Glycoproteins

Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
DrugDrug NameDrug Description
DB00012Darbepoetin alfaA recombinant form of human erythropoietin used to increase differentiation of progenitor cells to red blood cells in the treatment of anemia.
DB00016ErythropoietinA recombinant form of human erythropoietin used to increase differentiation of progenitor cells to red blood cells in the treatment of anemia.
DB00019PegfilgrastimA modified form of recombinant human granulocyte colony stimulating factor used to induce production of granulocytes and lower infection risk after myelosuppressive therapy.
DB00020SargramostimA modified form of recombinant human granulocyte-macrophage colony stimulating factor used to increase immune cell production after myelosuppressive therapy or bone marrow transplant.
DB00055Drotrecogin alfaA form of recombinant activated human protein C used to reduce mortality in patients with severe sepsis by inhibiting coagulation Factors V and VIII.
DB00058Alpha-1-proteinase inhibitorA purified form of human alpha-1 proteinase inhibitor used to treat emphysema patients with associated alpha-1 proteinase inhibitor deficiency.
DB00099FilgrastimA form of recombinant human granulocyte colony stimulating factor used to induce the production of granulocytes and lower infection risk after myelosuppressive therapy.
DB01584ThyroglobulinFor the treatment of hypothyroidism (deficiency in the production of thyroid hormone).
DB05006AdecatumumabInvestigated for use/treatment in breast cancer and prostate cancer.
DB05332RomiplostimA fusion protein thrombopoietin (TPO) peptide analog that increases platelet counts by binding to and activating the human TPO receptor. Used to treat thrombocytopenia associated with chronic immune thrombocytopenia (ITP).
DB05718Maxy-G34Investigated for use/treatment in adverse effects (chemotherapy) and neutropenics.
DB05777Thrombomodulin AlfaInvestigated for use/treatment in blood preservative, blood (blood forming organ disorders, unspecified), sepsis and septicemia, and thrombosis.
DB05793PRO-542Investigated for use/treatment in acquired immune deficiency syndrome (AIDS) and aids-related infections, HIV infection, and pediatric indications.
DB05931PegdinetanibInvestigated for use/treatment in cancer/tumors (unspecified) and macular degeneration.
DB06404Human C1-esterase inhibitorA C1 inhibitor used to prevent angioedema attacks associated with hereditary angioedema.
DB06534ThrombopoietinInvestigated for use/treatment in thrombocytopenia.
DB06584TG4010Investigated for use/treatment in breast cancer, renal cell carcinoma, prostate cancer, and lung cancer.
DB09107Methoxy polyethylene glycol-epoetin betaA synthetic erythropoiesis stimulating agent (ESA) used to treat anemia associated with chronic kidney disease.
DB09349Gastric intrinsic factorIntrinsic factor is not currently available in any FDA or Health Canada approved products. However, it is currently in the marketed (but unapproved) product Hematogen in combination with cyanocobalamin (synthetic...
DB11312Protein CA medication used to treat protein C deficiency leading to purpura fulminans or coumarin-induced skin necrosis.
DB11624Epoetin deltaEpoetin Delta is an ingredient in the EMA-withdrawn product Dynepo.
DB12431MuplestimMuplestim is under investigation in clinical trial NCT00002258 (A Phase I, Open Label Trial to Evaluate the Safety, Tolerance and Biological Effects of SDZ ILE-964 (Recombinant Human Interleukin-3, RhIL-3) in...
DB12525MolgramostimMolgramostim has been used in trials studying the treatment of Bronchiectasis, Cystic Fibrosis, Pulmonary Alveolar Proteinosis, Acute Respiratory Distress Syndrome, and Autoimmune Pulmonary Alveolar Proteinosis.
DB12568TecemotideTecemotide has been used in trials studying the treatment of Prostate Cancer and Carcinoma, Non-Small-Cell Lung.
DB12699BalugrastimBalugrastim has been used in trials studying the treatment of Solid Tumors.
DB13144LenograstimThe drug is used to reduce the risk of life-threatening infection in patients with neutropenia, particularly after cytotoxic chemotherapy. Lenograstim is indicated as a treatment to reduce the duration of...
DB13149Protein S humanA medication used for emergency reversal of coagulation factor deficiency in vitamin K antagonist therapy.
DB13200LipegfilgrastimA medication used to reduce the duration of chemotherapy-induced neutropenia and incidence of febrile neutropenia in cytotoxic chemotherapy.
DB13257Ferrous sulfate anhydrousAn iron supplement used to prevent iron deficiency anemia.
DB13299SulglicotideNot Annotated
DB05386RegramostimInvestigated for use/treatment in adverse effects (chemotherapy) and bone marrow transplant.
DB14852PRM-151PRM-151 is under investigation in clinical trial NCT01981850 (A Phase 2 Study Of PRM-151 In Subjects With Myelofibrosis).
DB15015Recombinant CD40-ligandRecombinant CD40-ligand is under investigation in clinical trial NCT00053391 (Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma).
DB15095LeridistimLeridistim is under investigation in clinical trial NCT00004215 (Leridistim Compared With Filgrastim in Treating Older Patients With Acute Myeloid Leukemia).
DB15150FibronectinFibronectin is under investigation in clinical trial NCT01812239 (Vaginal Progesterone in Twins With Short Cervix).
DB15228AvidinAvidin is under investigation in clinical trial NCT00345618 (Clinical Study Assessing Idrabiotaparinux Sodium Injections Once-weekly in Pulmonary Embolism Therapeutic Approach).
DB00092AlefaceptA recombinant fusion protein that binds CD2 and is used treat moderate to severe plaque psoriasis.
DB12281LuspaterceptLuspatercept has been used in trials studying the treatment of Anemia, Beta-Thalassemia, Erythrocyte Transfusion, and Myelodysplastic Syndromes.
DB15366SOR-C13SOR-C13 is under investigation in clinical trial NCT01578564 (Safety and Tolerability Study of SOR-C13 in Subjects With Advanced Cancers Commonly Known to Express the TRPV6 Channel).
DrugDrug NameTargetType
DB00012Darbepoetin alfaErythropoietin receptortarget
DB00016ErythropoietinErythropoietin receptortarget
DB00019PegfilgrastimGranulocyte colony-stimulating factor receptortarget
DB00019PegfilgrastimNeutrophil elastasetarget
DB00020SargramostimGranulocyte-macrophage colony-stimulating factor receptor subunit alphatarget
DB00020SargramostimBone marrow proteoglycantarget
DB00020SargramostimInterleukin-3 receptor subunit alphatarget
DB00020SargramostimCytokine receptor common subunit betatarget
DB00020SargramostimSyndecan-2target
DB00055Drotrecogin alfaCoagulation factor VIIItarget
DB00055Drotrecogin alfaCoagulation factor Vtarget
DB00055Drotrecogin alfaPlasminogen activator inhibitor 1target
DB00055Drotrecogin alfaThrombomodulintarget
DB00055Drotrecogin alfaVitamin K-dependent protein Starget
DB00055Drotrecogin alfaCeruloplasmintarget
DB00055Drotrecogin alfaProthrombintarget
DB00055Drotrecogin alfaPlatelet factor 4target
DB00055Drotrecogin alfaPlasma serine protease inhibitortarget
DB00055Drotrecogin alfaSerpin B6target
DB00055Drotrecogin alfaVitamin K-dependent gamma-carboxylasetarget
DB00055Drotrecogin alfaEndothelial protein C receptortarget
DB00058Alpha-1-proteinase inhibitorNeutrophil elastasetarget
DB00099FilgrastimGranulocyte colony-stimulating factor receptortarget
DB00099FilgrastimNeutrophil elastasetarget
DB05332RomiplostimThrombopoietin receptortarget
DB05777Thrombomodulin AlfaCoagulation factor Vtarget
DB05777Thrombomodulin AlfaProthrombintarget
DB05793PRO-542Free fatty acid receptor 4target
DB05931PegdinetanibVascular endothelial growth factor receptor 2target
DB06404Human C1-esterase inhibitorComplement C1r subcomponenttarget
DB06404Human C1-esterase inhibitorComplement C1s subcomponenttarget
DB06404Human C1-esterase inhibitorPlasma kallikreintarget
DB06404Human C1-esterase inhibitorCoagulation factor XIItarget
DB06404Human C1-esterase inhibitorProthrombintarget
DB06404Human C1-esterase inhibitorCoagulation factor XItarget
DB06404Human C1-esterase inhibitorTissue-type plasminogen activatortarget
DB06534ThrombopoietinThrombopoietin receptortarget
DB06584TG4010Mucin-1target
DB06584TG4010Interleukin-2target
DB09107Methoxy polyethylene glycol-epoetin betaErythropoietin receptortarget
DB13144LenograstimGranulocyte colony-stimulating factor receptortarget
DB13149Protein S humanCoagulation factor Vtarget
DB13149Protein S humanCoagulation factor Xtarget
DB13149Protein S humanVitamin K-dependent protein Ctarget
DB13200LipegfilgrastimGranulocyte colony-stimulating factor receptortarget
DB13257Ferrous sulfate anhydrousSerotransferrintransporter
DB13257Ferrous sulfate anhydrousFerritin light chaintransporter
DB13257Ferrous sulfate anhydrousFerritin heavy chaintransporter
DB13257Ferrous sulfate anhydrousDivalent metal ion transporter 1transporter
DB13257Ferrous sulfate anhydrousIron binding protein FbpAtransporter
DB13257Ferrous sulfate anhydrousNADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialenzyme
DB13257Ferrous sulfate anhydrousSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialenzyme
DB13257Ferrous sulfate anhydrousXanthine dehydrogenase/oxidaseenzyme
DB13257Ferrous sulfate anhydrousAconitate hydratase, mitochondrialenzyme
DB13257Ferrous sulfate anhydrousCytochrome P450 4A11enzyme
DB13257Ferrous sulfate anhydrousSulfite oxidase, mitochondrialenzyme
DB13257Ferrous sulfate anhydrousMyeloperoxidaseenzyme
DB13257Ferrous sulfate anhydrousCatalaseenzyme
DB13257Ferrous sulfate anhydrousNitric oxide synthase, inducibleenzyme
DB13257Ferrous sulfate anhydrousProstaglandin G/H synthase 1enzyme
DB13257Ferrous sulfate anhydrousProstaglandin G/H synthase 2enzyme
DB13257Ferrous sulfate anhydrousTryptophan 5-hydroxylase 1enzyme
DB13257Ferrous sulfate anhydrousProlyl 4-hydroxylase subunit alpha-1enzyme
DB13257Ferrous sulfate anhydrousPterin-4-alpha-carbinolamine dehydrataseenzyme
DB13257Ferrous sulfate anhydrousCeruloplasminenzyme
DB13257Ferrous sulfate anhydrousFree radicalstarget
DB05386RegramostimGranulocyte-macrophage colony-stimulating factor receptor subunit alphatarget
DB05386RegramostimGM-CSF receptor alpha subunittarget
DB05386RegramostimCholinesteraseenzyme
DB00092AlefaceptT-cell surface antigen CD2target
DB00092AlefaceptLow affinity immunoglobulin gamma Fc region receptor III-Btarget
DB00092AlefaceptComplement C1r subcomponenttarget
DB00092AlefaceptComplement C1q subcomponent subunit Atarget
DB00092AlefaceptComplement C1q subcomponent subunit Btarget
DB00092AlefaceptComplement C1q subcomponent subunit Ctarget
DB00092AlefaceptLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB00092AlefaceptHigh affinity immunoglobulin gamma Fc receptor Itarget
DB00092AlefaceptLow affinity immunoglobulin gamma Fc region receptor II-atarget
DB00092AlefaceptLow affinity immunoglobulin gamma Fc region receptor II-btarget
DB00092AlefaceptLow affinity immunoglobulin gamma Fc region receptor II-ctarget