Estrogens, esterified

Identification

Name
Estrogens, esterified
Accession Number
DB09381
Type
Small Molecule
Groups
Approved
Description

Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of menopause such as hot flashes, vaginal dryness, vaginal burning or irritation, or other hormonal changes in the vagina. It is being also for the prevention and treatment of osteoporosis.

Synonyms
  • Esterified Estrogens
  • Estrogens, Esterified Component of Menrium
  • Estrogens,esterified
  • Menrium Component Estrogens, Esterified
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
EstragynTablet0.3 mgOralSearchlight Pharma Inc1980-12-31Not applicableCanada
EstragynTablet0.625 mgOralSearchlight Pharma Inc1974-12-31Not applicableCanada
Neo Estrone Tab 1.25mgTablet1.25 mgOralNeolab Inc1974-12-312008-04-02Canada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
MenestTablet1.25 mg/1OralPhysicians Total Care, Inc.2010-12-16Not applicableUs
MenestTablet, film coated.3 mg/1OralPfizer Laboratories Div Pfizer Inc.1977-09-28Not applicableUs
MenestTablet, film coated1.25 mg/1OralPfizer Laboratories Div Pfizer Inc.1977-09-28Not applicableUs
MenestTablet, film coated.625 mg/1OralAvera Mc Kennan Hospital2015-11-23Not applicableUs
MenestTablet.3 mg/1OralPhysicians Total Care, Inc.2010-12-09Not applicableUs
MenestTablet, film coated2.5 mg/1OralPfizer Laboratories Div Pfizer Inc.1977-09-282017-10-18Us
MenestTablet, film coated.625 mg/1OralPfizer Laboratories Div Pfizer Inc.1977-09-28Not applicableUs
MenestTablet.625 mg/1OralPhysicians Total Care, Inc.2008-09-05Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
CovaryxEstrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1)Tablet, coatedOralCentrix Pharmaceutical2007-04-01Not applicableUs11528 0010 01 nlmimage10 5905aced
Covaryx HsEstrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1)Tablet, coatedOralCentrix Pharmaceutical2007-04-01Not applicableUs
EemtEstrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1)Tablet, coatedOralCreekwood Pharmaceuticals, Inc.2011-09-01Not applicableUs
Eemt HsEstrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1)Tablet, coatedOralCreekwood Pharmaceuticals, Inc.2011-09-01Not applicableUs
Esterified Estrogens and MethyltestosteroneEstrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1)TabletOralMethod Pharmaceuticals2017-08-15Not applicableUs
Esterified Estrogens and MethyltestosteroneEstrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1)TabletOralANI Pharmaceuticals, Inc.2010-12-22Not applicableUs
Esterified Estrogens and MethyltestosteroneEstrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1)TabletOralMethod Pharmaceuticals2017-08-15Not applicableUs
Esterified Estrogens and MethyltestosteroneEstrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1)TabletOralANI Pharmaceuticals, Inc.2010-12-22Not applicableUs
International/Other Brands
Amnestrogen / Estratab / Evex / Femogen
Categories
UNII
3ASP8Q3768
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Esterified estrogens are indicated to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. It is also indicated for the treatment of symptoms of breast cancer in both men and women. In men it can be used for the treatment of advanced prostate cancer. It is also indicated for the treatment of menopausal symptoms.

Associated Conditions
Pharmacodynamics

Estrogens are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Estradiol is the principle intracellular human estrogen and is more potent than estrone and estriol at the receptor level; it is the primary estrogen secreted prior to menopause.

Mechanism of action

Estrogens modulate the pituitary secretion of gonadotropins, luteinizing hormone, and follicle-stimulating hormone through a negative feedback system; estrogen replacement reduces elevated levels of these hormones.

Absorption

Readily absorbed after oral administration. High concentrations of estrone are achieved with oral administration, whereas higher concentrations of estradiol are generally achieved after percutaneous absorption. Although vaginal products (such as gel, rings, etc.) are administered locally, they achieve high serum concentrations.

Volume of distribution

The distribution of exogenous estrogens is similar to that of endogenous estrogens. Estrogens are widely distributed in the body and are generally found in higher concentration in the sex hormone target organs.

Protein binding

Approximately 95-98% of estradiol is bound loosely to albumin or tightly to sex hormone binding globulin.

Metabolism

Hepatic; partial metabolism via CYP3A4 enzymes; estradiol is reversibly converted to estrone and estriol; oral estradiol also undergoes enterohepatic recirculation by conjugation in the liver, followed by excretion of sulfate and glucuronide conjugates into the bile, then hydrolysis in the intestine and estrogen reabsorption. Sulfate conjugates are the primary form found in postmenopausal women.

Route of elimination

Mainly urinary as estradiol, estrone, estriol, and their glucuronide and sulfate conjugates.

Half life

Half-life varies, it is in the range 1-2 hr.

Clearance

There is variation in the clearance rate depends on each estrogen individual: estradiol-17β: 580 L/day/m2 estrone: 4050 L/day/m2 estriol: 1110 L/day/m2

Toxicity

LD50 IP 325 mg/Kg (rat). LD50 IV 1740 mg/Kg (mouse). LD50 oral >5000 mg/Kg (rat).

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Estrogens, esterified.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Estrogens, esterified.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Estrogens, esterified.Experimental, Illicit
AbciximabEstrogens, esterified may decrease the anticoagulant activities of Abciximab.Approved
AceclofenacAceclofenac may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
AcenocoumarolEstrogens, esterified may decrease the anticoagulant activities of Acenocoumarol.Approved, Investigational
AcetaminophenAcetaminophen may increase the thrombogenic activities of Estrogens, esterified.Approved
Acetyl sulfisoxazoleThe metabolism of Estrogens, esterified can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
Acetylsalicylic acidAcetylsalicylic acid may increase the thrombogenic activities of Estrogens, esterified.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Estrogens, esterified.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Estrogens, esterified.Experimental, Investigational
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be increased when it is combined with Estrogens, esterified.Experimental, Investigational
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Estrogens, esterified.Approved
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Estrogens, esterified.Approved
Aminosalicylic AcidAminosalicylic Acid may increase the thrombogenic activities of Estrogens, esterified.Approved
AmiodaroneThe metabolism of Estrogens, esterified can be decreased when combined with Amiodarone.Approved, Investigational
AnastrozoleThe therapeutic efficacy of Anastrozole can be decreased when used in combination with Estrogens, esterified.Approved, Investigational
AncrodEstrogens, esterified may decrease the anticoagulant activities of Ancrod.Approved, Investigational
AndrostenedioneThe serum concentration of Androstenedione can be increased when it is combined with Estrogens, esterified.Experimental, Illicit
AnecortaveThe serum concentration of Anecortave can be increased when it is combined with Estrogens, esterified.Investigational
anecortave acetateThe serum concentration of anecortave acetate can be increased when it is combined with Estrogens, esterified.Investigational
Anthrax immune globulin humanEstrogens, esterified may increase the thrombogenic activities of Anthrax immune globulin human.Approved
AntipyrineAntipyrine may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
Antithrombin III humanEstrogens, esterified may decrease the anticoagulant activities of Antithrombin III human.Approved
AntrafenineAntrafenine may increase the thrombogenic activities of Estrogens, esterified.Approved
ApalutamideThe serum concentration of Estrogens, esterified can be decreased when it is combined with Apalutamide.Approved, Investigational
ApixabanEstrogens, esterified may decrease the anticoagulant activities of Apixaban.Approved
AprepitantThe serum concentration of Estrogens, esterified can be increased when it is combined with Aprepitant.Approved, Investigational
ArdeparinEstrogens, esterified may decrease the anticoagulant activities of Ardeparin.Approved, Investigational, Withdrawn
ArgatrobanEstrogens, esterified may decrease the anticoagulant activities of Argatroban.Approved, Investigational
AtamestaneThe serum concentration of Atamestane can be increased when it is combined with Estrogens, esterified.Investigational
AtazanavirThe metabolism of Estrogens, esterified can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Estrogens, esterified can be decreased when combined with Atomoxetine.Approved
BalsalazideBalsalazide may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
BecaplerminEstrogens, esterified may decrease the anticoagulant activities of Becaplermin.Approved, Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Estrogens, esterified.Approved, Investigational
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
BivalirudinEstrogens, esterified may decrease the anticoagulant activities of Bivalirudin.Approved, Investigational
BortezomibThe metabolism of Estrogens, esterified can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Bosentan.Approved, Investigational
BromfenacBromfenac may increase the thrombogenic activities of Estrogens, esterified.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Estrogens, esterified.Approved
BufexamacBufexamac may increase the thrombogenic activities of Estrogens, esterified.Approved, Experimental
Capromab pendetideEstrogens, esterified may decrease effectiveness of Capromab pendetide as a diagnostic agent.Approved
CapsaicinCapsaicin may increase the thrombogenic activities of Estrogens, esterified.Approved
CarbamazepineThe metabolism of Estrogens, esterified can be increased when combined with Carbamazepine.Approved, Investigational
CarprofenCarprofen may increase the thrombogenic activities of Estrogens, esterified.Approved, Vet Approved, Withdrawn
CelecoxibCelecoxib may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
CeritinibThe serum concentration of Estrogens, esterified can be increased when it is combined with Ceritinib.Approved
CertoparinEstrogens, esterified may decrease the anticoagulant activities of Certoparin.Approved, Investigational
Chenodeoxycholic acidThe therapeutic efficacy of Chenodeoxycholic acid can be decreased when used in combination with Estrogens, esterified.Approved
ChlorphenesinChlorphenesin may increase the thrombogenic activities of Estrogens, esterified.Approved, Vet Approved, Withdrawn
Choline magnesium trisalicylateCholine magnesium trisalicylate may increase the thrombogenic activities of Estrogens, esterified.Approved
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Estrogens, esterified.Approved, Investigational
CimicoxibCimicoxib may increase the thrombogenic activities of Estrogens, esterified.Investigational
CisplatinCisplatin may increase the thrombogenic activities of Estrogens, esterified.Approved
Citric AcidEstrogens, esterified may decrease the anticoagulant activities of Citric Acid.Approved, Nutraceutical, Vet Approved
ClarithromycinThe metabolism of Estrogens, esterified can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Estrogens, esterified can be decreased when combined with Clemastine.Approved, Investigational
ClobetasolThe serum concentration of Clobetasol can be increased when it is combined with Estrogens, esterified.Approved, Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Estrogens, esterified.Approved
ClobetasoneThe serum concentration of Clobetasone can be increased when it is combined with Estrogens, esterified.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Estrogens, esterified.Approved
Clodronic AcidClodronic Acid may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational, Vet Approved
ClotrimazoleThe metabolism of Estrogens, esterified can be decreased when combined with Clotrimazole.Approved, Vet Approved
Conestat alfaEstrogens, esterified may increase the thrombogenic activities of Conestat alfa.Approved, Investigational
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Estrogens, esterified.Approved, Investigational
Cortexolone 17α-propionateThe serum concentration of Cortexolone 17α-propionate can be increased when it is combined with Estrogens, esterified.Investigational
CorticosteroneThe serum concentration of Corticosterone can be increased when it is combined with Estrogens, esterified.Experimental
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Estrogens, esterified.Approved, Investigational
CrizotinibThe metabolism of Estrogens, esterified can be decreased when combined with Crizotinib.Approved
CurcuminThe metabolism of Estrogens, esterified can be decreased when combined with Curcumin.Approved, Investigational
CyclosporineThe metabolism of Estrogens, esterified can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
Dabigatran etexilateEstrogens, esterified may decrease the anticoagulant activities of Dabigatran etexilate.Approved
DabrafenibThe serum concentration of Estrogens, esterified can be decreased when it is combined with Dabrafenib.Approved, Investigational
DalteparinEstrogens, esterified may decrease the anticoagulant activities of Dalteparin.Approved
DanaparoidEstrogens, esterified may decrease the anticoagulant activities of Danaparoid.Approved, Withdrawn
DarexabanEstrogens, esterified may decrease the anticoagulant activities of Darexaban.Investigational
DarunavirThe metabolism of Estrogens, esterified can be decreased when combined with Darunavir.Approved
DasatinibThe serum concentration of Estrogens, esterified can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of Estrogens, esterified can be decreased when it is combined with Deferasirox.Approved, Investigational
DeflazacortThe serum concentration of Deflazacort can be increased when it is combined with Estrogens, esterified.Approved, Investigational
DelavirdineThe metabolism of Estrogens, esterified can be decreased when combined with Delavirdine.Approved
DesirudinEstrogens, esterified may decrease the anticoagulant activities of Desirudin.Approved
DesonideThe serum concentration of Desonide can be increased when it is combined with Estrogens, esterified.Approved, Investigational
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Estrogens, esterified.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Estrogens, esterified.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Estrogens, esterified.Experimental, Vet Approved
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Estrogens, esterified.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Estrogens, esterified.Vet Approved
DexibuprofenDexibuprofen may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
DexketoprofenDexketoprofen may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
DextranEstrogens, esterified may decrease the anticoagulant activities of Dextran.Approved, Investigational, Vet Approved
DiclofenacDiclofenac may increase the thrombogenic activities of Estrogens, esterified.Approved, Vet Approved
DicoumarolEstrogens, esterified may decrease the anticoagulant activities of Dicoumarol.Approved
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Estrogens, esterified.Approved
DiflunisalDiflunisal may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Estrogens, esterified.Approved, Investigational, Withdrawn
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Estrogens, esterified.Approved
DihydroergotamineThe metabolism of Estrogens, esterified can be decreased when combined with Dihydroergotamine.Approved, Investigational
DiltiazemThe metabolism of Estrogens, esterified can be decreased when combined with Diltiazem.Approved, Investigational
DoxycyclineThe metabolism of Estrogens, esterified can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronedaroneThe metabolism of Estrogens, esterified can be decreased when combined with Dronedarone.Approved
DrospirenoneDrospirenone may increase the thrombogenic activities of Estrogens, esterified.Approved
DroxicamDroxicam may increase the thrombogenic activities of Estrogens, esterified.Withdrawn
DyphyllineThe serum concentration of Dyphylline can be increased when it is combined with Estrogens, esterified.Approved
Edetic AcidEstrogens, esterified may decrease the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanEstrogens, esterified may decrease the anticoagulant activities of Edoxaban.Approved
EnoxaparinEstrogens, esterified may decrease the anticoagulant activities of Enoxaparin.Approved
EnzalutamideThe serum concentration of Estrogens, esterified can be decreased when it is combined with Enzalutamide.Approved
EquileninThe serum concentration of Equilenin can be increased when it is combined with Estrogens, esterified.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Estrogens, esterified.Approved
ErythromycinThe metabolism of Estrogens, esterified can be decreased when combined with Erythromycin.Approved, Investigational, Vet Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Estrogens, esterified.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Estrogens, esterified.Approved
EtanerceptEtanercept may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
Ethyl biscoumacetateEstrogens, esterified may decrease the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EtodolacEtodolac may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational, Vet Approved
EtoricoxibEtoricoxib may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
ExemestaneThe therapeutic efficacy of Exemestane can be decreased when used in combination with Estrogens, esterified.Approved, Investigational
FenoprofenFenoprofen may increase the thrombogenic activities of Estrogens, esterified.Approved
Ferulic acidEstrogens, esterified may decrease the anticoagulant activities of Ferulic acid.Experimental
Fish oilFish oil may increase the thrombogenic activities of Estrogens, esterified.Approved, Nutraceutical
FluasteroneThe serum concentration of Fluasterone can be increased when it is combined with Estrogens, esterified.Investigational
FluconazoleThe metabolism of Estrogens, esterified can be decreased when combined with Fluconazole.Approved, Investigational
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Estrogens, esterified.Approved, Investigational
FluindioneEstrogens, esterified may decrease the anticoagulant activities of Fluindione.Approved, Investigational
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Estrogens, esterified.Approved, Investigational
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Estrogens, esterified.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Estrogens, esterified.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Estrogens, esterified.Approved, Withdrawn
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Estrogens, esterified.Approved, Investigational
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Estrogens, esterified.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Estrogens, esterified.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Estrogens, esterified.Approved
FlurbiprofenFlurbiprofen may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
FluticasoneThe serum concentration of Fluticasone can be increased when it is combined with Estrogens, esterified.Approved, Experimental, Investigational
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Estrogens, esterified.Approved
Fluticasone propionateThe serum concentration of Fluticasone propionate can be increased when it is combined with Estrogens, esterified.Approved
FluvoxamineThe metabolism of Estrogens, esterified can be decreased when combined with Fluvoxamine.Approved, Investigational
FondaparinuxEstrogens, esterified may decrease the anticoagulant activities of Fondaparinux.Approved, Investigational
Fondaparinux sodiumEstrogens, esterified may decrease the anticoagulant activities of Fondaparinux sodium.Approved, Investigational
FormestaneThe serum concentration of Formestane can be increased when it is combined with Estrogens, esterified.Approved, Investigational, Withdrawn
FosamprenavirThe metabolism of Estrogens, esterified can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Estrogens, esterified can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Estrogens, esterified can be increased when combined with Fosphenytoin.Approved, Investigational
Fusidic AcidThe serum concentration of Estrogens, esterified can be increased when it is combined with Fusidic Acid.Approved, Investigational
GabexateEstrogens, esterified may decrease the anticoagulant activities of Gabexate.Investigational
GinsengGinseng may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational, Nutraceutical
HalcinonideThe serum concentration of Halcinonide can be increased when it is combined with Estrogens, esterified.Approved, Investigational, Withdrawn
HE3286The serum concentration of HE3286 can be increased when it is combined with Estrogens, esterified.Investigational
HeparinEstrogens, esterified may decrease the anticoagulant activities of Heparin.Approved, Investigational
Human C1-esterase inhibitorEstrogens, esterified may increase the thrombogenic activities of Human C1-esterase inhibitor.Approved
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Estrogens, esterified.Approved, Investigational
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
IbuprofenIbuprofen may increase the thrombogenic activities of Estrogens, esterified.Approved
IcosapentIcosapent may increase the thrombogenic activities of Estrogens, esterified.Approved, Nutraceutical
IdelalisibThe metabolism of Estrogens, esterified can be decreased when combined with Idelalisib.Approved
IdraparinuxEstrogens, esterified may decrease the anticoagulant activities of Idraparinux.Investigational
ImatinibThe metabolism of Estrogens, esterified can be decreased when combined with Imatinib.Approved
IndinavirThe metabolism of Estrogens, esterified can be decreased when combined with Indinavir.Approved
IndomethacinIndomethacin may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
IsavuconazoleThe serum concentration of Estrogens, esterified can be increased when it is combined with Isavuconazole.Approved, Investigational
IsavuconazoniumThe metabolism of Estrogens, esterified can be decreased when combined with Isavuconazonium.Approved, Investigational
IsradipineThe metabolism of Estrogens, esterified can be decreased when combined with Isradipine.Approved, Investigational
IstaroximeThe serum concentration of Istaroxime can be increased when it is combined with Estrogens, esterified.Investigational
ItraconazoleThe metabolism of Estrogens, esterified can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Estrogens, esterified can be increased when it is combined with Ivacaftor.Approved
KetoconazoleThe metabolism of Estrogens, esterified can be decreased when combined with Ketoconazole.Approved, Investigational
KetoprofenKetoprofen may increase the thrombogenic activities of Estrogens, esterified.Approved, Vet Approved
KetorolacKetorolac may increase the thrombogenic activities of Estrogens, esterified.Approved
LenalidomideEstrogens, esterified may increase the thrombogenic activities of Lenalidomide.Approved
LepirudinEstrogens, esterified may decrease the anticoagulant activities of Lepirudin.Approved
LetaxabanEstrogens, esterified may decrease the anticoagulant activities of Letaxaban.Investigational
LevothyroxineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Estrogens, esterified.Approved
LiothyronineThe therapeutic efficacy of Liothyronine can be decreased when used in combination with Estrogens, esterified.Approved, Vet Approved
LiotrixThe therapeutic efficacy of Liotrix can be decreased when used in combination with Estrogens, esterified.Approved
LopinavirThe metabolism of Estrogens, esterified can be decreased when combined with Lopinavir.Approved
LornoxicamLornoxicam may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
LorpiprazoleThe serum concentration of Estrogens, esterified can be increased when it is combined with Lorpiprazole.Approved
LoteprednolThe serum concentration of Loteprednol can be increased when it is combined with Estrogens, esterified.Approved
LovastatinThe metabolism of Estrogens, esterified can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Estrogens, esterified can be increased when it is combined with Luliconazole.Approved
LumiracoxibLumiracoxib may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
Magnesium salicylateMagnesium salicylate may increase the thrombogenic activities of Estrogens, esterified.Approved
ME-609The serum concentration of ME-609 can be increased when it is combined with Estrogens, esterified.Investigational
Meclofenamic acidMeclofenamic acid may increase the thrombogenic activities of Estrogens, esterified.Approved, Vet Approved
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Estrogens, esterified.Approved
Mefenamic acidMefenamic acid may increase the thrombogenic activities of Estrogens, esterified.Approved
MelagatranEstrogens, esterified may decrease the anticoagulant activities of Melagatran.Experimental
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Estrogens, esterified.Vet Approved
MeloxicamMeloxicam may increase the thrombogenic activities of Estrogens, esterified.Approved, Vet Approved
MesalazineMesalazine may increase the thrombogenic activities of Estrogens, esterified.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
MifepristoneThe metabolism of Estrogens, esterified can be decreased when combined with Mifepristone.Approved, Investigational
MitotaneThe serum concentration of Estrogens, esterified can be decreased when it is combined with Mitotane.Approved
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
MorniflumateMorniflumate may increase the thrombogenic activities of Estrogens, esterified.Approved
NabumetoneNabumetone may increase the thrombogenic activities of Estrogens, esterified.Approved
NadroparinEstrogens, esterified may decrease the anticoagulant activities of Nadroparin.Approved, Investigational
NafamostatEstrogens, esterified may decrease the anticoagulant activities of Nafamostat.Approved, Investigational
NaproxenNaproxen may increase the thrombogenic activities of Estrogens, esterified.Approved, Vet Approved
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Estrogens, esterified.Investigational
NefazodoneThe metabolism of Estrogens, esterified can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Estrogens, esterified can be decreased when combined with Nelfinavir.Approved
NepafenacNepafenac may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
NetupitantThe serum concentration of Estrogens, esterified can be increased when it is combined with Netupitant.Approved, Investigational
NevirapineThe metabolism of Estrogens, esterified can be increased when combined with Nevirapine.Approved
Niflumic AcidNiflumic Acid may increase the thrombogenic activities of Estrogens, esterified.Approved
NilotinibThe metabolism of Estrogens, esterified can be decreased when combined with Nilotinib.Approved, Investigational
NimesulideNimesulide may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational, Withdrawn
OlaparibThe metabolism of Estrogens, esterified can be decreased when combined with Olaparib.Approved
Oleoyl-estroneThe serum concentration of Oleoyl-estrone can be increased when it is combined with Estrogens, esterified.Investigational
OsimertinibThe serum concentration of Estrogens, esterified can be increased when it is combined with Osimertinib.Approved
OspemifeneThe risk or severity of adverse effects can be increased when Estrogens, esterified is combined with Ospemifene.Approved, Investigational
OtamixabanEstrogens, esterified may decrease the anticoagulant activities of Otamixaban.Investigational
OxaprozinOxaprozin may increase the thrombogenic activities of Estrogens, esterified.Approved
PalbociclibThe serum concentration of Estrogens, esterified can be increased when it is combined with Palbociclib.Approved, Investigational
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Estrogens, esterified.Approved
ParecoxibParecoxib may increase the thrombogenic activities of Estrogens, esterified.Approved
Pentaerythritol TetranitrateEstrogens, esterified may decrease the anticoagulant activities of Pentaerythritol Tetranitrate.Approved
PentobarbitalThe metabolism of Estrogens, esterified can be increased when combined with Pentobarbital.Approved, Investigational, Vet Approved
Pentosan PolysulfateEstrogens, esterified may decrease the anticoagulant activities of Pentosan Polysulfate.Approved
PhenindioneEstrogens, esterified may decrease the anticoagulant activities of Phenindione.Approved, Investigational
PhenobarbitalThe metabolism of Estrogens, esterified can be increased when combined with Phenobarbital.Approved, Investigational
PhenprocoumonEstrogens, esterified may decrease the anticoagulant activities of Phenprocoumon.Approved, Investigational
PhenylbutazonePhenylbutazone may increase the thrombogenic activities of Estrogens, esterified.Approved, Vet Approved
PhenytoinThe metabolism of Estrogens, esterified can be increased when combined with Phenytoin.Approved, Vet Approved
PiroxicamPiroxicam may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
PitolisantThe serum concentration of Estrogens, esterified can be decreased when it is combined with Pitolisant.Approved, Investigational
PomalidomidePomalidomide may increase the thrombogenic activities of Estrogens, esterified.Approved
PosaconazoleThe metabolism of Estrogens, esterified can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
Potassium CitrateEstrogens, esterified may decrease the anticoagulant activities of Potassium Citrate.Approved, Investigational, Vet Approved
PrasteroneThe risk or severity of adverse effects can be increased when Prasterone is combined with Estrogens, esterified.Approved, Investigational, Nutraceutical
Prasterone sulfateThe serum concentration of Prasterone sulfate can be increased when it is combined with Estrogens, esterified.Investigational
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Estrogens, esterified.Approved, Investigational
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Estrogens, esterified.Approved, Experimental, Investigational
PrimidoneThe metabolism of Estrogens, esterified can be increased when combined with Primidone.Approved, Vet Approved
Protein CEstrogens, esterified may decrease the anticoagulant activities of Protein C.Approved
Protein S humanEstrogens, esterified may decrease the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeEstrogens, esterified may decrease the anticoagulant activities of Protocatechualdehyde.Approved
RanolazineThe metabolism of Estrogens, esterified can be decreased when combined with Ranolazine.Approved, Investigational
ResveratrolResveratrol may increase the thrombogenic activities of Estrogens, esterified.Approved, Experimental, Investigational
ReviparinEstrogens, esterified may decrease the anticoagulant activities of Reviparin.Approved, Investigational
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Estrogens, esterified.Approved
RivaroxabanEstrogens, esterified may decrease the anticoagulant activities of Rivaroxaban.Approved
RofecoxibRofecoxib may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational, Withdrawn
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Estrogens, esterified.Approved, Investigational
RucaparibThe metabolism of Estrogens, esterified can be decreased when combined with Rucaparib.Approved, Investigational
Salicylic acidSalicylic acid may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational, Vet Approved
SalsalateSalsalate may increase the thrombogenic activities of Estrogens, esterified.Approved
SaquinavirThe metabolism of Estrogens, esterified can be decreased when combined with Saquinavir.Approved, Investigational
SarilumabThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Sarilumab.Approved, Investigational
SeliciclibSeliciclib may increase the thrombogenic activities of Estrogens, esterified.Investigational
SildenafilThe metabolism of Estrogens, esterified can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Estrogens, esterified can be decreased when it is combined with Siltuximab.Approved, Investigational
SimeprevirThe serum concentration of Estrogens, esterified can be increased when it is combined with Simeprevir.Approved
Sodium CitrateEstrogens, esterified may decrease the anticoagulant activities of Sodium Citrate.Approved, Investigational
SomatotropinThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Estrogens, esterified.Approved, Investigational
St. John's WortThe serum concentration of Estrogens, esterified can be decreased when it is combined with St. John's Wort.Approved, Investigational, Nutraceutical
StiripentolThe serum concentration of Estrogens, esterified can be increased when it is combined with Stiripentol.Approved
SulfasalazineSulfasalazine may increase the thrombogenic activities of Estrogens, esterified.Approved
SulfisoxazoleThe metabolism of Estrogens, esterified can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulindacSulindac may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
SulodexideEstrogens, esterified may decrease the anticoagulant activities of Sulodexide.Approved, Investigational
SuprofenSuprofen may increase the thrombogenic activities of Estrogens, esterified.Approved, Withdrawn
TalniflumateTalniflumate may increase the thrombogenic activities of Estrogens, esterified.Approved
TelaprevirThe metabolism of Estrogens, esterified can be decreased when combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of Estrogens, esterified can be decreased when combined with Telithromycin.Approved
TenoxicamTenoxicam may increase the thrombogenic activities of Estrogens, esterified.Approved
ThalidomideEstrogens, esterified may increase the thrombogenic activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Estrogens, esterified.Approved
Thyroid, porcineThe therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Estrogens, esterified.Approved
Tiaprofenic acidTiaprofenic acid may increase the thrombogenic activities of Estrogens, esterified.Approved
TiclopidineThe metabolism of Estrogens, esterified can be decreased when combined with Ticlopidine.Approved
TipranavirEstrogens, esterified may increase the dermatologic adverse activities of Tipranavir.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Estrogens, esterified.Approved, Withdrawn
TocilizumabThe serum concentration of Estrogens, esterified can be decreased when it is combined with Tocilizumab.Approved
TolmetinTolmetin may increase the thrombogenic activities of Estrogens, esterified.Approved
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
Trolamine salicylateTrolamine salicylate may increase the thrombogenic activities of Estrogens, esterified.Approved
TroxerutinEstrogens, esterified may decrease the anticoagulant activities of Troxerutin.Investigational
UlobetasolThe serum concentration of Ulobetasol can be increased when it is combined with Estrogens, esterified.Approved
Ursodeoxycholic acidThe therapeutic efficacy of Ursodeoxycholic acid can be decreased when used in combination with Estrogens, esterified.Approved, Investigational
ValdecoxibValdecoxib may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational, Withdrawn
VemurafenibThe serum concentration of Estrogens, esterified can be decreased when it is combined with Vemurafenib.Approved
VenlafaxineThe metabolism of Estrogens, esterified can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Estrogens, esterified can be decreased when combined with Verapamil.Approved
Vitamin CThe serum concentration of Estrogens, esterified can be increased when it is combined with Vitamin C.Approved, Nutraceutical
WarfarinEstrogens, esterified may decrease the anticoagulant activities of Warfarin.Approved
XimelagatranEstrogens, esterified may decrease the anticoagulant activities of Ximelagatran.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Estrogens, esterified can be decreased when combined with Ziprasidone.Approved
Food Interactions
Not Available

References

General References
  1. MSDS [Link]
  2. product info [Link]
  3. product info [Link]
  4. article [Link]
External Links
PubChem Substance
347910451
Wikipedia
Esterified_estrogens
AHFS Codes
  • 68:16.04 — Estrogens

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentHot Flushes, Menopause, Postmenopause1
2CompletedTreatmentMenopause1
2TerminatedTreatmentCancer, Breast1
2TerminatedTreatmentMenopause2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Tablet, coatedOral
TabletOral
TabletOral0.3 mg
TabletOral0.625 mg
TabletOral.3 mg/1
TabletOral.625 mg/1
TabletOral1.25 mg/1
Tablet, film coatedOral.3 mg/1
Tablet, film coatedOral.625 mg/1
Tablet, film coatedOral1.25 mg/1
Tablet, film coatedOral2.5 mg/1
TabletOral1.25 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da

Drug created on November 30, 2015 12:10 / Updated on June 21, 2018 00:05