- Estradiol Congeners
- Accession Number
Steroidal compounds related to ESTRADIOL, the major mammalian female sex hormone. Estradiol congeners include important estradiol precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with estrogenic activities.
Drug Drug Description Conjugated estrogens A mixture of estrogens used in estrogen replacement therapy for menopause and hypoestrogenism, used in the treatment of various malignancies, and used in the treatment of postmenopausal osteoporosis. Estrone An estrogen used to treat perimenopausal and postmenopausal symptoms. Estradiol An estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. Fulvestrant An estrogen receptor antagonist used to treat HR+ breast cancer that may also be HER2-. Ethinylestradiol An estradiol used as a contraceptive. Estramustine An antineoplastic agent used for the management of metastatic and/or progressive prostate cancer in palliative setting. Mestranol A synthetic estradiol found in oral contraceptive pills for contraception and the treatment of other conditions in the female reproductive system, such as dysmenorrhea and dysfunctional uterine bleeding. Equilin For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and... EM-1745 Not Available 2-Methoxyestradiol For the treatment of breast cancer and inflammatory diseases such as rheumatoid arthritis. Equilenin Equilenin is an estrogenic steroid produced by horses. It has a total of five double bonds in the A- and B-ring. High concentration of equilenin is found in the urine... Estriol Used as a test to determine the general health of an unborn fetus. Estrone sulfate An estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders. Quinestrol Used in hormone replacement therapy, treating symptoms of menopause such as hot flashes. Also used to treat breast and prostate cancer. Oleoyl-estrone For the treatment of obesity. 2-Hydroxyestradiol 2-Hydroxyestradiol is classified as an endogenous steroid, catechol estrogen, and metabolite of estradiol. It is also a positional isomer of estriol. Polyestradiol phosphate Polymeric phosphoric acid ester of estradiol. Estetrol Estetrol has been investigated for the treatment and basic science of Prostatic Neoplasms. Promestriene Promestriene has been used in trials studying the prevention of Hypospadias. Oxabolone cipionate Used as a performance enhancing drug illicitly in athletes. Moxestrol Not Annotated Estradiol benzoate Estradiol benzoate is not currently available in any FDA or Health Canada approved products. Estradiol cypionate An estradiol prodrug used to treat vasomotor symptoms and hypoestrogenisms from hypogonadism. Estradiol dienanthate Estradiol dienanthate is not currently available in any FDA or Health Canada approved products. Estradiol valerate An estradiol prodrug used to treat some effects of menopause, hypoestrogenism, androgen dependant carcinoma of the prostate, and in combination products for endometriosis and contraception. Estradiol sulfamate Investigated for use/treatment in endometriosis. ICI-164384 Not Available Fluoroestradiol F-18 A radiolabeled analog of estradiol used as a contrast agent in the PET imaging of estrogen receptor-positive breast cancer lesions.
- Drugs & Drug Targets