|DB00032||Menotropins||For the treatment of female infertility|
|DB00094||Urofollitropin||For treatment of female infertility|
|DB00098||Antithymocyte immunoglobulin (rabbit)||For prevention of renal transplant rejection|
|DB00908||Quinidine||For the treatment of ventricular pre-excitation and cardiac dysrhythmias|
|DB00965||Ethiodized oil||For use as a radio-opaque medium for hysterosalpingography and lymphography, and as an antineoplastic agent when part of the iodine is 131-I. It is also used in follow-up imaging for chemoembolization.|
|DB02955||Ricinoleic Acid||Not Available|
|DB04660||Choline alfoscerate||Not Available|
|DB04914||G17DT||Intended for the treatment of various forms of cancer.|
|DB05051||BZL101||Investigated for use/treatment in breast cancer.|
|DB05322||INGN 201||Investigated for use/treatment in bladder cancer, brain cancer, breast cancer, esophageal cancer, head and neck cancer, lung cancer, oral cavity cancer, ovarian cancer, and prostate cancer.|
|DB05325||INGN 225||Investigated for use/treatment in breast cancer, head and neck cancer, and lung cancer.|
|DB05374||Rindopepimut||Investigated for use/treatment in brain cancer.|
|DB05440||SRP 299||Investigated for use/treatment in asthma, atopic dermatitis, and pediatric atopic dermatitis indications.|
|DB05445||TA-NIC||Investigated for use/treatment in tobacco dependence.|
|DB05767||Andrographolide||Investigated for use/treatment in ulcerative colitis.|
|DB05771||LLL-3348||Investigated for use/treatment in psoriasis and psoriatic disorders.|
|DB05942||GI-5005||Investigated for use/treatment in hepatitis (viral, C).|
|DB06584||TG4010||Investigated for use/treatment in breast cancer, renal cell carcinoma, prostate cancer, and lung cancer.|
|DB09094||Podophyllin||25% podophyllin (in benzoin tincture) is indicated for the removal of soft genital (venereal) warts (condylomata acuminata).|
|DB09312||Antilymphocyte immunoglobulin (horse)||For prevention of renal transplant rejection and for the treatment of aplastic anemia.|
|DB09422||Soybean oil||Indicated for parenteral nutrition as a source of calories and essential fatty acids when oral or enteral nutrition is not possible, insufficient, or contraindicated. |
|DB09446||Safflower oil||No approved therapeutic indications.|
|DB09543||Methyl salicylate||Ointments or liniments containing methyl salicylate are applied topically as counter irritant for relief of acute pain associated with lumbago,sciatica and rheumatic conditions. Local analgesics for human and veterinary medicine.|
|DB09567||Olive oil||For use in adults as a source of calories and fatty acids in total parenteral nutrition [FDA Label]. Sometimes used as an additive in cosmetic products.|
|DB10283||Rabies virus inactivated antigen, A||Not Available|
|DB10318||Varicella Zoster Vaccine (Live/Attenuated)||Zostavax vaccine is indicated for the prevention of herpes zoster (shingles) in immunocompetent adults aged 50 years and older.
Varivax vaccine is indicated for active immunization for the prevention of varicella in individuals 12 months of age and older.|
|DB10535||Karaya gum||Not Available|
|DB10583||Clostridium tetani toxoid antigen (formaldehyde inactivated)||Not Available|
|DB10584||Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)||Not Available|
|DB11097||Plantago seed||Indications include the treatment of patients needing a high fibre regime, perhaps for: (a) the relief of constipation, including constipation in pregnancy and the maintenance of regularity; (b) the management of bowel function in patients with colostomy, ileostomy, hemorrhoids, anal fissure, chronic diarrhea with diverticular disease, irritable bowel syndrome, and ulcerative colitis [L1865].|
|DB11113||Castor oil||Indicated for over-the-counter use as a laxative for oral use and as a soothing agent for topical use on skin and hair. |
|DB11120||Turpentine||Turpentine has been used experimentally in a bath for the treatment of disseminated sclerosis and sexual dysfunction. It also has been studied for its antibacterial activity and inhibition of osteoclast activity. Turpentine is utilized in experimental models of inflammation to induce a systemic inflammatory immune response in animals.|
|DB11130||Opium||Opium and its derivatives are the most commonly used medications for the treatment of acute and chronic pain. Opium and its alkaloid-derivatives can also be used as tranquilizers, antitussives and in the treatment of diarrhea.[T138] The direct use of opium is not common nowadays but the use of some of its derivatives such as morphine and codeine, as well as the use of a tincture of opium for severe diarrhea can be seen in medical practice.[T139]
Illegal use of opium has been registered to be for both recreational and medicinal purposes.[A32182]|
|DB11131||Capsicum oleoresin||Indicated for the temporary relief of minor aches and pains of muscles and joints associated with simple backache, arthritis, strains and sprains. |
|DB11158||Pectin||Pectin is used in food as a gelling agent and stabilizer. As a medical drug, it has obtained a great interest in its potential use as a source of dietary fiber, lipid, cholesterol, serum glucose and insulin level lowering effect, gastric emptying delay.[A32327] Some recent studies have researched the possibility of using pectin for the formation of nanoparticles as a delivery vehicle of drugs.[A32331]|
|DB11172||Sesame oil||Not Available|
|DB11198||Peppermint oil||Indicated for the over-the-counter use for:
-the symptomatic relief of minor spasms of the gastrointestinal tract, flatulence and abdominal pain, especially in patients with irritable bowel syndrome.
-the temporary relief of itching associated with insect bites, eczema, minor burn, sunburn, minor skin irritations, minor cuts, scrapes, atopic dermatitis and other skin disorders.
-the temporary symptomatic relief of mild joint and muscle pain as a local topical analgesic.
-the temporary relief of tension-type headache.|
|DB11218||Tea tree oil||Indicated for topical use to help protect against infection in minor cuts, scrapes, and burns. No FDA-approved therapeutic indications.|
|DB11222||Benzoin resin||Indicated for mild antisepsis of skin, cuts, and abrasions. |
|DB11223||Tolu balsam||Not Available|
|DB11238||Borage oil||Not Available|
|DB11293||Rice bran oil||Not Available|
|DB11338||Clove oil||Clove oil is primarily indicated in conditions like colic, flatulence, and toothache [L2849].|
|DB11357||Linseed oil||Not Available|
|DB11358||Evening primrose oil||Evening primrose oil is used as part of over-the-counter dietary supplements.[L1113]
It is also used for the treatment of systemic inflammatory diseases and for women's health conditions such as cyclical mastalgia. These indications do not have sufficient evidence of their effectiveness. It was used for the treatment of atopic dermatitis in the United Kingdom but it is currently withdrawn due to lack of evidence of effectiveness.[A33131]|
|DB11365||Sennosides||For the over the counter treatment of constipation[FDA Label][L771].|
|DB11482||Balsam of Peru||Balsam of Peru is found in diverse cosmetics and perfumes as well as a flavoring agent in cough syrups, lozenges, chewing gum, and candies.[F117]
As a medical agent, balsam of Peru is used in the local treatment of burns and wounds as an antiseptic.[A27160] It is also used as an expectorant, heart stimulant to increase blood pressure and as a parasiticide.[T221]|
|DB11621||Human Varicella-Zoster Immune Globulin||Indicated for preventing and reducing the severity of chicken pox (varicella zoster virus) infections in high risk individuals within 4 days of exposure to varicella zoster virus.|
|DB12768||BCG vaccine||Not Available|
|DB13153||Levomenol||Levomenol has been known to elicit a number of potentially beneficial pharmacological effects, including anti-irritant, anti-inflammatory, and anti-microbial actions. Bisabolol is also demonstrated to enhance the percutaneous absorption of certain molecules|
|DB13293||Ipecac||Ipecac is indicated as an emetic agent for the induction of vomiting in poisoning victims who ingested systemic poison in order to prevent absorption of the chemicals through the gastrointestinal tract. In low doses, ipecac was also used as an expectorant.[L2753]
Reports have suggested that ipecac was vastly used in patients with eating disorders to produce vomiting.[T49]|
|DB13446||Guar gum||Not Available|
|DB13964||Peanut oil||Peanut oil is widely used in food and it is even the component for the adulteration of olive oil.[T41] It is used in over-the-counter ear drops to help lubricate the ear wax.[F124] It was also used as an ingredient in cleansing soaps, in emollient cream preparations or in laxatives.[L2892, F125]
Peanut oil is also used usually to solubilize drugs with poor water solubility as part of the oral formulation.[T224]
When orally administered, peanut oil has as well been researched and used to prevent heart diseases and lower cholesterol levels as well as to aid in weight loss and decrease appetite.[L2897]|
|DB14011||Nabiximols||In Canada, Sativex has received a Notice of Compliance (NOC) for use as an as adjunctive treatment for symptomatic relief of spasticity in patients with multiple sclerosis (MS) who have not responded adequately to other therapy and who demonstrate meaningful improvement during an initial trial of therapy.
Sativex has also received a Notice of Compliance with Conditions (NOC/c) for use as an adjunctive treatment for the symptomatic relief of neuropathic pain in adult patients with multiple sclerosis (MS) and as adjunctive analgesic treatment in adult patients with advanced cancer who experience moderate to severe pain during the highest tolerated dose of strong opioid therapy for persistent background pain.
Marketing authorisations with conditions reflect the promising nature of the clinical evidence and the need for confirmatory studies to verify the clinical benefit. Patients should be advised of the conditional nature of the authorizations with conditions.|
|DB14022||Typhoid vaccine||Not Available|
|DB14248||Bos taurus gallstone||Not Available|
|DB14304||Panax notoginseng root||Not Available|
|DB14307||Green tea leaf||Not Available|
|DB14309||Meadowfoam seed oil||Not Available|
|DB14310||Argan oil||Not Available|
|DB14316||Tangerine peel||Not Available|
|DB14322||Coconut oil||Not Available|
|DB14329||Sunflower oil||Not Available|
|DB14333||Nelumbo nucifera flower||Not Available|
|DB14335||Bergamot oil||Not Available|
|DB14336||Angelica sinensis root||Not Available|
|DB14345||Forsythia suspensa fruit||Not Available|
|DB14360||Saw palmetto||Not Available|
|DB14364||Scutellaria baicalensis root||Not Available|
|DB14377||Palm oil||Not Available|
|DB14565||Sophora flavescens root||Not Available|
|DB14566||Lavender oil||Not Available|
|DB14585||Plantago ovata seed||Not Available|
|DB10394||Phleum pratense pollen||Not Available|
|DB10805||Yellow Fever Vaccine||Yellow Fever Vaccine is indicated for active immunization for the prevention of yellow fever in persons 9 months of age and older in the following categories:
1. Persons Living in or Traveling to Endemic Areas: While the actual risk for contracting yellow fever during travel is probably low, variability of itineraries, behaviors and seasonal incidence of disease make it difficult to predict the actual risk for a given individual living in or traveling to a known endemic or epidemic area. Greater risk is associated with living in or traveling to areas of South America and Africa where yellow fever infection is officially reported at the time of travel and with traveling outside the urban areas of countries that do not officially report the disease but that lie in a yellow fever endemic zone.
2. Persons Travelling Internationally Through Countries with Yellow Fever: Some countries require an individual to have a valid International Certificate of Vaccination or Prophylaxis (ICVP) if the individual has been in countries either known or thought to harbor yellow fever virus. The certificate becomes valid 10 days after vaccination with Yellow Fever Vaccine.
3. Laboratory Personnel: Laboratory personnel who handle virulent yellow fever virus or concentrated preparations of the yellow fever vaccine virus strains may be at risk of exposure by direct or indirect contact or by aerosols.|
|DB10989||Hepatitis A Vaccine||Hepatitis A vaccine is indicated for active immunization against disease caused by hepatitis A virus (HAV). It is approved for use in persons 12 months of age and older. Primary immunization should be administered at least 2 weeks prior to expected exposure to HAV.
HAVRIX® will not prevent hepatitis infection caused by other agents such as hepatitis B virus, hepatitis C virus, hepatitis E virus or other pathogens known to infect the liver.
In areas of low to intermediate prevalence of hepatitis A, immunization with HAVRIX® is particularly recommended in subjects who are, or will be, at increased risk of infection such as:
* Travelers: Persons traveling to areas where the prevalence of hepatitis A is high. These areas include Africa, Asia, the Mediterranean basin, the Middle East, Central and South America.
* Armed Forces: Armed Forces personnel who travel to higher endemicity areas or to areas where hygiene is poor have an increased risk of HAV infection. Active immunization is indicated for these individuals.
* Persons for whom Hepatitis A is an Occupational Hazard: These include employees in day-care centres, nursing, medical and paramedical personnel in hospitals and institutions, especially gastroenterology and pediatric units, sewage workers, and food handlers, among others.
* Persons for whom there is an Increased Risk of Transmission of Hepatitis A: e.g. homosexuals, persons with multiple sexual partners, abusers of injectable drugs, hemophiliac patients.
* Contacts of Infected Persons: Since virus shedding of infected persons may occur for a prolonged period, active immunization of close contacts is recommended.
* Specific Population Groups known to have Higher Incidence of Hepatitis A: e.g. North American Indians, Inuits, recognized community-wide HAV epidemics.
* Subjects with chronic liver disease or who are at risk of developing chronic liver disease e.g. Hepatitis B (HB) and Hepatitis C (HC) chronic carriers and alcohol abusers.|
|DB11627||Hepatitis B Vaccine (Recombinant)||Active immunization against hepatitis B virus infection.
The vaccine will not protect against infection caused by hepatitis A and non-A non-B hepatitis viruses. As hepatitis D (caused by the delta agent) does not occur in the absence of hepatitis B infection or carrier state, it can be expected that hepatitis D will also be prevented by vaccination with hepatitis B virus vaccine.
The vaccine can be administered at any age from birth onwards. It may be used to start a primary course of vaccination or as a booster dose. It may also be used to complete a primary course of vaccination started with plasma-derived or yeast-derived vaccines or as a booster dose in subjects who have previously received a primary course of vaccination with plasma-derived or yeast-derived vaccines.
In areas of low prevalence of hepatitis B, vaccination is strongly recommended in subjects who are at increased risk of infection. These include the following groups:
* Health professionals: physicians and surgeons; oral surgeons and dentists; nurses, dental nurses, dental hygienists, podiatrists; IV teams and operating room personnel; paramedical personnel in close contact with patients; staff in hemodialysis, nephrology, hepatology, hematology and oncology units; laboratory personnel handling blood and other clinical specimens; blood bank and plasma fractionation workers; pathologists and morgue attendants; cleaning staff who handle waste in hospitals; emergency and first aid workers; ambulance staff; dental, medical and nursing students.
* Patients: patients receiving frequent blood transfusion or clotting factor concentrates, such as those in oncology units and those with thalassemia, sickle-cell anemia, cirrhosis, hemophilia, etc.; patients on hemodialysis; patients with type 2 diabetes.
* Personnel and residents of institutions: persons with frequent and/or close contacts with high-risk groups; prisoners and prison staff; residents and staff of institutions for the developmentally challenged (those who are in contact with aggressive biting residents being at highest risk).
* Persons at increased risk due to their sexual practices: males having sexual contact with other males; others with multiple sexual partners or with a recent history of sexually transmitted disease.
* Persons who use injectable drugs illicitly.
* Travellers to areas of high endemicity and their close contacts.
* Household contacts of any of the above groups and of patients with acute or chronic hepatitis B infection.
* Infants born of HBsAg-positive mothers.
* Chronic Liver Disease (CLD): subjects with chronic liver disease; subjects at risk of developing CLD (e.g. Hepatitis C virus carriers, persons who abuse alcohol).
* Others: police; fire fighters; armed forces personnel; morticians and embalmers; those who through their work or personal lifestyle may be exposed to the hepatitis B virus.
* In areas of both low and high prevalence, vaccination should be offered to all young children and neonates at risk, as well as to adult high risk groups.|
|DB01381||Ginkgo biloba||Appears to be effective in: alleviating age-related memory impairment in some elderly people with mild to moderate age-related memory or cognitive impairment; improving cognitive function in healthy young to middle-aged people; improving symptoms of Alzheimer's, vascular or mixed dementia; improving damage to the visual field in patients with normal tension glaucoma; decreasing the number of painful attacks in patients with Raynaud's syndrome; and may improve symptoms of vertigo and dizziness in some patients. |
|DB06400||Vitespen||Investigated for use/treatment in kidney cancer, melanoma, renal cell carcinoma, lymphoma (unspecified), colorectal cancer, and brain cancer.|
|DB15274||Pertussis vaccine||Not Available|
|DB15461||Yersinia pestis 195/p antigen (formaldehyde inactivated)||Not Available|