be increased when it is combined with Palbociclib.Approved, Investigational
PargylinePargyline may increase the hypotensive activities of Pinacidil.Approved
PenbutololPinacidil may increase the hypotensive activities of Penbutolol.Approved, Investigational
PentobarbitalThe metabolism of Pinacidil can be increased when combined with Pentobarbital.Approved, Investigational, Vet Approved
PentoliniumPinacidil may increase the hypotensive activities of Pentolinium.Approved
PentoxifyllinePentoxifylline may increase the hypotensive activities of Pinacidil.Approved, Investigational
PerindoprilPinacidil may increase the hypotensive activities of Perindopril.Approved
PhenelzinePhenelzine may increase the hypotensive activities of Pinacidil.Approved
PheniprazinePheniprazine may increase the hypotensive activities of Pinacidil.Withdrawn
PhenobarbitalThe metabolism of Pinacidil can be increased when combined with Phenobarbital.Approved, Investigational
PhenoxybenzaminePinacidil may increase the hypotensive activities of Phenoxybenzamine.Approved
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Pinacidil.Withdrawn
PhentolaminePinacidil may increase the hypotensive activities of Phentolamine.Approved
PhenytoinThe metabolism of Pinacidil can be increased when combined with Phenytoin.Approved, Vet Approved
PindololPinacidil may increase the hypotensive activities of Pindolol.Approved, Investigational
PirlindolePirlindole may increase the hypotensive activities of Pinacidil.Approved
PivhydrazinePivhydrazine may increase the hypotensive activities of Pinacidil.Withdrawn
Platelet Activating FactorPinacidil may increase the hypotensive activities of Platelet Activating Factor.Experimental
PolythiazidePinacidil may increase the hypotensive activities of Polythiazide.Approved
PosaconazoleThe metabolism of Pinacidil can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PrazosinPrazosin may increase the hypotensive activities of Pinacidil.Approved
PrimidoneThe metabolism of Pinacidil can be increased when combined with Primidone.Approved, Vet Approved
ProcarbazineProcarbazine may increase the hypotensive activities of Pinacidil.Approved, Investigational
PropranololPinacidil may increase the hypotensive activities of Propranolol.Approved, Investigational
QuinaprilPinacidil may increase the hypotensive activities of Quinapril.Approved, Investigational
QuinineQuinine may increase the hypotensive activities of Pinacidil.Approved
RamiprilPinacidil may increase the hypotensive activities of Ramipril.Approved
RanolazineThe metabolism of Pinacidil can be decreased when combined with Ranolazine.Approved, Investigational
RasagilineRasagiline may increase the hypotensive activities of Pinacidil.Approved
RemikirenPinacidil may increase the hypotensive activities of Remikiren.Approved
RescinnaminePinacidil may increase the hypotensive activities of Rescinnamine.Approved
ReserpineReserpine may increase the hypotensive activities of Pinacidil.Approved, Investigational
RifabutinThe metabolism of Pinacidil can be increased when combined with Rifabutin.Approved, Investigational
RifampicinThe metabolism of Pinacidil can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Pinacidil can be increased when combined with Rifapentine.Approved, Investigational
RilmenidinePinacidil may increase the hypotensive activities of Rilmenidine.Approved, Investigational
RiociguatPinacidil may increase the hypotensive activities of Riociguat.Approved
RituximabPinacidil may increase the hypotensive activities of Rituximab.Approved
RucaparibThe metabolism of Pinacidil can be decreased when combined with Rucaparib.Approved, Investigational
SafrazineSafrazine may increase the hypotensive activities of Pinacidil.Withdrawn
SaprisartanPinacidil may increase the hypotensive activities of Saprisartan.Experimental
SaquinavirThe metabolism of Pinacidil can be decreased when combined with Saquinavir.Approved, Investigational
SarilumabThe therapeutic efficacy of Pinacidil can be decreased when used in combination with Sarilumab.Approved, Investigational
SelegilineSelegiline may increase the hypotensive activities of Pinacidil.Approved, Investigational, Vet Approved
SelexipagPinacidil may increase the hypotensive activities of Selexipag.Approved
SildenafilSildenafil may increase the antihypertensive activities of Pinacidil.Approved, Investigational
SiltuximabThe serum concentration of Pinacidil can be decreased when it is combined with Siltuximab.Approved, Investigational
SimeprevirThe serum concentration of Pinacidil can be increased when it is combined with Simeprevir.Approved
SitaxentanPinacidil may increase the hypotensive activities of Sitaxentan.Approved, Investigational, Withdrawn
SpiraprilPinacidil may increase the hypotensive activities of Spirapril.Approved
St. John's WortThe serum concentration of Pinacidil can be decreased when it is combined with St. John's Wort.Approved, Investigational, Nutraceutical
StiripentolThe serum concentration of Pinacidil can be increased when it is combined with Stiripentol.Approved
SulfisoxazoleThe metabolism of Pinacidil can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
TadalafilTadalafil may increase the antihypertensive activities of Pinacidil.Approved, Investigational
TalinololPinacidil may increase the hypotensive activities of Talinolol.Investigational
TelaprevirThe metabolism of Pinacidil can be decreased when combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of Pinacidil can be decreased when combined with Telithromycin.Approved
TelmisartanPinacidil may increase the hypotensive activities of Telmisartan.Approved, Investigational
TemocaprilPinacidil may increase the hypotensive activities of Temocapril.Experimental, Investigational
TerlipressinPinacidil may increase the hypotensive activities of Terlipressin.Approved, Investigational
TetrahydropalmatinePinacidil may increase the hypotensive activities of Tetrahydropalmatine.Investigational
TheodrenalinePinacidil may increase the hypotensive activities of Theodrenaline.Investigational
TibolonePinacidil may increase the hypotensive activities of Tibolone.Approved, Investigational
TiclopidineThe metabolism of Pinacidil can be decreased when combined with Ticlopidine.Approved
TicrynafenPinacidil may increase the hypotensive activities of Ticrynafen.Withdrawn
TimololPinacidil may increase the hypotensive activities of Timolol.Approved
TocilizumabThe serum concentration of Pinacidil can be decreased when it is combined with Tocilizumab.Approved
TolazolinePinacidil may increase the hypotensive activities of Tolazoline.Approved, Vet Approved
TolonidinePinacidil may increase the hypotensive activities of Tolonidine.Experimental
ToloxatoneToloxatone may increase the hypotensive activities of Pinacidil.Approved
TorasemidePinacidil may increase the hypotensive activities of Torasemide.Approved
TrandolaprilPinacidil may increase the hypotensive activities of Trandolapril.Approved
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypotensive activities of Pinacidil.Experimental
TranylcypromineTranylcypromine may increase the hypotensive activities of Pinacidil.Approved, Investigational
TravoprostPinacidil may increase the hypotensive activities of Travoprost.Approved
TreprostinilPinacidil may increase the hypotensive activities of Treprostinil.Approved, Investigational
TrichlormethiazidePinacidil may increase the hypotensive activities of Trichlormethiazide.Approved, Vet Approved
TrimazosinPinacidil may increase the hypotensive activities of Trimazosin.Experimental
TrimethaphanTrimethaphan may increase the hypotensive activities of Pinacidil.Approved, Investigational
UdenafilUdenafil may increase the antihypertensive activities of Pinacidil.Approved, Investigational
UnoprostonePinacidil may increase the hypotensive activities of Unoprostone.Approved, Investigational
UrapidilPinacidil may increase the hypotensive activities of Urapidil.Investigational
ValsartanPinacidil may increase the hypotensive activities of Valsartan.Approved, Investigational
VardenafilVardenafil may increase the antihypertensive activities of Pinacidil.Approved
VemurafenibThe serum concentration of Pinacidil can be decreased when it is combined with Vemurafenib.Approved
VenlafaxineThe metabolism of Pinacidil can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Pinacidil can be decreased when combined with Verapamil.Approved
VincaminePinacidil may increase the hypotensive activities of Vincamine.Experimental
VinpocetinePinacidil may increase the hypotensive activities of Vinpocetine.Investigational
VoriconazoleThe metabolism of Pinacidil can be decreased when combined with Voriconazole.Approved, Investigational
XipamidePinacidil may increase the hypotensive activities of Xipamide.Experimental
XylometazolinePinacidil may increase the hypotensive activities of Xylometazoline.Approved, Investigational
YohimbineYohimbine may decrease the antihypertensive activities of Pinacidil.Approved, Investigational, Vet Approved
ZiprasidoneThe metabolism of Pinacidil can be decreased when combined with Ziprasidone.Approved
ZofenoprilPinacidil may increase the hypotensive activities of Zofenopril.Experimental
Food Interactions
Not Available

References

General References
  1. Hansen PR: [Pinacidil (Pindac). A peripheral vasodilator agent with a new mechanism of action]. Ugeskr Laeger. 1989 Oct 30;151(44):2906-8. [PubMed:2588385]
  2. Ahnfelt-Ronne I: Pinacidil. Preclinical investigations. Drugs. 1988;36 Suppl 7:4-9. [PubMed:3076134]
  3. Koliopoulos K, Papadoyannis DE, Karatzas NB: Pinacidil, a new vasodilator, in the treatment of patients with moderate to severe hypertension. Eur J Clin Pharmacol. 1984;27(3):287-9. [PubMed:6510455]
External Links
ChemSpider
4660
BindingDB
50240750
ChEBI
91706
ChEMBL
CHEMBL1159
Wikipedia
Pinacidil
ATC Codes
C02DG01 — PinacidilC02LX01 — Pinacidil and diuretics

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.126 mg/mLALOGPS
logP2.47ALOGPS
logP2.25ChemAxon
logS-3.3ALOGPS
pKa (Strongest Acidic)14.27ChemAxon
pKa (Strongest Basic)5.61ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area73.1 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity72.81 m3·mol-1ChemAxon
Polarizability27.12 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0002-2790000000-b4614b7b3adabc514ad4
MS/MS Spectrum - , positiveLC-MS/MSsplash10-00dj-5901100000-3131ef3fa766db3846ca

Taxonomy

Description
This compound belongs to the class of organic compounds known as pyridines and derivatives. These are compounds containing a pyridine ring, which is a six-member aromatic heterocycle which consists of one nitrogen atom and five carbon atoms.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Pyridines and derivatives
Sub Class
Not Available
Direct Parent
Pyridines and derivatives
Alternative Parents
Heteroaromatic compounds / Guanidines / Propargyl-type 1,3-dipolar organic compounds / Carboximidamides / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives
Substituents
Pyridine / Heteroaromatic compound / Guanidine / Azacycle / Organic 1,3-dipolar compound / Propargyl-type 1,3-dipolar organic compound / Carboximidamide / Organic nitrogen compound / Organopnictogen compound / Hydrocarbon derivative
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Zhang Z, Li Y, Stearns RA, Ortiz De Montellano PR, Baillie TA, Tang W: Cytochrome P450 3A4-mediated oxidative conversion of a cyano to an amide group in the metabolism of pinacidil. Biochemistry. 2002 Feb 26;41(8):2712-8. [PubMed:11851418]

Drug created on September 14, 2010 10:21 / Updated on February 06, 2018 19:24