Semapimod

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Semapimod
Accession Number
DB12094
Type
Small Molecule
Groups
Investigational
Description

Semapimod has been used in trials studying the treatment of Crohn Disease.

Structure
Thumb
Synonyms
Not Available
External IDs
CPSI-2364 FREE BASE
Product Ingredients
IngredientUNIICASInChI Key
Semapimod Mesylate8W415THB21872830-80-3CKWNYVLFZNKVGX-RTQZJKMDSA-N
Semapimod TetrahydrochlorideA16WYQ522A164301-51-3MAHASPGBAIQZLY-RTQZJKMDSA-N
Categories
UNII
9SGW2H1K8P
CAS number
352513-83-8
Weight
Average: 744.914
Monoisotopic: 744.452062986
Chemical Formula
C34H52N18O2
InChI Key
PWDYHMBTPGXCSN-VCBMUGGBSA-N
InChI
InChI=1S/C34H52N18O2/c1-19(45-49-31(35)36)23-13-24(20(2)46-50-32(37)38)16-27(15-23)43-29(53)11-9-7-5-6-8-10-12-30(54)44-28-17-25(21(3)47-51-33(39)40)14-26(18-28)22(4)48-52-34(41)42/h13-18H,5-12H2,1-4H3,(H,43,53)(H,44,54)(H4,35,36,49)(H4,37,38,50)(H4,39,40,51)(H4,41,42,52)/b45-19+,46-20+,47-21+,48-22+
IUPAC Name
N,N'-bis({3,5-bis[(1E)-1-(carbamimidamidoimino)ethyl]phenyl})decanediamide
SMILES
C\C(=N/NC(N)=N)C1=CC(=CC(NC(=O)CCCCCCCCC(=O)NC2=CC(=CC(=C2)C(\C)=N\NC(N)=N)C(\C)=N\NC(N)=N)=C1)C(\C)=N\NC(N)=N

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limoneneThe risk or severity of adverse effects can be increased when (4R)-limonene is combined with Semapimod.Investigational
16-BromoepiandrosteroneThe risk or severity of adverse effects can be increased when Semapimod is combined with 16-Bromoepiandrosterone.Investigational
19-norandrostenedioneThe risk or severity of adverse effects can be increased when Semapimod is combined with 19-norandrostenedione.Experimental, Illicit
5-androstenedioneThe risk or severity of adverse effects can be increased when Semapimod is combined with 5-androstenedione.Experimental, Illicit
AcebutololSemapimod may decrease the antihypertensive activities of Acebutolol.Approved, Investigational
AceclofenacThe risk or severity of adverse effects can be increased when Semapimod is combined with Aceclofenac.Approved, Investigational
AcemetacinThe risk or severity of adverse effects can be increased when Semapimod is combined with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolSemapimod may increase the anticoagulant activities of Acenocoumarol.Approved, Investigational
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Semapimod is combined with Acetylsalicylic acid.Approved, Vet Approved
AdapaleneThe risk or severity of adverse effects can be increased when Adapalene is combined with Semapimod.Approved
AlclofenacThe risk or severity of adverse effects can be increased when Semapimod is combined with Alclofenac.Approved, Withdrawn
AlclometasoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Alclometasone.Approved
AldosteroneThe risk or severity of adverse effects can be increased when Semapimod is combined with Aldosterone.Experimental, Investigational
Alendronic acidThe risk or severity of adverse effects can be increased when Semapimod is combined with Alendronic acid.Approved
AliskirenSemapimod may decrease the antihypertensive activities of Aliskiren.Approved, Investigational
AlminoprofenThe risk or severity of adverse effects can be increased when Semapimod is combined with Alminoprofen.Experimental
AlprenololSemapimod may decrease the antihypertensive activities of Alprenolol.Approved, Withdrawn
AlprostadilThe therapeutic efficacy of Alprostadil can be decreased when used in combination with Semapimod.Approved, Investigational
AmcinonideThe risk or severity of adverse effects can be increased when Semapimod is combined with Amcinonide.Approved
AmilorideSemapimod may decrease the antihypertensive activities of Amiloride.Approved
Aminosalicylic AcidThe risk or severity of adverse effects can be increased when Semapimod is combined with Aminosalicylic Acid.Approved
AncrodSemapimod may increase the anticoagulant activities of Ancrod.Approved, Investigational
AndrographolideThe risk or severity of adverse effects can be increased when Andrographolide is combined with Semapimod.Investigational
AndrostenedioneThe risk or severity of adverse effects can be increased when Semapimod is combined with Androstenedione.Experimental, Illicit
AnecortaveThe risk or severity of adverse effects can be increased when Semapimod is combined with Anecortave.Investigational
anecortave acetateThe risk or severity of adverse effects can be increased when Semapimod is combined with anecortave acetate.Investigational
AnisodamineThe risk or severity of adverse effects can be increased when Anisodamine is combined with Semapimod.Investigational
Anthrax immune globulin humanThe risk or severity of adverse effects can be increased when Semapimod is combined with Anthrax immune globulin human.Approved
AntipyrineThe risk or severity of adverse effects can be increased when Semapimod is combined with Antipyrine.Approved, Investigational
Antithrombin III humanSemapimod may increase the anticoagulant activities of Antithrombin III human.Approved
AntrafenineThe risk or severity of adverse effects can be increased when Semapimod is combined with Antrafenine.Approved
ApixabanSemapimod may increase the anticoagulant activities of Apixaban.Approved
ApocyninThe risk or severity of adverse effects can be increased when Semapimod is combined with Apocynin.Investigational
ApramycinSemapimod may decrease the excretion rate of Apramycin which could result in a higher serum level.Experimental, Vet Approved
ApremilastThe risk or severity of adverse effects can be increased when Apremilast is combined with Semapimod.Approved, Investigational
ArbekacinSemapimod may decrease the excretion rate of Arbekacin which could result in a higher serum level.Approved, Investigational
ArdeparinSemapimod may increase the anticoagulant activities of Ardeparin.Approved, Investigational, Withdrawn
ArgatrobanSemapimod may increase the anticoagulant activities of Argatroban.Approved, Investigational
ArotinololSemapimod may decrease the antihypertensive activities of Arotinolol.Investigational
AsenapineSemapimod may decrease the antihypertensive activities of Asenapine.Approved
AtamestaneThe risk or severity of adverse effects can be increased when Semapimod is combined with Atamestane.Investigational
AtenololSemapimod may decrease the antihypertensive activities of Atenolol.Approved
AzapropazoneThe risk or severity of adverse effects can be increased when Azapropazone is combined with Semapimod.Withdrawn
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Semapimod.Approved
Azficel-TThe risk or severity of adverse effects can be increased when Semapimod is combined with Azficel-T.Approved, Investigational
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Azilsartan medoxomil is combined with Semapimod.Approved, Investigational
AzosemideThe therapeutic efficacy of Azosemide can be decreased when used in combination with Semapimod.Investigational
Bacillus calmette-guerin substrain connaught live antigenThe risk or severity of adverse effects can be increased when Semapimod is combined with Bacillus calmette-guerin substrain connaught live antigen.Approved, Investigational
Bacillus calmette-guerin substrain tice live antigenThe risk or severity of adverse effects can be increased when Semapimod is combined with Bacillus calmette-guerin substrain tice live antigen.Approved
BalsalazideThe risk or severity of adverse effects can be increased when Semapimod is combined with Balsalazide.Approved, Investigational
BCG vaccineThe therapeutic efficacy of BCG vaccine can be decreased when used in combination with Semapimod.Investigational
BecaplerminSemapimod may increase the anticoagulant activities of Becaplermin.Approved, Investigational
BefunololSemapimod may decrease the antihypertensive activities of Befunolol.Experimental
BekanamycinSemapimod may decrease the excretion rate of Bekanamycin which could result in a higher serum level.Experimental
BenazeprilThe risk or severity of adverse effects can be increased when Semapimod is combined with Benazepril.Approved, Investigational
BendazacThe risk or severity of adverse effects can be increased when Semapimod is combined with Bendazac.Experimental
BendroflumethiazideThe therapeutic efficacy of Bendroflumethiazide can be decreased when used in combination with Semapimod.Approved
BenorilateThe risk or severity of adverse effects can be increased when Semapimod is combined with Benorilate.Experimental
BenoxaprofenThe risk or severity of adverse effects can be increased when Benoxaprofen is combined with Semapimod.Withdrawn
BenzthiazideThe therapeutic efficacy of Benzthiazide can be decreased when used in combination with Semapimod.Approved
BenzydamineThe risk or severity of adverse effects can be increased when Semapimod is combined with Benzydamine.Approved
BeraprostThe therapeutic efficacy of Beraprost can be decreased when used in combination with Semapimod.Investigational
BetamethasoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Betamethasone.Approved, Vet Approved
BetaxololSemapimod may decrease the antihypertensive activities of Betaxolol.Approved, Investigational
BetrixabanThe risk or severity of bleeding can be increased when Betrixaban is combined with Semapimod.Approved, Investigational
BevantololSemapimod may decrease the antihypertensive activities of Bevantolol.Approved
BevoniumThe risk or severity of adverse effects can be increased when Semapimod is combined with Bevonium.Experimental
BimatoprostThe therapeutic efficacy of Bimatoprost can be decreased when used in combination with Semapimod.Approved, Investigational
BisoprololSemapimod may decrease the antihypertensive activities of Bisoprolol.Approved
BopindololSemapimod may decrease the antihypertensive activities of Bopindolol.Approved
BromfenacThe risk or severity of adverse effects can be increased when Semapimod is combined with Bromfenac.Approved
BucillamineThe risk or severity of adverse effects can be increased when Semapimod is combined with Bucillamine.Investigational
BucindololSemapimod may decrease the antihypertensive activities of Bucindolol.Investigational
BufexamacThe risk or severity of adverse effects can be increased when Semapimod is combined with Bufexamac.Approved, Experimental
BufuralolSemapimod may decrease the antihypertensive activities of Bufuralol.Experimental, Investigational
BumadizoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Bumadizone.Experimental
BumetanideThe therapeutic efficacy of Bumetanide can be decreased when used in combination with Semapimod.Approved
BupranololSemapimod may decrease the antihypertensive activities of Bupranolol.Approved
CandesartanThe risk or severity of adverse effects can be increased when Candesartan is combined with Semapimod.Experimental
Candesartan cilexetilThe risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Semapimod.Approved
CandoxatrilThe risk or severity of adverse effects can be increased when Semapimod is combined with Candoxatril.Experimental
CapsaicinThe risk or severity of adverse effects can be increased when Semapimod is combined with Capsaicin.Approved
CaptoprilThe risk or severity of adverse effects can be increased when Semapimod is combined with Captopril.Approved
Carbaspirin calciumThe risk or severity of adverse effects can be increased when Semapimod is combined with Carbaspirin calcium.Experimental, Investigational
Carboprost TromethamineThe therapeutic efficacy of Carboprost Tromethamine can be decreased when used in combination with Semapimod.Approved
CarprofenThe risk or severity of adverse effects can be increased when Semapimod is combined with Carprofen.Approved, Vet Approved, Withdrawn
CarteololSemapimod may decrease the antihypertensive activities of Carteolol.Approved
CastanospermineThe risk or severity of adverse effects can be increased when Castanospermine is combined with Semapimod.Experimental
CelecoxibThe risk or severity of adverse effects can be increased when Semapimod is combined with Celecoxib.Approved, Investigational
CeliprololSemapimod may decrease the antihypertensive activities of Celiprolol.Approved, Investigational
CertoparinSemapimod may increase the anticoagulant activities of Certoparin.Approved, Investigational
ChloroquineThe risk or severity of adverse effects can be increased when Chloroquine is combined with Semapimod.Approved, Investigational, Vet Approved
ChlorothiazideThe therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Semapimod.Approved, Vet Approved
ChlorphenesinThe risk or severity of adverse effects can be increased when Semapimod is combined with Chlorphenesin.Approved, Vet Approved, Withdrawn
ChlorthalidoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Semapimod.Approved
CholestyramineCholestyramine can cause a decrease in the absorption of Semapimod resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Choline magnesium trisalicylateThe risk or severity of adverse effects can be increased when Semapimod is combined with Choline magnesium trisalicylate.Approved
CiclesonideThe risk or severity of adverse effects can be increased when Semapimod is combined with Ciclesonide.Approved, Investigational
CilazaprilThe risk or severity of adverse effects can be increased when Semapimod is combined with Cilazapril.Approved
CimicoxibThe risk or severity of adverse effects can be increased when Semapimod is combined with Cimicoxib.Investigational
CinoxacinSemapimod may increase the neuroexcitatory activities of Cinoxacin.Approved, Investigational, Withdrawn
CisplatinThe risk or severity of adverse effects can be increased when Semapimod is combined with Cisplatin.Approved
ClobetasolThe risk or severity of adverse effects can be increased when Semapimod is combined with Clobetasol.Approved, Investigational
Clobetasol propionateThe risk or severity of adverse effects can be increased when Semapimod is combined with Clobetasol propionate.Approved
ClobetasoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Clobetasone.Approved
ClocortoloneThe risk or severity of adverse effects can be increased when Semapimod is combined with Clocortolone.Approved
Clodronic AcidThe risk or severity of adverse effects can be increased when Semapimod is combined with Clodronic Acid.Approved, Investigational, Vet Approved
ClonixinThe risk or severity of adverse effects can be increased when Clonixin is combined with Semapimod.Approved
CloprostenolThe therapeutic efficacy of Cloprostenol can be decreased when used in combination with Semapimod.Vet Approved
CloranololSemapimod may decrease the antihypertensive activities of Cloranolol.Experimental
Clostridium tetani toxoid antigen (formaldehyde inactivated)The risk or severity of adverse effects can be increased when Semapimod is combined with Clostridium tetani toxoid antigen (formaldehyde inactivated).Approved
ColesevelamColesevelam can cause a decrease in the absorption of Semapimod resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Semapimod resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Cortexolone 17α-propionateThe risk or severity of adverse effects can be increased when Semapimod is combined with Cortexolone 17α-propionate.Investigational
CorticosteroneThe risk or severity of adverse effects can be increased when Semapimod is combined with Corticosterone.Experimental
Cortisone acetateThe risk or severity of adverse effects can be increased when Semapimod is combined with Cortisone acetate.Approved, Investigational
Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)The risk or severity of adverse effects can be increased when Semapimod is combined with Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated).Approved
CurcuminThe risk or severity of adverse effects can be increased when Curcumin is combined with Semapimod.Approved, Investigational
CyclopenthiazideThe therapeutic efficacy of Cyclopenthiazide can be decreased when used in combination with Semapimod.Experimental
Dabigatran etexilateSemapimod may increase the anticoagulant activities of Dabigatran etexilate.Approved
DalteparinSemapimod may increase the anticoagulant activities of Dalteparin.Approved
DanaparoidSemapimod may increase the anticoagulant activities of Danaparoid.Approved, Withdrawn
DarexabanSemapimod may increase the anticoagulant activities of Darexaban.Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Semapimod is combined with Deferasirox.Approved, Investigational
DeflazacortThe risk or severity of adverse effects can be increased when Semapimod is combined with Deflazacort.Approved, Investigational
DelaprilThe risk or severity of adverse effects can be increased when Semapimod is combined with Delapril.Investigational
DenosumabThe risk or severity of adverse effects can be increased when Denosumab is combined with Semapimod.Approved
DesipramineSemapimod may decrease the antihypertensive activities of Desipramine.Approved, Investigational
DesirudinSemapimod may increase the anticoagulant activities of Desirudin.Approved
DesonideThe risk or severity of adverse effects can be increased when Semapimod is combined with Desonide.Approved, Investigational
DesoximetasoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Desoximetasone.Approved
Desoxycorticosterone acetateThe risk or severity of adverse effects can be increased when Semapimod is combined with Desoxycorticosterone acetate.Approved
Desoxycorticosterone PivalateThe risk or severity of adverse effects can be increased when Semapimod is combined with Desoxycorticosterone Pivalate.Experimental, Vet Approved
Dexamethasone isonicotinateThe risk or severity of adverse effects can be increased when Semapimod is combined with Dexamethasone isonicotinate.Vet Approved
DexibuprofenThe risk or severity of adverse effects can be increased when Semapimod is combined with Dexibuprofen.Approved, Investigational
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Semapimod.Approved, Investigational
DextranSemapimod may increase the anticoagulant activities of Dextran.Approved, Investigational, Vet Approved
DibekacinSemapimod may decrease the excretion rate of Dibekacin which could result in a higher serum level.Experimental
Dibotermin alfaThe risk or severity of adverse effects can be increased when Semapimod is combined with Dibotermin alfa.Approved, Investigational
DicoumarolSemapimod may increase the anticoagulant activities of Dicoumarol.Approved
DifenpiramideThe risk or severity of adverse effects can be increased when Semapimod is combined with Difenpiramide.Experimental
DiflorasoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Diflorasone.Approved
DiflunisalThe risk or severity of adverse effects can be increased when Semapimod is combined with Diflunisal.Approved, Investigational
DifluocortoloneThe risk or severity of adverse effects can be increased when Semapimod is combined with Difluocortolone.Approved, Investigational, Withdrawn
DifluprednateThe risk or severity of adverse effects can be increased when Semapimod is combined with Difluprednate.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Semapimod.Approved
DihydrostreptomycinSemapimod may decrease the excretion rate of Dihydrostreptomycin which could result in a higher serum level.Investigational, Vet Approved
DinoprostThe therapeutic efficacy of Dinoprost can be decreased when used in combination with Semapimod.Investigational
Dinoprost TromethamineThe therapeutic efficacy of Dinoprost Tromethamine can be decreased when used in combination with Semapimod.Approved, Vet Approved
DinoprostoneThe therapeutic efficacy of Dinoprostone can be decreased when used in combination with Semapimod.Approved
DrospirenoneSemapimod may increase the hyperkalemic activities of Drospirenone.Approved
DroxicamThe risk or severity of adverse effects can be increased when Semapimod is combined with Droxicam.Withdrawn
DuvelisibThe risk or severity of adverse effects can be increased when Duvelisib is combined with Semapimod.Investigational
E-6201The risk or severity of adverse effects can be increased when E-6201 is combined with Semapimod.Investigational
Edetic AcidSemapimod may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanSemapimod may increase the anticoagulant activities of Edoxaban.Approved
EnalaprilThe risk or severity of adverse effects can be increased when Semapimod is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe risk or severity of adverse effects can be increased when Semapimod is combined with Enalaprilat.Approved
EnoxacinSemapimod may increase the neuroexcitatory activities of Enoxacin.Approved, Investigational
EnoxaparinSemapimod may increase the anticoagulant activities of Enoxaparin.Approved
EnprostilThe therapeutic efficacy of Enprostil can be decreased when used in combination with Semapimod.Experimental
EpanololSemapimod may decrease the antihypertensive activities of Epanolol.Experimental
EpirizoleThe risk or severity of adverse effects can be increased when Epirizole is combined with Semapimod.Approved
EpitizideThe therapeutic efficacy of Epitizide can be decreased when used in combination with Semapimod.Experimental
EplerenoneSemapimod may decrease the antihypertensive activities of Eplerenone.Approved
EpoprostenolThe therapeutic efficacy of Epoprostenol can be decreased when used in combination with Semapimod.Approved
EprosartanThe risk or severity of adverse effects can be increased when Eprosartan is combined with Semapimod.Approved
EquileninThe risk or severity of adverse effects can be increased when Semapimod is combined with Equilenin.Experimental
EquilinThe risk or severity of adverse effects can be increased when Semapimod is combined with Equilin.Approved
EsatenololSemapimod may decrease the antihypertensive activities of Esatenolol.Experimental
EsmololSemapimod may decrease the antihypertensive activities of Esmolol.Approved
EstroneThe risk or severity of adverse effects can be increased when Semapimod is combined with Estrone.Approved
Estrone sulfateThe risk or severity of adverse effects can be increased when Semapimod is combined with Estrone sulfate.Approved
Etacrynic acidThe therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Semapimod.Approved, Investigational
EthenzamideThe risk or severity of adverse effects can be increased when Semapimod is combined with Ethenzamide.Experimental
Ethyl biscoumacetateSemapimod may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
Etidronic acidThe risk or severity of adverse effects can be increased when Semapimod is combined with Etidronic acid.Approved
EtodolacThe risk or severity of adverse effects can be increased when Semapimod is combined with Etodolac.Approved, Investigational, Vet Approved
EtofenamateThe risk or severity of adverse effects can be increased when Etofenamate is combined with Semapimod.Approved, Investigational
EtoricoxibThe risk or severity of adverse effects can be increased when Semapimod is combined with Etoricoxib.Approved, Investigational
Evening primrose oilThe risk or severity of adverse effects can be increased when Evening primrose oil is combined with Semapimod.Investigational, Nutraceutical
ExisulindThe risk or severity of adverse effects can be increased when Exisulind is combined with Semapimod.Investigational
FelbinacThe risk or severity of adverse effects can be increased when Felbinac is combined with Semapimod.Experimental
FenbufenThe risk or severity of adverse effects can be increased when Fenbufen is combined with Semapimod.Approved
FenoprofenThe risk or severity of adverse effects can be increased when Semapimod is combined with Fenoprofen.Approved
FenprostaleneThe therapeutic efficacy of Fenprostalene can be decreased when used in combination with Semapimod.Vet Approved
FentiazacThe risk or severity of adverse effects can be increased when Semapimod is combined with Fentiazac.Experimental
FeprazoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Feprazone.Experimental
Ferulic acidSemapimod may increase the anticoagulant activities of Ferulic acid.Experimental
FimasartanThe risk or severity of adverse effects can be increased when Fimasartan is combined with Semapimod.Approved, Investigational
FingolimodSemapimod may increase the immunosuppressive activities of Fingolimod.Approved, Investigational
FleroxacinSemapimod may increase the neuroexcitatory activities of Fleroxacin.Approved
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Semapimod.Approved, Withdrawn
FluasteroneThe risk or severity of adverse effects can be increased when Semapimod is combined with Fluasterone.Investigational
FludrocortisoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Fludrocortisone.Approved, Investigational
FluindioneSemapimod may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlumequineSemapimod may increase the neuroexcitatory activities of Flumequine.Withdrawn
FlumethasoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Flumethasone.Approved, Vet Approved
FlunisolideThe risk or severity of adverse effects can be increased when Semapimod is combined with Flunisolide.Approved, Investigational
FlunixinThe risk or severity of adverse effects can be increased when Flunixin is combined with Semapimod.Vet Approved
FlunoxaprofenThe risk or severity of adverse effects can be increased when Semapimod is combined with Flunoxaprofen.Experimental
Fluocinolone AcetonideThe risk or severity of adverse effects can be increased when Semapimod is combined with Fluocinolone Acetonide.Approved, Investigational, Vet Approved
FluocinonideThe risk or severity of adverse effects can be increased when Semapimod is combined with Fluocinonide.Approved, Investigational
FluocortoloneThe risk or severity of adverse effects can be increased when Semapimod is combined with Fluocortolone.Approved, Withdrawn
FluorometholoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Fluorometholone.Approved, Investigational
FluprednideneThe risk or severity of adverse effects can be increased when Semapimod is combined with Fluprednidene.Approved, Withdrawn
FluprednisoloneThe risk or severity of adverse effects can be increased when Semapimod is combined with Fluprednisolone.Approved
FluprostenolThe therapeutic efficacy of Fluprostenol can be decreased when used in combination with Semapimod.Vet Approved
FlurandrenolideThe risk or severity of adverse effects can be increased when Semapimod is combined with Flurandrenolide.Approved
FlurbiprofenThe risk or severity of adverse effects can be increased when Semapimod is combined with Flurbiprofen.Approved, Investigational
FluticasoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Fluticasone.Approved, Experimental, Investigational
Fluticasone furoateThe risk or severity of adverse effects can be increased when Semapimod is combined with Fluticasone furoate.Approved
Folic AcidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Semapimod.Approved, Nutraceutical, Vet Approved
FondaparinuxSemapimod may increase the anticoagulant activities of Fondaparinux sodium.Approved, Investigational
ForasartanThe risk or severity of adverse effects can be increased when Forasartan is combined with Semapimod.Experimental
FormestaneThe risk or severity of adverse effects can be increased when Semapimod is combined with Formestane.Approved, Investigational, Withdrawn
FramycetinSemapimod may decrease the excretion rate of Framycetin which could result in a higher serum level.Approved
G17DTThe risk or severity of adverse effects can be increased when Semapimod is combined with G17DT.Investigational
GabexateSemapimod may increase the anticoagulant activities of Gabexate.Investigational
GarenoxacinSemapimod may increase the neuroexcitatory activities of Garenoxacin.Investigational
GatifloxacinSemapimod may increase the neuroexcitatory activities of Gatifloxacin.Approved, Investigational
GemeprostThe therapeutic efficacy of Gemeprost can be decreased when used in combination with Semapimod.Approved, Withdrawn
GemifloxacinSemapimod may increase the neuroexcitatory activities of Gemifloxacin.Approved, Investigational
GeneticinSemapimod may decrease the excretion rate of Geneticin which could result in a higher serum level.Experimental
GentamicinSemapimod may decrease the excretion rate of Gentamicin which could result in a higher serum level.Approved, Vet Approved
GENTAMICIN C1ASemapimod may decrease the excretion rate of GENTAMICIN C1A which could result in a higher serum level.Experimental
GI-5005The risk or severity of adverse effects can be increased when Semapimod is combined with GI-5005.Investigational
GinsengThe risk or severity of adverse effects can be increased when Semapimod is combined with Ginseng.Approved, Investigational, Nutraceutical
GrepafloxacinSemapimod may increase the neuroexcitatory activities of Grepafloxacin.Approved, Investigational, Withdrawn
GuacetisalThe risk or severity of adverse effects can be increased when Semapimod is combined with Guacetisal.Experimental
HalcinonideThe risk or severity of adverse effects can be increased when Semapimod is combined with Halcinonide.Approved, Investigational, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Semapimod is combined with Haloperidol.Approved
HE3286The risk or severity of adverse effects can be increased when Semapimod is combined with HE3286.Investigational
HeparinSemapimod may increase the anticoagulant activities of Heparin.Approved, Investigational
Hepatitis A VaccineThe risk or severity of adverse effects can be increased when Semapimod is combined with Hepatitis A Vaccine.Approved
Hepatitis B Vaccine (Recombinant)The risk or severity of adverse effects can be increased when Semapimod is combined with Hepatitis B Vaccine (Recombinant).Approved, Withdrawn
HigenamineThe risk or severity of adverse effects can be increased when Semapimod is combined with Higenamine.Investigational
Human rabies virus immune globulinThe risk or severity of adverse effects can be increased when Semapimod is combined with Human rabies virus immune globulin.Approved
HydralazineSemapimod may decrease the antihypertensive activities of Hydralazine.Approved
HydroflumethiazideThe therapeutic efficacy of Hydroflumethiazide can be decreased when used in combination with Semapimod.Approved, Investigational
Hygromycin BSemapimod may decrease the excretion rate of Hygromycin B which could result in a higher serum level.Vet Approved
IbuproxamThe risk or severity of adverse effects can be increased when Ibuproxam is combined with Semapimod.Withdrawn
IcatibantThe risk or severity of adverse effects can be increased when Icatibant is combined with Semapimod.Approved, Investigational
IcosapentThe risk or severity of adverse effects can be increased when Semapimod is combined with Icosapent.Approved, Nutraceutical
IdraparinuxSemapimod may increase the anticoagulant activities of Idraparinux.Investigational
IloprostThe therapeutic efficacy of Iloprost can be decreased when used in combination with Semapimod.Approved, Investigational
ImidaprilThe risk or severity of adverse effects can be increased when Semapimod is combined with Imidapril.Investigational
Imidazole salicylateThe risk or severity of adverse effects can be increased when Semapimod is combined with Imidazole salicylate.Experimental
IndapamideThe therapeutic efficacy of Indapamide can be decreased when used in combination with Semapimod.Approved
IndenololSemapimod may decrease the antihypertensive activities of Indenolol.Withdrawn
IndobufenThe risk or severity of adverse effects can be increased when Semapimod is combined with Indobufen.Investigational
IndomethacinThe risk or severity of adverse effects can be increased when Semapimod is combined with Indomethacin.Approved, Investigational
IndoprofenThe risk or severity of adverse effects can be increased when Indoprofen is combined with Semapimod.Withdrawn
INGN 201The risk or severity of adverse effects can be increased when Semapimod is combined with INGN 201.Investigational
INGN 225The risk or severity of adverse effects can be increased when Semapimod is combined with INGN 225.Investigational
IrbesartanThe risk or severity of adverse effects can be increased when Irbesartan is combined with Semapimod.Approved, Investigational
IsepamicinSemapimod may decrease the excretion rate of Isepamicin which could result in a higher serum level.Experimental
IsoxicamThe risk or severity of adverse effects can be increased when Isoxicam is combined with Semapimod.Withdrawn
IstaroximeThe risk or severity of adverse effects can be increased when Semapimod is combined with Istaroxime.Investigational
Japanese encephalitis virus strain sa 14-14-2 antigen (formaldehyde inactivated)The risk or severity of adverse effects can be increased when Semapimod is combined with Japanese encephalitis virus strain sa 14-14-2 antigen (formaldehyde inactivated).Approved
KanamycinSemapimod may decrease the excretion rate of Kanamycin which could result in a higher serum level.Approved, Investigational, Vet Approved
KebuzoneThe risk or severity of adverse effects can be increased when Kebuzone is combined with Semapimod.Experimental
KetoprofenThe risk or severity of adverse effects can be increased when Semapimod is combined with Ketoprofen.Approved, Vet Approved
LandiololSemapimod may decrease the antihypertensive activities of Landiolol.Investigational
Latanoprostene BunodThe therapeutic efficacy of Latanoprostene Bunod can be decreased when used in combination with Semapimod.Approved, Investigational
LeflunomideThe risk or severity of adverse effects can be increased when Semapimod is combined with Leflunomide.Approved, Investigational
LepirudinSemapimod may increase the anticoagulant activities of Lepirudin.Approved
LetaxabanSemapimod may increase the anticoagulant activities of Letaxaban.Investigational
LevobetaxololSemapimod may decrease the antihypertensive activities of Levobetaxolol.Approved, Investigational
LevobunololSemapimod may decrease the antihypertensive activities of Levobunolol.Approved
LevofloxacinSemapimod may increase the neuroexcitatory activities of Levofloxacin.Approved, Investigational
LimaprostThe therapeutic efficacy of Limaprost can be decreased when used in combination with Semapimod.Approved, Investigational
LisinoprilThe risk or severity of adverse effects can be increased when Semapimod is combined with Lisinopril.Approved, Investigational
LisofyllineThe risk or severity of adverse effects can be increased when Semapimod is combined with Lisofylline.Investigational
Lithium cationThe serum concentration of Lithium can be increased when it is combined with Semapimod.Experimental
LomefloxacinSemapimod may increase the neuroexcitatory activities of Lomefloxacin.Approved, Investigational
LonazolacThe risk or severity of adverse effects can be increased when Semapimod is combined with Lonazolac.Experimental
LornoxicamThe risk or severity of adverse effects can be increased when Semapimod is combined with Lornoxicam.Approved, Investigational
LoteprednolThe risk or severity of adverse effects can be increased when Semapimod is combined with Loteprednol.Approved
LoxoprofenThe risk or severity of adverse effects can be increased when Loxoprofen is combined with Semapimod.Approved, Investigational
LubiprostoneThe therapeutic efficacy of Lubiprostone can be decreased when used in combination with Semapimod.Approved, Investigational
LumiracoxibThe risk or severity of adverse effects can be increased when Semapimod is combined with Lumiracoxib.Approved, Investigational
LuprostiolThe therapeutic efficacy of Luprostiol can be decreased when used in combination with Semapimod.Vet Approved
Magnesium salicylateThe risk or severity of adverse effects can be increased when Semapimod is combined with Magnesium salicylate.Approved
MasoprocolThe risk or severity of adverse effects can be increased when Masoprocol is combined with Semapimod.Approved, Investigational
ME-609The risk or severity of adverse effects can be increased when Semapimod is combined with ME-609.Investigational
Meclofenamic acidThe risk or severity of adverse effects can be increased when Semapimod is combined with Meclofenamic acid.Approved, Vet Approved
MedrysoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Medrysone.Approved
Mefenamic acidThe risk or severity of adverse effects can be increased when Semapimod is combined with Mefenamic acid.Approved
MelagatranSemapimod may increase the anticoagulant activities of Melagatran.Experimental
MelengestrolThe risk or severity of adverse effects can be increased when Semapimod is combined with Melengestrol.Vet Approved
MeloxicamThe risk or severity of adverse effects can be increased when Semapimod is combined with Meloxicam.Approved, Vet Approved
MepindololSemapimod may decrease the antihypertensive activities of Mepindolol.Experimental
MesalazineThe risk or severity of adverse effects can be increased when Semapimod is combined with Mesalazine.Approved
MetamizoleThe risk or severity of adverse effects can be increased when Metamizole is combined with Semapimod.Approved, Investigational, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Semapimod.Approved
MethyclothiazideThe therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Semapimod.Approved
MetipranololSemapimod may decrease the antihypertensive activities of Metipranolol.Approved
MetolazoneThe therapeutic efficacy of Metolazone can be decreased when used in combination with Semapimod.Approved
MicronomicinSemapimod may decrease the excretion rate of Micronomicin which could result in a higher serum level.Experimental
MifamurtideThe therapeutic efficacy of Mifamurtide can be decreased when used in combination with Semapimod.Approved, Experimental
MisoprostolThe therapeutic efficacy of Misoprostol can be decreased when used in combination with Semapimod.Approved
MizoribineThe risk or severity of adverse effects can be increased when Semapimod is combined with Mizoribine.Investigational
MoexiprilThe risk or severity of adverse effects can be increased when Semapimod is combined with Moexipril.Approved
MofebutazoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Mofebutazone.Experimental
MometasoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Mometasone.Approved, Vet Approved
MorniflumateThe risk or severity of adverse effects can be increased when Morniflumate is combined with Semapimod.Approved
Mycophenolate mofetilThe risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Semapimod.Approved, Investigational
Mycophenolic acidThe risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Semapimod.Approved
NabumetoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Nabumetone.Approved
NadololSemapimod may decrease the antihypertensive activities of Nadolol.Approved
NadroparinSemapimod may increase the anticoagulant activities of Nadroparin.Approved, Investigational
NafamostatSemapimod may increase the anticoagulant activities of Nafamostat.Approved, Investigational
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Semapimod.Approved
Nalidixic AcidSemapimod may increase the neuroexcitatory activities of Nalidixic Acid.Approved, Investigational
NatalizumabThe risk or severity of adverse effects can be increased when Semapimod is combined with Natalizumab.Approved, Investigational
NCX 1022The risk or severity of adverse effects can be increased when Semapimod is combined with NCX 1022.Investigational
NeamineSemapimod may decrease the excretion rate of Neamine which could result in a higher serum level.Experimental
NebivololSemapimod may decrease the antihypertensive activities of Nebivolol.Approved, Investigational
NemonoxacinSemapimod may increase the neuroexcitatory activities of Nemonoxacin.Investigational
NepafenacThe risk or severity of adverse effects can be increased when Semapimod is combined with Nepafenac.Approved, Investigational
NetilmicinSemapimod may decrease the excretion rate of Netilmicin which could result in a higher serum level.Approved, Investigational
NifenazoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Nifenazone.Experimental
Niflumic AcidThe risk or severity of adverse effects can be increased when Semapimod is combined with Niflumic Acid.Approved
NitroaspirinThe risk or severity of adverse effects can be increased when Semapimod is combined with Nitroaspirin.Investigational
NorfloxacinSemapimod may increase the neuroexcitatory activities of Norfloxacin.Approved
OcrelizumabOcrelizumab may increase the immunosuppressive activities of Semapimod.Approved, Investigational
OfloxacinSemapimod may increase the neuroexcitatory activities of Ofloxacin.Approved
Oleoyl-estroneThe risk or severity of adverse effects can be increased when Semapimod is combined with Oleoyl-estrone.Investigational
OlmesartanThe risk or severity of adverse effects can be increased when Olmesartan is combined with Semapimod.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Semapimod.Approved
OlsalazineSemapimod may increase the nephrotoxic activities of Olsalazine.Approved
Omacetaxine mepesuccinateThe risk or severity of bleeding can be increased when Semapimod is combined with Omacetaxine mepesuccinate.Approved, Investigational
OmapatrilatThe risk or severity of adverse effects can be increased when Semapimod is combined with Omapatrilat.Investigational
OrgoteinThe risk or severity of adverse effects can be increased when Orgotein is combined with Semapimod.Vet Approved
OtamixabanSemapimod may increase the anticoagulant activities of Otamixaban.Investigational
OxaprozinThe risk or severity of adverse effects can be increased when Semapimod is combined with Oxaprozin.Approved
Oxolinic acidSemapimod may increase the neuroexcitatory activities of Oxolinic acid.Experimental
OxprenololSemapimod may decrease the antihypertensive activities of Oxprenolol.Approved
OxyphenbutazoneThe risk or severity of adverse effects can be increased when Oxyphenbutazone is combined with Semapimod.Approved, Withdrawn
PalmidrolThe risk or severity of adverse effects can be increased when Semapimod is combined with Palmidrol.Experimental, Nutraceutical
PamidronateThe risk or severity of adverse effects can be increased when Semapimod is combined with Pamidronate.Approved
ParamethasoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Paramethasone.Approved
ParecoxibThe risk or severity of adverse effects can be increased when Semapimod is combined with Parecoxib.Approved
ParthenolideThe risk or severity of adverse effects can be increased when Semapimod is combined with Parthenolide.Approved, Investigational
PazufloxacinSemapimod may increase the neuroexcitatory activities of Pazufloxacin.Investigational
PefloxacinSemapimod may increase the neuroexcitatory activities of Pefloxacin.Approved
PenbutololSemapimod may decrease the antihypertensive activities of Penbutolol.Approved, Investigational
Pentaerythritol TetranitrateSemapimod may increase the anticoagulant activities of Pentaerythritol Tetranitrate.Approved
Pentosan PolysulfateSemapimod may increase the anticoagulant activities of Pentosan Polysulfate.Approved
PerindoprilThe risk or severity of adverse effects can be increased when Semapimod is combined with Perindopril.Approved
PhenindioneSemapimod may increase the anticoagulant activities of Phenindione.Approved, Investigational
PhenprocoumonSemapimod may increase the anticoagulant activities of Phenprocoumon.Approved, Investigational
PhenylbutazoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Phenylbutazone.Approved, Vet Approved
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Semapimod.Approved, Investigational
PindololSemapimod may decrease the antihypertensive activities of Pindolol.Approved, Investigational
Pipemidic acidSemapimod may increase the neuroexcitatory activities of Pipemidic acid.Experimental
PiretanideThe therapeutic efficacy of Piretanide can be decreased when used in combination with Semapimod.Approved
PirfenidoneThe risk or severity of adverse effects can be increased when Pirfenidone is combined with Semapimod.Approved, Investigational
Piromidic acidSemapimod may increase the neuroexcitatory activities of Piromidic acid.Experimental
PiroxicamThe risk or severity of adverse effects can be increased when Semapimod is combined with Piroxicam.Approved, Investigational
PirprofenThe risk or severity of adverse effects can be increased when Semapimod is combined with Pirprofen.Experimental
PitolisantThe risk or severity of adverse effects can be increased when Semapimod is combined with Pitolisant.Approved, Investigational
Platelet Activating FactorSemapimod may decrease the antihypertensive activities of Platelet Activating Factor.Experimental
PlazomicinSemapimod may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
PolythiazideThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Semapimod.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Semapimod is combined with Pomalidomide.Approved
Potassium CitrateSemapimod may increase the anticoagulant activities of Potassium Citrate.Approved, Investigational, Vet Approved
PractololSemapimod may decrease the antihypertensive activities of Practolol.Approved
PralatrexateThe serum concentration of Pralatrexate can be increased when it is combined with Semapimod.Approved, Investigational
PranoprofenThe risk or severity of adverse effects can be increased when Semapimod is combined with Pranoprofen.Experimental, Investigational
PrasteroneThe risk or severity of adverse effects can be increased when Semapimod is combined with Prasterone.Approved, Investigational, Nutraceutical
Prasterone sulfateThe risk or severity of adverse effects can be increased when Semapimod is combined with Prasterone sulfate.Investigational
PrednicarbateThe risk or severity of adverse effects can be increased when Semapimod is combined with Prednicarbate.Approved, Investigational
PrednisoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Prednisone.Approved, Vet Approved
PregnenoloneThe risk or severity of adverse effects can be increased when Semapimod is combined with Pregnenolone.Approved, Experimental, Investigational
ProbenecidThe serum concentration of Semapimod can be increased when it is combined with Probenecid.Approved, Investigational
ProglumetacinThe risk or severity of adverse effects can be increased when Semapimod is combined with Proglumetacin.Experimental
PropacetamolThe risk or severity of adverse effects can be increased when Propacetamol is combined with Semapimod.Approved, Investigational
PropyphenazoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Propyphenazone.Experimental
ProquazoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Proquazone.Experimental
Prostaglandin B2The therapeutic efficacy of Prostaglandin B2 can be decreased when used in combination with Semapimod.Experimental
Prostaglandin G2The therapeutic efficacy of Prostaglandin G2 can be decreased when used in combination with Semapimod.Experimental
ProstaleneThe therapeutic efficacy of Prostalene can be decreased when used in combination with Semapimod.Vet Approved
Protein CSemapimod may increase the anticoagulant activities of Protein C.Approved
Protein S humanSemapimod may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeSemapimod may increase the anticoagulant activities of Protocatechualdehyde.Approved
PrulifloxacinSemapimod may increase the neuroexcitatory activities of Prulifloxacin.Investigational
PTC299The risk or severity of adverse effects can be increased when PTC299 is combined with Semapimod.Investigational
PuromycinSemapimod may decrease the excretion rate of Puromycin which could result in a higher serum level.Experimental
QuinaprilThe risk or severity of adverse effects can be increased when Semapimod is combined with Quinapril.Approved, Investigational
QuinethazoneThe therapeutic efficacy of Quinethazone can be decreased when used in combination with Semapimod.Approved
Rabies virus inactivated antigen, AThe risk or severity of adverse effects can be increased when Semapimod is combined with Rabies virus inactivated antigen, A.Approved, Investigational
Rabies virus inactivated antigen, AThe therapeutic efficacy of Rabies virus inactivated antigen, A can be decreased when used in combination with Semapimod.Approved, Investigational
RamiprilThe risk or severity of adverse effects can be increased when Semapimod is combined with Ramipril.Approved
RescinnamineThe risk or severity of adverse effects can be increased when Semapimod is combined with Rescinnamine.Approved
ResveratrolThe risk or severity of adverse effects can be increased when Semapimod is combined with Resveratrol.Approved, Experimental, Investigational
ReviparinSemapimod may increase the anticoagulant activities of Reviparin.Approved, Investigational
RibostamycinSemapimod may decrease the excretion rate of Ribostamycin which could result in a higher serum level.Approved, Investigational
RimexoloneThe risk or severity of adverse effects can be increased when Semapimod is combined with Rimexolone.Approved
RindopepimutThe risk or severity of adverse effects can be increased when Semapimod is combined with Rindopepimut.Investigational
RisedronateThe risk or severity of adverse effects can be increased when Semapimod is combined with Risedronate.Approved, Investigational
RivaroxabanSemapimod may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibThe risk or severity of adverse effects can be increased when Semapimod is combined with Rofecoxib.Approved, Investigational, Withdrawn
RoflumilastRoflumilast may increase the immunosuppressive activities of Semapimod.Approved
RosoxacinSemapimod may increase the neuroexcitatory activities of Rosoxacin.Approved, Investigational
Rotavirus VaccineThe risk or severity of adverse effects can be increased when Semapimod is combined with Rotavirus Vaccine.Approved
Rubella virus vaccineThe risk or severity of adverse effects can be increased when Semapimod is combined with Rubella virus vaccine.Approved, Investigational
RufloxacinSemapimod may increase the neuroexcitatory activities of Rufloxacin.Experimental
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Semapimod.Approved
SalicylamideThe risk or severity of adverse effects can be increased when Salicylamide is combined with Semapimod.Approved
Salmonella typhi ty2 vi polysaccharide antigenThe risk or severity of adverse effects can be increased when Semapimod is combined with Salmonella typhi ty2 vi polysaccharide antigen.Approved
Salmonella typhi Ty21a live antigenThe risk or severity of adverse effects can be increased when Semapimod is combined with Salmonella typhi ty21a live antigen.Approved
SalsalateThe risk or severity of adverse effects can be increased when Semapimod is combined with Salsalate.Approved
SaprisartanThe risk or severity of adverse effects can be increased when Saprisartan is combined with Semapimod.Experimental
SaralasinThe risk or severity of adverse effects can be increased when Saralasin is combined with Semapimod.Investigational
SarilumabSarilumab may increase the immunosuppressive activities of Semapimod.Approved, Investigational
SeliciclibThe risk or severity of adverse effects can be increased when Semapimod is combined with Seliciclib.Investigational
SeratrodastThe risk or severity of adverse effects can be increased when Seratrodast is combined with Semapimod.Approved
SerrapeptaseThe risk or severity of adverse effects can be increased when Semapimod is combined with Serrapeptase.Investigational
SisomicinSemapimod may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
SitafloxacinSemapimod may increase the neuroexcitatory activities of Sitafloxacin.Experimental, Investigational
SotalolSemapimod may decrease the antihypertensive activities of Sotalol.Approved
SparfloxacinSemapimod may increase the neuroexcitatory activities of Sparfloxacin.Approved, Investigational
SpiraprilThe risk or severity of adverse effects can be increased when Semapimod is combined with Spirapril.Approved
SRP 299The risk or severity of adverse effects can be increased when Semapimod is combined with SRP 299.Investigational
SRT501The risk or severity of adverse effects can be increased when SRT501 is combined with Semapimod.Investigational
StreptomycinSemapimod may decrease the excretion rate of Streptomycin which could result in a higher serum level.Approved, Vet Approved
SulodexideSemapimod may increase the anticoagulant activities of Sulodexide.Approved, Investigational
SulprostoneThe therapeutic efficacy of Sulprostone can be decreased when used in combination with Semapimod.Investigational
SuprofenThe risk or severity of adverse effects can be increased when Semapimod is combined with Suprofen.Approved, Withdrawn
SuxibuzoneThe risk or severity of adverse effects can be increased when Semapimod is combined with Suxibuzone.Experimental
TacrolimusTacrolimus may increase the immunosuppressive activities of Semapimod.Approved, Investigational
TafluprostThe therapeutic efficacy of Tafluprost can be decreased when used in combination with Semapimod.Approved
TalinololSemapimod may decrease the antihypertensive activities of Talinolol.Investigational
TalniflumateThe risk or severity of adverse effects can be increased when Talniflumate is combined with Semapimod.Approved
TarenflurbilThe risk or severity of adverse effects can be increased when Tarenflurbil is combined with Semapimod.Investigational
TasosartanThe risk or severity of adverse effects can be increased when Tasosartan is combined with Semapimod.Approved
TecemotideThe risk or severity of adverse effects can be increased when Semapimod is combined with Tecemotide.Investigational
Technetium Tc-99m etidronateThe risk or severity of adverse effects can be increased when Semapimod is combined with Technetium Tc-99m etidronate.Approved
Technetium Tc-99m medronateThe risk or severity of adverse effects can be increased when Semapimod is combined with Technetium Tc-99m medronate.Approved
TelmisartanThe risk or severity of adverse effects can be increased when Telmisartan is combined with Semapimod.Approved, Investigational
TemafloxacinSemapimod may increase the neuroexcitatory activities of Temafloxacin.Withdrawn
TemocaprilThe risk or severity of adverse effects can be increased when Semapimod is combined with Temocapril.Experimental, Investigational
TenidapThe risk or severity of adverse effects can be increased when Semapimod is combined with Tenidap.Experimental
Tenofovir disoproxilThe risk or severity of adverse effects can be increased when Semapimod is combined with Tenofovir disoproxil.Approved, Investigational
TenoxicamThe risk or severity of adverse effects can be increased when Semapimod is combined with Tenoxicam.Approved
TepoxalinThe risk or severity of adverse effects can be increased when Tepoxalin is combined with Semapimod.Vet Approved
TerbutalineSemapimod may decrease the antihypertensive activities of Terbutaline.Approved
TeriflunomideThe risk or severity of adverse effects can be increased when Teriflunomide is combined with Semapimod.Approved
TertatololSemapimod may decrease the antihypertensive activities of Tertatolol.Experimental
TG4010The risk or severity of adverse effects can be increased when Semapimod is combined with TG4010.Investigational
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Semapimod is combined with Tiaprofenic acid.Approved
Tiludronic acidThe risk or severity of adverse effects can be increased when Semapimod is combined with Tiludronic acid.Approved, Investigational, Vet Approved
TimololSemapimod may decrease the antihypertensive activities of Timolol.Approved
TinoridineThe risk or severity of adverse effects can be increased when Semapimod is combined with Tinoridine.Investigational
TixocortolThe risk or severity of adverse effects can be increased when Semapimod is combined with Tixocortol.Approved, Withdrawn
TobramycinSemapimod may decrease the excretion rate of Tobramycin which could result in a higher serum level.Approved, Investigational
TofacitinibSemapimod may increase the immunosuppressive activities of Tofacitinib.Approved, Investigational
TolmetinThe risk or severity of adverse effects can be increased when Semapimod is combined with Tolmetin.Approved
TorasemideThe therapeutic efficacy of Torasemide can be decreased when used in combination with Semapimod.Approved
TrandolaprilThe risk or severity of adverse effects can be increased when Semapimod is combined with Trandolapril.Approved
TrastuzumabTrastuzumab may increase the neutropenic activities of Semapimod.Approved, Investigational
TravoprostThe therapeutic efficacy of Travoprost can be decreased when used in combination with Semapimod.Approved
TreprostinilThe risk or severity of adverse effects can be increased when Treprostinil is combined with Semapimod.Approved, Investigational
TriamcinoloneThe risk or severity of adverse effects can be increased when Semapimod is combined with Triamcinolone.Approved, Vet Approved
TriamtereneSemapimod may decrease the antihypertensive activities of Triamterene.Approved
TribenosideThe risk or severity of adverse effects can be increased when Semapimod is combined with Tribenoside.Experimental
TrichlormethiazideThe therapeutic efficacy of Trichlormethiazide can be decreased when used in combination with Semapimod.Approved, Vet Approved
TriptolideThe risk or severity of adverse effects can be increased when Triptolide is combined with Semapimod.Investigational
TrovafloxacinSemapimod may increase the neuroexcitatory activities of Trovafloxacin.Approved, Investigational, Withdrawn
TroxerutinSemapimod may increase the anticoagulant activities of Troxerutin.Investigational
Typhoid VaccineThe risk or severity of adverse effects can be increased when Semapimod is combined with Typhoid Vaccine.Approved
UlobetasolThe risk or severity of adverse effects can be increased when Semapimod is combined with Ulobetasol.Approved
UnoprostoneThe therapeutic efficacy of Unoprostone can be decreased when used in combination with Semapimod.Approved, Investigational
ValdecoxibThe risk or severity of adverse effects can be increased when Semapimod is combined with Valdecoxib.Approved, Investigational, Withdrawn
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Semapimod.Approved, Investigational
Varicella Zoster Vaccine (Live/Attenuated)The risk or severity of adverse effects can be increased when Semapimod is combined with Varicella Zoster Vaccine (Live/Attenuated).Approved
WarfarinSemapimod may increase the anticoagulant activities of Warfarin.Approved
XimelagatranSemapimod may increase the anticoagulant activities of Ximelagatran.Approved, Investigational, Withdrawn
Yellow Fever VaccineThe risk or severity of adverse effects can be increased when Semapimod is combined with Yellow Fever Vaccine.Approved, Investigational
ZaltoprofenThe risk or severity of adverse effects can be increased when Zaltoprofen is combined with Semapimod.Approved, Investigational
ZileutonThe risk or severity of adverse effects can be increased when Zileuton is combined with Semapimod.Approved, Investigational, Withdrawn
ZofenoprilThe risk or severity of adverse effects can be increased when Semapimod is combined with Zofenopril.Experimental
ZomepiracThe risk or severity of adverse effects can be increased when Zomepirac is combined with Semapimod.Withdrawn
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
5745214
PubChem Substance
347828398
ChemSpider
4676528
ChEMBL
CHEMBL2107779
Wikipedia
Semapimod

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableCrohn's Disease (CD)1
2CompletedTreatmentCrohn's Disease (CD)3
2TerminatedTreatmentCrohn's Disease (CD)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0377 mg/mLALOGPS
logP1.47ALOGPS
logP0.49ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)13.48ChemAxon
pKa (Strongest Basic)7.88ChemAxon
Physiological Charge3ChemAxon
Hydrogen Acceptor Count18ChemAxon
Hydrogen Donor Count14ChemAxon
Polar Surface Area355.24 Å2ChemAxon
Rotatable Bond Count19ChemAxon
Refractivity296.54 m3·mol-1ChemAxon
Polarizability83.66 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as anilides. These are organic heterocyclic compounds derived from oxoacids RkE(=O)l(OH)m (l not 0) by replacing an OH group by the NHPh group or derivative formed by ring substitution.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Anilides
Direct Parent
Anilides
Alternative Parents
N-arylamides / Fatty amides / Secondary carboxylic acid amides / Guanidines / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Anilide / N-arylamide / Fatty amide / Fatty acyl / Carboxamide group / Guanidine / Secondary carboxylic acid amide / Carboxylic acid derivative / Organooxygen compound / Organonitrogen compound
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 15:20 / Updated on August 02, 2018 06:33