Troxerutin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Troxerutin
Accession Number
DB13124
Type
Small Molecule
Groups
Investigational
Description

Troxerutin has been used in trials studying the treatment of Chronic Venous Insufficiency.

Structure
Thumb
Synonyms
Not Available
Categories
UNII
7Y4N11PXO8
CAS number
7085-55-4
Weight
Average: 742.6752
Monoisotopic: 742.232029162
Chemical Formula
C33H42O19
InChI Key
IYVFNTXFRYQLRP-VVSTWUKXSA-N
InChI
InChI=1S/C33H42O19/c1-14-23(38)26(41)28(43)32(49-14)48-13-21-24(39)27(42)29(44)33(51-21)52-31-25(40)22-17(37)11-16(45-7-4-34)12-20(22)50-30(31)15-2-3-18(46-8-5-35)19(10-15)47-9-6-36/h2-3,10-12,14,21,23-24,26-29,32-39,41-44H,4-9,13H2,1H3/t14-,21+,23-,24+,26+,27-,28+,29+,32+,33-/m0/s1
IUPAC Name
2-[3,4-bis(2-hydroxyethoxy)phenyl]-5-hydroxy-7-(2-hydroxyethoxy)-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-4H-chromen-4-one
SMILES
C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](OC3=C(OC4=CC(OCCO)=CC(O)=C4C3=O)C3=CC(OCCO)=C(OCCO)C=C3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limonene(4R)-limonene may increase the anticoagulant activities of Troxerutin.Investigational
AbciximabAbciximab may increase the anticoagulant activities of Troxerutin.Approved
AceclofenacAceclofenac may increase the anticoagulant activities of Troxerutin.Approved, Investigational
AcemetacinThe risk or severity of bleeding can be increased when Troxerutin is combined with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolAcenocoumarol may increase the anticoagulant activities of Troxerutin.Approved, Investigational
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Troxerutin.Approved, Vet Approved
AdapaleneAdapalene may increase the anticoagulant activities of Troxerutin.Approved
AlclofenacAlclofenac may increase the anticoagulant activities of Troxerutin.Approved, Withdrawn
AllylestrenolThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Allylestrenol.Approved
AlminoprofenAlminoprofen may increase the anticoagulant activities of Troxerutin.Experimental
AloxiprinAloxiprin may increase the anticoagulant activities of Troxerutin.Experimental
AlprostadilAlprostadil may increase the anticoagulant activities of Troxerutin.Approved, Investigational
AlteplaseAlteplase may increase the anticoagulant activities of Troxerutin.Approved
AltrenogestThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Altrenogest.Vet Approved
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Troxerutin.Approved
AnagrelideAnagrelide may increase the anticoagulant activities of Troxerutin.Approved
AncrodAncrod may increase the anticoagulant activities of Troxerutin.Approved, Investigational
AndrographolideAndrographolide may increase the anticoagulant activities of Troxerutin.Investigational
AnisodamineAnisodamine may increase the anticoagulant activities of Troxerutin.Investigational
AnistreplaseAnistreplase may increase the anticoagulant activities of Troxerutin.Approved
AntipyrineAntipyrine may increase the anticoagulant activities of Troxerutin.Approved, Investigational
Antithrombin III humanAntithrombin III human may increase the anticoagulant activities of Troxerutin.Approved
ApixabanApixaban may increase the anticoagulant activities of Troxerutin.Approved
ApocyninApocynin may increase the anticoagulant activities of Troxerutin.Investigational
ApremilastApremilast may increase the anticoagulant activities of Troxerutin.Approved, Investigational
ArdeparinArdeparin may increase the anticoagulant activities of Troxerutin.Approved, Investigational, Withdrawn
ArgatrobanArgatroban may increase the anticoagulant activities of Troxerutin.Approved, Investigational
AstaxanthinAstaxanthin may increase the anticoagulant activities of Troxerutin.Investigational
AzapropazoneAzapropazone may increase the anticoagulant activities of Troxerutin.Withdrawn
AzelastineAzelastine may increase the anticoagulant activities of Troxerutin.Approved
Azficel-TThe risk or severity of adverse effects can be increased when Troxerutin is combined with Azficel-T.Approved, Investigational
BalsalazideBalsalazide may increase the anticoagulant activities of Troxerutin.Approved, Investigational
BatroxobinBatroxobin may increase the anticoagulant activities of Troxerutin.Experimental
BazedoxifeneBazedoxifene may decrease the anticoagulant activities of Troxerutin.Approved, Investigational
BecaplerminBecaplermin may increase the anticoagulant activities of Troxerutin.Approved, Investigational
BemiparinBemiparin may increase the anticoagulant activities of Troxerutin.Approved, Investigational
BendazacBendazac may increase the anticoagulant activities of Troxerutin.Experimental
BenorilateBenorilate may increase the anticoagulant activities of Troxerutin.Experimental
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Troxerutin.Withdrawn
BenzydamineBenzydamine may increase the anticoagulant activities of Troxerutin.Approved
BeraprostBeraprost may increase the anticoagulant activities of Troxerutin.Investigational
BevoniumBevonium may increase the anticoagulant activities of Troxerutin.Experimental
BivalirudinBivalirudin may increase the anticoagulant activities of Troxerutin.Approved, Investigational
BrinaseBrinase may increase the anticoagulant activities of Troxerutin.Experimental
BromfenacBromfenac may increase the anticoagulant activities of Troxerutin.Approved
BucillamineBucillamine may increase the anticoagulant activities of Troxerutin.Investigational
BufexamacBufexamac may increase the anticoagulant activities of Troxerutin.Approved, Experimental
BuflomedilBuflomedil may increase the anticoagulant activities of Troxerutin.Experimental
BumadizoneBumadizone may increase the anticoagulant activities of Troxerutin.Experimental
ButylphthalideButylphthalide may increase the anticoagulant activities of Troxerutin.Investigational
CangrelorCangrelor may increase the anticoagulant activities of Troxerutin.Approved
CaplacizumabCaplacizumab may increase the anticoagulant activities of Troxerutin.Investigational
Carbaspirin calciumCarbaspirin calcium may increase the anticoagulant activities of Troxerutin.Experimental, Investigational
CarprofenCarprofen may increase the anticoagulant activities of Troxerutin.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may increase the anticoagulant activities of Troxerutin.Experimental
CelecoxibCelecoxib may increase the anticoagulant activities of Troxerutin.Approved, Investigational
CertoparinCertoparin may increase the anticoagulant activities of Troxerutin.Approved, Investigational
ChlormadinoneThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Chlormadinone.Experimental
ChloroquineChloroquine may increase the anticoagulant activities of Troxerutin.Approved, Investigational, Vet Approved
ChlorotrianiseneChlorotrianisene may decrease the anticoagulant activities of Troxerutin.Investigational, Withdrawn
Choline magnesium trisalicylateCholine magnesium trisalicylate may increase the anticoagulant activities of Troxerutin.Approved
Citric AcidCitric Acid may increase the anticoagulant activities of Troxerutin.Approved, Nutraceutical, Vet Approved
ClonixinClonixin may increase the anticoagulant activities of Troxerutin.Approved
ClopidogrelClopidogrel may increase the anticoagulant activities of Troxerutin.Approved
CloricromenCloricromen may increase the anticoagulant activities of Troxerutin.Experimental
ClorindioneClorindione may increase the anticoagulant activities of Troxerutin.Experimental
Collagenase clostridium histolyticumThe risk or severity of adverse effects can be increased when Troxerutin is combined with Collagenase clostridium histolyticum.Approved, Investigational
Conjugated estrogensConjugated estrogens may decrease the anticoagulant activities of Troxerutin.Approved
CurcuminCurcumin may increase the anticoagulant activities of Troxerutin.Approved, Investigational
Dabigatran etexilateDabigatran etexilate may increase the anticoagulant activities of Troxerutin.Approved
DaidzeinDaidzein may decrease the anticoagulant activities of Troxerutin.Experimental
DalteparinDalteparin may increase the anticoagulant activities of Troxerutin.Approved
DanaparoidDanaparoid may increase the anticoagulant activities of Troxerutin.Approved, Withdrawn
DarexabanDarexaban may increase the anticoagulant activities of Troxerutin.Investigational
DasatinibDasatinib may increase the anticoagulant activities of Troxerutin.Approved, Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Troxerutin is combined with Deferasirox.Approved, Investigational
DefibrotideDefibrotide may increase the anticoagulant activities of Troxerutin.Approved, Investigational
DemegestoneThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Demegestone.Approved
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Troxerutin is combined with Deoxycholic Acid.Approved
DersalazineDersalazine may increase the anticoagulant activities of Troxerutin.Investigational
DesirudinDesirudin may increase the anticoagulant activities of Troxerutin.Approved
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Troxerutin.Investigational
DesogestrelThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Desogestrel.Approved
DesvenlafaxineDesvenlafaxine may increase the antiplatelet activities of Troxerutin.Approved, Investigational
DextranDextran may increase the anticoagulant activities of Troxerutin.Approved, Investigational, Vet Approved
DiclofenacDiclofenac may increase the anticoagulant activities of Troxerutin.Approved, Vet Approved
DicoumarolDicoumarol may increase the anticoagulant activities of Troxerutin.Approved
DienestrolDienestrol may decrease the anticoagulant activities of Troxerutin.Approved, Investigational
DienogestThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Dienogest.Approved
DiethylstilbestrolDiethylstilbestrol may decrease the anticoagulant activities of Troxerutin.Approved, Investigational
DifenpiramideDifenpiramide may increase the anticoagulant activities of Troxerutin.Experimental
DiflunisalDiflunisal may increase the anticoagulant activities of Troxerutin.Approved, Investigational
DiphenadioneDiphenadione may increase the anticoagulant activities of Troxerutin.Experimental
DipyridamoleDipyridamole may increase the anticoagulant activities of Troxerutin.Approved
DitazoleDitazole may increase the anticoagulant activities of Troxerutin.Approved, Withdrawn
DrospirenoneThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Drospirenone.Approved
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Troxerutin.Approved, Investigational, Withdrawn
DroxicamDroxicam may increase the anticoagulant activities of Troxerutin.Withdrawn
DuvelisibDuvelisib may increase the anticoagulant activities of Troxerutin.Investigational
DydrogesteroneThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Dydrogesterone.Approved, Investigational, Withdrawn
E-6201E-6201 may increase the anticoagulant activities of Troxerutin.Investigational
Edetic AcidEdetic Acid may increase the anticoagulant activities of Troxerutin.Approved, Vet Approved
EdoxabanEdoxaban may increase the anticoagulant activities of Troxerutin.Approved
EnoxaparinEnoxaparin may increase the anticoagulant activities of Troxerutin.Approved
EpimestrolEpimestrol may decrease the anticoagulant activities of Troxerutin.Experimental
EpinastineEpinastine may increase the anticoagulant activities of Troxerutin.Approved, Investigational
EpirizoleEpirizole may increase the anticoagulant activities of Troxerutin.Approved
EplivanserinEplivanserin may increase the anticoagulant activities of Troxerutin.Investigational
eplivanserineeplivanserine may increase the anticoagulant activities of Troxerutin.Investigational
EpoprostenolEpoprostenol may increase the anticoagulant activities of Troxerutin.Approved
EptifibatideEptifibatide may increase the anticoagulant activities of Troxerutin.Approved, Investigational
EquolEquol may decrease the anticoagulant activities of Troxerutin.Investigational
EstradiolEstradiol may decrease the anticoagulant activities of Troxerutin.Approved, Investigational, Vet Approved
Estradiol acetateEstradiol acetate may decrease the anticoagulant activities of Troxerutin.Approved, Investigational, Vet Approved
Estradiol cypionateEstradiol cypionate may decrease the anticoagulant activities of Troxerutin.Approved, Investigational, Vet Approved
Estradiol valerateEstradiol valerate may decrease the anticoagulant activities of Troxerutin.Approved, Investigational, Vet Approved
EstriolEstriol may decrease the anticoagulant activities of Troxerutin.Approved, Investigational, Vet Approved
Estrogens, esterifiedEstrogens, esterified may decrease the anticoagulant activities of Troxerutin.Approved
EstroneEstrone may decrease the anticoagulant activities of Troxerutin.Approved
EtanerceptEtanercept may increase the anticoagulant activities of Troxerutin.Approved, Investigational
EthenzamideEthenzamide may increase the anticoagulant activities of Troxerutin.Experimental
Ethinyl EstradiolEthinyl Estradiol may decrease the anticoagulant activities of Troxerutin.Approved
Ethyl biscoumacetateEthyl biscoumacetate may increase the anticoagulant activities of Troxerutin.Withdrawn
EthynodiolThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Ethynodiol.Experimental
EtodolacEtodolac may increase the anticoagulant activities of Troxerutin.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may increase the anticoagulant activities of Troxerutin.Approved, Investigational
EtonogestrelThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Etonogestrel.Approved, Investigational
EtoricoxibEtoricoxib may increase the anticoagulant activities of Troxerutin.Approved, Investigational
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Troxerutin.Investigational, Nutraceutical
ExisulindExisulind may increase the anticoagulant activities of Troxerutin.Investigational
FelbinacFelbinac may increase the anticoagulant activities of Troxerutin.Experimental
FenbufenFenbufen may increase the anticoagulant activities of Troxerutin.Approved
FenoprofenFenoprofen may increase the anticoagulant activities of Troxerutin.Approved
FentiazacFentiazac may increase the anticoagulant activities of Troxerutin.Experimental
FeprazoneFeprazone may increase the anticoagulant activities of Troxerutin.Experimental
Ferulic acidFerulic acid may increase the anticoagulant activities of Troxerutin.Experimental
FibrinolysinFibrinolysin may increase the anticoagulant activities of Troxerutin.Investigational
FloctafenineFloctafenine may increase the anticoagulant activities of Troxerutin.Approved, Withdrawn
FluindioneTroxerutin may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlunixinFlunixin may increase the anticoagulant activities of Troxerutin.Vet Approved
FlunoxaprofenFlunoxaprofen may increase the anticoagulant activities of Troxerutin.Experimental
FluoxetineFluoxetine may increase the antiplatelet activities of Troxerutin.Approved, Vet Approved
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Troxerutin.Approved, Investigational
FondaparinuxFondaparinux sodium may increase the anticoagulant activities of Troxerutin.Approved, Investigational
GabexateGabexate may increase the anticoagulant activities of Troxerutin.Investigational
GenisteinGenistein may decrease the anticoagulant activities of Troxerutin.Investigational
GestodeneThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Gestodene.Approved, Investigational
GestonoroneThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Gestonorone.Experimental
GestrinoneThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Gestrinone.Approved
GuacetisalGuacetisal may increase the anticoagulant activities of Troxerutin.Experimental
HeminHemin may increase the anticoagulant activities of Troxerutin.Approved, Investigational
Hemoglobin crosfumarilHemoglobin crosfumaril may increase the anticoagulant activities of Troxerutin.Experimental
HeparinHeparin may increase the anticoagulant activities of Troxerutin.Approved, Investigational
HexestrolHexestrol may decrease the anticoagulant activities of Troxerutin.Withdrawn
HigenamineHigenamine may increase the anticoagulant activities of Troxerutin.Investigational
Hydroxyprogesterone caproateThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Hydroxyprogesterone caproate.Approved, Investigational
HydroxytyrosolHydroxytyrosol may increase the anticoagulant activities of Troxerutin.Investigational
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Troxerutin is combined with Ibritumomab tiuxetan.Approved, Investigational
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Troxerutin.Approved
IbudilastIbudilast may increase the anticoagulant activities of Troxerutin.Approved, Investigational
IbuprofenThe risk or severity of bleeding and hemorrhage can be increased when Ibuprofen is combined with Troxerutin.Approved
IbuproxamIbuproxam may increase the anticoagulant activities of Troxerutin.Withdrawn
IcatibantIcatibant may increase the anticoagulant activities of Troxerutin.Approved, Investigational
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Troxerutin.Approved, Investigational, Nutraceutical
IdraparinuxIdraparinux may increase the anticoagulant activities of Troxerutin.Investigational
IfenprodilIfenprodil may increase the anticoagulant activities of Troxerutin.Approved, Investigational, Withdrawn
IfetrobanIfetroban may increase the anticoagulant activities of Troxerutin.Investigational
IloprostIloprost may increase the anticoagulant activities of Troxerutin.Approved, Investigational
Imidazole salicylateImidazole salicylate may increase the anticoagulant activities of Troxerutin.Experimental
IndobufenIndobufen may increase the anticoagulant activities of Troxerutin.Investigational
IndomethacinIndomethacin may increase the anticoagulant activities of Troxerutin.Approved, Investigational
IndoprofenIndoprofen may increase the anticoagulant activities of Troxerutin.Withdrawn
IsoxicamIsoxicam may increase the anticoagulant activities of Troxerutin.Withdrawn
KebuzoneKebuzone may increase the anticoagulant activities of Troxerutin.Experimental
KetanserinKetanserin may increase the anticoagulant activities of Troxerutin.Investigational
KetoprofenKetoprofen may increase the anticoagulant activities of Troxerutin.Approved, Vet Approved
KetorolacKetorolac may increase the anticoagulant activities of Troxerutin.Approved
LeflunomideLeflunomide may increase the anticoagulant activities of Troxerutin.Approved, Investigational
LepirudinTroxerutin may increase the anticoagulant activities of Lepirudin.Approved
LetaxabanLetaxaban may increase the anticoagulant activities of Troxerutin.Investigational
LevonorgestrelThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Levonorgestrel.Approved, Investigational
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Troxerutin.Approved, Investigational
LinsidomineLinsidomine may increase the anticoagulant activities of Troxerutin.Experimental
LisofyllineLisofylline may increase the anticoagulant activities of Troxerutin.Investigational
LonazolacLonazolac may increase the anticoagulant activities of Troxerutin.Experimental
LornoxicamLornoxicam may increase the anticoagulant activities of Troxerutin.Approved, Investigational
LoxoprofenLoxoprofen may increase the anticoagulant activities of Troxerutin.Approved, Investigational
LumiracoxibLumiracoxib may increase the anticoagulant activities of Troxerutin.Approved, Investigational
LynestrenolThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Lynestrenol.Approved, Investigational
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Troxerutin.Approved
MasoprocolMasoprocol may increase the anticoagulant activities of Troxerutin.Approved, Investigational
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Troxerutin.Approved, Vet Approved
MedrogestoneThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Medrogestone.Approved
Medroxyprogesterone acetateThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Medroxyprogesterone acetate.Approved, Investigational
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Troxerutin.Approved
Megestrol acetateThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Megestrol acetate.Approved, Investigational, Vet Approved
MelagatranTroxerutin may increase the anticoagulant activities of Melagatran.Experimental
MeloxicamMeloxicam may increase the anticoagulant activities of Troxerutin.Approved, Vet Approved
MesalazineMesalazine may increase the anticoagulant activities of Troxerutin.Approved
MestranolMestranol may decrease the anticoagulant activities of Troxerutin.Approved
MetamizoleMetamizole may increase the anticoagulant activities of Troxerutin.Approved, Investigational, Withdrawn
MethallenestrilMethallenestril may decrease the anticoagulant activities of Troxerutin.Experimental
Methyl salicylateMethyl salicylate may increase the anticoagulant activities of Troxerutin.Approved, Vet Approved
MethylestrenoloneThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Methylestrenolone.Experimental
MilrinoneMilrinone may increase the anticoagulant activities of Troxerutin.Approved
MizoribineMizoribine may increase the anticoagulant activities of Troxerutin.Investigational
MofebutazoneMofebutazone may increase the anticoagulant activities of Troxerutin.Experimental
MoxestrolMoxestrol may decrease the anticoagulant activities of Troxerutin.Experimental
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Troxerutin.Approved, Investigational
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Troxerutin.Approved
NabumetoneNabumetone may increase the anticoagulant activities of Troxerutin.Approved
NadroparinNadroparin may increase the anticoagulant activities of Troxerutin.Approved, Investigational
NafamostatNafamostat may increase the anticoagulant activities of Troxerutin.Approved, Investigational
NaftifineNaftifine may increase the anticoagulant activities of Troxerutin.Approved
NaftopidilNaftopidil may increase the anticoagulant activities of Troxerutin.Investigational
NaproxenNaproxen may increase the anticoagulant activities of Troxerutin.Approved, Vet Approved
NepafenacNepafenac may increase the anticoagulant activities of Troxerutin.Approved, Investigational
NifenazoneNifenazone may increase the anticoagulant activities of Troxerutin.Experimental
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Troxerutin.Approved
NimesulideNimesulide may increase the anticoagulant activities of Troxerutin.Approved, Investigational, Withdrawn
NintedanibThe risk or severity of adverse effects can be increased when Troxerutin is combined with Nintedanib.Approved
NitroaspirinNitroaspirin may increase the anticoagulant activities of Troxerutin.Investigational
NomegestrolThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Nomegestrol.Approved
NorethisteroneThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Norethisterone.Approved
NorgestrienoneThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Norgestrienone.Experimental
ObinutuzumabThe risk or severity of adverse effects can be increased when Troxerutin is combined with Obinutuzumab.Approved, Investigational
OlopatadineOlopatadine may increase the anticoagulant activities of Troxerutin.Approved
OlsalazineOlsalazine may increase the anticoagulant activities of Troxerutin.Approved
Omacetaxine mepesuccinateThe risk or severity of bleeding can be increased when Troxerutin is combined with Omacetaxine mepesuccinate.Approved, Investigational
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Troxerutin.Approved, Nutraceutical
Omega-3-carboxylic acidsThe therapeutic efficacy of Troxerutin can be increased when used in combination with Omega-3-carboxylic acids.Approved, Investigational
OrgoteinOrgotein may increase the anticoagulant activities of Troxerutin.Vet Approved
OtamixabanOtamixaban may increase the anticoagulant activities of Troxerutin.Investigational
OxaprozinOxaprozin may increase the anticoagulant activities of Troxerutin.Approved
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Troxerutin.Approved, Withdrawn
OzagrelOzagrel may increase the anticoagulant activities of Troxerutin.Investigational
PalmidrolPalmidrol may increase the anticoagulant activities of Troxerutin.Experimental, Nutraceutical
ParecoxibParecoxib may increase the anticoagulant activities of Troxerutin.Approved
ParthenolideParthenolide may increase the anticoagulant activities of Troxerutin.Approved, Investigational
Pentaerythritol TetranitratePentaerythritol Tetranitrate may increase the anticoagulant activities of Troxerutin.Approved
Pentosan PolysulfatePentosan Polysulfate may increase the anticoagulant activities of Troxerutin.Approved
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Troxerutin.Approved, Investigational
PhenindionePhenindione may increase the anticoagulant activities of Troxerutin.Approved, Investigational
PhenprocoumonPhenprocoumon may increase the anticoagulant activities of Troxerutin.Approved, Investigational
Phenyl aminosalicylatePhenyl aminosalicylate may increase the anticoagulant activities of Troxerutin.Approved
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Troxerutin.Approved, Vet Approved
PicotamidePicotamide may increase the anticoagulant activities of Troxerutin.Experimental
PimecrolimusPimecrolimus may increase the anticoagulant activities of Troxerutin.Approved, Investigational
PirfenidonePirfenidone may increase the anticoagulant activities of Troxerutin.Approved, Investigational
PiroxicamPiroxicam may increase the anticoagulant activities of Troxerutin.Approved, Investigational
PirprofenPirprofen may increase the anticoagulant activities of Troxerutin.Experimental
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Troxerutin.Approved
Potassium CitrateTroxerutin may increase the anticoagulant activities of Potassium Citrate.Approved, Investigational, Vet Approved
PranoprofenPranoprofen may increase the anticoagulant activities of Troxerutin.Experimental, Investigational
PrasugrelPrasugrel may increase the anticoagulant activities of Troxerutin.Approved
ProgesteroneThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Progesterone.Approved, Vet Approved
ProglumetacinProglumetacin may increase the anticoagulant activities of Troxerutin.Experimental
PromegestoneThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Promegestone.Experimental
PromestrienePromestriene may decrease the anticoagulant activities of Troxerutin.Investigational
PropacetamolPropacetamol may increase the anticoagulant activities of Troxerutin.Approved, Investigational
PropyphenazonePropyphenazone may increase the anticoagulant activities of Troxerutin.Experimental
ProquazoneProquazone may increase the anticoagulant activities of Troxerutin.Experimental
Protein CProtein C may increase the anticoagulant activities of Troxerutin.Approved
Protein S humanTroxerutin may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeProtocatechualdehyde may increase the anticoagulant activities of Troxerutin.Approved
PTC299PTC299 may increase the anticoagulant activities of Troxerutin.Investigational
QuinestrolQuinestrol may decrease the anticoagulant activities of Troxerutin.Approved
QuingestanolThe therapeutic efficacy of Troxerutin can be decreased when used in combination with Quingestanol.Experimental
RamatrobanRamatroban may increase the anticoagulant activities of Troxerutin.Investigational
RelcovaptanRelcovaptan may increase the anticoagulant activities of Troxerutin.Investigational
ResveratrolResveratrol may increase the anticoagulant activities of Troxerutin.Approved, Experimental, Investigational
ReteplaseReteplase may increase the anticoagulant activities of Troxerutin.Approved, Investigational
ReviparinReviparin may increase the anticoagulant activities of Troxerutin.Approved, Investigational
RidogrelRidogrel may increase the anticoagulant activities of Troxerutin.Approved
RivaroxabanTroxerutin may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibRofecoxib may increase the anticoagulant activities of Troxerutin.Approved, Investigational, Withdrawn
RosiglitazoneRosiglitazone may increase the anticoagulant activities of Troxerutin.Approved, Investigational
SalicylamideSalicylamide may increase the anticoagulant activities of Troxerutin.Approved
Salicylic acidSalicylic acid may increase the anticoagulant activities of Troxerutin.Approved, Investigational, Vet Approved
SalsalateSalsalate may increase the anticoagulant activities of Troxerutin.Approved
SarpogrelateSarpogrelate may increase the anticoagulant activities of Troxerutin.Investigational
SecoisolariciresinolSecoisolariciresinol may decrease the anticoagulant activities of Troxerutin.Investigational
SelexipagSelexipag may increase the anticoagulant activities of Troxerutin.Approved
SemapimodSemapimod may increase the anticoagulant activities of Troxerutin.Investigational
SeratrodastSeratrodast may increase the anticoagulant activities of Troxerutin.Approved
SerrapeptaseSerrapeptase may increase the anticoagulant activities of Troxerutin.Investigational
SevofluraneSevoflurane may increase the anticoagulant activities of Troxerutin.Approved, Vet Approved
Sodium CitrateTroxerutin may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
SRT501SRT501 may increase the anticoagulant activities of Troxerutin.Investigational
StreptokinaseStreptokinase may increase the anticoagulant activities of Troxerutin.Approved, Investigational
SugammadexSugammadex may increase the anticoagulant activities of Troxerutin.Approved
SulfasalazineSulfasalazine may increase the anticoagulant activities of Troxerutin.Approved
SulindacSulindac may increase the anticoagulant activities of Troxerutin.Approved, Investigational
SulodexideSulodexide may increase the anticoagulant activities of Troxerutin.Approved, Investigational
SuprofenSuprofen may increase the anticoagulant activities of Troxerutin.Approved, Withdrawn
SuxibuzoneSuxibuzone may increase the anticoagulant activities of Troxerutin.Experimental
Synthetic Conjugated Estrogens, ASynthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Troxerutin.Approved
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Troxerutin.Approved
TarenflurbilTarenflurbil may increase the anticoagulant activities of Troxerutin.Investigational
TenecteplaseTenecteplase may increase the anticoagulant activities of Troxerutin.Approved
TenidapTenidap may increase the anticoagulant activities of Troxerutin.Experimental
TenoxicamTenoxicam may increase the anticoagulant activities of Troxerutin.Approved
TepoxalinTepoxalin may increase the anticoagulant activities of Troxerutin.Vet Approved
TeriflunomideTeriflunomide may increase the anticoagulant activities of Troxerutin.Approved
TesmilifeneTesmilifene may increase the anticoagulant activities of Troxerutin.Investigational
Testosterone cypionateThe therapeutic efficacy of Troxerutin can be increased when used in combination with Testosterone cypionate.Approved
Testosterone enanthateThe therapeutic efficacy of Troxerutin can be increased when used in combination with Testosterone enanthate.Approved
Testosterone undecanoateThe therapeutic efficacy of Troxerutin can be increased when used in combination with Testosterone undecanoate.Approved, Investigational
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Troxerutin.Approved
TiboloneTibolone may increase the anticoagulant activities of Troxerutin.Approved, Investigational
TicagrelorTicagrelor may increase the anticoagulant activities of Troxerutin.Approved
TiclopidineTiclopidine may increase the anticoagulant activities of Troxerutin.Approved
TinoridineTinoridine may increase the anticoagulant activities of Troxerutin.Investigational
TinzaparinTinzaparin may increase the anticoagulant activities of Troxerutin.Approved
TioclomarolTioclomarol may increase the anticoagulant activities of Troxerutin.Experimental
TipranavirTipranavir may increase the anticoagulant activities of Troxerutin.Approved, Investigational
TirofibanTirofiban may increase the anticoagulant activities of Troxerutin.Approved
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Troxerutin.Approved, Investigational
TolmetinTolmetin may increase the anticoagulant activities of Troxerutin.Approved
TositumomabThe risk or severity of adverse effects can be increased when Troxerutin is combined with Tositumomab.Approved, Investigational
TranilastTranilast may increase the anticoagulant activities of Troxerutin.Approved, Investigational
TrapidilTrapidil may increase the anticoagulant activities of Troxerutin.Approved
TreprostinilTreprostinil may increase the anticoagulant activities of Troxerutin.Approved, Investigational
TribenosideTribenoside may increase the anticoagulant activities of Troxerutin.Experimental
TriflusalTriflusal may increase the anticoagulant activities of Troxerutin.Approved, Investigational
TriptolideTriptolide may increase the anticoagulant activities of Troxerutin.Investigational
Trolamine salicylateTrolamine salicylate may increase the anticoagulant activities of Troxerutin.Approved
UrokinaseUrokinase may increase the anticoagulant activities of Troxerutin.Approved, Investigational, Withdrawn
ValdecoxibValdecoxib may increase the anticoagulant activities of Troxerutin.Approved, Investigational, Withdrawn
VenlafaxineVenlafaxine may increase the antiplatelet activities of Troxerutin.Approved
Vitamin EVitamin E may increase the anticoagulant activities of Troxerutin.Approved, Nutraceutical, Vet Approved
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Troxerutin.Approved
WarfarinWarfarin may increase the anticoagulant activities of Troxerutin.Approved
XimelagatranXimelagatran may increase the anticoagulant activities of Troxerutin.Approved, Investigational, Withdrawn
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Troxerutin.Approved, Investigational
ZeranolZeranol may decrease the anticoagulant activities of Troxerutin.Vet Approved
ZileutonZileuton may increase the anticoagulant activities of Troxerutin.Approved, Investigational, Withdrawn
ZomepiracZomepirac may increase the anticoagulant activities of Troxerutin.Withdrawn
Food Interactions
Not Available

References

General References
Not Available
External Links
Human Metabolome Database
HMDB0006083
PubChem Compound
5486699
PubChem Substance
347829247
ChemSpider
4589027
ChEMBL
CHEMBL3182320
Wikipedia
Troxerutin
ATC Codes
C05CA04 — TroxerutinC05CA54 — Troxerutin, combinations

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentChronic Venous Insufficiency (CVI)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility1.43 mg/mLALOGPS
logP-0.55ALOGPS
logP-2.5ChemAxon
logS-2.7ALOGPS
pKa (Strongest Acidic)8.34ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count19ChemAxon
Hydrogen Donor Count10ChemAxon
Polar Surface Area293.21 Å2ChemAxon
Rotatable Bond Count15ChemAxon
Refractivity172.47 m3·mol-1ChemAxon
Polarizability73.12 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as flavonoid-3-o-glycosides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C3-position.
Kingdom
Organic compounds
Super Class
Phenylpropanoids and polyketides
Class
Flavonoids
Sub Class
Flavonoid glycosides
Direct Parent
Flavonoid-3-O-glycosides
Alternative Parents
5-hydroxyflavonoids / Flavones / Chromones / Disaccharides / O-glycosyl compounds / Phenoxy compounds / Phenol ethers / 1-hydroxy-4-unsubstituted benzenoids / 1-hydroxy-2-unsubstituted benzenoids / Alkyl aryl ethers
show 11 more
Substituents
Flavonoid-3-o-glycoside / 5-hydroxyflavonoid / Hydroxyflavonoid / Flavone / O-glycosyl compound / Glycosyl compound / Chromone / Disaccharide / Benzopyran / 1-benzopyran
show 25 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 21:27 / Updated on August 02, 2018 06:48