Phenoxypropazine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Phenoxypropazine
Accession Number
DB09251
Type
Small Molecule
Groups
Withdrawn
Description

Phenoxypropazine is an irreversible and non-selective monoamine oxidase inhibitor (MAOI) of the hydrazine family. It was introduced as an antidepressant in 1961, but was subsequently withdrawn in 1966 due to hepatotoxicity concerns.

Structure
Thumb
Synonyms
Not Available
International/Other Brands
Drazine
Categories
UNII
8E92V52324
CAS number
3818-37-9
Weight
Average: 166.224
Monoisotopic: 166.110613079
Chemical Formula
C9H14N2O
InChI Key
QNEXFJFTGQBXBJ-UHFFFAOYSA-N
InChI
InChI=1S/C9H14N2O/c1-8(11-10)7-12-9-5-3-2-4-6-9/h2-6,8,11H,7,10H2,1H3
IUPAC Name
(1-phenoxypropan-2-yl)hydrazine
SMILES
[H]N([H])N([H])C(C)COC1=CC=CC=C1

Pharmacology

Indication

For the treatment of depression.

Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
2,5-Dimethoxy-4-ethylamphetamineThe risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Phenoxypropazine.Experimental, Illicit
2,5-Dimethoxy-4-ethylthioamphetamineThe risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylthioamphetamine is combined with Phenoxypropazine.Experimental
3,4-MethylenedioxyamphetamineThe risk or severity of adverse effects can be increased when 3,4-Methylenedioxyamphetamine is combined with Phenoxypropazine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamineThe risk or severity of adverse effects can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Phenoxypropazine.Experimental, Illicit
4-MethoxyamphetaminePhenoxypropazine may increase the hypertensive activities of 4-Methoxyamphetamine.Experimental, Illicit
5-methoxy-N,N-dimethyltryptamineThe metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Phenoxypropazine.Experimental, Illicit
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolinePhenoxypropazine may increase the hypertensive activities of 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.Experimental
AbediterolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Abediterol.Investigational
AcarbosePhenoxypropazine may increase the hypoglycemic activities of Acarbose.Approved, Investigational
AcebutololPhenoxypropazine may increase the hypotensive activities of Acebutolol.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Alaproclate is combined with Phenoxypropazine.Experimental
AlbiglutidePhenoxypropazine may increase the hypoglycemic activities of Albiglutide.Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Phenoxypropazine.Approved, Illicit
AliskirenPhenoxypropazine may increase the hypotensive activities of Aliskiren.Approved, Investigational
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Phenoxypropazine.Approved, Investigational
AlogliptinPhenoxypropazine may increase the hypoglycemic activities of Alogliptin.Approved
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Phenoxypropazine.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Alphaprodine is combined with Phenoxypropazine.Illicit
AlprenololPhenoxypropazine may increase the hypotensive activities of Alprenolol.Approved, Withdrawn
AltretamineAltretamine may increase the orthostatic hypotensive activities of Phenoxypropazine.Approved
AmbrisentanPhenoxypropazine may increase the hypotensive activities of Ambrisentan.Approved, Investigational
AmineptinePhenoxypropazine may increase the serotonergic activities of Amineptine.Illicit, Withdrawn
AmitriptylinePhenoxypropazine may increase the serotonergic activities of Amitriptyline.Approved
AmitriptylinoxidePhenoxypropazine may increase the serotonergic activities of Amitriptylinoxide.Approved, Investigational
AmlodipinePhenoxypropazine may increase the hypotensive activities of Amlodipine.Approved
AmoxapinePhenoxypropazine may increase the serotonergic activities of Amoxapine.Approved
AmphetamineThe risk or severity of adverse effects can be increased when Amphetamine is combined with Phenoxypropazine.Approved, Illicit, Investigational
ApomorphineThe metabolism of Apomorphine can be decreased when combined with Phenoxypropazine.Approved, Investigational
ApraclonidineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Apraclonidine.Approved
ArbutamineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Arbutamine.Approved
ArformoterolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Arformoterol.Approved, Investigational
AtenololPhenoxypropazine may increase the hypotensive activities of Atenolol.Approved
AtomoxetinePhenoxypropazine may increase the central neurotoxic activities of Atomoxetine.Approved
AtropinePhenoxypropazine may increase the hypertensive activities of Atropine.Approved, Vet Approved
BambuterolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Bambuterol.Approved, Investigational
BenazeprilPhenoxypropazine may increase the hypotensive activities of Benazepril.Approved, Investigational
BendroflumethiazidePhenoxypropazine may increase the hypotensive activities of Bendroflumethiazide.Approved
BenmoxinBenmoxin may increase the hypertensive activities of Phenoxypropazine.Withdrawn
BenzphetamineThe risk or severity of adverse effects can be increased when Benzphetamine is combined with Phenoxypropazine.Approved, Illicit
BepridilPhenoxypropazine may increase the hypotensive activities of Bepridil.Approved, Withdrawn
BetahistineThe serum concentration of Betahistine can be increased when it is combined with Phenoxypropazine.Approved, Investigational
BetaxololPhenoxypropazine may increase the hypotensive activities of Betaxolol.Approved, Investigational
BethanidinePhenoxypropazine may increase the hypotensive activities of Bethanidine.Approved
BezafibrateThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Bezafibrate.Approved, Investigational
BietaserpinePhenoxypropazine may increase the hypotensive activities of Bietaserpine.Experimental
BimatoprostPhenoxypropazine may increase the hypotensive activities of Bimatoprost.Approved, Investigational
BisoprololPhenoxypropazine may increase the hypotensive activities of Bisoprolol.Approved
BitolterolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Bitolterol.Withdrawn
BosentanPhenoxypropazine may increase the hypotensive activities of Bosentan.Approved, Investigational
BQ-123Phenoxypropazine may increase the hypotensive activities of BQ-123.Investigational
BretyliumPhenoxypropazine may increase the hypotensive activities of Bretylium.Approved
BrexpiprazoleThe metabolism of Brexpiprazole can be decreased when combined with Phenoxypropazine.Approved, Investigational
BrimonidineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Brimonidine.Approved
BrofarominePhenoxypropazine may increase the hypertensive activities of Brofaromine.Experimental
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Phenoxypropazine.Approved, Investigational
BupranololPhenoxypropazine may increase the hypotensive activities of Bupranolol.Approved
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Phenoxypropazine.Approved, Illicit, Investigational, Vet Approved
BupropionThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Bupropion.Approved
BuspironeThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Buspirone.Approved, Investigational
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Phenoxypropazine.Approved, Illicit, Vet Approved
ButriptylinePhenoxypropazine may increase the serotonergic activities of Butriptyline.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Phenoxypropazine.Approved
CadralazinePhenoxypropazine may increase the hypotensive activities of Cadralazine.Experimental
CafedrinePhenoxypropazine may increase the hypotensive activities of Cafedrine.Investigational
CanagliflozinPhenoxypropazine may increase the hypoglycemic activities of Canagliflozin.Approved
CandesartanPhenoxypropazine may increase the hypotensive activities of Candesartan.Experimental
Candesartan cilexetilPhenoxypropazine may increase the hypotensive activities of Candesartan cilexetil.Approved
CandoxatrilPhenoxypropazine may increase the hypotensive activities of Candoxatril.Experimental
CaptoprilPhenoxypropazine may increase the hypotensive activities of Captopril.Approved
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Phenoxypropazine.Approved, Investigational
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Phenoxypropazine.Illicit, Investigational, Vet Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Phenoxypropazine.Approved, Investigational
CaroxazonePhenoxypropazine may increase the hypertensive activities of Caroxazone.Withdrawn
CarteololPhenoxypropazine may increase the hypotensive activities of Carteolol.Approved
CarvedilolPhenoxypropazine may increase the hypotensive activities of Carvedilol.Approved, Investigational
CeliprololPhenoxypropazine may increase the hypotensive activities of Celiprolol.Approved, Investigational
ChlorothiazidePhenoxypropazine may increase the hypotensive activities of Chlorothiazide.Approved, Vet Approved
ChlorphentermineThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Phenoxypropazine.Illicit, Withdrawn
ChlorpropamidePhenoxypropazine may increase the hypoglycemic activities of Chlorpropamide.Approved, Investigational
ChlorthalidonePhenoxypropazine may increase the hypotensive activities of Chlorthalidone.Approved
CicletaninePhenoxypropazine may increase the hypotensive activities of Cicletanine.Investigational
CilazaprilPhenoxypropazine may increase the hypotensive activities of Cilazapril.Approved
CinitaprideThe metabolism of Cinitapride can be decreased when combined with Phenoxypropazine.Approved, Investigational
CirazolinePhenoxypropazine may increase the hypertensive activities of Cirazoline.Experimental
CitalopramThe risk or severity of adverse effects can be increased when Citalopram is combined with Phenoxypropazine.Approved
ClemastinePhenoxypropazine may increase the anticholinergic activities of Clemastine.Approved, Investigational
ClenbuterolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Clenbuterol.Approved, Investigational, Vet Approved
ClomipraminePhenoxypropazine may increase the serotonergic activities of Clomipramine.Approved, Investigational, Vet Approved
ClonidinePhenoxypropazine may increase the hypertensive activities of Clonidine.Approved
CloranololPhenoxypropazine may increase the hypotensive activities of Cloranolol.Experimental
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Phenoxypropazine.Approved, Illicit
CryptenaminePhenoxypropazine may increase the hypotensive activities of Cryptenamine.Approved
CyclobenzaprineCyclobenzaprine may increase the serotonergic activities of Phenoxypropazine.Approved
CyclopenthiazidePhenoxypropazine may increase the hypotensive activities of Cyclopenthiazide.Experimental
CyclothiazidePhenoxypropazine may increase the hypotensive activities of Cyclothiazide.Approved
CyproheptadinePhenoxypropazine may increase the anticholinergic activities of Cyproheptadine.Approved
DapagliflozinPhenoxypropazine may increase the hypoglycemic activities of Dapagliflozin.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Dapoxetine is combined with Phenoxypropazine.Investigational
DebrisoquinPhenoxypropazine may increase the hypotensive activities of Debrisoquin.Approved, Investigational
DelaprilPhenoxypropazine may increase the hypotensive activities of Delapril.Experimental
DeserpidinePhenoxypropazine may increase the hypotensive activities of Deserpidine.Approved
DesipraminePhenoxypropazine may increase the serotonergic activities of Desipramine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Desvenlafaxine is combined with Phenoxypropazine.Approved, Investigational
DeutetrabenazineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Deutetrabenazine.Approved, Investigational
DexmethylphenidatePhenoxypropazine may increase the hypertensive activities of Dexmethylphenidate.Approved, Investigational
DextroamphetamineThe risk or severity of adverse effects can be increased when Dextroamphetamine is combined with Phenoxypropazine.Approved, Illicit
DextromethorphanPhenoxypropazine may increase the serotonergic activities of Dextromethorphan.Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Phenoxypropazine.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Phenoxypropazine.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Phenoxypropazine.Approved, Investigational
DiazoxidePhenoxypropazine may increase the hypotensive activities of Diazoxide.Approved
DibenzepinPhenoxypropazine may increase the serotonergic activities of Dibenzepin.Experimental
DiethylnorsperminePhenoxypropazine may increase the hypotensive activities of Diethylnorspermine.Investigational
DiethylpropionPhenoxypropazine may increase the hypertensive activities of Diethylpropion.Approved, Illicit
DihydralazinePhenoxypropazine may increase the hypotensive activities of Dihydralazine.Approved, Investigational
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Phenoxypropazine.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Phenoxypropazine.Approved, Investigational
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Phenoxypropazine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Phenoxypropazine.Experimental, Illicit
DiltiazemPhenoxypropazine may increase the hypotensive activities of Diltiazem.Approved, Investigational
DimetacrinePhenoxypropazine may increase the serotonergic activities of Dimetacrine.Approved, Withdrawn
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Phenoxypropazine.Approved, Illicit
DipivefrinPhenoxypropazine may increase the hypertensive activities of Dipivefrin.Approved
DisopyramidePhenoxypropazine may increase the hypoglycemic activities of Disopyramide.Approved
DisulfiramThe risk or severity of convulsion can be increased when Phenoxypropazine is combined with Disulfiram.Approved
DobutamineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Dobutamine.Approved
DomperidoneThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Domperidone.Approved, Investigational, Vet Approved
DorzolamidePhenoxypropazine may increase the hypotensive activities of Dorzolamide.Approved
DosulepinPhenoxypropazine may increase the serotonergic activities of Dosulepin.Approved
DoxapramPhenoxypropazine may increase the hypertensive activities of Doxapram.Approved, Vet Approved
DoxazosinPhenoxypropazine may increase the hypotensive activities of Doxazosin.Approved
DoxepinPhenoxypropazine may increase the serotonergic activities of Doxepin.Approved, Investigational
DoxofyllineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Doxofylline.Approved, Investigational
DoxylaminePhenoxypropazine may increase the anticholinergic activities of Doxylamine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Phenoxypropazine.Experimental
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Phenoxypropazine.Experimental, Illicit
DroxidopaPhenoxypropazine may increase the hypertensive activities of Droxidopa.Approved, Investigational
DulaglutidePhenoxypropazine may increase the hypoglycemic activities of Dulaglutide.Approved, Investigational
DuloxetineThe risk or severity of adverse effects can be increased when Duloxetine is combined with Phenoxypropazine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Phenoxypropazine.Experimental, Illicit
EfonidipinePhenoxypropazine may increase the hypotensive activities of Efonidipine.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Phenoxypropazine.Approved, Investigational
EmpagliflozinPhenoxypropazine may increase the hypoglycemic activities of Empagliflozin.Approved
EnalaprilPhenoxypropazine may increase the hypotensive activities of Enalapril.Approved, Vet Approved
EnalaprilatPhenoxypropazine may increase the hypotensive activities of Enalaprilat.Approved
EndralazinePhenoxypropazine may increase the hypotensive activities of Endralazine.Experimental
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Phenoxypropazine.Approved, Investigational
EpanololPhenoxypropazine may increase the hypotensive activities of Epanolol.Experimental
EphedraThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Ephedra.Approved, Nutraceutical, Withdrawn
EpinephrinePhenoxypropazine may increase the hypertensive activities of Epinephrine.Approved, Vet Approved
EpoprostenolPhenoxypropazine may increase the hypotensive activities of Epoprostenol.Approved
EprosartanPhenoxypropazine may increase the hypotensive activities of Eprosartan.Approved
ErgonovinePhenoxypropazine may increase the hypertensive activities of Ergonovine.Approved
ErgotaminePhenoxypropazine may increase the hypertensive activities of Ergotamine.Approved
EscitalopramThe risk or severity of adverse effects can be increased when Escitalopram is combined with Phenoxypropazine.Approved, Investigational
EtafedrineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Etafedrine.Approved
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Phenoxypropazine.Approved
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Phenoxypropazine.Approved, Illicit
EtoperidoneThe risk or severity of adverse effects can be increased when Etoperidone is combined with Phenoxypropazine.Withdrawn
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Phenoxypropazine.Illicit, Vet Approved
ExenatidePhenoxypropazine may increase the hypoglycemic activities of Exenatide.Approved, Investigational
FelodipinePhenoxypropazine may increase the hypotensive activities of Felodipine.Approved, Investigational
FenfluraminePhenoxypropazine may increase the serotonergic activities of Fenfluramine.Approved, Illicit, Investigational, Withdrawn
FenoldopamPhenoxypropazine may increase the hypotensive activities of Fenoldopam.Approved
FenoterolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Fenoterol.Approved, Investigational
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Phenoxypropazine.Approved, Illicit, Investigational, Vet Approved
Ferulic acidPhenoxypropazine may increase the hypotensive activities of Ferulic acid.Experimental
FlibanserinThe metabolism of Flibanserin can be decreased when combined with Phenoxypropazine.Approved, Investigational
FluoxetineThe risk or severity of adverse effects can be increased when Fluoxetine is combined with Phenoxypropazine.Approved, Vet Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Phenoxypropazine.Approved, Investigational
FormoterolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Formoterol.Approved, Investigational
FosinoprilPhenoxypropazine may increase the hypotensive activities of Fosinopril.Approved
FrovatriptanThe serum concentration of Frovatriptan can be increased when it is combined with Phenoxypropazine.Approved, Investigational
FurazolidonePhenoxypropazine may increase the hypertensive activities of Furazolidone.Approved, Investigational, Vet Approved
GepefrineThe risk or severity of adverse effects can be increased when Gepefrine is combined with Phenoxypropazine.Experimental
GliclazidePhenoxypropazine may increase the hypoglycemic activities of Gliclazide.Approved
GlimepiridePhenoxypropazine may increase the hypoglycemic activities of Glimepiride.Approved
GlipizidePhenoxypropazine may increase the hypoglycemic activities of Glipizide.Approved, Investigational
GlyburidePhenoxypropazine may increase the hypoglycemic activities of Glyburide.Approved
GuanabenzPhenoxypropazine may increase the hypotensive activities of Guanabenz.Approved, Investigational
GuanadrelPhenoxypropazine may increase the hypotensive activities of Guanadrel.Approved
GuanazodinePhenoxypropazine may increase the hypotensive activities of Guanazodine.Experimental
GuanethidinePhenoxypropazine may increase the hypotensive activities of Guanethidine.Approved
GuanfacinePhenoxypropazine may increase the hypotensive activities of Guanfacine.Approved, Investigational
GuanoclorPhenoxypropazine may increase the hypotensive activities of Guanoclor.Experimental
GuanoxabenzPhenoxypropazine may increase the hypotensive activities of Guanoxabenz.Experimental
GuanoxanPhenoxypropazine may increase the hypotensive activities of Guanoxan.Experimental
HarmalinePhenoxypropazine may increase the hypertensive activities of Harmaline.Experimental
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Phenoxypropazine.Approved, Illicit, Investigational
HexamethoniumPhenoxypropazine may increase the hypotensive activities of Hexamethonium.Experimental
HexoprenalineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Hexoprenaline.Approved, Withdrawn
HydracarbazineHydracarbazine may increase the hypertensive activities of Phenoxypropazine.Experimental
HydralazinePhenoxypropazine may increase the hypotensive activities of Hydralazine.Approved
HydrochlorothiazidePhenoxypropazine may increase the hypotensive activities of Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Phenoxypropazine.Approved, Illicit
HydroflumethiazidePhenoxypropazine may increase the hypotensive activities of Hydroflumethiazide.Approved, Investigational
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Phenoxypropazine.Approved, Illicit
HydroxyamphetamineThe risk or severity of adverse effects can be increased when Hydroxyamphetamine is combined with Phenoxypropazine.Approved
ImidaprilPhenoxypropazine may increase the hypotensive activities of Imidapril.Investigational
ImipraminePhenoxypropazine may increase the serotonergic activities of Imipramine.Approved
IndacaterolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Indacaterol.Approved
IndalpineThe risk or severity of adverse effects can be increased when Indalpine is combined with Phenoxypropazine.Investigational, Withdrawn
IndapamidePhenoxypropazine may increase the hypotensive activities of Indapamide.Approved
IndenololPhenoxypropazine may increase the hypotensive activities of Indenolol.Withdrawn
IndoraminPhenoxypropazine may increase the hypotensive activities of Indoramin.Withdrawn
Insulin AspartPhenoxypropazine may increase the hypoglycemic activities of Insulin Aspart.Approved
Insulin DetemirPhenoxypropazine may increase the hypoglycemic activities of Insulin Detemir.Approved
Insulin GlarginePhenoxypropazine may increase the hypoglycemic activities of Insulin Glargine.Approved
Insulin GlulisinePhenoxypropazine may increase the hypoglycemic activities of Insulin Glulisine.Approved
Insulin HumanPhenoxypropazine may increase the hypoglycemic activities of Insulin Human.Approved, Investigational
Insulin LisproPhenoxypropazine may increase the hypoglycemic activities of Insulin Lispro.Approved
Iofetamine I-123The risk or severity of adverse effects can be increased when Iofetamine I-123 is combined with Phenoxypropazine.Approved
IprindolePhenoxypropazine may increase the serotonergic activities of Iprindole.Experimental
IproclozideIproclozide may increase the hypertensive activities of Phenoxypropazine.Withdrawn
IproniazidIproniazid may increase the hypertensive activities of Phenoxypropazine.Withdrawn
IrbesartanPhenoxypropazine may increase the hypotensive activities of Irbesartan.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypertensive activities of Phenoxypropazine.Approved
IsoetarineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Isoetarine.Approved
IsomethepteneThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Isometheptene.Approved
IsoprenalineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Isoprenaline.Approved, Investigational
IsradipinePhenoxypropazine may increase the hypotensive activities of Isradipine.Approved, Investigational
KetanserinPhenoxypropazine may increase the hypotensive activities of Ketanserin.Investigational
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Phenoxypropazine.Approved, Investigational
L-TryptophanThe risk or severity of adverse effects can be increased when L-Tryptophan is combined with Phenoxypropazine.Approved, Nutraceutical, Withdrawn
LabetalolPhenoxypropazine may increase the hypotensive activities of Labetalol.Approved
LacidipinePhenoxypropazine may increase the hypotensive activities of Lacidipine.Approved, Investigational
LatanoprostPhenoxypropazine may increase the hypotensive activities of Latanoprost.Approved, Investigational
LercanidipinePhenoxypropazine may increase the hypotensive activities of Lercanidipine.Approved, Investigational
LevodopaThe risk or severity of adverse effects can be increased when Levodopa is combined with Phenoxypropazine.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Phenoxypropazine.Approved, Investigational
LevomilnacipranThe risk or severity of adverse effects can be increased when Levomilnacipran is combined with Phenoxypropazine.Approved, Investigational
LevonordefrinPhenoxypropazine may increase the hypertensive activities of Levonordefrin.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Phenoxypropazine.Approved
LevosalbutamolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Levosalbutamol.Approved, Investigational
LinezolidThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Linezolid.Approved, Investigational
LinsidominePhenoxypropazine may increase the hypotensive activities of Linsidomine.Experimental
LiraglutidePhenoxypropazine may increase the hypoglycemic activities of Liraglutide.Approved
LisdexamfetamineThe risk or severity of adverse effects can be increased when Lisdexamfetamine is combined with Phenoxypropazine.Approved, Investigational
LisinoprilPhenoxypropazine may increase the hypotensive activities of Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Phenoxypropazine.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Lithium.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Phenoxypropazine.Illicit
LofepraminePhenoxypropazine may increase the serotonergic activities of Lofepramine.Experimental
LofexidineThe metabolism of Lofexidine can be decreased when combined with Phenoxypropazine.Approved, Investigational
LorpiprazoleThe risk or severity of serotonin syndrome can be increased when Lorpiprazole is combined with Phenoxypropazine.Approved
LosartanPhenoxypropazine may increase the hypotensive activities of Losartan.Approved
MacitentanPhenoxypropazine may increase the hypotensive activities of Macitentan.Approved
ManidipinePhenoxypropazine may increase the hypotensive activities of Manidipine.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Maprotiline.Approved, Investigational
MebanazineMebanazine may increase the hypertensive activities of Phenoxypropazine.Withdrawn
MecamylaminePhenoxypropazine may increase the hypotensive activities of Mecamylamine.Approved, Investigational
MecaserminPhenoxypropazine may increase the hypoglycemic activities of Mecasermin.Approved, Investigational
MelitracenPhenoxypropazine may increase the serotonergic activities of Melitracen.Experimental, Investigational
MephedroneThe risk or severity of adverse effects can be increased when Mephedrone is combined with Phenoxypropazine.Investigational
MephentermineThe risk or severity of adverse effects can be increased when Mephentermine is combined with Phenoxypropazine.Approved
MeptazinolThe risk or severity of adverse effects can be increased when Meptazinol is combined with Phenoxypropazine.Experimental
MequitazinePhenoxypropazine may increase the anticholinergic activities of Mequitazine.Approved
MetaraminolPhenoxypropazine may increase the hypertensive activities of Metaraminol.Approved, Investigational
MetforminPhenoxypropazine may increase the hypoglycemic activities of Metformin.Approved
MethadoneThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Phenoxypropazine.Approved, Illicit
MethamphetamineThe risk or severity of adverse effects can be increased when Methamphetamine is combined with Phenoxypropazine.Approved, Illicit
MethoserpidinePhenoxypropazine may increase the hypotensive activities of Methoserpidine.Experimental
MethoxaminePhenoxypropazine may increase the hypertensive activities of Methoxamine.Approved, Investigational
MethoxyphenamineThe risk or severity of adverse effects can be increased when Methoxyphenamine is combined with Phenoxypropazine.Experimental
MethyldopaThe risk or severity of hypertension can be increased when Phenoxypropazine is combined with Methyldopa.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Methylecgonine is combined with Phenoxypropazine.Experimental
Methylene bluePhenoxypropazine may increase the serotonergic activities of Methylene blue.Approved, Investigational
MethylphenidatePhenoxypropazine may increase the hypertensive activities of Methylphenidate.Approved, Investigational
MethysergideThe metabolism of Methysergide can be decreased when combined with Phenoxypropazine.Approved
MetipranololPhenoxypropazine may increase the hypotensive activities of Metipranolol.Approved
MetolazonePhenoxypropazine may increase the hypotensive activities of Metolazone.Approved
MetoprololPhenoxypropazine may increase the hypotensive activities of Metoprolol.Approved, Investigational
MetyrosinePhenoxypropazine may increase the hypotensive activities of Metyrosine.Approved
MianserinThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Mianserin.Approved, Investigational
MibefradilPhenoxypropazine may increase the hypotensive activities of Mibefradil.Investigational, Withdrawn
MidodrinePhenoxypropazine may increase the hypertensive activities of Midodrine.Approved
MidomafetamineThe risk or severity of adverse effects can be increased when Midomafetamine is combined with Phenoxypropazine.Experimental, Illicit, Investigational
MifepristonePhenoxypropazine may increase the hypoglycemic activities of Mifepristone.Approved, Investigational
MiglitolPhenoxypropazine may increase the hypoglycemic activities of Miglitol.Approved
MilnacipranThe risk or severity of adverse effects can be increased when Milnacipran is combined with Phenoxypropazine.Approved, Investigational
MinaprineMinaprine may increase the hypertensive activities of Phenoxypropazine.Approved
MinoxidilPhenoxypropazine may increase the hypotensive activities of Minoxidil.Approved, Investigational
MirtazapineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Mirtazapine.Approved
MMDAThe risk or severity of adverse effects can be increased when MMDA is combined with Phenoxypropazine.Experimental, Illicit
MoclobemideThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Moclobemide.Approved, Investigational
MoexiprilPhenoxypropazine may increase the hypotensive activities of Moexipril.Approved
MorphineThe therapeutic efficacy of Morphine can be increased when used in combination with Phenoxypropazine.Approved, Investigational
MoxonidinePhenoxypropazine may increase the hypotensive activities of Moxonidine.Approved, Investigational
MuzoliminePhenoxypropazine may increase the hypotensive activities of Muzolimine.Experimental
NadololPhenoxypropazine may increase the hypotensive activities of Nadolol.Approved
NaftopidilPhenoxypropazine may increase the hypotensive activities of Naftopidil.Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Phenoxypropazine.Approved
NaluzotanThe metabolism of Naluzotan can be decreased when combined with Phenoxypropazine.Investigational
NaphazolinePhenoxypropazine may increase the hypertensive activities of Naphazoline.Approved
NaratriptanThe serum concentration of Naratriptan can be increased when it is combined with Phenoxypropazine.Approved, Investigational
NateglinidePhenoxypropazine may increase the hypoglycemic activities of Nateglinide.Approved, Investigational
NebivololPhenoxypropazine may increase the hypotensive activities of Nebivolol.Approved, Investigational
NefazodoneThe risk or severity of adverse effects can be increased when Nefazodone is combined with Phenoxypropazine.Approved, Withdrawn
NialamideNialamide may increase the hypertensive activities of Phenoxypropazine.Withdrawn
NicardipinePhenoxypropazine may increase the hypotensive activities of Nicardipine.Approved, Investigational
NicorandilPhenoxypropazine may increase the hypotensive activities of Nicorandil.Approved, Investigational
NiguldipinePhenoxypropazine may increase the hypotensive activities of Niguldipine.Experimental
NilvadipinePhenoxypropazine may increase the hypotensive activities of Nilvadipine.Approved, Investigational
NimodipinePhenoxypropazine may increase the hypotensive activities of Nimodipine.Approved, Investigational
NisoldipinePhenoxypropazine may increase the hypotensive activities of Nisoldipine.Approved
NitrendipinePhenoxypropazine may increase the hypotensive activities of Nitrendipine.Approved, Investigational
NitroprussidePhenoxypropazine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
NorepinephrinePhenoxypropazine may increase the hypertensive activities of Norepinephrine.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Phenoxypropazine.Approved, Illicit
NortriptylinePhenoxypropazine may increase the serotonergic activities of Nortriptyline.Approved
OctamoxinOctamoxin may increase the hypertensive activities of Phenoxypropazine.Withdrawn
OlanzapinePhenoxypropazine may increase the serotonergic activities of Olanzapine.Approved, Investigational
OlmesartanPhenoxypropazine may increase the hypotensive activities of Olmesartan.Approved, Investigational
OlodaterolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Olodaterol.Approved
OmapatrilatPhenoxypropazine may increase the hypotensive activities of Omapatrilat.Investigational
OpipramolPhenoxypropazine may increase the serotonergic activities of Opipramol.Investigational
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Phenoxypropazine.Approved, Illicit
OrciprenalineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Orciprenaline.Approved
OxprenololPhenoxypropazine may increase the hypotensive activities of Oxprenolol.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Oxycodone.Approved, Illicit, Investigational
OxymetazolinePhenoxypropazine may increase the hypertensive activities of Oxymetazoline.Approved, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Phenoxypropazine.Approved, Investigational, Vet Approved
PargylinePargyline may increase the hypertensive activities of Phenoxypropazine.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Paroxetine is combined with Phenoxypropazine.Approved, Investigational
PenbutololPhenoxypropazine may increase the hypotensive activities of Penbutolol.Approved, Investigational
PentamidinePhenoxypropazine may increase the hypoglycemic activities of Pentamidine.Approved, Investigational
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Phenoxypropazine.Approved, Vet Approved
PentoliniumPhenoxypropazine may increase the hypotensive activities of Pentolinium.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Phenoxypropazine.Approved, Investigational, Vet Approved, Withdrawn
PerindoprilPhenoxypropazine may increase the hypotensive activities of Perindopril.Approved
PethidinePhenoxypropazine may increase the hypotensive and central nervous system depressant (CNS depressant) activities of Pethidine.Approved
PF-00610355The risk or severity of adverse effects can be increased when Phenoxypropazine is combined with PF-00610355.Investigational
PhenazocineThe risk or severity of adverse effects can be increased when Phenazocine is combined with Phenoxypropazine.Experimental
PhendimetrazinePhenoxypropazine may increase the hypertensive activities of Phendimetrazine.Approved, Illicit
PhenelzinePhenelzine may increase the hypertensive activities of Phenoxypropazine.Approved
PheniprazinePheniprazine may increase the hypertensive activities of Phenoxypropazine.Withdrawn
PhenoperidineThe risk or severity of adverse effects can be increased when Phenoperidine is combined with Phenoxypropazine.Experimental
PhenoxybenzaminePhenoxypropazine may increase the hypotensive activities of Phenoxybenzamine.Approved
PhentermineThe risk or severity of adverse effects can be increased when Phentermine is combined with Phenoxypropazine.Approved, Illicit
PhentolaminePhenoxypropazine may increase the hypotensive activities of Phentolamine.Approved
PhenylephrinePhenoxypropazine may increase the hypertensive activities of Phenylephrine.Approved
PhenylpropanolamineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Phenylpropanolamine.Approved, Vet Approved, Withdrawn
PholcodinePholcodine may increase the serotonergic activities of Phenoxypropazine.Approved, Illicit
PiclozotanThe metabolism of Piclozotan can be decreased when combined with Phenoxypropazine.Investigational
PinacidilPhenoxypropazine may increase the hypotensive activities of Pinacidil.Approved
PindololPhenoxypropazine may increase the hypotensive activities of Pindolol.Approved, Investigational
PioglitazonePhenoxypropazine may increase the hypoglycemic activities of Pioglitazone.Approved, Investigational
PirbuterolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Pirbuterol.Approved
PiritramideThe risk or severity of adverse effects can be increased when Piritramide is combined with Phenoxypropazine.Approved, Investigational
PirlindolePirlindole may increase the hypertensive activities of Phenoxypropazine.Approved
PivhydrazinePhenoxypropazine may increase the hypertensive activities of Pivhydrazine.Withdrawn
PizotifenPhenoxypropazine may increase the anticholinergic activities of Pizotifen.Approved
Platelet Activating FactorPhenoxypropazine may increase the hypotensive activities of Platelet Activating Factor.Experimental
PolythiazidePhenoxypropazine may increase the hypotensive activities of Polythiazide.Approved
PramlintidePhenoxypropazine may increase the hypoglycemic activities of Pramlintide.Approved, Investigational
PrazosinPhenoxypropazine may increase the hypotensive activities of Prazosin.Approved
ProcainePhenoxypropazine may increase the hypertensive activities of Procaine.Approved, Investigational, Vet Approved
ProcarbazinePhenoxypropazine may increase the hypertensive activities of Procarbazine.Approved, Investigational
ProcaterolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Procaterol.Approved, Investigational
PropranololPhenoxypropazine may increase the hypotensive activities of Propranolol.Approved, Investigational
ProtokylolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Protokylol.Approved, Vet Approved
ProtriptylinePhenoxypropazine may increase the serotonergic activities of Protriptyline.Approved
PseudoephedrineThe risk or severity of adverse effects can be increased when Pseudoephedrine is combined with Phenoxypropazine.Approved
QuinaprilPhenoxypropazine may increase the hypotensive activities of Quinapril.Approved, Investigational
QuininePhenoxypropazine may increase the hypoglycemic activities of Quinine.Approved
RacepinephrinePhenoxypropazine may increase the hypertensive activities of Racepinephrine.Approved
RamiprilPhenoxypropazine may increase the hypotensive activities of Ramipril.Approved
RasagilineRasagiline may increase the hypertensive activities of Phenoxypropazine.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Phenoxypropazine.Approved
RemikirenPhenoxypropazine may increase the hypotensive activities of Remikiren.Approved
RepaglinidePhenoxypropazine may increase the hypoglycemic activities of Repaglinide.Approved, Investigational
RescinnaminePhenoxypropazine may increase the hypotensive activities of Rescinnamine.Approved
ReserpineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Reserpine.Approved, Investigational
RilmenidinePhenoxypropazine may increase the hypotensive activities of Rilmenidine.Approved, Investigational
RiociguatPhenoxypropazine may increase the hypotensive activities of Riociguat.Approved
RitobegronThe risk or severity of adverse effects can be increased when Ritobegron is combined with Phenoxypropazine.Investigational
RitodrineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Ritodrine.Approved, Investigational
RizatriptanThe serum concentration of Rizatriptan can be increased when it is combined with Phenoxypropazine.Approved
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Phenoxypropazine.Approved, Investigational
RosiglitazonePhenoxypropazine may increase the hypoglycemic activities of Rosiglitazone.Approved, Investigational
RotigotineThe metabolism of Rotigotine can be decreased when combined with Phenoxypropazine.Approved
SafrazinePhenoxypropazine may increase the hypertensive activities of Safrazine.Withdrawn
SalbutamolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Salbutamol.Approved, Vet Approved
SalmeterolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Salmeterol.Approved
SaprisartanPhenoxypropazine may increase the hypotensive activities of Saprisartan.Experimental
SaxagliptinPhenoxypropazine may increase the hypoglycemic activities of Saxagliptin.Approved
SelegilineSelegiline may increase the hypertensive activities of Phenoxypropazine.Approved, Investigational, Vet Approved
SelexipagPhenoxypropazine may increase the hypotensive activities of Selexipag.Approved
SertralineThe risk or severity of adverse effects can be increased when Sertraline is combined with Phenoxypropazine.Approved
SitagliptinPhenoxypropazine may increase the hypoglycemic activities of Sitagliptin.Approved, Investigational
SitaxentanPhenoxypropazine may increase the hypotensive activities of Sitaxentan.Approved, Investigational, Withdrawn
SpiraprilPhenoxypropazine may increase the hypotensive activities of Spirapril.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Phenoxypropazine.Approved, Investigational
SulfadiazinePhenoxypropazine may increase the hypoglycemic activities of Sulfadiazine.Approved, Investigational, Vet Approved
SulfamethoxazolePhenoxypropazine may increase the hypoglycemic activities of Sulfamethoxazole.Approved
SulfisoxazolePhenoxypropazine may increase the hypoglycemic activities of Sulfisoxazole.Approved, Vet Approved
SumatriptanThe serum concentration of Sumatriptan can be increased when it is combined with Phenoxypropazine.Approved, Investigational
SunitinibPhenoxypropazine may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
TalinololPhenoxypropazine may increase the hypotensive activities of Talinolol.Investigational
TapentadolThe risk or severity of adverse effects can be increased when Tapentadol is combined with Phenoxypropazine.Approved
TelmisartanPhenoxypropazine may increase the hypotensive activities of Telmisartan.Approved, Investigational
TemocaprilPhenoxypropazine may increase the hypotensive activities of Temocapril.Experimental, Investigational
TerbutalineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Terbutaline.Approved
TerlipressinPhenoxypropazine may increase the hypotensive activities of Terlipressin.Approved, Investigational
TetrabenazineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Tetrabenazine.Approved, Investigational
TetrahydrocannabivarinThe metabolism of Tetrahydrocannabivarin can be decreased when combined with Phenoxypropazine.Investigational
TetrahydropalmatinePhenoxypropazine may increase the hypotensive activities of Tetrahydropalmatine.Investigational
TetryzolinePhenoxypropazine may increase the hypertensive activities of Tetryzoline.Approved
TheodrenalinePhenoxypropazine may increase the hypotensive activities of Theodrenaline.Investigational
TianeptineThe risk or severity of adverse effects can be increased when Tianeptine is combined with Phenoxypropazine.Approved, Investigational
TibolonePhenoxypropazine may increase the hypotensive activities of Tibolone.Approved, Investigational
TicrynafenPhenoxypropazine may increase the hypotensive activities of Ticrynafen.Withdrawn
TilidineThe risk or severity of adverse effects can be increased when Tilidine is combined with Phenoxypropazine.Experimental
TimololPhenoxypropazine may increase the hypotensive activities of Timolol.Approved
TolazamidePhenoxypropazine may increase the hypoglycemic activities of Tolazamide.Approved, Investigational
TolazolinePhenoxypropazine may increase the hypotensive activities of Tolazoline.Approved, Vet Approved
TolbutamidePhenoxypropazine may increase the hypoglycemic activities of Tolbutamide.Approved, Investigational
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Phenoxypropazine.Approved, Withdrawn
TolonidinePhenoxypropazine may increase the hypotensive activities of Tolonidine.Experimental
ToloxatoneToloxatone may increase the hypertensive activities of Phenoxypropazine.Approved
TorasemidePhenoxypropazine may increase the hypotensive activities of Torasemide.Approved
TramadolTramadol may increase the neuroexcitatory activities of Phenoxypropazine.Approved, Investigational
TrandolaprilPhenoxypropazine may increase the hypotensive activities of Trandolapril.Approved
TranylcypromineTranylcypromine may increase the hypertensive activities of Phenoxypropazine.Approved, Investigational
TravoprostPhenoxypropazine may increase the hypotensive activities of Travoprost.Approved
TrazodonePhenoxypropazine may increase the serotonergic activities of Trazodone.Approved, Investigational
TreprostinilPhenoxypropazine may increase the hypotensive activities of Treprostinil.Approved, Investigational
TrichlormethiazidePhenoxypropazine may increase the hypotensive activities of Trichlormethiazide.Approved, Vet Approved
TrimazosinPhenoxypropazine may increase the hypotensive activities of Trimazosin.Experimental
TrimethaphanPhenoxypropazine may increase the hypotensive activities of Trimethaphan.Approved, Investigational
TrimipraminePhenoxypropazine may increase the serotonergic activities of Trimipramine.Approved
UnoprostonePhenoxypropazine may increase the hypotensive activities of Unoprostone.Approved, Investigational
UrapidilPhenoxypropazine may increase the hypotensive activities of Urapidil.Investigational
ValsartanPhenoxypropazine may increase the hypotensive activities of Valsartan.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Phenoxypropazine.Approved
VilanterolThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Vilanterol.Approved
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Phenoxypropazine.Approved
VincaminePhenoxypropazine may increase the hypotensive activities of Vincamine.Experimental
VinpocetinePhenoxypropazine may increase the hypotensive activities of Vinpocetine.Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Phenoxypropazine.Approved, Investigational
XipamidePhenoxypropazine may increase the hypotensive activities of Xipamide.Experimental
XylometazolinePhenoxypropazine may increase the hypertensive activities of Xylometazoline.Approved, Investigational
ZimelidineThe risk or severity of adverse effects can be increased when Zimelidine is combined with Phenoxypropazine.Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Phenoxypropazine.Approved
ZofenoprilPhenoxypropazine may increase the hypotensive activities of Zofenopril.Experimental
ZolmitriptanThe serum concentration of Zolmitriptan can be increased when it is combined with Phenoxypropazine.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. LEAHY MR, ROSE JT, PLOWMAN R: A preliminary study of phenoxypropazine in the treatment of depression. Am J Psychiatry. 1963 Apr;119:986-7. [PubMed:13928824]
  2. IMLAH NW: Preliminary report on phenoxypropazine. Am J Psychiatry. 1963 May;119:1091-2. [PubMed:13956423]
  3. ROSE JT, LEAHY MR, PLOWMAN R: A COMPARISON OF PHENOXYPROPAZINE AND AMYTRYPTILINE IN DEPRESSION. Am J Psychiatry. 1963 Oct;120:393-5. [PubMed:14069469]
External Links
PubChem Compound
71467
PubChem Substance
310265154
ChemSpider
64548
ChEBI
134799
ChEMBL
CHEMBL1909286
Wikipedia
Phenoxypropazine

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility6.03 mg/mLALOGPS
logP1.37ALOGPS
logP1.25ChemAxon
logS-1.4ALOGPS
pKa (Strongest Basic)5.45ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area47.28 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity59.87 m3·mol-1ChemAxon
Polarizability18.67 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Phenol ethers
Sub Class
Not Available
Direct Parent
Phenol ethers
Alternative Parents
Phenoxy compounds / Alkyl aryl ethers / Alkylhydrazines / Organopnictogen compounds / Hydrocarbon derivatives
Substituents
Phenoxy compound / Phenol ether / Alkyl aryl ether / Monocyclic benzene moiety / Alkylhydrazine / Ether / Organic nitrogen compound / Organic oxygen compound / Organopnictogen compound / Hydrocarbon derivative
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available

Drug created on October 23, 2015 22:12 / Updated on June 02, 2018 08:18