Hydracarbazine

Identification

Name
Hydracarbazine
Accession Number
DB09243
Type
Small Molecule
Groups
Experimental
Description

Hydracarbazine is a pyridazine that has found use as an antihypertensive agent [1] It was once marketed in France under the tradename Normatensyl.

Structure
Thumb
Synonyms
Not Available
External IDs
TH-2151
Categories
UNII
6CTK2FB9QM
CAS number
3614-47-9
Weight
Average: 153.145
Monoisotopic: 153.065059865
Chemical Formula
C5H7N5O
InChI Key
WRYZEGZNBYOMLE-UHFFFAOYSA-N
InChI
InChI=1S/C5H7N5O/c6-5(11)3-1-2-4(8-7)10-9-3/h1-2H,7H2,(H2,6,11)(H,8,10)
IUPAC Name
6-hydrazinylpyridazine-3-carboxamide
SMILES
[H]N([H])N([H])C1=NN=C(C=C1)C(=O)N([H])[H]

Pharmacology

Indication

Was used for the treatment of hypertension [1].

Pharmacodynamics

Relaxes vascular smooth muscle [1].

Mechanism of action

Likely acts similarly to hydralazine, a related compound, which interferes with calcium release from the sarcoplasmic reticulum in response to inositol [2].

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe risk or severity of bleeding and hemorrhage can be increased when Hydracarbazine is combined with (R)-warfarin.
(S)-WarfarinThe risk or severity of bleeding and hemorrhage can be increased when Hydracarbazine is combined with (S)-Warfarin.
2,4-thiazolidinedioneHydracarbazine may increase the hypoglycemic activities of 2,4-thiazolidinedione.
2,5-Dimethoxy-4-ethylamphetamineHydracarbazine may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamineHydracarbazine may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylthioamphetamine.
3,4-MethylenedioxyamphetamineHydracarbazine may increase the hypertensive activities of 3,4-Methylenedioxyamphetamine.
4-Bromo-2,5-dimethoxyamphetamineHydracarbazine may increase the hypertensive activities of 4-Bromo-2,5-dimethoxyamphetamine.
4-hydroxycoumarinThe risk or severity of bleeding and hemorrhage can be increased when Hydracarbazine is combined with 4-hydroxycoumarin.
4-MethoxyamphetamineHydracarbazine may increase the hypertensive activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamineThe metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Hydracarbazine.
Food Interactions
Not Available

References

General References
  1. Francis JE: Antihypertensives acting by a peripheral mechanism ACS Symposium Series. 1976 June 01;27:55-79.
  2. 22. (2012). In Rang and Dale's Pharmacology (7th ed., pp. 273). Edinburgh: Elsevier/Churchill Livingstone. [ISBN:978-0-7020-3471-8]
External Links
PubChem Compound
71653
PubChem Substance
310265146
ChemSpider
64713
ChEBI
136055
ChEMBL
CHEMBL2106246
Wikipedia
Hydracarbazine

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility9.3 mg/mLALOGPS
logP-0.95ALOGPS
logP-1ChemAxon
logS-1.2ALOGPS
pKa (Strongest Acidic)13.88ChemAxon
pKa (Strongest Basic)6.03ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area106.92 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity42.49 m3·mol-1ChemAxon
Polarizability14.15 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as 2-heteroaryl carboxamides. These are compounds containing a heteroaromatic ring that carries a carboxamide group.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Carboxylic acid derivatives
Direct Parent
2-heteroaryl carboxamides
Alternative Parents
Pyridazines and derivatives / Imidolactams / Heteroaromatic compounds / Primary carboxylic acid amides / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organic oxides / Hydrocarbon derivatives / Hydrazines and derivatives
Substituents
2-heteroaryl carboxamide / Pyridazine / Imidolactam / Heteroaromatic compound / Primary carboxylic acid amide / Organoheterocyclic compound / Azacycle / Hydrazine derivative / Organopnictogen compound / Organic oxygen compound
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available

Drug created on October 23, 2015 16:06 / Updated on November 02, 2018 07:00