Name
Estrogens
Accession Number
DBCAT000620
Description

Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.

ATC Classification
Drugs
DrugDrug Description
DiethylstilbestrolUsed in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery.
ChlorotrianiseneUsed to treat symptoms of menopause, deficiencies in ovary function (including underdevelopment of female sexual characteristics and some types of infertility), and in rare cases, prostate cancer. Chlorotrianisene may also...
Conjugated estrogensA mixture of estrogens used in estrogen replacement therapy for menopause and hypoestrogenism, used in the treatment of various malignancies, and used in the treatment of postmenopausal osteoporosis.
EstroneAn estrogen used to treat perimenopausal and postmenopausal symptoms.
EstradiolAn estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.
DienestrolA non steroidal estrogen used to treat atrophic vaginitis and kraurosis vulvae.
EthinylestradiolAn estradiol used as a contraceptive.
Polyestradiol phosphatePolymeric phosphoric acid ester of estradiol.
MestranolA synthetic estradiol found in oral contraceptive pills for contraception and the treatment of other conditions in the female reproductive system, such as dysmenorrhea and dysfunctional uterine bleeding.
QuinestrolUsed in hormone replacement therapy, treating symptoms of menopause such as hot flashes. Also used to treat breast and prostate cancer.
HexestrolA synthetic estrogen that has been used as a hormonal antineoplastic agent.
Synthetic Conjugated Estrogens, AA mixture of estrogens used to treat a variety of postmenopausal symptoms, including vaginal atrophy and dyspareunia.
Synthetic Conjugated Estrogens, BA mixture of estrogens used to treat a variety of postmenopausal symptoms, including vaginal dryness.
ZeranolZeranol is a non-steroidal estrogen agonist. It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. It is 3-4x...
EquolEquol has been used in trials studying the treatment of Breast Cancer.
EpimestrolNot Annotated
EstriolUsed as a test to determine the general health of an unborn fetus.
TiboloneFor the relief of post-menopausal symptoms and for the prevention of osteoporosis .
PromestrienePromestriene has been used in trials studying the prevention of Hypospadias.
MethallenestrilNot Annotated
MoxestrolNot Annotated
Estradiol acetateAn estrogen used to treat vasomotor symptoms and moderate to severe vulvar and vaginal atrophy from menopause.
Estradiol cypionateAn estradiol prodrug used to treat vasomotor symptoms and hypoestrogenisms from hypogonadism.
Estradiol valerateAn estradiol prodrug used to treat some effects of menopause, hypoestrogenism, androgen dependant carcinoma of the prostate, and in combination products for endometriosis and contraception.
Esterified estrogensA female hormone used to treat conditions related to estrogen deficiency and moderate to severe vasomotor menopausal symptoms in women.
Estrone sulfateAn estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders.
Estradiol benzoateEstradiol benzoate is not currently available in any FDA or Health Canada approved products.
Biochanin ABiochanin A is under investigation in clinical trial NCT02174666 (Isoflavone Treatment for Postmenopausal Osteopenia.).
FormononetinFormononetin is under investigation in clinical trial NCT02174666 (Isoflavone Treatment for Postmenopausal Osteopenia.).
Bisphenol ANot Available
Fluoroestradiol F-18A radiolabeled analog of estradiol used as a contrast agent in the PET imaging of estrogen receptor-positive breast cancer lesions.
Drugs & Drug Targets
DrugTargetType
DiethylstilbestrolEstrogen receptor alphatarget
DiethylstilbestrolEstrogen-related receptor gammatarget
DiethylstilbestrolTransthyretincarrier
DiethylstilbestrolCatechol O-methyltransferaseenzyme
DiethylstilbestrolCytochrome P450 19A1enzyme
DiethylstilbestrolATP-binding cassette sub-family G member 2transporter
DiethylstilbestrolP-glycoprotein 1transporter
DiethylstilbestrolEstrogen receptor betatarget
DiethylstilbestrolCytochrome P450 3A4enzyme
DiethylstilbestrolCytochrome P450 2C8enzyme
DiethylstilbestrolCytochrome P450 2C9enzyme
DiethylstilbestrolCytochrome P450 2E1enzyme
DiethylstilbestrolSteroid hormone receptor ERR1target
DiethylstilbestrolSteroid hormone receptor ERR2target
DiethylstilbestrolNuclear receptor coactivator 2target
DiethylstilbestrolNuclear receptor subfamily 1 group I member 2target
DiethylstilbestrolAndrogen receptortarget
DiethylstilbestrolSex hormone-binding globulintarget
DiethylstilbestrolSolute carrier organic anion transporter family member 1B1transporter
DiethylstilbestrolSolute carrier organic anion transporter family member 2B1transporter
DiethylstilbestrolBile salt export pumptransporter
ChlorotrianiseneEstrogen receptor alphatarget
ChlorotrianiseneCytochrome P450 19A1enzyme
Conjugated estrogensEstrogen receptor alphatarget
Conjugated estrogensCytochrome P450 3A4enzyme
Conjugated estrogensCytochrome P450 1A2enzyme
Conjugated estrogensCatechol O-methyltransferaseenzyme
Conjugated estrogensCanalicular multispecific organic anion transporter 2transporter
Conjugated estrogensMultidrug resistance-associated protein 4transporter
Conjugated estrogensMultidrug resistance-associated protein 1transporter
Conjugated estrogensSolute carrier organic anion transporter family member 1A2transporter
Conjugated estrogensSodium/bile acid cotransportertransporter
Conjugated estrogensSolute carrier family 22 member 10transporter
Conjugated estrogensSolute carrier family 22 member 8transporter
Conjugated estrogensSolute carrier organic anion transporter family member 1C1transporter
Conjugated estrogensSolute carrier organic anion transporter family member 1B1transporter
Conjugated estrogensSolute carrier organic anion transporter family member 2B1transporter
Conjugated estrogensP-glycoprotein 1transporter
Conjugated estrogensSolute carrier family 22 member 6transporter
Conjugated estrogensOrganic solute transporter subunit alphatransporter
Conjugated estrogensOrganic solute transporter subunit betatransporter
Conjugated estrogensCanalicular multispecific organic anion transporter 1transporter
Conjugated estrogensSolute carrier organic anion transporter family member 4A1transporter
Conjugated estrogensATP-binding cassette sub-family C member 11transporter
Conjugated estrogensSolute carrier organic anion transporter family member 1B3transporter
Conjugated estrogensSolute carrier family 22 member 11transporter
Conjugated estrogensSolute carrier organic anion transporter family member 3A1transporter
Conjugated estrogensATP-binding cassette sub-family G member 2transporter
Conjugated estrogensThyroxine-binding globulincarrier
Conjugated estrogensSex hormone-binding globulincarrier
Conjugated estrogensSerum albumincarrier
Conjugated estrogensEstrogen receptor betatarget
EstroneEstrogen receptor alphatarget
EstroneCytochrome P450 1A2enzyme
EstroneCytochrome P450 1A1enzyme
EstroneSerum albumincarrier
EstroneSolute carrier organic anion transporter family member 2B1transporter
EstroneP-glycoprotein 1transporter
EstroneSolute carrier organic anion transporter family member 1A2transporter
EstroneATP-binding cassette sub-family G member 2transporter
EstroneSolute carrier organic anion transporter family member 1B1transporter
EstroneCytochrome P450 3A4enzyme
EstroneCytochrome P450 1B1enzyme
EstroneCytochrome P450 2B6enzyme
EstroneCytochrome P450 2C9enzyme
EstroneCytochrome P450 2E1enzyme
EstroneCytochrome P450 3A5enzyme
EstroneEstrogen receptor betatarget
EstroneAndrogen receptortarget
EstroneCytochrome P450 19A1target
EstroneSex hormone-binding globulintarget
EstroneSolute carrier family 22 member 8transporter
EstradiolEstrogen receptor alphatarget
EstradiolNuclear receptor subfamily 1 group I member 2target
EstradiolSex hormone-binding globulincarrier
EstradiolEstrogen receptor betatarget
EstradiolCytochrome P450 1A2enzyme
EstradiolUDP-glucuronosyltransferase 1-1enzyme
EstradiolSerum albumincarrier
EstradiolFatty acid-binding protein, intestinalcarrier
EstradiolCytochrome P450 3A4enzyme
EstradiolCytochrome P450 3A5enzyme
EstradiolCytochrome P450 3A7enzyme
EstradiolSolute carrier family 22 member 2transporter
EstradiolSolute carrier family 22 member 3transporter
EstradiolMultidrug resistance-associated protein 7transporter
EstradiolSolute carrier family 22 member 11transporter
EstradiolATP-binding cassette sub-family G member 2transporter
EstradiolSolute carrier organic anion transporter family member 1B1transporter
EstradiolP-glycoprotein 1transporter
EstradiolCytochrome P450 1A1enzyme
EstradiolCytochrome P450 1B1enzyme
EstradiolCytochrome P450 2C19enzyme
EstradiolCytochrome P450 2C8enzyme
EstradiolCytochrome P450 2C9enzyme
EstradiolSolute carrier family 22 member 8transporter
EstradiolSolute carrier organic anion transporter family member 1B3transporter
EstradiolSolute carrier organic anion transporter family member 1C1transporter
EstradiolNeuronal acetylcholine receptor subunit alpha-4target
EstradiolG-protein coupled estrogen receptor 1target
EstradiolATP synthase subunit atarget
EstradiolBeclin-1target
EstradiolUDP-glucuronosyltransferase 2B15enzyme
EstradiolCatechol O-methyltransferaseenzyme
EstradiolUDP-glucuronosyltransferases (UGTs)enzyme
DienestrolEstrogen receptor alphatarget
DienestrolSex hormone-binding globulintarget
EthinylestradiolEstrogen receptor alphatarget
EthinylestradiolNuclear receptor subfamily 1 group I member 2target
EthinylestradiolCytochrome P450 3A4enzyme
EthinylestradiolCytochrome P450 2C8enzyme
EthinylestradiolBile salt export pumptransporter
EthinylestradiolSodium/bile acid cotransportertransporter
EthinylestradiolCanalicular multispecific organic anion transporter 1transporter
EthinylestradiolP-glycoprotein 1transporter
EthinylestradiolUDP-glucuronosyltransferase 1-1enzyme
EthinylestradiolCytochrome P450 2C19enzyme
EthinylestradiolUDP-glucuronosyltransferase 1-4enzyme
EthinylestradiolUDP-glucuronosyltransferase 1-9enzyme
EthinylestradiolCytochrome P450 2C9enzyme
EthinylestradiolCytochrome P450 1A2enzyme
EthinylestradiolEstrogen sulfotransferaseenzyme
EthinylestradiolSulfotransferase 1A3/1A4enzyme
EthinylestradiolCytochrome P450 3A5enzyme
EthinylestradiolUDP-glucuronosyltransferase 2B7enzyme
EthinylestradiolUDP-glucuronosyltransferase 1-3enzyme
EthinylestradiolCatechol O-methyltransferaseenzyme
EthinylestradiolSolute carrier organic anion transporter family member 1A2transporter
EthinylestradiolSerum albumincarrier
EthinylestradiolSex hormone-binding globulincarrier
Polyestradiol phosphateEstrogen receptor alphatarget
MestranolEstrogen receptor alphatarget
MestranolCytochrome P450 2C9enzyme
MestranolCytochrome P450 3A4enzyme
MestranolCytochrome P450 2C8enzyme
QuinestrolEstrogen receptor alphatarget
HexestrolAldo-keto reductase family 1 member C1target
HexestrolEstrogen receptor alphatarget
HexestrolNuclear receptor subfamily 1 group I member 2target
HexestrolNuclear receptor subfamily 1 group I member 3target
Synthetic Conjugated Estrogens, ACytochrome P450 3A4enzyme
Synthetic Conjugated Estrogens, AEstrogen receptor alphatarget
Synthetic Conjugated Estrogens, AThyroxine-binding globulincarrier
Synthetic Conjugated Estrogens, BEstrogen receptor alphatarget
Synthetic Conjugated Estrogens, BCytochrome P450 3A4enzyme
Synthetic Conjugated Estrogens, BThyroxine-binding globulincarrier
ZeranolEstrogen receptor alphatarget
ZeranolSex hormone-binding globulintarget
EquolEstrogen receptor betatarget
EquolSex hormone-binding globulintarget
EstriolEstrogen receptor alphatarget
EstriolSolute carrier organic anion transporter family member 1A2transporter
EstriolP-glycoprotein 1transporter
EstriolEstrogen receptor betatarget
EstriolSex hormone-binding globulintarget
TiboloneEstrogen receptor alphatarget
TiboloneSteryl-sulfataseenzyme
Tibolone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1enzyme
Tibolone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
TiboloneSulfotransferase 1A1enzyme
Estradiol acetateEstrogen receptor alphatarget
Estradiol acetateNuclear receptor subfamily 1 group I member 2target
Estradiol acetateSex hormone-binding globulincarrier
Estradiol acetateEstrogen receptor betatarget
Estradiol acetateCytochrome P450 1A2enzyme
Estradiol acetateUDP-glucuronosyltransferase 1-1enzyme
Estradiol acetateSerum albumincarrier
Estradiol acetateFatty acid-binding protein, intestinalcarrier
Estradiol acetateCytochrome P450 3A4enzyme
Estradiol acetateCytochrome P450 3A5enzyme
Estradiol acetateCytochrome P450 3A7enzyme
Estradiol acetateSolute carrier family 22 member 2transporter
Estradiol acetateSolute carrier family 22 member 1transporter
Estradiol acetateSolute carrier family 22 member 3transporter
Estradiol acetateSolute carrier organic anion transporter family member 2B1transporter
Estradiol acetateSolute carrier organic anion transporter family member 1A2transporter
Estradiol acetateMultidrug resistance-associated protein 7transporter
Estradiol acetateSolute carrier family 22 member 11transporter
Estradiol acetateATP-binding cassette sub-family G member 2transporter
Estradiol acetateSolute carrier organic anion transporter family member 1B1transporter
Estradiol acetateP-glycoprotein 1transporter
Estradiol acetateCytochrome P450 1A1enzyme
Estradiol acetateCytochrome P450 1B1enzyme
Estradiol acetateCytochrome P450 2C19enzyme
Estradiol acetateCytochrome P450 2C8enzyme
Estradiol acetateCytochrome P450 2C9enzyme
Estradiol acetateSolute carrier family 22 member 8transporter
Estradiol acetateSolute carrier organic anion transporter family member 1B3transporter
Estradiol acetateSolute carrier organic anion transporter family member 1C1transporter
Estradiol acetateSolute carrier organic anion transporter family member 4A1transporter
Estradiol acetateNeuronal acetylcholine receptor subunit alpha-4target
Estradiol acetateNuclear receptor coactivator 2target
Estradiol acetateG-protein coupled estrogen receptor 1target
Estradiol acetateATP synthase subunit atarget
Estradiol acetateBeclin-1target
Estradiol acetateEstradiol 17-beta-dehydrogenase 2target
Estradiol acetateEstrogen-related receptor gammatarget
Estradiol cypionateEstrogen receptor alphatarget
Estradiol cypionateNuclear receptor subfamily 1 group I member 2target
Estradiol cypionateSex hormone-binding globulincarrier
Estradiol cypionateEstrogen receptor betatarget
Estradiol cypionateCytochrome P450 1A2enzyme
Estradiol cypionateUDP-glucuronosyltransferase 1-1enzyme
Estradiol cypionateSerum albumincarrier
Estradiol cypionateFatty acid-binding protein, intestinalcarrier
Estradiol cypionateCytochrome P450 3A4enzyme
Estradiol cypionateCytochrome P450 3A5enzyme
Estradiol cypionateCytochrome P450 3A7enzyme
Estradiol cypionateSolute carrier family 22 member 2transporter
Estradiol cypionateSolute carrier family 22 member 1transporter
Estradiol cypionateSolute carrier family 22 member 3transporter
Estradiol cypionateSolute carrier organic anion transporter family member 2B1transporter
Estradiol cypionateSolute carrier organic anion transporter family member 1A2transporter
Estradiol cypionateMultidrug resistance-associated protein 7transporter
Estradiol cypionateSolute carrier family 22 member 11transporter
Estradiol cypionateATP-binding cassette sub-family G member 2transporter
Estradiol cypionateSolute carrier organic anion transporter family member 1B1transporter
Estradiol cypionateP-glycoprotein 1transporter
Estradiol cypionateCytochrome P450 1A1enzyme
Estradiol cypionateCytochrome P450 1B1enzyme
Estradiol cypionateCytochrome P450 2C19enzyme
Estradiol cypionateCytochrome P450 2C8enzyme
Estradiol cypionateCytochrome P450 2C9enzyme
Estradiol cypionateSolute carrier family 22 member 8transporter
Estradiol cypionateSolute carrier organic anion transporter family member 1B3transporter
Estradiol cypionateSolute carrier organic anion transporter family member 1C1transporter
Estradiol cypionateSolute carrier organic anion transporter family member 4A1transporter
Estradiol cypionateNeuronal acetylcholine receptor subunit alpha-4target
Estradiol cypionateNuclear receptor coactivator 2target
Estradiol cypionateG-protein coupled estrogen receptor 1target
Estradiol cypionateATP synthase subunit atarget
Estradiol cypionateBeclin-1target
Estradiol cypionateEstradiol 17-beta-dehydrogenase 2target
Estradiol cypionateEstrogen-related receptor gammatarget
Estradiol valerateEstrogen receptor alphatarget
Estradiol valerateNuclear receptor subfamily 1 group I member 2target
Estradiol valerateSex hormone-binding globulincarrier
Estradiol valerateEstrogen receptor betatarget
Estradiol valerateCytochrome P450 1A2enzyme
Estradiol valerateUDP-glucuronosyltransferase 1-1enzyme
Estradiol valerateSerum albumincarrier
Estradiol valerateFatty acid-binding protein, intestinalcarrier
Estradiol valerateCytochrome P450 3A4enzyme
Estradiol valerateCytochrome P450 3A5enzyme
Estradiol valerateCytochrome P450 3A7enzyme
Estradiol valerateSolute carrier family 22 member 2transporter
Estradiol valerateSolute carrier family 22 member 1transporter
Estradiol valerateSolute carrier family 22 member 3transporter
Estradiol valerateSolute carrier organic anion transporter family member 2B1transporter
Estradiol valerateSolute carrier organic anion transporter family member 1A2transporter
Estradiol valerateMultidrug resistance-associated protein 7transporter
Estradiol valerateSolute carrier family 22 member 11transporter
Estradiol valerateATP-binding cassette sub-family G member 2transporter
Estradiol valerateSolute carrier organic anion transporter family member 1B1transporter
Estradiol valerateP-glycoprotein 1transporter
Estradiol valerateCytochrome P450 1A1enzyme
Estradiol valerateCytochrome P450 1B1enzyme
Estradiol valerateCytochrome P450 2C19enzyme
Estradiol valerateCytochrome P450 2C8enzyme
Estradiol valerateCytochrome P450 2C9enzyme
Estradiol valerateSolute carrier family 22 member 8transporter
Estradiol valerateSolute carrier organic anion transporter family member 1B3transporter
Estradiol valerateSolute carrier organic anion transporter family member 1C1transporter
Estradiol valerateSolute carrier organic anion transporter family member 4A1transporter
Estradiol valerateNeuronal acetylcholine receptor subunit alpha-4target
Estradiol valerateNuclear receptor coactivator 2target
Estradiol valerateG-protein coupled estrogen receptor 1target
Estradiol valerateATP synthase subunit atarget
Estradiol valerateBeclin-1target
Estradiol valerateEstradiol 17-beta-dehydrogenase 2target
Estradiol valerateEstrogen-related receptor gammatarget
Esterified estrogensCytochrome P450 3A4enzyme
Esterified estrogensThyroxine-binding globulincarrier
Estrone sulfateCytochrome P450 1A2enzyme
Estrone sulfateCytochrome P450 3A4enzyme
Estrone sulfateEstrogen receptor alphatarget
Estrone sulfateEstrogen receptor betatarget
Estrone sulfateSex hormone-binding globulincarrier
Estrone sulfateSerum albumincarrier
Estrone sulfateCytochrome P450 2C9enzyme
Estrone sulfateMultidrug and toxin extrusion protein 1transporter
Estrone sulfateMultidrug and toxin extrusion protein 2transporter
Estradiol benzoateEstrogen receptor alphatarget
Estradiol benzoateNuclear receptor subfamily 1 group I member 2target
Estradiol benzoateSex hormone-binding globulincarrier
Estradiol benzoateEstrogen receptor betatarget
Estradiol benzoateCytochrome P450 1A2enzyme
Estradiol benzoateUDP-glucuronosyltransferase 1-1enzyme
Estradiol benzoateSerum albumincarrier
Estradiol benzoateFatty acid-binding protein, intestinalcarrier
Estradiol benzoateCytochrome P450 3A4enzyme
Estradiol benzoateCytochrome P450 3A5enzyme
Estradiol benzoateCytochrome P450 3A7enzyme
Estradiol benzoateSolute carrier family 22 member 2transporter
Estradiol benzoateSolute carrier family 22 member 1transporter
Estradiol benzoateSolute carrier family 22 member 3transporter
Estradiol benzoateSolute carrier organic anion transporter family member 2B1transporter
Estradiol benzoateSolute carrier organic anion transporter family member 1A2transporter
Estradiol benzoateMultidrug resistance-associated protein 7transporter
Estradiol benzoateSolute carrier family 22 member 11transporter
Estradiol benzoateATP-binding cassette sub-family G member 2transporter
Estradiol benzoateSolute carrier organic anion transporter family member 1B1transporter
Estradiol benzoateP-glycoprotein 1transporter
Estradiol benzoateCytochrome P450 1A1enzyme
Estradiol benzoateCytochrome P450 1B1enzyme
Estradiol benzoateCytochrome P450 2C19enzyme
Estradiol benzoateCytochrome P450 2C8enzyme
Estradiol benzoateCytochrome P450 2C9enzyme
Estradiol benzoateSolute carrier family 22 member 8transporter
Estradiol benzoateSolute carrier organic anion transporter family member 1B3transporter
Estradiol benzoateSolute carrier organic anion transporter family member 1C1transporter
Estradiol benzoateSolute carrier organic anion transporter family member 4A1transporter
Estradiol benzoateNeuronal acetylcholine receptor subunit alpha-4target
Estradiol benzoateNuclear receptor coactivator 2target
Estradiol benzoateG-protein coupled estrogen receptor 1target
Estradiol benzoateATP synthase subunit atarget
Estradiol benzoateBeclin-1target
Estradiol benzoateEstradiol 17-beta-dehydrogenase 2target
Estradiol benzoateEstrogen-related receptor gammatarget
Bisphenol AEstrogen-related receptor gammatarget
Fluoroestradiol F-18Estrogen receptor alphatarget
Fluoroestradiol F-18Estrogen receptor betatarget
Fluoroestradiol F-18Sex hormone-binding globulincarrier
Fluoroestradiol F-18Serum albumincarrier