Safrazine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Safrazine
Accession Number
DB09253
Type
Small Molecule
Groups
Withdrawn
Description

Safrazine (Safra) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was introduced as an antidepressant in the 1960s, but has since been discontinued.

Structure
Thumb
Synonyms
  • Safra
Categories
UNII
F5G0P5378C
CAS number
33419-68-0
Weight
Average: 208.261
Monoisotopic: 208.121177763
Chemical Formula
C11H16N2O2
InChI Key
IBWPUTAKVGZXRB-UHFFFAOYSA-N
InChI
InChI=1S/C11H16N2O2/c1-8(13-12)2-3-9-4-5-10-11(6-9)15-7-14-10/h4-6,8,13H,2-3,7,12H2,1H3
IUPAC Name
[4-(2H-1,3-benzodioxol-5-yl)butan-2-yl]hydrazine
SMILES
CC(CCC1=CC2=C(OCO2)C=C1)NN

Pharmacology

Indication

For the treatment of depression.

Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe risk or severity of bleeding and hemorrhage can be increased when Safrazine is combined with (R)-warfarin.
(S)-WarfarinThe risk or severity of bleeding and hemorrhage can be increased when Safrazine is combined with (S)-Warfarin.
2,4-thiazolidinedioneSafrazine may increase the hypoglycemic activities of 2,4-thiazolidinedione.
2,5-Dimethoxy-4-ethylamphetamineSafrazine may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamineSafrazine may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylthioamphetamine.
3,4-MethylenedioxyamphetamineSafrazine may increase the hypertensive activities of 3,4-Methylenedioxyamphetamine.
3,5-DinitrocatecholThe risk or severity of adverse effects can be increased when 3,5-Dinitrocatechol is combined with Safrazine.
4-Bromo-2,5-dimethoxyamphetamineSafrazine may increase the hypertensive activities of 4-Bromo-2,5-dimethoxyamphetamine.
4-hydroxycoumarinThe risk or severity of bleeding and hemorrhage can be increased when Safrazine is combined with 4-hydroxycoumarin.
4-MethoxyamphetamineSafrazine may increase the hypertensive activities of 4-Methoxyamphetamine.
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
34042
PubChem Substance
310265156
ChemSpider
31375
ChEMBL
CHEMBL3301845
Wikipedia
Safrazine

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility2.24 mg/mLALOGPS
logP1.51ALOGPS
logP1.69ChemAxon
logS-2ALOGPS
pKa (Strongest Basic)5.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area56.51 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity69.05 m3·mol-1ChemAxon
Polarizability23.14 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzodioxoles. These are organic compounds containing a benzene ring fused to either isomers of dioxole. Dioxole is a five-membered unsaturated ring of two oxygen atoms and three carbon atoms.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzodioxoles
Sub Class
Not Available
Direct Parent
Benzodioxoles
Alternative Parents
Benzenoids / Oxacyclic compounds / Alkylhydrazines / Acetals / Organopnictogen compounds / Hydrocarbon derivatives
Substituents
Benzodioxole / Benzenoid / Alkylhydrazine / Oxacycle / Acetal / Organic nitrogen compound / Organic oxygen compound / Organopnictogen compound / Hydrocarbon derivative / Organooxygen compound
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on October 23, 2015 22:19 / Updated on November 02, 2018 07:00