Guanidines

Name
Guanidines
Accession Number
DBCAT000342
Description

A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.

Drugs
DrugDrug Description
CreatineFor nutritional supplementation, also for treating dietary shortage or imbalance.
BethanidineFor the treatment of hypertension.
MetforminA biguanide drug used in conjunction with diet and exercise for glycemic control in type 2 diabetes mellitus and used off-label for insulin resistance in polycystic ovary syndrome (PCOS).
CimetidineA histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.
GuanidineA strong organic base used to treat muscle weakness and fatigue associated with the myasthenic complications of Eaton-Lambert syndrome.
ZanamivirA neuraminidase inhibitor used to treat influenza A and B.
GuanabenzAn alpha-2 adrenergic agonist used to treat hypertension.
ChlorhexidineAn antiseptic used to sterilize for surgeries and in healthcare practice, to reduce pocket depth in periodontitis, and to treat gingivitis.
PhenforminFor the reatment of type II diabetes mellitus.
GuanfacineAn alpha-2A adrenergic receptor agonist used to treat ADHD.
ProguanilA medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria.
GuanethidineAn antihypertensive agent used in the management of moderate and severe hypertension, either alone or as an adjunct, and for the management of renal hypertension.
BuforminBuformin is an anti-diabetic drug of the biguanide class, chemically related to metformin and phenformin. It was withdrawn from the market in most countries due to a high risk of...
IobenguaneA radiopharmaceutical agent used for the diagnosis of primary and metastatic pheochromocytoma or neuroblastoma.
PinacidilPinacidil is a cyanoguanidine drug that acts by opening ATP-sensitive potassium channels, leading to peripheral vasodilatation of arterioles and decreasing peripheral vascular resistance. The above processes result in reduced blood...
AgmatineAgmatine is being studied experimentally for several indications such as cardioprotection, diabetes, decreased kidney function, neuroprotection (stroke, severe CNS injuries, epilepsy, glaucoma, and neuropathic pain), and psychiatric conditions (depression, anxiety,...
Laninamivir octanoateLaninamivir octanoate has been used in trials studying the treatment of Asthma.
PolihexanidePolihexanide has been used in trials studying the treatment, prevention, and supportive care of Caries, Neoplasm, Skin Diseases, Nail Diseases, and Dental Plaque, among others.
ChlorproguanilChlorproguanil has been used in trials studying the treatment of MALARIA. It is a dichloro-derivative of chloroguanide.
LaninamivirLaninamivir has been used in trials studying the treatment of Influenza.
GabexateNo approved indication.
MitoguazoneMitoguazone has been used in trials studying the treatment of Lymphoma, HIV Infections, and Lymphoma, Non-Hodgkin.
PhosphocreatinePhosphocreatine is a naturally occuring substance that is found predominantly in the skeletal muscles of vertebrates. Its primary utility within the body is to serve in the maintanence and recycling...
GuanoxabenzNot Annotated
GuanazodineNot Annotated
AmbazoneNot Annotated
SulfaguanidineNot Annotated
CamostatA serine protease indicated in Japan to treat chronic pancreatitis.
CycloguanilCycloguanil is the active metabolite of proguanil.
Polyaminopropyl biguanideNot Annotated
Drugs & Drug Targets
DrugTargetType
CreatineSodium- and chloride-dependent creatine transporter 1target
CreatineGuanidinoacetate N-methyltransferasetarget
CreatineCreatine kinase M-typetarget
CreatineCreatine kinase U-type, mitochondrialtarget
CreatineCreatine kinase B-typetarget
CreatineCreatine kinase S-type, mitochondrialtarget
CreatineSolute carrier family 22 member 5transporter
BethanidineAlpha-2 adrenergic receptorstarget
BethanidineATP-sensitive inward rectifier potassium channel 1target
BethanidineBeta adrenergic receptortarget
Metformin5'-AMP-activated protein kinase subunit beta-1target
MetforminSolute carrier family 22 member 2transporter
MetforminSolute carrier family 22 member 1transporter
MetforminMultidrug and toxin extrusion protein 1transporter
MetforminEquilibrative nucleoside transporter 4transporter
MetforminSolute carrier family 22 member 3transporter
MetforminMultidrug and toxin extrusion protein 2transporter
MetforminElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialtarget
MetforminGlycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmictarget
CimetidineHistamine H2 receptortarget
CimetidineCytochrome P450 1A2enzyme
CimetidineCytochrome P450 2D6enzyme
CimetidineCytochrome P450 2C19enzyme
CimetidineCytochrome P450 3A4enzyme
CimetidineCytochrome P450 3A5enzyme
CimetidineP-glycoprotein 1transporter
CimetidineSolute carrier family 22 member 2transporter
CimetidineSolute carrier family 22 member 1transporter
CimetidineSolute carrier family 22 member 3transporter
CimetidineSolute carrier family 22 member 5transporter
CimetidineSolute carrier family 22 member 6transporter
CimetidineSolute carrier family 22 member 8transporter
CimetidineMultidrug and toxin extrusion protein 1transporter
CimetidineSolute carrier family 22 member 4transporter
CimetidineSolute carrier family 22 member 11transporter
CimetidineSolute carrier family 22 member 7transporter
CimetidineCytochrome P450 11B1, mitochondrialenzyme
CimetidineCytochrome P450 2C8enzyme
CimetidineCytochrome P450 2C9enzyme
CimetidineCytochrome P450 2E1enzyme
CimetidineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
CimetidineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
CimetidineBile salt export pumptransporter
CimetidineMultidrug and toxin extrusion protein 2transporter
GuanidineRibonuclease pancreatictarget
GuanidineDNAtarget
GuanidineDisks large homolog 4target
GuanidineLysozymetarget
GuanidineAldehyde dehydrogenase, mitochondrialtarget
GuanidineGuanidinoacetate N-methyltransferasetarget
GuanidineArginasetarget
GuanidineSolute carrier family 22 member 2transporter
GuanidineSolute carrier family 22 member 1transporter
GuanidineSolute carrier family 22 member 3transporter
GuanidineSolute carrier family 22 member 5transporter
GuanidineSolute carrier family 22 member 8transporter
GuanidineSolute carrier family 22 member 4transporter
GuanidineMultidrug and toxin extrusion protein 1transporter
GuanidineMultidrug and toxin extrusion protein 2transporter
ZanamivirNeuraminidasetarget
ZanamivirNeuraminidasetarget
ZanamivirSialidase-2target
GuanabenzAlpha-2A adrenergic receptortarget
GuanabenzCytochrome P450 1A2enzyme
GuanabenzAlpha-2B adrenergic receptortarget
ChlorhexidineBacterial outer membranetarget
ChlorhexidineSerum albumincarrier
Phenformin5'-AMP-activated protein kinase catalytic subunit alpha-1target
PhenforminCytochrome P450 2D6enzyme
PhenforminSolute carrier family 22 member 2transporter
PhenforminSolute carrier family 22 member 1transporter
PhenforminATP-sensitive inward rectifier potassium channel 8target
GuanfacineAlpha-2A adrenergic receptortarget
GuanfacineCytochrome P450 2C19enzyme
GuanfacineCytochrome P450 3A4enzyme
GuanfacineAlpha-2B adrenergic receptortarget
GuanfacineMultidrug and toxin extrusion protein 1transporter
GuanfacineSolute carrier family 22 member 1transporter
GuanfacineSolute carrier family 22 member 2transporter
ProguanilBifunctional dihydrofolate reductase-thymidylate synthasetarget
ProguanilDihydrofolate reductasetarget
ProguanilCytochrome P450 2C19enzyme
ProguanilCytochrome P450 2D6enzyme
ProguanilCytochrome P450 2C9enzyme
GuanethidineSodium-dependent noradrenaline transportertarget
BuforminSolute carrier family 22 member 1transporter
IobenguaneSodium-dependent noradrenaline transportertransporter
PinacidilCytochrome P450 3A4enzyme
AgmatineSolute carrier family 22 member 1transporter
AgmatineSolute carrier family 22 member 2transporter
AgmatineSolute carrier family 22 member 3transporter
AgmatineAlpha-2C adrenergic receptortarget
AgmatineNischarintarget
AgmatineAcetylcholine receptor subunit alphatarget
AgmatineGlutamate receptor ionotropic, NMDA 1target
AgmatineATP-sensitive inward rectifier potassium channel 1target
AgmatineVoltage-dependent N-type calcium channel subunit alpha-1Btarget
AgmatineAcid-sensing ion channel 3target
AgmatineY+L amino acid transporter 1transporter
AgmatineCytochrome P450 3A4enzyme
GabexateTrypsin-1enzyme
GabexateComplement C1s subcomponentenzyme
GabexateComplement C1r subcomponentenzyme
GabexatePlasma kallikreintarget
GabexateProthrombintarget
GabexatePlasminogentarget
PhosphocreatineGuanidinoacetate N-methyltransferasetarget
PhosphocreatineSodium- and chloride-dependent creatine transporter 1target
PhosphocreatineCreatine kinase M-typetarget
PhosphocreatineCreatine kinase U-type, mitochondrialtarget
PhosphocreatineCreatine kinase S-type, mitochondrialtarget
PhosphocreatineCreatine kinase B-typetarget
CamostatTrypsin-1target
CamostatTransmembrane protease serine 2target
CamostatSuppressor of tumorigenicity 14 proteintarget
CamostatCholecystokinintarget