Identification

Name
Lidocaine
Accession Number
DB00281  (APRD00479, DB05291)
Type
Small Molecule
Groups
Approved, Vet approved
Description

A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.

Structure
Thumb
Synonyms
  • 2-(Diethylamino)-2',6'-acetoxylidide
  • 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
  • alpha-diethylamino-2,6-dimethylacetanilide
  • Lignocaine
  • α-diethylamino-2,6-dimethylacetanilide
External IDs
ALGRX 3268 / ALGRX-3268 / LSM-3165 / NSC-40030
Product Ingredients
IngredientUNIICASInChI Key
Lidocaine hydrochlorideV13007Z41A6108-05-0YECIFGHRMFEPJK-UHFFFAOYSA-N
Lidocaine hydrochloride anhydrousEC2CNF7XFP73-78-9IYBQHJMYDGVZRY-UHFFFAOYSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
2% Lidocaine Hydrochloride Injection USPSolution20 mgIntravenousHospira, Inc.1987-12-31Not applicableCanada
AgonEazeKitTopicalAlvix Laboratories2016-01-12Not applicableUs
AktenGel35 mg/mLOphthalmicAkorn2008-10-08Not applicableUs
Amniocentesis Tray 1%Liquid1 %Infiltration; SubcutaneousAllegiance Healthcare Corporation1992-12-312000-07-31Canada
Antecubital Cent Venous Catheterization KitLiquid1 %EpiduralArrow International1991-12-311999-07-02Canada
Arthrogram Tray 1%Liquid1 %Intra-articularAllegiance Healthcare Corporation1992-12-312000-07-31Canada
AsteroGel40 mg/gTopicalAll Pharma, Llc2016-05-012018-01-06Us
AsteroGel40 mg/gTopicalGensco Laboratories, LLC2016-05-012018-01-06Us
Atelocollagen ImplantImplant.3 %IntradermalKoken Co. Ltd.1989-12-312005-08-25Canada
Basic Biopsy Tray 1%Liquid1 %Infiltration; SubcutaneousAllegiance Healthcare Corporation1992-12-312000-07-31Canada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AnestaconJelly20 mg/mLTopicalHi Tech Pharmacal Co., Inc.2001-11-05Not applicableUs
Anodyne IleKitFortus Pharma, Llc2017-10-16Not applicableUs
DermacinRx Lido V PakKitTopicalPure Tek Corporation2016-09-22Not applicableUs
DermacinRx PHN PakKitPure Tek Corporation2016-05-172018-01-23Us
DX1 OraGenomic Medicated DNA Collection ScreenKitIt3 Medical Llc2016-05-01Not applicableUs
DX2 OraGenomic Medicated DNA Collection ScreenKitIt3 Medical Llc2016-05-01Not applicableUs
DyNAmic KitKitOral; TopicalAlvix Laboratories2015-04-172018-03-12Us
GlydoJelly20 mg/mLTopicalSagent Pharmaceuticals2014-09-15Not applicableUs
Inflammation Reduction PackKitTmig, Inc.2015-08-18Not applicableUs
Laryng-O-JetSolution40 mg/mLTopicalAmphastar Pharmaceuticals, Inc.1980-03-062017-01-06Us
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Absorbine jr. LidocainePatch246 mg/1TopicalClarion Brands, Llc2017-01-01Not applicableUs
Acme Home/Office/Auto KitKitDukal Corporation2010-05-01Not applicableUs
ADVANCED NUMB Topical AnestheticCream50 mg/gTopicalUber Scientific, Llc2018-04-20Not applicableUs
After BurnGel25 mg/mLTopicalTender Corporation2011-04-12Not applicableUs
After Sun Burn Relief Lidocaine Continuous SpraySolution1 %TopicalPrime Enterprises, Inc.2010-04-08Not applicableCanada
After Sun GelGel1 %TopicalWatkins IncorporatedNot applicableNot applicableCanada
After Sun Soothing SprayLiquid; Spray0.5 %TopicalKinesys Pharmaceutical Inc1995-03-17Not applicableCanada
AfterBurnGel2.5 g/100gTopicalTender Corporation2011-04-122016-11-03Us
AfterBurnGel0.5 %TopicalTender Corporation1995-12-31Not applicableCanada
Aftersun Cooling CVSGel.5 g/100mLTopicalCVS Health2014-11-112018-02-27Us
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
0.4% Lidocaine Hydrochloride and 5% Dextrose Injection USPLidocaine hydrochloride (4 mg) + Dextrose, unspecified form (50 mg)SolutionIntravenousHospira, Inc.1983-12-31Not applicableCanada
10 Person ANSILidocaine + Acetaminophen + Acetylsalicylic acid + Bacitracin zinc + Benzalkonium chloride + Benzocaine + Ethanol + Ibuprofen + Neomycin sulfate + Polymyxin B Sulfate + WaterKitGenuine First Aid2010-04-24Not applicableUs
1st RELIEF TOPICALLidocaine (40 mg/mL) + Menthol (10 mg/mL)SprayTopical1st Class Pharmaceuticals2014-12-02Not applicableUs
2% Lidocaine and Epinephrine 1:100,000 Injection USPLidocaine hydrochloride (20 mg) + Epinephrine (0.01 mg)LiquidInfiltrationAlveda Pharmaceuticals Inc2008-12-01Not applicableCanada
25 Person ANSILidocaine + Acetaminophen + Acetylsalicylic acid + Bacitracin zinc + Benzalkonium chloride + Benzocaine + Ethanol + Ibuprofen + Isopropyl Alcohol + Neomycin sulfate + Polymyxin B Sulfate + WaterKitGenuine First Aid2010-04-25Not applicableUs
3-Step First Aid KitLidocaine hydrochloride + Benzalkonium chloride + Povidone-iodineKitTopicalSwabplus Inc.2003-03-01Not applicableUs
5% Xylocaine Mpf With Glucose 7.5% InjectionLidocaine hydrochloride (5 %) + Dextrose, unspecified form (7.5 %)LiquidSubarachnoidSmiths Medical Canada Ltd.Not applicableNot applicableCanada
50 Person ANSILidocaine + Acetaminophen + Acetylsalicylic acid + Bacitracin zinc + Benzalkonium chloride + Benzocaine + Ethanol + Ibuprofen + Isopropyl Alcohol + Neomycin sulfate + Polymyxin B Sulfate + WaterKitGenuine First Aid2010-06-02Not applicableUs
ACME FIRST AID Contains 404 PIECESLidocaine + Acetylsalicylic acid + Bacitracin zinc + Benzalkonium chloride + Benzocaine + Ethanol + Isopropyl Alcohol + Neomycin sulfate + Polymyxin B Sulfate + WaterKitAcme United Corporation2010-04-27Not applicableUs
ACME Small Cuts and BurnsLidocaine + Bacitracin zinc + Benzalkonium chloride + Neomycin sulfate + Polymyxin B SulfateKitAcme United Corporation2010-04-30Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
1st Medxpatch With Lidocaine 4%Lidocaine (4 1/1) + Capsaicin (.0375 1/1) + Menthol (5 1/1) + Methyl salicylate (20 1/1)PatchTopical1 St Medx Llc2018-03-15Not applicableUs
1st Medxpatch With Lidocaine 4%-rxLidocaine (4 1/1) + Capsaicin (.0375 1/1) + Menthol (5 1/1) + Methyl salicylate (20 1/1)PatchTopical1 St Medx Llc2018-03-15Not applicableUs
AccucaineLidocaine hydrochloride (10 mg/mL)Injection, solutionInfiltrationAsclemed Usa, Inc.1972-09-28Not applicableUs
AdazinLidocaine (2 g/100g) + Benzocaine (2 g/100g) + Capsaicin (.035 g/100g) + Methyl salicylate (1 g/100g)CreamTopicalSterling Knight Pharmaceuticals, Llc2014-12-03Not applicableUs
Advanced DNA Medicated CollectionLidocaine hydrochloride + GlycerinKitOral; TopicalAsclemed Usa, Inc1995-07-10Not applicableUs
Advanced DNA Medicated Collection Kit IILidocaine hydrochloride + GlycerinKitOral; TopicalAsclemed Usa, Inc.2014-02-04Not applicableUs
Advanced DNA Medicated Collection Kit IIILidocaine hydrochloride + GlycerinKitOral; TopicalAsclemed Usa, Inc.2014-02-04Not applicableUs
Ambator Lidocaine PatchLidocaine hydrochloride (1 g/10g)PatchTopical7 T Pharma Llc2017-12-152018-04-03Us
Ana-LexLidocaine hydrochloride (20 mg/g) + Hydrocortisone acetate (20 mg/g)CreamTopicalAvion Pharmaceuticals, Llc2008-02-28Not applicableUs
AnodyneRxLidocaine (2.5 g/1) + Capsaicin (.05 g/1) + Menthol (5 g/1)PatchTopicalGen Pak Solutions, Llc2015-04-012016-10-13Us
International/Other Brands
After Burn Double Strength Gel / After Burn Double Strength Spray / After Burn Gel / After Burn Spray / Alphacaine / Anestacon Jelly / DermaFlex / Dilocaine / Esracaine / L-Caine / Lidoject-1 / Lidoject-2 / LidoPain SP / Norwood Sunburn Spray / Xylocard
Categories
UNII
98PI200987
CAS number
137-58-6
Weight
Average: 234.3373
Monoisotopic: 234.173213336
Chemical Formula
C14H22N2O
InChI Key
NNJVILVZKWQKPM-UHFFFAOYSA-N
InChI
InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
IUPAC Name
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
SMILES
CCN(CC)CC(=O)NC1=C(C)C=CC=C1C

Pharmacology

Indication

For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.

Associated Conditions
Associated Therapies
Pharmacodynamics

Lidocaine is an anesthetic agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Lidocaine appears to be similar to that of procaine, procainamide and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected. In contrast to the latter 3 drugs, Lidocaine in therapeutic doses does not produce a significant decrease in arterial pressure or in cardiac contractile force. In larger doses, lidocaine may produce circulatory depression, but the magnitude of the change is less than that found with comparable doses of procainamide.

Mechanism of action

Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. Lidocaine alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation. With sufficient blockage the membrane of the postsynaptic neuron will not depolarize and will thus fail to transmit an action potential. This creates the anaesthetic effect by not merely preventing pain signals from propagating to the brain but by aborting their birth in the first place.

TargetActionsOrganism
ASodium channel protein type 10 subunit alpha
inhibitor
Human
ASodium channel protein type 9 subunit alpha
inhibitor
Human
ASodium channel protein type 5 subunit alpha
inhibitor
Human
UEpidermal growth factor receptor
antagonist
Human
USodium channel protein type 4 subunit alphaNot AvailableHuman
UAlpha-1-acid glycoprotein 1Not AvailableHuman
UAlpha-1-acid glycoprotein 2Not AvailableHuman
Absorption

Information derived from diverse formulations, concentrations and usages reveals that lidocaine is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon various factors such as the site of administration and the presence or absence of a vasoconstrictor agent.

Volume of distribution
  • 0.7 to 2.7 L/kg [healthy volunteers]
Protein binding

60-80%

Metabolism

Primarily hepatic.

Route of elimination

Lidocaine and its metabolites are excreted by the kidneys.

Half life

109 minutes

Clearance
  • 0.64 +/- 0.18 L/min
Toxicity

The oral LD 50 of lidocaine HCl in non-fasted female rats is 459 (346-773) mg/kg (as the salt) and 214 (159-324) mg/kg (as the salt) in fasted female rats. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Lidocaine (Local Anaesthetic) Action PathwayDrug action
Lidocaine (Antiarrhythmic) Action PathwayDrug action
Lidocaine (Local Anaesthetic) Metabolism PathwayDrug metabolism
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(R)-warfarinThe metabolism of (R)-warfarin can be decreased when combined with Lidocaine.Experimental
3-isobutyl-1-methyl-7H-xanthineThe metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Lidocaine.Experimental
6-O-benzylguanineThe metabolism of 6-O-benzylguanine can be decreased when combined with Lidocaine.Investigational
8-chlorotheophyllineThe metabolism of 8-chlorotheophylline can be decreased when combined with Lidocaine.Approved
AbemaciclibThe serum concentration of Abemaciclib can be increased when it is combined with Lidocaine.Approved, Investigational
AbirateroneThe serum concentration of Lidocaine can be increased when it is combined with Abiraterone.Approved
AcebutololThe serum concentration of Lidocaine can be increased when it is combined with Acebutolol.Approved, Investigational
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Lidocaine.Approved, Investigational
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Lidocaine.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Lidocaine.Approved, Vet Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Lidocaine.Approved
AgomelatineThe serum concentration of Agomelatine can be increased when it is combined with Lidocaine.Approved, Investigational
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Lidocaine.Approved, Vet Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Lidocaine.Experimental, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Lidocaine.Approved, Investigational
AlosetronThe metabolism of Alosetron can be decreased when combined with Lidocaine.Approved, Withdrawn
AlprenololThe serum concentration of Lidocaine can be increased when it is combined with Alprenolol.Approved, Withdrawn
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Lidocaine.Approved, Investigational
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Lidocaine.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Lidocaine.Approved
AmiodaroneThe risk or severity of generalized seizure and bradycardia can be increased when Amiodarone is combined with Lidocaine.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Lidocaine.Approved
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Lidocaine.Approved, Investigational
AnagrelideThe metabolism of Anagrelide can be decreased when combined with Lidocaine.Approved
AnisodamineThe serum concentration of Lidocaine can be increased when it is combined with Anisodamine.Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Lidocaine.Approved, Investigational
ApalutamideThe serum concentration of Lidocaine can be decreased when it is combined with Apalutamide.Approved, Investigational
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Lidocaine.Approved
AprepitantThe serum concentration of Lidocaine can be increased when it is combined with Aprepitant.Approved, Investigational
ArotinololThe serum concentration of Lidocaine can be increased when it is combined with Arotinolol.Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Lidocaine.Approved, Investigational
Ascorbic acidThe serum concentration of Ascorbic acid can be increased when it is combined with Lidocaine.Approved, Nutraceutical
AsenapineThe metabolism of Asenapine can be decreased when combined with Lidocaine.Approved
AsunaprevirThe serum concentration of Asunaprevir can be increased when it is combined with Lidocaine.Approved, Investigational, Withdrawn
AtazanavirThe metabolism of Lidocaine can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Lidocaine can be increased when it is combined with Atenolol.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Lidocaine.Approved
AvatrombopagThe serum concentration of Avatrombopag can be increased when it is combined with Lidocaine.Approved, Investigational
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Lidocaine.Approved, Investigational
AzathioprineThe metabolism of Azathioprine can be decreased when combined with Lidocaine.Approved
BaricitinibThe serum concentration of Baricitinib can be increased when it is combined with Lidocaine.Approved, Investigational
BefunololThe serum concentration of Lidocaine can be increased when it is combined with Befunolol.Experimental
BelinostatThe serum concentration of Belinostat can be increased when it is combined with Lidocaine.Approved, Investigational
BenzydamineThe metabolism of Benzydamine can be decreased when combined with Lidocaine.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Lidocaine.Approved, Vet Approved
BetaxololThe serum concentration of Lidocaine can be increased when it is combined with Betaxolol.Approved, Investigational
BevantololThe serum concentration of Lidocaine can be increased when it is combined with Bevantolol.Approved
BisoprololThe serum concentration of Lidocaine can be increased when it is combined with Bisoprolol.Approved
BoceprevirThe metabolism of Lidocaine can be decreased when combined with Boceprevir.Approved, Withdrawn
BopindololThe serum concentration of Lidocaine can be increased when it is combined with Bopindolol.Approved
BortezomibThe metabolism of Lidocaine can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Lidocaine can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Lidocaine.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Lidocaine.Approved, Investigational
BromazepamThe metabolism of Bromazepam can be decreased when combined with Lidocaine.Approved, Illicit, Investigational
BromperidolThe serum concentration of Bromperidol can be increased when it is combined with Lidocaine.Approved, Investigational
BucindololThe serum concentration of Lidocaine can be increased when it is combined with Bucindolol.Investigational
BufuralolThe serum concentration of Lidocaine can be increased when it is combined with Bufuralol.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Lidocaine.Approved, Investigational
BupranololThe serum concentration of Lidocaine can be increased when it is combined with Bupranolol.Approved
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Lidocaine.Approved
CaffeineThe metabolism of Lidocaine can be decreased when combined with Caffeine.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Lidocaine.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Lidocaine.Approved
CarbamazepineThe metabolism of Lidocaine can be increased when combined with Carbamazepine.Approved, Investigational
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Lidocaine.Approved, Investigational
CarteololThe serum concentration of Lidocaine can be increased when it is combined with Carteolol.Approved
CarvedilolThe serum concentration of Lidocaine can be increased when it is combined with Carvedilol.Approved, Investigational
CeliprololThe serum concentration of Lidocaine can be increased when it is combined with Celiprolol.Approved, Investigational
CeritinibThe serum concentration of Lidocaine can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Lidocaine.Approved, Withdrawn
Cerliponase alfaThe serum concentration of Cerliponase alfa can be increased when it is combined with Lidocaine.Approved, Investigational
ChlorambucilThe serum concentration of Chlorambucil can be increased when it is combined with Lidocaine.Approved
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Lidocaine.Approved
CilostazolThe metabolism of Cilostazol can be decreased when combined with Lidocaine.Approved, Investigational
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Lidocaine.Approved, Investigational
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Lidocaine.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Lidocaine.Approved, Investigational
CiprofloxacinThe metabolism of Lidocaine can be decreased when combined with Ciprofloxacin.Approved, Investigational
CisaprideThe metabolism of Cisapride can be decreased when combined with Lidocaine.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Lidocaine.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Lidocaine.Approved
ClarithromycinThe metabolism of Lidocaine can be decreased when combined with Clarithromycin.Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Lidocaine.Approved, Illicit
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Lidocaine.Approved, Investigational, Vet Approved
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Lidocaine.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Lidocaine.Approved
CloranololThe serum concentration of Lidocaine can be increased when it is combined with Cloranolol.Experimental
ClotrimazoleThe metabolism of Lidocaine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Lidocaine.Approved
CobicistatThe metabolism of Lidocaine can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Lidocaine.Approved, Investigational
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Lidocaine.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Lidocaine.Approved, Investigational
Conjugated estrogensThe serum concentration of Conjugated estrogens can be increased when it is combined with Lidocaine.Approved
CopanlisibThe serum concentration of Copanlisib can be increased when it is combined with Lidocaine.Approved, Investigational
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Lidocaine.Approved
CurcuminThe metabolism of Lidocaine can be decreased when combined with Curcumin.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
Cyproterone acetateThe serum concentration of Lidocaine can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Lidocaine.Approved, Investigational
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Lidocaine.Approved
DabrafenibThe serum concentration of Lidocaine can be decreased when it is combined with Dabrafenib.Approved, Investigational
DacarbazineThe metabolism of Dacarbazine can be decreased when combined with Lidocaine.Approved, Investigational
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Lidocaine.Approved, Investigational
DanazolThe metabolism of Lidocaine can be decreased when combined with Danazol.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Lidocaine.Approved
DapsoneThe risk or severity of adverse effects can be increased when Dapsone is combined with Lidocaine.Approved, Investigational
DarunavirThe metabolism of Lidocaine can be decreased when combined with Darunavir.Approved
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Lidocaine.Approved
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Lidocaine.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Lidocaine.Approved, Investigational
DeferasiroxThe serum concentration of Lidocaine can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Lidocaine can be decreased when combined with Delavirdine.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Lidocaine.Approved, Investigational
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Lidocaine.Approved, Illicit, Investigational, Withdrawn
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Lidocaine.Approved, Illicit, Investigational, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Lidocaine.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Lidocaine.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Lidocaine.Approved, Investigational
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Lidocaine.Approved, Investigational
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Lidocaine.Approved
DihydralazineThe metabolism of Dihydralazine can be decreased when combined with Lidocaine.Approved, Investigational
DiltiazemThe metabolism of Lidocaine can be decreased when combined with Diltiazem.Approved, Investigational
DinoprostoneThe metabolism of Dinoprostone can be decreased when combined with Lidocaine.Approved
DisopyramideDisopyramide may increase the arrhythmogenic activities of Lidocaine.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Lidocaine.Approved, Investigational
DolutegravirThe serum concentration of Dolutegravir can be increased when it is combined with Lidocaine.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
DosulepinThe metabolism of Lidocaine can be decreased when combined with Dosulepin.Approved
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Lidocaine.Approved, Investigational
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Lidocaine.Approved, Investigational
DoxycyclineThe metabolism of Lidocaine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronedaroneThe metabolism of Lidocaine can be decreased when combined with Dronedarone.Approved
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Lidocaine.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Lidocaine.Approved
EfavirenzThe metabolism of Lidocaine can be decreased when combined with Efavirenz.Approved, Investigational
ElagolixThe serum concentration of Elagolix can be increased when it is combined with Lidocaine.Approved, Investigational
ElbasvirThe serum concentration of Elbasvir can be increased when it is combined with Lidocaine.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Lidocaine.Approved, Investigational
EltrombopagThe metabolism of Eltrombopag can be decreased when combined with Lidocaine.Approved
EnasidenibThe metabolism of Enasidenib can be decreased when combined with Lidocaine.Approved, Investigational
EnoxacinThe metabolism of Lidocaine can be decreased when combined with Enoxacin.Approved, Investigational
EnzalutamideThe serum concentration of Lidocaine can be decreased when it is combined with Enzalutamide.Approved
EpanololThe serum concentration of Lidocaine can be increased when it is combined with Epanolol.Experimental
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Lidocaine.Approved, Investigational
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Lidocaine.Approved, Investigational
ErtugliflozinThe serum concentration of Ertugliflozin can be increased when it is combined with Lidocaine.Approved, Investigational
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
EsatenololThe serum concentration of Lidocaine can be increased when it is combined with Esatenolol.Experimental
EsmololThe serum concentration of Lidocaine can be increased when it is combined with Esmolol.Approved
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
Estradiol acetateThe serum concentration of Estradiol acetate can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
Estradiol benzoateThe serum concentration of Estradiol benzoate can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
Estradiol cypionateThe serum concentration of Estradiol cypionate can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
Estradiol dienanthateThe serum concentration of Estradiol dienanthate can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
Estradiol valerateThe serum concentration of Estradiol valerate can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Lidocaine.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Lidocaine.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Lidocaine.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Lidocaine.Approved
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Lidocaine.Approved
EtravirineThe serum concentration of Lidocaine can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Lidocaine.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Lidocaine.Approved
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Lidocaine.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Lidocaine.Approved, Investigational
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Lidocaine.Approved
Fluciclovine (18F)The serum concentration of Fluciclovine (18F) can be increased when it is combined with Lidocaine.Approved
FluconazoleThe metabolism of Lidocaine can be decreased when combined with Fluconazole.Approved, Investigational
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Lidocaine.Approved
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Lidocaine.Approved, Illicit
FluorouracilThe metabolism of Fluorouracil can be decreased when combined with Lidocaine.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Lidocaine.Approved, Vet Approved
FlupentixolThe serum concentration of Flupentixol can be increased when it is combined with Lidocaine.Approved, Investigational, Withdrawn
FlutamideThe metabolism of Flutamide can be decreased when combined with Lidocaine.Approved, Investigational
FluticasoneThe serum concentration of Fluticasone can be increased when it is combined with Lidocaine.Approved, Experimental, Investigational
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Lidocaine.Approved
Fluticasone propionateThe serum concentration of Fluticasone propionate can be increased when it is combined with Lidocaine.Approved
FluvoxamineThe metabolism of Lidocaine can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Lidocaine can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Lidocaine can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Lidocaine can be increased when combined with Fosphenytoin.Approved, Investigational
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Lidocaine.Approved, Investigational
FurafyllineThe metabolism of Furafylline can be decreased when combined with Lidocaine.Experimental
Fusidic AcidThe serum concentration of Lidocaine can be increased when it is combined with Fusidic Acid.Approved, Investigational
GanciclovirThe metabolism of Ganciclovir can be decreased when combined with Lidocaine.Approved, Investigational
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Lidocaine.Approved, Investigational
GenisteinThe metabolism of Genistein can be decreased when combined with Lidocaine.Investigational
GlecaprevirThe serum concentration of Glecaprevir can be increased when it is combined with Lidocaine.Approved, Investigational
Gramicidin DThe serum concentration of Gramicidin D can be increased when it is combined with Lidocaine.Approved
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Lidocaine.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Lidocaine.Approved, Investigational, Withdrawn
GuanabenzThe metabolism of Guanabenz can be decreased when combined with Lidocaine.Approved, Investigational
GuanineThe metabolism of Guanine can be decreased when combined with Lidocaine.Experimental
HyaluronidaseHyaluronidase can cause an increase in the absorption of Lidocaine resulting in an increased serum concentration and potentially a worsening of adverse effects.Approved, Investigational
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Lidocaine.Approved, Vet Approved
HydroxyureaThe serum concentration of Hydroxyurea can be increased when it is combined with Lidocaine.Approved
HypoxanthineThe metabolism of Hypoxanthine can be decreased when combined with Lidocaine.Experimental
IbrutinibThe metabolism of Ibrutinib can be decreased when combined with Lidocaine.Approved
IdelalisibThe metabolism of Lidocaine can be decreased when combined with Idelalisib.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Lidocaine.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Lidocaine.Approved
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Lidocaine.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Lidocaine.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Lidocaine.Approved
IndenololThe serum concentration of Lidocaine can be increased when it is combined with Indenolol.Withdrawn
IndinavirThe metabolism of Lidocaine can be decreased when combined with Indinavir.Approved
Inotuzumab ozogamicinThe serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Lidocaine.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Lidocaine.Approved, Investigational
IsavuconazoleThe serum concentration of Lidocaine can be increased when it is combined with Isavuconazole.Approved, Investigational
IsavuconazoniumThe metabolism of Lidocaine can be decreased when combined with Isavuconazonium.Approved, Investigational
IsoniazidThe metabolism of Lidocaine can be decreased when combined with Isoniazid.Approved, Investigational
ItraconazoleThe metabolism of Lidocaine can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Lidocaine can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
IvosidenibThe serum concentration of Ivosidenib can be increased when it is combined with Lidocaine.Approved, Investigational
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Lidocaine.Approved
KetoconazoleThe metabolism of Lidocaine can be decreased when combined with Ketoconazole.Approved, Investigational
LabetalolThe serum concentration of Lidocaine can be increased when it is combined with Labetalol.Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Lidocaine.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Lidocaine.Approved, Investigational
LandiololThe serum concentration of Lidocaine can be increased when it is combined with Landiolol.Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Lidocaine.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Lidocaine.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Lidocaine.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Lidocaine.Approved, Investigational
LetermovirThe serum concentration of Letermovir can be increased when it is combined with Lidocaine.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Lidocaine.Approved, Investigational
LevobetaxololThe serum concentration of Lidocaine can be increased when it is combined with Levobetaxolol.Approved, Investigational
LevobunololThe serum concentration of Lidocaine can be increased when it is combined with Levobunolol.Approved
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Lidocaine.Approved, Investigational
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Lidocaine.Approved, Investigational
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Lidocaine.Approved, Investigational
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Lidocaine.Approved
LisofyllineThe metabolism of Lisofylline can be decreased when combined with Lidocaine.Investigational
LobeglitazoneThe metabolism of Lidocaine can be decreased when combined with Lobeglitazone.Approved, Investigational
LofexidineThe metabolism of Lofexidine can be decreased when combined with Lidocaine.Approved, Investigational
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Lidocaine.Approved
LopinavirThe metabolism of Lidocaine can be decreased when combined with Lopinavir.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Lidocaine.Approved
LorpiprazoleThe serum concentration of Lidocaine can be increased when it is combined with Lorpiprazole.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Lidocaine.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Lidocaine.Approved, Investigational
LuliconazoleThe serum concentration of Lidocaine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Lidocaine can be increased when combined with Lumacaftor.Approved
LusutrombopagThe serum concentration of Lusutrombopag can be increased when it is combined with Lidocaine.Approved, Investigational
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Lidocaine.Approved, Investigational
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Lidocaine.Approved, Investigational
MelatoninThe metabolism of Melatonin can be decreased when combined with Lidocaine.Approved, Nutraceutical, Vet Approved
MelphalanThe serum concentration of Melphalan can be increased when it is combined with Lidocaine.Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Lidocaine.Investigational, Withdrawn
MepindololThe serum concentration of Lidocaine can be increased when it is combined with Mepindolol.Experimental
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Lidocaine.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Lidocaine.Approved, Vet Approved
MetipranololThe serum concentration of Lidocaine can be increased when it is combined with Metipranolol.Approved
MetoprololThe serum concentration of Lidocaine can be increased when it is combined with Metoprolol.Approved, Investigational
MexiletineThe metabolism of Mexiletine can be decreased when combined with Lidocaine.Approved, Investigational
MianserinThe metabolism of Mianserin can be decreased when combined with Lidocaine.Approved, Investigational
MibefradilThe metabolism of Lidocaine can be decreased when combined with Mibefradil.Investigational, Withdrawn
MiconazoleThe metabolism of Lidocaine can be decreased when combined with Miconazole.Approved, Investigational, Vet Approved
MidostaurinThe metabolism of Lidocaine can be decreased when combined with Midostaurin.Approved, Investigational
MifepristoneThe serum concentration of Lidocaine can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Lidocaine.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Lidocaine.Approved
MitomycinThe serum concentration of Mitomycin can be increased when it is combined with Lidocaine.Approved
MitotaneThe serum concentration of Lidocaine can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Lidocaine.Approved, Investigational
ModafinilThe serum concentration of Lidocaine can be decreased when it is combined with Modafinil.Approved, Investigational
MorphineThe serum concentration of Morphine can be increased when it is combined with Lidocaine.Approved, Investigational
MoxidectinThe serum concentration of Moxidectin can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Lidocaine.Approved, Investigational
NabumetoneThe metabolism of Nabumetone can be decreased when combined with Lidocaine.Approved
NadololThe serum concentration of Lidocaine can be increased when it is combined with Nadolol.Approved
NafcillinThe serum concentration of Lidocaine can be decreased when it is combined with Nafcillin.Approved, Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Lidocaine.Approved
NaloxoneThe metabolism of Lidocaine can be decreased when combined with Naloxone.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Lidocaine.Approved, Vet Approved
NebivololThe serum concentration of Lidocaine can be increased when it is combined with Nebivolol.Approved, Investigational
NefazodoneThe metabolism of Lidocaine can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Lidocaine can be decreased when combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Neostigmine can be increased when it is combined with Lidocaine.Approved, Vet Approved
NetupitantThe serum concentration of Lidocaine can be increased when it is combined with Netupitant.Approved, Investigational
NevirapineThe metabolism of Lidocaine can be increased when combined with Nevirapine.Approved
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Lidocaine.Approved, Investigational
NicotineThe metabolism of Nicotine can be decreased when combined with Lidocaine.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Lidocaine.Approved
NilotinibThe metabolism of Lidocaine can be decreased when combined with Nilotinib.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Lidocaine.Approved
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Lidocaine.Approved
Nitrous acidThe risk or severity of adverse effects can be increased when Lidocaine is combined with Nitrous acid.Approved, Investigational
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Lidocaine.Approved
NordazepamThe metabolism of Nordazepam can be decreased when combined with Lidocaine.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Lidocaine.Approved
OctreotideThe serum concentration of Octreotide can be increased when it is combined with Lidocaine.Approved, Investigational
OdanacatibThe serum concentration of Odanacatib can be increased when it is combined with Lidocaine.Investigational
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Lidocaine.Approved, Investigational
OlaparibThe metabolism of Lidocaine can be decreased when combined with Olaparib.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Lidocaine.Approved, Investigational
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Lidocaine.Approved
OxprenololThe serum concentration of Lidocaine can be increased when it is combined with Oxprenolol.Approved
OxtriphyllineThe metabolism of Oxtriphylline can be decreased when combined with Lidocaine.Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Lidocaine.Approved, Vet Approved
PalbociclibThe serum concentration of Lidocaine can be increased when it is combined with Palbociclib.Approved, Investigational
PaliperidoneThe serum concentration of Paliperidone can be increased when it is combined with Lidocaine.Approved
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Lidocaine.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Lidocaine.Approved
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Lidocaine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Lidocaine.Approved
PefloxacinThe metabolism of Pefloxacin can be decreased when combined with Lidocaine.Approved
Peginterferon alfa-2bThe serum concentration of Lidocaine can be increased when it is combined with Peginterferon alfa-2b.Approved
PenbutololThe serum concentration of Lidocaine can be increased when it is combined with Penbutolol.Approved, Investigational
PentazocineThe serum concentration of Pentazocine can be increased when it is combined with Lidocaine.Approved, Vet Approved
PentobarbitalThe metabolism of Lidocaine can be increased when combined with Pentobarbital.Approved, Investigational, Vet Approved
PentoxifyllineThe metabolism of Pentoxifylline can be decreased when combined with Lidocaine.Approved, Investigational
PerampanelThe metabolism of Perampanel can be decreased when combined with Lidocaine.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Lidocaine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Lidocaine.Withdrawn
PhenobarbitalThe metabolism of Lidocaine can be increased when combined with Phenobarbital.Approved, Investigational
PhenothiazineThe serum concentration of Phenothiazine can be increased when it is combined with Lidocaine.Vet Approved
PhenytoinThe metabolism of Lidocaine can be increased when combined with Phenytoin.Approved, Vet Approved
PibrentasvirThe serum concentration of Pibrentasvir can be increased when it is combined with Lidocaine.Approved, Investigational
PimobendanThe metabolism of Pimobendan can be decreased when combined with Lidocaine.Vet Approved
PimozideThe metabolism of Pimozide can be decreased when combined with Lidocaine.Approved
PindololThe serum concentration of Lidocaine can be increased when it is combined with Pindolol.Approved, Investigational
Pipemidic acidThe metabolism of Pipemidic acid can be decreased when combined with Lidocaine.Experimental
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Lidocaine.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Lidocaine.Approved
PitolisantThe serum concentration of Lidocaine can be decreased when it is combined with Pitolisant.Approved, Investigational
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Lidocaine.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Lidocaine.Approved, Investigational
PosaconazoleThe metabolism of Lidocaine can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PractololThe serum concentration of Lidocaine can be increased when it is combined with Practolol.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Lidocaine.Approved
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Lidocaine.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Lidocaine.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Lidocaine.Approved, Vet Approved
PrilocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Prilocaine.Approved
PrimidoneThe metabolism of Lidocaine can be increased when combined with Primidone.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Lidocaine.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Lidocaine.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Lidocaine.Approved, Vet Approved
PropafenoneThe serum concentration of Lidocaine can be increased when it is combined with Propafenone.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Lidocaine.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Lidocaine can be increased when it is combined with Propranolol.Approved, Investigational
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Lidocaine.Approved
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Lidocaine.Approved
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Lidocaine.Approved, Investigational
QuinineThe metabolism of Lidocaine can be increased when combined with Quinine.Approved
RamelteonThe metabolism of Ramelteon can be decreased when combined with Lidocaine.Approved, Investigational
RamosetronThe metabolism of Ramosetron can be decreased when combined with Lidocaine.Approved, Investigational
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Lidocaine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Lidocaine.Approved, Investigational
RasagilineThe metabolism of Rasagiline can be decreased when combined with Lidocaine.Approved
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Lidocaine.Approved
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Lidocaine.Approved, Investigational
ResveratrolThe metabolism of Resveratrol can be decreased when combined with Lidocaine.Approved, Experimental, Investigational
Rhodamine 6GThe serum concentration of Rhodamine 6G can be increased when it is combined with Lidocaine.Experimental
RifampicinThe metabolism of Lidocaine can be increased when combined with Rifampicin.Approved
RifamycinThe metabolism of Lidocaine can be increased when combined with Rifamycin.Investigational
RifapentineThe metabolism of Lidocaine can be increased when combined with Rifapentine.Approved, Investigational
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Lidocaine.Approved, Investigational
RiluzoleThe metabolism of Riluzole can be decreased when combined with Lidocaine.Approved, Investigational
RimexoloneThe metabolism of Lidocaine can be increased when combined with Rimexolone.Approved
RisperidoneThe metabolism of Lidocaine can be decreased when combined with Risperidone.Approved, Investigational
RitonavirThe metabolism of Lidocaine can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Lidocaine.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Lidocaine.Approved, Investigational
RopiniroleThe metabolism of Lidocaine can be decreased when combined with Ropinirole.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Lidocaine.Approved
RucaparibThe serum concentration of Rucaparib can be increased when it is combined with Lidocaine.Approved, Investigational
SaquinavirSaquinavir may increase the arrhythmogenic activities of Lidocaine.Approved, Investigational
SarilumabThe therapeutic efficacy of Lidocaine can be decreased when used in combination with Sarilumab.Approved, Investigational
SelegilineThe metabolism of Selegiline can be decreased when combined with Lidocaine.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Lidocaine.Approved
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Lidocaine.Approved
SiltuximabThe serum concentration of Lidocaine can be decreased when it is combined with Siltuximab.Approved, Investigational
SimeprevirThe serum concentration of Lidocaine can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Lidocaine.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Lidocaine.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Lidocaine.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Lidocaine.Approved
SomatostatinThe serum concentration of Somatostatin can be increased when it is combined with Lidocaine.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Lidocaine.Approved, Investigational
SotalolThe serum concentration of Lidocaine can be increased when it is combined with Sotalol.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Lidocaine.Approved, Investigational
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Lidocaine.Experimental
St. John's WortThe serum concentration of Lidocaine can be decreased when it is combined with St. John's Wort.Approved, Investigational, Nutraceutical
StanoloneThe serum concentration of Stanolone can be increased when it is combined with Lidocaine.Illicit, Investigational
Stanolone acetateThe serum concentration of Stanolone acetate can be increased when it is combined with Lidocaine.Experimental
StiripentolThe serum concentration of Lidocaine can be increased when it is combined with Stiripentol.Approved
SumatriptanThe serum concentration of Sumatriptan can be increased when it is combined with Lidocaine.Approved, Investigational
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Lidocaine.Approved, Investigational
TacrineThe serum concentration of Tacrine can be increased when it is combined with Lidocaine.Investigational, Withdrawn
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Lidocaine.Approved, Investigational
TalinololThe serum concentration of Lidocaine can be increased when it is combined with Talinolol.Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Lidocaine.Approved
TasimelteonThe metabolism of Tasimelteon can be decreased when combined with Lidocaine.Approved, Investigational
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Lidocaine.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lidocaine.Approved, Investigational
Technetium Tc-99m tilmanoceptLidocaine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.Approved, Investigational
TegafurThe metabolism of Tegafur can be decreased when combined with Lidocaine.Approved, Investigational
TelaprevirThe risk or severity of adverse effects can be increased when Telaprevir is combined with Lidocaine.Approved, Withdrawn
TelithromycinThe metabolism of Lidocaine can be decreased when combined with Telithromycin.Approved
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Lidocaine.Approved
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Lidocaine.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Lidocaine.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Lidocaine.Approved, Withdrawn
TeriflunomideThe serum concentration of Lidocaine can be decreased when it is combined with Teriflunomide.Approved
TertatololThe serum concentration of Lidocaine can be increased when it is combined with Tertatolol.Experimental
Testosterone propionateThe serum concentration of Testosterone propionate can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved, Withdrawn
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Lidocaine.Approved, Vet Approved
TheobromineThe metabolism of Theobromine can be decreased when combined with Lidocaine.Approved, Investigational
TheophyllineThe metabolism of Lidocaine can be decreased when combined with Theophylline.Approved
ThioridazineThe metabolism of Thioridazine can be decreased when combined with Lidocaine.Approved, Withdrawn
ThiothixeneThe metabolism of Thiothixene can be decreased when combined with Lidocaine.Approved
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Lidocaine.Approved
TimololThe serum concentration of Lidocaine can be increased when it is combined with Timolol.Approved
TipranavirThe metabolism of Lidocaine can be decreased when combined with Tipranavir.Approved, Investigational
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Lidocaine.Approved, Investigational
TocilizumabThe serum concentration of Lidocaine can be decreased when it is combined with Tocilizumab.Approved
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Lidocaine.Approved
TopiramateThe serum concentration of Topiramate can be increased when it is combined with Lidocaine.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Lidocaine.Approved, Investigational
ToremifeneThe metabolism of Toremifene can be decreased when combined with Lidocaine.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Lidocaine.Approved, Investigational
TriamtereneThe metabolism of Triamterene can be decreased when combined with Lidocaine.Approved
TrifluoperazineThe serum concentration of Trifluoperazine can be increased when it is combined with Lidocaine.Approved, Investigational
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Lidocaine.Approved
TroleandomycinThe metabolism of Lidocaine can be decreased when combined with Troleandomycin.Approved
UbidecarenoneThe serum concentration of Ubidecarenone can be increased when it is combined with Lidocaine.Approved, Investigational, Nutraceutical
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Lidocaine.Approved
VadimezanThe metabolism of Vadimezan can be decreased when combined with Lidocaine.Investigational
ValinomycinThe serum concentration of Valinomycin can be increased when it is combined with Lidocaine.Experimental
ValspodarThe serum concentration of Valspodar can be increased when it is combined with Lidocaine.Investigational
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Lidocaine.Approved
VelpatasvirThe serum concentration of Velpatasvir can be increased when it is combined with Lidocaine.Approved, Investigational
VemurafenibThe risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Lidocaine.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Lidocaine.Approved, Investigational
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Lidocaine.Approved
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Lidocaine.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Lidocaine.Approved
VincristineThe excretion of Vincristine can be decreased when combined with Lidocaine.Approved, Investigational
VinflunineThe serum concentration of Vinflunine can be increased when it is combined with Lidocaine.Approved, Investigational
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Lidocaine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Lidocaine.Approved, Investigational
VoriconazoleThe metabolism of Lidocaine can be decreased when combined with Voriconazole.Approved, Investigational
VoxilaprevirThe serum concentration of Voxilaprevir can be increased when it is combined with Lidocaine.Approved, Investigational
WarfarinThe metabolism of Warfarin can be decreased when combined with Lidocaine.Approved
XanthineThe metabolism of Xanthine can be decreased when combined with Lidocaine.Experimental
ZafirlukastThe metabolism of Lidocaine can be decreased when combined with Zafirlukast.Approved, Investigational
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Lidocaine.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Lidocaine.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Lidocaine can be decreased when combined with Ziprasidone.Approved
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Lidocaine.Approved, Investigational
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Lidocaine.Approved
ZotepineThe metabolism of Zotepine can be decreased when combined with Lidocaine.Approved, Investigational, Withdrawn
ZucapsaicinThe metabolism of Lidocaine can be decreased when combined with Zucapsaicin.Approved, Investigational
Food Interactions
Not Available

References

Synthesis Reference
US2441498A
General References
  1. Khaliq W, Alam S, Puri N: Topical lidocaine for the treatment of postherpetic neuralgia. Cochrane Database Syst Rev. 2007 Apr 18;(2):CD004846. [PubMed:17443559]
  2. Thomson PD, Melmon KL, Richardson JA, Cohn K, Steinbrunn W, Cudihee R, Rowland M: Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans. Ann Intern Med. 1973 Apr;78(4):499-508. [PubMed:4694036]
  3. Geha PY, Baliki MN, Chialvo DR, Harden RN, Paice JA, Apkarian AV: Brain activity for spontaneous pain of postherpetic neuralgia and its modulation by lidocaine patch therapy. Pain. 2007 Mar;128(1-2):88-100. Epub 2006 Oct 25. [PubMed:17067740]
  4. Hines R, Keaney D, Moskowitz MH, Prakken S: Use of lidocaine patch 5% for chronic low back pain: a report of four cases. Pain Med. 2002 Dec;3(4):361-5. [PubMed:15099246]
External Links
Human Metabolome Database
HMDB0014426
KEGG Drug
D00358
KEGG Compound
C07073
PubChem Compound
3676
PubChem Substance
46505060
ChemSpider
3548
BindingDB
50017662
ChEBI
6456
ChEMBL
CHEMBL79
Therapeutic Targets Database
DAP000121
PharmGKB
PA450226
IUPHAR
2623
Guide to Pharmacology
GtP Drug Page
HET
LQZ
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Lidocaine
ATC Codes
C01BB01 — LidocaineN01BB02 — LidocaineD04AB01 — LidocaineR02AD02 — LidocaineS02DA01 — LidocaineC05AD01 — LidocaineS01HA07 — LidocaineN01BB52 — Lidocaine, combinations
AHFS Codes
  • 84:08.00 — Antipruritics and Local Anesthetics
  • 24:04.00 — Cardiac Drugs
  • 24:04.04.08 — Class Ib Antiarrythmics
  • 72:00.00 — Local Anesthetics
  • 52:16.00 — Local Anesthetics
PDB Entries
3jqz / 3ttr
FDA label
Download (548 KB)
MSDS
Download (74.6 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedBasic ScienceMorton's neuralgia1
0CompletedHealth Services ResearchPain1
0CompletedSupportive CareAddition of Hyalase to Local Anesthetic in Scalp Block1
0CompletedSupportive CareCutaneous Abscess / Pain1
0CompletedTreatmentChorionic Villi Sampling1
0CompletedTreatmentTemporomandibular Disorders1
0CompletedTreatmentTinnitus1
0Not Yet RecruitingSupportive CareBariatric Surgery Candidate1
0Not Yet RecruitingTreatmentNeoplasms, Lung / Pleural Effusion, Malignant1
0RecruitingOtherHeat Effect1
0RecruitingPreventionColorectal Cancers1
0RecruitingTreatmentComplex Regional Pain Syndrome (CRPS)1
0RecruitingTreatmentSurgical Anesthesia, Cesarean Section1
0WithdrawnPreventionHemodynamics Instability1
1Active Not RecruitingOtherSurgery, Colorectal1
1CompletedNot AvailableHealthy Volunteers1
1CompletedBasic ScienceDrug-induced QT Interval Prolongation / Pharmacodynamics / Pharmacokinetics1
1CompletedBasic ScienceHealthy Volunteers2
1CompletedBasic ScienceNociceptive Pain / Peripheral Neuropathic Pain1
1CompletedHealth Services ResearchAnaesthesia therapy1
1CompletedPreventionCancer, Breast1
1CompletedPreventionIntradermal Electroporation1
1CompletedPreventionOther Preterm Infants1
1CompletedSupportive CareEtomidate Overdose of Undetermined Intent1
1CompletedTreatment"Lost" IUD / Lost IUD1
1CompletedTreatmentCoughing1
1CompletedTreatmentFibromyalgia / Pain, Chronic1
1CompletedTreatmentHyperalgesia / Pain1
1CompletedTreatmentIpsilateral Shoulder Pain1
1CompletedTreatmentNeoplasms, Cystic, Mucinous, and Serous1
1CompletedTreatmentPain Management / Pregnancy Termination1
1CompletedTreatmentProvoked Vestibulodynia / Provoked, Localized Vulvodynia / Vulvar Vestibulitis / Vulvodynia1
1CompletedTreatmentRadicular syndrome / Sciatica1
1CompletedTreatmentTopical Anesthesia1
1Not Yet RecruitingSupportive CareLocal Anesthesia / Neoplasms, Brain1
1Not Yet RecruitingTreatmentPostoperative pain1
1Not Yet RecruitingTreatmentPulmonary Arterial Hypertension (PAH)1
1RecruitingTreatmentCraniotomy / High Blood Pressure (Hypertension)1
1RecruitingTreatmentIntermetatarsal Neuroma1
1RecruitingTreatmentKnee Osteoarthritis (Knee OA)1
1RecruitingTreatmentPompe's Disease1
1TerminatedTreatmentAcute-onset Herpes Zoster Pain1
1TerminatedTreatmentPain, Neuropathic1
1, 2CompletedPreventionHemodynamic Changes Due to Propofol Injection / Pain Due to Propofol Injection1
1, 2CompletedSupportive CareAnalgesia1
1, 2CompletedTreatmentKnee Osteoarthritis (Knee OA)1
1, 2CompletedTreatmentLung Cancers / Unspecified Adult Solid Tumor, Protocol Specific1
1, 2RecruitingPreventionBariatric Surgery Candidate / BMI >30 kg/m21
1, 2RecruitingPreventionChemotherapy-induced Peripheral Neuropathy (CIPN) / Colorectal Cancers / Neuropathy, Painful1
1, 2TerminatedPreventionPain1
1, 2Unknown StatusTreatmentAnaesthesia therapy1
1, 2WithdrawnTreatmentColorectal Disorders1
1, 2WithdrawnTreatmentInjuries and Wounds1
1, 2WithdrawnTreatmentPostoperative Pain Management After Total Hip Arthroplasty1
2CompletedBasic ScienceDiabetic Neuropathic Pain1
2CompletedPreventionDysmenorrhea1
2CompletedPreventionHyperalgesia / Knee Joint Osteoarthrosis / Severe Movement Related Pain1
2CompletedPreventionRotator Cuff Syndrome1
2CompletedPreventionPostoperative paralytic ileus1
2CompletedSupportive CareDental Anesthesia Efficacy1
2CompletedSupportive CareDiverticulitis / Inflammatory Bowel Diseases (IBD) / Malignant Neoplasm of Colon1
2CompletedSupportive CareMucositis1
2CompletedSupportive CareOral Mucositis1
2CompletedSupportive CareSupratentorial Craniotomy Dysfunction1
2CompletedTreatmentAllodynia / Central Neuropathic Pain / Spinal Cord Injuries (SCI)1
2CompletedTreatmentAnaesthesia therapy / Local Infiltration1
2CompletedTreatmentAnesthetics, Local / Pain / Venipuncture1
2CompletedTreatmentCarpal Tunnel Syndrome (CTS)1
2CompletedTreatmentChronic Low Back Pain (CLBP)1
2CompletedTreatmentChronic Pain Syndrome / Prostatitis1
2CompletedTreatmentDysmenorrhea / Endometriosis1
2CompletedTreatmentFascicular Block / Latency Period / Motor Activities / Postoperative pain1
2CompletedTreatmentFeeling Anxious / Pain1
2CompletedTreatmentHealthy Volunteers1
2CompletedTreatmentHemorrhoids1
2CompletedTreatmentHip Pain Etiology Unknown1
2CompletedTreatmentIrritable Bowel Syndrome (IBS)1
2CompletedTreatmentKnee Osteoarthritis (Knee OA)2
2CompletedTreatmentLeiomyomas1
2CompletedTreatmentLocal Anesthesia1
2CompletedTreatmentLow Back Pain (LBP)1
2CompletedTreatmentMyofascial Pain Syndromes1
2CompletedTreatmentObesity, Morbid / Postoperative pain1
2CompletedTreatmentPain4
2CompletedTreatmentPain, Neuropathic / Vasoocclusive Sickle Cell Crises Pains1
2CompletedTreatmentPatellar Tendinopathy1
2CompletedTreatmentPostherpetic Neuralgia2
2CompletedTreatmentPostoperative pain1
2CompletedTreatmentShoulder Impingement Syndrome1
2CompletedTreatmentShoulder Pain1
2CompletedTreatmentShoulder Pain / Strokes1
2CompletedTreatmentUrinary Tract Infections (UTIs)1
2CompletedTreatmentVulvodynia1
2Enrolling by InvitationPreventionNormal Pulp/ Pulpitis1
2Not Yet RecruitingPreventionIntubations / Stellate Ganglion1
2Not Yet RecruitingTreatmentAllodynic Symptoms / Localized Neuropathic Pain1
2Not Yet RecruitingTreatmentAnesthetics, Local1
2Not Yet RecruitingTreatmentPost-Dural Puncture Headache1
2Not Yet RecruitingTreatmentUrethral Strictures1
2RecruitingPreventionIntraoperative Bleeding1
2RecruitingSupportive CareCancer, Breast1
2RecruitingTreatmentBladder Pain Syndrome / Interstitial Cystitis1
2RecruitingTreatmentDependence, Cocaine1
2RecruitingTreatmentDiabetic Polyneuropathy / Peripheral Neuropathy / Postherpetic Neuralgia1
2RecruitingTreatmentElective Cesarean Delivery / Valve Heart Disease1
2RecruitingTreatmentInterstitial Cystitis / Painful Bladder Syndrome (PBS)1
2TerminatedSupportive CareNeoplasms, Malignant1
2TerminatedTreatmentDry Macular Degeneration1
2TerminatedTreatmentPruritus1
2TerminatedTreatmentVulvar Vestibulitis1
2Unknown StatusPreventionCancer, Breast1
2Unknown StatusTreatmentShoulder Pain1
2WithdrawnTreatmentCerebrovascular Accidents / Strokes1
2WithdrawnTreatmentNeoplasms / Pain1
2WithdrawnTreatmentPain1
2WithdrawnTreatmentPhantom Limb Pain (PLP) / Primary/Secondary Scar Hyperalgesia1
2, 3CompletedOtherLocal Anesthesia1
2, 3CompletedPreventionPain Relief During Prostate Biopsy1
2, 3CompletedTreatmentCardiac Catheterizations / Spasms1
2, 3CompletedTreatmentHerpes Zoster Pain1
2, 3CompletedTreatmentInterferential Current Drug Delivery1
2, 3CompletedTreatmentInterstitial Lung Disease (ILD) / Lung Cancers / Sarcoidosis / Tuberculosis1
2, 3CompletedTreatmentPain and Anxiety1
2, 3CompletedTreatmentPain, Acute1
2, 3CompletedTreatmentPain / Surgical Abortion1
2, 3CompletedTreatmentPostcesarean Pain Relief1
2, 3CompletedTreatmentPostoperative pain1
2, 3Not Yet RecruitingPreventionDiscomfort / Pain1
2, 3Not Yet RecruitingTreatmentCarpal Tunnel Syndrome (CTS)1
2, 3RecruitingPreventionHysterectomy / Myomectomy1
2, 3RecruitingTreatmentPain1
2, 3SuspendedSupportive CareCancer-related Pain1
2, 3TerminatedTreatmentElective Surgical Procedure / Surgery, Colorectal1
2, 3Unknown StatusPreventionWe Focus on the Pain of Venipuncture and Intravenous Cannulation1
2, 3Unknown StatusTreatmentAchilles Tendinopathy / Achilles Tendon Enthesopathy / Insertional Achilles Tendinopathy / Mid-Portion Achilles Tendinopathy / Non-Insertional Achilles Tendinopathy1
2, 3Unknown StatusTreatmentHemorrhoids1
3Active Not RecruitingTreatmentContraception / Lidocaine1
3Active Not RecruitingTreatmentPain, Chronic1
3Active Not RecruitingTreatmentUndernutrition1
3CompletedNot AvailableLocal Anesthesia1
3CompletedBasic ScienceBMI >30 kg/m2 / Post-gastrointestinal bypass surgery1
3CompletedDiagnosticGynecologic Diseases1
3CompletedDiagnosticPostoperative pain1
3CompletedPreventionBariatric Surgical Pain1
3CompletedPreventionChronic Post-surgical Pain / Post-mastectomy Pain Syndrome1
3CompletedPreventionElective Major Abdominal Surgery1
3CompletedPreventionRadiation Dermatitis1
3CompletedSupportive CareAnalgesia1
3CompletedSupportive CarePain / Tiredness1
3CompletedSupportive CarePain / Unspecified Adult Solid Tumor, Protocol Specific1
3CompletedSupportive CareProcedural Pain Relief1
3CompletedSupportive CareSubtenon Anesthesia1
3CompletedTreatmentAbdominal Pain (AP) / Gastroesophageal Reflux Disease / Indigestion / Intestinal Malabsorption1
3CompletedTreatmentAnaesthesia therapy2
3CompletedTreatmentAnkle Sprains1
3CompletedTreatmentBiceps Tendonitis1
3CompletedTreatmentCardiac Arrest1
3CompletedTreatmentChronic Low Back Pain (CLBP)1
3CompletedTreatmentDiabetes Mellitus (DM)1
3CompletedTreatmentFacial Wrinkles at the Nasolabial Folds1
3CompletedTreatmentForearm and Arm Surgery1
3CompletedTreatmentInguinal Pain1
3CompletedTreatmentIrreversible Pulpitis1
3CompletedTreatmentLidocaine Adverse Reaction / Prilocaine Adverse Reaction1
3CompletedTreatmentMastectomy1
3CompletedTreatmentModerate or Severe Submental Fullness1
3CompletedTreatmentNeoplasms, Colorectal1
3CompletedTreatmentNonviable Pregnancy1
3CompletedTreatmentPain11
3CompletedTreatmentPain Management, Cervical Preparation1
3CompletedTreatmentPain Teeth1
3CompletedTreatmentPeripheral Neuropathy1
3CompletedTreatmentPharyngitis1
3CompletedTreatmentPostoperative pain4
3CompletedTreatmentProcedural Pain1
3CompletedTreatmentSpinal Anaesthesia1
3CompletedTreatmentPostoperative paralytic ileus1
3Not Yet RecruitingTreatmentBariatric Surgery Candidate / Obesity, Morbid1
3Not Yet RecruitingTreatmentMigraines1
3RecruitingDiagnosticNeurocostal neuralgia / Peripheral Neuropathic Pain1
3RecruitingPreventionAdjunct to general anesthesia therapy / Anaesthesia therapy / Analgesics / Analgesics, Opioid / Dexmedetomidine / Gabapentin / Ketamine / Lidocaine / Narcotics / Obstructive Sleep Apnea of Child / Oximetry, Pulse / Pathologic Processes / Physiologic Effects of Drugs / Postoperative Complications / Respiratory Depression / Sleep Disordered Breathing (SDB) / Tonsillectomy1
3RecruitingPreventionLabour Pain1
3RecruitingSupportive CarePain1
3RecruitingTreatmentAcute Musculoskeletal Disease / Emergency / Pain, Acute / Sprains / Sprains and Strains / Traumas / Traumatic Injuries1
3RecruitingTreatmentCancers / Pain With Neuropathic Component1
3RecruitingTreatmentCarcinologic Ear, Nose, and Throat (ENT) Surgery1
3RecruitingTreatmentContraception1
3RecruitingTreatmentInguinal Hernias / Local Anesthesia / Sedation, Conscious1
3RecruitingTreatmentLow Back Pain (LBP) / Modic I Discopathy1
3RecruitingTreatmentPain, Chronic1
3RecruitingTreatmentPelvic Pain1
3RecruitingTreatmentPostoperative pain1
3RecruitingTreatmentStrokes1
3RecruitingTreatmentUterine Hemorrhage1
3TerminatedPreventionTransient Neurologic Syndrome1
3TerminatedTreatmentAnalgesia, Postoperative / Opioid Free Anaesthesia1
3TerminatedTreatmentBone Marrow Diseases / Pain1
3TerminatedTreatmentBursitis / Periarthritis1
3TerminatedTreatmentCarpal Tunnel Syndrome (CTS)1
3Unknown StatusNot AvailableInduction of Total Intravenous General Anesthesia1
3Unknown StatusTreatmentCancers / Pain1
3Unknown StatusTreatmentFibromyalgia1
3Unknown StatusTreatmentHealthy Volunteers1
3WithdrawnTreatmentPain1
3WithdrawnTreatmentParathyroid Diseases1
4Active Not RecruitingPreventionHemodynamics Instability1
4Active Not RecruitingSupportive CareNerve Monitoring / Thyroidectomy1
4Active Not RecruitingTreatmentAnaesthesia therapy2
4Active Not RecruitingTreatmentCarpal Tunnel Syndrome (CTS)1
4Active Not RecruitingTreatmentCystoscopy / Lidocaine / Pain Perception1
4CompletedNot AvailableAnaesthesia therapy1
4CompletedNot AvailableAnaesthesia / Caudal epidural block therapy / Orthopaedic Disorders1
4CompletedNot AvailableNeuromuscular Block1
4CompletedNot AvailablePain of Anesthesia at Breast Biopsy1
4CompletedNot AvailablePeriodontal Diseases1
4CompletedNot AvailableUterine Leiomyomas1
4CompletedBasic ScienceHunger1
4CompletedBasic ScienceLow Back Pain (LBP)1
4CompletedOtherPain1
4CompletedPreventionAnesthesia of Mucous Membrane1
4CompletedPreventionCardiovascular Morbidity / Intubation Complications1
4CompletedPreventionChildbirth / Parturients1
4CompletedPreventionEsophagogastroduodenoscopy1
4CompletedPreventionGeneral Surgery / Pain1
4CompletedPreventionImproving Quality of Life1
4CompletedPreventionLaminectomy1
4CompletedPreventionNeonatal Infections1
4CompletedPreventionOpioid Consumption, Postoperative / Postoperative Fatigue / Postoperative pain1
4CompletedPreventionPain2
4CompletedPreventionPain on Injection of Propofol,Lidocaine, Alkalinized Lidocaine1
4CompletedPreventionPost-Operative Pain1
4CompletedPreventionPostoperative pain3
4CompletedPreventionThroat Pain1
4CompletedScreeningPostoperative pain1
4CompletedSupportive CareAnaesthesia therapy1
4CompletedSupportive CareArterial Catheterization1
4CompletedSupportive CareCervical Pain / Pelvic Pain1
4CompletedSupportive CareCognitive Function Abnormal / Intraoperative Monitoring / Vitreoretinal Surgery1
4CompletedSupportive CareColonoscopy1
4CompletedSupportive CareElectrodiagnosis1
4CompletedSupportive CareIntravenous Anesthetic Interaction "Unrecognized Condition" / Intravenous Anesthetic Interaction Unrecognized Condition1
4CompletedSupportive CareLeukemias / Non Hodgkin Lymphoma (NHL)1
4CompletedSupportive CarePain5
4CompletedSupportive CarePain, Neuropathic / Postmastectomy Pain1
4CompletedSupportive CareQuality of Ocular Akinesia (Onset and Duration)1
4CompletedSupportive CareSedation, Conscious1
4CompletedTreatmentAcute and Chronic Non-radicular LBP1
4CompletedTreatmentAdhesive Capsulitis1
4CompletedTreatmentAdverse Effects1
4CompletedTreatmentAnalgesia / IUD Insertion1
4CompletedTreatmentAnalgesic Requirement / Inadequate or Impaired Respiratory Function / Postoperative pain / Return of Bowel Activity / Stress Response1
4CompletedTreatmentBMI >30 kg/m21
4CompletedTreatmentBack Pain / Cervical Pain1
4CompletedTreatmentBenign Prostatic Hyperplasia (BPH)1
4CompletedTreatmentBimalleolar Fractures of the Ankle / Post Operative Analgesia Duration / Saphenous Nerve Block / Sciatic Nerve Block1
4CompletedTreatmentBlock Level / Gastrointestinal Surgery / Target Controlled Infusion (TCI) / Thoracic Epidural Anesthesia1
4CompletedTreatmentCanal Syndrome / Pudendal Neuralgia1
4CompletedTreatmentCarpal Tunnel Syndrome (CTS) / Complex Regional Pain Syndrome (CRPS) / Diabetic Neuropathies / HIV Neuropathy / Idiopathic Sensory Neuropathy / Peripheral Neuropathy / Postherpetic Neuralgia1
4CompletedTreatmentCarpal Tunnel Syndrome (CTS) / Trigger Finger1
4CompletedTreatmentChronic Calculous Cholecystitis1
4CompletedTreatmentChronic Cough (CC)1
4CompletedTreatmentChronic Low Back Pain (CLBP)1
4CompletedTreatmentComplication of Injection / Pain1
4CompletedTreatmentConscious Sedation Failure During Procedure1
4CompletedTreatmentCoronary Artery Disease1
4CompletedTreatmentDermatitis Papillaris Capillitii / Tattooing1
4CompletedTreatmentDiabetes Mellitus (DM)1
4CompletedTreatmentDiabetes Mellitus (DM) / Periodontitis, Chronic1
4CompletedTreatmentDiabetic Neuropathies / Low Back Pain (LBP) / Postherpetic Neuralgia1
4CompletedTreatmentDisseminated Sclerosis1
4CompletedTreatmentEpicondylitis of the Elbow1
4CompletedTreatmentEpicondylitis, Lateral Humeral / Lateral Epicondylitis1
4CompletedTreatmentFeeling Anxious / Nausea / Pain1
4CompletedTreatmentFissure;Anal / Fistula;Rectal / Hemorrhoids1
4CompletedTreatmentGall Stone Disease1
4CompletedTreatmentHallux Valgus1
4CompletedTreatmentHealthy Volunteers1
4CompletedTreatmentIUD Insertion1
4CompletedTreatmentIV Insertion Pain1
4CompletedTreatmentInjection Site Irritation1
4CompletedTreatmentInjections, Spinal / Morphine / Patients Satisfaction / Prostatectomy1
4CompletedTreatmentAdjunct to general anesthesia therapy / Intravenous Anesthesia1
4CompletedTreatmentIntravenous Injections1
4CompletedTreatmentIrreversible Pulpitis / Pain1
4CompletedTreatmentKnee Arthroplasty, Total1
4CompletedTreatmentKnee Osteoarthritis (Knee OA)1
4CompletedTreatmentLocal Anesthesia1
4CompletedTreatmentLocal Anesthesia for Peripheral Intravenous Catheterization / Pain1
4CompletedTreatmentLocal Anesthesia of the Skin2
4CompletedTreatmentLow Back Pain (LBP) / Spinal Stenosis1
4CompletedTreatmentLung Cancers1
4CompletedTreatmentMigrainous Headache1
4CompletedTreatmentMyofascial Pain Syndrome / Myofascial Trigger Point Pain / Pain / Painful musculoskeletal conditions1
4CompletedTreatmentNeuromuscular Block1
4CompletedTreatmentNose Deformities, Acquired1
4CompletedTreatmentOpen Reduction Internal Fixation(ORIF) of Lateral Malleolus1
4CompletedTreatmentNeurocostal neuralgia / Opioid-Related Disorders1
4CompletedTreatmentPain6
4CompletedTreatmentPain Associated With Epidural Needle Insertion1
4CompletedTreatmentPain on IV Injection of Propofol1
4CompletedTreatmentPain, Acute1
4CompletedTreatmentPain, Chronic1
4CompletedTreatmentPain, Neuropathic1
4CompletedTreatmentPain / Prophylaxis against postoperative nausea and vomiting1
4CompletedTreatmentOr Peripheral Nerve Injury (PNI) / Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN)1
4CompletedTreatmentPersistent Post-menpausal Bleeding / Uterine Cancers / Uterine Leiomyomas1
4CompletedTreatmentPostoperative Sore Throat, Cough, Hoarseness1
4CompletedTreatmentPostoperative pain2
4CompletedTreatmentPostoperative pain / Postoperative paralytic ileus / Prophylaxis against postoperative nausea and vomiting1
4CompletedTreatmentAdjunct to general anesthesia therapy / Propofol Target-controlled Infusion / Thoracic Epidural Anesthesia1
4CompletedTreatmentSedation, Conscious1
4CompletedTreatmentSpinal Anaesthesia1
4CompletedTreatmentThermal Burns1
4CompletedTreatmentTinnitus1
4CompletedTreatmentTolerance1
4CompletedTreatmentTopical Anesthesia1
4CompletedTreatmentGallstone formation1
4Enrolling by InvitationTreatmentAnesthesia Complication / Hemodynamics Instability / Ileus paralytic / Nausea / Postoperative pain / Vomiting1
4Enrolling by InvitationTreatmentLocal Anesthesia1
4Enrolling by InvitationTreatmentNonspecific Pain Post Traumatic Injury1
4Enrolling by InvitationTreatmentPain1
4Not Yet RecruitingOtherLocal Anesthesia / Pain1
4Not Yet RecruitingPreventionCritical Illness1
4Not Yet RecruitingPreventionPain During Hystroscopy1
4Not Yet RecruitingPreventionNeurocostal neuralgia / Pain, Acute / Pain, Chronic1
4Not Yet RecruitingPreventionStress Related Disorder1
4Not Yet RecruitingPreventionThroat Pain1
4Not Yet RecruitingPreventionUrinary Catheter Discomfort in Surgical Patients1
4Not Yet RecruitingSupportive CarePain / Satisfaction, Consumer1
4Not Yet RecruitingTreatmentAnesthesia, Dental / Postoperative pain1
4Not Yet RecruitingTreatmentCervical Radiculitis / Pain1
4Not Yet RecruitingTreatmentIUD Insertion Complication1
4Not Yet RecruitingTreatmentIntravenous Lidocaine and Immunity1
4Not Yet RecruitingTreatmentLaparoscopic Colon Resection / Perioperative analgesia1
4Not Yet RecruitingTreatmentLimb Deformities1
4Not Yet RecruitingTreatmentLocal Anesthesia / Spinal Diseases1
4Not Yet RecruitingTreatmentOrthopedic Procedures1
4Not Yet RecruitingTreatmentPain1
4Not Yet RecruitingTreatmentPain, Acute1
4Not Yet RecruitingTreatmentPain, Neuropathic1
4Not Yet RecruitingTreatmentRadiculopathy, Cervical2
4Not Yet RecruitingTreatmentSpinal Diseases1
4RecruitingBasic ScienceHealthy Volunteers1
4RecruitingDiagnosticFemale Infertility of Tubal Origin1
4RecruitingOtherPeriodontitis1
4RecruitingPreventionAnginal Pain / Coronary Artery Disease / Radial Artery Spasm1
4RecruitingPreventionThroat Disorder1
4RecruitingSupportive CareAnesthesia, Intravenous; Surgery, Plastic1
4RecruitingSupportive CareColon Diverticulosis / Colonic Neoplasms / Constipation Drug Induced / Diverticulitis, Colonic / Ileus / Ileus paralytic / Ileus; Mechanical / Malignant Neoplasm of Colon / Occasional Constipation / Postoperative pain / Rectum Cancer / Rectum Neoplasm1
4RecruitingTreatmentAbdominal Pain (AP)1
4RecruitingTreatmentAcute Low Back Pain1
4RecruitingTreatmentAnaesthesia therapy / Analgesia / Conscious Sedation Failure During Procedure1
4RecruitingTreatmentAnalgesia / Urolithiasis1
4RecruitingTreatmentArrhythmias Ventricular1
4RecruitingTreatmentCerebrospinal Fluid Leaks / Postdural Puncture Headache / Spinal; Puncture, Complications, Headache1
4RecruitingTreatmentCicatrix1
4RecruitingTreatmentLateral Epicondylitis1
4RecruitingTreatmentLow Back Pain (LBP)1
4RecruitingTreatmentMigraines1
4RecruitingTreatmentMyofascial Pain Syndrome1
4RecruitingTreatmentOpioids Use1
4RecruitingTreatmentOpioids Use / Postoperative pain1
4RecruitingTreatmentOveractive Bladder / Urinary Incontinence (UI) / Voiding Disorders1
4RecruitingTreatmentPain1
4RecruitingTreatmentPain, Acute / Rib Fracture Multiple / Trauma Chest1
4RecruitingTreatmentPain, Radiating1
4RecruitingTreatmentPost Operative Pain1
4RecruitingTreatmentPostoperative Pain Management1
4RecruitingTreatmentPostoperative pain3
4RecruitingTreatmentSedation therapy1
4RecruitingTreatmentCaudal epidural block therapy / Transurethral Resection / Urinary Bladder Neoplasms1
4RecruitingTreatmentPost-pancreatectomy1
4SuspendedNot AvailableOnset and Duration of a Digital Nerve Block1
4SuspendedBasic SciencePain1
4SuspendedSupportive CareLocal Anesthesia / Wounds1
4TerminatedDiagnosticPain1
4TerminatedPreventionNausea / Occasional Constipation / Pain / Vomiting1
4TerminatedPreventionPain1
4TerminatedSupportive CarePain1
4TerminatedTreatmentAbscesses1
4TerminatedTreatmentArthritis Multiple Joint / Basal Thumb Joint Arthritis / Basilar Joint Arthritis / Carpometacarpal Arthritis / Trapeziometacarpal Arthritis1
4TerminatedTreatmentChronic Low Back Pain (CLBP)1
4TerminatedTreatmentDisseminated Sclerosis / Pain, Chronic / Pain, Neuropathic1
4TerminatedTreatmentFace Pain1
4TerminatedTreatmentForearm Fractures1
4TerminatedTreatmentHeart Diseases1
4TerminatedTreatmentKnee Osteoarthritis (Knee OA)1
4TerminatedTreatmentNasolabial Folds1
4TerminatedTreatmentPelvic Pain1
4TerminatedTreatmentPulmonary Arterial Hypertension (PAH)1
4TerminatedTreatmentShoulder Pain1
4TerminatedTreatmentTrigger Finger Disorder1
4Unknown StatusNot AvailableDependence, Cocaine1
4Unknown StatusNot AvailableEndophthalmitis / Vitreoretinal Surgery1
4Unknown StatusBasic ScienceColorectal Cancers1
4Unknown StatusPreventionDrug Usage1
4Unknown StatusPreventionGynecological Pathologies1
4Unknown StatusPreventionOral Hemorrhage1
4Unknown StatusSupportive CareInjection Site Irritation1
4Unknown StatusTreatmentCholecystolithiasis1
4Unknown StatusTreatmentDilatation and Evacuation / Laminaria Placement / Pain Alleviation1
4Unknown StatusTreatmentFractures of the Distal Radius1
4Unknown StatusTreatmentIUD Insertion Complication / Pain Control1
4Unknown StatusTreatmentInfraclavicular Brachial Plexus Block1
4Unknown StatusTreatmentPlanned Abdominal Hysterectomy1
4Unknown StatusTreatmentPostoperative Agitation of Patients1
4Unknown StatusTreatmentPostoperative pain4
4Unknown StatusTreatmentRetinal Detachment1
4Unknown StatusTreatmentSternotomy1
4Unknown StatusTreatmentAdjunct to general anesthesia therapy1
4WithdrawnNot AvailableAdjunct to general anesthesia therapy / Elderly / Surgeries Requiring A Minimum One Day Hospitalization1
4WithdrawnNot AvailableFeeling Anxious / Pain1
4WithdrawnTreatmentAbdominal Cutaneous Nerve Entrapment Syndrome / Chronic Abdominal Wall Pain1
4WithdrawnTreatmentBursitis1
4WithdrawnTreatmentCataract Surgery Anesthesia1
Not AvailableActive Not RecruitingNot AvailableAAT Deficiency / AATD / Alpha-1 Antitrypsin Deficiency / Fibrosis, Liver1
Not AvailableActive Not RecruitingSupportive CareBreastcancer / Phyllodes Breast Tumor1
Not AvailableActive Not RecruitingSupportive CarePain1
Not AvailableActive Not RecruitingTreatmentHeel Fat Pad Atrophy1
Not AvailableActive Not RecruitingTreatmentLow Back Pain (LBP) / Osteoarthritis Nos, of Sacroiliac Joint / Sprain of Sacroiliac Ligament1
Not AvailableActive Not RecruitingTreatmentNeedle Insertion and Injection Pain1
Not AvailableActive Not RecruitingTreatmentPost-Operative Pain1
Not AvailableActive Not RecruitingTreatmentRotator Cuff / Subacromial Impingement Syndrome1
Not AvailableActive Not RecruitingTreatmentHair removal therapy1
Not AvailableCompletedNot AvailableAcute Gouty Arthritis / Arthritis / Headaches / Migraines / Muscle Spasms / Radicular syndrome / Synovitis / Tendonitis1
Not AvailableCompletedNot AvailableAnaesthesia therapy1
Not AvailableCompletedNot AvailableArrythmias / Blood Electrolyte Balance / Coronary Artery Bypass Graft / Dexmedetomidine / Lidocaine / Myocardial Injury / Unstable Angina (UA)1
Not AvailableCompletedNot AvailableCancer, Breast1
Not AvailableCompletedNot AvailableEpilepsies1
Not AvailableCompletedNot AvailableFemoroacetabular Impingement1
Not AvailableCompletedNot AvailableHealthy Volunteers1
Not AvailableCompletedNot AvailableHemodynamic Response1
Not AvailableCompletedNot AvailableMethaemoglobinaemia1
Not AvailableCompletedNot AvailablePain2
Not AvailableCompletedNot AvailablePain, Neuropathic1
Not AvailableCompletedNot AvailableRhytidoplasty1
Not AvailableCompletedNot AvailableThyroid Cancers1
Not AvailableCompletedNot AvailableTrigger Finger1
Not AvailableCompletedBasic ScienceDepression1
Not AvailableCompletedBasic ScienceDiabetic Foot Proned Patients1
Not AvailableCompletedBasic ScienceUrethral Analgesia1
Not AvailableCompletedDiagnosticBronchopulmonary Diseases2
Not AvailableCompletedDiagnosticConscious Sedation Failure During Procedure1
Not AvailableCompletedDiagnosticPain1
Not AvailableCompletedDiagnosticPostoperative pain / Postoperative; Parotitis / Prophylaxis against postoperative nausea and vomiting / Vitreoretinal Surgery1
Not AvailableCompletedHealth Services ResearchObesity, Morbid1
Not AvailableCompletedOtherKnee Osteoarthritis (Knee OA)1
Not AvailableCompletedOtherPain1
Not AvailableCompletedOtherPain, Neuropathic1
Not AvailableCompletedPreventionAdult Disease1
Not AvailableCompletedPreventionAgitation States as Acute Reaction to Gross Stress1
Not AvailableCompletedPreventionAnaesthesia therapy1
Not AvailableCompletedPreventionAnaesthesia therapy / Coughing / Extubation1
Not AvailableCompletedPreventionBMI >30 kg/m2 / Pain1
Not AvailableCompletedPreventionCognitive Decline1
Not AvailableCompletedPreventionGallbladder disorders1
Not AvailableCompletedPreventionGeneral Surgery1
Not AvailableCompletedPreventionHuman Immunodeficiency Virus (HIV)1
Not AvailableCompletedPreventionIntrauterine Device / Pain1
Not AvailableCompletedPreventionMyoma of Uterus1
Not AvailableCompletedPreventionNeoplasm, Gastric1
Not AvailableCompletedPreventionOther Intraoperative Cardiac Functional Disturbances During Cardiac Surgery1
Not AvailableCompletedPreventionPain3
Not AvailableCompletedPreventionPancreatitis1
Not AvailableCompletedPreventionPharyngitis1
Not AvailableCompletedPreventionPostoperative pain2
Not AvailableCompletedPreventionThyroidectomy1
Not AvailableCompletedSupportive CareAdult Patients Undergoing Phacoemulsification With Topical Anesthesia1
Not AvailableCompletedSupportive CareCataracts1
Not AvailableCompletedSupportive CareColorectal Cancers1
Not AvailableCompletedSupportive CareInfertilities1
Not AvailableCompletedSupportive CareInflammatory Reaction / Postoperative pain1
Not AvailableCompletedSupportive CareLabour Pain1
Not AvailableCompletedSupportive CareNalbuphine as an Adjuvant to L. A in Peribulbar Block for Cataract Surgery1
Not AvailableCompletedSupportive CareOsteoarthritis (OA)1
Not AvailableCompletedSupportive CarePain6
Not AvailableCompletedSupportive CareParkinson's Disease (PD)1
Not AvailableCompletedSupportive CareTrigeminal Neuralgia (TN)1
Not AvailableCompletedTreatmentAdductor Canal Block / Anaesthesia therapy1
Not AvailableCompletedTreatmentAge-Related Macular Degeneration (AMD)1
Not AvailableCompletedTreatmentAge-Related Macular Degeneration (ARMD) / Central Retinal Vein Occlusion (CRVO) / Diabetic Macular Edema (DME)1
Not AvailableCompletedTreatmentAllergic Skin Reaction / Anxiety Disorders1
Not AvailableCompletedTreatmentAnaesthesia therapy2
Not AvailableCompletedTreatmentAnesthetics, Local / Blood Levels of Buffered vs Non-buffered Lidocaine1
Not AvailableCompletedTreatmentBirth Injuries / Laceration / Pain1
Not AvailableCompletedTreatmentCarpal Tunnel Syndrome (CTS)1
Not AvailableCompletedTreatmentContraception / Pain1
Not AvailableCompletedTreatmentDermal Pharmacokinetic Measurements / Dermatology/Skin - Other1
Not AvailableCompletedTreatmentDiverticulitis / Inflammatory Bowel Diseases (IBD) / Malignant Neoplasm of Colon1
Not AvailableCompletedTreatmentDrug Usage1
Not AvailableCompletedTreatmentElective Total or Subtotal Abdominal Hysterectomy1
Not AvailableCompletedTreatmentEndometriosis1
Not AvailableCompletedTreatmentErectile Dysfunction (ED)1
Not AvailableCompletedTreatmentFibromyalgia1
Not AvailableCompletedTreatmentFracture Bone / Pain1
Not AvailableCompletedTreatmentHepatectomy1
Not AvailableCompletedTreatmentJellyfish Stings1
Not AvailableCompletedTreatmentLaparoscopic Cholecystectomy1
Not AvailableCompletedTreatmentLateral Epicondylitis1
Not AvailableCompletedTreatmentLocal Anesthesia / Postoperative pain / Self-Perception1
Not AvailableCompletedTreatmentLow Back Pain (LBP)1
Not AvailableCompletedTreatmentLumbar Puncture / Topical Analgesia1
Not AvailableCompletedTreatmentMigraines1
Not AvailableCompletedTreatmentMigrainous Headache1
Not AvailableCompletedTreatmentNeed for Urethral Catheterization to Rule Out Urinary Tract Infection / Pediatric Presentation of Urinary Tract Infection1
Not AvailableCompletedTreatmentOpioid Consumption / Postoperative pain1
Not AvailableCompletedTreatmentPain14
Not AvailableCompletedTreatmentPain Control for Intrauterine Device Insertions1
Not AvailableCompletedTreatmentPain Intensity1
Not AvailableCompletedTreatmentPartial Thickness Rotator Cuff Tear / Subacromial Impingement Syndrome1
Not AvailableCompletedTreatmentPelvic Floor Disorders1
Not AvailableCompletedTreatmentPerioperative Chest Pain1
Not AvailableCompletedTreatmentPlantar fascial fibromatosis1
Not AvailableCompletedTreatmentPost Operative Pain1
Not AvailableCompletedTreatmentPostoperative pain3
Not AvailableCompletedTreatmentPregnancy Termination / Uterine Curettage1
Not AvailableCompletedTreatmentProstate Cancer1
Not AvailableCompletedTreatmentRenal Stones1
Not AvailableCompletedTreatmentRotator Cuff Disease1
Not AvailableCompletedTreatmentSacroiliitis1
Not AvailableCompletedTreatmentSpine Surgery1
Not AvailableCompletedTreatmentStrokes1
Not AvailableCompletedTreatmentVestibulodynia1
Not AvailableCompletedTreatmentMinor burns1
Not AvailableEnrolling by InvitationNot AvailableBrain Diseases / Cardiovascular Disease (CVD) / Central Nervous System Diseases / Cerebrovascular Disorders / Cerebrovascular Stroke / Ischemia, Brain / Nervous System Diseases / Strokes / Vascular Diseases1
Not AvailableEnrolling by InvitationBasic ScienceArm Injury1
Not AvailableNot Yet RecruitingBasic ScienceCapsaicin / Lidocaine / Pain, Neuropathic / Ultaviolet B Light Burn1
Not AvailableNot Yet RecruitingBasic ScienceChronic Low Back Pain (CLBP)1
Not AvailableNot Yet RecruitingOtherUpper Extremity Injury1
Not AvailableNot Yet RecruitingPreventionAirway Complication of Anesthesia1
Not AvailableNot Yet RecruitingPreventionAnaesthesia therapy / Spinal Puncture1
Not AvailableNot Yet RecruitingTreatmentBrachial Plexus Block / Shoulder Dislocation1
Not AvailableNot Yet RecruitingTreatmentCancer, Breast / Mastectomy / Post Operative Pain / Regional Anesthesia1
Not AvailableNot Yet RecruitingTreatmentPain1
Not AvailableNot Yet RecruitingTreatmentPain Management / Peripheral Nerve Blocks / Sedation therapy / Total Knee Arthroplasty (TKA)1
Not AvailableNot Yet RecruitingTreatmentSurgery, Cardiac1
Not AvailableRecruitingNot AvailablePain1
Not AvailableRecruitingBasic ScienceCowhage / Histamine / Itching / Serotonine / Thermal Stimulation1
Not AvailableRecruitingBasic SciencePain1
Not AvailableRecruitingDiagnosticDysuria / Hematuria / Recurrent Uti1
Not AvailableRecruitingDiagnosticNeuroma / Pain, Neuropathic1
Not AvailableRecruitingOtherAnesthesia; Reaction1
Not AvailableRecruitingOtherCircumcision / Postoperative pain / Regional Anesthesia1
Not AvailableRecruitingPreventionArterial Hypotension1
Not AvailableRecruitingPreventionContraception1
Not AvailableRecruitingPreventionMetal Staple Removal After Total Knee Replacement1
Not AvailableRecruitingPreventionNonvalvular Atrial Fibrillation1
Not AvailableRecruitingPreventionNulliparity1
Not AvailableRecruitingPreventionOculocardiac Reflex / Postoperative pain / Prophylaxis against postoperative nausea and vomiting / Vitreoretinal Surgery1
Not AvailableRecruitingSupportive CareAbdominal Cancer1
Not AvailableRecruitingSupportive CareChronic Renal Failure (CRF)1
Not AvailableRecruitingSupportive CareIntravenous Injections / Vaccination1
Not AvailableRecruitingSupportive CareInvasive Bladder Cancer1
Not AvailableRecruitingSupportive CareLumbar Radiculopathy Due to Spinal Nerve Compression1
Not AvailableRecruitingSupportive CareNasal Pack Removal1
Not AvailableRecruitingSupportive CareOpioid Consumption / Postoperative pain1
Not AvailableRecruitingSupportive CareOsteoarthritis (OA)1
Not AvailableRecruitingTreatmentAbdominal Pain (AP) / Gastro-esophageal Reflux Disease (GERD) / Swallowing Disorders1
Not AvailableRecruitingTreatmentAccessory Nerve Injuries / EMG: Repetitive Nerve Stimulation Abnormality / Neck Cancer / Recurrent Laryngeal Nerve Injuries / Thyroid Cancers1
Not AvailableRecruitingTreatmentAnaesthesia therapy / Surgery--Complications1
Not AvailableRecruitingTreatmentArthritis / Back Pain1
Not AvailableRecruitingTreatmentBMI >30 kg/m2 / Type 2 Diabetes Mellitus1
Not AvailableRecruitingTreatmentBariatric Surgery Candidate / Opioids Use / Postoperative pain / Prophylaxis against postoperative nausea and vomiting1
Not AvailableRecruitingTreatmentBiceps Tendonitis / Injections1
Not AvailableRecruitingTreatmentCarpal Tunnel Syndrome (CTS)1
Not AvailableRecruitingTreatmentDiabetes Mellitus (DM) / Pain / Peripheral Neuropathy1
Not AvailableRecruitingTreatmentHeart Failure, Unspecified2
Not AvailableRecruitingTreatmentIUD Insertion Complication1
Not AvailableRecruitingTreatmentInterstitial Cystitis / Painful Bladder Syndrome (PBS)1
Not AvailableRecruitingTreatmentPain1
Not AvailableRecruitingTreatmentPelvic Organ Prolapse (POP)1
Not AvailableRecruitingTreatmentPeripheral Solitary Pulmonary Nodule or Tuberculoma1
Not AvailableRecruitingTreatmentPilonidal Sinus1
Not AvailableRecruitingTreatmentThe Comparison of the I-gel and Endotracheal Tube About in Different Ventilation Settings During Laparoscopic Surgery1
Not AvailableSuspendedTreatmentPaediatric Flexible Bronchoscopy1
Not AvailableTerminatedBasic SciencePain1
Not AvailableTerminatedDiagnosticLabour Pain1
Not AvailableTerminatedPreventionGeneral Surgery / Pain / Pregnancy1
Not AvailableTerminatedPreventionIntubation; Difficult1
Not AvailableTerminatedPreventionLaryngospasm1
Not AvailableTerminatedTreatmentHysterectomy1
Not AvailableTerminatedTreatmentLaparoscopic Colorectal Resection1
Not AvailableTerminatedTreatmentLumbar Puncture / Meningitis / Pain1
Not AvailableTerminatedTreatmentLumbar and Other Intervertebral Disc Disorders With Radiculopathy1
Not AvailableTerminatedTreatmentMigraines1
Not AvailableTerminatedTreatmentNausea / Pain1
Not AvailableTerminatedTreatmentPain2
Not AvailableUnknown StatusNot AvailableCesarean Delivery / Pain1
Not AvailableUnknown StatusNot AvailablePlantar Warts1
Not AvailableUnknown StatusNot AvailableType 2 Diabetes Mellitus1
Not AvailableUnknown StatusBasic ScienceAnesthetics, Local1
Not AvailableUnknown StatusEducational/Counseling/TrainingPain1
Not AvailableUnknown StatusPreventionAsymptomatic Gallstones Without Cholecystitis / Gallbladder Polyps1
Not AvailableUnknown StatusPreventionContraception1
Not AvailableUnknown StatusPreventionThroat Pain1
Not AvailableUnknown StatusSupportive CareOverweight and Obesity1
Not AvailableUnknown StatusTreatmentInfertilities1
Not AvailableUnknown StatusTreatmentMacular Degeneration1
Not AvailableUnknown StatusTreatmentPain2
Not AvailableUnknown StatusTreatmentPain During and After Endovenous Laser Obliteration of Large Saphenous Vein Based on Lidocaine Tumescent Concentration1
Not AvailableUnknown StatusTreatmentPregnancy1
Not AvailableUnknown StatusTreatmentRenal Stones / Ureteral Calculus1
Not AvailableUnknown StatusTreatmentTuberculosis1
Not AvailableUnknown StatusTreatmentType 2 Diabetes Mellitus1
Not AvailableWithdrawnNot AvailableAirway Complication of Anaesthesia1
Not AvailableWithdrawnNot AvailablePain1
Not AvailableWithdrawnDiagnosticInterstitial Cystitis1
Not AvailableWithdrawnPreventionGeneral Surgery / Pain1
Not AvailableWithdrawnPreventionSpinal Puncture Complications1
Not AvailableWithdrawnSupportive CarePain1
Not AvailableWithdrawnTreatmentAdhesive Capsulitis1
Not AvailableWithdrawnTreatmentBack Pain1
Not AvailableWithdrawnTreatmentLabour / Pregnant State1
Not AvailableWithdrawnTreatmentNasolabial Folds Correction / Pain1
Not AvailableWithdrawnTreatmentPain1
Not AvailableWithdrawnTreatmentPlantar fascial fibromatosis1
Not AvailableWithdrawnTreatmentTotal Knee Arthroplasty (TKA)1

Pharmacoeconomics

Manufacturers
  • Astrazeneca lp
  • Noven pharmaceuticals inc
  • Carlisle laboratories inc
  • E fougera div altana inc
  • Graham chemical co
  • Taro pharmaceuticals usa inc
  • Teikoku pharma usa inc
  • Abbott laboratories pharmaceutical products div
  • Abbott laboratories hosp products div
  • Abraxis pharmaceutical products
  • Akorn inc
  • Baxter healthcare corp anesthesia and critical care
  • Bel mar laboratories inc
  • Dell laboratories inc
  • Elkins sinn div ah robins co inc
  • Gd searle llc
  • Hospira inc
  • International medication systems ltd
  • International medication system
  • Luitpold pharmaceuticals inc
  • Miles laboratories inc
  • Watson laboratories inc
  • Wyeth ayerst laboratories
  • Baxter healthcare corp
  • B braun medical inc
  • App pharmaceuticals llc
  • Meridian medical technologies inc
  • Dentsply pharmaceutical
  • Polymedica industries inc
  • Teva pharmaceuticals usa
  • Hi tech pharmacal co inc
  • Wockhardt eu operations (swiss) ag
  • Actavis mid atlantic llc
  • Vintage pharmaceuticals llc
  • Roxane laboratories inc
  • Kendall co
  • Paco research corp
  • Anesiva inc
Packagers
  • 4uOrtho LLC
  • A. Aarons Inc.
  • Actavis Group
  • Aerospace Accessory Service Inc.
  • Akorn Inc.
  • Amend
  • American Dental Cooperative Inc.
  • American Regent
  • Amphastar Pharmaceuticals
  • APP Pharmaceuticals
  • Aristos Pharmaceuticals
  • A-S Medication Solutions LLC
  • AstraZeneca Inc.
  • Ato Zizine Sarl
  • Auriga Pharmaceuticals LLC
  • Avent Inc.
  • B. Braun Melsungen AG
  • Baxter International Inc.
  • Benco Dental Co.
  • Blairex Labs
  • Bradley Pharmaceuticals Inc.
  • Breckenridge Pharmaceuticals
  • Brookstone Pharmaceuticals
  • C.O. Truxton Inc.
  • Cardent International Inc.
  • Cardinal Health
  • Carestream Health Inc.
  • Carlisle Laboratories Inc.
  • Catalent Pharma Solutions
  • Codman and Shurtleff Inc.
  • Covidien LP
  • Cypress Pharmaceutical Inc.
  • Darby Dental Supply Co. Inc.
  • Deltex Pharmaceuticals Inc.
  • DENTSPLY International
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • Doak Dermatologics
  • DSC Laboratories
  • E. Fougera and Co.
  • Eastman Kodak Co. Dental Products
  • Endo Pharmaceuticals Inc.
  • Enterprises Importfab Inc.
  • F Hoffmann-La Roche Ltd.
  • Fresca Gourmet Inc.
  • General Injectables and Vaccines Inc.
  • Groupe Parima Inc.
  • H Meer Dental Supply Co.
  • H.J. Harkins Co. Inc.
  • Henry Schein Inc.
  • Hi Tech Pharmacal Co. Inc.
  • Hospira Inc.
  • Innoviant Pharmacy Inc.
  • Keltman Pharmaceuticals Inc.
  • Kent Dental
  • Klosterfrau Berlin GmbH
  • Kylemore Pharmaceuticals
  • Laboratorios Zeyco SA De CV
  • Lake Erie Medical and Surgical Supply
  • Luitpold Pharmaceuticals Inc.
  • Major Pharmaceuticals
  • Marlop Pharmaceuticals Inc.
  • Martica Enterprises Inc.
  • Mckesson Corp.
  • Medical Components Inc.
  • Medical Techniques LLC
  • Merit Pharmaceuticals
  • National Pharmaceuticals
  • NeLLCor Puritan Bennett Mexico SA De CV
  • Nord Ost Corp.
  • Noven Pharmaceuticals Inc.
  • Novocol Pharmaceutical Canada
  • Nycomed Inc.
  • Odan Laboratories Ltd.
  • Palmetto Pharmaceuticals Inc.
  • Patterson Dental Supply Inc.
  • Pharmaderm
  • Pharmedium
  • Pharmedix
  • Physicians Total Care Inc.
  • Preferred Pharmaceuticals Inc.
  • Primedics Laboratories
  • Puretek Corp.
  • Qualitest
  • Raz Co. Inc.
  • Rebel Distributors Corp.
  • Rising Pharmaceuticals
  • River's Edge Pharmaceuticals
  • Roxane Labs
  • S&P Healthcare
  • Safco Dental Supply Co.
  • Sandoz
  • Septodont Inc.
  • Sheffield Laboratories Div Faria Limited LLC
  • Smiths Medical ASD Inc.
  • Sonar Products Inc.
  • Southwood Pharmaceuticals
  • Stat Rx Usa
  • Taro Pharmaceuticals USA
  • Tech Group Tempe
  • Teikoku Seiyaku Co. Ltd.
  • Teva Pharmaceutical Industries Ltd.
  • Tri State Hospital Supply Corp.
  • Veratex Corp.
  • Vintage Pharmaceuticals Inc.
  • Vyteris Inc.
  • Wallach Surgical Devices Inc.
  • Welch Allyn Inc.
  • Wockhardt Ltd.
Dosage forms
FormRouteStrength
SolutionIntravenous20 mg
KitTopical
LiquidSubarachnoid
PatchTopical246 mg/1
KitOral; Topical
GelTopical25 mg/mL
SolutionTopical1 %
Liquid; sprayTopical0.5 %
GelTopical0.5 %
GelTopical2.5 g/100g
GelOphthalmic35 mg/mL
GelTopical5 mg/mL
OintmentTopical4 g/100mL
SwabTopical4 g/100mL
GelTopical.5 g/100mL
GelTopical2.5 g/g
PatchTopical1 g/10g
LiquidInfiltration; Subcutaneous1 %
CreamTopical5 g/100mL
LiquidEpidural1 %
OintmentTopical.05 g/g
Kit; liquidIntravenous
LiquidIntravenous
LiquidIntra-articular1 %
PatchTopical411.4 mg/1
OintmentTopical246 mg/1
LotionTopical4 g/100g
PatchTopical422 mg/1
CreamTopical2 g/100g
ImplantIntradermal.3 %
GelTopical4.1 mg/mL
PatchTopical
GelTopical0.7 %
LiquidTopical2 %
CreamTopical2 %
GelTopical2 g/100g
CreamTopical2.8 g/56g
Aerosol, sprayTopical
CreamTopical40 mg/1
SprayTopical10 mg/mg
LiquidTopical3.4 g/68mL
SprayTopical20 mg/L
CreamTopical2.25 %
GelTopical2 g/100mL
GelTopical2.5 g/100mL
SprayTopical2 g/100mL
LotionTopical3 g/100g
CreamTopical3.9 g/100mL
GelTopical0.72 %
SprayTopical.05 g/100g
SprayTopical.5 g/100g
SprayTopical200 g/L
SprayTopical2.4 %
GelTopical5.05 g/g
GelTopical.025 g/g
CreamTopical10 mg/g
CreamTopical.04 mg/mg
GelTopical1.0 %
GelTopical20 mg
TabletDental
Liquid; ointmentIntravenous; Topical
Kit; liquid; ointmentInfiltration; Parenteral; Subcutaneous; Topical
LiquidEpidural; Infiltration; Subcutaneous
PatchTopical560 mg/1
CreamTopical4 g/100mL
CreamTopical40 mg/mL
GelTopical5 mg/g
RinseTopical
PatchTransdermal40 mg/1
SolutionIntra-articular; Intrabursal
SprayTopical50 mg/g
KitTopical
CreamTopical38.8 mg/g
CreamTopical1.2 g/30g
CreamTopical1.5 g/30g
CreamTopical5 g/100g
KitOral; Topical
KitBuccal; Topical
SprayTopical10 mg/.08mL
KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical
Kit
LotionTopical4 g/mL
SprayTopical10 mg/100mL
Kit; ointment; solutionInfiltration; Intravenous; Topical
CreamTopical20 mg/1000mg
SprayTopical40 mg/1000mg
CreamTopical50 mg/1000mg
GelTopical50 mg/1000mg
SprayTopical50 mg/1000mg
CreamTopical40 mg/1000mg
GelTopical40 mg/1000mg
LiquidTopical40 mg/1000mg
CreamTopical4 mg/mL
Liquid; sprayTopical
SwabTopical
SprayTopical
CreamTopical
SprayCutaneous
GelTopical10 mg/g
SprayTopical10 mg/mL
GelTopical2 %
KitIntra-amniotic
AerosolTopical40 mg/g
GelTopical500 g/100000mg
SprayCutaneous.5 g/100g
OintmentTopical4 g/100g
CreamTopical5.0 %
GelTopical.8 g/100g
GelTopical0.8 %
CreamTopical45 mg/mL
LiquidTopical
SoapTopical
SprayTopical40 mg/g
SoapTopical50 mg/g
Injection, solutionIntra-articular
Liquid; ointmentEpidural; Topical
LotionTopical.5 g/100mL
KitInfiltration; Intramuscular; Intravenous; Topical
GelTopical4 g/50g
LotionTopical
Spray, meteredTopical96 mg/mL
LiquidEndotracheal40 mg
SolutionTopical40 mg/mL
LotionTopical30 mg/mL
Aerosol, sprayTopical.64 g/127g
CreamTopical40 mg/g
CreamTopical50 mg/g
Injection, solutionInfiltration10 mg/mL
Injection, solutionSubcutaneous
OintmentTopical10 1/1
OintmentTopical2.5 g/50g
OintmentTopical35.44 g/g
OintmentTopical5 g/100g
OintmentTopical50 mg/g
PatchCutaneous140 mg/1
PatchTopical50 mg/g
SolutionInfiltration
CreamTopical.03 g/g
CreamTopical30 mg/g
Injection, solutionInfiltration20 mg/mL
CreamRectal
CreamRectal; Topical
GelRectal
SolutionIntravenous
LiquidEpidural; Infiltration10 mg
LiquidInfiltration10 mg
LiquidIntravenous20 mg
SolutionInfiltration10 mg
GelTopical30 mg/g
GelTopical40 mg/g
InjectionEpidural; Infiltration; Intracaudal10 mg/mL
InjectionInfiltration; Intravenous10 mg/mL
InjectionInfiltration; Intravenous20 mg/mL
InjectionInfiltration; Intravenous5 mg/mL
InjectionIntravenous20 mg/mL
InjectionParenteral20 mg/mL
Injection, solutionEpidural; Infiltration10 mg/mL
Injection, solutionEpidural; Infiltration20 mg/mL
Injection, solutionEpidural; Infiltration; Intracaudal10 mg/mL
Injection, solutionEpidural; Infiltration; Intracaudal20 mg/mL
Injection, solutionEpidural; Infiltration; Intracaudal; Perineural10 mg/mL
Injection, solutionEpidural; Infiltration; Intracaudal; Perineural20 mg/mL
Injection, solutionEpidural; Infiltration; Perineural20 mg/mL
Injection, solutionInfiltration; Intravenous5 mg/mL
Injection, solutionIntravenous10 mg/mL
Injection, solutionIntravenous20 mg/mL
Injection, solutionRetrobulbar; Topical40 mg/mL
JellyTopical20 mg/mL
LiquidTopical20 mg/mL
LiquidTopical200 mL/L
LotionTopical3 g/100mL
LotionTopical5.31 mL/177mL
SolutionOral20 mg/mL
SolutionOropharyngeal20 mg/mL
SolutionTopical20 mg/mL
SprayTopical20 g/L
SolutionEpidural; Infiltration
Injection, solutionIntraspinal
Injection, solutionIntravenous
Injection, solutionIntravenous4 mg/mL
Injection, solutionIntravenous400 mg/100mL
Injection, solutionIntravenous8 mg/mL
Injection, solutionIntravenous800 mg/100mL
InjectionInfiltration
Injection, solutionDental; Infiltration
Injection, solutionEpidural
Injection, solutionInfiltration
SolutionInfiltration5 mg
LiquidInfiltration2 %
SolutionInfiltration20 mg
SprayTopical1 %
GelOral2 g/100mL
SolutionInfiltration1 %
SolutionInfiltration2 %
OintmentTopical5 g
CreamTopical39.2 mg/mL
SolutionOral; Topical20 mg/mL
PatchTopical4 g/1
PatchTopical11 mg/1
SprayTopical20 mg/mL
GelTopical7.2 g/240g
SprayTopical4.6 g/115g
CreamTopical10 g/100g
SolutionTopical4 %
LiquidTopical10 mg
JellyTopical20 mg
JellyTopical2 %
OintmentTopical5 %
LiquidBuccal2 %
PatchCutaneous50 mg/g
PatchCutaneous700 mg/1
PatchCutaneous700 mg/12h
LiquidCutaneous700 mg/1000mg
GelTopical3 mg/100mL
PatchTopical22.7 mg/.24mg
PatchTopical25.3 mg/.24mg
PatchTopical25.8 mg/.24mg
PatchTopical28.1 mg/.24mg
PatchTopical29 mg/.24mg
PatchTopical21.5 mg/.24mg
LiquidAuricular (otic)
PatchTransdermal
CreamTopical32.5 mg/g
CreamTopical37.5 mg/g
CreamTopical39.5 mg/g
KitOral
LotionTopical30 mg/177mL
SprayTopical10 mg/.1mL
LiquidInfiltration
InjectionIntramuscular
GelTopical2.36 g/118mL
Spray, meteredTopical10 mg/100mL
LiquidSubcutaneous1 %
Spray, meteredTopical9.6 mg/100mL
KitEpidural; Infiltration; Topical
CreamTopical4 %
CreamTopical5 %
PatchTopical40 mg/1
AerosolTopical
KitOral
GelTopical.04 g/g
GelTopical10 mg/mL
Solution / dropsOphthalmic; Topical
KitEpidural; Infiltration; Intravenous
Liquid; ointmentSubcutaneous; Topical
LiquidInfiltration; Intraspinal; Subcutaneous1 %
CreamTopical.04 g/28g
SolutionIntramuscular; Intravenous
CreamTopical50 mg/mL
SprayTopical24.64 mg/mL
CreamTopical5 mg/g
CreamTopical5 mg/30g
SprayTopical.04 mg/mg
SolutionTopical
StickTopical
LiquidDental; Subcutaneous
LiquidSubcutaneous
GelPeriodontal
SuspensionAuricular (otic)
CreamTopical.04 g/40g
LotionTopical40 mg/4mL
LiquidTopical4 g/100mL
CreamTopical4 g/100g
PatchTopical.3 g/1
GelTopical7.128 mg/mL
GelTopical7.13 mg/mL
LiquidInfiltration; Subcutaneous; Topical
GelTopical2 mg/g
LiquidIntravenous1 %
Kit; ointment; solutionInfiltration; Subcutaneous; Topical
CreamTopical41.2 mg/g
Injection, solutionIntraocular; Ophthalmic
KitInfiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical
LiquidEpidural; Intravenous
LiquidDental2 %
Solution / dropsAuricular (otic)
SprayTopical2.6 %
SprayTopical4 %
SolutionTopical40 mg
CreamTopical400 mg/mg
OintmentTopical.005 mg/g
Spray, meteredTopical9.6 g/100mL
OintmentTopical10 mg/mL
SprayTopical10 g/100g
PatchTopical240 mg/1
PackingDental
PatchTopical18 mg/116cm2
KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular
KitEpidural; Infiltration; Intramuscular; Intravenous
KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue
KitEpidural; Infiltration
KitEpidural; Infiltration; Intra-articular; Intramuscular; Topical
CreamTopical.04 g/g
CreamTopical.05 g/g
ClothTopical
GelTopical1 g/100g
GelTopical20 mg/g
GelTopical20 mg/mL
LiquidTopical40 mg/mL
GelTopical4 g/100g
GelTopical4 %
SprayTopical2 %
SolutionTopical2 %
PatchPercutaneous; Topical; Transdermal560 mg/1
CreamPercutaneous; Topical; Transdermal
LiquidPercutaneous; Topical; Transdermal
SprayTopical1.1 g/12g
GelTopical2.0 %
GelTopical40 mg/mL
GelTopical1 %
SprayTopical5 mg/g
LotionTopical0.5 %
SprayTopical4 g/100mL
GelTopical.057 mg/mL
GelTopical0.50 %
CreamTopical.5 g/100g
KitInfiltration; Topical
LiquidParenteral; Topical
LiquidInfiltration; Subcutaneous
KitInfiltration1 %
SprayTopical96 mg/mL
Spray, meteredTopical9.6 %
GelTopical.5 g/100g
AerosolTopical0.5 %
SwabTopical1 %
PatchCutaneous
OintmentTopical
Kit
PatchTopical4 g/100g
LiquidIntrathoracic; Subcutaneous1 %
GelTopical2.36 g/59g
SprayTopical2.36 g/59g
GelTopical5 %
GelTopical5 g/100g
GelTopical15 mg/mL
GelTopical4 g/100mL
LiquidTopical50 mg/mL
SprayTopical2.5 g/100mL
GelTopical2.5 %
SprayTopical.5 mg/100mg
GelTopical
CreamTopical1 %
SolutionTopical0.5 %
SprayTopical0.5 %
CreamTopical2 g/mL
CreamTopical4 g/mL
InjectionInfiltration10 mg/mL
Injection, solutionInfiltration; Perineural
Injection, solutionInfiltration; Perineural10 mg/mL
Injection, solutionInfiltration; Perineural20 mg/mL
Injection, solutionInfiltration; Perineural5 mg/mL
JellyTopical.5 mg/18mL
LiquidIntraspinal
LiquidInfiltration5 mg
SolutionEpidural15 mg
LiquidInfiltration20 mg
SolutionEpidural20 mg
SolutionEpidural
LiquidSubarachnoid50 mg
SolutionEpidural; Infiltration17.3 mg
SolutionOral100 mg
Injection, solutionEpidural; Infiltration; Intracaudal; Perineural
Injection, solutionEpidural; Infiltration; Intracaudal; Perineural15 mg/mL
Injection, solutionInfiltration5 mg/mL
LiquidIntraspinal; Percutaneous1 %
LiquidPercutaneous1 %
LiquidEpidural
LiquidInfiltration1 %
AerosolOral; Topical
SprayTopical40 mg
LiquidTopical50 mg
LiquidOral; Topical20 mg
SolutionRetrobulbar; Topical40 mg/mL
LiquidEpidural; Intracaudal20 mg
SolutionIntravenous100 mg
LiquidIntravenous200 mg
Aerosol, metered; sprayTopical
Spray, meteredTopical
LiquidTopical2.5 %
SolutionTopical4.0 %
PowderIntradermal.5 mg/1
PatchTopical36 mg/1
Prices
Unit descriptionCostUnit
Rocephin 10 gm vial478.32USD each
Lidocaine HCl 3% Lotion 177ml Bottle230.3USD bottle
Rocephin 2 gm vial97.5USD each
Rocephin 1 gm vial62.02USD each
EMLA 2.5-2.5% Cream 30 gm Tube58.4USD tube
Lidocaine-Prilocaine 2.5-2.5% Cream 30 gm Tube47.79USD tube
Lidocaine HCl 2% Gel 10ml Syringe17.99USD syringe
Lidocaine HCl 2% Gel 30ml Tube17.99USD tube
Lidocaine HCl 4% Solution 50ml Bottle16.99USD bottle
Lidocaine Viscous 2% Solution 100ml Bottle13.99USD bottle
Lidocaine hcl 1% syringe9.76USD ml
Lidocaine HCl 4% Solution 4ml Bottle9.42USD bottle
Lidoderm 1 Box = 30 Patches8.03USD patch
Akten 3.5% drops7.5USD ml
Lidocaine 5% in d7.5w ampul3.06USD ml
Lidocaine 3% cream2.91USD g
Lidamantle 3% cream2.03USD g
Zilactin-l cold sore liquid0.99USD ml
Xylocaine 2% jelly0.68USD ml
Lidocaine hcl 10% vial0.55USD ml
Xylocaine 5% ointment0.42USD g
Xylocaine Jelly 2 % Jelly0.41USD g
Xylocaine 2% Solution0.34USD ml
Xylocaine 5 % Ointment0.29USD g
Lidocaine HCl 1% Solution0.24USD ml
Lidocaine hcl powder0.24USD g
Lidocaine base powder0.22USD g
Lidocaine hcl 4% solution0.18USD ml
Xylocaine 0.5% vial0.18USD ml
Lidodan 5 % Ointment0.16USD g
Xylocaine Viscous 2 % Liquid0.1USD ml
Lidocaine hcl 0.5% vial0.08USD ml
Solarcaine aerosol0.06USD g
Lidodan Viscous 2 % Liquid0.06USD ml
Lidocaine 2% viscous solution0.03USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5234957No1994-02-272011-02-27Us
US5827529No1995-10-272015-10-27Us
US8540665No2009-10-222029-10-22Us
US6881200No1996-06-112016-06-11Us
US6004286No1997-03-172017-03-17Us
US5899880No1996-05-042016-05-04Us
US6031007No1997-04-012017-04-01Us
US6629968No2000-06-302020-06-30Us
US6635045No2001-06-292021-06-29Us
US6546281No1995-07-282015-07-28Us
US5658583No1995-07-282015-07-28Us
US6465006No1995-07-282015-07-28Us
US6465709No2000-07-072020-07-07Us
US6780426No1995-07-282015-07-28Us
US6306431No1995-07-282015-07-28Us
US5919479No1995-07-282015-07-28Us
US6528086No1999-09-282019-09-28Us
US8759401No2006-07-242026-07-24Us
US9370622No2015-09-282035-09-28Us
US9358338No2015-04-272035-04-27Us
US9283174No2011-05-102031-05-10Us
US9925264No2011-05-102031-05-10Us
US9931403No2011-05-102031-05-10Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)68.5 °CPhysProp
boiling point (°C)159-160 °C at 2.00E+00 mm HgPhysProp
water solubility4100 mg/L (at 30 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP2.44AVDEEF,A (1997)
logS-1.76ADME Research, USCD
Caco2 permeability-4.21ADME Research, USCD
pKa8.01SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.593 mg/mLALOGPS
logP1.81ALOGPS
logP2.84ChemAxon
logS-2.6ALOGPS
pKa (Strongest Acidic)13.78ChemAxon
pKa (Strongest Basic)7.75ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area32.34 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity73.93 m3·mol-1ChemAxon
Polarizability27.77 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Download (7.18 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-000i-9000000000-38a47958df650b972703
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-000i-0090000000-7a90fe8d9b35b745cfce
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-001i-0920000000-f9f648594c0f1642cc4c
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0089-0900000000-5716ccc63e48696473bc
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9000000000-9d18ae1cd0a81ee63d35
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-0090000000-83bc5908a67b3ba4b826
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-8090000000-e305bfb01d615662d8a1
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9000000000-eab27554002663b2d3fd
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9000000000-1b684e31ff74300b808f
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9000000000-b39af34b526d79a4b07b
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9000000000-9466a1403df493f5b6e9
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-0090000000-c773b8e10c70518882c1
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-8090000000-00b6d0139ebe20cdb189
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9000000000-0b33ce49934844438e43
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9000000000-502494c9626d1dca25d1
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9000000000-b39af34b526d79a4b07b
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9000000000-86c007695ec40849f993
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9000000000-7f630b7fa4e36c59e0d2
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-000i-9060000000-b5aef137d8e488097fc4
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-000i-9000000000-b21ee69ce889ba36b5e5
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-000i-9000000000-9d7555c18e41a90508a5
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-000i-0090000000-3dd6e01da50ad1a66b2f
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-000i-9230000000-577ea8a290877187b518
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-000i-9000000000-3f33ed4d35a979dbd732
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-000i-9000000000-343e9e6a26be64016b15
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-000i-9000000000-c1923c77757d099538dd
LC-MS/MS Spectrum - LC-ESI-IT , positiveLC-MS/MSsplash10-000i-9000000000-9ff21e9bcf3f87f70774
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9000000000-eaebad6c7c4ce7832c9c
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9000000000-2e21612ecf5a40923bb5
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9050000000-930a3c8f94fdb363cc0f
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9000000000-bc7800eef651a1a0ee2c
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-000i-9000000000-a658a8aeac537602e1a7
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-000i-9000000000-5a056c9766b47a19f0a2
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-000i-9000000000-d649b0b05937216241a6
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-000i-6090000000-31a60a2cff302fde1ad8
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-000i-9020000000-da68f84a1fd4a905c98c
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as m-xylenes. These are aromatic compounds that contain a m-xylene moiety, which is a monocyclic benzene carrying exactly two methyl groups at the 1- and 3-positions.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Xylenes
Direct Parent
m-Xylenes
Alternative Parents
Trialkylamines / Propargyl-type 1,3-dipolar organic compounds / Carboximidic acids / Organopnictogen compounds / Organooxygen compounds / Hydrocarbon derivatives
Substituents
M-xylene / Tertiary aliphatic amine / Tertiary amine / Organic 1,3-dipolar compound / Propargyl-type 1,3-dipolar organic compound / Carboximidic acid derivative / Carboximidic acid / Organic nitrogen compound / Organic oxygen compound / Organopnictogen compound
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
tertiary amino compound, monocarboxylic acid amide, benzenes (CHEBI:6456)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Voltage-gated sodium channel activity
Specific Function
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference acro...
Gene Name
SCN10A
Uniprot ID
Q9Y5Y9
Uniprot Name
Sodium channel protein type 10 subunit alpha
Molecular Weight
220623.605 Da
References
  1. Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mould J, Drinkwater R, Baker MD, Abrahamsen B, Wood JN, Adams DJ, Christie MJ, Lewis RJ: muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):17030-5. Epub 2006 Oct 31. [PubMed:17077153]
  2. Muroi Y, Chanda B: Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol. 2009 Jan;133(1):1-15. doi: 10.1085/jgp.200810103. Epub 2008 Dec 15. [PubMed:19088384]
  3. Karoly R, Lenkey N, Juhasz AO, Vizi ES, Mike A: Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. PLoS Comput Biol. 2010 Jun 17;6(6):e1000818. doi: 10.1371/journal.pcbi.1000818. [PubMed:20585544]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Voltage-gated sodium channel activity
Specific Function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a...
Gene Name
SCN9A
Uniprot ID
Q15858
Uniprot Name
Sodium channel protein type 9 subunit alpha
Molecular Weight
226370.175 Da
References
  1. Sheets PL, Jackson JO 2nd, Waxman SG, Dib-Hajj SD, Cummins TR: A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity. J Physiol. 2007 Jun 15;581(Pt 3):1019-31. Epub 2007 Apr 12. [PubMed:17430993]
  2. Muroi Y, Chanda B: Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol. 2009 Jan;133(1):1-15. doi: 10.1085/jgp.200810103. Epub 2008 Dec 15. [PubMed:19088384]
  3. Karoly R, Lenkey N, Juhasz AO, Vizi ES, Mike A: Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. PLoS Comput Biol. 2010 Jun 17;6(6):e1000818. doi: 10.1371/journal.pcbi.1000818. [PubMed:20585544]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Voltage-gated sodium channel activity involved in sa node cell action potential
Specific Function
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the pr...
Gene Name
SCN5A
Uniprot ID
Q14524
Uniprot Name
Sodium channel protein type 5 subunit alpha
Molecular Weight
226937.475 Da
References
  1. Itoh H, Tsuji K, Sakaguchi T, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Ashihara T, Ito M, Horie M, Imoto K: A paradoxical effect of lidocaine for the N406S mutation of SCN5A associated with Brugada syndrome. Int J Cardiol. 2007 Oct 18;121(3):239-48. Epub 2007 Apr 18. [PubMed:17445919]
  2. Fedida D, Orth PM, Hesketh JC, Ezrin AM: The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers. J Cardiovasc Electrophysiol. 2006 May;17 Suppl 1:S71-S78. [PubMed:16686685]
  3. Wallace CH, Baczko I, Jones L, Fercho M, Light PE: Inhibition of cardiac voltage-gated sodium channels by grape polyphenols. Br J Pharmacol. 2006 Nov;149(6):657-65. Epub 2006 Oct 3. [PubMed:17016511]
  4. Cerne A, Bergh C, Borg K, Ek I, Gejervall AL, Hillensjo T, Olofsson JI, Stener-Victorin E, Wood M, Westlander G: Pre-ovarian block versus paracervical block for oocyte retrieval. Hum Reprod. 2006 Nov;21(11):2916-21. Epub 2006 Jul 13. [PubMed:16840798]
  5. Muroi Y, Chanda B: Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol. 2009 Jan;133(1):1-15. doi: 10.1085/jgp.200810103. Epub 2008 Dec 15. [PubMed:19088384]
  6. Karoly R, Lenkey N, Juhasz AO, Vizi ES, Mike A: Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. PLoS Comput Biol. 2010 Jun 17;6(6):e1000818. doi: 10.1371/journal.pcbi.1000818. [PubMed:20585544]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Ubiquitin protein ligase binding
Specific Function
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TG...
Gene Name
EGFR
Uniprot ID
P00533
Uniprot Name
Epidermal growth factor receptor
Molecular Weight
134276.185 Da
References
  1. Sakaguchi M, Kuroda Y, Hirose M: The antiproliferative effect of lidocaine on human tongue cancer cells with inhibition of the activity of epidermal growth factor receptor. Anesth Analg. 2006 Apr;102(4):1103-7. [PubMed:16551906]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Voltage-gated sodium channel activity
Specific Function
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the pr...
Gene Name
SCN4A
Uniprot ID
P35499
Uniprot Name
Sodium channel protein type 4 subunit alpha
Molecular Weight
208059.175 Da
References
  1. Leuwer M, Haeseler G, Hecker H, Bufler J, Dengler R, Aronson JK: An improved model for the binding of lidocaine and structurally related local anaesthetics to fast-inactivated voltage-operated sodium channels, showing evidence of cooperativity. Br J Pharmacol. 2004 Jan;141(1):47-54. Epub 2003 Dec 8. [PubMed:14662728]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in...
Gene Name
ORM1
Uniprot ID
P02763
Uniprot Name
Alpha-1-acid glycoprotein 1
Molecular Weight
23511.38 Da
References
  1. Herve F, Duche JC, d'Athis P, Marche C, Barre J, Tillement JP: Binding of disopyramide, methadone, dipyridamole, chlorpromazine, lignocaine and progesterone to the two main genetic variants of human alpha 1-acid glycoprotein: evidence for drug-binding differences between the variants and for the presence of two separate drug-binding sites on alpha 1-acid glycoprotein. Pharmacogenetics. 1996 Oct;6(5):403-15. [PubMed:8946472]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and ava...
Gene Name
ORM2
Uniprot ID
P19652
Uniprot Name
Alpha-1-acid glycoprotein 2
Molecular Weight
23602.43 Da
References
  1. Herve F, Duche JC, d'Athis P, Marche C, Barre J, Tillement JP: Binding of disopyramide, methadone, dipyridamole, chlorpromazine, lignocaine and progesterone to the two main genetic variants of human alpha 1-acid glycoprotein: evidence for drug-binding differences between the variants and for the presence of two separate drug-binding sites on alpha 1-acid glycoprotein. Pharmacogenetics. 1996 Oct;6(5):403-15. [PubMed:8946472]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT: Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65. [PubMed:10901707]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. [PubMed:19754423]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  3. Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT: Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65. [PubMed:10901707]
  4. Wei X, Dai R, Zhai S, Thummel KE, Friedman FK, Vestal RE: Inhibition of human liver cytochrome P-450 1A2 by the class IB antiarrhythmics mexiletine, lidocaine, and tocainide. J Pharmacol Exp Ther. 1999 May;289(2):853-8. [PubMed:10215663]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C18
Uniprot ID
P33260
Uniprot Name
Cytochrome P450 2C18
Molecular Weight
55710.075 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Const...
Gene Name
CYP2A6
Uniprot ID
P11509
Uniprot Name
Cytochrome P450 2A6
Molecular Weight
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Symporter activity
Specific Function
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cat...
Gene Name
SLC22A5
Uniprot ID
O76082
Uniprot Name
Solute carrier family 22 member 5
Molecular Weight
62751.08 Da
References
  1. Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. [PubMed:11160873]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol. 2001 Dec;14(12):1596-603. [PubMed:11743742]
  2. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103]
  3. Hu Y, Qin X, Cao H, Yu S, Feng J: Reversal effects of local anesthetics on P-glycoprotein-mediated cancer multidrug resistance. Anticancer Drugs. 2017 Mar;28(3):243-249. doi: 10.1097/CAD.0000000000000455. [PubMed:27906699]

Drug created on June 13, 2005 07:24 / Updated on August 14, 2018 07:18