This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Epofolate
Accession Number
DB12266
Type
Small Molecule
Groups
Investigational
Description

Epofolate has been used in trials studying the treatment of Advanced Solid Tumors.

Synonyms
  • BMS-753493
Categories
UNII
Q3XAW4B1DP
CAS number
958646-17-8
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe serum concentration of (R)-warfarin can be increased when it is combined with Epofolate.
(S)-WarfarinThe serum concentration of (S)-Warfarin can be increased when it is combined with Epofolate.
3-isobutyl-1-methyl-7H-xanthineThe metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Epofolate.
3,5-diiodothyropropionic acidThe metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Epofolate.
4-hydroxycoumarinThe metabolism of 4-hydroxycoumarin can be decreased when combined with Epofolate.
5-androstenedioneThe metabolism of 5-androstenedione can be decreased when combined with Epofolate.
6-O-benzylguanineThe metabolism of 6-O-benzylguanine can be decreased when combined with Epofolate.
7-DeazaguanineThe metabolism of 7-Deazaguanine can be decreased when combined with Epofolate.
7,9-DimethylguanineThe metabolism of 7,9-Dimethylguanine can be decreased when combined with Epofolate.
8-azaguanineThe metabolism of 8-azaguanine can be decreased when combined with Epofolate.
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Substance
347911308

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2TerminatedTreatmentAdvanced Solid Tumors2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Kuper JI, D'Aprile M: Drug-Drug interactions of clinical significance in the treatment of patients with Mycobacterium avium complex disease. Clin Pharmacokinet. 2000 Sep;39(3):203-14. [PubMed:11020135]

Drug created on October 20, 2016 15:46 / Updated on November 02, 2018 07:22