Rhabdomyosarcomas

Also known as: Rhabdomyosarcoma / Rhabdosarcoma / Rhabdomyosarcoma NOS

DrugDrug NameDrug Description
DB00531CyclophosphamidePrecursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. [PubChem]
DB00970DactinomycinA compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
DB00762IrinotecanIrinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in October, 2015 (irinotecan liposome injection, trade name Onivyde).
DB00541VincristineVincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
DrugDrug NameTargetType
DB00531CyclophosphamideDNAtarget
DB00531CyclophosphamideCytochrome P450 2B6enzyme
DB00531CyclophosphamideCytochrome P450 2C9enzyme
DB00531CyclophosphamideCytochrome P450 3A4enzyme
DB00531CyclophosphamideCytochrome P450 2C19enzyme
DB00531CyclophosphamideCytochrome P450 2A6enzyme
DB00531CyclophosphamideCytochrome P450 2C18enzyme
DB00531CyclophosphamideCytochrome P450 2C8enzyme
DB00531CyclophosphamideCytochrome P450 3A5enzyme
DB00531CyclophosphamideNuclear receptor subfamily 1 group I member 2target
DB00970DactinomycinDNAtarget
DB00970DactinomycinSolute carrier family 22 member 5transporter
DB00970DactinomycinMultidrug resistance protein 1transporter
DB00970DactinomycinMultidrug resistance-associated protein 6transporter
DB00970DactinomycinMultidrug resistance-associated protein 1transporter
DB00970DactinomycinATP-binding cassette sub-family G member 2transporter
DB00970DactinomycinDNA topoisomerase 2target
DB00762IrinotecanDNA topoisomerase I, mitochondrialtarget
DB00762IrinotecanDNA topoisomerase 1target
DB00762IrinotecanCytochrome P450 3A4enzyme
DB00762IrinotecanCytochrome P450 3A5enzyme
DB00762IrinotecanUDP-glucuronosyltransferase 1-1enzyme
DB00762IrinotecanUDP-glucuronosyltransferase 1-9enzyme
DB00762IrinotecanLiver carboxylesterase 1enzyme
DB00762IrinotecanCytochrome P450 3A7enzyme
DB00762IrinotecanCytochrome P450 2B6enzyme
DB00762IrinotecanSolute carrier family 22 member 3transporter
DB00762IrinotecanSolute carrier organic anion transporter family member 1B1transporter
DB00762IrinotecanMultidrug resistance-associated protein 1transporter
DB00762IrinotecanATP-binding cassette sub-family G member 2transporter
DB00762IrinotecanSerum albumincarrier
DB00762IrinotecanCocaine esteraseenzyme
DB00762IrinotecanCholinesteraseenzyme
DB00762IrinotecanMultidrug resistance protein 1transporter
DB00762IrinotecanCanalicular multispecific organic anion transporter 1transporter
DB00541VincristineTubulin beta chaintarget
DB00541VincristineCytochrome P450 3A4enzyme
DB00541VincristineCytochrome P450 3A5enzyme
DB00541VincristineCytochrome P450 3A7enzyme
DB00541VincristineMultidrug resistance protein 1transporter
DB00541VincristineCanalicular multispecific organic anion transporter 2transporter
DB00541VincristineSolute carrier family 22 member 3transporter
DB00541VincristineMultidrug resistance-associated protein 1transporter
DB00541VincristineMultidrug resistance-associated protein 7transporter
DB00541VincristineCanalicular multispecific organic anion transporter 1transporter
DB00541VincristineBile salt export pumptransporter
DB00541VincristineATP-binding cassette sub-family G member 2transporter
DB00541VincristineTubulin alpha-4A chaintarget
DB00541VincristineRalA-binding protein 1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B3transporter
DrugDrug NamePhaseStatusCount
DB00531Cyclophosphamide0Recruiting1
DB01041Thalidomide0Recruiting1
DB00087Alemtuzumab1Active Not Recruiting1
DB01008Busulfan1Active Not Recruiting1
DB00515Cisplatin1Completed1
DB00531Cyclophosphamide1Recruiting2
DB00997Doxorubicin1Recruiting1
DB05847Doxorubicin1Recruiting1
DB01590Everolimus1Completed1
DB00099Filgrastim1Completed1
DB01073Fludarabine1Active Not Recruiting1
DB00762Irinotecan1Not Yet Recruiting1
DB00125L-Arginine1Active Not Recruiting1
DB01042Melphalan1Active Not Recruiting1
DB09073Palbociclib1Not Yet Recruiting1
DB00641Simvastatin1Recruiting1
DB00877Sirolimus1Active Not Recruiting2
DB12550Taladegib1Withdrawn1
DB00853Temozolomide1Not Yet Recruiting1
DB01030Topotecan1Recruiting1
DB00399Zoledronic acid1Recruiting1
DB08916Afatinib1 / 2Recruiting1
DB01254Dasatinib1 / 2Recruiting1
DB08871Eribulin1 / 2Recruiting1
DB12205Ganitumab1 / 2Recruiting1
DB00762Irinotecan1 / 2Recruiting1
DB01229Paclitaxel1 / 2Active Not Recruiting1
DB09143Sonidegib1 / 2Completed1
DB00112Bevacizumab2Recruiting1
DB12182Binetrakin2Completed1
DB08875Cabozantinib2Recruiting1
DB12250Cixutumumab2Completed2
DB00531Cyclophosphamide2Recruiting1
DB00970Dactinomycin2Recruiting1
DB01254Dasatinib2Active Not Recruiting1
DB00380Dexrazoxane2Completed1
DB00380Dexrazoxane2Recruiting1
DB00997Doxorubicin2Recruiting1
DB00530Erlotinib2Recruiting1
DB00773Etoposide2Recruiting1
DB00099Filgrastim2Recruiting1
DB00441Gemcitabine2Recruiting1
DB01645Genistein2Recruiting1
DB05036Grn163l2Withdrawn1
DB01181Ifosfamide2Recruiting1
DB00224Indinavir2Completed1
DB00762Irinotecan2Active Not Recruiting1
DB00762Irinotecan2Recruiting1
DB09136Isosulfan blue2Recruiting1
DB00125L-Arginine2Recruiting1
DB00134Methionine2Recruiting1
DB01229Paclitaxel2Recruiting1
DB00019Pegfilgrastim2Completed1
DB00019Pegfilgrastim2Recruiting1
DB00642Pemetrexed2Completed1
DB08896Regorafenib2Recruiting1
DB00020Sargramostim2Completed1
DB00398Sorafenib2Recruiting1
DB09266Technetium Tc-99m tilmanocept2Recruiting1
DB00853Temozolomide2Active Not Recruiting1
DB00853Temozolomide2Recruiting1
DB06287Temsirolimus2Completed1
DB01030Topotecan2Completed1
DB08881Vemurafenib2Recruiting1
DB00541Vincristine2Active Not Recruiting1
DB00541Vincristine2Recruiting1
DB00361Vinorelbine2Unknown Status1
DB00493Cefotaxime3Suspended1
DB00531Cyclophosphamide3Suspended1
DB00970Dactinomycin3Suspended1
DB00762Irinotecan3Suspended1
DB06287Temsirolimus3Suspended1
DB00541Vincristine3Suspended1
DB00531Cyclophosphamide4Unknown Status1
DB00997Doxorubicin4Unknown Status1
DB01008BusulfanNot AvailableRecruiting1
DB00958CarboplatinNot AvailableRecruiting1
DB09110Coenzyme MNot AvailableRecruiting1
DB00773EtoposideNot AvailableRecruiting1
DB06215FerumoxytolNot AvailableRecruiting1
DB01181IfosfamideNot AvailableRecruiting1
DB01042MelphalanNot AvailableRecruiting1
DB01229PaclitaxelNot AvailableRecruiting1
DB04572ThiotepaNot AvailableRecruiting1
DB01586Ursodeoxycholic acidNot AvailableRecruiting1