Name
Amidines
Accession Number
DBCAT000343
Description

Derivatives of oxoacids RnE(=O)OH in which the hydroxy group is replaced by an amino group and the oxo group is replaced by =NR. Amidines include carboxamidines, sulfinamidines and phosphinamidines.

Drugs
DrugDrug Description
CreatineFor nutritional supplementation, also for treating dietary shortage or imbalance.
BethanidineFor the treatment of hypertension.
GuanadrelUsed to treat and control hypertension.
CimetidineA histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.
GuanidineA strong organic base used to treat muscle weakness and fatigue associated with the myasthenic complications of Eaton-Lambert syndrome.
ZanamivirA neuraminidase inhibitor used to treat influenza A and B.
GuanabenzAn alpha-2 adrenergic agonist used to treat hypertension.
PentamidineAn antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV.
ChlorhexidineAn antiseptic used to sterilize for surgeries and in healthcare practice, to reduce pocket depth in periodontitis, and to treat gingivitis.
PhenforminFor the reatment of type II diabetes mellitus.
GuanfacineAn alpha-2A adrenergic receptor agonist used to treat ADHD.
ProguanilA medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria.
GuanethidineAn antihypertensive agent used in the management of moderate and severe hypertension, either alone or as an adjunct, and for the management of renal hypertension.
2-butyl-1-hydroxyguanidineNot Available
BenzamidineNot Available
DiminazeneDiminazene, also known as Diminazine, 4,4'-(Diazoamino)benzamidine, 4,4'-(1-triazene-1,3-diyl)bis-benzenecarboximidamide, diminazine aceturate, or Diminazene aceturate, is a trypanocidal agent. Major brands of Diminazene are Berenil, Pirocide, Ganasag, and Azidin. This substance is a...
SC45647Not Available
BuforminBuformin is an anti-diabetic drug of the biguanide class, chemically related to metformin and phenformin. It was withdrawn from the market in most countries due to a high risk of...
GMX1777Intended for the treatment of solid tumors and lymphomas.
CariporideInvestigated for use/treatment in cardiac surgery.
PafuramidineInvestigated for use/treatment in pneumonia, trypanosomiasis, malaria, HIV infection, and infectious and parasitic disease (unspecified).
BrostallicinInvestigated for use/treatment in solid tumors.
PeramivirAn intravenous antiviral agent used to treat acute uncomplicated influenza in patients aged 2 years and older who are shown to be symptomatic for no more than two days.
IobenguaneA radiopharmaceutical agent used for the diagnosis of primary and metastatic pheochromocytoma or neuroblastoma.
PinacidilPinacidil is a cyanoguanidine drug that acts by opening ATP-sensitive potassium channels, leading to peripheral vasodilatation of arterioles and decreasing peripheral vascular resistance. The above processes result in reduced blood...
AgmatineAgmatine is being studied experimentally for several indications such as cardioprotection, diabetes, decreased kidney function, neuroprotection (stroke, severe CNS injuries, epilepsy, glaucoma, and neuropathic pain), and psychiatric conditions (depression, anxiety,...
FebantelNot Annotated
Laninamivir octanoateLaninamivir octanoate has been used in trials studying the treatment of Asthma.
PolihexanidePolihexanide has been used in trials studying the treatment, prevention, and supportive care of Caries, Neoplasm, Skin Diseases, Nail Diseases, and Dental Plaque, among others.
ChlorproguanilChlorproguanil has been used in trials studying the treatment of MALARIA. It is a dichloro-derivative of chloroguanide.
NafamostatUsed as an anticoagulant in patients with disseminative blood vessel coagulation, hemorrhagic lesions, and hemorrhagic tendencies. It prevents blood clot formation during extracorporeal circulation in patients undergoing continuous renal replacement...
GusperimusGusperimus has been used in trials studying the treatment of Lupus Nephritis, Wegeners Granulomatosis, and Wegener's Granulomatosis.
LaninamivirLaninamivir has been used in trials studying the treatment of Influenza.
GabexateNo approved indication.
MitoguazoneMitoguazone has been used in trials studying the treatment of Lymphoma, HIV Infections, and Lymphoma, Non-Hodgkin.
CHS-828CHS-828 has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.
DeoxyspergualinDeoxyspergualin has been used in trials studying the treatment of Lupus Nephritis, Chronic Rejection, and Diabetes Mellitus, Type 1.
PhosphocreatinePhosphocreatine is a naturally occuring substance that is found predominantly in the skeletal muscles of vertebrates. Its primary utility within the body is to serve in the maintanence and recycling...
GuanoxanGuanoxan is an antihypertensive agent similar in its mechanism of action to guanethidine; may cause liver damage. Guanoxan was approved in the UK but was withdrawn from the market due...
PropamidineNot Annotated
GuanoxabenzNot Annotated
DibrompropamidineNot Annotated
GuanazodineNot Annotated
AmbazoneNot Annotated
SulfaguanidineNot Annotated
CamostatA serine protease indicated in Japan to treat chronic pancreatitis.
GuanoclorNot Annotated
DiphenylguanidineDiphenylguanidine is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years...
MetforminA biguanide drug used in conjunction with diet and exercise for glycemic control in type 2 diabetes mellitus and used off-label for insulin resistance in polycystic ovary syndrome (PCOS).
HexamidineNot Available
PimagedineInvestigated for use/treatment in diabetic kidney disease.
HydroxystilbamidineUsed in the treatment of nonprogressive blastomycosis of the skin and other mycoses.
CycloguanilCycloguanil is the active metabolite of proguanil.
BrilacidinBrilacidin is under investigation for the supportive care of Mucositis, Stomatitis, Mouth Diseases, and Head and Neck Neoplasms.
N-hydroxyguanidineNot Available
4-guanidinobenzoic acidNot Available
Polyaminopropyl biguanideNot Annotated
Drugs & Drug Targets
DrugTargetType
CreatineSodium- and chloride-dependent creatine transporter 1target
CreatineGuanidinoacetate N-methyltransferasetarget
CreatineCreatine kinase M-typetarget
CreatineCreatine kinase U-type, mitochondrialtarget
CreatineCreatine kinase B-typetarget
CreatineCreatine kinase S-type, mitochondrialtarget
CreatineSolute carrier family 22 member 5transporter
BethanidineAlpha-2 adrenergic receptorstarget
BethanidineATP-sensitive inward rectifier potassium channel 1target
BethanidineBeta adrenergic receptortarget
GuanadrelSodium-dependent noradrenaline transportertarget
CimetidineHistamine H2 receptortarget
CimetidineCytochrome P450 1A2enzyme
CimetidineCytochrome P450 2D6enzyme
CimetidineCytochrome P450 2C19enzyme
CimetidineCytochrome P450 3A4enzyme
CimetidineCytochrome P450 3A5enzyme
CimetidineP-glycoprotein 1transporter
CimetidineSolute carrier family 22 member 2transporter
CimetidineSolute carrier family 22 member 1transporter
CimetidineSolute carrier family 22 member 3transporter
CimetidineSolute carrier family 22 member 5transporter
CimetidineSolute carrier family 22 member 6transporter
CimetidineSolute carrier family 22 member 8transporter
CimetidineMultidrug and toxin extrusion protein 1transporter
CimetidineSolute carrier family 22 member 4transporter
CimetidineSolute carrier family 22 member 11transporter
CimetidineSolute carrier family 22 member 7transporter
CimetidineCytochrome P450 11B1, mitochondrialenzyme
CimetidineCytochrome P450 2C8enzyme
CimetidineCytochrome P450 2C9enzyme
CimetidineCytochrome P450 2E1enzyme
CimetidineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
CimetidineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
CimetidineBile salt export pumptransporter
CimetidineMultidrug and toxin extrusion protein 2transporter
GuanidineRibonuclease pancreatictarget
GuanidineDNAtarget
GuanidineDisks large homolog 4target
GuanidineLysozymetarget
GuanidineAldehyde dehydrogenase, mitochondrialtarget
GuanidineGuanidinoacetate N-methyltransferasetarget
GuanidineArginasetarget
GuanidineSolute carrier family 22 member 2transporter
GuanidineSolute carrier family 22 member 1transporter
GuanidineSolute carrier family 22 member 3transporter
GuanidineSolute carrier family 22 member 5transporter
GuanidineSolute carrier family 22 member 8transporter
GuanidineSolute carrier family 22 member 4transporter
GuanidineMultidrug and toxin extrusion protein 1transporter
GuanidineMultidrug and toxin extrusion protein 2transporter
ZanamivirNeuraminidasetarget
ZanamivirNeuraminidasetarget
ZanamivirSialidase-2target
GuanabenzAlpha-2A adrenergic receptortarget
GuanabenzCytochrome P450 1A2enzyme
GuanabenzAlpha-2B adrenergic receptortarget
PentamidineDNAtarget
PentamidineCytochrome P450 2C19enzyme
PentamidinetRNA (cytosine(38)-C(5))-methyltransferasetarget
PentamidineCytochrome P450 2D6enzyme
PentamidineCytochrome P450 1A1enzyme
PentamidineCytochrome P450 3A5enzyme
PentamidineCytochrome P450 4A11enzyme
ChlorhexidineBacterial outer membranetarget
ChlorhexidineSerum albumincarrier
Phenformin5'-AMP-activated protein kinase catalytic subunit alpha-1target
PhenforminCytochrome P450 2D6enzyme
PhenforminSolute carrier family 22 member 2transporter
PhenforminSolute carrier family 22 member 1transporter
PhenforminATP-sensitive inward rectifier potassium channel 8target
GuanfacineAlpha-2A adrenergic receptortarget
GuanfacineCytochrome P450 2C19enzyme
GuanfacineCytochrome P450 3A4enzyme
GuanfacineAlpha-2B adrenergic receptortarget
GuanfacineMultidrug and toxin extrusion protein 1transporter
GuanfacineSolute carrier family 22 member 1transporter
GuanfacineSolute carrier family 22 member 2transporter
ProguanilBifunctional dihydrofolate reductase-thymidylate synthasetarget
ProguanilDihydrofolate reductasetarget
ProguanilCytochrome P450 2C19enzyme
ProguanilCytochrome P450 2D6enzyme
ProguanilCytochrome P450 2C9enzyme
GuanethidineSodium-dependent noradrenaline transportertarget
2-butyl-1-hydroxyguanidineNitric oxide synthase, braintarget
BenzamidineUrokinase-type plasminogen activatortarget
BenzamidineTrypsin-1target
BenzamidineCasein kinase II subunit alphatarget
BenzamidineKallikrein-6target
BenzamidineTrypsin-2target
BenzamidineTrypsin-3target
BenzamidineCopper transport protein ATOX1target
BenzamidineEnoyl-CoA delta isomerase 1, mitochondrialtarget
BenzamidineTrypsintarget
BenzamidineSuppressor of tumorigenicity 14 proteintarget
BenzamidineKallikrein-1target
DiminazenePeroxiredoxin-5, mitochondrialtarget
DiminazeneHTH-type transcriptional regulator QacRtarget
DiminazeneTrypsin-1target
DiminazeneAmiloride-sensitive amine oxidase [copper-containing]target
BuforminSolute carrier family 22 member 1transporter
GMX1777Nicotinamide phosphoribosyltransferasetarget
CariporideSodium/hydrogen exchanger 1target
CariporideMyeloperoxidaseenzyme
PeramivirNeuraminidasetarget
PeramivirNeuraminidasetarget
PeramivirNeuraminidasetarget
IobenguaneSodium-dependent noradrenaline transportertransporter
PinacidilCytochrome P450 3A4enzyme
AgmatineSolute carrier family 22 member 1transporter
AgmatineSolute carrier family 22 member 2transporter
AgmatineSolute carrier family 22 member 3transporter
AgmatineAlpha-2C adrenergic receptortarget
AgmatineNischarintarget
AgmatineAcetylcholine receptor subunit alphatarget
AgmatineGlutamate receptor ionotropic, NMDA 1target
AgmatineATP-sensitive inward rectifier potassium channel 1target
AgmatineVoltage-dependent N-type calcium channel subunit alpha-1Btarget
AgmatineAcid-sensing ion channel 3target
AgmatineY+L amino acid transporter 1transporter
AgmatineCytochrome P450 3A4enzyme
NafamostatIntercellular adhesion molecule 1target
NafamostatTrypsin-1target
NafamostatKallikrein-1target
NafamostatProthrombintarget
NafamostatCoagulation factor Xtarget
NafamostatCoagulation factor XIItarget
NafamostatSolute carrier family 22 member 1transporter
NafamostatSolute carrier family 22 member 2transporter
GabexateTrypsin-1enzyme
GabexateComplement C1s subcomponentenzyme
GabexateComplement C1r subcomponentenzyme
GabexatePlasma kallikreintarget
GabexateProthrombintarget
GabexatePlasminogentarget
PhosphocreatineGuanidinoacetate N-methyltransferasetarget
PhosphocreatineSodium- and chloride-dependent creatine transporter 1target
PhosphocreatineCreatine kinase M-typetarget
PhosphocreatineCreatine kinase U-type, mitochondrialtarget
PhosphocreatineCreatine kinase S-type, mitochondrialtarget
PhosphocreatineCreatine kinase B-typetarget
CamostatTrypsin-1target
CamostatTransmembrane protease serine 2target
CamostatSuppressor of tumorigenicity 14 proteintarget
CamostatCholecystokinintarget
Metformin5'-AMP-activated protein kinase subunit beta-1target
MetforminSolute carrier family 22 member 2transporter
MetforminSolute carrier family 22 member 1transporter
MetforminMultidrug and toxin extrusion protein 1transporter
MetforminEquilibrative nucleoside transporter 4transporter
MetforminSolute carrier family 22 member 3transporter
MetforminMultidrug and toxin extrusion protein 2transporter
MetforminElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialtarget
MetforminGlycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmictarget
HexamidineHTH-type transcriptional regulator QacRtarget
HexamidineHTH-type transcriptional regulator QacRtarget
PimagedineNitric oxide synthase, inducibletarget
PimagedineAldose reductasetarget
PimagedineMetalloproteinase inhibitor 3target
PimagedineSolute carrier family 22 member 2transporter
HydroxystilbamidineDNAtarget
4-guanidinobenzoic acidComplement factor Btarget