Hemorrhoids

Also known as: HEMORRHOIDS / Hemorrhoid / Haemorrhoids / Piles / Hemorrhoids and perianal venous thrombosis

DrugDrug NameDrug Description
DB01086BenzocaineA surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. [PubChem]
DB00527CinchocaineA local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
DB11578Hard fatNot Available
DB14539Hydrocortisone acetateNot Available
DB00388PhenylephrinePhenylephrine is a sympathomimetic amine that acts predominantly on α-adrenergic receptors. It is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs.
DB09345PramocainePramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders. Pramocaine is available by itself and in combination with other medications in various topical preparations. It works by preventing ionic fluctuations needed for neuron membrane depolarization and action potential propagation.
DrugDrug NameTargetType
DB01086BenzocaineSodium channel protein type 10 subunit alphatarget
DB01086BenzocaineMultidrug resistance protein 1transporter
DB01086BenzocaineLiver carboxylesterase 1enzyme
DB00527CinchocaineSodium channel protein type 5 subunit alphatarget
DB00527CinchocaineSodium channel protein type 10 subunit alphatarget
DB00527CinchocaineCalmodulintarget
DB00527CinchocaineCholinesteraseenzyme
DB14539Hydrocortisone acetateAnnexin A1target
DB14539Hydrocortisone acetateGlucocorticoid receptortarget
DB14539Hydrocortisone acetateSex hormone-binding globulincarrier
DB14539Hydrocortisone acetateCytochrome P450 3A4enzyme
DB14539Hydrocortisone acetateCytochrome P450 3A5enzyme
DB14539Hydrocortisone acetateCytochrome P450 3A7enzyme
DB14539Hydrocortisone acetateMultidrug resistance protein 1transporter
DB14539Hydrocortisone acetateSolute carrier organic anion transporter family member 1A2transporter
DB14539Hydrocortisone acetateATP-binding cassette sub-family G member 2transporter
DB14539Hydrocortisone acetateCytochrome P450 11B1, mitochondrialenzyme
DB14539Hydrocortisone acetateCytochrome P450 11B2, mitochondrialenzyme
DB14539Hydrocortisone acetateCytochrome P450 2C8enzyme
DB14539Hydrocortisone acetateCorticosteroid-binding globulincarrier
DB14539Hydrocortisone acetateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14539Hydrocortisone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14539Hydrocortisone acetateSolute carrier family 22 member 8transporter
DB00388PhenylephrineAlpha-1A adrenergic receptortarget
DB00388PhenylephrineAlpha-1B adrenergic receptortarget
DB00388PhenylephrineAmine oxidase [flavin-containing] Aenzyme
DB00388PhenylephrineAlpha-1D adrenergic receptortarget
DB00388PhenylephrineCytochrome P450 1A2enzyme
DB09345PramocaineVoltage gated sodium channeltarget
DrugDrug NamePhaseStatusCount
DB00297Bupivacaine0Active Not Recruiting1
DB01221Ketamine0Active Not Recruiting1
DB10659Leek1 / 2Unknown Status1
DB00741Hydrocortisone2Completed1
DB11686Iferanserin2Completed1
DB00281Lidocaine2Completed1
DB00281Lidocaine2 / 3Unknown Status1
DB00297Bupivacaine3Completed2
DB08995Diosmin3Unknown Status1
DB00916Metronidazole3Completed1
DB09153Sodium Chloride3Completed1
DB00297Bupivacaine4Completed1
DB00297Bupivacaine4Terminated1
DB00581Lactulose4Terminated1
DB00281Lidocaine4Completed1
DB00916Metronidazole4Not Yet Recruiting1
DB00750Prilocaine4Completed1
DB00316AcetaminophenNot AvailableCompleted1
DB00297BupivacaineNot AvailableCompleted1
DB01234DexamethasoneNot AvailableCompleted1
DB08995DiosminNot AvailableNot Yet Recruiting1
DB00996GabapentinNot AvailableCompleted1
DB01221KetamineNot AvailableCompleted1
DB09089TrimebutineNot AvailableSuspended1