|DB00752||Tranylcypromine||For the treatment of major depressive episode without melancholia.|
|DB00780||Phenelzine||Phenelzine is indicated for the treatment of nonendogenous, neurotic or atypical depression for patients that do not tolerate other forms of therapy.[L1356]
Atypical depression has a high prevalence rate, starts in early life, tends to last longer, is more likely to occur in people with bipolar disorder, has a high comorbidity with anxiety disorder and carries more risk of suicidal behavior. It is important to specify the atypical feature to predict the clinical course of depression and hence generate the best treatment and service. The featuring symptoms of the atypical feature include mood reactivity, two or more of this symptoms: 1) increased appetite, 2) increased sleep, 3) leaden paralysis and 4) interpersonal rejection sensitivity and should not have melancholic or catatonic features of depression.[A31917]
Neurotic depression is a depression of an emotionally unstable person. It is a secondary condition to major personality disorder, neuroses and drug use disorders. Likewise, a primary depression with a family history of depression spectrum disease would fit in this category.[A31922]
A nonendogenous depression is characterized by a disturbance in mood and general outlook. The physical symptoms tend to be less severe and it often occurs in response to stressful life events that keep occurring over a large period of time generating a continuous stress in the daily living.[A31924]|
|DB01037||Selegiline||Monotherapy for initial treatment of Parkinson's disease, as well as an adjunct therapy in patients with a decreased response to levodopa/carbadopa. Also used for the palliative treatment of mild to moderate Alzheimer's disease and at higher doses, for the treatment of depression.|
|DB01171||Moclobemide||For the treatment of major depressive disorder and bipolar disorder [A31901].|
|DB01247||Isocarboxazid||Isocarboxazid is indicated for the treatment of the enduring and debilitating symptoms of depression that have not responded to other antidepressant drugs.[L1372] Depression is a common but serious mood disorder. The patient will present changes in its feelings, thoughts, and ability to handle everyday activities. For a mood disorder to be considered as depression, the symptoms should be present for at least two weeks.[L1375]|
|DB01367||Rasagiline||For the treatment of the signs and symptoms of idiopathic Parkinsons disease as initial monotherapy and as adjunct therapy to levodopa.|
|DB01626||Pargyline||For the treatment of moderate to severe hypertension.|
|DB00805||Minaprine||For the treatment of depression|
|DB04818||Iproniazid||For the treatment of depression (originally intended to treat tuberculosis).|
|DB09244||Pirlindole||For the treatment of major depression.
It is being studied in the treatment of fibromyalgia pain syndrome. One study determined that the effect of pirlindole on sensorimotor performance while driving a motor vehicle shows many similarities to that of placebo. The drug appears to stimulate the central nervous system, rather than exhibit a sedative effect, like many antidepressants. Because of its selective, reversible inhibition of monoamine oxidase (MAO-A) and short half-life, unpleasant "cheese effects" are avoided. This refers to the effects of consuming tyramine-rich foods, such as cheese while medicated with monoamine oxidase inhibitors, leading to severe headaches and hypertension [L1395]. of The available evidence supports pirlindole as a safe and effective treatment option for the management of depression and fibromyalgia syndrome [L1394].
|DB09245||Toloxatone||For the treatment of major depressive disorder. |
|DB09243||Hydracarbazine||Was used for the treatment of hypertension [A19790].|
|DB09241||Methylene blue||Methylene blue has several indications in medicine:
1. found to improve the hypotension associated with various clinical states.
2. Antiseptic in urinary tract infections.
3. Improves hypoxia and hyper dynamic circulation in cirrhosis of liver and severe hepatopulmonary syndrome.
4. Results in transient and reproducible improvement in blood pressure and cardiac function in septic shock.
5. Investigated for the treatment of Alzheimer's disease.
6. Treatment of ifofosamide induced neurotoxicity.|
|DB09246||Benmoxin||For the treatment of depression.|
|DB09248||Mebanazine||For the treatment of depression.|
|DB09249||Octamoxin||For the treatment of depression.|
|DB09250||Pheniprazine||For the treatment of depression, schizophrenia, and angina pectoris.|
|DB09251||Phenoxypropazine||For the treatment of depression.|
|DB09252||Pivhydrazine||For the treatment of depression.|
|DB09253||Safrazine||For the treatment of depression.|
|DB09254||Caroxazone||For the treatment of depression.|
|DB00614||Furazolidone||For the specific and symptomatic treatment of bacterial or protozoal diarrhea and enteritis caused by susceptible organisms.|
|DB00721||Procaine||Used as a local anesthetic primarily in oral surgery|
|DB00182||Amphetamine||Amphetamine is indicated for the treatment of attention-deficit/hyperactivity disorders (ADHD) as well as for the treatment of central nervous system disorders such as narcolepsy.[A18540]
ADHD is a complex disorder associated with the substantial heterogeneity in etiology, clinical presentation, and treatment outcome. ADHD comes from a complex interplay between interdependent genetic and non-genetic factors which cause complex mental disorders in children and teenagers.[A174271]
On the other hand, narcolepsy is a chronic sleep disorder typically resenting during adolescence and characterized by excessive daytime sleepiness.[A174274]
Amphetamine is also being used nowadays off-label for the treatment of obesity, depression and chronic pain.[A174268, A174283]|
|DB01168||Procarbazine||For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.|
|DB00601||Linezolid||For the treatment of bacterial infections caused by susceptible strains of vancomycin resistant Enterococcus faecium, Staphylococcal aureus (methicillin resistant and susceptible strains), Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae.|
|DB06654||Safinamide||Safinamide is indicated as an add-on treatment to levodopa with or without other medicines for Parkinson’s disease|