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Identification
NameNitrous oxide
Accession NumberDB06690
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionNitrous oxide, commonly known as "laughing gas", is a chemical compound with the chemical formula N2O. At room temperature, it is a colorless non-flammable gas, with a pleasant, slightly sweet odor and taste. It is used in surgery and dentistry for its anesthetic and analgesic effects. It is known as "laughing gas" due to the euphoric effects of inhaling it, a property that has led to its recreational use as an inhalant drug [Wikipedia].
Structure
Thumb
Synonyms
Nitrious oxide
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nitrous OxideGas99 L/100LRespiratory (inhalation)Argyle Welding Supply Company, Inc.1974-01-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Air Liquide America Specialty Gases LLC1960-01-012016-10-13Us
Nitrous OxideGas99 L/100LRespiratory (inhalation)Air Source Industries Inc1992-01-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Air Liquide Healthcare America Corporation1960-01-012016-10-13Us
Nitrous OxideGas992 mL/LRespiratory (inhalation)Matheson Tri Gas, Inc.1987-01-01Not applicableUs
Nitrous OxideGas99 kg/100kgRespiratory (inhalation)Holston Gases, Inc1958-01-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Aero All Gas Company1972-10-06Not applicableUs
Nitrous OxideLiquid99 L/100LRespiratory (inhalation)Air Liquide America Specialty Gases LLC1960-01-012016-10-13Us
Nitrous OxideGas990 mL/LRespiratory (inhalation)Du Puy Oxygen & Supply Company, Inc.1954-01-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)AGL Inhalation Therapy Co.1966-01-01Not applicableUs
Nitrous OxideGas992 mL/LRespiratory (inhalation)Airgas Usa, Llc1997-11-06Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Badger Welding Supplies, Inc1955-01-01Not applicableUs
Nitrous OxideLiquid99 L/100LRespiratory (inhalation)Air Liquide Healthcare America Corporation1960-01-012016-10-22Us
Nitrous OxideGas990 mL/LRespiratory (inhalation)Industrial Gas Distributors Inc2002-01-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Nex Air, Llc1996-06-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Norco, Inc2008-09-01Not applicableUs
Nitrous OxideGas98 %Respiratory (inhalation)Matheson Gas Products Canada Inc.1988-09-271997-12-24Canada
Nitrous OxideGas990 mL/LRespiratory (inhalation)Scott Gross Company, Inc.1974-12-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Central Welding Supply Company2016-03-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Djb Gas Services, Inc2016-09-12Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Airtec Gases, Llc2004-01-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Oxarc, Inc.1977-01-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Metro Welding Supply Corporation2015-03-17Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)American Welding & Gas2014-05-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Nitrous Oxide1900-01-01Not applicableUs
Nitrous OxideGas992 mL/LRespiratory (inhalation)Red Ball Oxygen Co., Inc.1986-01-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Air Liquide America Specialty Gases LLC1960-01-012016-10-13Us
Nitrous OxideGas990 mL/LRespiratory (inhalation)Machine & Welding Supply Company Dba Arc3 Gases South1999-06-15Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Air Supply Of North Texas2009-01-01Not applicableUs
Nitrous Oxide 100%Gas100 %Respiratory (inhalation)Air Liquide Canada Inc.1911-12-31Not applicableCanada
Nitrous Oxide 99%Gas99 %Respiratory (inhalation)Air Products Canada Ltd/LtÉe.1983-12-312003-06-13Canada
Nitrous Oxide USPGas99 %Respiratory (inhalation)Liquid Carbonic Inc.1968-12-311998-06-09Canada
Nitrous Oxide USP 99%Gas99 %Respiratory (inhalation)Praxair Canada Inc1993-12-31Not applicableCanada
Nitrous Oxide, USPGas99 %Respiratory (inhalation)Linde Canada Limited1995-12-31Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nitrous OxideGas99 L/100LRespiratory (inhalation)Linde Gas North America LLC1986-06-16Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)ILMO Products Company1995-01-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Acetylene Oxygen Company1936-01-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Blue Water Industrial Products, Inc.2008-12-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Lessors, Incorporated1964-01-01Not applicableUs
Nitrous OxideLiquid99 L/100LRespiratory (inhalation)Welding & Therapy Service Inc.1971-11-01Not applicableUs
Nitrous OxideGas99 kg/100kgRespiratory (inhalation)United States Welding, Inc.1970-01-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Praxair Distribution, Inc.2007-10-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)General Welding Supply Corp.1984-01-01Not applicableUs
Nitrous OxideGas990 mL/LRectalEncompass Medical & Specialty Gases, Ltd.2008-01-02Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Crumpton Welding Supply & Equipment, Inc1990-01-01Not applicableUs
Nitrous OxideGas992 mL/LRespiratory (inhalation)Airgas Nor Pac Inc1983-01-01Not applicableUs
Nitrous OxideGas992 mL/LRespiratory (inhalation)Airgas West, Inc.1947-05-23Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Roberts Oxygen Company, Inc.1967-01-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Compressed Gases Inc1980-01-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Nordan Smith Welding Supply1995-01-04Not applicableUs
Nitrous OxideGas99 mL/LRespiratory (inhalation)Boggs Gases Div. Boggs Fire Equipment1995-09-28Not applicableUs
Nitrous OxideGas995 mL/LRespiratory (inhalation)General Air Service & Supply Co1976-11-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Strate Welding Supply Co., Inc.1949-01-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Airgas East, Inc.1991-01-15Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Capweld Inc1952-01-01Not applicableUs
Nitrous OxideGas992 mL/LRespiratory (inhalation)Airgas Intermountain Inc1985-01-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Purity Cylinder Gases Inc1938-10-20Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Roberts Oxygen Company, Inc.1967-01-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)ABCO Welding and Industrial Supply Inc.2010-05-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Fullerton Welding Supply2008-02-06Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Praxair Distribution Southeast LLC2007-10-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Linde Gas North America LLC1990-11-27Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Welding & Therapy Service, Inc1971-11-01Not applicableUs
Nitrous OxideGas995 mL/LRespiratory (inhalation)West Air Gases & Equipment, Inc.2000-01-01Not applicableUs
Nitrous OxideGas992 mL/LRespiratory (inhalation)Airgas Northern California And Nevada, Inc.1965-01-01Not applicableUs
Nitrous OxideGas995 mL/LRespiratory (inhalation)Inland Welding Supply Dba A L Compressed Gases2005-07-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Keen Compressed Gas Co. Inc.1919-01-01Not applicableUs
Nitrous OxideGas99 kg/100kgRespiratory (inhalation)Holston Gases, Inc1958-01-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Argyle Welding Supply Co. Inc.1974-01-01Not applicableUs
Nitrous Oxide SedaraGas990 mL/LRespiratory (inhalation)Linde Gas North America LLC2012-06-18Not applicableUs
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Alnox GasAir Liquide Canada Inc.
EntonoxLinde Canada Limited
Liqui-med Analgesic GasPraxair Canada Inc
Nitrous Oxide In OxygenMatheson Gas Products Canada Inc.
SaltsNot Available
Categories
UNIIK50XQU1029
CAS number10024-97-2
WeightAverage: 44.0128
Monoisotopic: 44.001062632
Chemical FormulaN2O
InChI KeyGQPLMRYTRLFLPF-UHFFFAOYSA-N
InChI
InChI=1S/N2O/c1-2-3
IUPAC Name
diazooxidane
SMILES
[O-][N+]#N
Pharmacology
IndicationNot Available
Structured Indications Not Available
PharmacodynamicsNot Available
Mechanism of actionFindings to date indicate that nitrous oxide induces opioid peptide release in the brain stem leading to the activation of descending noradrenergic neurones, which results in modulation of the nociceptive process in the spinal cord. Several receptor–effector mechanisms including dopamine receptors, α2 adrenoceptors, benzodiazepine receptors and -methyl- -aspartate (NMDA) receptors have been implicated although the relationship of one with the other is not known.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with 1,1,1,2 Tetrafluoroethane.Investigational
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Nitrous oxide.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Nitrous oxide.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Nitrous oxide.Approved
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Nitrous oxide.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Nitrous oxide.Approved, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Nitrous oxide.Approved, Illicit
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Nitrous oxide.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Nitrous oxide.Approved, Illicit, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Nitrous oxide.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Nitrous oxide.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Amperozide.Experimental
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Nitrous oxide.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Nitrous oxide.Approved
Atracurium besylateNitrous oxide may increase the neuromuscular blocking activities of Atracurium besylate.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Azaperone.Vet Approved
AzelastineNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Nitrous oxide.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Nitrous oxide.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Benzyl alcohol.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Nitrous oxide.Approved, Illicit
BrompheniramineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Brotizolam.Approved, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Nitrous oxide.Approved, Investigational
BuprenorphineNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Nitrous oxide.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Nitrous oxide.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Nitrous oxide.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Nitrous oxide.Approved, Illicit, Vet Approved
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Nitrous oxide.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Nitrous oxide.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Carisoprodol.Approved
CetirizineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Nitrous oxide.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Nitrous oxide.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Nitrous oxide.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Nitrous oxide.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Chlorphenamine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Nitrous oxide.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Nitrous oxide.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Chlorzoxazone.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Nitrous oxide.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Nitrous oxide.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clonidine.Approved
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Nitrous oxide.Approved, Illicit
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Nitrous oxide.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Nitrous oxide.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Nitrous oxide.Approved, Illicit
CyclizineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Nitrous oxide.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Nitrous oxide.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dapoxetine.Investigational
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Nitrous oxide.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Nitrous oxide.Approved
DesipramineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Nitrous oxide.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Nitrous oxide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Nitrous oxide.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Nitrous oxide.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Nitrous oxide.Approved, Illicit, Vet Approved
DifenoxinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Nitrous oxide.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Nitrous oxide.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Nitrous oxide.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Nitrous oxide.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Nitrous oxide.Approved, Illicit
DopamineNitrous oxide may increase the arrhythmogenic activities of Dopamine.Approved
DoramectinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Nitrous oxide.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Nitrous oxide.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Nitrous oxide.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Nitrous oxide.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Efavirenz.Approved, Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Nitrous oxide.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Entacapone.Approved, Investigational
EphedraEphedra may increase the arrhythmogenic activities of Nitrous oxide.Approved, Nutraceutical, Withdrawn
EphedrineEphedrine may increase the arrhythmogenic activities of Nitrous oxide.Approved
EpinephrineNitrous oxide may increase the arrhythmogenic activities of Epinephrine.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Nitrous oxide.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Nitrous oxide.Approved
EthanolNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Nitrous oxide.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Nitrous oxide.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Nitrous oxide.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Nitrous oxide.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Nitrous oxide.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Nitrous oxide.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Nitrous oxide.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Nitrous oxide.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Flibanserin.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Nitrous oxide.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Nitrous oxide.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Nitrous oxide.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Nitrous oxide.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Nitrous oxide.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Nitrous oxide.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fluticasone Propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Nitrous oxide.Approved, Investigational
FormoterolNitrous oxide may increase the arrhythmogenic activities of Formoterol.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fospropofol.Approved, Illicit
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Nitrous oxide.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Nitrous oxide.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Nitrous oxide.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Nitrous oxide.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Nitrous oxide.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Nitrous oxide.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Nitrous oxide.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Nitrous oxide.Approved
HydrocodoneNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Nitrous oxide.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Indalpine.Investigational, Withdrawn
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Nitrous oxide.Approved, Vet Approved
IsoprenalineNitrous oxide may increase the arrhythmogenic activities of Isoprenaline.Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Nitrous oxide.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Nitrous oxide.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ketobemidone.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Nitrous oxide.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Nitrous oxide.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Nitrous oxide.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Nitrous oxide.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Nitrous oxide.Approved
LofentanilThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Lofentanil.Illicit
LoratadineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Nitrous oxide.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Nitrous oxide.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Nitrous oxide.Investigational
LurasidoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Maprotiline.Approved
MeclizineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Nitrous oxide.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Melperone.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Nitrous oxide.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Nitrous oxide.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Nitrous oxide.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Nitrous oxide.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Nitrous oxide.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Nitrous oxide.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Nitrous oxide.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Nitrous oxide.Approved
MethotrimeprazineNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Nitrous oxide.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Methsuximide.Approved
MethylphenidateMethylphenidate may increase the hypertensive activities of Nitrous oxide.Approved, Investigational
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Nitrous oxide.Approved
MetyrosineNitrous oxide may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Nitrous oxide.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Investigational
MirtazapineNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MivacuriumNitrous oxide may increase the neuromuscular blocking activities of Mivacurium.Approved
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Nitrous oxide.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Nitrous oxide.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Nitrous oxide.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Nitrous oxide.Approved
NorepinephrineNitrous oxide may increase the arrhythmogenic activities of Norepinephrine.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Nitrous oxide.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Nitrous oxide.Approved
OpiumThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Opium.Approved, Illicit
OrphenadrineNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Nitrous oxide.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Nitrous oxide.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Nitrous oxide.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Nitrous oxide.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Nitrous oxide.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Nitrous oxide.Approved, Investigational, Vet Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Nitrous oxide.Approved
ParaldehydeNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Paroxetine.Approved, Investigational
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Nitrous oxide.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Nitrous oxide.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved
PerazineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Nitrous oxide.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Nitrous oxide.Approved
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Nitrous oxide.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Phenoxyethanol.Approved
PhenytoinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Nitrous oxide.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Pipamperone.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Pomalidomide.Approved
PramipexoleNitrous oxide may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Nitrous oxide.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nitrous oxide.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Nitrous oxide.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Nitrous oxide.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Nitrous oxide.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Nitrous oxide.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Promethazine.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Nitrous oxide.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Nitrous oxide.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Protriptyline.Approved
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Nitrous oxide.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Nitrous oxide.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Nitrous oxide.Approved
RacloprideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ramelteon.Approved, Investigational
RapacuroniumNitrous oxide may increase the neuromuscular blocking activities of Rapacuronium.Withdrawn
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Nitrous oxide.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Nitrous oxide.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Nitrous oxide.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Nitrous oxide.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Romifidine.Vet Approved
RopiniroleNitrous oxide may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Nitrous oxide.Approved
RotigotineNitrous oxide may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Nitrous oxide.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Nitrous oxide.Experimental
Sage 547The risk or severity of adverse effects can be increased when Nitrous oxide is combined with Sage 547.Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Nitrous oxide.Approved, Vet Approved
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Nitrous oxide.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Nitrous oxide.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved
StiripentolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Nitrous oxide.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Nitrous oxide.Approved
SuvorexantNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tasimelteon.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Nitrous oxide.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Nitrous oxide.Investigational
ThalidomideNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Nitrous oxide.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Nitrous oxide.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Nitrous oxide.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Nitrous oxide.Approved
TiagabineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tiapride.Investigational
TiletamineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tiletamine.Vet Approved
TizanidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Topiramate.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Nitrous oxide.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Nitrous oxide.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Nitrous oxide.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Nitrous oxide.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Nitrous oxide.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Nitrous oxide.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Nitrous oxide.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Triprolidine.Approved
Uc1010The risk or severity of adverse effects can be increased when Nitrous oxide is combined with Uc1010.Investigational
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Nitrous oxide.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Venlafaxine.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Vigabatrin.Approved
VortioxetineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Vortioxetine.Approved
XylazineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Nitrous oxide.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Nitrous oxide.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Zolazepam.Vet Approved
ZolpidemNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Nitrous oxide.Approved
ZotepineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Nitrous oxide.Approved, Investigational
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesN01AX63N01AX13
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9467
Blood Brain Barrier+0.9872
Caco-2 permeable+0.5561
P-glycoprotein substrateNon-substrate0.9009
P-glycoprotein inhibitor INon-inhibitor0.9747
P-glycoprotein inhibitor IINon-inhibitor0.9944
Renal organic cation transporterNon-inhibitor0.9407
CYP450 2C9 substrateNon-substrate0.8867
CYP450 2D6 substrateNon-substrate0.8789
CYP450 3A4 substrateNon-substrate0.7447
CYP450 1A2 substrateNon-inhibitor0.7496
CYP450 2C9 inhibitorNon-inhibitor0.9074
CYP450 2D6 inhibitorNon-inhibitor0.9293
CYP450 2C19 inhibitorNon-inhibitor0.9089
CYP450 3A4 inhibitorNon-inhibitor0.9871
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9435
Ames testAMES toxic0.7381
CarcinogenicityCarcinogens 0.6906
BiodegradationReady biodegradable0.9704
Rat acute toxicity2.8320 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8497
hERG inhibition (predictor II)Non-inhibitor0.971
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
GasRespiratory (inhalation)
GasRectal990 mL/L
GasRespiratory (inhalation)98 %
GasRespiratory (inhalation)99 L/100L
GasRespiratory (inhalation)99 mL/L
GasRespiratory (inhalation)99 kg/100kg
GasRespiratory (inhalation)990 mL/L
GasRespiratory (inhalation)992 mL/L
GasRespiratory (inhalation)995 mL/L
LiquidRespiratory (inhalation)99 L/100L
GasRespiratory (inhalation)100 %
GasRespiratory (inhalation)99 %
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point-90.81 °CPhysProp
boiling point-88.46 °CPhysProp
logP0.36HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
logP-0.021ChemAxon
pKa (Strongest Basic)-6.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area54.46 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity27.67 m3·mol-1ChemAxon
Polarizability2.54 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0002-9000000000-2eee7435817186856ef7View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-001j-9000000000-d1a5381e3dd214cad7abView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000t-9000000000-3ae2e01e3d626729760bView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-004l-9000000000-c53ff0d270e0310b3375View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-004i-9000000000-c8b9d8f80d3f41ad7f54View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-002f-9000000000-12c3fe456373daff732eView in MoNA
Taxonomy
DescriptionThis compound belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other nonmetals'.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassHomogeneous other non-metal compounds
Sub ClassNot Available
Direct ParentHomogeneous other non-metal compounds
Alternative Parents
Substituents
  • Homogeneous other non metal
  • Inorganic oxide
  • Acyclic compound
Molecular FrameworkAcyclic compounds
External Descriptors
Comments
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Drug created on September 02, 2008 09:56 / Updated on August 17, 2016 12:24