Nitrous oxide

Identification

Name
Nitrous oxide
Accession Number
DB06690
Type
Small Molecule
Groups
Approved, Vet Approved
Description

Nitrous oxide, commonly known as "laughing gas", is a chemical compound with the chemical formula N2O. At room temperature, it is a colorless non-flammable gas, with a pleasant, slightly sweet odor and taste. It is used in surgery and dentistry for its anesthetic and analgesic effects. It is known as "laughing gas" due to the euphoric effects of inhaling it, a property that has led to its recreational use as an inhalant drug [Wikipedia].

Structure
Thumb
Synonyms
  • Nitrious oxide
External IDs
E-942 / FEMA NO. 2779 / INS NO.942 / INS-942
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nitrous OxideGas99 L/100LRespiratory (inhalation)Air Liquide America Specialty Gases LLC1960-01-012016-10-13Us
Nitrous OxideGas990 mL/LRespiratory (inhalation)Roberts Oxygen Company, Inc.1967-01-01Not applicableUs
Nitrous OxideGas995 mL/LRespiratory (inhalation)General Air Service & Supply Co1976-11-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Air Source Industries Inc1992-01-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Nitrous Oxide1900-01-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Air Supply Of North Texas2009-01-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Aero All Gas Company1972-10-06Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Machine & Welding Supply Company Dba Arc3 Gases South1999-06-15Not applicableUs
Nitrous OxideGas992 mL/LRespiratory (inhalation)Red Ball Oxygen Co., Inc.1986-01-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Badger Welding Supplies, Inc1955-01-01Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nitrous OxideGas990 mL/LRespiratory (inhalation)Airgas East, Inc.1991-01-15Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Crumpton Welding Supply & Equipment, Inc1990-01-01Not applicableUs
Nitrous OxideGas990 mL/LRespiratory (inhalation)Nordan Smith Welding Supply1995-01-04Not applicableUs
Nitrous OxideGas99 mL/LRespiratory (inhalation)Boggs Gases Div. Boggs Fire Equipment1995-09-28Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Acetylene Oxygen Company1936-01-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Fullerton Welding Supply2008-02-06Not applicableUs
Nitrous OxideGas995 mL/LRespiratory (inhalation)Inland Welding Supply Dba A L Compressed Gases2005-07-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Keen Compressed Gas Co. Inc.1919-01-01Not applicableUs
Nitrous OxideGas99 L/100LRespiratory (inhalation)Compressed Gases Inc1980-01-01Not applicableUs
Nitrous OxideGas99 kg/100kgRespiratory (inhalation)United States Welding, Inc.1970-01-01Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Alnox GasNitrous oxide (50 %) + Oxygen (50 %)GasRespiratory (inhalation)Air Liquide Canada Inc.1995-12-31Not applicableCanada
EntonoxNitrous oxide (50 %) + Oxygen (50 %)GasRespiratory (inhalation)Linde Llc1995-12-31Not applicableCanada
Liqui-med Analgesic GasNitrous oxide (50 %) + Oxygen (50 %)GasRespiratory (inhalation)Praxair, Inc.1983-12-31Not applicableCanada
Nitrous Oxide In OxygenNitrous oxide (50 %) + Oxygen (50 %)GasRespiratory (inhalation)Matheson Gas Products Canada Inc.1982-12-311997-12-24Canada
Categories
UNII
K50XQU1029
CAS number
10024-97-2
Weight
Average: 44.0128
Monoisotopic: 44.001062632
Chemical Formula
N2O
InChI Key
GQPLMRYTRLFLPF-UHFFFAOYSA-N
InChI
InChI=1S/N2O/c1-2-3
IUPAC Name
diazooxidane
SMILES
[O-][N+]#N

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action

Findings to date indicate that nitrous oxide induces opioid peptide release in the brain stem leading to the activation of descending noradrenergic neurones, which results in modulation of the nociceptive process in the spinal cord. Several receptor–effector mechanisms including dopamine receptors, α2 adrenoceptors, benzodiazepine receptors and -methyl- -aspartate (NMDA) receptors have been implicated although the relationship of one with the other is not known.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7-NitroindazoleThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with 7-Nitroindazole.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Aceprometazine.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Agomelatine.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Alaproclate.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Nitrous oxide.Approved, Illicit
AllopregnanoloneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Allopregnanolone.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Alphacetylmethadol.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Nitrous oxide.Approved, Illicit, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Nitrous oxide.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Amperozide.Experimental
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Nitrous oxide.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Nitrous oxide.Approved
Atracurium besylateNitrous oxide may increase the neuromuscular blocking activities of Atracurium besylate.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Azaperone.Vet Approved
AzelastineNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Barbital.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Benzocaine.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Benzyl alcohol.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Brexpiprazole.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Nitrous oxide.Approved, Illicit
BromisovalThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Bromisoval.Experimental
BromperidolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Bromperidol.Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Brotizolam.Approved, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Bupivacaine.Approved, Investigational
BuprenorphineNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Nitrous oxide.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Nitrous oxide.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Butethal.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Nitrous oxide.Approved, Illicit, Vet Approved
CanertinibThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Canertinib.Investigational
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Nitrous oxide.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Carfentanil.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Carisoprodol.Approved
CetirizineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Nitrous oxide.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Chlormezanone.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Chloroprocaine.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Chlorphenamine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Nitrous oxide.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Chlorzoxazone.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Cinchocaine.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clonidine.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clopenthixol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Nitrous oxide.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clothiapine.Experimental
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Nitrous oxide.Approved
CocaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Cocaine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Nitrous oxide.Approved, Illicit
CyclizineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Nitrous oxide.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dapiprazole.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dapoxetine.Investigational
DeramciclaneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Nitrous oxide.Approved
DesipramineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dexmedetomidine.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dextropropoxyphene.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dezocine.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Nitrous oxide.Approved, Illicit, Vet Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Diethyl ether.Experimental
DifenoxinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Nitrous oxide.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dihydromorphine.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Nitrous oxide.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Nitrous oxide.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dixyrazine.Experimental
DopamineNitrous oxide may increase the arrhythmogenic activities of Dopamine.Approved
DoramectinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Drotebanol.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Dyclonine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ecgonine.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Efavirenz.Approved, Investigational
EltanoloneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Eltanolone.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Enflurane.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Entacapone.Approved, Investigational
EphedraEphedra may increase the arrhythmogenic activities of Nitrous oxide.Approved, Nutraceutical, Withdrawn
EphedrineEphedrine may increase the arrhythmogenic activities of Nitrous oxide.Approved
EpinephrineNitrous oxide may increase the arrhythmogenic activities of Epinephrine.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Nitrous oxide.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Nitrous oxide.Approved
EthanolNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ethchlorvynol.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ethyl carbamate.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ethyl chloride.Experimental
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ethylmorphine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Etomidate.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Etorphine.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fencamfamine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Nitrous oxide.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Flibanserin.Approved
FluanisoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fluanisone.Experimental
FludiazepamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Flunitrazepam.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Nitrous oxide.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Nitrous oxide.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Nitrous oxide.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fluspirilene.Approved
Fluticasone propionateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fluticasone propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fluvoxamine.Approved, Investigational
FormoterolNitrous oxide may increase the arrhythmogenic activities of Formoterol.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fospropofol.Approved, Illicit
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Nitrous oxide.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Gabapentin Enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Nitrous oxide.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Glutethimide.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Halazepam.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Nitrous oxide.Approved
HalothaneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Halothane.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Heroin.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Hexobarbital.Approved
HydrocodoneNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Nitrous oxide.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Indalpine.Investigational, Withdrawn
IndiplonThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Indiplon.Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Nitrous oxide.Approved, Vet Approved
IsoprenalineNitrous oxide may increase the arrhythmogenic activities of Isoprenaline.Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Nitrous oxide.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ketobemidone.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Levobupivacaine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Levomethadyl Acetate.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Nitrous oxide.Approved
LidocaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Lidocaine.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Lithium.Approved
LofentanilThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Lofentanil.Illicit
LoprazolamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Loprazolam.Experimental
LoratadineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Nitrous oxide.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Lormetazepam.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Nitrous oxide.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Maprotiline.Approved
MebicarThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Mebicar.Experimental
MeclizineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Meclizine.Approved
MedazepamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Melatonin.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Melperone.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Mepivacaine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Nitrous oxide.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Meptazinol.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Mesoridazine.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Nitrous oxide.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Methadyl Acetate.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Methaqualone.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Nitrous oxide.Approved
MethotrimeprazineNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Methoxyflurane.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Methsuximide.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Methylecgonine.Experimental
MethylphenidateMethylphenidate may increase the hypertensive activities of Nitrous oxide.Approved, Investigational
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Methylphenobarbital.Approved
MetyrosineNitrous oxide may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Nitrous oxide.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Investigational
MirtazapineNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MivacuriumNitrous oxide may increase the neuromuscular blocking activities of Mivacurium.Approved
MolindoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Molindone.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Nitrous oxide.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Nitrous oxide.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Nitrous oxide.Approved
NorepinephrineNitrous oxide may increase the arrhythmogenic activities of Norepinephrine.Approved
NorfluraneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Norflurane.Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Nitrous oxide.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ondansetron.Approved
OpiumThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Opium.Approved, Illicit
OrphenadrineNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Osanetant.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Nitrous oxide.Approved
OxethazaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Oxethazaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Oxybuprocaine.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Nitrous oxide.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Nitrous oxide.Approved, Investigational, Vet Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Nitrous oxide.Approved
ParaldehydeNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Paroxetine.Approved, Investigational
PenfluridolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Penfluridol.Experimental
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Nitrous oxide.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Nitrous oxide.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved
PerazineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Nitrous oxide.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Nitrous oxide.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Phenazocine.Experimental
PhenibutThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Phenibut.Experimental
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Nitrous oxide.Approved
PhenoperidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Phenoperidine.Experimental
PhenoxyethanolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Phenoxyethanol.Approved
PhenytoinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Nitrous oxide.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Pipamperone.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Pomalidomide.Approved
PramipexoleNitrous oxide may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Prazepam.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nitrous oxide.Approved, Illicit, Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Prilocaine.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Procaine.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Nitrous oxide.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Nitrous oxide.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Promethazine.Approved
PropanididThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Propanidid.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Proparacaine.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Nitrous oxide.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Protriptyline.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when Nitrous oxide is combined with PSD502.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Nitrous oxide.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Nitrous oxide.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ramelteon.Approved, Investigational
RapacuroniumNitrous oxide may increase the neuromuscular blocking activities of Rapacuronium.Withdrawn
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Nitrous oxide.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Remoxipride.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Nitrous oxide.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Nitrous oxide.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Romifidine.Vet Approved
RopiniroleNitrous oxide may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ropivacaine.Approved
RotigotineNitrous oxide may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Nitrous oxide.Approved
ScopolamineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Nitrous oxide.Approved, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Sepranolone.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Sertindole.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Nitrous oxide.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved
StiripentolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Nitrous oxide.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Sulpiride.Approved
SultoprideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Sultopride.Experimental
SuvorexantNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tasimelteon.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Nitrous oxide.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tetracaine.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tetrahydropalmatine.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tetrodotoxin.Investigational
ThalidomideNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Thiamylal.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Thiopental.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Nitrous oxide.Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Nitrous oxide.Approved
TiagabineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tiapride.Approved, Investigational
TiletamineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tilidine.Experimental
TizanidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Topiramate.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Nitrous oxide.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tranylcypromine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Trazodone.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Nitrous oxide.Approved
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Tricaine methanesulfonate.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Trichloroethylene.Experimental
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Nitrous oxide.Approved
TrifluperidolThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Triflupromazine.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Triprolidine.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Valproic Acid.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Veralipride.Experimental
VigabatrinThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Vigabatrin.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Vinyl ether.Experimental
VortioxetineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Vortioxetine.Approved
XenonThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Xenon.Experimental
XylazineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Nitrous oxide.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Nitrous oxide.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Zolazepam.Vet Approved
ZolpidemNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Nitrous oxide.Approved
ZotepineThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Nitrous oxide.Approved, Investigational
Food Interactions
Not Available

References

Synthesis Reference
Not Available
General References
Not Available
External Links
Human Metabolome Database
HMDB35807
KEGG Drug
D00102
KEGG Compound
C00887
PubChem Compound
948
PubChem Substance
310264877
ChemSpider
923
ChEBI
17045
ChEMBL
CHEMBL1234579
PharmGKB
PA450645
HET
N2O
Wikipedia
Nitrous_oxide
ATC Codes
N01AX63 — Nitrous oxide, combinationsN01AX13 — Nitrous oxide
AHFS Codes
Not Available
PDB Entries
Not Available
FDA label
Not Available
MSDS
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentAnxiety Disease1
0RecruitingTreatmentBipolar Depressive Disorder / Bipolar Disorder (BD) / Treatment- Resistant Bipolar Disorder1
1Active Not RecruitingBasic ScienceHealthy Volunteers1
1CompletedTreatmentHyperalgesia1
1RecruitingTreatmentDepressive Disorder, Treatment-Resistant / Major Depressive Disorder (MDD)1
1TerminatedTreatmentPeripheral Vein Vasodilation1
2Active Not RecruitingTreatmentDepressive State / Major Depressive Disorder (MDD)1
2CompletedNot AvailableAlcohol-Related Disorders / Opioid-Related Disorders / Substance-Related Disorders1
2CompletedTreatmentOpioid-Related Disorders / Substance-Related Disorders2
2RecruitingTreatmentBipolar Disorder (BD)1
2RecruitingTreatmentDepressive Disorder, Treatment-Resistant / Major Depressive Disorder (MDD)1
2RecruitingTreatmentSickle Cell Disorders / Vaso-Occlusive Crises1
2SuspendedTreatmentLabour Pain1
2, 3Not Yet RecruitingTreatmentAnalgesia, Obstetrical / Obstetrical Anesthesia / Postpartum Depression1
3CompletedPreventionColorectal Cancers1
3CompletedTreatmentComplications, Pregnancy / Complications; Cesarean Section / Fetus or Neonate Affected by External Version Before Labor / Inhalation of Nitrous Oxide / Non-cephalic Presentation1
3CompletedTreatmentInjection Site Vesicles1
3TerminatedPreventionPain1
3Unknown StatusTreatmentFiberoptic Bronchoscopy1
3WithdrawnNot AvailableAnalgesic Affect1
4CompletedBasic ScienceAdjunct to general anesthesia therapy / Adverse Effects / Nitrous Oxide1
4CompletedDiagnosticDepth of Anaesthesia1
4CompletedDiagnosticGlaucoma / Sedation therapy1
4CompletedPreventionCoronary Artery Disease1
4CompletedPreventionEffects of Nitrous Oxide Following Anaesthesia / Induced Endothelial Dysfunction / Quality of Recovery From Anaesthesia1
4CompletedTreatmentAnaesthesia therapy1
4CompletedTreatmentAnalgesia / Bowel Cancer Screening / Colonoscopy / Entonox1
4CompletedTreatmentFeeling Anxious / Pain1
4CompletedTreatmentPain1
4CompletedTreatmentPulmonary Function Under Anaesthesia1
4Not Yet RecruitingOtherLumbar Punctures / Minor Incision Drainage of Abscesses Not Requiring Extensive Debridement / Sedation, Conscious / Simple Lacerations Less Than 4 cm1
4Not Yet RecruitingTreatmentSafety and Efficacy of Intranasal Dexmedetomidine1
4RecruitingTreatmentAnaesthesia therapy / Delirium, Dementia, Amnestic, Cognitive Disorders1
4SuspendedTreatmentPatients Requiring Diagnostic Gastroscopy Suitable for Sedation / Patients Requiring Diagnostic Gastroscopy With Sedation1
4WithdrawnTreatmentAbscesses / Laceration1
Not AvailableActive Not RecruitingSupportive CareAbdominal Hysterectomy (& Wertheim) / Adjunct to general anesthesia therapy / Nitrous Oxide1
Not AvailableCompletedNot AvailableAmnesia1
Not AvailableCompletedNot AvailableOpioid-Related Disorders / Substance-Related Disorders5
Not AvailableCompletedDiagnosticCoronary Artery Disease / Major Surgery1
Not AvailableCompletedHealth Services ResearchAdjunct to general anesthesia therapy / Deep Sedation1
Not AvailableCompletedOtherPregnancy Termination in Second Trimester1
Not AvailableCompletedPreventionCardiovascular Abnormalities1
Not AvailableCompletedTreatmentAbscesses / Laceration1
Not AvailableCompletedTreatmentMigraines / Pain1
Not AvailableCompletedTreatmentOpioid-Related Disorders / Substance-Related Disorders1
Not AvailableNot Yet RecruitingTreatmentColonic Neoplasms1
Not AvailableNot Yet RecruitingTreatmentFeeling Anxious1
Not AvailableRecruitingSupportive CareInguinal Herniorrhaphy / Post Operative Pain1
Not AvailableRecruitingTreatmentAbscesses / Joint dislocations / Perianal Abscess1
Not AvailableRecruitingTreatmentLabour Pain1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
GasRespiratory (inhalation)
GasRectal990 mL/L
GasRespiratory (inhalation)98 %
GasRespiratory (inhalation)99 L/100L
GasRespiratory (inhalation)99 mL/L
GasRespiratory (inhalation)99 kg/100kg
GasRespiratory (inhalation)990 mL/L
GasRespiratory (inhalation)992 mL/L
GasRespiratory (inhalation)995 mL/L
LiquidRespiratory (inhalation)99 L/100L
GasRespiratory (inhalation)100 %
GasRespiratory (inhalation)99 %
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)-90.81 °CPhysProp
boiling point (°C)-88.46 °CPhysProp
logP0.36HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
logP-0.021ChemAxon
pKa (Strongest Basic)-6.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area54.46 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity27.67 m3·mol-1ChemAxon
Polarizability2.54 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9467
Blood Brain Barrier+0.9872
Caco-2 permeable+0.5561
P-glycoprotein substrateNon-substrate0.9009
P-glycoprotein inhibitor INon-inhibitor0.9747
P-glycoprotein inhibitor IINon-inhibitor0.9944
Renal organic cation transporterNon-inhibitor0.9407
CYP450 2C9 substrateNon-substrate0.8867
CYP450 2D6 substrateNon-substrate0.8789
CYP450 3A4 substrateNon-substrate0.7447
CYP450 1A2 substrateNon-inhibitor0.7496
CYP450 2C9 inhibitorNon-inhibitor0.9074
CYP450 2D6 inhibitorNon-inhibitor0.9293
CYP450 2C19 inhibitorNon-inhibitor0.9089
CYP450 3A4 inhibitorNon-inhibitor0.9871
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9435
Ames testAMES toxic0.7381
CarcinogenicityCarcinogens 0.6906
BiodegradationReady biodegradable0.9704
Rat acute toxicity2.8320 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8497
hERG inhibition (predictor II)Non-inhibitor0.971
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-9000000000-2eee7435817186856ef7
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-001j-9000000000-d1a5381e3dd214cad7ab
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-000t-9000000000-3ae2e01e3d626729760b
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004l-9000000000-c53ff0d270e0310b3375
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-c8b9d8f80d3f41ad7f54
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-002f-9000000000-12c3fe456373daff732e

Taxonomy

Description
This compound belongs to the class of chemical entities known as other non-metal nitrides. These are inorganic compounds of nitrogen where nitrogen has a formal oxidation state of -3, and the heaviest atom bonded to it belongs to the class of 'other non-metals'.
Kingdom
Chemical entities
Super Class
Inorganic compounds
Class
Homogeneous non-metal compounds
Sub Class
Other non-metal organides
Direct Parent
Other non-metal nitrides
Alternative Parents
Inorganic oxides / Inorganic nitrides
Substituents
Other non-metal nitride / Inorganic nitride / Inorganic oxide
Molecular Framework
Not Available
External Descriptors
nitrogen oxide (CHEBI:17045 ) / a non-metabolic compound (NITROUS-OXIDE )

Drug created on September 02, 2008 09:56 / Updated on October 02, 2017 05:46