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IdentificationPharmacologyInteractionsReferencesTrialsEconomicsPropertiesSpectraTaxonomyPinacidil
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Name
- Pinacidil
- Accession Number
- DB06762
- Type
- Small Molecule
- Groups
- Approved
- Description
Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles. It reduces blood pressure and peripheral resistance and produces fluid retention.
- Structure
Structure for DB06762 (Pinacidil)
- Synonyms
- Pinacidil anhydrous
- External IDs
- P-1134 / S-1230
- Product Ingredients
Ingredient UNII CAS InChI Key Pinacidil monohydrate 7B0ZZH8P2W 85371-64-8 AFJCNBBHEVLGCZ-UHFFFAOYSA-N - International/Other Brands
- Pindac (Leo Pharm)
- Categories
- UNII
- BB4UGO5K0D
- CAS number
- 60560-33-0
- Weight
- Average: 245.33
Monoisotopic: 245.164045632 - Chemical Formula
- C13H19N5
- InChI Key
- IVVNZDGDKPTYHK-UHFFFAOYSA-N
- InChI
- InChI=1S/C13H19N5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10H,1-4H3,(H2,15,16,17,18)
- IUPAC Name
- (E)-N''-cyano-N'-(3,3-dimethylbutan-2-yl)-N-(pyridin-4-yl)guanidine
- SMILES
- CC(N\C(NC1=CC=NC=C1)=N/C#N)C(C)(C)C
Pharmacology
- Indication
- Not Available
- Structured Indications
- Not Available
- Pharmacodynamics
- Not Available
- Mechanism of action
- Not Available
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half life
- Not Available
- Clearance
- Not Available
- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
Drug Interaction Drug group 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypotensive activities of Pinacidil. Experimental Acebutolol Pinacidil may increase the hypotensive activities of Acebutolol. Approved, Investigational Acemetacin The therapeutic efficacy of Pinacidil can be decreased when used in combination with Acemetacin. Approved, Experimental, Investigational Alfuzosin Alfuzosin may increase the hypotensive activities of Pinacidil. Approved, Investigational Aliskiren Pinacidil may increase the hypotensive activities of Aliskiren. Approved, Investigational Alprenolol Pinacidil may increase the hypotensive activities of Alprenolol. Approved, Withdrawn Ambrisentan Pinacidil may increase the hypotensive activities of Ambrisentan. Approved, Investigational Amifostine Pinacidil may increase the hypotensive activities of Amifostine. Approved, Investigational Amiodarone The metabolism of Pinacidil can be decreased when combined with Amiodarone. Approved, Investigational Amlodipine Pinacidil may increase the hypotensive activities of Amlodipine. Approved Amphetamine Amphetamine may increase the hypotensive activities of Pinacidil. Approved, Illicit, Investigational Apalutamide The serum concentration of Pinacidil can be decreased when it is combined with Apalutamide. Approved, Investigational Aprepitant The serum concentration of Pinacidil can be increased when it is combined with Aprepitant. Approved, Investigational Atazanavir The metabolism of Pinacidil can be decreased when combined with Atazanavir. Approved, Investigational Atenolol Pinacidil may increase the hypotensive activities of Atenolol. Approved Atomoxetine The metabolism of Pinacidil can be decreased when combined with Atomoxetine. Approved Avanafil Avanafil may increase the antihypertensive activities of Pinacidil. Approved Barnidipine Pinacidil may increase the antihypertensive activities of Barnidipine. Approved Benazepril Pinacidil may increase the hypotensive activities of Benazepril. Approved, Investigational Bendroflumethiazide Pinacidil may increase the hypotensive activities of Bendroflumethiazide. Approved Benmoxin Benmoxin may increase the hypotensive activities of Pinacidil. Withdrawn Bepridil Pinacidil may increase the hypotensive activities of Bepridil. Approved, Withdrawn Betaxolol Pinacidil may increase the hypotensive activities of Betaxolol. Approved, Investigational Bethanidine Bethanidine may increase the hypotensive activities of Pinacidil. Approved Bietaserpine Pinacidil may increase the hypotensive activities of Bietaserpine. Experimental Bimatoprost Pinacidil may increase the hypotensive activities of Bimatoprost. Approved, Investigational Bisoprolol Pinacidil may increase the hypotensive activities of Bisoprolol. Approved Boceprevir The metabolism of Pinacidil can be decreased when combined with Boceprevir. Approved, Withdrawn Bortezomib The metabolism of Pinacidil can be decreased when combined with Bortezomib. Approved, Investigational Bosentan The serum concentration of Pinacidil can be decreased when it is combined with Bosentan. Approved, Investigational BQ-123 Pinacidil may increase the hypotensive activities of BQ-123. Investigational Bretylium Pinacidil may increase the hypotensive activities of Bretylium. Approved Brimonidine Brimonidine may increase the antihypertensive activities of Pinacidil. Approved Brofaromine Brofaromine may increase the hypotensive activities of Pinacidil. Experimental Bupranolol Pinacidil may increase the hypotensive activities of Bupranolol. Approved Cadralazine Pinacidil may increase the hypotensive activities of Cadralazine. Experimental Cafedrine Pinacidil may increase the hypotensive activities of Cafedrine. Investigational Candesartan Pinacidil may increase the hypotensive activities of Candesartan. Experimental Candesartan cilexetil Pinacidil may increase the hypotensive activities of Candesartan cilexetil. Approved Candoxatril Pinacidil may increase the hypotensive activities of Candoxatril. Experimental Captopril Pinacidil may increase the hypotensive activities of Captopril. Approved Carbamazepine The metabolism of Pinacidil can be increased when combined with Carbamazepine. Approved, Investigational Caroxazone Caroxazone may increase the hypotensive activities of Pinacidil. Withdrawn Carteolol Pinacidil may increase the hypotensive activities of Carteolol. Approved Carvedilol Pinacidil may increase the hypotensive activities of Carvedilol. Approved, Investigational Celiprolol Pinacidil may increase the hypotensive activities of Celiprolol. Approved, Investigational Ceritinib The serum concentration of Pinacidil can be increased when it is combined with Ceritinib. Approved Chlorothiazide Pinacidil may increase the hypotensive activities of Chlorothiazide. Approved, Vet Approved Chlorthalidone Pinacidil may increase the hypotensive activities of Chlorthalidone. Approved Cicletanine Pinacidil may increase the hypotensive activities of Cicletanine. Investigational Cilazapril Pinacidil may increase the hypotensive activities of Cilazapril. Approved Clarithromycin The metabolism of Pinacidil can be decreased when combined with Clarithromycin. Approved Clemastine The metabolism of Pinacidil can be decreased when combined with Clemastine. Approved, Investigational Clonidine Clonidine may increase the hypotensive activities of Pinacidil. Approved Cloranolol Pinacidil may increase the hypotensive activities of Cloranolol. Experimental Clotrimazole The metabolism of Pinacidil can be decreased when combined with Clotrimazole. Approved, Vet Approved Cobicistat The metabolism of Pinacidil can be decreased when combined with Cobicistat. Approved Conivaptan The serum concentration of Conivaptan can be increased when it is combined with Pinacidil. Approved, Investigational Crizotinib The metabolism of Pinacidil can be decreased when combined with Crizotinib. Approved Cryptenamine Pinacidil may increase the hypotensive activities of Cryptenamine. Approved Cyclopenthiazide Pinacidil may increase the hypotensive activities of Cyclopenthiazide. Experimental Cyclosporine The metabolism of Pinacidil can be decreased when combined with Cyclosporine. Approved, Investigational, Vet Approved Cyclothiazide Pinacidil may increase the hypotensive activities of Cyclothiazide. Approved Dabrafenib The serum concentration of Pinacidil can be decreased when it is combined with Dabrafenib. Approved, Investigational Darunavir The metabolism of Pinacidil can be decreased when combined with Darunavir. Approved Dasatinib The serum concentration of Pinacidil can be increased when it is combined with Dasatinib. Approved, Investigational Debrisoquin Debrisoquin may increase the hypotensive activities of Pinacidil. Approved, Investigational Deferasirox The serum concentration of Pinacidil can be decreased when it is combined with Deferasirox. Approved, Investigational Delapril Pinacidil may increase the hypotensive activities of Delapril. Experimental Delavirdine The metabolism of Pinacidil can be decreased when combined with Delavirdine. Approved Deserpidine Pinacidil may increase the hypotensive activities of Deserpidine. Approved Diazoxide Diazoxide may increase the hypotensive activities of Pinacidil. Approved Diethylnorspermine Pinacidil may increase the hypotensive activities of Diethylnorspermine. Investigational Dihydralazine Pinacidil may increase the hypotensive activities of Dihydralazine. Approved, Investigational Dihydroergotamine The metabolism of Pinacidil can be decreased when combined with Dihydroergotamine. Approved, Investigational Diltiazem The metabolism of Pinacidil can be decreased when combined with Diltiazem. Approved, Investigational Dorzolamide Pinacidil may increase the hypotensive activities of Dorzolamide. Approved Doxazosin Doxazosin may increase the hypotensive activities of Pinacidil. Approved Doxycycline The metabolism of Pinacidil can be decreased when combined with Doxycycline. Approved, Investigational, Vet Approved Dronedarone The metabolism of Pinacidil can be decreased when combined with Dronedarone. Approved Efonidipine Pinacidil may increase the hypotensive activities of Efonidipine. Approved, Investigational Enalapril Pinacidil may increase the hypotensive activities of Enalapril. Approved, Vet Approved Enalaprilat Pinacidil may increase the hypotensive activities of Enalaprilat. Approved Endralazine Pinacidil may increase the hypotensive activities of Endralazine. Experimental Enzalutamide The serum concentration of Pinacidil can be decreased when it is combined with Enzalutamide. Approved Epanolol Pinacidil may increase the hypotensive activities of Epanolol. Experimental Epoprostenol Pinacidil may increase the hypotensive activities of Epoprostenol. Approved Eprosartan Pinacidil may increase the hypotensive activities of Eprosartan. Approved Erythromycin The metabolism of Pinacidil can be decreased when combined with Erythromycin. Approved, Investigational, Vet Approved Felodipine Pinacidil may increase the hypotensive activities of Felodipine. Approved, Investigational Fenoldopam Pinacidil may increase the hypotensive activities of Fenoldopam. Approved Ferulic acid Pinacidil may increase the hypotensive activities of Ferulic acid. Experimental Fluconazole The metabolism of Pinacidil can be decreased when combined with Fluconazole. Approved, Investigational Fluvoxamine The metabolism of Pinacidil can be decreased when combined with Fluvoxamine. Approved, Investigational Fosamprenavir The metabolism of Pinacidil can be decreased when combined with Fosamprenavir. Approved Fosaprepitant The serum concentration of Pinacidil can be increased when it is combined with Fosaprepitant. Approved Fosinopril Pinacidil may increase the hypotensive activities of Fosinopril. Approved Fosphenytoin The metabolism of Pinacidil can be increased when combined with Fosphenytoin. Approved, Investigational Furazolidone Furazolidone may increase the hypotensive activities of Pinacidil. Approved, Investigational, Vet Approved Fusidic Acid The serum concentration of Pinacidil can be increased when it is combined with Fusidic Acid. Approved, Investigational Guanabenz Pinacidil may increase the hypotensive activities of Guanabenz. Approved, Investigational Guanadrel Pinacidil may increase the hypotensive activities of Guanadrel. Approved Guanazodine Pinacidil may increase the hypotensive activities of Guanazodine. Experimental Guanethidine Pinacidil may increase the hypotensive activities of Guanethidine. Approved Guanfacine Guanfacine may increase the hypotensive activities of Pinacidil. Approved, Investigational Guanoclor Pinacidil may increase the hypotensive activities of Guanoclor. Experimental Guanoxabenz Pinacidil may increase the hypotensive activities of Guanoxabenz. Experimental Guanoxan Pinacidil may increase the hypotensive activities of Guanoxan. Experimental Harmaline Harmaline may increase the hypotensive activities of Pinacidil. Experimental Hexamethonium Pinacidil may increase the hypotensive activities of Hexamethonium. Experimental Hydracarbazine Hydracarbazine may increase the hypotensive activities of Pinacidil. Experimental Hydralazine Hydralazine may increase the hypotensive activities of Pinacidil. Approved Hydrochlorothiazide Pinacidil may increase the hypotensive activities of Hydrochlorothiazide. Approved, Vet Approved Hydroflumethiazide Pinacidil may increase the hypotensive activities of Hydroflumethiazide. Approved, Investigational Idelalisib The metabolism of Pinacidil can be decreased when combined with Idelalisib. Approved Iloprost Iloprost may increase the hypotensive activities of Pinacidil. Approved, Investigational Imatinib The metabolism of Pinacidil can be decreased when combined with Imatinib. Approved Imidapril Pinacidil may increase the hypotensive activities of Imidapril. Investigational Indapamide Pinacidil may increase the hypotensive activities of Indapamide. Approved Indenolol Pinacidil may increase the hypotensive activities of Indenolol. Withdrawn Indinavir The metabolism of Pinacidil can be decreased when combined with Indinavir. Approved Indoramin Pinacidil may increase the hypotensive activities of Indoramin. Withdrawn Iproclozide Iproclozide may increase the hypotensive activities of Pinacidil. Withdrawn Iproniazid Iproniazid may increase the hypotensive activities of Pinacidil. Withdrawn Irbesartan Pinacidil may increase the hypotensive activities of Irbesartan. Approved, Investigational Isavuconazole The serum concentration of Pinacidil can be increased when it is combined with Isavuconazole. Approved, Investigational Isavuconazonium The metabolism of Pinacidil can be decreased when combined with Isavuconazonium. Approved, Investigational Isocarboxazid Isocarboxazid may increase the hypotensive activities of Pinacidil. Approved Isradipine The metabolism of Pinacidil can be decreased when combined with Isradipine. Approved, Investigational Itraconazole The metabolism of Pinacidil can be decreased when combined with Itraconazole. Approved, Investigational Ivacaftor The serum concentration of Pinacidil can be increased when it is combined with Ivacaftor. Approved Ketanserin Pinacidil may increase the hypotensive activities of Ketanserin. Investigational Ketoconazole The metabolism of Pinacidil can be decreased when combined with Ketoconazole. Approved, Investigational Labetalol Pinacidil may increase the hypotensive activities of Labetalol. Approved Lacidipine Pinacidil may increase the hypotensive activities of Lacidipine. Approved, Investigational Latanoprost Pinacidil may increase the hypotensive activities of Latanoprost. Approved, Investigational Lercanidipine Pinacidil may increase the hypotensive activities of Lercanidipine. Approved, Investigational Linsidomine Pinacidil may increase the hypotensive activities of Linsidomine. Experimental Lisinopril Pinacidil may increase the hypotensive activities of Lisinopril. Approved, Investigational Lofexidine Pinacidil may increase the hypotensive activities of Lofexidine. Approved, Investigational Lopinavir The metabolism of Pinacidil can be decreased when combined with Lopinavir. Approved Lorpiprazole The serum concentration of Pinacidil can be increased when it is combined with Lorpiprazole. Approved Losartan Pinacidil may increase the hypotensive activities of Losartan. Approved Lovastatin The metabolism of Pinacidil can be decreased when combined with Lovastatin. Approved, Investigational Luliconazole The serum concentration of Pinacidil can be increased when it is combined with Luliconazole. Approved Lumacaftor The metabolism of Pinacidil can be increased when combined with Lumacaftor. Approved Macitentan Pinacidil may increase the hypotensive activities of Macitentan. Approved Manidipine Pinacidil may increase the hypotensive activities of Manidipine. Approved, Investigational Mebanazine Mebanazine may increase the hypotensive activities of Pinacidil. Withdrawn Mecamylamine Mecamylamine may increase the hypotensive activities of Pinacidil. Approved, Investigational Methoserpidine Pinacidil may increase the hypotensive activities of Methoserpidine. Experimental Methyldopa Pinacidil may increase the hypotensive activities of Methyldopa. Approved Methylene blue Methylene blue may increase the hypotensive activities of Pinacidil. Approved, Investigational Methylphenidate Methylphenidate may decrease the antihypertensive activities of Pinacidil. Approved, Investigational Metipranolol Pinacidil may increase the hypotensive activities of Metipranolol. Approved Metolazone Pinacidil may increase the hypotensive activities of Metolazone. Approved Metoprolol Pinacidil may increase the hypotensive activities of Metoprolol. Approved, Investigational Metyrosine Pinacidil may increase the hypotensive activities of Metyrosine. Approved Mibefradil Pinacidil may increase the hypotensive activities of Mibefradil. Investigational, Withdrawn Mifepristone The serum concentration of Pinacidil can be increased when it is combined with Mifepristone. Approved, Investigational Minaprine Minaprine may increase the hypotensive activities of Pinacidil. Approved Minoxidil Minoxidil may increase the hypotensive activities of Pinacidil. Approved, Investigational Mirodenafil Mirodenafil may increase the antihypertensive activities of Pinacidil. Investigational Mitotane The serum concentration of Pinacidil can be decreased when it is combined with Mitotane. Approved Moclobemide Moclobemide may increase the hypotensive activities of Pinacidil. Approved, Investigational Moexipril Pinacidil may increase the hypotensive activities of Moexipril. Approved Molsidomine Molsidomine may increase the hypotensive activities of Pinacidil. Approved, Investigational Moxonidine Pinacidil may increase the hypotensive activities of Moxonidine. Approved, Investigational Muzolimine Pinacidil may increase the hypotensive activities of Muzolimine. Experimental Nadolol Pinacidil may increase the hypotensive activities of Nadolol. Approved Naftopidil Pinacidil may increase the hypotensive activities of Naftopidil. Investigational Nebivolol Pinacidil may increase the hypotensive activities of Nebivolol. Approved, Investigational Nefazodone The metabolism of Pinacidil can be decreased when combined with Nefazodone. Approved, Withdrawn Nelfinavir The metabolism of Pinacidil can be decreased when combined with Nelfinavir. Approved Netupitant The serum concentration of Pinacidil can be increased when it is combined with Netupitant. Approved, Investigational Nevirapine The metabolism of Pinacidil can be increased when combined with Nevirapine. Approved Nialamide Nialamide may increase the hypotensive activities of Pinacidil. Withdrawn Nicardipine Pinacidil may increase the hypotensive activities of Nicardipine. Approved, Investigational Nicorandil Pinacidil may increase the hypotensive activities of Nicorandil. Approved, Investigational Niguldipine Pinacidil may increase the hypotensive activities of Niguldipine. Experimental Nilotinib The metabolism of Pinacidil can be decreased when combined with Nilotinib. Approved, Investigational Nilvadipine Pinacidil may increase the hypotensive activities of Nilvadipine. Approved, Investigational Nimodipine Pinacidil may increase the hypotensive activities of Nimodipine. Approved, Investigational Nisoldipine Pinacidil may increase the hypotensive activities of Nisoldipine. Approved Nitrendipine Pinacidil may increase the hypotensive activities of Nitrendipine. Approved, Investigational Nitroprusside Nitroprusside may increase the hypotensive activities of Pinacidil. Approved, Investigational Obinutuzumab Pinacidil may increase the hypotensive activities of Obinutuzumab. Approved, Investigational Octamoxin Octamoxin may increase the hypotensive activities of Pinacidil. Withdrawn Olaparib The metabolism of Pinacidil can be decreased when combined with Olaparib. Approved Olmesartan Pinacidil may increase the hypotensive activities of Olmesartan. Approved, Investigational Omapatrilat Pinacidil may increase the hypotensive activities of Omapatrilat. Investigational Osimertinib The serum concentration of Pinacidil can be increased when it is combined with Osimertinib. Approved Oxprenolol Pinacidil may increase the hypotensive activities of Oxprenolol. Approved Palbociclib The serum concentration of Pinacidil can be increased when it is combined with Palbociclib. Approved, Investigational Pargyline Pargyline may increase the hypotensive activities of Pinacidil. Approved Penbutolol Pinacidil may increase the hypotensive activities of Penbutolol. Approved, Investigational Pentobarbital The metabolism of Pinacidil can be increased when combined with Pentobarbital. Approved, Investigational, Vet Approved Pentolinium Pinacidil may increase the hypotensive activities of Pentolinium. Approved Pentoxifylline Pentoxifylline may increase the hypotensive activities of Pinacidil. Approved, Investigational Perindopril Pinacidil may increase the hypotensive activities of Perindopril. Approved Phenelzine Phenelzine may increase the hypotensive activities of Pinacidil. Approved Pheniprazine Pheniprazine may increase the hypotensive activities of Pinacidil. Withdrawn Phenobarbital The metabolism of Pinacidil can be increased when combined with Phenobarbital. Approved, Investigational Phenoxybenzamine Pinacidil may increase the hypotensive activities of Phenoxybenzamine. Approved Phenoxypropazine Phenoxypropazine may increase the hypotensive activities of Pinacidil. Withdrawn Phentolamine Pinacidil may increase the hypotensive activities of Phentolamine. Approved Phenytoin The metabolism of Pinacidil can be increased when combined with Phenytoin. Approved, Vet Approved Pindolol Pinacidil may increase the hypotensive activities of Pindolol. Approved, Investigational Pirlindole Pirlindole may increase the hypotensive activities of Pinacidil. Approved Pitolisant The serum concentration of Pinacidil can be decreased when it is combined with Pitolisant. Approved, Investigational Pivhydrazine Pivhydrazine may increase the hypotensive activities of Pinacidil. Withdrawn Platelet Activating Factor Pinacidil may increase the hypotensive activities of Platelet Activating Factor. Experimental Polythiazide Pinacidil may increase the hypotensive activities of Polythiazide. Approved Posaconazole The metabolism of Pinacidil can be decreased when combined with Posaconazole. Approved, Investigational, Vet Approved Prazosin Prazosin may increase the hypotensive activities of Pinacidil. Approved Primidone The metabolism of Pinacidil can be increased when combined with Primidone. Approved, Vet Approved Procarbazine Procarbazine may increase the hypotensive activities of Pinacidil. Approved, Investigational Propranolol Pinacidil may increase the hypotensive activities of Propranolol. Approved, Investigational Quinapril Pinacidil may increase the hypotensive activities of Quinapril. Approved, Investigational Quinine Quinine may increase the hypotensive activities of Pinacidil. Approved Ramipril Pinacidil may increase the hypotensive activities of Ramipril. Approved Ranolazine The metabolism of Pinacidil can be decreased when combined with Ranolazine. Approved, Investigational Rasagiline Rasagiline may increase the hypotensive activities of Pinacidil. Approved Remikiren Pinacidil may increase the hypotensive activities of Remikiren. Approved Rescinnamine Pinacidil may increase the hypotensive activities of Rescinnamine. Approved Reserpine Reserpine may increase the hypotensive activities of Pinacidil. Approved, Investigational Rifabutin The metabolism of Pinacidil can be increased when combined with Rifabutin. Approved, Investigational Rifampicin The metabolism of Pinacidil can be increased when combined with Rifampicin. Approved Rifapentine The metabolism of Pinacidil can be increased when combined with Rifapentine. Approved, Investigational Rilmenidine Pinacidil may increase the hypotensive activities of Rilmenidine. Approved, Investigational Riociguat Pinacidil may increase the hypotensive activities of Riociguat. Approved Rituximab Pinacidil may increase the hypotensive activities of Rituximab. Approved Rucaparib The metabolism of Pinacidil can be decreased when combined with Rucaparib. Approved, Investigational Safrazine Safrazine may increase the hypotensive activities of Pinacidil. Withdrawn Saprisartan Pinacidil may increase the hypotensive activities of Saprisartan. Experimental Saquinavir The metabolism of Pinacidil can be decreased when combined with Saquinavir. Approved, Investigational Sarilumab The therapeutic efficacy of Pinacidil can be decreased when used in combination with Sarilumab. Approved, Investigational Selegiline Selegiline may increase the hypotensive activities of Pinacidil. Approved, Investigational, Vet Approved Selexipag Pinacidil may increase the hypotensive activities of Selexipag. Approved Sildenafil Sildenafil may increase the antihypertensive activities of Pinacidil. Approved, Investigational Siltuximab The serum concentration of Pinacidil can be decreased when it is combined with Siltuximab. Approved, Investigational Simeprevir The serum concentration of Pinacidil can be increased when it is combined with Simeprevir. Approved Sitaxentan Pinacidil may increase the hypotensive activities of Sitaxentan. Approved, Investigational, Withdrawn Spirapril Pinacidil may increase the hypotensive activities of Spirapril. Approved St. John's Wort The serum concentration of Pinacidil can be decreased when it is combined with St. John's Wort. Approved, Investigational, Nutraceutical Stiripentol The serum concentration of Pinacidil can be increased when it is combined with Stiripentol. Approved Sulfisoxazole The metabolism of Pinacidil can be decreased when combined with Sulfisoxazole. Approved, Vet Approved Tadalafil Tadalafil may increase the antihypertensive activities of Pinacidil. Approved, Investigational Talinolol Pinacidil may increase the hypotensive activities of Talinolol. Investigational Telaprevir The metabolism of Pinacidil can be decreased when combined with Telaprevir. Approved, Withdrawn Telithromycin The metabolism of Pinacidil can be decreased when combined with Telithromycin. Approved Telmisartan Pinacidil may increase the hypotensive activities of Telmisartan. Approved, Investigational Temocapril Pinacidil may increase the hypotensive activities of Temocapril. Experimental, Investigational Terlipressin Pinacidil may increase the hypotensive activities of Terlipressin. Approved, Investigational Tetrahydropalmatine Pinacidil may increase the hypotensive activities of Tetrahydropalmatine. Investigational Theodrenaline Pinacidil may increase the hypotensive activities of Theodrenaline. Investigational Tibolone Pinacidil may increase the hypotensive activities of Tibolone. Approved, Investigational Ticlopidine The metabolism of Pinacidil can be decreased when combined with Ticlopidine. Approved Ticrynafen Pinacidil may increase the hypotensive activities of Ticrynafen. Withdrawn Timolol Pinacidil may increase the hypotensive activities of Timolol. Approved Tocilizumab The serum concentration of Pinacidil can be decreased when it is combined with Tocilizumab. Approved Tolazoline Pinacidil may increase the hypotensive activities of Tolazoline. Approved, Vet Approved Tolonidine Pinacidil may increase the hypotensive activities of Tolonidine. Experimental Toloxatone Toloxatone may increase the hypotensive activities of Pinacidil. Approved Torasemide Pinacidil may increase the hypotensive activities of Torasemide. Approved Trandolapril Pinacidil may increase the hypotensive activities of Trandolapril. Approved Tranylcypromine Tranylcypromine may increase the hypotensive activities of Pinacidil. Approved, Investigational Travoprost Pinacidil may increase the hypotensive activities of Travoprost. Approved Treprostinil Pinacidil may increase the hypotensive activities of Treprostinil. Approved, Investigational Trichlormethiazide Pinacidil may increase the hypotensive activities of Trichlormethiazide. Approved, Vet Approved Trimazosin Pinacidil may increase the hypotensive activities of Trimazosin. Experimental Trimethaphan Trimethaphan may increase the hypotensive activities of Pinacidil. Approved, Investigational Udenafil Udenafil may increase the antihypertensive activities of Pinacidil. Approved, Investigational Unoprostone Pinacidil may increase the hypotensive activities of Unoprostone. Approved, Investigational Urapidil Pinacidil may increase the hypotensive activities of Urapidil. Investigational Valsartan Pinacidil may increase the hypotensive activities of Valsartan. Approved, Investigational Vardenafil Vardenafil may increase the antihypertensive activities of Pinacidil. Approved Vemurafenib The serum concentration of Pinacidil can be decreased when it is combined with Vemurafenib. Approved Venlafaxine The metabolism of Pinacidil can be decreased when combined with Venlafaxine. Approved Verapamil The metabolism of Pinacidil can be decreased when combined with Verapamil. Approved Vincamine Pinacidil may increase the hypotensive activities of Vincamine. Experimental Vinpocetine Pinacidil may increase the hypotensive activities of Vinpocetine. Investigational Voriconazole The metabolism of Pinacidil can be decreased when combined with Voriconazole. Approved, Investigational Xipamide Pinacidil may increase the hypotensive activities of Xipamide. Experimental Xylometazoline Pinacidil may increase the hypotensive activities of Xylometazoline. Approved, Investigational Yohimbine Yohimbine may decrease the antihypertensive activities of Pinacidil. Approved, Investigational, Vet Approved Ziprasidone The metabolism of Pinacidil can be decreased when combined with Ziprasidone. Approved Zofenopril Pinacidil may increase the hypotensive activities of Zofenopril. Experimental - Food Interactions
- Not Available
References
- General References
- Hansen PR: [Pinacidil (Pindac). A peripheral vasodilator agent with a new mechanism of action]. Ugeskr Laeger. 1989 Oct 30;151(44):2906-8. [PubMed:2588385]
- Ahnfelt-Ronne I: Pinacidil. Preclinical investigations. Drugs. 1988;36 Suppl 7:4-9. [PubMed:3076134]
- Koliopoulos K, Papadoyannis DE, Karatzas NB: Pinacidil, a new vasodilator, in the treatment of patients with moderate to severe hypertension. Eur J Clin Pharmacol. 1984;27(3):287-9. [PubMed:6510455]
- External Links
- ChemSpider
- 4660
- BindingDB
- 50240750
- ChEBI
- 91706
- ChEMBL
- CHEMBL1159
- Wikipedia
- Pinacidil
- ATC Codes
- C02DG01 — Pinacidil
- C02DG — Guanidine derivatives
- C02D — ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
- C02 — ANTIHYPERTENSIVES
- C — CARDIOVASCULAR SYSTEM
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.126 mg/mL ALOGPS logP 2.47 ALOGPS logP 2.25 ChemAxon logS -3.3 ALOGPS pKa (Strongest Acidic) 14.27 ChemAxon pKa (Strongest Basic) 5.61 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 5 ChemAxon Hydrogen Donor Count 2 ChemAxon Polar Surface Area 73.1 Å2 ChemAxon Rotatable Bond Count 3 ChemAxon Refractivity 72.81 m3·mol-1 ChemAxon Polarizability 27.12 Å3 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available LC-MS/MS Spectrum - LC-ESI-qTof , Positive LC-MS/MS Not Available LC-MS/MS Spectrum - LC-ESI-qTof , Positive LC-MS/MS Not Available MS/MS Spectrum - , positive LC-MS/MS splash10-0002-2790000000-b4614b7b3adabc514ad4 MS/MS Spectrum - , positive LC-MS/MS splash10-00dj-5901100000-3131ef3fa766db3846ca
Taxonomy
- Description
- This compound belongs to the class of organic compounds known as pyridines and derivatives. These are compounds containing a pyridine ring, which is a six-member aromatic heterocycle which consists of one nitrogen atom and five carbon atoms.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Pyridines and derivatives
- Sub Class
- Not Available
- Direct Parent
- Pyridines and derivatives
- Alternative Parents
- Heteroaromatic compounds / Guanidines / Propargyl-type 1,3-dipolar organic compounds / Carboximidamides / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- Pyridine / Heteroaromatic compound / Guanidine / Azacycle / Organic 1,3-dipolar compound / Propargyl-type 1,3-dipolar organic compound / Carboximidamide / Organic nitrogen compound / Organopnictogen compound / Hydrocarbon derivative
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
Enzymes
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- CYP3A4
- Uniprot ID
- P08684
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
References
- Zhang Z, Li Y, Stearns RA, Ortiz De Montellano PR, Baillie TA, Tang W: Cytochrome P450 3A4-mediated oxidative conversion of a cyano to an amide group in the metabolism of pinacidil. Biochemistry. 2002 Feb 26;41(8):2712-8. [PubMed:11851418]
Drug created on September 14, 2010 10:21 / Updated on May 02, 2018 01:34