Muplestim

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Muplestim
Accession Number
DB12431
Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Other protein based therapies
Description

Muplestim is under investigation in clinical trial NCT00002258 (A Phase I, Open Label Trial to Evaluate the Safety, Tolerance and Biological Effects of SDZ ILE-964 (Recombinant Human Interleukin-3, RhIL-3) in HIV Infected Patients With Cytopenia).

Protein chemical formula
Not Available
Protein average weight
Not Available
Sequences
Not Available
Synonyms
  • Human interleukin-3 (nonglycosylated)
  • Interleukin 3
  • Interleukin 3 (human)
  • Interleukin-3
  • Interleukin-3 human (recombinant)
  • Multipotential colony-stimulating factor
External IDs
Interleukin 3
Categories
UNII
A802907MI4
CAS number
148641-02-5

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
CyclophosphamideThe risk or severity of pulmonary toxicity can be increased when Muplestim is combined with Cyclophosphamide.
VinblastineThe risk or severity of peripheral neuropathy can be increased when Muplestim is combined with Vinblastine.
VincamineThe risk or severity of peripheral neuropathy can be increased when Muplestim is combined with Vincamine.
VincristineThe risk or severity of peripheral neuropathy can be increased when Muplestim is combined with Vincristine.
VindesineThe risk or severity of peripheral neuropathy can be increased when Muplestim is combined with Vindesine.
VinflunineThe risk or severity of peripheral neuropathy can be increased when Muplestim is combined with Vinflunine.
VinorelbineThe risk or severity of peripheral neuropathy can be increased when Muplestim is combined with Vinorelbine.
VintafolideThe risk or severity of peripheral neuropathy can be increased when Muplestim is combined with Vintafolide.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Substance
347911334

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentCytopenias / Human Immunodeficiency Virus (HIV) Infections1
1TerminatedSupportive CareMalignant Lymphomas / Neutropenias1
1, 2CompletedTreatmentCancer, Breast / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic/Myeloproliferative Diseases1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on October 20, 2016 16:22 / Updated on September 02, 2019 19:41