Polyestradiol phosphate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Polyestradiol phosphate
Accession Number
DB09369
Type
Small Molecule
Groups
Approved
Description

Polymeric phosphoric acid ester of estradiol.

Synonyms
  • (17-beta)-Estra-1,3,5(10)-triene-3,17-diol polymer with phosphoric acid
  • Estradiol phosphate polymer
  • Fosfato de poliestradiol
  • Oestradiol phosphate polymer
  • Phosphate de polyestradiol
  • Poly(estradiol phosphate)
  • Polyestradioli phosphas
External IDs
LEO 114 / LEO-114
International/Other Brands
Estradurin
Categories
UNII
P14877CDX2
CAS number
28014-46-2
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
AEstrogen receptor alpha
agonist
Human
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Polyestradiol phosphate.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Polyestradiol phosphate.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Polyestradiol phosphate.Experimental, Illicit
AbciximabPolyestradiol phosphate may decrease the anticoagulant activities of Abciximab.Approved
AcenocoumarolPolyestradiol phosphate may decrease the anticoagulant activities of Acenocoumarol.Approved, Investigational
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Polyestradiol phosphate.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Polyestradiol phosphate.Experimental, Investigational
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be increased when it is combined with Polyestradiol phosphate.Experimental, Investigational
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Polyestradiol phosphate.Approved
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Polyestradiol phosphate.Approved
AnastrozoleThe therapeutic efficacy of Anastrozole can be decreased when used in combination with Polyestradiol phosphate.Approved, Investigational
AncrodPolyestradiol phosphate may decrease the anticoagulant activities of Ancrod.Approved, Investigational
AndrostenedioneThe serum concentration of Androstenedione can be increased when it is combined with Polyestradiol phosphate.Experimental, Illicit
AnecortaveThe serum concentration of Anecortave can be increased when it is combined with Polyestradiol phosphate.Investigational
anecortave acetateThe serum concentration of anecortave acetate can be increased when it is combined with Polyestradiol phosphate.Investigational
Anthrax immune globulin humanPolyestradiol phosphate may increase the thrombogenic activities of Anthrax immune globulin human.Approved
Antithrombin III humanPolyestradiol phosphate may decrease the anticoagulant activities of Antithrombin III human.Approved
ApixabanPolyestradiol phosphate may decrease the anticoagulant activities of Apixaban.Approved
ArdeparinPolyestradiol phosphate may decrease the anticoagulant activities of Ardeparin.Approved, Investigational, Withdrawn
ArgatrobanPolyestradiol phosphate may decrease the anticoagulant activities of Argatroban.Approved, Investigational
AtamestaneThe serum concentration of Atamestane can be increased when it is combined with Polyestradiol phosphate.Investigational
BecaplerminPolyestradiol phosphate may decrease the anticoagulant activities of Becaplermin.Approved, Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Polyestradiol phosphate.Approved, Vet Approved
BivalirudinPolyestradiol phosphate may decrease the anticoagulant activities of Bivalirudin.Approved, Investigational
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Polyestradiol phosphate.Approved
Capromab pendetidePolyestradiol phosphate may decrease effectiveness of Capromab pendetide as a diagnostic agent.Approved
CelecoxibCelecoxib may increase the thrombogenic activities of Polyestradiol phosphate.Approved, Investigational
CertoparinPolyestradiol phosphate may decrease the anticoagulant activities of Certoparin.Approved, Investigational
Chenodeoxycholic acidThe therapeutic efficacy of Chenodeoxycholic acid can be decreased when used in combination with Polyestradiol phosphate.Approved
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational
Citric AcidPolyestradiol phosphate may decrease the anticoagulant activities of Citric Acid.Approved, Nutraceutical, Vet Approved
ClobetasolThe serum concentration of Clobetasol can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Polyestradiol phosphate.Approved
ClobetasoneThe serum concentration of Clobetasone can be increased when it is combined with Polyestradiol phosphate.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Polyestradiol phosphate.Approved
Conestat alfaPolyestradiol phosphate may increase the thrombogenic activities of Conestat alfa.Approved, Investigational
Cortexolone 17α-propionateThe serum concentration of Cortexolone 17α-propionate can be increased when it is combined with Polyestradiol phosphate.Investigational
CorticosteroneThe serum concentration of Corticosterone can be increased when it is combined with Polyestradiol phosphate.Experimental
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational
Dabigatran etexilatePolyestradiol phosphate may decrease the anticoagulant activities of Dabigatran etexilate.Approved
DalteparinPolyestradiol phosphate may decrease the anticoagulant activities of Dalteparin.Approved
DanaparoidPolyestradiol phosphate may decrease the anticoagulant activities of Danaparoid.Approved, Withdrawn
DarexabanPolyestradiol phosphate may decrease the anticoagulant activities of Darexaban.Investigational
DeflazacortThe serum concentration of Deflazacort can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational
DesirudinPolyestradiol phosphate may decrease the anticoagulant activities of Desirudin.Approved
DesonideThe serum concentration of Desonide can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Polyestradiol phosphate.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Polyestradiol phosphate.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Polyestradiol phosphate.Experimental, Vet Approved
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Polyestradiol phosphate.Vet Approved
DextranPolyestradiol phosphate may decrease the anticoagulant activities of Dextran.Approved, Investigational, Vet Approved
Dextran 40Polyestradiol phosphate may decrease the anticoagulant activities of Dextran 40.Approved
Dextran 70Polyestradiol phosphate may decrease the anticoagulant activities of Dextran 70.Approved
Dextran 75Polyestradiol phosphate may decrease the anticoagulant activities of Dextran 75.Approved
DicoumarolPolyestradiol phosphate may decrease the anticoagulant activities of Dicoumarol.Approved
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Polyestradiol phosphate.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational, Withdrawn
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Polyestradiol phosphate.Approved
DyphyllineThe serum concentration of Dyphylline can be increased when it is combined with Polyestradiol phosphate.Approved
Edetic AcidPolyestradiol phosphate may decrease the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanPolyestradiol phosphate may decrease the anticoagulant activities of Edoxaban.Approved
EnoxaparinPolyestradiol phosphate may decrease the anticoagulant activities of Enoxaparin.Approved
EquileninThe serum concentration of Equilenin can be increased when it is combined with Polyestradiol phosphate.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Polyestradiol phosphate.Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Polyestradiol phosphate.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Polyestradiol phosphate.Approved
Ethyl biscoumacetatePolyestradiol phosphate may decrease the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EtodolacEtodolac may increase the thrombogenic activities of Polyestradiol phosphate.Approved, Investigational, Vet Approved
EtoricoxibEtoricoxib may increase the thrombogenic activities of Polyestradiol phosphate.Approved, Investigational
ExemestaneThe therapeutic efficacy of Exemestane can be decreased when used in combination with Polyestradiol phosphate.Approved, Investigational
Ferulic acidPolyestradiol phosphate may decrease the anticoagulant activities of Ferulic acid.Experimental
FluasteroneThe serum concentration of Fluasterone can be increased when it is combined with Polyestradiol phosphate.Investigational
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational
FluindionePolyestradiol phosphate may decrease the anticoagulant activities of Fluindione.Approved, Investigational
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Polyestradiol phosphate.Approved, Vet Approved
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Polyestradiol phosphate.Approved, Withdrawn
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Polyestradiol phosphate.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Polyestradiol phosphate.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Polyestradiol phosphate.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Polyestradiol phosphate.Approved
Fluticasone propionateThe serum concentration of Fluticasone propionate can be increased when it is combined with Polyestradiol phosphate.Approved
FondaparinuxPolyestradiol phosphate may decrease the anticoagulant activities of Fondaparinux.Approved, Investigational
Fondaparinux sodiumPolyestradiol phosphate may decrease the anticoagulant activities of Fondaparinux sodium.Approved, Investigational
FormestaneThe serum concentration of Formestane can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational, Withdrawn
GabexatePolyestradiol phosphate may decrease the anticoagulant activities of Gabexate.Investigational
HalcinonideThe serum concentration of Halcinonide can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational, Withdrawn
HE3286The serum concentration of HE3286 can be increased when it is combined with Polyestradiol phosphate.Investigational
HeparinPolyestradiol phosphate may decrease the anticoagulant activities of Heparin.Approved, Investigational
Human C1-esterase inhibitorPolyestradiol phosphate may increase the thrombogenic activities of Human C1-esterase inhibitor.Approved
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Polyestradiol phosphate.Approved, Investigational
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Polyestradiol phosphate.Approved, Vet Approved
IdraparinuxPolyestradiol phosphate may decrease the anticoagulant activities of Idraparinux.Investigational
IstaroximeThe serum concentration of Istaroxime can be increased when it is combined with Polyestradiol phosphate.Investigational
LenalidomidePolyestradiol phosphate may increase the thrombogenic activities of Lenalidomide.Approved
LepirudinPolyestradiol phosphate may decrease the anticoagulant activities of Lepirudin.Approved
LetaxabanPolyestradiol phosphate may decrease the anticoagulant activities of Letaxaban.Investigational
LevothyroxineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Polyestradiol phosphate.Approved
LiothyronineThe therapeutic efficacy of Liothyronine can be decreased when used in combination with Polyestradiol phosphate.Approved, Vet Approved
LiotrixThe therapeutic efficacy of Liotrix can be decreased when used in combination with Polyestradiol phosphate.Approved
LoteprednolThe serum concentration of Loteprednol can be increased when it is combined with Polyestradiol phosphate.Approved
LumiracoxibLumiracoxib may increase the thrombogenic activities of Polyestradiol phosphate.Approved, Investigational
ME-609The serum concentration of ME-609 can be increased when it is combined with Polyestradiol phosphate.Investigational
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Polyestradiol phosphate.Approved
MelagatranPolyestradiol phosphate may decrease the anticoagulant activities of Melagatran.Experimental
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Polyestradiol phosphate.Vet Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Polyestradiol phosphate.Approved, Vet Approved
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Polyestradiol phosphate.Approved, Vet Approved
NabumetoneNabumetone may increase the thrombogenic activities of Polyestradiol phosphate.Approved
NadroparinPolyestradiol phosphate may decrease the anticoagulant activities of Nadroparin.Approved, Investigational
NafamostatPolyestradiol phosphate may decrease the anticoagulant activities of Nafamostat.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Polyestradiol phosphate.Investigational
Oleoyl-estroneThe serum concentration of Oleoyl-estrone can be increased when it is combined with Polyestradiol phosphate.Investigational
OspemifeneThe risk or severity of adverse effects can be increased when Polyestradiol phosphate is combined with Ospemifene.Approved, Investigational
OtamixabanPolyestradiol phosphate may decrease the anticoagulant activities of Otamixaban.Investigational
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Polyestradiol phosphate.Approved
ParecoxibParecoxib may increase the thrombogenic activities of Polyestradiol phosphate.Approved
Pentaerythritol TetranitratePolyestradiol phosphate may decrease the anticoagulant activities of Pentaerythritol Tetranitrate.Approved
Pentosan PolysulfatePolyestradiol phosphate may decrease the anticoagulant activities of Pentosan Polysulfate.Approved
PhenindionePolyestradiol phosphate may decrease the anticoagulant activities of Phenindione.Approved, Investigational
PhenprocoumonPolyestradiol phosphate may decrease the anticoagulant activities of Phenprocoumon.Approved, Investigational
PrasteroneThe risk or severity of adverse effects can be increased when Prasterone is combined with Polyestradiol phosphate.Approved, Investigational, Nutraceutical
Prasterone sulfateThe serum concentration of Prasterone sulfate can be increased when it is combined with Polyestradiol phosphate.Investigational
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Polyestradiol phosphate.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Polyestradiol phosphate.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Polyestradiol phosphate.Approved, Experimental, Investigational
Protein CPolyestradiol phosphate may decrease the anticoagulant activities of Protein C.Approved
Protein S humanPolyestradiol phosphate may decrease the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydePolyestradiol phosphate may decrease the anticoagulant activities of Protocatechualdehyde.Approved
ReviparinPolyestradiol phosphate may decrease the anticoagulant activities of Reviparin.Approved, Investigational
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Polyestradiol phosphate.Approved
RivaroxabanPolyestradiol phosphate may decrease the anticoagulant activities of Rivaroxaban.Approved
RofecoxibRofecoxib may increase the thrombogenic activities of Polyestradiol phosphate.Approved, Investigational, Withdrawn
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Polyestradiol phosphate.Approved, Investigational
SomatotropinThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Polyestradiol phosphate.Approved, Investigational
SulodexidePolyestradiol phosphate may decrease the anticoagulant activities of Sulodexide.Approved, Investigational
ThalidomidePolyestradiol phosphate may increase the thrombogenic activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Polyestradiol phosphate.Approved
Thyroid, porcineThe therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Polyestradiol phosphate.Approved
TipranavirPolyestradiol phosphate may increase the dermatologic adverse activities of Tipranavir.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Polyestradiol phosphate.Approved, Withdrawn
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Polyestradiol phosphate.Approved, Vet Approved
TroxerutinPolyestradiol phosphate may decrease the anticoagulant activities of Troxerutin.Investigational
UlobetasolThe serum concentration of Ulobetasol can be increased when it is combined with Polyestradiol phosphate.Approved
Ursodeoxycholic acidThe therapeutic efficacy of Ursodeoxycholic acid can be decreased when used in combination with Polyestradiol phosphate.Approved, Investigational
ValdecoxibValdecoxib may increase the thrombogenic activities of Polyestradiol phosphate.Approved, Investigational, Withdrawn
Vitamin CThe serum concentration of Polyestradiol phosphate can be increased when it is combined with Vitamin C.Approved, Nutraceutical
WarfarinPolyestradiol phosphate may decrease the anticoagulant activities of Warfarin.Approved
XimelagatranPolyestradiol phosphate may decrease the anticoagulant activities of Ximelagatran.Approved, Investigational, Withdrawn
Food Interactions
Not Available

References

General References
Not Available
External Links
KEGG Drug
D07434
ChEMBL
CHEMBL1201477
Wikipedia
Polyestradiol_phosphate
ATC Codes
L02AA02 — Polyestradiol phosphate

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissu...
Gene Name
ESR1
Uniprot ID
P03372
Uniprot Name
Estrogen receptor
Molecular Weight
66215.45 Da
References
  1. Mikkola A, Ruutu M, Aro J, Rannikko S, Salo J: The role of parenteral polyestradiol phosphate in the treatment of advanced prostatic cancer on the threshold of the new millennium. Ann Chir Gynaecol. 1999;88(1):18-21. [PubMed:10230677]

Drug created on November 30, 2015 12:10 / Updated on March 02, 2018 03:49