Estrogens, esterified

Identification

Name
Estrogens, esterified
Accession Number
DB09381
Type
Small Molecule
Groups
Approved
Description

Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of menopause such as hot flashes, vaginal dryness, vaginal burning or irritation, or other hormonal changes in the vagina. It is being also for the prevention and treatment of osteoporosis.

Synonyms
  • Esterified Estrogens
  • Estrogens, Esterified Component of Menrium
  • Estrogens,esterified
  • Menrium Component Estrogens, Esterified
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
EstragynTablet0.3 mgOralSearchlight Pharma Inc1980-12-31Not applicableCanada
EstragynTablet0.625 mgOralSearchlight Pharma Inc1974-12-31Not applicableCanada
Neo Estrone Tab 1.25mgTablet1.25 mgOralNeolab Inc1974-12-312008-04-02Canada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
MenestTablet.625 mg/1OralPhysicians Total Care, Inc.2008-09-05Not applicableUs
MenestTablet, film coated.3 mg/1OralPfizer Laboratories Div Pfizer Inc.1977-09-28Not applicableUs
MenestTablet1.25 mg/1OralPhysicians Total Care, Inc.2010-12-16Not applicableUs
MenestTablet, film coated1.25 mg/1OralPfizer Laboratories Div Pfizer Inc.1977-09-28Not applicableUs
MenestTablet, film coated2.5 mg/1OralPfizer Laboratories Div Pfizer Inc.1977-09-282017-10-18Us
MenestTablet.3 mg/1OralPhysicians Total Care, Inc.2010-12-09Not applicableUs
MenestTablet, film coated.625 mg/1OralPfizer Laboratories Div Pfizer Inc.1977-09-28Not applicableUs
MenestTablet, film coated.625 mg/1OralAvera Mc Kennan Hospital2015-11-23Not applicableUs
International/Other Brands
Amnestrogen / Estratab / Evex / Femogen
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
CovaryxEstrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1)Tablet, coatedOralCentrix Pharmaceutical2007-04-01Not applicableUs11528 0010 01 nlmimage10 5905aced
Covaryx HsEstrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1)Tablet, coatedOralCentrix Pharmaceutical2007-04-01Not applicableUs
EemtEstrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1)Tablet, coatedOralCreekwood Pharmaceuticals, Inc.2011-09-01Not applicableUs
Eemt HsEstrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1)Tablet, coatedOralCreekwood Pharmaceuticals, Inc.2011-09-01Not applicableUs
Esterified Estrogens and MethyltestosteroneEstrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1)TabletOralMethod Pharmaceuticals2017-08-15Not applicableUs
Esterified Estrogens and MethyltestosteroneEstrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1)TabletOralANI Pharmaceuticals, Inc.2010-12-22Not applicableUs
Esterified Estrogens and MethyltestosteroneEstrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1)TabletOralMethod Pharmaceuticals2017-08-15Not applicableUs
Esterified Estrogens and MethyltestosteroneEstrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1)TabletOralANI Pharmaceuticals, Inc.2010-12-22Not applicableUs
Categories
UNII
3ASP8Q3768
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Esterified estrogens are indicated to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. It is also indicated for the treatment of symptoms of breast cancer in both men and women. In men it can be used for the treatment of advanced prostate cancer. It is also indicated for the treatment of menopausal symptoms.

Structured Indications
Pharmacodynamics

Estrogens are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Estradiol is the principle intracellular human estrogen and is more potent than estrone and estriol at the receptor level; it is the primary estrogen secreted prior to menopause.

Mechanism of action

Estrogens modulate the pituitary secretion of gonadotropins, luteinizing hormone, and follicle-stimulating hormone through a negative feedback system; estrogen replacement reduces elevated levels of these hormones.

Absorption

Readily absorbed after oral administration. High concentrations of estrone are achieved with oral administration, whereas higher concentrations of estradiol are generally achieved after percutaneous absorption. Although vaginal products (such as gel, rings, etc.) are administered locally, they achieve high serum concentrations.

Volume of distribution

The distribution of exogenous estrogens is similar to that of endogenous estrogens. Estrogens are widely distributed in the body and are generally found in higher concentration in the sex hormone target organs.

Protein binding

Approximately 95-98% of estradiol is bound loosely to albumin or tightly to sex hormone binding globulin.

Metabolism

Hepatic; partial metabolism via CYP3A4 enzymes; estradiol is reversibly converted to estrone and estriol; oral estradiol also undergoes enterohepatic recirculation by conjugation in the liver, followed by excretion of sulfate and glucuronide conjugates into the bile, then hydrolysis in the intestine and estrogen reabsorption. Sulfate conjugates are the primary form found in postmenopausal women.

Route of elimination

Mainly urinary as estradiol, estrone, estriol, and their glucuronide and sulfate conjugates.

Half life

Half-life varies, it is in the range 1-2 hr.

Clearance

There is variation in the clearance rate depends on each estrogen individual: estradiol-17β: 580 L/day/m2 estrone: 4050 L/day/m2 estriol: 1110 L/day/m2

Toxicity

LD50 IP 325 mg/Kg (rat). LD50 IV 1740 mg/Kg (mouse). LD50 oral >5000 mg/Kg (rat).

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
1,10-PhenanthrolineThe serum concentration of Estrogens, esterified can be decreased when it is combined with 1,10-Phenanthroline.Experimental
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Estrogens, esterified.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Estrogens, esterified.Experimental, Illicit
3,4-DichloroisocoumarinThe serum concentration of Estrogens, esterified can be decreased when it is combined with 3,4-Dichloroisocoumarin.Experimental
4-(2-Aminoethyl)Benzenesulfonyl FluorideThe serum concentration of Estrogens, esterified can be decreased when it is combined with 4-(2-Aminoethyl)Benzenesulfonyl Fluoride.Experimental
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Estrogens, esterified.Experimental, Illicit
AbciximabEstrogens, esterified may decrease the anticoagulant activities of Abciximab.Approved
AcenocoumarolEstrogens, esterified may decrease the anticoagulant activities of Acenocoumarol.Approved
AcitretinThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Acitretin.Approved
AdapaleneThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Adapalene.Approved
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Estrogens, esterified.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Estrogens, esterified.Experimental, Investigational
AlitretinoinThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Alitretinoin.Approved, Investigational
AlogliptinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Alogliptin.Approved
Alpha-1-proteinase inhibitorThe serum concentration of Estrogens, esterified can be decreased when it is combined with Alpha-1-proteinase inhibitor.Approved
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be increased when it is combined with Estrogens, esterified.Experimental, Investigational
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Estrogens, esterified.Approved
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Estrogens, esterified.Approved
AmiodaroneThe metabolism of Estrogens, esterified can be decreased when combined with Amiodarone.Approved, Investigational
AmobarbitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Amobarbital.Approved, Illicit
AmprenavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Amprenavir.Approved
AnastrozoleThe therapeutic efficacy of Anastrozole can be decreased when used in combination with Estrogens, esterified.Approved, Investigational
AncrodEstrogens, esterified may decrease the anticoagulant activities of Ancrod.Investigational
AndrostenedioneThe serum concentration of Androstenedione can be increased when it is combined with Estrogens, esterified.Experimental, Illicit
AnecortaveThe serum concentration of Anecortave can be increased when it is combined with Estrogens, esterified.Investigational
anecortave acetateThe serum concentration of anecortave acetate can be increased when it is combined with Estrogens, esterified.Investigational
Anthrax immune globulin humanEstrogens, esterified may increase the thrombogenic activities of Anthrax immune globulin human.Approved
Antithrombin III humanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Antithrombin III human.Approved
ApixabanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Apixaban.Approved
AprepitantThe serum concentration of Estrogens, esterified can be decreased when it is combined with Aprepitant.Approved, Investigational
AprotininThe serum concentration of Estrogens, esterified can be decreased when it is combined with Aprotinin.Approved, Withdrawn
ArdeparinEstrogens, esterified may decrease the anticoagulant activities of Ardeparin.Approved, Investigational, Withdrawn
ArgatrobanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Argatroban.Approved, Investigational
ArmodafinilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Armodafinil.Approved, Investigational
ArtemetherThe serum concentration of Estrogens, esterified can be decreased when it is combined with Artemether.Approved
AsunaprevirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Asunaprevir.Approved, Investigational
AtamestaneThe serum concentration of Atamestane can be increased when it is combined with Estrogens, esterified.Investigational
AtazanavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Estrogens, esterified can be decreased when combined with Atomoxetine.Approved
BarbexacloneThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Barbexaclone.Experimental
BarbitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Barbital.Illicit
BatimastatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Batimastat.Experimental
BecaplerminEstrogens, esterified may decrease the anticoagulant activities of Becaplermin.Approved, Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Estrogens, esterified.Approved, Investigational
BenazeprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Benazepril.Approved, Investigational
BenzamidineThe serum concentration of Estrogens, esterified can be decreased when it is combined with Benzamidine.Experimental
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
BexaroteneThe serum concentration of Estrogens, esterified can be decreased when it is combined with Bexarotene.Approved, Investigational
BivalirudinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Bivalirudin.Approved, Investigational
BoceprevirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Boceprevir.Approved, Withdrawn
BortezomibThe metabolism of Estrogens, esterified can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Bosentan.Approved, Investigational
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Estrogens, esterified.Approved
CamostatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Camostat.Experimental
CandoxatrilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Candoxatril.Experimental
CandoxatrilatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Candoxatrilat.Experimental
Capromab pendetideEstrogens, esterified may decrease effectiveness of Capromab pendetide as a diagnostic agent.Approved
CaptoprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Captopril.Approved
CarbamazepineThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Carbamazepine.Approved, Investigational
CelecoxibCelecoxib may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
CeritinibThe serum concentration of Estrogens, esterified can be increased when it is combined with Ceritinib.Approved
CertoparinEstrogens, esterified may decrease the anticoagulant activities of Certoparin.Approved, Investigational
Chenodeoxycholic acidThe therapeutic efficacy of Chenodeoxycholic acid can be decreased when used in combination with Estrogens, esterified.Approved
CholesterolThe serum concentration of Estrogens, esterified can be decreased when it is combined with Cholesterol.Experimental, Investigational
CholestyramineThe serum concentration of Estrogens, esterified can be decreased when it is combined with Cholestyramine.Approved
ChymostatinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Chymostatin.Experimental
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Estrogens, esterified.Approved, Investigational
CilastatinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Cilastatin.Approved
CilazaprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Cilazapril.Approved
Citric AcidEstrogens, esterified may decrease the anticoagulant activities of Citric Acid.Approved, Nutraceutical, Vet Approved
ClarithromycinThe metabolism of Estrogens, esterified can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Estrogens, esterified can be decreased when combined with Clemastine.Approved
ClobazamThe serum concentration of Estrogens, esterified can be decreased when it is combined with Clobazam.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be increased when it is combined with Estrogens, esterified.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Estrogens, esterified.Approved
ClobetasoneThe serum concentration of Clobetasone can be increased when it is combined with Estrogens, esterified.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Estrogens, esterified.Approved
ClorindioneEstrogens, esterified may decrease the anticoagulant activities of Clorindione.Experimental
ClotrimazoleThe metabolism of Estrogens, esterified can be decreased when combined with Clotrimazole.Approved, Vet Approved
CobicistatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Cobicistat.Approved
ColesevelamThe serum concentration of Estrogens, esterified can be decreased when it is combined with Colesevelam.Approved
ColestipolThe serum concentration of Estrogens, esterified can be decreased when it is combined with Colestipol.Approved
Conestat alfaEstrogens, esterified may increase the thrombogenic activities of Conestat alfa.Approved
ConivaptanThe serum concentration of Estrogens, esterified can be increased when it is combined with Conivaptan.Approved, Investigational
Cortexolone 17α-propionateThe serum concentration of Cortexolone 17α-propionate can be increased when it is combined with Estrogens, esterified.Investigational
CorticosteroneThe serum concentration of Corticosterone can be increased when it is combined with Estrogens, esterified.Experimental
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Estrogens, esterified.Approved
CrizotinibThe metabolism of Estrogens, esterified can be decreased when combined with Crizotinib.Approved
CyclosporineThe metabolism of Estrogens, esterified can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
Dabigatran etexilateThe serum concentration of Estrogens, esterified can be decreased when it is combined with Dabigatran etexilate.Approved
DabrafenibThe serum concentration of Estrogens, esterified can be decreased when it is combined with Dabrafenib.Approved
DalteparinEstrogens, esterified may decrease the anticoagulant activities of Dalteparin.Approved
DanaparoidEstrogens, esterified may decrease the anticoagulant activities of Danaparoid.Approved, Withdrawn
DarexabanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Darexaban.Investigational
DarunavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Estrogens, esterified can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of Estrogens, esterified can be decreased when it is combined with Deferasirox.Approved, Investigational
DeflazacortThe serum concentration of Deflazacort can be increased when it is combined with Estrogens, esterified.Approved
DelanzomibThe serum concentration of Estrogens, esterified can be decreased when it is combined with Delanzomib.Investigational
DelaprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Delapril.Experimental
DelavirdineThe metabolism of Estrogens, esterified can be decreased when combined with Delavirdine.Approved
DesirudinEstrogens, esterified may decrease the anticoagulant activities of Desirudin.Approved
DesonideThe serum concentration of Desonide can be increased when it is combined with Estrogens, esterified.Approved, Investigational
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Estrogens, esterified.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Estrogens, esterified.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Estrogens, esterified.Experimental, Vet Approved
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Estrogens, esterified.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Estrogens, esterified.Vet Approved
DextranEstrogens, esterified may decrease the anticoagulant activities of Dextran.Approved, Vet Approved
Dextran 40Estrogens, esterified may decrease the anticoagulant activities of Dextran 40.Approved
Dextran 70Estrogens, esterified may decrease the anticoagulant activities of Dextran 70.Approved
Dextran 75Estrogens, esterified may decrease the anticoagulant activities of Dextran 75.Approved
DicoumarolEstrogens, esterified may decrease the anticoagulant activities of Dicoumarol.Approved
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Estrogens, esterified.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Estrogens, esterified.Approved, Investigational
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Estrogens, esterified.Approved
DihydroergotamineThe metabolism of Estrogens, esterified can be decreased when combined with Dihydroergotamine.Approved
DiltiazemThe metabolism of Estrogens, esterified can be decreased when combined with Diltiazem.Approved
DiphenadioneEstrogens, esterified may decrease the anticoagulant activities of Diphenadione.Experimental
DoxycyclineThe metabolism of Estrogens, esterified can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronedaroneThe metabolism of Estrogens, esterified can be decreased when combined with Dronedarone.Approved
DyphyllineThe serum concentration of Dyphylline can be increased when it is combined with Estrogens, esterified.Approved
EcabetThe serum concentration of Estrogens, esterified can be decreased when it is combined with Ecabet.Approved, Investigational
Edetic AcidEstrogens, esterified may decrease the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Edoxaban.Approved
ElafinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Elafin.Investigational
ElvitegravirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Elvitegravir.Approved
EnalaprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Enalaprilat.Approved
EnalkirenThe serum concentration of Estrogens, esterified can be decreased when it is combined with Enalkiren.Experimental
EnoxaparinEstrogens, esterified may decrease the anticoagulant activities of Enoxaparin.Approved
EnzalutamideThe serum concentration of Estrogens, esterified can be decreased when it is combined with Enzalutamide.Approved
Epigallocatechin GallateThe serum concentration of Estrogens, esterified can be decreased when it is combined with Epigallocatechin Gallate.Investigational
EquileninThe serum concentration of Equilenin can be increased when it is combined with Estrogens, esterified.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Estrogens, esterified.Approved
ErythromycinThe metabolism of Estrogens, esterified can be decreased when combined with Erythromycin.Approved, Vet Approved
Eslicarbazepine acetateThe serum concentration of Estrogens, esterified can be decreased when it is combined with Eslicarbazepine acetate.Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Estrogens, esterified.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Estrogens, esterified.Approved
Ethyl biscoumacetateEstrogens, esterified may decrease the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EtodolacEtodolac may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational, Vet Approved
EtoricoxibEtoricoxib may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
ExemestaneThe therapeutic efficacy of Exemestane can be decreased when used in combination with Estrogens, esterified.Approved, Investigational
ExenatideThe serum concentration of Estrogens, esterified can be decreased when it is combined with Exenatide.Approved, Investigational
FaldaprevirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Faldaprevir.Investigational
FelbamateThe serum concentration of Estrogens, esterified can be decreased when it is combined with Felbamate.Approved
Ferulic acidEstrogens, esterified may decrease the anticoagulant activities of Ferulic acid.Experimental
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Estrogens, esterified.Approved
fluasteroneThe serum concentration of fluasterone can be increased when it is combined with Estrogens, esterified.Investigational
FluconazoleThe metabolism of Estrogens, esterified can be decreased when combined with Fluconazole.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Estrogens, esterified.Approved
FluindioneEstrogens, esterified may decrease the anticoagulant activities of Fluindione.Investigational
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Estrogens, esterified.Approved, Investigational
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Estrogens, esterified.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Estrogens, esterified.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Estrogens, esterified.Approved, Withdrawn
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Estrogens, esterified.Approved
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Estrogens, esterified.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Estrogens, esterified.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Estrogens, esterified.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Estrogens, esterified.Approved
Fluticasone propionateThe serum concentration of Fluticasone propionate can be increased when it is combined with Estrogens, esterified.Approved
FluvoxamineThe metabolism of Estrogens, esterified can be decreased when combined with Fluvoxamine.Approved, Investigational
FondaparinuxEstrogens, esterified may decrease the anticoagulant activities of Fondaparinux.Investigational
Fondaparinux sodiumEstrogens, esterified may decrease the anticoagulant activities of Fondaparinux sodium.Approved, Investigational
FormestaneThe serum concentration of Formestane can be increased when it is combined with Estrogens, esterified.Approved, Investigational, Withdrawn
FosamprenavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Estrogens, esterified can be decreased when it is combined with Fosaprepitant.Approved
FosinoprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Fosinopril.Approved
FosphenytoinThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Fosphenytoin.Approved
Fusidic AcidThe serum concentration of Estrogens, esterified can be increased when it is combined with Fusidic Acid.Approved
GabexateThe serum concentration of Estrogens, esterified can be decreased when it is combined with Gabexate.Investigational
GeldanamycinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Geldanamycin.Experimental, Investigational
GM6001The serum concentration of Estrogens, esterified can be decreased when it is combined with GM6001.Experimental
GriseofulvinThe metabolism of Estrogens, esterified can be increased when combined with Griseofulvin.Approved, Vet Approved
HalcinonideThe serum concentration of Halcinonide can be increased when it is combined with Estrogens, esterified.Approved, Investigational, Withdrawn
HE3286The serum concentration of HE3286 can be increased when it is combined with Estrogens, esterified.Investigational
HeparinEstrogens, esterified may decrease the anticoagulant activities of Heparin.Approved, Investigational
HexobarbitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Hexobarbital.Approved
Human C1-esterase inhibitorEstrogens, esterified may increase the thrombogenic activities of Human C1-esterase inhibitor.Approved
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Estrogens, esterified.Approved, Investigational
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
IdraparinuxThe serum concentration of Estrogens, esterified can be decreased when it is combined with Idraparinux.Investigational
ImatinibThe metabolism of Estrogens, esterified can be decreased when combined with Imatinib.Approved
ImidaprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Imidapril.Investigational
IndinavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Indinavir.Approved
IsavuconazoniumThe metabolism of Estrogens, esterified can be decreased when combined with Isavuconazonium.Approved, Investigational
IsoflurophateThe serum concentration of Estrogens, esterified can be decreased when it is combined with Isoflurophate.Approved, Investigational, Withdrawn
IsotretinoinThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Isotretinoin.Approved
IsradipineThe metabolism of Estrogens, esterified can be decreased when combined with Isradipine.Approved
IstaroximeThe serum concentration of Istaroxime can be increased when it is combined with Estrogens, esterified.Investigational
ItraconazoleThe metabolism of Estrogens, esterified can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Estrogens, esterified can be increased when it is combined with Ivacaftor.Approved
IxazomibThe serum concentration of Estrogens, esterified can be decreased when it is combined with Ixazomib.Approved
KetoconazoleThe metabolism of Estrogens, esterified can be decreased when combined with Ketoconazole.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Estrogens, esterified.Approved, Investigational
LenalidomideEstrogens, esterified may increase the thrombogenic activities of Lenalidomide.Approved
LepirudinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Lepirudin.Approved
LetaxabanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Letaxaban.Investigational
LevothyroxineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Estrogens, esterified.Approved
LinagliptinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Linagliptin.Approved
LiothyronineThe therapeutic efficacy of Liothyronine can be decreased when used in combination with Estrogens, esterified.Approved, Vet Approved
LiotrixThe therapeutic efficacy of Liotrix can be decreased when used in combination with Estrogens, esterified.Approved
LisinoprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Lisinopril.Approved, Investigational
LopinavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Lopinavir.Approved
LoteprednolThe serum concentration of Loteprednol can be increased when it is combined with Estrogens, esterified.Approved
LovastatinThe metabolism of Estrogens, esterified can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Estrogens, esterified can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Estrogens, esterified can be decreased when it is combined with Lumacaftor.Approved
LumiracoxibLumiracoxib may increase the thrombogenic activities of Estrogens, esterified.Approved, Investigational
ME-609The serum concentration of ME-609 can be increased when it is combined with Estrogens, esterified.Investigational
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Estrogens, esterified.Approved
MelagatranThe serum concentration of Estrogens, esterified can be decreased when it is combined with Melagatran.Experimental
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Estrogens, esterified.Vet Approved
MethohexitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Methohexital.Approved
MethylphenobarbitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Methylphenobarbital.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
MetreleptinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Metreleptin.Approved
MifepristoneThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Mifepristone.Approved, Investigational
MitotaneThe serum concentration of Estrogens, esterified can be decreased when it is combined with Mitotane.Approved
ModafinilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Modafinil.Approved, Investigational
MoexiprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Moexipril.Approved
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
Mycophenolic acidThe serum concentration of Estrogens, esterified can be decreased when it is combined with Mycophenolic acid.Approved
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Estrogens, esterified can be decreased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.Experimental
NabumetoneNabumetone may increase the thrombogenic activities of Estrogens, esterified.Approved
NadroparinEstrogens, esterified may decrease the anticoagulant activities of Nadroparin.Approved
NafamostatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Nafamostat.Approved, Investigational
NafcillinThe metabolism of Estrogens, esterified can be increased when combined with Nafcillin.Approved
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Estrogens, esterified.Investigational
NefazodoneThe metabolism of Estrogens, esterified can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Nelfinavir.Approved
NetupitantThe serum concentration of Estrogens, esterified can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Estrogens, esterified can be decreased when it is combined with Nevirapine.Approved
NilotinibThe metabolism of Estrogens, esterified can be decreased when combined with Nilotinib.Approved, Investigational
NitroaspirinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Nitroaspirin.Investigational
OlaparibThe metabolism of Estrogens, esterified can be decreased when combined with Olaparib.Approved
Oleoyl-estroneThe serum concentration of Oleoyl-estrone can be increased when it is combined with Estrogens, esterified.Investigational
OmapatrilatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Omapatrilat.Investigational
OsimertinibThe serum concentration of Estrogens, esterified can be increased when it is combined with Osimertinib.Approved
OspemifeneThe risk or severity of adverse effects can be increased when Estrogens, esterified is combined with Ospemifene.Approved
OtamixabanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Otamixaban.Investigational
OxcarbazepineThe serum concentration of Estrogens, esterified can be decreased when it is combined with Oxcarbazepine.Approved
PalbociclibThe serum concentration of Estrogens, esterified can be increased when it is combined with Palbociclib.Approved
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Estrogens, esterified.Approved
ParecoxibParecoxib may increase the thrombogenic activities of Estrogens, esterified.Approved
Pentaerythritol TetranitrateEstrogens, esterified may decrease the anticoagulant activities of Pentaerythritol Tetranitrate.Approved
PentobarbitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Pentobarbital.Approved, Vet Approved
Pentosan PolysulfateEstrogens, esterified may decrease the anticoagulant activities of Pentosan Polysulfate.Approved
PerindoprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Perindopril.Approved
PhenindioneEstrogens, esterified may decrease the anticoagulant activities of Phenindione.Approved, Investigational
PhenobarbitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Phenobarbital.Approved
PhenprocoumonEstrogens, esterified may decrease the anticoagulant activities of Phenprocoumon.Approved, Investigational
PhenytoinThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Phenytoin.Approved, Vet Approved
PhosphoramidonThe serum concentration of Estrogens, esterified can be decreased when it is combined with Phosphoramidon.Experimental
PosaconazoleThe metabolism of Estrogens, esterified can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PrasteroneThe risk or severity of adverse effects can be increased when Prasterone is combined with Estrogens, esterified.Approved, Nutraceutical
Prasterone sulfateThe serum concentration of Prasterone sulfate can be increased when it is combined with Estrogens, esterified.Investigational
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Estrogens, esterified.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Estrogens, esterified.Experimental, Investigational
PrimidoneThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Primidone.Approved, Vet Approved
PrinomastatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Prinomastat.Investigational
Protein CEstrogens, esterified may decrease the anticoagulant activities of Protein C.Approved
Protein S humanEstrogens, esterified may decrease the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeEstrogens, esterified may decrease the anticoagulant activities of Protocatechualdehyde.Approved
PrucaloprideThe serum concentration of Estrogens, esterified can be decreased when it is combined with Prucalopride.Approved
QuinaprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Quinapril.Approved, Investigational
RacecadotrilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Racecadotril.Investigational
RamiprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Ramipril.Approved
RanolazineThe metabolism of Estrogens, esterified can be decreased when combined with Ranolazine.Approved, Investigational
RemikirenThe serum concentration of Estrogens, esterified can be decreased when it is combined with Remikiren.Approved
ReviparinEstrogens, esterified may decrease the anticoagulant activities of Reviparin.Approved, Investigational
RifabutinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Estrogens, esterified can be decreased when it is combined with Rifapentine.Approved
RifaximinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Rifaximin.Approved, Investigational
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Estrogens, esterified.Approved
RitonavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Rivaroxaban.Approved
RofecoxibRofecoxib may increase the thrombogenic activities of Estrogens, esterified.Investigational, Withdrawn
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Estrogens, esterified.Approved, Investigational
S-3304The serum concentration of Estrogens, esterified can be decreased when it is combined with S-3304.Investigational
SaquinavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Saxagliptin.Approved
SecobarbitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Secobarbital.Approved, Vet Approved
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Estrogens, esterified.Approved, Investigational, Vet Approved
SildenafilThe metabolism of Estrogens, esterified can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Estrogens, esterified can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Estrogens, esterified can be increased when it is combined with Simeprevir.Approved
SitagliptinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Sitagliptin.Approved, Investigational
SivelestatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Sivelestat.Investigational
SomatotropinThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Estrogens, esterified.Approved, Investigational
SpiraprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Spirapril.Approved
St. John's WortThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with St. John&#39;s Wort.Investigational, Nutraceutical
StiripentolThe serum concentration of Estrogens, esterified can be increased when it is combined with Stiripentol.Approved
SulfisoxazoleThe metabolism of Estrogens, esterified can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulodexideEstrogens, esterified may decrease the anticoagulant activities of Sulodexide.Approved, Investigational
TelaprevirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of Estrogens, esterified can be decreased when combined with Telithromycin.Approved
TemocaprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Temocapril.Experimental, Investigational
ThalidomideEstrogens, esterified may increase the thrombogenic activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Estrogens, esterified.Approved
ThiamylalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Thiamylal.Approved, Vet Approved
ThiopentalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Thiopental.Approved, Vet Approved
ThiorphanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Thiorphan.Experimental
Thyroid, porcineThe therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Estrogens, esterified.Approved
TiclopidineThe metabolism of Estrogens, esterified can be decreased when combined with Ticlopidine.Approved
TioclomarolEstrogens, esterified may decrease the anticoagulant activities of Tioclomarol.Experimental
TipranavirEstrogens, esterified may increase the dermatologic adverse activities of Tipranavir.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Estrogens, esterified.Approved
TocilizumabThe serum concentration of Estrogens, esterified can be decreased when it is combined with Tocilizumab.Approved
TopiramateThe serum concentration of Estrogens, esterified can be decreased when it is combined with Topiramate.Approved
TrandolaprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Trandolapril.Approved
Tranexamic AcidEstrogens, esterified may increase the thrombogenic activities of Tranexamic Acid.Approved
TretinoinThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Tretinoin.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Estrogens, esterified.Approved, Vet Approved
TroxerutinEstrogens, esterified may decrease the anticoagulant activities of Troxerutin.Investigational
UbenimexThe serum concentration of Estrogens, esterified can be decreased when it is combined with Ubenimex.Experimental, Investigational
UlinastatinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Ulinastatin.Investigational
UlobetasolThe serum concentration of Ulobetasol can be increased when it is combined with Estrogens, esterified.Approved
Ursodeoxycholic acidThe therapeutic efficacy of Ursodeoxycholic acid can be decreased when used in combination with Estrogens, esterified.Approved, Investigational
ValdecoxibValdecoxib may increase the thrombogenic activities of Estrogens, esterified.Investigational, Withdrawn
VenlafaxineThe metabolism of Estrogens, esterified can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Estrogens, esterified can be decreased when combined with Verapamil.Approved
VildagliptinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Vildagliptin.Approved, Investigational
Vitamin CThe serum concentration of Estrogens, esterified can be increased when it is combined with Vitamin C.Approved, Nutraceutical
VoriconazoleThe metabolism of Estrogens, esterified can be decreased when combined with Voriconazole.Approved, Investigational
WarfarinEstrogens, esterified may decrease the anticoagulant activities of Warfarin.Approved
XimelagatranThe serum concentration of Estrogens, esterified can be decreased when it is combined with Ximelagatran.Approved, Investigational, Withdrawn
Z-Val-Ala-Asp fluoromethyl ketoneThe serum concentration of Estrogens, esterified can be decreased when it is combined with Z-Val-Ala-Asp fluoromethyl ketone.Experimental
ZiprasidoneThe metabolism of Estrogens, esterified can be decreased when combined with Ziprasidone.Approved
ZofenoprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Zofenopril.Experimental
Food Interactions
Not Available

References

General References
  1. MSDS [Link]
  2. product info [Link]
  3. product info [Link]
  4. article [Link]
External Links
PubChem Substance
347910451
AHFS Codes
  • 68:16.04 — Estrogens

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentHot Flushes, Menopause, Postmenopause1
2CompletedTreatmentMenopause1
2TerminatedTreatmentCancer, Breast1
2TerminatedTreatmentMenopause2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Tablet, coatedOral
TabletOral
TabletOral0.3 mg
TabletOral0.625 mg
TabletOral.3 mg/1
TabletOral.625 mg/1
TabletOral1.25 mg/1
Tablet, film coatedOral.3 mg/1
Tablet, film coatedOral.625 mg/1
Tablet, film coatedOral1.25 mg/1
Tablet, film coatedOral2.5 mg/1
TabletOral1.25 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da

Drug created on November 30, 2015 12:10 / Updated on December 10, 2017 17:18