Estrogens, esterified

Identification

Name
Estrogens, esterified
Accession Number
DB09381
Type
Small Molecule
Groups
Approved
Description

Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of menopause such as hot flashes, vaginal dryness, vaginal burning or irritation, or other hormonal changes in the vagina. It is being also for the prevention and treatment of osteoporosis.

Structure
Thumb
Synonyms
  • Esterified Estrogens
  • Estrogens, Esterified Component of Menrium
  • Estrogens,esterified
  • Menrium Component Estrogens, Esterified
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
EstragynTablet0.625 mgOralSearchlight Pharma Inc1974-12-31Not applicableCanada
EstragynTablet0.3 mgOralSearchlight Pharma Inc1980-12-31Not applicableCanada
Neo Estrone Tab 1.25mgTablet1.25 mgOralNeolab Inc1974-12-312008-04-02Canada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
MenestTablet.625 mg/1OralPhysicians Total Care, Inc.2008-09-05Not applicableUs
MenestTablet, film coated.625 mg/1OralAvera Mc Kennan Hospital2015-11-23Not applicableUs
MenestTablet, film coated.625 mg/1OralPfizer Laboratories Div Pfizer Inc.1977-09-28Not applicableUs
MenestTablet.3 mg/1OralPhysicians Total Care, Inc.2010-12-09Not applicableUs
MenestTablet, film coated2.5 mg/1OralPfizer Laboratories Div Pfizer Inc.1977-09-282017-10-18Us
MenestTablet, film coated1.25 mg/1OralPfizer Laboratories Div Pfizer Inc.1977-09-28Not applicableUs
MenestTablet1.25 mg/1OralPhysicians Total Care, Inc.2010-12-16Not applicableUs
MenestTablet, film coated.3 mg/1OralPfizer Laboratories Div Pfizer Inc.1977-09-28Not applicableUs
International/Other Brands
Amnestrogen / Estratab / Evex / Femogen
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
CovaryxEstrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1)Tablet, coatedOralCentrix Pharmaceutical2007-04-01Not applicableUs11528 0010 01 nlmimage10 5905aced
Covaryx HsEstrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1)Tablet, coatedOralCentrix Pharmaceutical2007-04-01Not applicableUs
EemtEstrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1)Tablet, coatedOralCreekwood Pharmaceuticals, Inc.2011-09-01Not applicableUs
Eemt HsEstrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1)Tablet, coatedOralCreekwood Pharmaceuticals, Inc.2011-09-01Not applicableUs
Esterified Estrogens and MethyltestosteroneEstrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1)TabletOralMethod Pharmaceuticals2017-08-15Not applicableUs
Esterified Estrogens and MethyltestosteroneEstrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1)TabletOralANIP Acquisition Company2010-12-22Not applicableUs
Esterified Estrogens and MethyltestosteroneEstrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1)TabletOralMethod Pharmaceuticals2017-08-15Not applicableUs
Esterified Estrogens and MethyltestosteroneEstrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1)TabletOralANIP Acquisition Company2010-12-22Not applicableUs
Categories
UNII
3ASP8Q3768
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Esterified estrogens are indicated to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. It is also indicated for the treatment of symptoms of breast cancer in both men and women. In men it can be used for the treatment of advanced prostate cancer. It is also indicated for the treatment of menopausal symptoms.

Structured Indications
Pharmacodynamics

Estrogens are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Estradiol is the principle intracellular human estrogen and is more potent than estrone and estriol at the receptor level; it is the primary estrogen secreted prior to menopause.

Mechanism of action

Estrogens modulate the pituitary secretion of gonadotropins, luteinizing hormone, and follicle-stimulating hormone through a negative feedback system; estrogen replacement reduces elevated levels of these hormones.

Absorption

Readily absorbed after oral administration. High concentrations of estrone are achieved with oral administration, whereas higher concentrations of estradiol are generally achieved after percutaneous absorption. Although vaginal products (such as gel, rings, etc.) are administered locally, they achieve high serum concentrations.

Volume of distribution

The distribution of exogenous estrogens is similar to that of endogenous estrogens. Estrogens are widely distributed in the body and are generally found in higher concentration in the sex hormone target organs.

Protein binding

Approximately 95-98% of estradiol is bound loosely to albumin or tightly to sex hormone binding globulin.

Metabolism

Hepatic; partial metabolism via CYP3A4 enzymes; estradiol is reversibly converted to estrone and estriol; oral estradiol also undergoes enterohepatic recirculation by conjugation in the liver, followed by excretion of sulfate and glucuronide conjugates into the bile, then hydrolysis in the intestine and estrogen reabsorption. Sulfate conjugates are the primary form found in postmenopausal women.

Route of elimination

Mainly urinary as estradiol, estrone, estriol, and their glucuronide and sulfate conjugates.

Half life

Half-life varies, it is in the range 1-2 hr.

Clearance

There is variation in the clearance rate depends on each estrogen individual: estradiol-17β: 580 L/day/m2 estrone: 4050 L/day/m2 estriol: 1110 L/day/m2

Toxicity

LD50 IP 325 mg/Kg (rat). LD50 IV 1740 mg/Kg (mouse). LD50 oral >5000 mg/Kg (rat).

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
1,10-PhenanthrolineThe serum concentration of Estrogens, esterified can be decreased when it is combined with 1,10-Phenanthroline.Experimental
3,4-DichloroisocoumarinThe serum concentration of Estrogens, esterified can be decreased when it is combined with 3,4-Dichloroisocoumarin.Experimental
4-(2-Aminoethyl)Benzenesulfonyl FluorideThe serum concentration of Estrogens, esterified can be decreased when it is combined with 4-(2-Aminoethyl)Benzenesulfonyl Fluoride.Experimental
AcenocoumarolEstrogens, esterified may decrease the anticoagulant activities of Acenocoumarol.Approved
AcitretinThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Acitretin.Approved
AdapaleneThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Adapalene.Approved
AlitretinoinThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Alitretinoin.Approved, Investigational
AlogliptinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Alogliptin.Approved
Alpha-1-proteinase inhibitorThe serum concentration of Estrogens, esterified can be decreased when it is combined with Alpha-1-proteinase inhibitor.Approved
AmiodaroneThe metabolism of Estrogens, esterified can be decreased when combined with Amiodarone.Approved, Investigational
AmobarbitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Amobarbital.Approved, Illicit
AmprenavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Amprenavir.Approved
Antithrombin III humanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Antithrombin III human.Approved
ApixabanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Apixaban.Approved
AprepitantThe serum concentration of Estrogens, esterified can be decreased when it is combined with Aprepitant.Approved, Investigational
AprotininThe serum concentration of Estrogens, esterified can be decreased when it is combined with Aprotinin.Approved, Withdrawn
ArgatrobanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Argatroban.Approved, Investigational
ArmodafinilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Armodafinil.Approved, Investigational
ArtemetherThe serum concentration of Estrogens, esterified can be decreased when it is combined with Artemether.Approved
AsunaprevirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Asunaprevir.Approved, Investigational
AtazanavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Estrogens, esterified can be decreased when combined with Atomoxetine.Approved
BarbexacloneThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Barbexaclone.Experimental
BarbitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Barbital.Illicit
BatimastatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Batimastat.Experimental
BenazeprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Benazepril.Approved, Investigational
BenzamidineThe serum concentration of Estrogens, esterified can be decreased when it is combined with Benzamidine.Experimental
BexaroteneThe serum concentration of Estrogens, esterified can be decreased when it is combined with Bexarotene.Approved, Investigational
BivalirudinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Bivalirudin.Approved, Investigational
BoceprevirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Boceprevir.Withdrawn
BortezomibThe metabolism of Estrogens, esterified can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Bosentan.Approved, Investigational
CamostatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Camostat.Experimental
CandoxatrilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Candoxatril.Experimental
CandoxatrilatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Candoxatrilat.Experimental
CaptoprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Captopril.Approved
CarbamazepineThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Carbamazepine.Approved, Investigational
CeritinibThe serum concentration of Estrogens, esterified can be increased when it is combined with Ceritinib.Approved
CholesterolThe serum concentration of Estrogens, esterified can be decreased when it is combined with Cholesterol.Experimental
CholestyramineThe serum concentration of Estrogens, esterified can be decreased when it is combined with Cholestyramine.Approved
ChymostatinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Chymostatin.Experimental
CilastatinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Cilastatin.Approved
CilazaprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Cilazapril.Approved
ClarithromycinThe metabolism of Estrogens, esterified can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Estrogens, esterified can be decreased when combined with Clemastine.Approved
ClobazamThe serum concentration of Estrogens, esterified can be decreased when it is combined with Clobazam.Approved, Illicit
ClorindioneEstrogens, esterified may decrease the anticoagulant activities of Clorindione.Experimental
ClotrimazoleThe metabolism of Estrogens, esterified can be decreased when combined with Clotrimazole.Approved, Vet Approved
CobicistatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Cobicistat.Approved
ColesevelamThe serum concentration of Estrogens, esterified can be decreased when it is combined with Colesevelam.Approved
ColestipolThe serum concentration of Estrogens, esterified can be decreased when it is combined with Colestipol.Approved
ConivaptanThe serum concentration of Estrogens, esterified can be increased when it is combined with Conivaptan.Approved, Investigational
CrizotinibThe metabolism of Estrogens, esterified can be decreased when combined with Crizotinib.Approved
CyclosporineThe metabolism of Estrogens, esterified can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
Dabigatran etexilateThe serum concentration of Estrogens, esterified can be decreased when it is combined with Dabigatran etexilate.Approved
DabrafenibThe serum concentration of Estrogens, esterified can be decreased when it is combined with Dabrafenib.Approved
DarexabanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Darexaban.Investigational
DarunavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Estrogens, esterified can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of Estrogens, esterified can be decreased when it is combined with Deferasirox.Approved, Investigational
DelanzomibThe serum concentration of Estrogens, esterified can be decreased when it is combined with Delanzomib.Investigational
DelaprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Delapril.Experimental
DelavirdineThe metabolism of Estrogens, esterified can be decreased when combined with Delavirdine.Approved
DicoumarolEstrogens, esterified may decrease the anticoagulant activities of Dicoumarol.Approved
DihydroergotamineThe metabolism of Estrogens, esterified can be decreased when combined with Dihydroergotamine.Approved
DiltiazemThe metabolism of Estrogens, esterified can be decreased when combined with Diltiazem.Approved
DiphenadioneEstrogens, esterified may decrease the anticoagulant activities of Diphenadione.Experimental
DoxycyclineThe metabolism of Estrogens, esterified can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronedaroneThe metabolism of Estrogens, esterified can be decreased when combined with Dronedarone.Approved
EcabetThe serum concentration of Estrogens, esterified can be decreased when it is combined with Ecabet.Approved, Investigational
EdoxabanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Edoxaban.Approved
ElafinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Elafin.Investigational
ElvitegravirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Elvitegravir.Approved
EnalaprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Enalaprilat.Approved
EnalkirenThe serum concentration of Estrogens, esterified can be decreased when it is combined with Enalkiren.Experimental
EnzalutamideThe serum concentration of Estrogens, esterified can be decreased when it is combined with Enzalutamide.Approved
Epigallocatechin GallateThe serum concentration of Estrogens, esterified can be decreased when it is combined with Epigallocatechin Gallate.Investigational
ErythromycinThe metabolism of Estrogens, esterified can be decreased when combined with Erythromycin.Approved, Vet Approved
Eslicarbazepine acetateThe serum concentration of Estrogens, esterified can be decreased when it is combined with Eslicarbazepine acetate.Approved
Ethyl biscoumacetateEstrogens, esterified may decrease the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
ExenatideThe serum concentration of Estrogens, esterified can be decreased when it is combined with Exenatide.Approved, Investigational
FaldaprevirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Faldaprevir.Investigational
FelbamateThe serum concentration of Estrogens, esterified can be decreased when it is combined with Felbamate.Approved
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Estrogens, esterified.Approved
FluconazoleThe metabolism of Estrogens, esterified can be decreased when combined with Fluconazole.Approved
FluindioneEstrogens, esterified may decrease the anticoagulant activities of Fluindione.Investigational
FluvoxamineThe metabolism of Estrogens, esterified can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Estrogens, esterified can be decreased when it is combined with Fosaprepitant.Approved
FosinoprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Fosinopril.Approved
FosphenytoinThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Fosphenytoin.Approved
Fusidic AcidThe serum concentration of Estrogens, esterified can be increased when it is combined with Fusidic Acid.Approved
GabexateThe serum concentration of Estrogens, esterified can be decreased when it is combined with Gabexate.Investigational
GeldanamycinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Geldanamycin.Experimental
GM6001The serum concentration of Estrogens, esterified can be decreased when it is combined with GM6001.Experimental
GriseofulvinThe metabolism of Estrogens, esterified can be increased when combined with Griseofulvin.Approved, Vet Approved
HexobarbitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Hexobarbital.Approved
IdelalisibThe serum concentration of Estrogens, esterified can be increased when it is combined with Idelalisib.Approved
IdraparinuxThe serum concentration of Estrogens, esterified can be decreased when it is combined with Idraparinux.Investigational
ImatinibThe metabolism of Estrogens, esterified can be decreased when combined with Imatinib.Approved
ImidaprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Imidapril.Investigational
IndinavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Indinavir.Approved
IsavuconazoniumThe metabolism of Estrogens, esterified can be decreased when combined with Isavuconazonium.Approved, Investigational
IsoflurophateThe serum concentration of Estrogens, esterified can be decreased when it is combined with Isoflurophate.Approved, Withdrawn
IsotretinoinThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Isotretinoin.Approved
IsradipineThe metabolism of Estrogens, esterified can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Estrogens, esterified can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Estrogens, esterified can be increased when it is combined with Ivacaftor.Approved
IxazomibThe serum concentration of Estrogens, esterified can be decreased when it is combined with Ixazomib.Approved
KetoconazoleThe metabolism of Estrogens, esterified can be decreased when combined with Ketoconazole.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Estrogens, esterified.Approved, Investigational
LepirudinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Lepirudin.Approved
LetaxabanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Letaxaban.Investigational
LinagliptinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Linagliptin.Approved
LisinoprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Lisinopril.Approved, Investigational
LopinavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Lopinavir.Approved
LovastatinThe metabolism of Estrogens, esterified can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Estrogens, esterified can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Estrogens, esterified can be decreased when it is combined with Lumacaftor.Approved
MelagatranThe serum concentration of Estrogens, esterified can be decreased when it is combined with Melagatran.Experimental
MethohexitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Methohexital.Approved
MethylphenobarbitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Methylphenobarbital.Approved
MetreleptinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Metreleptin.Approved
MifepristoneThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Mifepristone.Approved, Investigational
MitotaneThe serum concentration of Estrogens, esterified can be decreased when it is combined with Mitotane.Approved
ModafinilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Modafinil.Approved, Investigational
MoexiprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Moexipril.Approved
Mycophenolic acidThe serum concentration of Estrogens, esterified can be decreased when it is combined with Mycophenolic acid.Approved
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Estrogens, esterified can be decreased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.Experimental
NafamostatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Nafamostat.Approved, Investigational
NafcillinThe metabolism of Estrogens, esterified can be increased when combined with Nafcillin.Approved
NefazodoneThe metabolism of Estrogens, esterified can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Nelfinavir.Approved
NetupitantThe serum concentration of Estrogens, esterified can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Estrogens, esterified can be decreased when it is combined with Nevirapine.Approved
NilotinibThe metabolism of Estrogens, esterified can be decreased when combined with Nilotinib.Approved, Investigational
NitroaspirinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Nitroaspirin.Investigational
OlaparibThe metabolism of Estrogens, esterified can be decreased when combined with Olaparib.Approved
OmapatrilatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Omapatrilat.Investigational
OsimertinibThe serum concentration of Estrogens, esterified can be increased when it is combined with Osimertinib.Approved
OtamixabanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Otamixaban.Investigational
OxcarbazepineThe serum concentration of Estrogens, esterified can be decreased when it is combined with Oxcarbazepine.Approved
PalbociclibThe serum concentration of Estrogens, esterified can be increased when it is combined with Palbociclib.Approved
PentobarbitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Pentobarbital.Approved, Vet Approved
PerindoprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Perindopril.Approved
PhenindioneEstrogens, esterified may decrease the anticoagulant activities of Phenindione.Approved
PhenobarbitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Phenobarbital.Approved
PhenprocoumonEstrogens, esterified may decrease the anticoagulant activities of Phenprocoumon.Approved
PhenytoinThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Phenytoin.Approved, Vet Approved
PhosphoramidonThe serum concentration of Estrogens, esterified can be decreased when it is combined with Phosphoramidon.Experimental
PosaconazoleThe metabolism of Estrogens, esterified can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PrimidoneThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Primidone.Approved, Vet Approved
PrinomastatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Prinomastat.Investigational
PrucaloprideThe serum concentration of Estrogens, esterified can be decreased when it is combined with Prucalopride.Approved
QuinaprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Quinapril.Approved, Investigational
RacecadotrilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Racecadotril.Investigational
RamiprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Ramipril.Approved
RanolazineThe metabolism of Estrogens, esterified can be decreased when combined with Ranolazine.Approved, Investigational
RemikirenThe serum concentration of Estrogens, esterified can be decreased when it is combined with Remikiren.Approved
RifabutinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Estrogens, esterified can be decreased when it is combined with Rifapentine.Approved
RitonavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Rivaroxaban.Approved
S-3304The serum concentration of Estrogens, esterified can be decreased when it is combined with S-3304.Investigational
SaquinavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Saxagliptin.Approved
SecobarbitalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Secobarbital.Approved, Vet Approved
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Estrogens, esterified.Approved, Investigational, Vet Approved
SildenafilThe metabolism of Estrogens, esterified can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Estrogens, esterified can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Estrogens, esterified can be increased when it is combined with Simeprevir.Approved
SitagliptinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Sitagliptin.Approved, Investigational
SivelestatThe serum concentration of Estrogens, esterified can be decreased when it is combined with Sivelestat.Investigational
SpiraprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Spirapril.Approved
St. John's WortThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with St. John&#39;s Wort.Nutraceutical
StiripentolThe serum concentration of Estrogens, esterified can be increased when it is combined with Stiripentol.Approved
SulfisoxazoleThe metabolism of Estrogens, esterified can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
TelaprevirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Telaprevir.Withdrawn
TelithromycinThe metabolism of Estrogens, esterified can be decreased when combined with Telithromycin.Approved
TemocaprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Temocapril.Experimental, Investigational
ThalidomideEstrogens, esterified may increase the thrombogenic activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Thiamylal.Approved, Vet Approved
ThiopentalThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Thiopental.Approved, Vet Approved
ThiorphanThe serum concentration of Estrogens, esterified can be decreased when it is combined with Thiorphan.Experimental
TiclopidineThe metabolism of Estrogens, esterified can be decreased when combined with Ticlopidine.Approved
TioclomarolEstrogens, esterified may decrease the anticoagulant activities of Tioclomarol.Experimental
TipranavirThe serum concentration of Estrogens, esterified can be decreased when it is combined with Tipranavir.Approved, Investigational
TocilizumabThe serum concentration of Estrogens, esterified can be decreased when it is combined with Tocilizumab.Approved
TopiramateThe serum concentration of Estrogens, esterified can be decreased when it is combined with Topiramate.Approved
TrandolaprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Trandolapril.Approved
Tranexamic AcidEstrogens, esterified may increase the thrombogenic activities of Tranexamic Acid.Approved
TretinoinThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Tretinoin.Approved, Investigational, Nutraceutical
UbenimexThe serum concentration of Estrogens, esterified can be decreased when it is combined with Ubenimex.Experimental
UlinastatinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Ulinastatin.Investigational
VenlafaxineThe metabolism of Estrogens, esterified can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Estrogens, esterified can be decreased when combined with Verapamil.Approved
VildagliptinThe serum concentration of Estrogens, esterified can be decreased when it is combined with Vildagliptin.Approved, Investigational
VoriconazoleThe metabolism of Estrogens, esterified can be decreased when combined with Voriconazole.Approved, Investigational
WarfarinEstrogens, esterified may decrease the anticoagulant activities of Warfarin.Approved
XimelagatranThe serum concentration of Estrogens, esterified can be decreased when it is combined with Ximelagatran.Approved, Investigational, Withdrawn
Z-Val-Ala-Asp fluoromethyl ketoneThe serum concentration of Estrogens, esterified can be decreased when it is combined with Z-Val-Ala-Asp fluoromethyl ketone.Experimental
ZiprasidoneThe metabolism of Estrogens, esterified can be decreased when combined with Ziprasidone.Approved
ZofenoprilThe serum concentration of Estrogens, esterified can be decreased when it is combined with Zofenopril.Experimental
Food Interactions
Not Available

References

Synthesis Reference
Not Available
General References
  1. MSDS [Link]
  2. product info [Link]
  3. product info [Link]
  4. article [Link]
External Links
Not Available
ATC Codes
Not Available
AHFS Codes
Not Available
PDB Entries
Not Available
FDA label
Not Available
MSDS
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentHot Flushes, Menopause, Postmenopause1
2CompletedTreatmentMenopause1
2TerminatedTreatmentCancer, Breast1
2TerminatedTreatmentMenopause2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Tablet, coatedOral
TabletOral
TabletOral0.3 mg
TabletOral0.625 mg
TabletOral.3 mg/1
TabletOral.625 mg/1
TabletOral1.25 mg/1
Tablet, film coatedOral.3 mg/1
Tablet, film coatedOral.625 mg/1
Tablet, film coatedOral1.25 mg/1
Tablet, film coatedOral2.5 mg/1
TabletOral1.25 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da

Drug created on November 30, 2015 12:10 / Updated on March 08, 2017 10:58