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IdentificationPharmacologyInteractionsReferencesTrialsEconomicsPropertiesSpectraTaxonomyEstrogens, esterified
Identification
- Name
- Estrogens, esterified
- Accession Number
- DB09381
- Type
- Small Molecule
- Groups
- Approved
- Description
Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of menopause such as hot flashes, vaginal dryness, vaginal burning or irritation, or other hormonal changes in the vagina. It is being also for the prevention and treatment of osteoporosis.
- Structure
- Synonyms
- Esterified Estrogens
- Estrogens, Esterified Component of Menrium
- Estrogens,esterified
- Menrium Component Estrogens, Esterified
- Product Images
- Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Estragyn Tablet 0.625 mg Oral Searchlight Pharma Inc 1974-12-31 Not applicable Canada 
Estragyn Tablet 0.3 mg Oral Searchlight Pharma Inc 1980-12-31 Not applicable Canada Neo Estrone Tab 1.25mg Tablet 1.25 mg Oral Neolab Inc 1974-12-31 2008-04-02 Canada - Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Menest Tablet .625 mg/1 Oral Physicians Total Care, Inc. 2008-09-05 Not applicable US 
Menest Tablet, film coated .625 mg/1 Oral Avera Mc Kennan Hospital 2015-11-23 Not applicable US Menest Tablet, film coated .625 mg/1 Oral Pfizer Laboratories Div Pfizer Inc. 1977-09-28 Not applicable US Menest Tablet .3 mg/1 Oral Physicians Total Care, Inc. 2010-12-09 Not applicable US Menest Tablet, film coated 2.5 mg/1 Oral Pfizer Laboratories Div Pfizer Inc. 1977-09-28 2017-10-18 US Menest Tablet, film coated 1.25 mg/1 Oral Pfizer Laboratories Div Pfizer Inc. 1977-09-28 Not applicable US Menest Tablet 1.25 mg/1 Oral Physicians Total Care, Inc. 2010-12-16 Not applicable US Menest Tablet, film coated .3 mg/1 Oral Pfizer Laboratories Div Pfizer Inc. 1977-09-28 Not applicable US - International/Other Brands
- Amnestrogen / Estratab / Evex / Femogen
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Covaryx Estrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1) Tablet, coated Oral Centrix Pharmaceutical 2007-04-01 Not applicable US 
Covaryx Hs Estrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1) Tablet, coated Oral Centrix Pharmaceutical 2007-04-01 Not applicable US Eemt Estrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1) Tablet, coated Oral Creekwood Pharmaceuticals, Inc. 2011-09-01 Not applicable US Eemt Hs Estrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1) Tablet, coated Oral Creekwood Pharmaceuticals, Inc. 2011-09-01 Not applicable US Esterified Estrogens and Methyltestosterone Estrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1) Tablet Oral Method Pharmaceuticals 2017-08-15 Not applicable US Esterified Estrogens and Methyltestosterone Estrogens, esterified (1.25 mg/1) + Methyltestosterone (2.5 mg/1) Tablet Oral ANIP Acquisition Company 2010-12-22 Not applicable US Esterified Estrogens and Methyltestosterone Estrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1) Tablet Oral Method Pharmaceuticals 2017-08-15 Not applicable US Esterified Estrogens and Methyltestosterone Estrogens, esterified (.625 mg/1) + Methyltestosterone (1.25 mg/1) Tablet Oral ANIP Acquisition Company 2010-12-22 Not applicable US - Categories
- UNII
- 3ASP8Q3768
- CAS number
- Not Available
- Weight
- Not Available
- Chemical Formula
- Not Available
- InChI Key
- Not Available
- InChI
- Not Available
- IUPAC Name
- Not Available
- SMILES
- Not Available
Pharmacology
- Indication
Esterified estrogens are indicated to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. It is also indicated for the treatment of symptoms of breast cancer in both men and women. In men it can be used for the treatment of advanced prostate cancer. It is also indicated for the treatment of menopausal symptoms.
- Structured Indications
- Pharmacodynamics
Estrogens are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Estradiol is the principle intracellular human estrogen and is more potent than estrone and estriol at the receptor level; it is the primary estrogen secreted prior to menopause.
- Mechanism of action
Estrogens modulate the pituitary secretion of gonadotropins, luteinizing hormone, and follicle-stimulating hormone through a negative feedback system; estrogen replacement reduces elevated levels of these hormones.
- Absorption
Readily absorbed after oral administration. High concentrations of estrone are achieved with oral administration, whereas higher concentrations of estradiol are generally achieved after percutaneous absorption. Although vaginal products (such as gel, rings, etc.) are administered locally, they achieve high serum concentrations.
- Volume of distribution
The distribution of exogenous estrogens is similar to that of endogenous estrogens. Estrogens are widely distributed in the body and are generally found in higher concentration in the sex hormone target organs.
- Protein binding
Approximately 95-98% of estradiol is bound loosely to albumin or tightly to sex hormone binding globulin.
- Metabolism
Hepatic; partial metabolism via CYP3A4 enzymes; estradiol is reversibly converted to estrone and estriol; oral estradiol also undergoes enterohepatic recirculation by conjugation in the liver, followed by excretion of sulfate and glucuronide conjugates into the bile, then hydrolysis in the intestine and estrogen reabsorption. Sulfate conjugates are the primary form found in postmenopausal women.
- Route of elimination
Mainly urinary as estradiol, estrone, estriol, and their glucuronide and sulfate conjugates.
- Half life
Half-life varies, it is in the range 1-2 hr.
- Clearance
There is variation in the clearance rate depends on each estrogen individual: estradiol-17β: 580 L/day/m2 estrone: 4050 L/day/m2 estriol: 1110 L/day/m2
- Toxicity
LD50 IP 325 mg/Kg (rat). LD50 IV 1740 mg/Kg (mouse). LD50 oral >5000 mg/Kg (rat).
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
Drug Interaction Drug group 1,10-Phenanthroline The serum concentration of Estrogens, esterified can be decreased when it is combined with 1,10-Phenanthroline. Experimental 3,4-Dichloroisocoumarin The serum concentration of Estrogens, esterified can be decreased when it is combined with 3,4-Dichloroisocoumarin. Experimental 4-(2-Aminoethyl)Benzenesulfonyl Fluoride The serum concentration of Estrogens, esterified can be decreased when it is combined with 4-(2-Aminoethyl)Benzenesulfonyl Fluoride. Experimental Acenocoumarol Estrogens, esterified may decrease the anticoagulant activities of Acenocoumarol. Approved Acitretin The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Acitretin. Approved Adapalene The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Adapalene. Approved Alitretinoin The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Alitretinoin. Approved, Investigational Alogliptin The serum concentration of Estrogens, esterified can be decreased when it is combined with Alogliptin. Approved Alpha-1-proteinase inhibitor The serum concentration of Estrogens, esterified can be decreased when it is combined with Alpha-1-proteinase inhibitor. Approved Amiodarone The metabolism of Estrogens, esterified can be decreased when combined with Amiodarone. Approved, Investigational Amobarbital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Amobarbital. Approved, Illicit Amprenavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Amprenavir. Approved Antithrombin III human The serum concentration of Estrogens, esterified can be decreased when it is combined with Antithrombin III human. Approved Apixaban The serum concentration of Estrogens, esterified can be decreased when it is combined with Apixaban. Approved Aprepitant The serum concentration of Estrogens, esterified can be decreased when it is combined with Aprepitant. Approved, Investigational Aprotinin The serum concentration of Estrogens, esterified can be decreased when it is combined with Aprotinin. Approved, Withdrawn Argatroban The serum concentration of Estrogens, esterified can be decreased when it is combined with Argatroban. Approved, Investigational Armodafinil The serum concentration of Estrogens, esterified can be decreased when it is combined with Armodafinil. Approved, Investigational Artemether The serum concentration of Estrogens, esterified can be decreased when it is combined with Artemether. Approved Asunaprevir The serum concentration of Estrogens, esterified can be decreased when it is combined with Asunaprevir. Approved, Investigational Atazanavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Atazanavir. Approved, Investigational Atomoxetine The metabolism of Estrogens, esterified can be decreased when combined with Atomoxetine. Approved Barbexaclone The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Barbexaclone. Experimental Barbital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Barbital. Illicit Batimastat The serum concentration of Estrogens, esterified can be decreased when it is combined with Batimastat. Experimental Benazepril The serum concentration of Estrogens, esterified can be decreased when it is combined with Benazepril. Approved, Investigational Benzamidine The serum concentration of Estrogens, esterified can be decreased when it is combined with Benzamidine. Experimental Bexarotene The serum concentration of Estrogens, esterified can be decreased when it is combined with Bexarotene. Approved, Investigational Bivalirudin The serum concentration of Estrogens, esterified can be decreased when it is combined with Bivalirudin. Approved, Investigational Boceprevir The serum concentration of Estrogens, esterified can be decreased when it is combined with Boceprevir. Withdrawn Bortezomib The metabolism of Estrogens, esterified can be decreased when combined with Bortezomib. Approved, Investigational Bosentan The serum concentration of Estrogens, esterified can be decreased when it is combined with Bosentan. Approved, Investigational Camostat The serum concentration of Estrogens, esterified can be decreased when it is combined with Camostat. Experimental Candoxatril The serum concentration of Estrogens, esterified can be decreased when it is combined with Candoxatril. Experimental Candoxatrilat The serum concentration of Estrogens, esterified can be decreased when it is combined with Candoxatrilat. Experimental Captopril The serum concentration of Estrogens, esterified can be decreased when it is combined with Captopril. Approved Carbamazepine The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Carbamazepine. Approved, Investigational Ceritinib The serum concentration of Estrogens, esterified can be increased when it is combined with Ceritinib. Approved Cholesterol The serum concentration of Estrogens, esterified can be decreased when it is combined with Cholesterol. Experimental Cholestyramine The serum concentration of Estrogens, esterified can be decreased when it is combined with Cholestyramine. Approved Chymostatin The serum concentration of Estrogens, esterified can be decreased when it is combined with Chymostatin. Experimental Cilastatin The serum concentration of Estrogens, esterified can be decreased when it is combined with Cilastatin. Approved Cilazapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Cilazapril. Approved Clarithromycin The metabolism of Estrogens, esterified can be decreased when combined with Clarithromycin. Approved Clemastine The metabolism of Estrogens, esterified can be decreased when combined with Clemastine. Approved Clobazam The serum concentration of Estrogens, esterified can be decreased when it is combined with Clobazam. Approved, Illicit Clorindione Estrogens, esterified may decrease the anticoagulant activities of Clorindione. Experimental Clotrimazole The metabolism of Estrogens, esterified can be decreased when combined with Clotrimazole. Approved, Vet Approved Cobicistat The serum concentration of Estrogens, esterified can be decreased when it is combined with Cobicistat. Approved Colesevelam The serum concentration of Estrogens, esterified can be decreased when it is combined with Colesevelam. Approved Colestipol The serum concentration of Estrogens, esterified can be decreased when it is combined with Colestipol. Approved Conivaptan The serum concentration of Estrogens, esterified can be increased when it is combined with Conivaptan. Approved, Investigational Crizotinib The metabolism of Estrogens, esterified can be decreased when combined with Crizotinib. Approved Cyclosporine The metabolism of Estrogens, esterified can be decreased when combined with Cyclosporine. Approved, Investigational, Vet Approved Dabigatran etexilate The serum concentration of Estrogens, esterified can be decreased when it is combined with Dabigatran etexilate. Approved Dabrafenib The serum concentration of Estrogens, esterified can be decreased when it is combined with Dabrafenib. Approved Darexaban The serum concentration of Estrogens, esterified can be decreased when it is combined with Darexaban. Investigational Darunavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Darunavir. Approved Dasatinib The serum concentration of Estrogens, esterified can be increased when it is combined with Dasatinib. Approved, Investigational Deferasirox The serum concentration of Estrogens, esterified can be decreased when it is combined with Deferasirox. Approved, Investigational Delanzomib The serum concentration of Estrogens, esterified can be decreased when it is combined with Delanzomib. Investigational Delapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Delapril. Experimental Delavirdine The metabolism of Estrogens, esterified can be decreased when combined with Delavirdine. Approved Dicoumarol Estrogens, esterified may decrease the anticoagulant activities of Dicoumarol. Approved Dihydroergotamine The metabolism of Estrogens, esterified can be decreased when combined with Dihydroergotamine. Approved Diltiazem The metabolism of Estrogens, esterified can be decreased when combined with Diltiazem. Approved Diphenadione Estrogens, esterified may decrease the anticoagulant activities of Diphenadione. Experimental Doxycycline The metabolism of Estrogens, esterified can be decreased when combined with Doxycycline. Approved, Investigational, Vet Approved Dronedarone The metabolism of Estrogens, esterified can be decreased when combined with Dronedarone. Approved Ecabet The serum concentration of Estrogens, esterified can be decreased when it is combined with Ecabet. Approved, Investigational Edoxaban The serum concentration of Estrogens, esterified can be decreased when it is combined with Edoxaban. Approved Elafin The serum concentration of Estrogens, esterified can be decreased when it is combined with Elafin. Investigational Elvitegravir The serum concentration of Estrogens, esterified can be decreased when it is combined with Elvitegravir. Approved Enalapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Enalapril. Approved, Vet Approved Enalaprilat The serum concentration of Estrogens, esterified can be decreased when it is combined with Enalaprilat. Approved Enalkiren The serum concentration of Estrogens, esterified can be decreased when it is combined with Enalkiren. Experimental Enzalutamide The serum concentration of Estrogens, esterified can be decreased when it is combined with Enzalutamide. Approved Epigallocatechin Gallate The serum concentration of Estrogens, esterified can be decreased when it is combined with Epigallocatechin Gallate. Investigational Erythromycin The metabolism of Estrogens, esterified can be decreased when combined with Erythromycin. Approved, Vet Approved Eslicarbazepine acetate The serum concentration of Estrogens, esterified can be decreased when it is combined with Eslicarbazepine acetate. Approved Ethyl biscoumacetate Estrogens, esterified may decrease the anticoagulant activities of Ethyl biscoumacetate. Withdrawn Exenatide The serum concentration of Estrogens, esterified can be decreased when it is combined with Exenatide. Approved, Investigational Faldaprevir The serum concentration of Estrogens, esterified can be decreased when it is combined with Faldaprevir. Investigational Felbamate The serum concentration of Estrogens, esterified can be decreased when it is combined with Felbamate. Approved Flibanserin The serum concentration of Flibanserin can be increased when it is combined with Estrogens, esterified. Approved Fluconazole The metabolism of Estrogens, esterified can be decreased when combined with Fluconazole. Approved Fluindione Estrogens, esterified may decrease the anticoagulant activities of Fluindione. Investigational Fluvoxamine The metabolism of Estrogens, esterified can be decreased when combined with Fluvoxamine. Approved, Investigational Fosamprenavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Fosamprenavir. Approved Fosaprepitant The serum concentration of Estrogens, esterified can be decreased when it is combined with Fosaprepitant. Approved Fosinopril The serum concentration of Estrogens, esterified can be decreased when it is combined with Fosinopril. Approved Fosphenytoin The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Fosphenytoin. Approved Fusidic Acid The serum concentration of Estrogens, esterified can be increased when it is combined with Fusidic Acid. Approved Gabexate The serum concentration of Estrogens, esterified can be decreased when it is combined with Gabexate. Investigational Geldanamycin The serum concentration of Estrogens, esterified can be decreased when it is combined with Geldanamycin. Experimental GM6001 The serum concentration of Estrogens, esterified can be decreased when it is combined with GM6001. Experimental Griseofulvin The metabolism of Estrogens, esterified can be increased when combined with Griseofulvin. Approved, Vet Approved Hexobarbital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Hexobarbital. Approved Idelalisib The serum concentration of Estrogens, esterified can be increased when it is combined with Idelalisib. Approved Idraparinux The serum concentration of Estrogens, esterified can be decreased when it is combined with Idraparinux. Investigational Imatinib The metabolism of Estrogens, esterified can be decreased when combined with Imatinib. Approved Imidapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Imidapril. Investigational Indinavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Indinavir. Approved Isavuconazonium The metabolism of Estrogens, esterified can be decreased when combined with Isavuconazonium. Approved, Investigational Isoflurophate The serum concentration of Estrogens, esterified can be decreased when it is combined with Isoflurophate. Approved, Withdrawn Isotretinoin The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Isotretinoin. Approved Isradipine The metabolism of Estrogens, esterified can be decreased when combined with Isradipine. Approved Itraconazole The metabolism of Estrogens, esterified can be decreased when combined with Itraconazole. Approved, Investigational Ivacaftor The serum concentration of Estrogens, esterified can be increased when it is combined with Ivacaftor. Approved Ixazomib The serum concentration of Estrogens, esterified can be decreased when it is combined with Ixazomib. Approved Ketoconazole The metabolism of Estrogens, esterified can be decreased when combined with Ketoconazole. Approved, Investigational Lamotrigine The serum concentration of Lamotrigine can be decreased when it is combined with Estrogens, esterified. Approved, Investigational Lepirudin The serum concentration of Estrogens, esterified can be decreased when it is combined with Lepirudin. Approved Letaxaban The serum concentration of Estrogens, esterified can be decreased when it is combined with Letaxaban. Investigational Linagliptin The serum concentration of Estrogens, esterified can be decreased when it is combined with Linagliptin. Approved Lisinopril The serum concentration of Estrogens, esterified can be decreased when it is combined with Lisinopril. Approved, Investigational Lopinavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Lopinavir. Approved Lovastatin The metabolism of Estrogens, esterified can be decreased when combined with Lovastatin. Approved, Investigational Luliconazole The serum concentration of Estrogens, esterified can be increased when it is combined with Luliconazole. Approved Lumacaftor The serum concentration of Estrogens, esterified can be decreased when it is combined with Lumacaftor. Approved Melagatran The serum concentration of Estrogens, esterified can be decreased when it is combined with Melagatran. Experimental Methohexital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Methohexital. Approved Methylphenobarbital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Methylphenobarbital. Approved Metreleptin The serum concentration of Estrogens, esterified can be decreased when it is combined with Metreleptin. Approved Mifepristone The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Mifepristone. Approved, Investigational Mitotane The serum concentration of Estrogens, esterified can be decreased when it is combined with Mitotane. Approved Modafinil The serum concentration of Estrogens, esterified can be decreased when it is combined with Modafinil. Approved, Investigational Moexipril The serum concentration of Estrogens, esterified can be decreased when it is combined with Moexipril. Approved Mycophenolic acid The serum concentration of Estrogens, esterified can be decreased when it is combined with Mycophenolic acid. Approved N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline The serum concentration of Estrogens, esterified can be decreased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline. Experimental Nafamostat The serum concentration of Estrogens, esterified can be decreased when it is combined with Nafamostat. Approved, Investigational Nafcillin The metabolism of Estrogens, esterified can be increased when combined with Nafcillin. Approved Nefazodone The metabolism of Estrogens, esterified can be decreased when combined with Nefazodone. Approved, Withdrawn Nelfinavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Nelfinavir. Approved Netupitant The serum concentration of Estrogens, esterified can be increased when it is combined with Netupitant. Approved Nevirapine The serum concentration of Estrogens, esterified can be decreased when it is combined with Nevirapine. Approved Nilotinib The metabolism of Estrogens, esterified can be decreased when combined with Nilotinib. Approved, Investigational Nitroaspirin The serum concentration of Estrogens, esterified can be decreased when it is combined with Nitroaspirin. Investigational Olaparib The metabolism of Estrogens, esterified can be decreased when combined with Olaparib. Approved Omapatrilat The serum concentration of Estrogens, esterified can be decreased when it is combined with Omapatrilat. Investigational Osimertinib The serum concentration of Estrogens, esterified can be increased when it is combined with Osimertinib. Approved Otamixaban The serum concentration of Estrogens, esterified can be decreased when it is combined with Otamixaban. Investigational Oxcarbazepine The serum concentration of Estrogens, esterified can be decreased when it is combined with Oxcarbazepine. Approved Palbociclib The serum concentration of Estrogens, esterified can be increased when it is combined with Palbociclib. Approved Pentobarbital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Pentobarbital. Approved, Vet Approved Perindopril The serum concentration of Estrogens, esterified can be decreased when it is combined with Perindopril. Approved Phenindione Estrogens, esterified may decrease the anticoagulant activities of Phenindione. Approved Phenobarbital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Phenobarbital. Approved Phenprocoumon Estrogens, esterified may decrease the anticoagulant activities of Phenprocoumon. Approved Phenytoin The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Phenytoin. Approved, Vet Approved Phosphoramidon The serum concentration of Estrogens, esterified can be decreased when it is combined with Phosphoramidon. Experimental Posaconazole The metabolism of Estrogens, esterified can be decreased when combined with Posaconazole. Approved, Investigational, Vet Approved Primidone The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Primidone. Approved, Vet Approved Prinomastat The serum concentration of Estrogens, esterified can be decreased when it is combined with Prinomastat. Investigational Prucalopride The serum concentration of Estrogens, esterified can be decreased when it is combined with Prucalopride. Approved Quinapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Quinapril. Approved, Investigational Racecadotril The serum concentration of Estrogens, esterified can be decreased when it is combined with Racecadotril. Investigational Ramipril The serum concentration of Estrogens, esterified can be decreased when it is combined with Ramipril. Approved Ranolazine The metabolism of Estrogens, esterified can be decreased when combined with Ranolazine. Approved, Investigational Remikiren The serum concentration of Estrogens, esterified can be decreased when it is combined with Remikiren. Approved Rifabutin The serum concentration of Estrogens, esterified can be decreased when it is combined with Rifabutin. Approved Rifampicin The serum concentration of Estrogens, esterified can be decreased when it is combined with Rifampicin. Approved Rifapentine The serum concentration of Estrogens, esterified can be decreased when it is combined with Rifapentine. Approved Ritonavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Ritonavir. Approved, Investigational Rivaroxaban The serum concentration of Estrogens, esterified can be decreased when it is combined with Rivaroxaban. Approved S-3304 The serum concentration of Estrogens, esterified can be decreased when it is combined with S-3304. Investigational Saquinavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Saquinavir. Approved, Investigational Saxagliptin The serum concentration of Estrogens, esterified can be decreased when it is combined with Saxagliptin. Approved Secobarbital The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Secobarbital. Approved, Vet Approved Selegiline The serum concentration of Selegiline can be increased when it is combined with Estrogens, esterified. Approved, Investigational, Vet Approved Sildenafil The metabolism of Estrogens, esterified can be decreased when combined with Sildenafil. Approved, Investigational Siltuximab The serum concentration of Estrogens, esterified can be decreased when it is combined with Siltuximab. Approved Simeprevir The serum concentration of Estrogens, esterified can be increased when it is combined with Simeprevir. Approved Sitagliptin The serum concentration of Estrogens, esterified can be decreased when it is combined with Sitagliptin. Approved, Investigational Sivelestat The serum concentration of Estrogens, esterified can be decreased when it is combined with Sivelestat. Investigational Spirapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Spirapril. Approved St. John's Wort The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with St. John's Wort. Nutraceutical Stiripentol The serum concentration of Estrogens, esterified can be increased when it is combined with Stiripentol. Approved Sulfisoxazole The metabolism of Estrogens, esterified can be decreased when combined with Sulfisoxazole. Approved, Vet Approved Telaprevir The serum concentration of Estrogens, esterified can be decreased when it is combined with Telaprevir. Withdrawn Telithromycin The metabolism of Estrogens, esterified can be decreased when combined with Telithromycin. Approved Temocapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Temocapril. Experimental, Investigational Thalidomide Estrogens, esterified may increase the thrombogenic activities of Thalidomide. Approved, Investigational, Withdrawn Thiamylal The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Thiamylal. Approved, Vet Approved Thiopental The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Thiopental. Approved, Vet Approved Thiorphan The serum concentration of Estrogens, esterified can be decreased when it is combined with Thiorphan. Experimental Ticlopidine The metabolism of Estrogens, esterified can be decreased when combined with Ticlopidine. Approved Tioclomarol Estrogens, esterified may decrease the anticoagulant activities of Tioclomarol. Experimental Tipranavir The serum concentration of Estrogens, esterified can be decreased when it is combined with Tipranavir. Approved, Investigational Tocilizumab The serum concentration of Estrogens, esterified can be decreased when it is combined with Tocilizumab. Approved Topiramate The serum concentration of Estrogens, esterified can be decreased when it is combined with Topiramate. Approved Trandolapril The serum concentration of Estrogens, esterified can be decreased when it is combined with Trandolapril. Approved Tranexamic Acid Estrogens, esterified may increase the thrombogenic activities of Tranexamic Acid. Approved Tretinoin The therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Tretinoin. Approved, Investigational, Nutraceutical Ubenimex The serum concentration of Estrogens, esterified can be decreased when it is combined with Ubenimex. Experimental Ulinastatin The serum concentration of Estrogens, esterified can be decreased when it is combined with Ulinastatin. Investigational Venlafaxine The metabolism of Estrogens, esterified can be decreased when combined with Venlafaxine. Approved Verapamil The metabolism of Estrogens, esterified can be decreased when combined with Verapamil. Approved Vildagliptin The serum concentration of Estrogens, esterified can be decreased when it is combined with Vildagliptin. Approved, Investigational Voriconazole The metabolism of Estrogens, esterified can be decreased when combined with Voriconazole. Approved, Investigational Warfarin Estrogens, esterified may decrease the anticoagulant activities of Warfarin. Approved Ximelagatran The serum concentration of Estrogens, esterified can be decreased when it is combined with Ximelagatran. Approved, Investigational, Withdrawn Z-Val-Ala-Asp fluoromethyl ketone The serum concentration of Estrogens, esterified can be decreased when it is combined with Z-Val-Ala-Asp fluoromethyl ketone. Experimental Ziprasidone The metabolism of Estrogens, esterified can be decreased when combined with Ziprasidone. Approved Zofenopril The serum concentration of Estrogens, esterified can be decreased when it is combined with Zofenopril. Experimental - Food Interactions
- Not Available
References
- Synthesis Reference
- Not Available
- General References
- External Links
- Not Available
- ATC Codes
- Not Available
- AHFS Codes
- Not Available
- PDB Entries
- Not Available
- FDA label
- Not Available
- MSDS
- Not Available
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Hot Flushes, Menopause, Postmenopause 1 2 Completed Treatment Menopause 1 2 Terminated Treatment Cancer, Breast 1 2 Terminated Treatment Menopause 2
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage forms
Form Route Strength Tablet, coated Oral Tablet Oral Tablet Oral 0.3 mg Tablet Oral 0.625 mg Tablet Oral .3 mg/1 Tablet Oral .625 mg/1 Tablet Oral 1.25 mg/1 Tablet, film coated Oral .3 mg/1 Tablet, film coated Oral .625 mg/1 Tablet, film coated Oral 1.25 mg/1 Tablet, film coated Oral 2.5 mg/1 Tablet Oral 1.25 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
- Not Available
- Predicted ADMET features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Taxonomy
- Classification
- Not classified
Enzymes
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- CYP3A4
- Uniprot ID
- P08684
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
Drug created on November 30, 2015 12:10 / Updated on March 08, 2017 10:58