NAV

Zinc phenolsulfonate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Zinc phenolsulfonate is an ingredient in ophthalmic solutions indicated in the treatment of minor irritation and conjunctivitis.

Generic Name
Zinc phenolsulfonate
DrugBank Accession Number
DB15793
Background

Not Available

Type
Small Molecule
Groups
Approved, Experimental
Structure
Similar Structures
Weight
Average: 411.7
Monoisotopic: 409.910852
Chemical Formula
C12H10O8S2Zn
Synonyms
  • p-hydroxybenzenesulfonic acid zinc salt
  • Phenozin
  • Zinc p-phenolsulfonate
  • Zinc p-phenolsulphonate
  • Zinc paraphenolsulfonate
  • Zinc paraphenolsulphonate
  • Zinc phenolsulfonate
  • Zinc phenolsulphonate
  • Zinc sulfocarbolate
External IDs
  • Caswell No. 921A
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Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to treatConjunctivitisCombination Product in combination with: Naphazoline (DB06711), Sulfacetamide (DB00634), Lidocaine (DB00281)••• ••••••••••• • •••••
Used in combination to treatEye rednessCombination Product in combination with: Naphazoline (DB06711)••••••••••••
Used in combination to treatForeign body sensation in eyeCombination Product in combination with: Naphazoline (DB06711)••••••••••••
Used in combination to treatHeavy feeling of the eyelidCombination Product in combination with: Naphazoline (DB06711)••••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Diaret TabZinc phenolsulfonate (30 mg / tab) + Aluminum hydroxide (70 mg / tab) + Attapulgite (350 mg / tab) + Pectin (45 mg / tab)TabletOralProduits Francais Labs Inc.1981-12-311997-05-30Canada flag
Diarex TabZinc phenolsulfonate (30 mg / tab) + Aluminum hydroxide (70 mg / tab) + Attapulgite (350 mg / tab) + Pectin (45 mg / tab)TabletOralNutribon (1986) Inc.1995-12-311996-09-30Canada flag
Racord Two 7Zinc phenolsulfonate (.4 mg / 2.54 cm) + Racepinephrine hydrochloride (.225 mg / 2.54 cm)PackingDentalPascal International Corporation1992-12-311998-07-23Canada flag
Racord Two No 10Zinc phenolsulfonate (1.45 mg / 2.5 cm) + Racepinephrine hydrochloride (.3 mg / 2.5 cm)PackingDentalPascal International Corporation1996-08-141998-07-23Canada flag
Racord Two No 8Zinc phenolsulfonate (.4 mg / 2.5 cm) + Racepinephrine hydrochloride (.23 mg / 2.5 cm)PackingDentalPascal International Corporation1997-08-121998-07-23Canada flag

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
4O71YT5YB5
CAS number
127-82-2
InChI Key
ZNVKGUVDRSSWHV-UHFFFAOYSA-L
InChI
InChI=1S/2C6H6O4S.Zn/c2*7-5-1-3-6(4-2-5)11(8,9)10;/h2*1-4,7H,(H,8,9,10);/q;;+2/p-2
IUPAC Name
zinc(2+) bis(4-hydroxybenzene-1-sulfonate)
SMILES
[Zn++].OC1=CC=C(C=C1)S([O-])(=O)=O.OC1=CC=C(C=C1)S([O-])(=O)=O

References

General References
  1. AIFA approved drug products: Oftalmil (Naphazoline / Zinc phenolsulfonate) ophthalmic solution [Link]
ChemSpider
29122
RxNav
89831

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Solution / dropsOphthalmic
TabletOral
PackingDental
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.272 mg/mLALOGPS
logP1.35ALOGPS
logP0.85Chemaxon
logS-3.2ALOGPS
pKa (Strongest Acidic)-2.6Chemaxon
pKa (Strongest Basic)-6.1Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area77.43 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity37.54 m3·mol-1Chemaxon
Polarizability14.87 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at August 28, 2020 15:42 / Updated at May 14, 2021 01:08