Name
Laxatives
Accession Number
DBCAT001927  (DBCAT001403, DBCAT003703)
Description

Agents that produce a soft formed stool, stimulate intestinal motility, or otherwise promote emptying of the bowel. Typically used to relieve CONSTIPATION or to prepare the bowel for surgical procedures.

Drugs
DrugDrug Description
SorbitolA product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener.
DantronWithdrawn from the Canadian, US, and UK markets in 1998 due to genotoxicity.
OxyphenisatinA laxative that undergoes enterohepatic circulation. It may cause jaundice.
BisacodylA stimulant laxative used for the temporary relief of occasional constipation and cleansing of the colon as a preparation for colonoscopy in adults.
Picosulfuric acidA stimulant laxative used for cleansing of the colon as a preparation for colonoscopy in adults.
Polyethylene glycolA laxative used to treat constipation and used for bowel preparation before colonoscopies and other procedures.
PolycarbophilPolycarbophil is used to treat constipation and to help maintain regular bowel movements.
Sodium sulfateAn agent used for bowel cleansing prior to colonoscopy or barium enema X-ray examination.
CarboxymethylcelluloseA compound used as an ophthalmic lubricant.
Plantago seedAn ingredient used in a variety of natural health products.
Castor oilAn ingredient used in a variety of natural health products.
SennosidesA laxative used to treat constipation.
LactitolAn orally administered osmotic laxative used to treat chronic idiopathic constipation.
LactuloseA disaccharide derivative of lactose used to treat constipation and portal systemic encephalopathy.
GlycerinIt is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
Mineral oilMineral oil is not considered an active pharmacological ingredient in pharmaceutical preparations and so has no official indication. It is typically present in topical formulations as an emollient and occlusive...
DocusateA medication used to treat constipation associated with dry, hard stools, or opioid induced constipation.
MethylcelluloseA compound used as a bulk forming laxative and is not an approved medication.
Magnesium citrateA laxative used in bowel preparation for colonoscopy or as a magnesium supplement.
Magnesium hydroxideAn inorganic compound used as a laxative and antacid.
Magnesium oxideA compound commonly used as a laxative for the symptomatic relief of acid indigestion and upset stomach, and in health supplements for cardiovascular and neuromuscular health.
Magnesium sulfateA drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany.
Magnesium carbonateAn antacid used for symptomatic relief of heartburn, indigestion, and upset stomach.
PentaerithritylNot Annotated
Sodium tartrateIt acts as an emulsifier and pH control agent in food products , . In the laboratory, it is used while performing the Karl Fischer equation, which is used to...
MannitolA sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, and to measure glomerular filtration rate.
Sodium phosphate, monobasicA source of phosphorus used prevent or correct hypophosphatemia in patients with restricted or no oral intake.
Magnesium peroxideNot Annotated
PhenolphthaleinUsed for over a century as a laxative.
BisoxatinFor use in the treatment of constipation in the absence of bowel obstruction and for surgical preparation of the colon .
LubiprostoneA prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use.
LinaclotideA guanylate cyclase-C agonist used to treat constipation associated with irritable bowel syndrome or that is idiopathic in nature.
PrucaloprideA P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST).
TegaserodA serotonin-4 (5-HT4) receptor agonist indicated for the treatment of constipation predominant irritable bowel syndrome (IBS-C) specifically in women under the age of 65. There is currently no safety or efficacy data for use of tegaserol in men.
PlecanatideA laxative used to treat chronic idiopathic constipation and IBS with constipation.
DeacetylbisacodylNot Annotated
Magnesium cationMagnesium hydroxide is used primarily in "Milk of Magnesia", a white aqueous, mildly alkaline suspension of magnesium hydroxide formulated at about 8%w/v. Milk of magnesia is primarily used to alleviate...
ZincAn essential element commonly used for the treatment of patients with documented zinc deficiency.
Sodium cationNot Annotated
Sulfate ionNot Annotated
Plantago ovata seedNot Annotated
Phenylacetic acidAn agent used as an adjunct to treat acute hyperammonemia and associated encephalopathy in adult and pediatric patients with deficiencies in enzymes of the urea cycle.
Magnesium trisilicateAn antacid used for the symptomatic treatment of peptic ulcers.
Magnesium acetate tetrahydrateAn ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.
Monopotassium phosphateAn ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.
Dipotassium phosphateAn ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.
Sodium fluorophosphateA fluoride anticaries agent used to prevent and treat dental cavities.
Magnesium glycinateMagnesium glycinate is a magnesium salt of glycine that is available as dietary supplements as a source of magnesium. It is used in the treatment of magnesium deficiency.
Gluconic AcidAn electrolyte supplement used in total parenteral nutrition.
Sodium aurotiosulfateNot Annotated
Magnesium acetateNot Available
Sodium ascorbateNot Available
Potassium sulfateAn osmotic laxative used to cleanse the colon before a colonoscopy.
Sodium phosphate, dibasicAn osmotic laxative used to cleanse the colon before a colonoscopy.
Sodium phosphate, monobasic, unspecified formAn osmotic laxative used to cleanse the colon before a colonoscopy.
Sodium phosphate, dibasic, unspecified formAn osmotic laxative used to cleanse the colon before a colonoscopy.
MagnesiumA medication used for many purposes including constipation, indigestion, magnesium deficiency, and pre-eclampsia.
Oxyphenisatin acetateNot Annotated
Calcium polycarbophilA bulk forming laxative used to treat constipation.
EmodinEmodin has been investigated for the treatment of Polycystic Kidney.
Konjac mannanKonjac mannan is under investigation in clinical trial NCT01709955 (The Effects of Glucomannan on Weight Loss).
Potassium lactateNot Annotated
AlloinNot Annotated
Frangula purshiana barkNot Annotated
Dehydrocholic acidNo approved therapeutic indications.
Karaya gumAn extract from Karaya gum used in allergy testing.
Drugs & Drug Targets
DrugTargetType
SorbitolXylose isomerasetarget
SorbitolXylose isomerasetarget
SorbitolXylose isomerasetarget
SorbitolMalate synthase Gtarget
DantronSerum albumincarrier
Picosulfuric acidArylsulfate sulfotransferaseenzyme
Polyethylene glycolP-glycoprotein 1transporter
Sodium sulfateCarbonic anhydrase 2target
Sodium sulfateCarbonic anhydrase 1target
CarboxymethylcelluloseSolute carrier family 2, facilitated glucose transporter member 1target
Castor oilProstaglandin E2 receptor EP3 subtypetarget
Castor oilProstaglandin E2 receptor EP4 subtypetarget
SennosidesReverse transcriptase/RNaseHtarget
SennosidesAquaporin-3target
LactuloseEvolved beta-galactosidase subunit alphatarget
GlycerinHematopoietic prostaglandin D synthasetarget
GlycerinEndoglucanase Gtarget
GlycerinGlutathione S-transferase Ptarget
GlycerinGroup IIE secretory phospholipase A2target
GlycerinInositol-3-phosphate synthase 1target
GlycerinC4-dicarboxylate transport transcriptional regulatory protein DctDtarget
GlycerinAlcohol dehydrogenase 1Btarget
GlycerinInositol 1,4,5-trisphosphate receptor type 1target
GlycerinGlycodelintarget
GlycerinAlpha-N-acetylgalactosaminidasetarget
GlycerinCytochrome c4target
GlycerinBacterioferritintarget
GlycerinTGF-beta receptor type-2target
GlycerinArgininosuccinate synthasetarget
GlycerinEnolasetarget
GlycerinADP-ribosylation factor 1target
GlycerinMultidrug resistance protein MexAtarget
GlycerinBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1target
GlycerinHistidinol dehydrogenasetarget
GlycerinDNA mismatch repair protein MutLtarget
GlycerinGlycerol uptake facilitator proteintarget
GlycerinRibonucleoside-diphosphate reductase 1 subunit betatarget
GlycerinA/G-specific adenine glycosylasetarget
GlycerintRNA (cytosine(38)-C(5))-methyltransferasetarget
GlycerinCytochrome P450 2E1enzyme
GlycerinRetinal dehydrogenase 1enzyme
GlycerinPeroxisome proliferator-activated receptor deltatarget
Magnesium sulfateVoltage-dependent calcium channel gamma-1 subunittarget
Magnesium sulfateVoltage-dependent calcium channel subunit alpha-2/delta-1target
Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-1target
Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-2target
Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Starget
Magnesium carbonateTransient receptor potential cation channel subfamily M member 6transporter
Magnesium carbonateSolute carrier family 41 member 3transporter
Magnesium carbonateMetal transporter CNNM2transporter
Magnesium carbonateTransient receptor potential cation channel subfamily M member 7transporter
Magnesium carbonateGlutamate (NMDA) receptortarget
MannitolMannitol dehydrogenaseenzyme
Sodium phosphate, monobasicSodium-dependent phosphate transporter 1transporter
Sodium phosphate, monobasicSodium-dependent phosphate transporter 2transporter
Sodium phosphate, monobasicSodium-dependent phosphate transport protein 2Atransporter
Sodium phosphate, monobasicSodium-dependent phosphate transport protein 2Btransporter
Sodium phosphate, monobasicSodium-dependent phosphate transport protein 2Ctransporter
PhenolphthaleinUDP-glucuronosyltransferase 1-9target
PhenolphthaleinNuclear receptor subfamily 1 group I member 2target
PhenolphthaleinNuclear receptor subfamily 1 group I member 3target
PhenolphthaleinEstrogen receptor alphatarget
PhenolphthaleinSex hormone-binding globulintarget
LubiprostoneChloride channel protein 2target
LubiprostoneCarbonyl reductase [NADPH] 1enzyme
LinaclotideHeat-stable enterotoxin receptortarget
Prucalopride5-hydroxytryptamine receptor 4target
PrucaloprideCytochrome P450 3A4enzyme
PrucaloprideSerum albumincarrier
PrucaloprideP-glycoprotein 1transporter
Tegaserod5-hydroxytryptamine receptor 4target
Tegaserod5-hydroxytryptamine receptor 2Btarget
Tegaserod5-hydroxytryptamine receptor 2Ctarget
Tegaserod5-hydroxytryptamine receptor 2Atarget
TegaserodSodium-dependent serotonin transportertransporter
TegaserodCytochrome P450 1A2enzyme
TegaserodCytochrome P450 2C8enzyme
TegaserodCytochrome P450 2D6enzyme
TegaserodCytochrome P450 2E1enzyme
TegaserodATP-binding cassette sub-family G member 2transporter
TegaserodP-glycoprotein 1transporter
PlecanatideGuanylate cyclase soluble subunit alpha-2target
Magnesium cationSodium/potassium-transporting ATPase subunit alpha-1target
ZincB1 bradykinin receptortarget
ZincMethylated-DNA--protein-cysteine methyltransferasetarget
ZincFructose-bisphosphate aldolase Atarget
ZincElongation factor 1-alpha 1target
ZincAlpha-enolasetarget
ZincGlyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget
ZincNucleoside diphosphate kinase Atarget
ZincProtein disulfide-isomerasetarget
ZincProtein disulfide-isomerase A3target
ZincPeroxiredoxin-1target
ZincPhosphoserine phosphatasetarget
ZincTriosephosphate isomerasetarget
ZincElongation factor Tu, mitochondrialtarget
ZincEstrogen receptor alphatarget
ZincInterleukin-3target
ZincMetallothionein-2target
ZincCopper chaperone for superoxide dismutasetarget
ZincHistone deacetylase 1target
ZincHistone deacetylase 4target
ZincDNA-3-methyladenine glycosylasetarget
ZincSemenogelin-1target
ZincSuperoxide dismutase [Cu-Zn]target
ZincHistone deacetylase 8target
ZincApoptosis regulatory protein Sivatarget
ZincGlycine receptor subunit alpha-1target
ZincE3 ubiquitin-protein ligase Mdm2target
ZincInsulintarget
ZincUtrophintarget
ZincAspartoacylasetarget
ZincProtein S100-A8target
ZincProtein S100-A9target
ZincMatrix metalloproteinase-9target
ZincTumor protein p73target
ZincProtein S100-A2target
ZincCellular tumor antigen p53target
ZincMetallothionein-3target
ZincProgrammed cell death protein 6target
ZincDAN domain family member 5target
ZincMetallothionein-1Atarget
ZincAlpha-1B-glycoproteintarget
ZincAlpha-2-macroglobulintarget
ZincAngiotensinogentarget
ZincAlpha-2-HS-glycoproteintarget
ZincSerum amyloid P-componenttarget
ZincApolipoprotein A-Itarget
ZincApolipoprotein A-IItarget
ZincApolipoprotein A-IVtarget
ZincApolipoprotein B receptortarget
ZincApolipoprotein Etarget
ZincApolipoprotein L1target
ZincComplement C1q subcomponent subunit Btarget
ZincComplement C1q subcomponent subunit Ctarget
ZincComplement C1r subcomponenttarget
ZincComplement C1s subcomponenttarget
ZincComplement C3target
ZincComplement C4-Btarget
ZincC4b-binding protein alpha chaintarget
ZincC4b-binding protein beta chaintarget
ZincComplement C5target
ZincLys-63-specific deubiquitinase BRCC36target
ZincComplement component C8 alpha chaintarget
ZincComplement component C8 beta chaintarget
ZincComplement component C8 gamma chaintarget
ZincComplement factor Btarget
ZincComplement factor Htarget
ZincComplement factor Itarget
ZincClusterintarget
ZincCeruloplasmintarget
ZincCarboxypeptidase N catalytic chaintarget
ZincCarboxypeptidase N subunit 2target
ZincDermcidintarget
ZincDesmoplakintarget
ZincCoagulation factor XIItarget
ZincCoagulation factor XIII B chaintarget
ZincProthrombintarget
ZincFicolin-3target
ZincFibrinogen alpha chaintarget
ZincFibronectintarget
ZincGelsolintarget
ZincHemoglobin subunit alphatarget
ZincHemoglobin subunit betatarget
ZincHaptoglobin-related proteintarget
ZincHornerintarget
ZincInsulin-like growth factor-binding protein complex acid labile subunittarget
ZincIg alpha-1 chain C regiontarget
ZincIg mu chain C regiontarget
ZincImmunoglobulin kappa variable 1-17target
ZincIg kappa chain V-III region GOLtarget
ZincImmunoglobulin lambda variable 3-21target
ZincInter-alpha-trypsin inhibitor heavy chain H1target
ZincInter-alpha-trypsin inhibitor heavy chain H2target
ZincInter-alpha-trypsin inhibitor heavy chain H3target
ZincInter-alpha-trypsin inhibitor heavy chain H4target
ZincImmunoglobulin J chaintarget
ZincJunction plakoglobintarget
ZincPlasma kallikreintarget
ZincKininogen-1target
ZincKeratin, type II cytoskeletal 1target
ZincKeratin, type I cytoskeletal 10target
ZincKeratin, type I cytoskeletal 14target
ZincKeratin, type I cytoskeletal 16target
ZincKeratin, type II cytoskeletal 2 epidermaltarget
ZincKeratin, type II cytoskeletal 5target
ZincKeratin, type II cytoskeletal 6Atarget
ZincKeratin, type I cytoskeletal 9target
ZincAlpha-1-acid glycoprotein 2target
ZincN-acetylmuramoyl-L-alanine amidasetarget
ZincSerum paraoxonase/arylesterase 1target
ZincPregnancy zone proteintarget
ZincProtein S100-A7target
ZincSelenoprotein Ptarget
ZincAlpha-1-antitrypsintarget
ZincAlpha-1-antichymotrypsintarget
ZincKallistatintarget
ZincCorticosteroid-binding globulintarget
ZincHeparin cofactor 2target
ZincSex hormone-binding globulintarget
ZincSerotransferrintarget
ZincTransthyretintarget
ZincVitronectintarget
ZincAmyloid-like protein 1target
ZincAmyloid-like protein 2target
ZincAmyloid beta A4 proteintarget
ZincPoly [ADP-ribose] polymerase 1target
ZincCarbonic anhydrase 1enzyme
Phenylacetic acidLiver carboxylesterase 1enzyme
Magnesium acetate tetrahydrateGlutamate (NMDA) receptortarget
Monopotassium phosphateIntestinal-type alkaline phosphataseenzyme
Magnesium acetateSodium/potassium-transporting ATPase subunit alpha-1target
Potassium sulfateSodium/potassium-transporting ATPase subunit alpha-1target
Sodium phosphate, dibasicSodium-dependent phosphate transporter 1transporter
Sodium phosphate, dibasicSodium-dependent phosphate transporter 2transporter
Sodium phosphate, dibasicSodium-dependent phosphate transport protein 2Atransporter
Sodium phosphate, dibasicSodium-dependent phosphate transport protein 2Btransporter
Sodium phosphate, dibasicSodium-dependent phosphate transport protein 2Ctransporter
Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transporter 1transporter
Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transporter 2transporter
Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transport protein 2Atransporter
Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transport protein 2Btransporter
Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transport protein 2Ctransporter
MagnesiumSerum albumincarrier
MagnesiumClaudin-16transporter
MagnesiumTransient receptor potential cation channel subfamily M member 6transporter
MagnesiumTransient receptor potential cation channel subfamily M member 7transporter
MagnesiumSolute carrier family 41 member 1transporter
MagnesiumSolute carrier family 41 member 3transporter
MagnesiumMagnesium transporter MRS2 homolog, mitochondrialtransporter
EmodinCasein kinase II subunit alphatarget
EmodinPutative ketoacyl reductasetarget
Emodin3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZtarget
EmodinAryl hydrocarbon receptortarget