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IdentificationPharmacologyInteractionsReferencesTrialsEconomicsPropertiesSpectraTaxonomyEstrogens, esterified
Identification
- Name
- Estrogens, esterified
- Accession Number
- DB09381
- Type
- Small Molecule
- Groups
- Approved
- Description
Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of menopause such as hot flashes, vaginal dryness, vaginal burning or irritation, or other hormonal changes in the vagina. It is being also for the prevention and treatment of osteoporosis.
- Synonyms
- Esterified Estrogens
- Estrogens, Esterified Component of Menrium
- Estrogens,esterified
- Menrium Component Estrogens, Esterified
- Product Images
- Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Estragyn Tablet 0.3 mg Oral Searchlight Pharma Inc 1980-12-31 Not applicable Canada 
Estragyn Tablet 0.625 mg Oral Searchlight Pharma Inc 1974-12-31 Not applicable Canada Neo Estrone Tab 1.25mg Tablet 1.25 mg Oral Neolab Inc 1974-12-31 2008-04-02 Canada - Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Menest Tablet .625 mg/1 Oral Physicians Total Care, Inc. 2008-09-05 Not applicable US 
Menest Tablet, film coated .3 mg/1 Oral Pfizer Laboratories Div Pfizer Inc. 1977-09-28 Not applicable US Menest Tablet 1.25 mg/1 Oral Physicians Total Care, Inc. 2010-12-16 Not applicable US Menest Tablet, film coated 1.25 mg/1 Oral Pfizer Laboratories Div Pfizer Inc. 1977-09-28 Not applicable US Menest Tablet, film coated 2.5 mg/1 Oral Pfizer Laboratories Div Pfizer Inc. 1977-09-28 2017-10-18 US Menest Tablet .3 mg/1 Oral Physicians Total Care, Inc. 2010-12-09 Not applicable US Menest Tablet, film coated .625 mg/1 Oral Pfizer Laboratories Div Pfizer Inc. 1977-09-28 Not applicable US Menest Tablet, film coated .625 mg/1 Oral Avera Mc Kennan Hospital 2015-11-23 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Covaryx Estrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1) Tablet, coated Oral Centrix Pharmaceutical 2007-04-01 Not applicable US 
Covaryx Hs Estrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1) Tablet, coated Oral Centrix Pharmaceutical 2007-04-01 Not applicable US Eemt Estrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1) Tablet, coated Oral Creekwood Pharmaceuticals, Inc. 2011-09-01 Not applicable US Eemt Hs Estrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1) Tablet, coated Oral Creekwood Pharmaceuticals, Inc. 2011-09-01 Not applicable US Esterified Estrogens and Methyltestosterone Estrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1) Tablet Oral Method Pharmaceuticals 2017-08-15 Not applicable US Esterified Estrogens and Methyltestosterone Estrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1) Tablet Oral ANI Pharmaceuticals, Inc. 2010-12-22 Not applicable US Esterified Estrogens and Methyltestosterone Estrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1) Tablet Oral Method Pharmaceuticals 2017-08-15 Not applicable US Esterified Estrogens and Methyltestosterone Estrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1) Tablet Oral ANI Pharmaceuticals, Inc. 2010-12-22 Not applicable US - International/Other Brands
- Amnestrogen / Estratab / Evex / Femogen
- Categories
- UNII
- 3ASP8Q3768
- CAS number
- Not Available
- Weight
- Not Available
- Chemical Formula
- Not Available
- InChI Key
- Not Available
- InChI
- Not Available
- IUPAC Name
- Not Available
- SMILES
- Not Available
Pharmacology
- Indication
Esterified estrogens are indicated to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. It is also indicated for the treatment of symptoms of breast cancer in both men and women. In men it can be used for the treatment of advanced prostate cancer. It is also indicated for the treatment of menopausal symptoms.
- Structured Indications
- Pharmacodynamics
Estrogens are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Estradiol is the principle intracellular human estrogen and is more potent than estrone and estriol at the receptor level; it is the primary estrogen secreted prior to menopause.
- Mechanism of action
Estrogens modulate the pituitary secretion of gonadotropins, luteinizing hormone, and follicle-stimulating hormone through a negative feedback system; estrogen replacement reduces elevated levels of these hormones.
- Absorption
Readily absorbed after oral administration. High concentrations of estrone are achieved with oral administration, whereas higher concentrations of estradiol are generally achieved after percutaneous absorption. Although vaginal products (such as gel, rings, etc.) are administered locally, they achieve high serum concentrations.
- Volume of distribution
The distribution of exogenous estrogens is similar to that of endogenous estrogens. Estrogens are widely distributed in the body and are generally found in higher concentration in the sex hormone target organs.
- Protein binding
Approximately 95-98% of estradiol is bound loosely to albumin or tightly to sex hormone binding globulin.
- Metabolism
Hepatic; partial metabolism via CYP3A4 enzymes; estradiol is reversibly converted to estrone and estriol; oral estradiol also undergoes enterohepatic recirculation by conjugation in the liver, followed by excretion of sulfate and glucuronide conjugates into the bile, then hydrolysis in the intestine and estrogen reabsorption. Sulfate conjugates are the primary form found in postmenopausal women.
- Route of elimination
Mainly urinary as estradiol, estrone, estriol, and their glucuronide and sulfate conjugates.
- Half life
Half-life varies, it is in the range 1-2 hr.
- Clearance
There is variation in the clearance rate depends on each estrogen individual: estradiol-17β: 580 L/day/m2 estrone: 4050 L/day/m2 estriol: 1110 L/day/m2
- Toxicity
LD50 IP 325 mg/Kg (rat). LD50 IV 1740 mg/Kg (mouse). LD50 oral >5000 mg/Kg (rat).
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
Drug Interaction Drug group 1,10-Phenanthroline The serum concentration of Estrogens, esterified can be decreased when it is combined with 1,10-Phenanthroline. Experimental 16-Bromoepiandrosterone The serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Estrogens, esterified. Investigational 19-norandrostenedione The serum concentration of 19-norandrostenedione can be increased when it is combined with Estrogens, esterified. Experimental, Illicit 3,4-Dichloroisocoumarin The serum concentration of Estrogens, esterified can be decreased when it is combined with 3,4-Dichloroisocoumarin. Experimental 4-(2-Aminoethyl)Benzenesulfonyl Fluoride The serum concentration of Estrogens, esterified can be decreased when it is combined with 4-(2-Aminoethyl)Benzenesulfonyl Fluoride. Experimental 5-androstenedione The serum concentration of 5-androstenedione can be increased when it is combined with Estrogens, esterified. Experimental, Illicit Abciximab Estrogens, esterified may decrease the anticoagulant activities of Abciximab. Approved Acenocoumarol Estrogens, esterified may decrease the anticoagulant activities of Acenocoumarol. Approved, Investigational Acitretin The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Acitretin. Approved Adapalene The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Adapalene. Approved Alclometasone The serum concentration of Alclometasone can be increased when it is combined with Estrogens, esterified. Approved Aldosterone The serum concentration of Aldosterone can be increased when it is combined with Estrogens, esterified. Experimental, Investigational Alitretinoin The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Alitretinoin. Approved, Investigational Alogliptin The serum concentration of Estrogens, esterified can be decreased when it is combined with Alogliptin. Approved Alpha-1-proteinase inhibitor The serum concentration of Estrogens, esterified can be decreased when it is combined with Alpha-1-proteinase inhibitor. Approved Ambroxol acefyllinate The serum concentration of Ambroxol acefyllinate can be increased when it is combined with Estrogens, esterified. Experimental, Investigational Amcinonide The serum concentration of Amcinonide can be increased when it is combined with Estrogens, esterified. Approved Aminophylline The serum concentration of Aminophylline can be increased when it is combined with Estrogens, esterified. Approved Amiodarone The metabolism of Estrogens, esterified can be decreased when combined with Amiodarone. Approved, Investigational Amobarbital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Amobarbital. Approved, Illicit Amprenavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Amprenavir. Approved, Investigational Anastrozole The therapeutic efficacy of Anastrozole can be decreased when used in combination with Estrogens, esterified. Approved, Investigational Ancrod Estrogens, esterified may decrease the anticoagulant activities of Ancrod. Approved, Investigational Androstenedione The serum concentration of Androstenedione can be increased when it is combined with Estrogens, esterified. Experimental, Illicit Anecortave The serum concentration of Anecortave can be increased when it is combined with Estrogens, esterified. Investigational anecortave acetate The serum concentration of anecortave acetate can be increased when it is combined with Estrogens, esterified. Investigational Anthrax immune globulin human Estrogens, esterified may increase the thrombogenic activities of Anthrax immune globulin human. Approved Antithrombin III human The serum concentration of Estrogens, esterified can be decreased when it is combined with Antithrombin III human. Approved Apalutamide The serum concentration of Estrogens, esterified can be decreased when it is combined with Apalutamide. Approved, Investigational Apixaban The serum concentration of Estrogens, esterified can be decreased when it is combined with Apixaban. Approved Aprepitant The serum concentration of Estrogens, esterified can be decreased when it is combined with Aprepitant. Approved, Investigational Aprotinin The serum concentration of Estrogens, esterified can be decreased when it is combined with Aprotinin. Approved, Investigational, Withdrawn Ardeparin Estrogens, esterified may decrease the anticoagulant activities of Ardeparin. Approved, Investigational, Withdrawn Argatroban The serum concentration of Estrogens, esterified can be decreased when it is combined with Argatroban. Approved, Investigational Armodafinil The serum concentration of Estrogens, esterified can be decreased when it is combined with Armodafinil. Approved, Investigational Artemether The serum concentration of Estrogens, esterified can be decreased when it is combined with Artemether. Approved Asunaprevir The serum concentration of Estrogens, esterified can be decreased when it is combined with Asunaprevir. Approved, Investigational, Withdrawn Atamestane The serum concentration of Atamestane can be increased when it is combined with Estrogens, esterified. Investigational Atazanavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Atazanavir. Approved, Investigational Atomoxetine The metabolism of Estrogens, esterified can be decreased when combined with Atomoxetine. Approved Barbexaclone The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Barbexaclone. Experimental Barbital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Barbital. Illicit Batimastat The serum concentration of Estrogens, esterified can be decreased when it is combined with Batimastat. Experimental Becaplermin Estrogens, esterified may decrease the anticoagulant activities of Becaplermin. Approved, Investigational Beclomethasone dipropionate The serum concentration of Beclomethasone dipropionate can be increased when it is combined with Estrogens, esterified. Approved, Investigational Benazepril The serum concentration of Estrogens, esterified can be decreased when it is combined with Benazepril. Approved, Investigational Benzamidine The serum concentration of Estrogens, esterified can be decreased when it is combined with Benzamidine. Experimental Betamethasone The serum concentration of Betamethasone can be increased when it is combined with Estrogens, esterified. Approved, Vet Approved Bexarotene The serum concentration of Estrogens, esterified can be decreased when it is combined with Bexarotene. Approved, Investigational Bivalirudin The serum concentration of Estrogens, esterified can be decreased when it is combined with Bivalirudin. Approved, Investigational Boceprevir The serum concentration of Estrogens, esterified can be decreased when it is combined with Boceprevir. Approved, Withdrawn Bortezomib The metabolism of Estrogens, esterified can be decreased when combined with Bortezomib. Approved, Investigational Bosentan The serum concentration of Estrogens, esterified can be decreased when it is combined with Bosentan. Approved, Investigational Budesonide The serum concentration of Budesonide can be increased when it is combined with Estrogens, esterified. Approved Camostat The serum concentration of Estrogens, esterified can be decreased when it is combined with Camostat. Experimental Candoxatril The serum concentration of Estrogens, esterified can be decreased when it is combined with Candoxatril. Experimental Candoxatrilat The serum concentration of Estrogens, esterified can be decreased when it is combined with Candoxatrilat. Experimental Capromab pendetide Estrogens, esterified may decrease effectiveness of Capromab pendetide as a diagnostic agent. Approved Captopril The serum concentration of Estrogens, esterified can be decreased when it is combined with Captopril. Approved Carbamazepine The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Carbamazepine. Approved, Investigational Celecoxib Celecoxib may increase the thrombogenic activities of Estrogens, esterified. Approved, Investigational Ceritinib The serum concentration of Estrogens, esterified can be increased when it is combined with Ceritinib. Approved Certoparin Estrogens, esterified may decrease the anticoagulant activities of Certoparin. Approved, Investigational Chenodeoxycholic acid The therapeutic efficacy of Chenodeoxycholic acid can be decreased when used in combination with Estrogens, esterified. Approved Cholesterol The serum concentration of Estrogens, esterified can be decreased when it is combined with Cholesterol. Approved, Experimental, Investigational Cholestyramine The serum concentration of Estrogens, esterified can be decreased when it is combined with Cholestyramine. Approved, Investigational Chymostatin The serum concentration of Estrogens, esterified can be decreased when it is combined with Chymostatin. Experimental Ciclesonide The serum concentration of Ciclesonide can be increased when it is combined with Estrogens, esterified. Approved, Investigational Cilastatin The serum concentration of Estrogens, esterified can be decreased when it is combined with Cilastatin. Approved, Investigational Cilazapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Cilazapril. Approved Citric Acid Estrogens, esterified may decrease the anticoagulant activities of Citric Acid. Approved, Nutraceutical, Vet Approved Clarithromycin The metabolism of Estrogens, esterified can be decreased when combined with Clarithromycin. Approved Clemastine The metabolism of Estrogens, esterified can be decreased when combined with Clemastine. Approved, Investigational Clobazam The serum concentration of Estrogens, esterified can be decreased when it is combined with Clobazam. Approved, Illicit Clobetasol The serum concentration of Clobetasol can be increased when it is combined with Estrogens, esterified. Approved, Investigational Clobetasol propionate The serum concentration of Clobetasol propionate can be increased when it is combined with Estrogens, esterified. Approved Clobetasone The serum concentration of Clobetasone can be increased when it is combined with Estrogens, esterified. Approved Clocortolone The serum concentration of Clocortolone can be increased when it is combined with Estrogens, esterified. Approved Clorindione Estrogens, esterified may decrease the anticoagulant activities of Clorindione. Experimental Clotrimazole The metabolism of Estrogens, esterified can be decreased when combined with Clotrimazole. Approved, Vet Approved Cobicistat The serum concentration of Estrogens, esterified can be decreased when it is combined with Cobicistat. Approved Colesevelam The serum concentration of Estrogens, esterified can be decreased when it is combined with Colesevelam. Approved Colestipol The serum concentration of Estrogens, esterified can be decreased when it is combined with Colestipol. Approved Conestat alfa Estrogens, esterified may increase the thrombogenic activities of Conestat alfa. Approved, Investigational Conivaptan The serum concentration of Conivaptan can be increased when it is combined with Estrogens, esterified. Approved, Investigational Cortexolone 17α-propionate The serum concentration of Cortexolone 17α-propionate can be increased when it is combined with Estrogens, esterified. Investigational Corticosterone The serum concentration of Corticosterone can be increased when it is combined with Estrogens, esterified. Experimental Cortisone acetate The serum concentration of Cortisone acetate can be increased when it is combined with Estrogens, esterified. Approved, Investigational Crizotinib The metabolism of Estrogens, esterified can be decreased when combined with Crizotinib. Approved Cyclosporine The metabolism of Estrogens, esterified can be decreased when combined with Cyclosporine. Approved, Investigational, Vet Approved Dabigatran etexilate The serum concentration of Estrogens, esterified can be decreased when it is combined with Dabigatran etexilate. Approved Dabrafenib The serum concentration of Estrogens, esterified can be decreased when it is combined with Dabrafenib. Approved, Investigational Dalteparin Estrogens, esterified may decrease the anticoagulant activities of Dalteparin. Approved Danaparoid Estrogens, esterified may decrease the anticoagulant activities of Danaparoid. Approved, Withdrawn Darexaban The serum concentration of Estrogens, esterified can be decreased when it is combined with Darexaban. Investigational Darunavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Darunavir. Approved Dasatinib The serum concentration of Estrogens, esterified can be increased when it is combined with Dasatinib. Approved, Investigational Deferasirox The serum concentration of Estrogens, esterified can be decreased when it is combined with Deferasirox. Approved, Investigational Deflazacort The serum concentration of Deflazacort can be increased when it is combined with Estrogens, esterified. Approved, Investigational Delanzomib The serum concentration of Estrogens, esterified can be decreased when it is combined with Delanzomib. Investigational Delapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Delapril. Experimental Delavirdine The metabolism of Estrogens, esterified can be decreased when combined with Delavirdine. Approved Desirudin Estrogens, esterified may decrease the anticoagulant activities of Desirudin. Approved Desonide The serum concentration of Desonide can be increased when it is combined with Estrogens, esterified. Approved, Investigational Desoximetasone The serum concentration of Desoximetasone can be increased when it is combined with Estrogens, esterified. Approved Desoxycorticosterone acetate The serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Estrogens, esterified. Approved Desoxycorticosterone Pivalate The serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Estrogens, esterified. Experimental, Vet Approved Dexamethasone The serum concentration of Dexamethasone can be increased when it is combined with Estrogens, esterified. Approved, Investigational, Vet Approved Dexamethasone isonicotinate The serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Estrogens, esterified. Vet Approved Dextran Estrogens, esterified may decrease the anticoagulant activities of Dextran. Approved, Investigational, Vet Approved Dicoumarol Estrogens, esterified may decrease the anticoagulant activities of Dicoumarol. Approved Diflorasone The serum concentration of Diflorasone can be increased when it is combined with Estrogens, esterified. Approved Difluocortolone The serum concentration of Difluocortolone can be increased when it is combined with Estrogens, esterified. Approved, Investigational, Withdrawn Difluprednate The serum concentration of Difluprednate can be increased when it is combined with Estrogens, esterified. Approved Dihydroergotamine The metabolism of Estrogens, esterified can be decreased when combined with Dihydroergotamine. Approved, Investigational Diltiazem The metabolism of Estrogens, esterified can be decreased when combined with Diltiazem. Approved, Investigational Diphenadione Estrogens, esterified may decrease the anticoagulant activities of Diphenadione. Experimental Doxycycline The metabolism of Estrogens, esterified can be decreased when combined with Doxycycline. Approved, Investigational, Vet Approved Dronedarone The metabolism of Estrogens, esterified can be decreased when combined with Dronedarone. Approved Dyphylline The serum concentration of Dyphylline can be increased when it is combined with Estrogens, esterified. Approved Ecabet The serum concentration of Estrogens, esterified can be decreased when it is combined with Ecabet. Approved, Investigational Edetic Acid Estrogens, esterified may decrease the anticoagulant activities of Edetic Acid. Approved, Vet Approved Edoxaban The serum concentration of Estrogens, esterified can be decreased when it is combined with Edoxaban. Approved Elafin The serum concentration of Estrogens, esterified can be decreased when it is combined with Elafin. Investigational Elvitegravir The serum concentration of Estrogens, esterified can be decreased when it is combined with Elvitegravir. Approved Enalapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Enalapril. Approved, Vet Approved Enalaprilat The serum concentration of Estrogens, esterified can be decreased when it is combined with Enalaprilat. Approved Enalkiren The serum concentration of Estrogens, esterified can be decreased when it is combined with Enalkiren. Experimental Enoxaparin Estrogens, esterified may decrease the anticoagulant activities of Enoxaparin. Approved Enzalutamide The serum concentration of Estrogens, esterified can be decreased when it is combined with Enzalutamide. Approved Epigallocatechin Gallate The serum concentration of Estrogens, esterified can be decreased when it is combined with Epigallocatechin Gallate. Investigational Equilenin The serum concentration of Equilenin can be increased when it is combined with Estrogens, esterified. Experimental Equilin The serum concentration of Equilin can be increased when it is combined with Estrogens, esterified. Approved Erythromycin The metabolism of Estrogens, esterified can be decreased when combined with Erythromycin. Approved, Investigational, Vet Approved Eslicarbazepine acetate The serum concentration of Estrogens, esterified can be decreased when it is combined with Eslicarbazepine acetate. Approved Estrone The serum concentration of Estrone can be increased when it is combined with Estrogens, esterified. Approved Estrone sulfate The serum concentration of Estrone sulfate can be increased when it is combined with Estrogens, esterified. Approved Ethyl biscoumacetate Estrogens, esterified may decrease the anticoagulant activities of Ethyl biscoumacetate. Withdrawn Etodolac Etodolac may increase the thrombogenic activities of Estrogens, esterified. Approved, Investigational, Vet Approved Etoricoxib Etoricoxib may increase the thrombogenic activities of Estrogens, esterified. Approved, Investigational Exemestane The therapeutic efficacy of Exemestane can be decreased when used in combination with Estrogens, esterified. Approved, Investigational Exenatide The serum concentration of Estrogens, esterified can be decreased when it is combined with Exenatide. Approved, Investigational Faldaprevir The serum concentration of Estrogens, esterified can be decreased when it is combined with Faldaprevir. Investigational Felbamate The serum concentration of Estrogens, esterified can be decreased when it is combined with Felbamate. Approved Ferulic acid Estrogens, esterified may decrease the anticoagulant activities of Ferulic acid. Experimental Flibanserin The serum concentration of Flibanserin can be increased when it is combined with Estrogens, esterified. Approved, Investigational Fluasterone The serum concentration of Fluasterone can be increased when it is combined with Estrogens, esterified. Investigational Fluconazole The metabolism of Estrogens, esterified can be decreased when combined with Fluconazole. Approved, Investigational Fludrocortisone The serum concentration of Fludrocortisone can be increased when it is combined with Estrogens, esterified. Approved, Investigational Fluindione Estrogens, esterified may decrease the anticoagulant activities of Fluindione. Approved, Investigational Flumethasone The serum concentration of Flumethasone can be increased when it is combined with Estrogens, esterified. Approved, Vet Approved Flunisolide The serum concentration of Flunisolide can be increased when it is combined with Estrogens, esterified. Approved, Investigational Fluocinolone Acetonide The serum concentration of Fluocinolone Acetonide can be increased when it is combined with Estrogens, esterified. Approved, Investigational, Vet Approved Fluocinonide The serum concentration of Fluocinonide can be increased when it is combined with Estrogens, esterified. Approved, Investigational Fluocortolone The serum concentration of Fluocortolone can be increased when it is combined with Estrogens, esterified. Approved, Withdrawn Fluorometholone The serum concentration of Fluorometholone can be increased when it is combined with Estrogens, esterified. Approved, Investigational Fluprednidene The serum concentration of Fluprednidene can be increased when it is combined with Estrogens, esterified. Approved, Withdrawn Fluprednisolone The serum concentration of Fluprednisolone can be increased when it is combined with Estrogens, esterified. Approved Flurandrenolide The serum concentration of Flurandrenolide can be increased when it is combined with Estrogens, esterified. Approved Fluticasone furoate The serum concentration of Fluticasone furoate can be increased when it is combined with Estrogens, esterified. Approved Fluticasone propionate The serum concentration of Fluticasone propionate can be increased when it is combined with Estrogens, esterified. Approved Fluvoxamine The metabolism of Estrogens, esterified can be decreased when combined with Fluvoxamine. Approved, Investigational Fondaparinux Estrogens, esterified may decrease the anticoagulant activities of Fondaparinux. Approved, Investigational Fondaparinux sodium Estrogens, esterified may decrease the anticoagulant activities of Fondaparinux sodium. Approved, Investigational Formestane The serum concentration of Formestane can be increased when it is combined with Estrogens, esterified. Approved, Investigational, Withdrawn Fosamprenavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Fosamprenavir. Approved Fosaprepitant The serum concentration of Estrogens, esterified can be decreased when it is combined with Fosaprepitant. Approved Fosinopril The serum concentration of Estrogens, esterified can be decreased when it is combined with Fosinopril. Approved Fosphenytoin The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Fosphenytoin. Approved, Investigational Fusidic Acid The serum concentration of Estrogens, esterified can be increased when it is combined with Fusidic Acid. Approved, Investigational Gabexate The serum concentration of Estrogens, esterified can be decreased when it is combined with Gabexate. Investigational Geldanamycin The serum concentration of Estrogens, esterified can be decreased when it is combined with Geldanamycin. Experimental, Investigational GM6001 The serum concentration of Estrogens, esterified can be decreased when it is combined with GM6001. Experimental Griseofulvin The metabolism of Estrogens, esterified can be increased when combined with Griseofulvin. Approved, Investigational, Vet Approved Halcinonide The serum concentration of Halcinonide can be increased when it is combined with Estrogens, esterified. Approved, Investigational, Withdrawn HE3286 The serum concentration of HE3286 can be increased when it is combined with Estrogens, esterified. Investigational Heparin Estrogens, esterified may decrease the anticoagulant activities of Heparin. Approved, Investigational Hexobarbital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Hexobarbital. Approved Human C1-esterase inhibitor Estrogens, esterified may increase the thrombogenic activities of Human C1-esterase inhibitor. Approved Hyaluronidase The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Estrogens, esterified. Approved, Investigational Hydrocortisone The serum concentration of Hydrocortisone can be increased when it is combined with Estrogens, esterified. Approved, Vet Approved Idelalisib The metabolism of Estrogens, esterified can be decreased when combined with Idelalisib. Approved Idraparinux The serum concentration of Estrogens, esterified can be decreased when it is combined with Idraparinux. Investigational Imatinib The metabolism of Estrogens, esterified can be decreased when combined with Imatinib. Approved Imidapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Imidapril. Investigational Indinavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Indinavir. Approved Isavuconazole The serum concentration of Estrogens, esterified can be increased when it is combined with Isavuconazole. Approved, Investigational Isavuconazonium The metabolism of Estrogens, esterified can be decreased when combined with Isavuconazonium. Approved, Investigational Isoflurophate The serum concentration of Estrogens, esterified can be decreased when it is combined with Isoflurophate. Approved, Investigational, Withdrawn Isotretinoin The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Isotretinoin. Approved Isradipine The metabolism of Estrogens, esterified can be decreased when combined with Isradipine. Approved, Investigational Istaroxime The serum concentration of Istaroxime can be increased when it is combined with Estrogens, esterified. Investigational Itraconazole The metabolism of Estrogens, esterified can be decreased when combined with Itraconazole. Approved, Investigational Ivacaftor The serum concentration of Estrogens, esterified can be increased when it is combined with Ivacaftor. Approved Ixazomib The serum concentration of Estrogens, esterified can be decreased when it is combined with Ixazomib. Approved, Investigational Ketoconazole The metabolism of Estrogens, esterified can be decreased when combined with Ketoconazole. Approved, Investigational Lamotrigine The serum concentration of Lamotrigine can be decreased when it is combined with Estrogens, esterified. Approved, Investigational Lenalidomide Estrogens, esterified may increase the thrombogenic activities of Lenalidomide. Approved Lepirudin The serum concentration of Estrogens, esterified can be decreased when it is combined with Lepirudin. Approved Letaxaban The serum concentration of Estrogens, esterified can be decreased when it is combined with Letaxaban. Investigational Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Estrogens, esterified. Approved Linagliptin The serum concentration of Estrogens, esterified can be decreased when it is combined with Linagliptin. Approved Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Estrogens, esterified. Approved, Vet Approved Liotrix The therapeutic efficacy of Liotrix can be decreased when used in combination with Estrogens, esterified. Approved Lisinopril The serum concentration of Estrogens, esterified can be decreased when it is combined with Lisinopril. Approved, Investigational Lopinavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Lopinavir. Approved Lorpiprazole The serum concentration of Estrogens, esterified can be increased when it is combined with Lorpiprazole. Approved Loteprednol The serum concentration of Loteprednol can be increased when it is combined with Estrogens, esterified. Approved Lovastatin The metabolism of Estrogens, esterified can be decreased when combined with Lovastatin. Approved, Investigational Luliconazole The serum concentration of Estrogens, esterified can be increased when it is combined with Luliconazole. Approved Lumacaftor The serum concentration of Estrogens, esterified can be decreased when it is combined with Lumacaftor. Approved Lumiracoxib Lumiracoxib may increase the thrombogenic activities of Estrogens, esterified. Approved, Investigational ME-609 The serum concentration of ME-609 can be increased when it is combined with Estrogens, esterified. Investigational Medrysone The serum concentration of Medrysone can be increased when it is combined with Estrogens, esterified. Approved Melagatran The serum concentration of Estrogens, esterified can be decreased when it is combined with Melagatran. Experimental Melengestrol The serum concentration of Melengestrol can be increased when it is combined with Estrogens, esterified. Vet Approved Methohexital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Methohexital. Approved Methylphenobarbital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Methylphenobarbital. Approved Methylprednisolone The serum concentration of Methylprednisolone can be increased when it is combined with Estrogens, esterified. Approved, Vet Approved Metreleptin The serum concentration of Estrogens, esterified can be decreased when it is combined with Metreleptin. Approved Mifepristone The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Mifepristone. Approved, Investigational Mitotane The serum concentration of Estrogens, esterified can be decreased when it is combined with Mitotane. Approved Modafinil The serum concentration of Estrogens, esterified can be decreased when it is combined with Modafinil. Approved, Investigational Moexipril The serum concentration of Estrogens, esterified can be decreased when it is combined with Moexipril. Approved Mometasone The serum concentration of Mometasone can be increased when it is combined with Estrogens, esterified. Approved, Vet Approved Mycophenolic acid The serum concentration of Estrogens, esterified can be decreased when it is combined with Mycophenolic acid. Approved N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline The serum concentration of Estrogens, esterified can be decreased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline. Experimental Nabumetone Nabumetone may increase the thrombogenic activities of Estrogens, esterified. Approved Nadroparin Estrogens, esterified may decrease the anticoagulant activities of Nadroparin. Approved, Investigational Nafamostat The serum concentration of Estrogens, esterified can be decreased when it is combined with Nafamostat. Approved, Investigational Nafcillin The metabolism of Estrogens, esterified can be increased when combined with Nafcillin. Approved, Investigational NCX 1022 The serum concentration of NCX 1022 can be increased when it is combined with Estrogens, esterified. Investigational Nefazodone The metabolism of Estrogens, esterified can be decreased when combined with Nefazodone. Approved, Withdrawn Nelfinavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Nelfinavir. Approved Netupitant The serum concentration of Estrogens, esterified can be increased when it is combined with Netupitant. Approved, Investigational Nevirapine The serum concentration of Estrogens, esterified can be decreased when it is combined with Nevirapine. Approved Nilotinib The metabolism of Estrogens, esterified can be decreased when combined with Nilotinib. Approved, Investigational Nitroaspirin The serum concentration of Estrogens, esterified can be decreased when it is combined with Nitroaspirin. Investigational Olaparib The metabolism of Estrogens, esterified can be decreased when combined with Olaparib. Approved Oleoyl-estrone The serum concentration of Oleoyl-estrone can be increased when it is combined with Estrogens, esterified. Investigational Omapatrilat The serum concentration of Estrogens, esterified can be decreased when it is combined with Omapatrilat. Investigational Osimertinib The serum concentration of Estrogens, esterified can be increased when it is combined with Osimertinib. Approved Ospemifene The risk or severity of adverse effects can be increased when Estrogens, esterified is combined with Ospemifene. Approved, Investigational Otamixaban The serum concentration of Estrogens, esterified can be decreased when it is combined with Otamixaban. Investigational Oxcarbazepine The serum concentration of Estrogens, esterified can be decreased when it is combined with Oxcarbazepine. Approved Palbociclib The serum concentration of Estrogens, esterified can be increased when it is combined with Palbociclib. Approved, Investigational Paramethasone The serum concentration of Paramethasone can be increased when it is combined with Estrogens, esterified. Approved Parecoxib Parecoxib may increase the thrombogenic activities of Estrogens, esterified. Approved Pentaerythritol Tetranitrate Estrogens, esterified may decrease the anticoagulant activities of Pentaerythritol Tetranitrate. Approved Pentobarbital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Pentobarbital. Approved, Investigational, Vet Approved Pentosan Polysulfate Estrogens, esterified may decrease the anticoagulant activities of Pentosan Polysulfate. Approved Perindopril The serum concentration of Estrogens, esterified can be decreased when it is combined with Perindopril. Approved Phenindione Estrogens, esterified may decrease the anticoagulant activities of Phenindione. Approved, Investigational Phenobarbital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Phenobarbital. Approved, Investigational Phenprocoumon Estrogens, esterified may decrease the anticoagulant activities of Phenprocoumon. Approved, Investigational Phenytoin The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Phenytoin. Approved, Vet Approved Phosphoramidon The serum concentration of Estrogens, esterified can be decreased when it is combined with Phosphoramidon. Experimental Pitolisant The serum concentration of Estrogens, esterified can be decreased when it is combined with Pitolisant. Approved, Investigational Posaconazole The metabolism of Estrogens, esterified can be decreased when combined with Posaconazole. Approved, Investigational, Vet Approved Prasterone The risk or severity of adverse effects can be increased when Prasterone is combined with Estrogens, esterified. Approved, Investigational, Nutraceutical Prasterone sulfate The serum concentration of Prasterone sulfate can be increased when it is combined with Estrogens, esterified. Investigational Prednicarbate The serum concentration of Prednicarbate can be increased when it is combined with Estrogens, esterified. Approved, Investigational Prednisolone The serum concentration of Prednisolone can be increased when it is combined with Estrogens, esterified. Approved, Vet Approved Prednisone The serum concentration of Prednisone can be increased when it is combined with Estrogens, esterified. Approved, Vet Approved Pregnenolone The serum concentration of Pregnenolone can be increased when it is combined with Estrogens, esterified. Approved, Experimental, Investigational Primidone The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Primidone. Approved, Vet Approved Prinomastat The serum concentration of Estrogens, esterified can be decreased when it is combined with Prinomastat. Investigational Protein C Estrogens, esterified may decrease the anticoagulant activities of Protein C. Approved Protein S human Estrogens, esterified may decrease the anticoagulant activities of Protein S human. Approved Protocatechualdehyde Estrogens, esterified may decrease the anticoagulant activities of Protocatechualdehyde. Approved Prucalopride The serum concentration of Estrogens, esterified can be decreased when it is combined with Prucalopride. Approved Quinapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Quinapril. Approved, Investigational Racecadotril The serum concentration of Estrogens, esterified can be decreased when it is combined with Racecadotril. Investigational Ramipril The serum concentration of Estrogens, esterified can be decreased when it is combined with Ramipril. Approved Ranolazine The metabolism of Estrogens, esterified can be decreased when combined with Ranolazine. Approved, Investigational Remikiren The serum concentration of Estrogens, esterified can be decreased when it is combined with Remikiren. Approved Reviparin Estrogens, esterified may decrease the anticoagulant activities of Reviparin. Approved, Investigational Rifabutin The serum concentration of Estrogens, esterified can be decreased when it is combined with Rifabutin. Approved, Investigational Rifampicin The serum concentration of Estrogens, esterified can be decreased when it is combined with Rifampicin. Approved Rifapentine The serum concentration of Estrogens, esterified can be decreased when it is combined with Rifapentine. Approved, Investigational Rifaximin The serum concentration of Estrogens, esterified can be decreased when it is combined with Rifaximin. Approved, Investigational Rimexolone The serum concentration of Rimexolone can be increased when it is combined with Estrogens, esterified. Approved Ritonavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Ritonavir. Approved, Investigational Rivaroxaban The serum concentration of Estrogens, esterified can be decreased when it is combined with Rivaroxaban. Approved Rofecoxib Rofecoxib may increase the thrombogenic activities of Estrogens, esterified. Approved, Investigational, Withdrawn Ropinirole The serum concentration of Ropinirole can be increased when it is combined with Estrogens, esterified. Approved, Investigational Rucaparib The metabolism of Estrogens, esterified can be decreased when combined with Rucaparib. Approved, Investigational S-3304 The serum concentration of Estrogens, esterified can be decreased when it is combined with S-3304. Investigational Saquinavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Saquinavir. Approved, Investigational Sarilumab The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Sarilumab. Approved, Investigational Saxagliptin The serum concentration of Estrogens, esterified can be decreased when it is combined with Saxagliptin. Approved Secobarbital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Secobarbital. Approved, Vet Approved Selegiline The serum concentration of Selegiline can be increased when it is combined with Estrogens, esterified. Approved, Investigational, Vet Approved Sildenafil The metabolism of Estrogens, esterified can be decreased when combined with Sildenafil. Approved, Investigational Siltuximab The serum concentration of Estrogens, esterified can be decreased when it is combined with Siltuximab. Approved, Investigational Simeprevir The serum concentration of Estrogens, esterified can be increased when it is combined with Simeprevir. Approved Sitagliptin The serum concentration of Estrogens, esterified can be decreased when it is combined with Sitagliptin. Approved, Investigational Sivelestat The serum concentration of Estrogens, esterified can be decreased when it is combined with Sivelestat. Investigational Somatotropin The therapeutic efficacy of Somatotropin can be decreased when used in combination with Estrogens, esterified. Approved, Investigational Spirapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Spirapril. Approved St. John's Wort The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with St. John's Wort. Approved, Investigational, Nutraceutical Stiripentol The serum concentration of Estrogens, esterified can be increased when it is combined with Stiripentol. Approved Sulfisoxazole The metabolism of Estrogens, esterified can be decreased when combined with Sulfisoxazole. Approved, Vet Approved Sulodexide Estrogens, esterified may decrease the anticoagulant activities of Sulodexide. Approved, Investigational Telaprevir The serum concentration of Estrogens, esterified can be decreased when it is combined with Telaprevir. Approved, Withdrawn Telithromycin The metabolism of Estrogens, esterified can be decreased when combined with Telithromycin. Approved Temocapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Temocapril. Experimental, Investigational Thalidomide Estrogens, esterified may increase the thrombogenic activities of Thalidomide. Approved, Investigational, Withdrawn Theophylline The serum concentration of Theophylline can be increased when it is combined with Estrogens, esterified. Approved Thiamylal The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Thiamylal. Approved, Vet Approved Thiopental The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Thiopental. Approved, Vet Approved Thiorphan The serum concentration of Estrogens, esterified can be decreased when it is combined with Thiorphan. Experimental Thyroid, porcine The therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Estrogens, esterified. Approved Ticlopidine The metabolism of Estrogens, esterified can be decreased when combined with Ticlopidine. Approved Tioclomarol Estrogens, esterified may decrease the anticoagulant activities of Tioclomarol. Experimental Tipranavir Estrogens, esterified may increase the dermatologic adverse activities of Tipranavir. Approved, Investigational Tixocortol The serum concentration of Tixocortol can be increased when it is combined with Estrogens, esterified. Approved, Withdrawn Tocilizumab The serum concentration of Estrogens, esterified can be decreased when it is combined with Tocilizumab. Approved Topiramate The serum concentration of Estrogens, esterified can be decreased when it is combined with Topiramate. Approved Trandolapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Trandolapril. Approved Tranexamic Acid Estrogens, esterified may increase the thrombogenic activities of Tranexamic Acid. Approved Tretinoin The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Tretinoin. Approved, Investigational, Nutraceutical Triamcinolone The serum concentration of Triamcinolone can be increased when it is combined with Estrogens, esterified. Approved, Vet Approved Troxerutin Estrogens, esterified may decrease the anticoagulant activities of Troxerutin. Investigational Ubenimex The serum concentration of Estrogens, esterified can be decreased when it is combined with Ubenimex. Experimental, Investigational Ulinastatin The serum concentration of Estrogens, esterified can be decreased when it is combined with Ulinastatin. Investigational Ulobetasol The serum concentration of Ulobetasol can be increased when it is combined with Estrogens, esterified. Approved Ursodeoxycholic acid The therapeutic efficacy of Ursodeoxycholic acid can be decreased when used in combination with Estrogens, esterified. Approved, Investigational Valdecoxib Valdecoxib may increase the thrombogenic activities of Estrogens, esterified. Approved, Investigational, Withdrawn Vemurafenib The serum concentration of Estrogens, esterified can be decreased when it is combined with Vemurafenib. Approved Venlafaxine The metabolism of Estrogens, esterified can be decreased when combined with Venlafaxine. Approved Verapamil The metabolism of Estrogens, esterified can be decreased when combined with Verapamil. Approved Vildagliptin The serum concentration of Estrogens, esterified can be decreased when it is combined with Vildagliptin. Approved, Investigational Vitamin C The serum concentration of Estrogens, esterified can be increased when it is combined with Vitamin C. Approved, Nutraceutical Voriconazole The metabolism of Estrogens, esterified can be decreased when combined with Voriconazole. Approved, Investigational Warfarin Estrogens, esterified may decrease the anticoagulant activities of Warfarin. Approved Ximelagatran The serum concentration of Estrogens, esterified can be decreased when it is combined with Ximelagatran. Approved, Investigational, Withdrawn Z-Val-Ala-Asp fluoromethyl ketone The serum concentration of Estrogens, esterified can be decreased when it is combined with Z-Val-Ala-Asp fluoromethyl ketone. Experimental Ziprasidone The metabolism of Estrogens, esterified can be decreased when combined with Ziprasidone. Approved Zofenopril The serum concentration of Estrogens, esterified can be decreased when it is combined with Zofenopril. Experimental - Food Interactions
- Not Available
References
- General References
- External Links
- PubChem Substance
- 347910451
- Wikipedia
- Esterified_estrogens
- AHFS Codes
- 68:16.04 — Estrogens
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Hot Flushes, Menopause, Postmenopause 1 2 Completed Treatment Menopause 1 2 Terminated Treatment Cancer, Breast 1 2 Terminated Treatment Menopause 2
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage forms
Form Route Strength Tablet, coated Oral Tablet Oral Tablet Oral 0.3 mg Tablet Oral 0.625 mg Tablet Oral .3 mg/1 Tablet Oral .625 mg/1 Tablet Oral 1.25 mg/1 Tablet, film coated Oral .3 mg/1 Tablet, film coated Oral .625 mg/1 Tablet, film coated Oral 1.25 mg/1 Tablet, film coated Oral 2.5 mg/1 Tablet Oral 1.25 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
- Not Available
- Predicted ADMET features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Taxonomy
- Classification
- Not classified
Enzymes
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- CYP3A4
- Uniprot ID
- P08684
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
Drug created on November 30, 2015 12:10 / Updated on April 23, 2018 23:13