Polyestradiol phosphate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Polyestradiol phosphate
Accession Number
DB09369
Type
Small Molecule
Groups
Approved
Description

Polymeric phosphoric acid ester of estradiol.

Synonyms
  • (17-beta)-Estra-1,3,5(10)-triene-3,17-diol polymer with phosphoric acid
  • Estradiol phosphate polymer
  • Fosfato de poliestradiol
  • Oestradiol phosphate polymer
  • Phosphate de polyestradiol
  • Poly(estradiol phosphate)
  • Polyestradioli phosphas
External IDs
LEO 114 / LEO-114
International/Other Brands
Estradurin
Categories
UNII
P14877CDX2
CAS number
28014-46-2

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
AEstrogen receptor alpha
agonist
Humans
Additional Data Available
Adverse Effects

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinPolyestradiol phosphate may decrease the anticoagulant activities of (R)-warfarin.
(S)-WarfarinPolyestradiol phosphate may decrease the anticoagulant activities of (S)-Warfarin.
3,5-diiodothyropropionic acidThe therapeutic efficacy of 3,5-diiodothyropropionic acid can be decreased when used in combination with Polyestradiol phosphate.
4-hydroxycoumarinPolyestradiol phosphate may decrease the anticoagulant activities of 4-hydroxycoumarin.
AbaloparatideThe therapeutic efficacy of Abaloparatide can be decreased when used in combination with Polyestradiol phosphate.
AbciximabPolyestradiol phosphate may decrease the anticoagulant activities of Abciximab.
AbituzumabPolyestradiol phosphate may increase the thrombogenic activities of Abituzumab.
AceclofenacAceclofenac may increase the thrombogenic activities of Polyestradiol phosphate.
AcenocoumarolPolyestradiol phosphate may decrease the anticoagulant activities of Acenocoumarol.
Acetylsalicylic acidPolyestradiol phosphate may decrease the anticoagulant activities of Acetylsalicylic acid.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

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  • Evidence Level
    Evidence Level

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  • Action
    Evidence Level

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Food Interactions
Not Available

References

General References
Not Available
External Links
KEGG Drug
D07434
ChEMBL
CHEMBL1201477
Wikipedia
Polyestradiol_phosphate
ATC Codes
L02AA02 — Polyestradiol phosphate

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissu...
Gene Name
ESR1
Uniprot ID
P03372
Uniprot Name
Estrogen receptor
Molecular Weight
66215.45 Da
References
  1. Mikkola A, Ruutu M, Aro J, Rannikko S, Salo J: The role of parenteral polyestradiol phosphate in the treatment of advanced prostatic cancer on the threshold of the new millennium. Ann Chir Gynaecol. 1999;88(1):18-21. [PubMed:10230677]

Drug created on November 30, 2015 12:10 / Updated on May 01, 2019 10:54