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Identification
NameLidocaine
Accession NumberDB00281  (APRD00479, DB05291)
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionA local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine. [PubChem]
Structure
Thumb
Synonyms
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
alpha-diethylamino-2,6-dimethylacetanilide
Lignocaine
α-diethylamino-2,6-dimethylacetanilide
External Identifiers
  • LSM-3165
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
2% Lidocaine Hydrochloride Injection USPSolution20 mgIntravenousHospira Healthcare Corporation1987-12-31Not applicableCanada
AgoneazeKitTopicalAlvix Laboratories, LLC2016-01-12Not applicableUs
AktenGel35 mg/mLOphthalmicAkorn, Inc.2008-10-08Not applicableUs
Amniocentesis Tray 1%Liquid1 %Infiltration; SubcutaneousAllegiance Healthcare Corporation1992-12-312000-07-31Canada
AnestheticGel5 g/100gTopicalCosmoceutical Research Center Inc2012-02-18Not applicableUs
Antecubital Cent Venous Catheterization KitLiquid1 %EpiduralArrow International Inc.1991-12-311999-07-02Canada
Arthrogram Tray 1%Liquid1 %Intra-articularAllegiance Healthcare Corporation1992-12-312000-07-31Canada
Atelocollagen ImplantImplant.3 %IntradermalKoken Co. Ltd.1989-12-312005-08-25Canada
Basic Biopsy Tray 1%Liquid1 %Infiltration; SubcutaneousAllegiance Healthcare Corporation1992-12-312000-07-31Canada
Bio-scriptives Lidum Topical AnalgesicCream2.8 g/56gTopicalBio Scriptives, Inc.2012-03-07Not applicableUs
Burncare SpraySpray2.4 %TopicalAvacare, Division Of Jeunique International Inc.1985-12-311997-11-10Canada
CathejellGel20 mgTopicalPharmazeutische Fabrik Montavit Ges M.B.H.2012-05-25Not applicableCanada
Derma NumbSpray40 mg/gTopicalAtlas Tat Inc.2012-07-15Not applicableUs
Laryng O Jet KitLiquid40 mgEndotrachealInternational Medication Systems Ltd.1978-12-311997-08-15Canada
LidocaineInjection, solution20 mg/mLIntravenousCardinal Health2000-09-05Not applicableUs
LidocainePatch700 mg/1CutaneousQualitest Pharmaceuticals2014-05-02Not applicableUs
LidocainePatch700 mg/1CutaneousLake Erie Medical DBA Quality Care Products LLC2014-05-02Not applicableUs
LidocainePatch700 mg/1CutaneousDIRECT RX2016-03-03Not applicableUs
LidocaineInjection, solution20 mg/mLIntravenousAPP Pharmaceuticals, LLC2000-09-05Not applicableUs
LidocainePatch700 mg/1CutaneousCardinal Health2014-05-02Not applicableUs
LidocainePatch700 mg/1CutaneousPreferred Pharmaceuticals Inc.2016-08-16Not applicableUs
Lidocaine HCl Inj 1%Liquid10 mgEpidural; InfiltrationInternational Medication Systems Ltd.1971-12-311997-08-15Canada
Lidocaine HCl Inj 10mg/ml USPLiquid10 mgInfiltrationElkins Sinn Inc.1995-12-312004-02-16Canada
Lidocaine HCl Inj 20mg/mlLiquid20 mgIntravenousInternational Medication Systems Ltd.1982-12-311997-08-15Canada
Lidocaine HCl InjectionSolution20 mgInfiltrationAlveda Pharmaceuticals Inc2015-08-19Not applicableCanada
Lidocaine HCl InjectionSolution10 mgInfiltrationAlveda Pharmaceuticals Inc2015-06-29Not applicableCanada
Lidocaine HCl Injection USP 1% (50 Mg/5ml)Solution10 mgInfiltration4410602 Canada IncNot applicableNot applicableCanada
Lidocaine HCl Injection USP 1% (50mg/5ml)Solution10 mgInfiltrationValesco Pharmaceuticals Inc2010-11-17Not applicableCanada
Lidocaine HCl Injection With PreservativeSolution10 mgInfiltrationAlveda Pharmaceuticals Inc2015-11-25Not applicableCanada
Lidocaine HCl Injection With PreservativeSolution20 mgInfiltrationAlveda Pharmaceuticals Inc2016-01-12Not applicableCanada
Lidocaine HCl Jelly 2%Jelly20 mgTopicalInternational Medication Systems Ltd.1971-12-311997-08-15Canada
Lidocaine HydrochlorideGel40 mg/gTopicalLake Erie Medical DBA Quality Care Products LLC2016-05-01Not applicableUs
Lidocaine HydrochlorideGel40 mg/gTopicalGensco Laboratories, LLC2016-05-01Not applicableUs
Lidocaine HydrochlorideGel40 mg/gTopicalGensco Laboratories, LLC2009-06-30Not applicableUs
Lidocaine Hydrochloride and DextroseInjection, solution4 mg/mLIntravenousBaxter Healthcare Corporation1981-04-22Not applicableUs
Lidocaine Hydrochloride and DextroseInjection, solution8 mg/mLIntravenousBaxter Healthcare Corporation1981-04-22Not applicableUs
Lidocaine Hydrochloride and DextroseInjection, solution400 mg/100mLIntravenousHospira, Inc.1980-12-192016-03-03Us
Lidocaine Hydrochloride and DextroseInjection, solution800 mg/100mLIntravenousHospira, Inc.1980-12-192016-03-03Us
Lidocaine Hydrochloride InjectionSolution10 mgInfiltrationSterimax IncNot applicableNot applicableCanada
Lidocaine Hydrochloride Injection USPSolution10 mgInfiltrationMylan Pharmaceuticals Ulc1994-12-31Not applicableCanada
Lidocaine Hydrochloride Injection USPLiquid20 mgInfiltrationMylan Pharmaceuticals Ulc1994-12-31Not applicableCanada
Lidocaine Hydrochloride Injection USP 0.5%Solution5 mgInfiltrationHospira Healthcare CorporationNot applicableNot applicableCanada
Lidocaine Hydrochloride Injection USP 1%Solution10 mgInfiltrationHospira Healthcare Corporation1990-12-31Not applicableCanada
Lidocaine Hydrochloride Injection USP 2%Solution20 mgInfiltrationHospira Healthcare Corporation1994-12-31Not applicableCanada
Lidocaine Hydrochloride Injection USP 2%Liquid2 %InfiltrationAlveda Pharmaceuticals Inc2009-01-09Not applicableCanada
Lidocaine Hydrochloride Injection, USP 1%Solution10 mgInfiltrationAlveda Pharmaceuticals Inc2008-04-23Not applicableCanada
Lidocaine Ont 5% Graham FlavoredOintment5 gTopicalGraham Chemical Corp.1986-10-311999-08-10Canada
Lidodan 4% Topical SolutionSolution4 %TopicalOdan Laboratories Ltd2014-02-20Not applicableCanada
Lidodan Endotracheal Non-aerosol SprayLiquid10 mgTopicalOdan Laboratories Ltd1998-07-22Not applicableCanada
Lidodan Jelly 2%(single Use Syringe)Jelly2 %TopicalOdan Laboratories Ltd2002-06-01Not applicableCanada
Lidodan Ointment 5%Ointment5 %TopicalOdan Laboratories Ltd1994-12-31Not applicableCanada
LidodermPatch700 mg/12hCutaneousRebel Distributors Corp.2010-02-01Not applicableUs
LidodermPatch700 mg/1Cutaneousbryant ranch prepack1999-03-20Not applicableUs
LidodermPatch700 mg/1CutaneousSTAT Rx USA LLC2010-02-01Not applicableUs
LidodermPatch700 mg/1CutaneousH.J. Harkins Company, Inc.1999-03-20Not applicableUs
LidodermPatch700 mg/1CutaneousLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-01Not applicableUs
LidodermPatch700 mg/1CutaneousSTAT Rx USA LLC1999-03-20Not applicableUs
LidodermPatch700 mg/1CutaneousPhysicians Total Care, Inc.2003-05-05Not applicableUs
LidodermPatch700 mg/1CutaneousAidarex Pharmaceuticals LLC1999-03-20Not applicableUs
LidodermPatch700 mg/1CutaneousDispensing Solutions, Inc.1999-03-20Not applicableUs
LidodermPatch700 mg/1CutaneousUnit Dose Services1999-03-20Not applicableUs
LidodermPatch700 mg/1CutaneousEndo Pharmaceuticals Inc.1999-03-20Not applicableUs
Lidoderm 5Liquid700 mg/1000mgCutaneousSt Marys Medical Park Pharmacy2010-12-21Not applicableUs
Lumbar Puncture Tray 1%Liquid1 %Infiltration; SubcutaneousAllegiance Healthcare Corporation1992-12-312000-07-31Canada
Lumbar Puncture Tray 1% Pediatric/infantLiquid1 %SubcutaneousAllegiance Healthcare Corporation1992-12-312000-07-31Canada
Myelogram Tray 1%Liquid1 %Infiltration; Intraspinal; SubcutaneousAllegiance Healthcare Corporation1992-12-312000-07-31Canada
Percutaneous Sheath Introducer Kit Hl-09883Liquid1 %IntravenousArrow International Inc.1989-12-311999-07-02Canada
Preattached Lta KitSolution40 mgTopicalHospira Healthcare Corporation1979-12-312016-02-25Canada
Spinal Anesthesia Tray 1%Kit1 %InfiltrationBaxter Corporation1994-12-312001-07-31Canada
Thoracentesis Tray 1%Liquid1 %Intrathoracic; SubcutaneousAllegiance Healthcare Corporation1992-12-312000-07-31Canada
XylocaineInjection, solution10 mg/mLInfiltration; PerineuralGeneral Injectables & Vaccines, Inc2011-09-26Not applicableUs
XylocaineInjection, solution10 mg/mLInfiltrationREMEDYREPACK INC.2015-05-18Not applicableUs
XylocaineInjection, solution10 mg/mLInfiltration; PerineuralCardinal Health2010-08-12Not applicableUs
XylocaineJelly20 mg/mLTopicalCardinal Health2012-07-16Not applicableUs
XylocaineInjection, solution20 mg/mLInfiltration; PerineuralPhysicians Total Care, Inc.1993-11-09Not applicableUs
XylocaineInjection, solution10 mg/mLInfiltration; PerineuralFresenius Kabi USA, LLC2010-08-12Not applicableUs
XylocaineInjection10 mg/mLInfiltrationRebel Distributors Corp1948-11-19Not applicableUs
XylocaineInjection, solution20 mg/mLInfiltration; PerineuralCardinal Health2010-08-12Not applicableUs
XylocaineSolution40 mg/mLTopicalAPP Pharmaceuticals, LLC2009-11-11Not applicableUs
XylocaineInjection, solution20 mg/mLInfiltration; PerineuralFresenius Kabi USA, LLC2010-08-12Not applicableUs
XylocaineJelly20 mg/mLTopicalAPP Pharmaceuticals, LLC2010-09-27Not applicableUs
XylocaineInjection, solution20 mg/mLIntravenousAPP Pharmaceuticals, LLC2009-11-11Not applicableUs
XylocaineInjection, solution10 mg/mLInfiltration; PerineuralCardinal Health2010-08-12Not applicableUs
XylocaineInjection, solution20 mg/mLInfiltration; PerineuralREMEDYREPACK INC.2016-06-07Not applicableUs
XylocaineInjection, solution20 mg/mLInfiltration; PerineuralGeneral Injectables & Vaccines, Inc2011-11-09Not applicableUs
XylocaineInjection, solution20 mg/mLInfiltration; PerineuralCardinal Health2010-08-12Not applicableUs
XylocaineInjection, solution10 mg/mLInfiltration; PerineuralPhysicians Total Care, Inc.1995-05-15Not applicableUs
XylocaineInjection, solution5 mg/mLInfiltration; PerineuralFresenius Kabi USA, LLC2010-08-12Not applicableUs
XylocaineJelly.5 mg/18mLTopicalOak Pharmaceuticals, Inc. (Subsidiary of Akorn, Inc.)2012-07-01Not applicableUs
XylocaineInjection, solution5 mg/mLInfiltration; PerineuralGeneral Injectables & Vaccines, Inc2011-09-21Not applicableUs
Xylocaine 0.5%Solution5 mgInfiltrationAstrazeneca Canada Inc2012-10-29Not applicableCanada
Xylocaine 0.5%Liquid5 mgInfiltrationAstrazeneca Canada Inc1954-12-312015-05-31Canada
Xylocaine 1.5%Solution15 mgEpiduralAstrazeneca Canada Inc1954-12-312005-08-02Canada
Xylocaine 1%Liquid10 mgInfiltrationAstrazeneca Canada Inc1954-12-31Not applicableCanada
Xylocaine 1%Liquid10 mgInfiltrationAstrazeneca Canada Inc2009-01-23Not applicableCanada
Xylocaine 2%Liquid20 mgInfiltrationAstrazeneca Canada Inc1997-03-192003-07-24Canada
Xylocaine 2%Liquid20 mgInfiltrationAstrazeneca Canada Inc1954-12-31Not applicableCanada
Xylocaine 2%Liquid20 mgInfiltrationAstrazeneca Canada Inc2009-01-29Not applicableCanada
Xylocaine 2% EpiduralSolution20 mgEpiduralAstrazeneca Canada Inc1965-12-312005-08-02Canada
Xylocaine 2% JellyJelly20 mgUrethralAstrazeneca Canada Inc1978-12-31Not applicableCanada
Xylocaine 5% SpinalLiquid50 mgSubarachnoidAstrazeneca Canada Inc1984-12-312002-10-18Canada
Xylocaine Co2 InjSolution17.3 mgEpidural; InfiltrationAstrazeneca Canada Inc1973-12-312004-09-01Canada
Xylocaine EndotrachealSolution100 mgOralAstrazeneca Canada Inc1993-12-31Not applicableCanada
Xylocaine Jelly 2%Jelly20 mgTopicalAstrazeneca Canada Inc1951-12-31Not applicableCanada
Xylocaine MpfInjection, solution5 mg/mLInfiltrationFresenius Kabi USA, LLC2010-08-12Not applicableUs
Xylocaine MpfInjection, solution20 mg/mLEpidural; Infiltration; Intracaudal; PerineuralFresenius Kabi USA, LLC2011-07-18Not applicableUs
Xylocaine MpfInjection, solution20 mg/mLEpidural; Infiltration; Intracaudal; PerineuralCardinal Health2010-08-12Not applicableUs
Xylocaine MpfInjection, solution10 mg/mLEpidural; Infiltration; Intracaudal; PerineuralFresenius Kabi USA, LLC2010-08-12Not applicableUs
Xylocaine MpfInjection, solution10 mg/mLEpidural; Infiltration; Intracaudal; PerineuralCardinal Health2010-08-12Not applicableUs
Xylocaine MpfInjection, solution15 mg/mLEpidural; Infiltration; Intracaudal; PerineuralFresenius Kabi USA, LLC2011-07-18Not applicableUs
Xylocaine MpfInjection, solution20 mg/mLEpidural; Infiltration; Intracaudal; PerineuralCardinal Health2010-08-12Not applicableUs
Xylocaine MpfLiquid1 %PercutaneousAstra Pharmaceuticals L.P.Not applicableNot applicableCanada
Xylocaine MpfInjection, solution20 mg/mLEpidural; Infiltration; Intracaudal; PerineuralFresenius Kabi USA, LLC2010-08-12Not applicableUs
Xylocaine MpfInjection, solution10 mg/mLEpidural; Infiltration; Intracaudal; PerineuralCardinal Health2010-08-12Not applicableUs
Xylocaine Mpf 1%Liquid1 %InfiltrationAstrazeneca L.P.1988-12-312001-10-12Canada
Xylocaine Ointment 5%Ointment5 %TopicalAstrazeneca Canada Inc1954-12-31Not applicableCanada
Xylocaine Topical 4%Spray40 mgTopicalAstrazeneca Canada Inc1962-12-312015-04-30Canada
Xylocaine Topical 5%Liquid50 mgTopicalAstrazeneca Canada Inc1958-12-312003-01-24Canada
Xylocaine Viscous 2%Liquid20 mgOral; TopicalAstrazeneca Canada Inc1954-12-31Not applicableCanada
Xylocaine-mpfSolution40 mg/mLRetrobulbar; TopicalAPP Pharmaceuticals, LLC2009-11-11Not applicableUs
Xylocaine-mpf, 2%Liquid20 mgEpidural; IntracaudalAstra Pharmaceuticals L.P.Not applicableNot applicableCanada
Xylocard InjLiquid100 mgIntravenousAstrazeneca Canada Inc1974-12-31Not applicableCanada
Xylocard One Gm Additive Unit 20% InjLiquid200 mgIntravenousAstra Pharma Inc.1974-12-311999-07-29Canada
ZingoPowder.5 mg/1Intradermal7 T Pharma Llc2016-06-01Not applicableUs
ZingoPowder.5 mg/1IntradermalMedline Industries, Inc.2014-02-212017-05-31Us
ZingoPowder.5 mg/1IntradermalPowder Pharmaceuticals Inc.2015-01-05Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AccucaineInjection, solution10 mg/mLInfiltrationAsclemed Usa, Inc.1972-09-28Not applicableUs
AnestaconJelly20 mg/mLTopicalHi Tech Pharmacal Co., Inc.2001-11-05Not applicableUs
Dermacinrx Lido V PakKitTopicalPure Tek Corporation2016-09-22Not applicableUs
Dermacinrx Phn PakKitPure Tek Corporation2016-05-17Not applicableUs
Dx1 Oragenomic Medicated Dna Collection ScreenKitIt3 Medical Llc2016-05-01Not applicableUs
Dx2 Oragenomic Medicated Dna Collection ScreenKitIt3 Medical Llc2016-05-01Not applicableUs
GlydoJelly20 mg/mLTopicalSagent Pharmaceuticals2014-09-15Not applicableUs
Laryng-O-jetSolution40 mg/mLTopicalAmphastar Pharmaceuticals, Inc.1980-03-06Not applicableUs
LidocaineOintment5 g/100gTopicalLake Erie Medical DBA Quality Care Products LLC2012-03-12Not applicableUs
LidocaineJelly20 mg/mLTopicalA S Medication Solutions2015-06-15Not applicableUs
LidocaineOintment50 mg/gTopicalLake Erie Medical DBA Quality Care Products LLC2013-03-25Not applicableUs
LidocaineOintment50 mg/gTopicalAv Kare, Inc.2015-09-21Not applicableUs
LidocaineOintment50 mg/gTopicalPharmaceutica North America, Inc.2016-05-06Not applicableUs
LidocaineOintment50 mg/gTopicalPreferred Pharmaceuticals Inc.2016-08-23Not applicableUs
LidocainePatch700 mg/1CutaneousA S Medication Solutions2013-09-15Not applicableUs
LidocainePatch700 mg/1CutaneousLake Erie Medical DBA Quality Care Products LLC2013-09-15Not applicableUs
LidocaineJelly20 mg/mLTopicalAkorn, Inc.2003-08-01Not applicableUs
LidocaineOintment50 mg/gTopicalAmneal Pharmaceuticals of New York, LLC2015-08-10Not applicableUs
LidocaineOintment50 mg/gTopicalPreferred Pharmaceuticals Inc.2016-10-10Not applicableUs
LidocainePatch700 mg/1CutaneousActavis Pharma, Inc.2014-06-26Not applicableUs
LidocaineInjection, solution10 mg/mLInfiltrationREMEDYREPACK INC.2015-06-22Not applicableUs
LidocaineJelly20 mg/mLTopicalAidarex Pharmaceuticals LLC2015-06-15Not applicableUs
LidocainePatch700 mg/1CutaneousPure Tek Corporation2016-02-29Not applicableUs
LidocaineJelly20 mg/mLTopicalA S Medication Solutions2003-08-01Not applicableUs
LidocainePatch140 mg/1CutaneousMylan Pharmaceuticals Inc.2015-08-07Not applicableUs
LidocaineInjection, solution20 mg/mLEpidural; InfiltrationGeneral Injectables & Vaccines, Inc2010-04-01Not applicableUs
LidocaineInjection, solution10 mg/mLInfiltration; PerineuralAPP Pharmaceuticals, LLC2010-05-27Not applicableUs
LidocaineOintment50 mg/gTopicalPharmaceutica North America, Inc2015-08-13Not applicableUs
LidocaineOintment35.44 g/gTopicalSolubiomix2016-01-28Not applicableUs
LidocaineOintment50 mg/gTopicalSterling Knight Pharmaceuticals, Llc2016-08-15Not applicableUs
LidocaineOintment5 g/100gTopicalHi Tech Pharmacal Co., Inc.2012-03-12Not applicableUs
LidocaineOintment50 mg/gTopicalAidarex Pharmaceuticals LLC2016-02-01Not applicableUs
LidocaineOintment5 g/100gTopicalNovocol Inc.2011-10-01Not applicableUs
LidocaineJelly20 mg/mLTopicalAkorn, Inc.2013-08-01Not applicableUs
LidocaineJelly20 mg/mLTopicalActavis Pharma, Inc.2015-06-15Not applicableUs
LidocaineOintment50 mg/gTopicalPreferred Pharmaceuticals Inc.2016-06-28Not applicableUs
LidocainePatch700 mg/1CutaneousActavis Pharma, Inc.2013-09-15Not applicableUs
LidocaineJelly20 mg/mLTopicalPhysicians Total Care, Inc.2000-06-01Not applicableUs
LidocaineInjection, solution10 mg/mLInfiltration; PerineuralUs Med Source, Llc2014-07-02Not applicableUs
LidocaineOintment50 mg/gTopicalGemini Laboratories, Inc.2016-03-11Not applicableUs
LidocaineOintment50 mg/gTopicalTaro Pharmaceuticals U.S.A., Inc.1981-08-17Not applicableUs
LidocaineOintment50 mg/gTopicalIpg Pharmaceuticals, Inc.2016-11-15Not applicableUs
LidocaineInjection, solution20 mg/mLInfiltration; PerineuralAPP Pharmaceuticals, LLC2010-05-27Not applicableUs
LidocainePatch700 mg/1CutaneousDIRECT RX2014-01-01Not applicableUs
LidocaineOintment50 mg/gTopicalTeligent Pharma, Inc.2016-02-01Not applicableUs
LidocainePatch700 mg/1CutaneousClinical Solutions Wholesale2013-09-15Not applicableUs
LidocaineOintment50 mg/gTopicalPreferred Pharmaceuticals Inc.2016-06-28Not applicableUs
LidocaineOintment50 mg/gTopicalPreferred Pharmaceuticals Inc.2016-10-17Not applicableUs
LidocaineOintment50 mg/gTopicalTaro Pharmaceuticals U.S.A., Inc.2013-03-25Not applicableUs
LidocaineOintment50 mg/gTopicalAidarex Pharmaceuticals LLC1972-06-30Not applicableUs
LidocainePatch700 mg/1CutaneousCardinal Health2013-09-15Not applicableUs
LidocainePatch700 mg/1Cutaneousbryant ranch prepack2013-09-15Not applicableUs
LidocaineOintment50 mg/gTopicalGlenmark Pharmaceuticals Inc., Usa2016-09-09Not applicableUs
LidocaineOintment5 g/100gTopicalUnit Dose Services2012-03-12Not applicableUs
LidocaineJelly20 mg/mLTopicalAidarex Pharmaceuticals LLC2015-06-15Not applicableUs
LidocaineOintment50 mg/gTopicalRebel Distributors Corp1972-06-30Not applicableUs
LidocaineOintment5 g/100gTopicalSeptodont, Inc.2015-05-20Not applicableUs
LidocainePatch700 mg/1CutaneousUnit Dose Services2013-09-15Not applicableUs
LidocaineJelly20 mg/mLTopicalAkorn, Inc.2003-08-01Not applicableUs
LidocaineInjection, solution10 mg/mLInfiltration; PerineuralCardinal Health2010-05-27Not applicableUs
LidocaineOintment50 mg/gTopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1972-06-30Not applicableUs
LidocaineOintment50 mg/gTopicalAv Kare, Inc.2016-09-27Not applicableUs
LidocainePatch700 mg/1CutaneousPreferred Pharmaceuticals Inc.2016-06-29Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalAmphastar Pharmaceuticals, Inc.1979-08-07Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOropharyngealREMEDYREPACK INC.2013-06-10Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLInfiltrationGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLEpidural; Infiltration; Intracaudal; PerineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalCardinal Health1979-08-07Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLInfiltrationUs Med Source, Llc2014-06-12Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOral; TopicalPreferred Pharmaceuticals, Inc.2012-04-30Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLEpidural; InfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLEpidural; Infiltration; Intracaudal; PerineuralHospira, Inc.1984-05-17Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLEpidural; Infiltration; Intracaudal; PerineuralHospira, Inc.2005-09-07Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalHi Tech Pharmacal Co., Inc.2011-03-23Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLIntravenousHospira, Inc.1972-10-31Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLInfiltrationA S Medication Solutions Llc2010-03-30Not applicableUs
Lidocaine HydrochlorideInjection, solution40 mg/mLRetrobulbar; TopicalCardinal Health2010-03-24Not applicableUs
Lidocaine HydrochlorideSolution40 mg/mLTopicalInternational Medication Systems, Limited2012-06-19Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLEpidural; Infiltration; Intracaudal; PerineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLInfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLIntravenousMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-05-03Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLInfiltrationREMEDYREPACK INC.2013-09-27Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalInternational Medication Systems, Limited1979-08-07Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLInfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine HydrochlorideInjection, solution15 mg/mLEpidural; Infiltration; Intracaudal; PerineuralHospira, Inc.1972-09-28Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLEpidural; Infiltration; Intracaudal; PerineuralCardinal Health2010-03-30Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLInfiltrationGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLInfiltrationPhysicians Total Care, Inc.1994-06-28Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLEpidural; InfiltrationCardinal Health2009-11-17Not applicableUs
Lidocaine HydrochlorideSolution40 mg/mLTopicalMorton Grove Pharmaceuticals, Inc.1982-11-18Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOralLLC Federal Solutions2013-06-24Not applicableUs
Lidocaine HydrochlorideInjection5 mg/mLInfiltration; IntravenousMylan Institutional LLC2010-10-01Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLInfiltration; PerineuralHospira, Inc.1984-07-31Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOropharyngealQualitest Pharmaceuticals2007-02-272017-05-18Us
Lidocaine HydrochlorideSolution20 mg/mLOropharyngealUnit Dose Services2007-02-27Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLInfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLEpidural; Infiltration; Intracaudal; PerineuralHospira, Inc.1984-05-16Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalAmphastar Pharmaceuticals, Inc.1979-08-07Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLIntravenousREMEDYREPACK INC.2013-07-16Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLInfiltrationGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLEpidural; Infiltration; Intracaudal; PerineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalCardinal Health1979-08-07Not applicableUs
Lidocaine HydrochlorideInjection10 mg/mLInfiltration; IntravenousMylan Institutional LLC2010-09-12Not applicableUs
Lidocaine HydrochlorideInjection, solution15 mg/mLEpidural; Infiltration; Intracaudal; PerineuralHospira, Inc.1972-09-28Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOral; TopicalA S Medication Solutions1995-07-10Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLIntravenousHospira, Inc.1972-10-31Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalGeneral Injectables & Vaccines, Inc2012-06-12Not applicableUs
Lidocaine HydrochlorideSolution40 mg/mLTopicalA S Medication Solutions Llc2007-02-27Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLIntravenousCardinal Health2010-11-29Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLEpidural; Infiltration; Intracaudal; PerineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLInfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLInfiltrationMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-05-03Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOral; TopicalLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1995-07-10Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalInternational Medication Systems, Limited1979-08-07Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOral; TopicalCardinal Health1995-07-10Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLInfiltration; PerineuralCardinal Health2010-03-30Not applicableUs
Lidocaine HydrochlorideSolution40 mg/mLTopicalIGI Labs, Inc.2014-03-18Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLEpidural; Infiltration; Intracaudal; PerineuralA S Medication Solutions2005-09-07Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLIntravenousGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLIntravenousGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalCardinal Health1979-08-07Not applicableUs
Lidocaine HydrochlorideInjection10 mg/mLEpidural; Infiltration; IntracaudalMylan Institutional LLC2010-10-01Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLInfiltration; PerineuralHospira, Inc.1984-07-31Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOropharyngealA S Medication Solutions2007-02-27Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalAmphastar Pharmaceuticals, Inc.1979-08-07Not applicableUs
Lidocaine HydrochlorideSolution40 mg/mLTopicalQualitest Pharmaceuticals2007-02-272017-06-30Us
Lidocaine HydrochlorideInjection, solution10 mg/mLInfiltrationREMEDYREPACK INC.2013-06-12Not applicableUs
Lidocaine HydrochlorideInjection20 mg/mLInfiltration; IntravenousAGILA SPECIALTIES PRIVATE LIMITED2014-04-12Not applicableUs
Lidocaine HydrochlorideInjection, solution5 mg/mLInfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine HydrochlorideInjection, solution40 mg/mLRetrobulbar; TopicalHospira, Inc.1984-05-16Not applicableUs
Lidocaine HydrochlorideInjection20 mg/mLParenteralAmphastar Pharmaceuticals, Inc.2001-06-01Not applicableUs
Lidocaine HydrochlorideSolution40 mg/mLTopicalREMEDYREPACK INC.2013-09-25Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLEpidural; InfiltrationGeneral Injectables & Vaccines2010-04-01Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLEpidural; Infiltration; Intracaudal; PerineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine HydrochlorideInjection, solution40 mg/mLRetrobulbar; TopicalCardinal Health2010-03-24Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLIntravenousCardinal Health2010-11-29Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOropharyngealClinical Solutions Wholesale2007-02-27Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOral; TopicalRebel Distributors Corp1995-07-10Not applicableUs
Lidocaine HydrochlorideInjection10 mg/mLInfiltration; IntravenousMylan Institutional LLC2010-09-12Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLEpidural; Infiltration; Intracaudal; PerineuralHospira, Inc.1984-05-17Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLInfiltration; PerineuralA S Medication Solutions2005-07-12Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOral; TopicalUnit Dose Services1995-07-10Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLIntravenousHospira, Inc.1998-09-28Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalGeneral Injectables & Vaccines, Inc2012-05-30Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOral; TopicalPhysicians Total Care, Inc.2003-05-08Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLIntravenousA S Medication Solutions2005-12-01Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLIntravenousGeneral Injectables & Vaccine, Inc2010-03-01Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLEpidural; Infiltration; Intracaudal; PerineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLInfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLInfiltrationMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-05-03Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalInternational Medication Systems, Limited1979-08-07Not applicableUs
Lidocaine HydrochlorideSolution40 mg/mLTopicalWest Ward Pharmaceuticals Corp1985-04-03Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOral; TopicalSTAT RX LLC USA1995-07-10Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLInfiltration; PerineuralCardinal Health2010-03-30Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalAmphastar Pharmaceuticals, Inc.1979-08-07Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOropharyngealDIRECT RX2014-01-01Not applicableUs
Lidocaine HydrochlorideInjection, solution5 mg/mLInfiltrationGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLEpidural; Infiltration; Intracaudal; PerineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalCardinal Health1979-08-07Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLInfiltrationUs Med Source, Llc2014-05-29Not applicableUs
Lidocaine HydrochlorideInjection5 mg/mLInfiltration; IntravenousMylan Institutional LLC2010-09-12Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLInfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine HydrochlorideInjection, solution5 mg/mLInfiltration; IntravenousHospira, Inc.1984-05-17Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLEpidural; Infiltration; Intracaudal; PerineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLIntravenousREMEDYREPACK INC.2013-06-122016-11-08Us
Lidocaine HydrochlorideJelly20 mg/mLTopicalInternational Medication Systems, Limited1979-08-07Not applicableUs
Lidocaine HydrochlorideInjection, solution5 mg/mLInfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLEpidural; Infiltration; Intracaudal; PerineuralHospira, Inc.1972-09-28Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLInfiltrationREMEDYREPACK INC.2013-11-01Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLIntravenousGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLInfiltrationPhysicians Total Care, Inc.1994-08-23Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLIntravenousCardinal Health2010-11-29Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLTopicalMorton Grove Pharmaceuticals, Inc.1982-11-18Not applicableUs
Lidocaine HydrochlorideInjection10 mg/mLInfiltration; IntravenousMylan Institutional LLC2010-09-12Not applicableUs
Lidocaine HydrochlorideInjection, solution5 mg/mLInfiltration; PerineuralHospira, Inc.1984-07-31Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLInfiltration; PerineuralA S Medication Solutions2005-06-15Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalGeneral Injectables & Vaccines, Inc2012-08-28Not applicableUs
Lidocaine HydrochlorideInjection, solution20 mg/mLIntravenousHospira, Inc.1998-09-28Not applicableUs
Lidocaine HydrochlorideJelly20 mg/mLTopicalGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOral; TopicalAtlantic Biologicals Corps1995-07-10Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOropharyngealA S Medication Solutions Llc2007-02-27Not applicableUs
Lidocaine HydrochlorideInjection, solution10 mg/mLInfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOropharyngealMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2007-02-27Not applicableUs
Lidocaine HydrochlorideSolution20 mg/mLOral; TopicalHi Tech Pharmacal Co., Inc.1995-07-10Not applicableUs
Lidocaine HydrochlorideInjection20 mg/mLIntravenousInternational Medication Systems, Limited2001-06-01Not applicableUs
Lidocaine ViscousSolution20 mg/mLOral; TopicalRoxane Laboratories,Inc1985-04-26Not applicableUs
Lidocaine ViscousSolution20 mg/mLOral; TopicalDIRECT RX2014-01-01Not applicableUs
Lidocaine ViscousSolution20 mg/mLOral; TopicalRoxane Laboratories,Inc1985-04-26Not applicableUs
Lidocaine ViscousSolution20 mg/mLOral; TopicalRoxane Laboratories,Inc1985-04-26Not applicableUs
Lidocaine ViscousSolution20 mg/mLOral; TopicalCardinal Health1985-04-26Not applicableUs
Lidotrans 5 PakKitTopicalShoreline Pharmaceuticals, Inc.2016-09-16Not applicableUs
Medicated Dna Collection KitSolution20 mg/mLOral; TopicalTrue Fit Rx Llc2015-12-04Not applicableUs
Readysharp LidocaineInjection, solution10 mg/mLEpidural; Infiltration; Intracaudal; PerineuralTerrain Pharmaceuticals2005-07-08Not applicableUs
Sx1 Medicated Post-operative SystemKitIt3 Medical Llc2016-05-01Not applicableUs
Venipuncture Px1KitIt3 Medical Llc2016-05-01Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
After BurnGel25 mg/mLTopicalTender Corporation2011-04-12Not applicableUs
After Sun Burn Relief Lidocaine Continuous SpraySolution1 %TopicalPrime Enterprises Inc2010-04-08Not applicableCanada
After Sun GelGel1 %TopicalWatkins IncorporatedNot applicableNot applicableCanada
After Sun Soothing SprayLiquid; Spray0.5 %TopicalKinesys Pharmaceutical Inc1995-03-17Not applicableCanada
AfterburnGel2.5 g/100gTopicalTender Corporation2011-04-122016-11-03Us
AfterburnGel0.5 %TopicalTender Corporation1995-12-31Not applicableCanada
Aftersun Cooling CvsGel.5 g/100mLTopicalCVS2014-11-11Not applicableUs
AlocaneGel4 %TopicalQuest Products IncNot applicableNot applicableCanada
AlocaneOintment4 g/100mLTopicalQuest Products, Inc.2013-06-01Not applicableUs
AloeGel.5 g/100mLTopicalKmart Corporation2012-01-15Not applicableUs
Aloe Gel Pain Reliever Well At WalgreensGel.5 g/100gTopicalWalgreens2013-03-15Not applicableUs
Aloe Ice Sunburn Relief JellyGel2 g/100mLTopicalAloe Care International, Llc2014-02-24Not applicableUs
Aloe Ice Sunburn Relief JellyGel2 %TopicalAloe Care International LlcNot applicableNot applicableCanada
Aloe Vera GelGel2.5 g/gTopicalMeijer Distribution2016-08-29Not applicableUs
AnecreamCream4 %TopicalFocus Health GroupNot applicableNot applicableCanada
AnecreamCream4 g/100gTopicalFocus Health Group2007-06-01Not applicableUs
Anecream 5Cream5 g/100gTopicalFocus Health Group2011-12-20Not applicableUs
AnestaCream5 g/100gTopicalHumex,Inc.2016-01-01Not applicableUs
AnestaCream5 g/100gTopicalHumex,Inc.2016-01-01Not applicableUs
Anorectal EquateCream5 g/100mLTopicalWalmart2016-04-16Not applicableUs
AspercremePatch246 mg/1TopicalLead Chemical Co. Ltd.2016-02-16Not applicableUs
Aspercreme With LidocaineOintment246 mg/1TopicalChattem, Inc.2016-02-01Not applicableUs
Aspercreme With Lidocaine Pain Relieving CremeLotion4 g/100gTopicalChattem, Inc.2014-12-01Not applicableUs
AssuredGel2.5 g/100gTopicalAnhui Nhu Pharmaceutical Co., Ltd.2015-12-26Not applicableUs
AssuredGel2.5 g/100gTopicalZhejiang Jingwei Pharmaceutical Co., Ltd.2014-10-30Not applicableUs
AssuredGel2.5 g/100gTopicalAnhui Nhu Pharmaceutical Co., Ltd.2015-01-28Not applicableUs
Assured Bikini Smooth CreamCream2 g/100gTopicalZhejiang Jingwei Pharmaceutical Co., Ltd.2015-10-30Not applicableUs
Australian Gold Aloe Freeze Gel With LidocaineGel4.1 mg/mLTopicalPrime Enterprises, Inc.2014-06-09Not applicableUs
Banana Boat Soothacaine Spray GelGel0.7 %TopicalPlaytex Ltd.2005-02-152009-08-06Canada
Band-aid Brand Antiseptic WashLiquid2 %TopicalJohnson & Johnson Inc2002-03-01Not applicableCanada
Bed Bug Instant Bite ReliefGel40 mg/gTopicalP.F. Harris Mfg. Co. Llc2016-02-04Not applicableUs
Betacaine GelGel5 %TopicalProllenium Medical Technologies Inc2002-12-17Not applicableCanada
Bikini ReliefGel2 %TopicalAlexandria International Inc.2000-02-152006-06-26Canada
Bikini ZoneCream2 %TopicalCCA Industries, Inc.1997-10-30Not applicableCanada
Bikini Zone MedicatedGel2 g/100gTopicalCCA Industries, Inc.2010-06-04Not applicableUs
Bikini Zone Medicated CremeCream2 g/100gTopicalCCA Industries, Inc.2010-06-04Not applicableUs
Bikini Zone Medicated CremeCream2 g/100gTopicalCCA Industries, Inc.2010-06-03Not applicableUs
Bikini Zone Topical Analgesic GelGel2 %TopicalCCA Industries, Inc.Not applicableNot applicableCanada
Bio-scriptives LidumCream2.8 g/56gTopicalBio Chemics, Inc2010-07-23Not applicableUs
Bio-scriptives Lidum Hemorroidal (anorectal)Cream2.8 g/56gTopicalBio Scriptives, Inc.2012-03-04Not applicableUs
Blt 2Ointment4 g/100gTopicalCentura Pharmaceuticals Inc2016-11-21Not applicableUs
BonadurSpray10 mg/mgTopicalWeb Rx Pharmacy Palace2015-07-24Not applicableUs
BurnSpray20 mg/LTopicalAcme United Corp2014-10-06Not applicableUs
BurnSpray20 g/LTopicalFirst Aid Only, Inc2014-08-13Not applicableUs
Burn CreamCream2.25 %TopicalWatkins Incorporated2000-02-022013-08-02Canada
Burn JelGel2 g/100mLTopicalWater Jel Technologies2010-04-17Not applicableUs
Burn Jel 20 mg/gJelly20 mgTopicalWater Jel Technologies,Llc1992-12-311997-07-03Canada
Burn Jel PlusGel2.5 g/100mLTopicalWater Jel Technologies2010-04-10Not applicableUs
Burn MistSpray2 g/100mLTopicalWater Jel Technologies2010-05-17Not applicableUs
Burn Relief Gel With LidocaineGel0.72 %TopicalPrime Enterprises Inc2005-06-15Not applicableCanada
Burn Relief LeaderSpray.05 g/100gTopicalCardinal Health2011-12-01Not applicableUs
Burn Relief Pain Reliever Well At WalgreensSpray.5 g/100gTopicalWalgreens2013-03-15Not applicableUs
Burn Reliefpreferred Plus Ph Preferred Plus PharmacyGel.5 g/100mLTopicalKinray Inc.2013-03-15Not applicableUs
Burn With AloeSpray200 g/LTopicalProvision Medical2014-08-29Not applicableUs
Bz Step Pain Relief CreamCream.04 mg/mgTopicalBusiness Avenue, Llc2016-03-25Not applicableUs
Caribbean Breeze Burn ReliefGel1.0 %TopicalCaribbean Breeze International Inc.2007-07-25Not applicableCanada
Cbd Clinic - Mild Pain TherapyCream4 g/100gTopicalAidance Skincare & Topical Solutions, LLC2015-07-16Not applicableUs
ComfortcaineGel40 mg/gTopicalQS Key West Aloe, LLC2004-11-12Not applicableUs
Comfortox LidocaineCream40 mg/1000mgTopicalSambria Pharmaceuticals2016-09-14Not applicableUs
CuracaineCream4 g/100mLTopicalTransdermal Corp2015-03-03Not applicableUs
CuracaineCream4 g/100mLTopicalTransdermal Corp2012-09-12Not applicableUs
Curacaine Transdermal CorporationCream40 mg/mLTopicalTransdermal Corp2012-09-12Not applicableUs
CutiecaineCream50 mg/gTopicalTransdermal Corp2011-11-15Not applicableUs
CutiecaineCream4 %TopicalInnovatech IncNot applicableNot applicableCanada
CutiecaineCream40 mg/gTopicalInnovatech Inc2010-05-31Not applicableUs
Cutiecaine-5%Cream5 %TopicalInnovatech IncNot applicableNot applicableCanada
Cvs Burn Relief W/lido 8ozGel.5 g/100gTopicalCVS Pharmacy2015-07-08Not applicableUs
Derma Gel ReliefGel0.5 %TopicalJamp Pharma CorporationNot applicableNot applicableCanada
Derma NumbSpray50 mg/gTopicalAtlas Tat Inc.2014-08-06Not applicableUs
Dermanumb Tattoo AnestheticGel40 mg/gTopicalA.t.s. Laboratories, Llc2015-07-01Not applicableUs
Dermanumb Tattoo Anesthetic GelGel40 mg/gTopicalA.t.s. Laboratories, Llc2015-07-01Not applicableUs
Desert Harvest ReleveumCream40 mg/mLTopicalDesert Harvest Inc.2014-07-30Not applicableUs
Dr. NumbCream5 g/100gTopicalEi Inc.2012-11-15Not applicableUs
Dr. NumbCream5 %TopicalShinpharma Inc2013-10-08Not applicableCanada
Dr. NumbCream5 g/30gTopicalShinpharma Inc2016-07-01Not applicableUs
Dr. Richs NumbingGel4 g/100gTopicalGen Z Online Llc2014-08-27Not applicableUs
Dynamo DelaySpray10 mg/.08mLTopicalMomentum Management2015-05-13Not applicableUs
Ebsl-5KitWater Jel Technologies2014-06-11Not applicableUs
Ebss-5KitWater Jel Technologies2014-06-11Not applicableUs
Eclipse Topical AnestheticCream40 mg/mLTopicalSambria Pharmaceuticals, Inc.2015-04-112017-06-12Us
Eclipse Topical AnestheticCream40 mg/gTopicalSambria Pharmaceuticals2015-08-20Not applicableUs
Endurance Rx Male DesensitizerSpray10 mg/100mLTopicalM.D. Science Lab, Llc2015-06-09Not applicableUs
Endure Male Genital DesensitizingSpray10 mg/100mLTopicalEndure Holdings, Llc2015-02-18Not applicableUs
Exchange Select Burn Relief Pain RelievingGel.5 g/100gTopicalArmy and Air Force Exchange Service2012-11-15Not applicableUs
Exsel AloeGel.5 g/100gTopicalArmy and Air Force Exchange Service2013-08-06Not applicableUs
Extra Strength AftertatCream20 mg/1000mgTopicalRidge Properties2015-09-07Not applicableUs
Extra Strength PretatGel40 mg/1000mgTopicalRidge Properties2016-08-17Not applicableUs
Extra Strength PretatCream40 mg/1000mgTopicalRidge Properties2015-06-08Not applicableUs
Extra Strength PretatLiquid40 mg/1000mgTopicalRidge Properties2015-06-08Not applicableUs
Extra Strength PretatGel40 mg/1000mgTopicalRidge Properties2016-08-17Not applicableUs
Ez Pain RelievingCream4 mg/mLTopicalE2 Brokers Inc.2013-11-062015-12-29Us
Fruit Of The Earth Aloe Vera Cool BlueGel10 mg/gTopicalFruit Of The Earth, Inc.2014-09-10Not applicableUs
Fruit Of The Earth Cool Blue Aloe Mist ContinuousSpray10 mg/mLTopicalFruit Of The Earth, Inc.2014-09-12Not applicableUs
Fsk-5KitWater Jel Technologies2014-06-11Not applicableUs
Gardeners Skin Remedy Topical Analgesic GelGel2 %TopicalCrabtree & Evelyn Ltd.1998-03-272003-07-18Canada
General NumbGel5 g/100gTopicalEsba Laboratories Inc.2015-05-01Not applicableUs
Gigi Anesthetic NumbingAerosol40 mg/gTopical220 LABORATORIES INC1997-10-27Not applicableUs
Gold Bond Medicated Pain and Itch ReliefCream4 g/100gTopicalChattem, Inc.2016-01-15Not applicableUs
Good Neighbor Pharmacy Aloe VeraGel500 g/100000mgTopicalAMERISOURCEBERGEN DRUG CORPORATION1988-11-28Not applicableUs
Good Neighbor Pharmacy Burn Relief Aloe ExtraSpray.5 g/100gCutaneousAmerisource Bergen Drug Corporation2011-10-28Not applicableUs
H-releve HemorrhoidalCream4 g/100gTopicalPure Source Inc.2013-08-152016-01-07Us
H2ocean Nothing Tattoo Glide and Soothing BalmOintment4 g/100gTopicalAidance Skincare & Topical Solutions, LLC2015-06-29Not applicableUs
Harmony Numbing CreamCream5.0 %TopicalAgrisan Specialty Chemical & PharmaceuticalNot applicableNot applicableCanada
Hawaiian TropicGel.8 g/100gTopicalEnergizer Personal Care LLC2010-09-28Not applicableUs
Hawaiian Tropic After Sun Après Soleil Sunburn Relief Soulagement Des Coups De SoleilGel0.8 %TopicalEnergizer Canada Inc2010-02-152015-08-14Canada
Hem-easy Relief Herbal HemorrhoidalCream45 mg/mLTopicalBatool Pharma International, Inc2014-08-20Not applicableUs
Hush AnestheticSpray40 mg/gTopicalHUSH Anesthetic2012-12-01Not applicableUs
Hush AnestheticGel40 mg/gTopicalHUSH Anesthetic2012-12-01Not applicableUs
I.C.E. Lidocaine Gel - Gel LidocaineGel0.5 %TopicalEnergizer Canada Inc2004-10-282012-07-12Canada
Instant Burn Relief Aloe Extra CvsSpray.5 g/100gTopicalCVS2014-11-11Not applicableUs
Instant Cool Skin Instant Relief. Sudden ResultsLotion.5 g/100mLTopicalTherapon Skin Health, LP2015-06-15Not applicableUs
Iwk-5KitWater Jel Technologies2014-06-12Not applicableUs
Jampocaine 2% Viscous SolutionSolution2 %TopicalJamp Pharma Corporation2014-09-29Not applicableCanada
Jampocaine 5%Ointment5 %TopicalJamp Pharma Corporation2014-05-14Not applicableCanada
Kroger Burn Relief AloeGel.5 g/100gTopicalThe Kroger Co2012-11-19Not applicableUs
Ky Duration for MenSpray, metered96 mg/mLTopicalReckitt Benckiser LLC2016-09-01Not applicableUs
LidocaineCream40 mg/gTopicalCounty Line Pharmaceuticals, LLC2014-09-02Not applicableUs
LidocaineCream50 mg/gTopicalCounty Line Pharamceuticals2015-09-14Not applicableUs
LidocaineAerosol, spray.64 g/127gTopicalPremier Brands of America Inc.2013-01-01Not applicableUs
LidocaineAerosol, spray.64 g/127gTopicalChain Drug Consortium, LLC2005-12-07Not applicableUs
LidocaineCream4 g/100gTopicalPd Rx Pharmaceuticals, Inc.2011-10-01Not applicableUs
LidocaineAerosol, spray.64 g/127gTopicalTopco Associates LLC2012-01-03Not applicableUs
Lidocaine 4%Cream4 g/100gTopicalAlexso Inc2016-03-01Not applicableUs
Lidocaine 4% CreamCream4 g/100gTopicalCutis Health, LLC2014-12-01Not applicableUs
Lidocaine 5%Cream5 g/100gTopicalTri Marc Labs2011-10-01Not applicableUs
Lidocaine HydrochlorideSpray20 g/LTopicalCintas First Aid & Safety2013-04-18Not applicableUs
Lidocaine HydrochlorideLiquid20 mg/mLTopicalSafetec of America, Inc.2011-08-02Not applicableUs
Lidocaine HydrochlorideLiquid200 mL/LTopicalAfassco Inc.2012-02-16Not applicableUs
Lidocaine HydrochlorideGel20 mg/gTopicalAcme United Corporation2013-02-14Not applicableUs
Lidocaine HydrochlorideSpray20 g/LTopicalUnifirst First Aid Corporation2015-06-10Not applicableUs
Lidocaine HydrochlorideGel20 mg/gTopicalSafetec of America, Inc.2012-09-19Not applicableUs
Lidocaine Hydrochloride SolutionSpray1 %TopicalPrime Enterprises Inc2013-08-20Not applicableCanada
Lidocaine Hydrochloride Topical Solution USPSolution4 %TopicalTeligent OuNot applicableNot applicableCanada
Lidocaine Ointment USPOintment5 %TopicalTeligent OuNot applicableNot applicableCanada
Lidocaine Ointment USP, 5%Ointment5 %TopicalNovocol Pharmaceutical Of Canada IncNot applicableNot applicableCanada
Lidocaine Plus Maximum Strength Pain Relieving CreamCream39.2 mg/mLTopicalPrime Enterprises Inc.2007-03-02Not applicableUs
Lidocare MistSpray20 mg/mLTopicalSesvalia USA LLC2014-04-04Not applicableUs
LidocollSpray4.6 g/115gTopicalInnocoll Pharmaceuticals2011-01-01Not applicableUs
Lidocream 10Cream10 g/100gTopicalGolden Touch LLC2015-05-05Not applicableUs
Lidocream 4Cream4 g/100gTopicalGolden Touch LLC2010-12-01Not applicableUs
Lidocream 5Cream5 g/100gTopicalGolden Touch LLC2010-12-01Not applicableUs
Lidocream 5Cream5 g/100gTopicalGolden Touch LLC2010-12-01Not applicableUs
Lidocream 5Cream5 g/100gTopicalGolden Touch LLC2010-12-01Not applicableUs
Lidodan Cream 4%Cream4 %TopicalOdan Laboratories LtdNot applicableNot applicableCanada
Lidodan Cream 5%Cream5 %TopicalOdan Laboratories LtdNot applicableNot applicableCanada
Lidodan Jelly 2%Jelly20 mgTopicalOdan Laboratories Ltd2002-03-27Not applicableCanada
Lidodan Viscous 2%Liquid2 %BuccalOdan Laboratories Ltd1994-12-31Not applicableCanada
LidoflexPatch29 mg/.24mgTopicalNaimco, Inc. Dba Richmar, Inc.2014-09-01Not applicableUs
LidoflexPatch25.3 mg/.24mgTopicalNaimco, Inc. Dba Richmar, Inc.2014-09-01Not applicableUs
LidoflexPatch28.1 mg/.24mgTopicalNaimco, Inc. Dba Richmar, Inc.2014-09-01Not applicableUs
LidoflexPatch22.7 mg/.24mgTopicalNaimco, Inc. Dba Richmar, Inc.2014-09-01Not applicableUs
LidoflexPatch25.8 mg/.24mgTopicalNaimco, Inc. Dba Richmar, Inc.2014-09-01Not applicableUs
Lidoflex Elbow, Single PouchPatch21.5 mg/.24mgTopicalNaimco, Inc. Dba Richmar, Inc.2014-09-01Not applicableUs
Lidomax 5Cream5 %TopicalVivier Canada Incorporated2007-10-032014-07-16Canada
Lidoplus Pain ReliefCream40 mg/mLTopicalCentura Pharmaceuticals, Inc2015-12-25Not applicableUs
Lidosport Pain ReliefCream40 mg/mLTopicalCentura Pharmaceuticals, Inc2015-12-25Not applicableUs
LidostatCream40 mg/gTopicalClinical Therapeutic Solutions2013-06-19Not applicableUs
Lifestyles Epic Male Genital DesensitizerSpray10 mg/.1mLTopicalAnsell Healthcare Inc2011-11-022016-01-20Us
Lmx4Cream40 mg/gTopicalFerndale Laboratories, Inc.2011-01-03Not applicableUs
Lmx5Cream50 mg/gTopicalFerndale Laboratories, Inc.2003-10-01Not applicableUs
Lyracaine GelGel5 %TopicalProllenium Medical Technologies Inc2014-09-04Not applicableCanada
Male Genital Desensitizer Stud 100Spray, metered9.6 mg/100mLTopicalPound International Corp2013-03-13Not applicableUs
Male Genital Desensitizer Stud 100Spray, metered9.6 mg/100mLTopicalFleet Laboratories Ltd2013-03-13Not applicableUs
Maxilene 4Cream4 %TopicalRgr Pharma Ltd.2003-05-15Not applicableCanada
Maxilene 5Cream5 %TopicalRgr Pharma Ltd.2003-05-15Not applicableCanada
Med NumbSpray40 mg/gTopicalAtlas Tat Inc.2015-10-01Not applicableUs
Medi-first BurnGel20 mg/gTopicalUnifirst First Aid Corporation2014-07-30Not applicableUs
Medifirst BurnSpray20 g/LTopicalUnifirst First Aid Corporation2013-04-12Not applicableUs
Meijer Burn Relief Aloe Vera Pain Relieving GelGel.5 g/100gTopicalMeijer Distribution Inc2013-07-12Not applicableUs
Microcaine Topical AnalgesicCream50 mg/gTopicalUnit Dose, Ltd.2016-01-19Not applicableUs
Naturally Hl Extra Strength Bedsore NumbingLiquid40 mg/1000mgTopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Bedsore NumbingCream40 mg/1000mgTopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Burn NumbingCream40 mg/1000mgTopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Burn NumbingLiquid40 mg/1000mgTopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Hemorrhoid NumbingCream40 mg/1000mgTopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Hemorrhoid NumbingLiquid40 mg/1000mgTopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Insect Bite NumbingCream40 mg/1000mgTopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Insect Bite NumbingLiquid40 mg/1000mgTopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength NumbingLiquid40 mg/1000mgTopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength NumbingCream40 mg/1000mgTopicalRidge Properties2016-04-06Not applicableUs
Neuromed 7 Topical Pain ReliefCream4 g/100gTopicalSambria Pharmaceuticals, Llc2013-08-15Not applicableUs
Neuromed ArCream50 mg/mLTopicalSambria Pharmaceuticals, Inc.2015-08-042016-10-13Us
Neuromed Topical Anesthetic 7Cream40 mg/gTopicalSambria Pharmaceuticals2015-08-20Not applicableUs
No-AD Aloe Vera Gel 98% PureGel0.5 %TopicalSolar Cosmetic Labs, Inc.2001-01-062005-07-26Canada
No-AD Sunburn Relief GelGel0.5 %TopicalSolar Cosmetic Labs, Inc.2003-02-012005-07-26Canada
North Burn ReliefSpray24.64 mg/mLTopicalNorth Safety Products2013-03-15Not applicableUs
Numb 100Cream50 mg/gTopicalClinical Resolution Laboratory, Inc.2016-06-18Not applicableUs
Numb 520Cream5 mg/gTopicalClinical Resolution Laboratory, Inc.2015-12-18Not applicableUs
Numb MasterCream5 mg/gTopicalClinical Resolution Laboratory, Inc.2014-04-24Not applicableUs
Numb NutsCream4 g/100gTopicalMiss Smarty Pants Enterprises, Inc.2010-06-10Not applicableUs
Numb SkinCream5 mg/30gTopicalSeenext Venture Ltd2016-09-01Not applicableUs
Numb ZoneGel5 g/100gTopicalEsba Laboratories Inc.2015-07-01Not applicableUs
Number 5Cream5 %TopicalAlera Skin Care Products Inc.Not applicableNot applicableCanada
Numbing LabelSpray.04 mg/mgTopicalI. Shay Cosmetics2013-01-02Not applicableUs
Numbs UpGel40 mg/mLTopicalSambria Pharmaceuticals, Inc.2015-04-122017-04-28Us
Ocean Potion Instant Burn Relief IceGel.5 g/100gTopicalSun & Skin Care Research, LLC2012-01-01Not applicableUs
Pain Prescriptives 4Cream40 mg/gTopicalSambria Pharmaceuticals2015-08-202017-11-18Us
Pain Prescriptives 4Lotion40 mg/4mLTopicalSambria Pharmaceuticals, Llc2016-02-012016-02-04Us
Pain Prescriptives 5Cream50 mg/mLTopicalSambria Pharmaceuticals2015-12-222018-05-23Us
Pain Relief CvsCream4 g/100gTopicalCVS2016-03-15Not applicableUs
Pain Relief Well At WalgreensCream4 g/100gTopicalWalgreens2015-07-30Not applicableUs
Panama Jack Burn Relief Gel With LidocaineGel7.13 mg/mLTopicalPrime Enterprises Inc.2015-10-19Not applicableUs
Paraid BurnGel2 mg/gTopicalMcure Health Solutions Inc.2015-12-25Not applicableUs
Planticin Advanced Topical Pain ReliefCream40 mg/gTopicalPedicis Research, Llc2016-04-21Not applicableUs
Plum Smooth Plumb Numb GeleeGel4 g/100gTopicalUniversal Companies, Inc.2012-03-29Not applicableUs
PMS-lidocaine Viscous 2%Liquid2 %DentalPharmascience Inc1990-12-31Not applicableCanada
Pre-wax Pain ReliefSpray2.6 %TopicalAvon Canada Ulc2006-05-112007-07-26Canada
Pre-wax SpraySpray4 %TopicalProduct Excellence Inc.2008-01-312010-03-04Canada
PredatorCream40 mg/gTopicalSambria Pharmaceuticals, Llc2012-12-01Not applicableUs
PredatorCream400 mg/mgTopicalSambria Pharmaceuticals, Llc2013-02-11Not applicableUs
PredatorCream400 mg/mgTopicalSambria Pharmaceuticals, Llc2013-02-11Not applicableUs
PremjactSpray, metered9.6 %TopicalPound International Ltd.Not applicableNot applicableCanada
Premjact Male Desensitizer Pound InternationalSpray, metered9.6 g/100mLTopicalPound International2013-05-09Not applicableUs
Premjact Male Desensitizer Pound InternationalSpray, metered9.6 g/100mLTopicalFleet Laboratories Ltd2013-05-09Not applicableUs
PromescentSpray10 g/100gTopicalAbsorption2013-01-11Not applicableUs
Publix Burn ReliefGel.5 g/100gTopicalPublix Super Markets Inc2012-11-15Not applicableUs
Publix Burn Relief Aloe VeraGel.5 g/100gTopicalPublix Super Markets Inc2013-07-12Not applicableUs
Recovery NumbCream.05 g/gTopicalSambria Pharmaceucals, Inc.2013-03-222017-06-29Us
RectasmootheCream5 g/100gTopicalLeading Pharma, Llc2011-04-01Not applicableUs
RecticareCream50 mg/gTopicalFerndale Laboratories, Inc.2012-03-09Not applicableUs
Regenecare HaGel20 mg/mLTopicalMPM Medical, Inc.2009-06-01Not applicableUs
Regenecare HaGel20 mg/gTopicalMPM Medical, Inc.2007-01-05Not applicableUs
Regenecare HydrogelGel2 %TopicalMethapharm IncNot applicableNot applicableCanada
Res-Q Analgesic Topical Pain ReliefLiquid40 mg/mLTopicalConair Corporation2014-02-26Not applicableUs
Res-Q Analgesic Topical Pain Relief SpraySpray4 %TopicalDtr Dermal Therapy Research Inc.2014-08-18Not applicableCanada
Res-Q Topical Analgesic SoothingGel4 g/100gTopicalConair Corporation2014-02-26Not applicableUs
Res-Q Topical Analgesic Soothing GelGel4 %TopicalDtr Dermal Therapy Research Inc.2014-08-18Not applicableCanada
Rite Aid Burn ReliefGel.5 g/100gTopicalRite Aid Corporation2012-12-03Not applicableUs
Safetec Burn GelGel2 %TopicalSafetec Of America Inc2001-11-012013-08-07Canada
Safetec Burn SpraySpray2 %TopicalSafetec Of America Inc2002-07-292013-08-07Canada
Safetec Sting ReliefSolution2 %TopicalSafetec Of America Inc2001-11-012014-09-09Canada
Salonpas Lidocaine Pain RelievingPatch560 mg/1Percutaneous; Topical; TransdermalHisamitsu Pharmaceutical Co., Inc.2016-08-01Not applicableUs
SanobaSpray1.1 g/12gTopicalMyungmoon Pharm. Co.,ltd2016-07-15Not applicableUs
Select Brand Burn ReliefGel.5 g/100gTopicalSelect Brand Distributors2012-11-19Not applicableUs
Shave ZoneGel2.0 %TopicalCCA Industries, Inc.Not applicableNot applicableCanada
Simplicity DesensitizingGel40 mg/mLTopicalSimplicity Laser, LLC2014-07-15Not applicableUs
Simply Numb EndureCream5 g/100gTopicalGolden Touch LLC2014-07-08Not applicableUs
Simply Numb EndureCream5 g/100gTopicalGolden Touch LLC2014-07-08Not applicableUs
Simply Numb EndureCream5 g/100gTopicalGolden Touch LLC2014-07-08Not applicableUs
Simply Numb EndureCream5 g/100gTopicalGolden Touch LLC2014-07-08Not applicableUs
Skin Envy Soothing CreamCream2 %TopicalFarleyco Marketing, Inc.2014-02-04Not applicableCanada
Smartshield After SunGel1 %TopicalSmartshield Sunscreens2004-11-08Not applicableCanada
SolarcaineSpray5 mg/gTopicalBayer Health Care2012-04-06Not applicableUs
Solarcaine Cool AloeGel.5 g/100gTopicalBayer Health Care Llc2012-03-13Not applicableUs
Solarcaine First Aid Lidocaine SprayAerosol0.5 %TopicalBayer Inc Consumer Care1990-12-31Not applicableCanada
Solarcaine Medicated First Aid LotionLotion0.5 %TopicalBayer Inc Consumer Care1997-05-12Not applicableCanada
Solarcaine Medicated Lidocaine GelGel0.5 %TopicalBayer Inc Consumer Care2006-02-01Not applicableCanada
Sole SerumSpray4 g/100mLTopicalTHE COMFORT LAB LLC2014-02-24Not applicableUs
Solmate Burn Relief GelGel.057 mg/mLTopicalPrime Enterprises, Inc.2015-04-01Not applicableUs
Sonacaine Topical Anesthetic With MentholGel4 g/100gTopicalFilltech Usa, Llc2012-05-02Not applicableUs
Soothing Gel With LidocaineGel0.50 %TopicalEnergizer Canada Inc2008-02-142015-08-14Canada
Soulus Rp Rash and PainCream.5 g/100gTopicalPure Source Inc2011-03-23Not applicableUs
StallionSpray, metered9.6 %TopicalLockerroom Marketing Ltd2008-06-26Not applicableCanada
Stud 100Spray, metered9.6 %TopicalPound International Ltd.1997-07-15Not applicableCanada
Sunburn ReliefAerosol0.5 %TopicalTender CorporationNot applicableNot applicableCanada
Suntone After Sun Burn Relief Gel With LidocaineGel7.13 mg/mLTopicalPrime Enterprises Inc.2011-11-07Not applicableUs
Swabplus Piercing Care SwabsSwab1 %TopicalSwabplus Canada Inc.2003-06-152008-09-22Canada
Swiss Navy Endurance Rx ProSpray10 mg/mLTopicalMd Science Lab, Llc2016-04-28Not applicableUs
Topicaine 5Gel5 g/100gTopicalEsba Laboratories Inc.2003-04-20Not applicableUs
Topicaine 5Gel5 %TopicalEsba Laboratories Inc2009-03-01Not applicableCanada
Topical Anesthetic Anorectal Cream Numb and NumberCream5 g/100gTopicalDermtech Labs Inc. Dba Gd Labs2016-08-11Not applicableUs
UnburnSpray2.5 g/100mLTopicalWater Jel Technologies2014-02-01Not applicableUs
UnburnGel2.5 g/100mLTopicalWater Jel Technologies2013-03-17Not applicableUs
Unburn-gel 2.5%Gel2.5 %TopicalWater Jel Technologies,Llc1997-03-031997-07-03Canada
Walgreens Aloe Vera Burn Relief Pain RelievingGel.5 g/100gTopicalWALGREEN CO.2012-12-04Not applicableUs
Water-jel Burn Jel-2%Gel2 %TopicalZEE MEDICAL1994-12-31Not applicableCanada
Watkins Burn CreamCream1 %TopicalWatkins Incorporated1998-07-012000-02-02Canada
Western Family Aloe Vera MoisturizingGel.5 g/100gTopicalWestern Family Foods, Inc.2014-07-02Not applicableUs
X3 On The Go First Aid Bite Relief SpraySolution2 %TopicalNatural Essentials IncNot applicableNot applicableCanada
X3 On The Go First Aid Burn Relief SpraySolution0.5 %TopicalNatural Essentials IncNot applicableNot applicableCanada
X3 On-the-GO First Aid Burn Relief SpraySpray0.5 %TopicalNatural Essentials Inc2012-04-24Not applicableCanada
XolidoCream4 g/mLTopicalEnovachem Manufacturing2013-04-05Not applicableUs
XolidoCream2 g/mLTopicalEnovachem Manufacturing2013-04-05Not applicableUs
Xylocaine MpfLiquid1 %Intraspinal; PercutaneousAstrazeneca L.P.1997-05-212001-10-12Canada
Yowch Extra Strength for Insect Bites and StingsCream40 mg/1000mgTopicalRidge Properties Llc2015-11-30Not applicableUs
Yowch Extra Strength for Minor BurnsCream40 mg/1000mgTopicalRidge Properties2015-11-30Not applicableUs
Yowch for Insect Bites and Stings By Pain BalmCream20 mg/1000mgTopicalRidge Properties2015-09-07Not applicableUs
Yowch for Minor Burns By Pain BalmCream20 mg/1000mgTopicalRidge Properties2015-09-07Not applicableUs
Zcaine Fast Acting AnestheticGel4 g/100gTopicalPHI, Inc2012-04-04Not applicableUs
ZensaCream5 %TopicalAlera Skin Care Products Inc.2016-05-20Not applicableCanada
ZensaCream5 g/100gTopicalAlera Skin Care Products Inc.2016-01-04Not applicableUs
Zilactin-LLiquid2.5 %TopicalZila Pharmaceuticals Inc.1998-02-172006-07-04Canada
Zilactin-L Early Relief Cold Sore LiquidSolution4.0 %TopicalBlairex Laboratories, Inc.2005-06-022008-07-23Canada
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apicaine-XOintment.05 g/gTopicalMedicap Laboratories Inc.2015-12-122016-02-19Us
CidaleazeCream30 mg/gTopicalAlvix Laboratories, LLC2015-08-11Not applicableUs
Dermacinrx LidotralCream38.8 mg/gTopicalPure Tek Corporation2015-12-03Not applicableUs
EhaLotion4 g/mLTopicalAsclemed Usa, Inc.2016-06-07Not applicableUs
LidocaineOintment5 g/100gTopicalTwo Hip Consulting, Llc2016-03-25Not applicableUs
Lidocaine HClCream30 mg/gTopicalPure Tek Corporation2011-06-13Not applicableUs
Lidocaine HClInjection, solution20 mg/mLInfiltrationCantrell Drug Company2015-02-25Not applicableUs
Lidocaine HydrochlorideGel30 mg/gTopicalAidarex Pharmaceuticals LLC2013-03-01Not applicableUs
Lidocaine HydrochlorideGel30 mg/gTopicalLake Erie Medical DBA Quality Care Products LLC2013-03-01Not applicableUs
Lidocaine HydrochlorideCream30 mg/gTopicalSeton Pharmaceuticals2011-06-20Not applicableUs
Lidocaine HydrochlorideGel30 mg/gTopicalGensco Laboratories, LLC2013-03-01Not applicableUs
Lidocaine HydrochlorideGel30 mg/gTopicalA S Medication Solutions2013-03-01Not applicableUs
Lidocaine HydrochlorideLotion3 g/100mLTopicalAlvix Laboratories,Llc2015-03-02Not applicableUs
Lidocaine HydrochlorideGel30 mg/gTopicalProficient Rx LP2013-03-012016-01-05Us
Lidocaine HydrochlorideGel30 mg/gTopicalUnit Dose Services2013-03-01Not applicableUs
Lidocaine HydrochlorideLotion5.31 mL/177mLTopicalStratus Pharamceuticals2012-03-01Not applicableUs
Lidocaine Hydrochloride ViscousGel2 g/100mLOralTrue Fit Rx Llc2015-07-06Not applicableUs
LidocinGel7.2 g/240gTopicalPharmaceutics Corporation2015-02-202015-12-29Us
LidopinCream32.5 mg/gTopicalAdler Stern Pharmaceuticals, Llc2014-11-11Not applicableUs
LidovexCream37.5 mg/gTopicalSterling Knight Pharmaceuticals, Llc2014-12-14Not applicableUs
LidovinCream39.5 mg/gTopicalSterling Knight Pharmaceuticals,Llc2015-04-30Not applicableUs
LidozolCream37.5 mg/gTopicalSterling Knight Pharmaceuticals,Llc2015-04-30Not applicableUs
MericaineGel.04 g/gTopicalMerit Pharmaceutical2015-07-01Not applicableUs
Premium Lidocaine 5% ExtraOintment.005 mg/gTopicalZhejiang Bangli Medical Products Co., Ltd2015-03-012016-10-13Us
Premium Lidocaine 5% ExtraOintment.005 mg/gTopicalAlivio Medical Products, Llc2015-03-01Not applicableUs
International Brands
NameCompany
After Burn Double Strength GelNot Available
After Burn Double Strength SprayNot Available
After Burn GelNot Available
After Burn SprayNot Available
AlphacaineNot Available
Anestacon JellyNot Available
DermaFlexNot Available
DilocaineNot Available
EsracaineNot Available
L-CaineNot Available
Lidoject-1Not Available
Lidoject-2Not Available
LidoPain SPNot Available
Norwood Sunburn SprayNot Available
XylocardNot Available
Brand mixtures
NameLabellerIngredients
0.4% Lidocaine Hydrochloride and 5% Dextrose Injection USPHospira Healthcare Corporation
10 Person AnsiGenuine First Aid LLC
1st Relief Topical1st Class Pharmaceuticals, Inc.
2% Lidocaine and Epinephrine 1:100,000 Injection USPAlveda Pharmaceuticals Inc
25 Person AnsiGenuine First Aid LLC
3-step First Aid KitSwabplus Inc.
5% Xylocaine Mpf With Glucose 7.5% InjectionSmiths Medical Canada Ltd.
50 Person AnsiGenuine First Aid LLC
Acme First Aid Contains 404 PiecesAcme United Corp.
Acme Small Cuts and BurnsAcme United Corp.
AdazinSterling Knight Pharmaceuticals, Llc
Aerowound Blood Clotting First AidAero Healthcare, Llc.
Aflexeryl-LCEasy Distributors, Llc
After Bite WipeTender Corporation
After Cuts and ScrapesTender Corporation
AlocaneQuest Products, Inc.
Alocane PlusQuest Products, Inc.
Aloe Vera GelMeijer Distribution
Ana-lexAvion Pharmaceuticals, Llc
AnodynerxGen Pak Solutions Llc
Antibiotic Cream for KidsTaro Pharmaceuticals Inc
Antibiotic Cream Plus Pain ReliefPharmetics (2011) Inc
Antibiotic Cream Plus Pain Relief for KidsCanadian Custom Packaging Company
Antibiotic Plus Pain Relief CreamTaro Pharmaceuticals Inc
AntisepticSafetec of America, Inc.
Antiseptic Formula Filled SwabSwabplus Inc.
Apr15Aleviar Pharma Corp
Arc Emergency Preparedness First Aid Contains 202 PiecesAmerican Red Cross
Arc First Aid Contains 1000 PiecesAmerican Red Cross
Arc First Aid Contains 101 PiecesAmerican Red Cross
Arc First Aid Contains 101 Pieces HardcaseAmerican Red Cross
Arc First Aid Contains 404 PiecesAmerican Red Cross
Arrow Central Venous Catheterization KitArrow International Inc.
Arrow Multi-lumen Central Venous Catheter KitArrow International Inc.
Arrow Pneumothorax KitArrow International Inc.
Arrow Two-lumen Central Venous Cathetar KitArrow International Inc.
Arrow Two-lumen Jugular Catheterization KitArrow International Inc.
Aubio Life Sciences LipAubio Life Sciences Llc
Auto 157Genuine First Aid LLC
AvadermPure Source, Inc.
Avalin External Analgesic PatchRx Change Co.
Avon Foot Works Therapeutic Cracked Heel Relief CreamAvon Canada Ulc
Baciguent Plus Pain Reliever OntUpjohn Consumer Products Company
Bactine First Aid SprayWellspring Pharmaceutical Canada Corp
Bactine First Aid Spray LiqMiles Canada Inc. Consumer Health Care Division
Bactine Original First AidBayer Health Care Llc, Consumer Care
Bactine Pain RelievingBayer Health Care Llc, Consumer Care
Bakers Best Arthritis Pain ReliefBaker's Best
Banana Boat Sooth-A-caine Spray GelPlaytex Ltd.
Banana Boat Sooth-A-caine W.moist.aloe V.gelThe Banana Boat Company
Band-aid Brand Hurt-free Antiseptic Pain RelievingJohnson & Johnson Consumer Inc.
Band-aid Brand Hurt-free Antiseptic WashJohnson & Johnson Consumer Inc.
Bekoool Itch ReliefKobayashi America Manufacturing, Llc
Bene PatchZhejiang Bangli Medical Products Co., Ltd
BenepatchMeds Direct Rx, Inc.
Benzalkonium Chloride and Lidocaine HydrochlorideCVS Pharmacy
Biochemistry Pain Relief Foot ActivePure Source, Inc.
Biotic-plusProvision Medical
Blood Clotting First AidUnifirst First Aid Corporation
Braline PatchDoc Rx
Budpak First AidBudpak Inc.
Burn Relief CreamHumn Pharmaceuticals Inc
Burn Relief Extra Strength Kool-downKool Down Inc.
Burn Relief GelEnergizer Canada Inc
Burn Relief Kol-downKool Down Inc.
Burn Relief Professional Kool-downKool Down Inc.
Burn TreatmentCmc Group Inc.
Burn With LidocaineUnifirst First Aid Corporation
Burncare KitAvacare, Division Of Jeunique International Inc.
CacitrixOrimed Pharma Corporation
CaustinerfSeptodont
Central Vein Catheterization KitArrow International Inc.
Central Venous Catetherization KitArrow International Inc.
Central Venous Catheter Expanded KitEdwards Lifesciences (Canada) Inc.
CicloferonMarcas Usa Llc
Coachs First Aid Contains 102 PiecesCramer Sports
Comfort Ez Extra Strength Pain Relief PatchSimple Diagnostics, Inc.
Comfort Ez Extra Strengthtransdermal PatchSimple Diagnostics, Inc.
Comfort Ez Pain Relief PatchSimple Diagnostics, Inc.
Complete Antibiotic OintmentTaro Pharmaceuticals Inc
Continuous Epidural Anesthesia TrayBaxter Corporation
Cvs Antiseptic WashCVS Pharmacy
Cvs Bacitracin With Pain ReliefCVS Pharmacy
De LA Cruz MercurochromeDLC Laboratories, Inc.
Dentsply 2% Lidocaine With Epinephrine 1:100,000Dentsply Canada Limited
Dentsply 2% Lidocaine With Epinephrine 1:50,000Dentsply Canada Limited
Depo-medrol With LidocainePfizer Canada Inc
Derma-caineUnifirst First Aid Corporation
Dermacinrx Cinlone-I CpiPure Tek Corporation
Dermacinrx Cinlone-II CpiPure Tek Corporation
Dermacinrx EmpricainePure Tek Corporation
Dermacinrx LexifenPure Tek Corporation
Dermacinrx PrikaanShoreline Pharmaceuticals, Inc.
Dermacinrx PrizopakPure Tek Corporation
Dermatologic ReliefJamp Pharma Corporation
Dipentocaine Topical Cream Compounding KitAlvix Laboratories, LLC
Disposable Convenience Kit (single Shot Epidural)True Fit Rx Llc
Doans Pain RelievingDr. Reddy's Laboratories Inc.
Dolor-parche With Lidocaine-RXTwo Hip Consulting, Llc
Doloracin/l Rx With LidocaineTwo Hip Consulting, Llc
Dr. Scholl's Cracked Heel Relief CreamSchering Plough Canada Inc
Dynarex Burn CreamDynarex Corporation
Elite Pain ReliefMeds Direct Rx, Inc.
EmlaActavis Pharma, Inc.
Emla CrmAstrazeneca Canada Inc
Emla PatchAstrazeneca Canada Inc
EndoxcinPharmaceutica North America, Inc.
Epidural Anesthesia TrayBaxter Corporation
Expanded Multi-med KitEdwards Lifesciences (Canada) Inc.
Family Medic First Aid Treatment - LiqTender Corporation
Family Medic First-aid Treatment LiquidTender Corporation
Family Medic First-aid Treatment LotionTender Corporation
First AidProvision Medical
First Aid and BurnAcme United Corporation
First Aid Antiseptic Pain RelievingGfa Production (Xiamen) Co., Ltd.
First Aid Antiseptic SwabsAvon Canada Ulc
First Aid Antiseptic Well At WalgreensWalgreens
First Aid BurnWater Jel Technologies
First Aid Burn CreamDavemed Healthcare Co., Ltd
First Aid Contains 101 PiecesGenuine First Aid LLC
First Aid Contains 101 Pieces HardcaseGenuine First Aid LLC
First Aid Contains 303 PiecesGenuine First Aid LLC
First Aid Macimum Sterngth Bacitraycin PlusFirst Aid Research Corp
First Aid Pocket Pack - 40 PiecesReady America, Inc.
First Aid Research Bacitraycin Plus Maximum VerticalFirst Aid Research Corp.
First Aid SprayNorwood Packaging Ltd
First Aid Triple Antibiotic With Pain RelieverCintas First Aid & Safety
First Aid Value Pack - 77 PiecesReady America, Inc.
FonowZhejiang Reachall Pharmaceutical Co., Ltd.
Foot Works Cracked HeelAvon Products, Inc.
Foot Works Healthy Cracked Heel CreamAvon Canada Ulc
Footworks Healthy Cracked Heel CreamAvon Canada Ulc
Footworks Maximum Strength Cracked HeelNew Avon Llc
FortacinPlethora Solutions Limited
Freds Antiseptic WashPharma Pac, Llc
Genetic Amniocentesis Tray KitAllegiance Healthcare Corporation
Genuine First Aid BurnGfa Production (Xiamen) Co., Ltd.
Genuine First Aid Burn Antiseptic Pain Relief With AloeGenuine First Aid
Good Neighbor Pharmacy Emergency Preparedness and First Aid Contains 167 PiecesAmerisource Bergen
Good Neighbor Pharmacy First Aid Contains 202 PiecesAmerisource Bergen
Green Guard Derma-caineUnifirst First Aid Corporation
Green Guard Super Stat Blood Clotting First AidUnifirst First Aid Corporation
Healerz for NosesWellco Brands LLC
HemawayMelaleuca, Inc.
Hemorrhoid and Fissure Dr. ButlerBeyond Health p.a.
Humco MercuroclearHumco Holding Group, Inc
Hush AnestheticHUSH Anesthetic
Hyaluronic Acid 60mg and Lidocaine 2% PFUs Compounding, Inc
Hydrocath Central Venous Catheter KitOhmeda (Singapore) Pte Ltd.
Icy Hot With Lidocaine Pain RelievingChattem, Inc.
InstillagelPendopharm Division Of De Pharmascience Inc
Itch Relief CreamHumn Pharmaceuticals Inc
IV Infusion CpiPure Tek Corporation
Jamshidi Bone Marrow Biopsy TrayAllegiance Healthcare Corporation
Jamshidi Menghini Soft Tissue Biopsy TrayAllegiance Healthcare Corporation
K-mart Smartsense First Aid Contains 101 PiecesK Mart
Kds Lab Liquid StypticKds Lab
Keepan ASato Pharmaceutical Co., Ltd.
Kroger Aloe Vera Pain RelievingThe Kroger Co
Large Ansi First Aid KitCmc Group, Inc.
LenzagelPharmaceutica North America, Inc.
LenzapatchPharmaceutica North America, Inc.
LexilidoAlexso, Inc.
LidallMed Vantage Pharmaceutical, Llc
Lidenza PatchPatchwerx Labs, Inc.
Lido-RX 4.1Cloverleaf Pharma Llc
LidocaineHenry Schein Inc.
Lidocaine 0.2% In 5% Dextrose InjHospira Healthcare Corporation
Lidocaine 2.5% and Prilocaine 2.5% CreamWelgo, Llc
Lidocaine 2% and Epinephrine 1:100 000Kodak Canada Inc.
Lidocaine 2% and Epinephrine 1:100,000Carestream Health Canada Company
Lidocaine 2% and Epinephrine 1:100,000 InjectionTeligent Ou
Lidocaine 2% and Epinephrine 1:50 000Kodak Canada Inc.
Lidocaine 2% and Epinephrine 1:50,000Carestream Health Canada Company
Lidocaine and Epinephrine Inj.usp 2% 1:100000Mylan Pharmaceuticals Ulc
Lidocaine and PrilocaineActavis Pharma, Inc.
Lidocaine HClPearson Dental
Lidocaine HCl - Hydrocortisone AcetatePure Tek Corporation
Lidocaine HCl - Hydrocortisone Acetate With AloePure Tek Corporation
Lidocaine HCl 0.2% and Dextrose 5% InjBaxter Corporation
Lidocaine HCl 0.4% and 5% Dextrose InjBaxter Corporation
Lidocaine HCl 0.8% and 5% Dextrose InjBaxter Corporation
Lidocaine HCl and Dextrose 5% Inj USPB. Braun Medical Inc
Lidocaine HCl and Hydrocortisone AcetateAcella Pharmaceuticals, LLC
Lidocaine Hydrochloride 0.5% and Epinephrine 1:200000 Injection USPHospira Healthcare Corporation
Lidocaine Hydrochloride 1.5% and Epinephrine 1:200000 Injection USPHospira Healthcare Corporation
Lidocaine Hydrochloride 1.5% and Epinephrine 1:200000 Injection USP Test DoseHospira Healthcare Corporation
Lidocaine Hydrochloride 1% and Epinephrine 1:100 000 Injection USPHospira Healthcare Corporation
Lidocaine Hydrochloride 2% and Epinephrine 1:100 000 Injection USPHospira Healthcare Corporation
Lidocaine Hydrochloride 2% and Epinephrine 1:200000 Injection USPHospira Healthcare Corporation
Lidocaine Hydrochloride and 5% Dextrose Injection USPB. Braun Medical Inc
Lidocaine Hydrochloride and DextroseB. Braun Medical Inc.
Lidocaine Hydrochloride and EpinephrineHospira, Inc.
Lidocaine Hydrochloride and Epinephrine BitartrateIq Dental
Lidocaine Hydrochloride and Hydrocortisone AcetateSeton Pharmaceuticals
Lidocaine Pain Relief PatchFoshan Aqua Gel Biotech Co.,ltd.
Lidocaine-prilocaine-cream BaseHumco Holding Group, Inc.
LidomyxinSandoz Canada Incorporated
LidonexePatchwerx Labs, Inc.
LidopatchJar Laboratories
Lidopatch Pain Relief3 T Federal Solutions Llc
Lidoplus Pain Relief PatchCentura Pharmaceuticals Inc
LidoprilSterling Knight Pharmaceuticals,Llc
Lidopril XRSterling Knight Pharmaceuticals,Llc
LidoproPreferred Pharmaceuticals, Inc.
Lidopro PatchPreferred Pharmaceuticals Inc.
Lidosporin CreamGlaxo Wellcome Inc.
Lidosporin Ear DropsGlaxo Wellcome Inc.
Lidosport Pain Relief PatchCentura Pharmaceuticals Inc
LidotholTerrain Pharmaceuticals
Lignospan ForteNovocol Pharmaceutical of Canada, Inc.
Lignospan Speciale InjSeptodont
Lignospan StandardNovocol Pharmaceutical of Canada, Inc.
LimencinAlexso Inc
LiprotekUnit Dose, Ltd.
Lipsorex PlusSanofi Consumer Health Inc Sanofi Sante Grand Public Inc
Lorenza Pain Relief PatchHome Aide Diagnostics, Inc.
Makesense First AidCherry Hill Sales Co
Medi-derm / L With LidocaineTwo Hip Consulting, Llc
Medi-derm / L With Lidocaine RxTwo Hip Consulting, Llc
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Salts
Name/CASStructureProperties
Lidocaine hydrochloride
6108-05-0
Thumb
  • InChI Key: YECIFGHRMFEPJK-UHFFFAOYSA-N
  • Monoisotopic Mass: 288.1604558
  • Average Mass: 288.82
DBSALT000900
Lidocaine hydrochloride anhydrous
73-78-9
Thumb
  • InChI Key: IYBQHJMYDGVZRY-UHFFFAOYSA-N
  • Monoisotopic Mass: 270.1498911
  • Average Mass: 270.8
DBSALT001508
Categories
UNII98PI200987
CAS number137-58-6
WeightAverage: 234.3373
Monoisotopic: 234.173213336
Chemical FormulaC14H22N2O
InChI KeyNNJVILVZKWQKPM-UHFFFAOYSA-N
InChI
InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
IUPAC Name
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
SMILES
CCN(CC)CC(=O)NC1=C(C)C=CC=C1C
Pharmacology
IndicationFor production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.
Structured Indications
PharmacodynamicsLidocaine is an anesthetic agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Lidocaine appears to be similar to that of procaine, procainamide and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected. In contrast to the latter 3 drugs, Lidocaine in therapeutic doses does not produce a significant decrease in arterial pressure or in cardiac contractile force. In larger doses, lidocaine may produce circulatory depression, but the magnitude of the change is less than that found with comparable doses of procainamide.
Mechanism of actionLidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. Lidocaine alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation. With sufficient blockage the membrane of the postsynaptic neuron will not depolarize and will thus fail to transmit an action potential. This creates the anaesthetic effect by not merely preventing pain signals from propagating to the brain but by aborting their birth in the first place.
TargetKindPharmacological actionActionsOrganismUniProt ID
Sodium channel protein type 10 subunit alphaProteinyes
inhibitor
HumanQ9Y5Y9 details
Sodium channel protein type 9 subunit alphaProteinyes
inhibitor
HumanQ15858 details
Sodium channel protein type 5 subunit alphaProteinyes
inhibitor
HumanQ14524 details
Epidermal growth factor receptorProteinunknown
antagonist
HumanP00533 details
Related Articles
AbsorptionInformation derived from diverse formulations, concentrations and usages reveals that lidocaine is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon various factors such as the site of administration and the presence or absence of a vasoconstrictor agent.
Volume of distribution
  • 0.7 to 2.7 L/kg [healthy volunteers]
Protein binding60-80%
Metabolism

Primarily hepatic.

SubstrateEnzymesProduct
Lidocaine
3-hydroxylidocaineDetails
Lidocaine
monoethylglycinexylidideDetails
Lidocaine
Not Available
2,6-Dimethylaniline (2,6-Xylidine)Details
3-hydroxylidocaine
Not Available
3-HydroxymonoethylglycinexylidideDetails
monoethylglycinexylidide
Not Available
3-HydroxymonoethylglycinexylidideDetails
monoethylglycinexylidide
Not Available
2,6-Dimethylaniline (2,6-Xylidine)Details
monoethylglycinexylidide
Not Available
Glycinexylidide (GX)Details
Glycinexylidide (GX)
Not Available
2,6-Dimethylaniline (2,6-Xylidine)Details
2,6-Dimethylaniline (2,6-Xylidine)
Not Available
2-Amino-3-methylbenzoateDetails
2,6-Dimethylaniline (2,6-Xylidine)
Not Available
4-Hydroxy-2,6-dimethylanilineDetails
2,6-Dimethylaniline (2,6-Xylidine)
Not Available
2-Amino-3-methylbenzoateDetails
2,6-Dimethylaniline (2,6-Xylidine)
Not Available
2-Amino-3-methylbenzoateDetails
2,6-Dimethylaniline (2,6-Xylidine)
Not Available
4-Hydroxy-2,6-dimethylanilineDetails
2,6-Dimethylaniline (2,6-Xylidine)
Not Available
4-Hydroxy-2,6-dimethylanilineDetails
Route of eliminationLidocaine and its metabolites are excreted by the kidneys.
Half life109 minutes
Clearance
  • 0.64 +/- 0.18 L/min
ToxicityThe oral LD 50 of lidocaine HCl in non-fasted female rats is 459 (346-773) mg/kg (as the salt) and 214 (159-324) mg/kg (as the salt) in fasted female rats. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Lidocaine (Local Anaesthetic) Action PathwayDrug actionSMP00398
Lidocaine (Antiarrhythmic) Action PathwayDrug actionSMP00328
Lidocaine (Local Anaesthetic) Metabolism PathwayDrug metabolismSMP00620
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Lidocaine is combined with 1,1,1,2 Tetrafluoroethane.Investigational
7-NitroindazoleThe risk or severity of adverse effects can be increased when Lidocaine is combined with 7-Nitroindazole.Experimental
AbirateroneThe serum concentration of Lidocaine can be increased when it is combined with Abiraterone.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Lidocaine.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Lidocaine.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Aceprometazine.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Lidocaine.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Lidocaine.Approved, Vet Approved
adipiplonThe risk or severity of adverse effects can be increased when Lidocaine is combined with adipiplon.Investigational
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Lidocaine.Approved
AgomelatineThe serum concentration of Agomelatine can be increased when it is combined with Lidocaine.Approved, Investigational
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Lidocaine.Approved, Vet Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Lidocaine.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Lidocaine is combined with Alfentanil.Approved, Illicit
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Lidocaine.Approved, Investigational
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Lidocaine.Approved, Investigational
AlosetronThe metabolism of Alosetron can be decreased when combined with Lidocaine.Approved, Withdrawn
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Alphacetylmethadol.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Alprazolam.Approved, Illicit, Investigational
AlprenololThe serum concentration of Lidocaine can be increased when it is combined with Alprenolol.Approved, Withdrawn
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Lidocaine.Approved, Investigational
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Lidocaine.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Lidocaine.Approved
AmiodaroneThe metabolism of Lidocaine can be decreased when combined with Amiodarone.Approved, Investigational
AmiodaroneLidocaine may increase the arrhythmogenic activities of Amiodarone.Approved, Investigational
AmiodaroneThe serum concentration of Lidocaine can be increased when it is combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Amisulpride.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Lidocaine.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Amobarbital.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Amperozide.Experimental
AnagrelideThe metabolism of Anagrelide can be decreased when combined with Lidocaine.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Lidocaine.Approved
Aop200704The serum concentration of Lidocaine can be increased when it is combined with Aop200704.Investigational
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Lidocaine.Approved
AprepitantThe serum concentration of Lidocaine can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleThe risk or severity of adverse effects can be increased when Lidocaine is combined with Aripiprazole.Approved, Investigational
ArotinololThe serum concentration of Lidocaine can be increased when it is combined with Arotinolol.Approved
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Lidocaine.Approved, Investigational
ArtemetherThe metabolism of Lidocaine can be decreased when combined with Artemether.Approved
ArticaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Articaine.Approved
ASA404The metabolism of ASA404 can be decreased when combined with Lidocaine.Investigational
AsenapineThe metabolism of Asenapine can be decreased when combined with Lidocaine.Approved
AtazanavirThe metabolism of Lidocaine can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Lidocaine.Approved
AtomoxetineThe metabolism of Lidocaine can be decreased when combined with Atomoxetine.Approved
AV650The metabolism of AV650 can be decreased when combined with Lidocaine.Approved, Investigational
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Lidocaine.Approved, Investigational
AzaperoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Azaperone.Vet Approved
AzelastineLidocaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe metabolism of Azelastine can be decreased when combined with Lidocaine.Approved
AzithromycinThe metabolism of Lidocaine can be decreased when combined with Azithromycin.Approved
BaclofenThe risk or severity of adverse effects can be increased when Lidocaine is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Barbital.Illicit
BefunololThe serum concentration of Lidocaine can be increased when it is combined with Befunolol.Experimental
BendamustineThe metabolism of Bendamustine can be decreased when combined with Lidocaine.Approved, Investigational
BenperidolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Benzocaine.Approved
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Lidocaine.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Lidocaine.Approved, Vet Approved
BetaxololThe metabolism of Betaxolol can be decreased when combined with Lidocaine.Approved
BetaxololThe serum concentration of Lidocaine can be increased when it is combined with Betaxolol.Approved
BevantololThe serum concentration of Lidocaine can be increased when it is combined with Bevantolol.Approved
BexaroteneThe serum concentration of Lidocaine can be decreased when it is combined with Bexarotene.Approved, Investigational
BisoprololThe serum concentration of Lidocaine can be increased when it is combined with Bisoprolol.Approved
BoceprevirThe metabolism of Lidocaine can be decreased when combined with Boceprevir.Approved
BopindololThe serum concentration of Lidocaine can be increased when it is combined with Bopindolol.Approved
BortezomibThe metabolism of Lidocaine can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Lidocaine can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Lidocaine.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Lidocaine.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Lidocaine is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Lidocaine.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Lidocaine.Approved, Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Brotizolam.Approved, Withdrawn
BucindololThe serum concentration of Lidocaine can be increased when it is combined with Bucindolol.Investigational
BufuralolThe serum concentration of Lidocaine can be increased when it is combined with Bufuralol.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Lidocaine.Approved, Investigational
BupranololThe serum concentration of Lidocaine can be increased when it is combined with Bupranolol.Approved
BuprenorphineLidocaine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Lidocaine can be decreased when combined with Bupropion.Approved
BuspironeThe risk or severity of adverse effects can be increased when Lidocaine is combined with Buspirone.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Lidocaine.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Lidocaine is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Butethal.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Butorphanol.Approved, Illicit, Vet Approved
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Lidocaine.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Lidocaine.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Lidocaine.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Lidocaine.Approved
CapecitabineThe metabolism of Lidocaine can be decreased when combined with Capecitabine.Approved, Investigational
CarbamazepineThe metabolism of Lidocaine can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Lidocaine is combined with Carfentanil.Illicit, Vet Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Lidocaine.Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Carisoprodol.Approved
CarmustineThe metabolism of Carmustine can be decreased when combined with Lidocaine.Approved
CarteololThe serum concentration of Lidocaine can be increased when it is combined with Carteolol.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Lidocaine.Approved, Investigational
CarvedilolThe serum concentration of Lidocaine can be increased when it is combined with Carvedilol.Approved, Investigational
CelecoxibThe metabolism of Lidocaine can be decreased when combined with Celecoxib.Approved, Investigational
CeliprololThe serum concentration of Lidocaine can be increased when it is combined with Celiprolol.Approved, Investigational
CeritinibThe serum concentration of Lidocaine can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Lidocaine.Withdrawn
CetirizineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chlordiazepoxide.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chlormezanone.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chloroprocaine.Approved
ChloroquineThe metabolism of Lidocaine can be decreased when combined with Chloroquine.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chlorphenamine.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Lidocaine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Lidocaine.Approved
CholecalciferolThe metabolism of Lidocaine can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CilostazolThe metabolism of Cilostazol can be decreased when combined with Lidocaine.Approved
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Lidocaine.Approved
CinacalcetThe metabolism of Lidocaine can be decreased when combined with Cinacalcet.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Cinchocaine.Approved, Vet Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Lidocaine.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Lidocaine.Approved, Investigational
CisaprideThe metabolism of Cisapride can be decreased when combined with Lidocaine.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Lidocaine.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Lidocaine.Approved
ClarithromycinThe metabolism of Lidocaine can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Lidocaine can be decreased when combined with Clemastine.Approved
ClenbuterolThe metabolism of Clenbuterol can be decreased when combined with Lidocaine.Approved, Vet Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Lidocaine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Lidocaine is combined with Clidinium.Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Lidocaine.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Lidocaine is combined with clomethiazole.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Lidocaine.Approved, Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Lidocaine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Clonazepam.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Lidocaine.Approved
ClopidogrelThe metabolism of Lidocaine can be decreased when combined with Clopidogrel.Approved, Nutraceutical
ClorazepateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Clorazepate.Approved, Illicit
ClotrimazoleThe metabolism of Lidocaine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Lidocaine.Approved
CobicistatThe serum concentration of Lidocaine can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Lidocaine.Approved
CocaineThe metabolism of Lidocaine can be decreased when combined with Cocaine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Codeine.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Lidocaine.Approved
ConivaptanThe serum concentration of Lidocaine can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Lidocaine.Approved
CrizotinibThe metabolism of Lidocaine can be decreased when combined with Crizotinib.Approved
CyclizineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Cyclizine.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Lidocaine.Approved
CyclosporineThe metabolism of Lidocaine can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Cyproheptadine.Approved
Cyproterone acetateThe serum concentration of Lidocaine can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Lidocaine.Approved
DabrafenibThe serum concentration of Lidocaine can be decreased when it is combined with Dabrafenib.Approved
DacarbazineThe metabolism of Dacarbazine can be decreased when combined with Lidocaine.Approved, Investigational
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Lidocaine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dantrolene.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Lidocaine.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dapiprazole.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dapoxetine.Investigational
DapsoneThe risk or severity of adverse effects can be increased when Dapsone is combined with Lidocaine.Approved, Investigational
DarifenacinThe metabolism of Lidocaine can be decreased when combined with Darifenacin.Approved, Investigational
DarunavirThe serum concentration of Lidocaine can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Lidocaine can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Lidocaine.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Lidocaine.Approved
DeferasiroxThe serum concentration of Lidocaine can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Lidocaine can be decreased when combined with Delavirdine.Approved
deramciclaneThe risk or severity of adverse effects can be increased when Lidocaine is combined with deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Desflurane.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Lidocaine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Detomidine.Vet Approved
DexamethasoneThe serum concentration of Lidocaine can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dexbrompheniramine.Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Lidocaine.Approved, Illicit, Withdrawn
DexmedetomidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dexmedetomidine.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dextropropoxyphene.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dezocine.Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Lidocaine.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Lidocaine.Approved, Vet Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Lidocaine.Approved
DifenoxinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Difenoxin.Approved, Illicit
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Lidocaine.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Lidocaine.Approved
DihydrocodeineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dihydrocodeine.Approved, Illicit
DihydroergotamineThe metabolism of Lidocaine can be decreased when combined with Dihydroergotamine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dihydromorphine.Experimental, Illicit
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Lidocaine.Illicit
DiltiazemThe metabolism of Lidocaine can be decreased when combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dimenhydrinate.Approved
DinoprostoneThe metabolism of Dinoprostone can be decreased when combined with Lidocaine.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Lidocaine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Diphenoxylate.Approved, Illicit
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Lidocaine.Approved
DisopyramideDisopyramide may increase the arrhythmogenic activities of Lidocaine.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Lidocaine.Approved, Investigational
DofetilideLidocaine may increase the arrhythmogenic activities of Dofetilide.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
DoramectinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Doramectin.Vet Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Lidocaine.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Lidocaine.Approved, Investigational
DoxycyclineThe metabolism of Lidocaine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Lidocaine is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.Approved, Illicit
DronedaroneLidocaine may increase the arrhythmogenic activities of Dronedarone.Approved
DronedaroneThe metabolism of Lidocaine can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Drotebanol.Experimental, Illicit
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Lidocaine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dyclonine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ecgonine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Lidocaine is combined with ECGONINE METHYL ESTER.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ecopipam.Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Lidocaine.Approved
EfavirenzThe serum concentration of Lidocaine can be decreased when it is combined with Efavirenz.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Lidocaine.Approved, Investigational
EliglustatThe metabolism of Lidocaine can be decreased when combined with Eliglustat.Approved
EltrombopagThe metabolism of Eltrombopag can be decreased when combined with Lidocaine.Approved
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Lidocaine.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Lidocaine is combined with Entacapone.Approved, Investigational
EnzalutamideThe serum concentration of Lidocaine can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Lidocaine.Approved, Investigational
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Lidocaine.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Lidocaine.Approved, Investigational
ErythromycinThe metabolism of Lidocaine can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Lidocaine is combined with Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Lidocaine can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmololThe serum concentration of Lidocaine can be increased when it is combined with Esmolol.Approved
EstazolamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Estazolam.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Lidocaine.Approved, Investigational, Vet Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Lidocaine.Approved, Vet Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Lidocaine.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Lidocaine.Approved
EszopicloneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Eszopiclone.Approved
EthanolLidocaine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Lidocaine.Approved, Illicit, Withdrawn
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Lidocaine.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ethyl carbamate.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ethylmorphine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Etomidate.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Etoperidone.Approved
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Lidocaine.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Lidocaine.Approved, Investigational
EtorphineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Etorphine.Illicit, Vet Approved
EtravirineThe serum concentration of Lidocaine can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Lidocaine.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Lidocaine.Approved
EzogabineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Felbamate.Approved
FelodipineThe metabolism of Lidocaine can be decreased when combined with Felodipine.Approved, Investigational
FencamfamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fencamfamine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Lidocaine.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Lidocaine.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Lidocaine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Flibanserin.Approved
FloxuridineThe metabolism of Lidocaine can be decreased when combined with Floxuridine.Approved
FluconazoleThe metabolism of Lidocaine can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fludiazepam.Approved, Illicit
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Lidocaine.Approved
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Lidocaine.Approved, Illicit
FluorouracilThe metabolism of Lidocaine can be decreased when combined with Fluorouracil.Approved
FluoxetineThe metabolism of Lidocaine can be decreased when combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fluphenazine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Flurazepam.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fluspirilene.Approved
FlutamideThe metabolism of Flutamide can be decreased when combined with Lidocaine.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Lidocaine.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fluticasone Propionate.Approved
FluvastatinThe metabolism of Lidocaine can be decreased when combined with Fluvastatin.Approved
FluvoxamineThe metabolism of Lidocaine can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Lidocaine can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Lidocaine can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Lidocaine can be increased when combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fospropofol.Approved, Illicit
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Lidocaine.Approved, Investigational
Fusidic AcidThe serum concentration of Lidocaine can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Gabapentin.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Lidocaine is combined with gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Lidocaine is combined with Gamma Hydroxybutyric Acid.Approved, Illicit
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Lidocaine.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Lidocaine.Approved
GemfibrozilThe metabolism of Lidocaine can be decreased when combined with Gemfibrozil.Approved
GenisteinThe metabolism of Genistein can be decreased when combined with Lidocaine.Investigational
GepironeThe risk or severity of adverse effects can be increased when Lidocaine is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Glutethimide.Approved, Illicit
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Lidocaine.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Lidocaine.Withdrawn
GuanabenzThe metabolism of Guanabenz can be decreased when combined with Lidocaine.Approved
GuanfacineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Halazepam.Approved, Illicit, Withdrawn
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Lidocaine.Approved
HalothaneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Halothane.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Heroin.Approved, Illicit
HesperetinThe metabolism of Hesperetin can be decreased when combined with Lidocaine.Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Lidocaine.Approved
HyaluronidaseThe risk or severity of adverse effects can be increased when Hyaluronidase is combined with Lidocaine.Approved, Investigational
HydrocodoneLidocaine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Lidocaine.Approved, Vet Approved
HydromorphoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Hydromorphone.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Lidocaine.Approved
IbutilideLidocaine may increase the arrhythmogenic activities of Ibutilide.Approved
IdelalisibThe serum concentration of Lidocaine can be increased when it is combined with Idelalisib.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Lidocaine.Approved
ImatinibThe metabolism of Lidocaine can be decreased when combined with Imatinib.Approved
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Lidocaine.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Lidocaine.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Lidocaine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Indalpine.Investigational, Withdrawn
IndenololThe serum concentration of Lidocaine can be increased when it is combined with Indenolol.Withdrawn
IndinavirThe metabolism of Lidocaine can be decreased when combined with Indinavir.Approved
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Lidocaine.Approved, Investigational
IrbesartanThe metabolism of Lidocaine can be decreased when combined with Irbesartan.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Lidocaine.Approved, Investigational
IsavuconazoniumThe metabolism of Lidocaine can be decreased when combined with Isavuconazonium.Approved, Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Isoflurane.Approved, Vet Approved
IsoniazidThe metabolism of Lidocaine can be decreased when combined with Isoniazid.Approved
IsradipineThe metabolism of Lidocaine can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Lidocaine can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Lidocaine can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Lidocaine.Approved, Vet Approved
IxazomibThe metabolism of Ixazomib can be decreased when combined with Lidocaine.Approved
KetamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ketamine.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Lidocaine.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ketobemidone.Approved
KetoconazoleThe metabolism of Lidocaine can be decreased when combined with Ketoconazole.Approved, Investigational
LabetalolThe serum concentration of Lidocaine can be increased when it is combined with Labetalol.Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Lidocaine.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Lidocaine.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Lidocaine.Approved, Investigational
LapatinibThe metabolism of Lidocaine can be decreased when combined with Lapatinib.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Lidocaine.Approved
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Lidocaine.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Lidocaine.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Lidocaine.Approved
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Lidocaine.Approved, Investigational
LevobunololThe serum concentration of Lidocaine can be increased when it is combined with Levobunolol.Approved
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Lidocaine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Lidocaine is combined with Levodopa.Approved
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Lidocaine.Approved, Investigational
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Levomethadyl Acetate.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Lidocaine.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Levorphanol.Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Lidocaine.Approved
LithiumThe risk or severity of adverse effects can be increased when Lidocaine is combined with Lithium.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lidocaine is combined with Lofentanil.Illicit
LomefloxacinThe metabolism of Lomefloxacin can be decreased when combined with Lidocaine.Approved
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Lidocaine.Approved
LopinavirThe metabolism of Lidocaine can be decreased when combined with Lopinavir.Approved
LoratadineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Lidocaine.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Lidocaine.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Lidocaine.Approved
LovastatinThe metabolism of Lidocaine can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Loxapine.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Lidocaine is combined with Lu AA21004.Investigational
LuliconazoleThe serum concentration of Lidocaine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Lidocaine can be increased when it is combined with Lumacaftor.Approved
LumefantrineThe metabolism of Lidocaine can be decreased when combined with Lumefantrine.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Lidocaine.Approved, Investigational
LurasidoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.Approved, Vet Approved
MalathionThe metabolism of Malathion can be decreased when combined with Lidocaine.Approved, Investigational
MannitolThe serum concentration of Mannitol can be increased when it is combined with Lidocaine.Approved, Investigational
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Lidocaine.Approved
MeclizineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Medetomidine.Vet Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Lidocaine.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Melperone.Approved
MenadioneThe metabolism of Menadione can be decreased when combined with Lidocaine.Approved, Nutraceutical
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Lidocaine.Investigational, Withdrawn
MepivacaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Mepivacaine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Meprobamate.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Mesoridazine.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Metaxalone.Approved
MethadoneThe metabolism of Methadone can be decreased when combined with Lidocaine.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methadyl Acetate.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methaqualone.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methohexital.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Lidocaine.Approved
MethotrimeprazineLidocaine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Lidocaine.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methsuximide.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methylphenobarbital.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Lidocaine.Approved, Vet Approved
MetipranololThe serum concentration of Lidocaine can be increased when it is combined with Metipranolol.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Lidocaine.Approved, Investigational
MetyrosineLidocaine may increase the sedative activities of Metyrosine.Approved
MexiletineThe metabolism of Lidocaine can be decreased when combined with Mexiletine.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Lidocaine.Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Lidocaine.Approved, Illicit
MifepristoneThe serum concentration of Lidocaine can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Lidocaine is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Lidocaine.Approved
MirtazapineLidocaine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of Lidocaine can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Lidocaine.Approved, Investigational
ModafinilThe serum concentration of Lidocaine can be decreased when it is combined with Modafinil.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Molindone.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Lidocaine.Approved, Investigational
muraglitazarThe metabolism of muraglitazar can be decreased when combined with Lidocaine.Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Lidocaine.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.Approved, Investigational
NabumetoneThe metabolism of Nabumetone can be decreased when combined with Lidocaine.Approved
NadololThe serum concentration of Nadolol can be increased when it is combined with Lidocaine.Approved
NafcillinThe serum concentration of Lidocaine can be decreased when it is combined with Nafcillin.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Nalbuphine.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Lidocaine.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Lidocaine.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Lidocaine.Approved, Vet Approved
NefazodoneThe metabolism of Lidocaine can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Lidocaine can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Lidocaine can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Lidocaine can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Lidocaine can be decreased when combined with Nicardipine.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Lidocaine.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Lidocaine.Approved
NilotinibThe metabolism of Lidocaine can be decreased when combined with Nilotinib.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Lidocaine.Approved
NitrazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Nitrazepam.Approved
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Lidocaine.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Nitrous oxide.Approved, Vet Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Lidocaine.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Normethadone.Approved, Illicit
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Lidocaine.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Lidocaine.Approved, Investigational
OlaparibThe metabolism of Lidocaine can be decreased when combined with Olaparib.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Olopatadine.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Lidocaine.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Lidocaine.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Lidocaine.Approved
OpiumThe risk or severity of adverse effects can be increased when Lidocaine is combined with Opium.Approved, Illicit
OrphenadrineLidocaine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Lidocaine is combined with Osanetant.Investigational
OsimertinibThe serum concentration of Lidocaine can be increased when it is combined with Osimertinib.Approved
OxaliplatinThe metabolism of Oxaliplatin can be decreased when combined with Lidocaine.Approved, Investigational
OxazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Oxazepam.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Lidocaine is combined with Oxprenolol.Approved
OxprenololThe serum concentration of Lidocaine can be increased when it is combined with Oxprenolol.Approved
OxtriphyllineThe metabolism of Oxtriphylline can be decreased when combined with Lidocaine.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Oxybuprocaine.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Oxymorphone.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Lidocaine.Approved, Vet Approved
PalbociclibThe serum concentration of Lidocaine can be increased when it is combined with Palbociclib.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Paliperidone.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Lidocaine.Approved, Investigational
PanobinostatThe serum concentration of Lidocaine can be increased when it is combined with Panobinostat.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Lidocaine.Approved
ParaldehydeLidocaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe metabolism of Lidocaine can be decreased when combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Lidocaine.Approved
Peginterferon alfa-2bThe serum concentration of Lidocaine can be decreased when it is combined with Peginterferon alfa-2b.Approved
PenbutololThe serum concentration of Lidocaine can be increased when it is combined with Penbutolol.Approved, Investigational
PentamidineThe metabolism of Pentamidine can be decreased when combined with Lidocaine.Approved
PentazocineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Pentazocine.Approved, Vet Approved
PentobarbitalThe metabolism of Lidocaine can be increased when combined with Pentobarbital.Approved, Vet Approved
PentoxifyllineThe metabolism of Pentoxifylline can be decreased when combined with Lidocaine.Approved, Investigational
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.Approved
PerazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Lidocaine is combined with Perospirone.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Lidocaine.Approved
PethidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Pethidine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Lidocaine.Withdrawn
PhenobarbitalThe metabolism of Lidocaine can be increased when combined with Phenobarbital.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Phenoxyethanol.Approved
PhenytoinThe metabolism of Lidocaine can be increased when combined with Phenytoin.Approved, Vet Approved
PimozideThe metabolism of Pimozide can be decreased when combined with Lidocaine.Approved
PindololThe serum concentration of Lidocaine can be increased when it is combined with Pindolol.Approved
PioglitazoneThe metabolism of Lidocaine can be decreased when combined with Pioglitazone.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Pipamperone.Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Lidocaine.Approved
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Lidocaine.Investigational
PiritramideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Piritramide.Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Lidocaine.Approved
PizotifenThe risk or severity of adverse effects can be increased when Lidocaine is combined with Pizotifen.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Lidocaine.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Lidocaine.Approved
PosaconazoleThe metabolism of Lidocaine can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PractololThe serum concentration of Lidocaine can be increased when it is combined with Practolol.Approved
PramipexoleLidocaine may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Pramocaine.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Lidocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Prazepam.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Lidocaine.Approved, Vet Approved
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Lidocaine.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Lidocaine.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Lidocaine.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lidocaine.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Prilocaine.Approved
PrimaquineThe metabolism of Primaquine can be decreased when combined with Lidocaine.Approved
PrimidoneThe metabolism of Lidocaine can be increased when combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Procaine.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Prochlorperazine.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Lidocaine.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Lidocaine.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Lidocaine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Promethazine.Approved
PropafenoneThe metabolism of Propafenone can be decreased when combined with Lidocaine.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Proparacaine.Approved, Vet Approved
PropofolThe metabolism of Propofol can be decreased when combined with Lidocaine.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Propoxycaine.Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Lidocaine.Approved, Investigational
ProtriptylineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Lidocaine.Approved
PSD502The risk or severity of adverse effects can be increased when Lidocaine is combined with PSD502.Investigational
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Lidocaine.Approved
PyrimethamineThe metabolism of Lidocaine can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuazepamThe serum concentration of Lidocaine can be increased when it is combined with Quazepam.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Lidocaine.Approved
QuinidineThe metabolism of Lidocaine can be decreased when combined with Quinidine.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Lidocaine.Approved
RabeprazoleThe metabolism of Lidocaine can be decreased when combined with Rabeprazole.Approved, Investigational
RacloprideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Raclopride.Investigational
RamelteonThe metabolism of Ramelteon can be decreased when combined with Lidocaine.Approved, Investigational
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Lidocaine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Lidocaine.Approved, Investigational
RasagilineThe metabolism of Rasagiline can be decreased when combined with Lidocaine.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Lidocaine is combined with Remifentanil.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Remoxipride.Approved, Withdrawn
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Lidocaine.Approved
ResveratrolThe metabolism of Resveratrol can be decreased when combined with Lidocaine.Experimental, Investigational
RifabutinThe metabolism of Lidocaine can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Lidocaine can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Lidocaine can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Lidocaine.Approved, Investigational
RiluzoleThe metabolism of Riluzole can be decreased when combined with Lidocaine.Approved, Investigational
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Lidocaine.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ritanserin.Investigational
RitonavirThe metabolism of Lidocaine can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Lidocaine.Approved
RizatriptanThe metabolism of Rizatriptan can be decreased when combined with Lidocaine.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Lidocaine.Investigational, Withdrawn
RolapitantThe metabolism of Lidocaine can be decreased when combined with Rolapitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Lidocaine.Approved, Investigational
RomifidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Romifidine.Vet Approved
RopiniroleLidocaine may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Lidocaine.Approved
RosiglitazoneThe metabolism of Lidocaine can be decreased when combined with Rosiglitazone.Approved, Investigational
RotigotineLidocaine may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Lidocaine.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Lidocaine is combined with S-Ethylisothiourea.Experimental
Sage 547The risk or severity of adverse effects can be increased when Lidocaine is combined with Sage 547.Investigational
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Lidocaine.Approved, Vet Approved
SaquinavirSaquinavir may increase the arrhythmogenic activities of Lidocaine.Approved, Investigational
SaquinavirThe metabolism of Lidocaine can be decreased when combined with Saquinavir.Approved, Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Scopolamine.Approved
SecobarbitalThe metabolism of Lidocaine can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Lidocaine.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Lidocaine.Approved
SertindoleThe risk or severity of adverse effects can be increased when Lidocaine is combined with Sertindole.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Lidocaine.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Sevoflurane.Approved, Vet Approved
SildenafilThe metabolism of Lidocaine can be decreased when combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Lidocaine.Approved
SiltuximabThe serum concentration of Lidocaine can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Lidocaine can be increased when it is combined with Simeprevir.Approved
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Lidocaine.Approved, Investigational
Sodium NitriteThe risk or severity of adverse effects can be increased when Lidocaine is combined with Sodium Nitrite.Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.Approved
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Lidocaine.Approved
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Lidocaine.Approved, Investigational
SotalolThe serum concentration of Lidocaine can be increased when it is combined with Sotalol.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Lidocaine.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Lidocaine.Experimental
St. John's WortThe serum concentration of Lidocaine can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Lidocaine can be increased when it is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Lidocaine is combined with Sufentanil.Approved, Investigational
SulfadiazineThe metabolism of Lidocaine can be decreased when combined with Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Lidocaine can be decreased when combined with Sulfamethoxazole.Approved
SulfisoxazoleThe metabolism of Lidocaine can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Sulpiride.Approved
SuvorexantLidocaine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TacrineThe metabolism of Tacrine can be decreased when combined with Lidocaine.Withdrawn
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Lidocaine.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Lidocaine.Approved
TandospironeThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tasimelteon.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Lidocaine.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lidocaine.Approved
Technetium Tc-99m tilmanoceptLidocaine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.Approved
TedisamilLidocaine may increase the arrhythmogenic activities of Tedisamil.Investigational
TelaprevirThe metabolism of Lidocaine can be decreased when combined with Telaprevir.Approved
TelaprevirThe risk or severity of adverse effects can be increased when Telaprevir is combined with Lidocaine.Approved
TelithromycinThe metabolism of Lidocaine can be decreased when combined with Telithromycin.Approved
TemafloxacinThe metabolism of Temafloxacin can be decreased when combined with Lidocaine.Withdrawn
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Lidocaine.Approved
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Lidocaine.Approved
TenofovirThe metabolism of Lidocaine can be decreased when combined with Tenofovir.Approved, Investigational
TerbinafineThe metabolism of Lidocaine can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TeriflunomideThe serum concentration of Lidocaine can be decreased when it is combined with Teriflunomide.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tetrodotoxin.Investigational
ThalidomideLidocaine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheobromineThe metabolism of Theobromine can be decreased when combined with Lidocaine.Approved
TheophyllineThe metabolism of Lidocaine can be decreased when combined with Theophylline.Approved
ThiabendazoleThe metabolism of Thiabendazole can be decreased when combined with Lidocaine.Approved, Vet Approved
ThiamylalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Thiamylal.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Thiopental.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Lidocaine.Approved
ThiotepaThe metabolism of Lidocaine can be decreased when combined with Thiotepa.Approved
ThiothixeneThe metabolism of Thiothixene can be decreased when combined with Lidocaine.Approved
TiagabineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tiapride.Investigational
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Lidocaine.Approved
TiclopidineThe metabolism of Lidocaine can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tiletamine.Vet Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Lidocaine.Approved
TipranavirThe metabolism of Lidocaine can be decreased when combined with Tipranavir.Approved, Investigational
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Lidocaine.Approved
TocilizumabThe serum concentration of Lidocaine can be decreased when it is combined with Tocilizumab.Approved
TolbutamideThe metabolism of Lidocaine can be decreased when combined with Tolbutamide.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tolcapone.Approved, Withdrawn
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Lidocaine.Approved
TopiramateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Topiramate.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Lidocaine.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Lidocaine.Approved, Investigational
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Lidocaine.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe metabolism of Lidocaine can be decreased when combined with Tranylcypromine.Approved
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Lidocaine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Trazodone.Approved, Investigational
TriamtereneThe metabolism of Triamterene can be decreased when combined with Lidocaine.Approved
TriazolamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Triazolam.Approved
TrifluoperazineThe metabolism of Trifluoperazine can be decreased when combined with Lidocaine.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Triflupromazine.Approved, Vet Approved
TrimethoprimThe metabolism of Lidocaine can be decreased when combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Triprolidine.Approved
Uc1010The risk or severity of adverse effects can be increased when Lidocaine is combined with Uc1010.Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Lidocaine.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Lidocaine.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Lidocaine is combined with Valproic Acid.Approved, Investigational
ValsartanThe metabolism of Lidocaine can be decreased when combined with Valsartan.Approved, Investigational
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Lidocaine.Approved
VemurafenibThe serum concentration of Lidocaine can be increased when it is combined with Vemurafenib.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Lidocaine.Approved
VenlafaxineThe metabolism of Lidocaine can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Lidocaine can be decreased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Vigabatrin.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Lidocaine.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Lidocaine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Lidocaine.Approved
VoriconazoleThe metabolism of Lidocaine can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Vortioxetine.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Lidocaine.Approved
XylazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Xylazine.Vet Approved
ZafirlukastThe metabolism of Lidocaine can be decreased when combined with Zafirlukast.Approved, Investigational
ZaleplonThe risk or severity of adverse effects can be increased when Lidocaine is combined with Zaleplon.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ziconotide.Approved
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Lidocaine.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Lidocaine.Approved, Investigational, Withdrawn
ZimelidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Lidocaine can be decreased when combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Zolazepam.Vet Approved
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Lidocaine.Approved, Investigational
ZolpidemLidocaine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Zopiclone.Approved
ZotepineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Zuclopenthixol.Approved, Investigational
Food InteractionsNot Available
References
Synthesis Reference

DrugSyn.org

US2441498A
General References
  1. Khaliq W, Alam S, Puri N: Topical lidocaine for the treatment of postherpetic neuralgia. Cochrane Database Syst Rev. 2007 Apr 18;(2):CD004846. [PubMed:17443559 ]
  2. Thomson PD, Melmon KL, Richardson JA, Cohn K, Steinbrunn W, Cudihee R, Rowland M: Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans. Ann Intern Med. 1973 Apr;78(4):499-508. [PubMed:4694036 ]
  3. Geha PY, Baliki MN, Chialvo DR, Harden RN, Paice JA, Apkarian AV: Brain activity for spontaneous pain of postherpetic neuralgia and its modulation by lidocaine patch therapy. Pain. 2007 Mar;128(1-2):88-100. Epub 2006 Oct 25. [PubMed:17067740 ]
  4. Hines R, Keaney D, Moskowitz MH, Prakken S: Use of lidocaine patch 5% for chronic low back pain: a report of four cases. Pain Med. 2002 Dec;3(4):361-5. [PubMed:15099246 ]
External Links
ATC CodesC01BB01N01BB02D04AB01R02AD02S02DA01C05AD01S01HA07N01BB52
AHFS Codes
  • 24:04.04
  • 24:04.04.08
  • 52:16.00
  • 72:00.00
  • 84:08.00
PDB EntriesNot Available
FDA labelDownload (548 KB)
MSDSDownload (74.6 KB)
ADMET
Predicted ADMET featuresNot Available
Pharmacoeconomics
Manufacturers
  • Astrazeneca lp
  • Noven pharmaceuticals inc
  • Carlisle laboratories inc
  • E fougera div altana inc
  • Graham chemical co
  • Taro pharmaceuticals usa inc
  • Teikoku pharma usa inc
  • Abbott laboratories pharmaceutical products div
  • Abbott laboratories hosp products div
  • Abraxis pharmaceutical products
  • Akorn inc
  • Baxter healthcare corp anesthesia and critical care
  • Bel mar laboratories inc
  • Dell laboratories inc
  • Elkins sinn div ah robins co inc
  • Gd searle llc
  • Hospira inc
  • International medication systems ltd
  • International medication system
  • Luitpold pharmaceuticals inc
  • Miles laboratories inc
  • Watson laboratories inc
  • Wyeth ayerst laboratories
  • Baxter healthcare corp
  • B braun medical inc
  • App pharmaceuticals llc
  • Meridian medical technologies inc
  • Dentsply pharmaceutical
  • Polymedica industries inc
  • Teva pharmaceuticals usa
  • Hi tech pharmacal co inc
  • Wockhardt eu operations (swiss) ag
  • Actavis mid atlantic llc
  • Vintage pharmaceuticals llc
  • Roxane laboratories inc
  • Kendall co
  • Paco research corp
  • Anesiva inc
Packagers
Dosage forms
FormRouteStrength
SolutionIntravenous20 mg
LiquidSubarachnoid
Kit
GelTopical25 mg/mL
SolutionTopical1 %
Liquid; sprayTopical0.5 %
GelTopical0.5 %
GelTopical2.5 g/100g
KitTopical
GelOphthalmic35 mg/mL
OintmentTopical4 g/100mL
GelTopical.5 g/100mL
GelTopical.5 g/100g
GelTopical2.5 g/g
LiquidInfiltration; Subcutaneous1 %
CreamTopical5 g/100mL
LiquidEpidural1 %
OintmentTopical.05 g/g
Kit; liquidIntravenous
LiquidIntravenous
LiquidIntra-articular1 %
PatchTopical246 mg/1
OintmentTopical246 mg/1
LotionTopical4 g/100g
CreamTopical2 g/100g
ImplantIntradermal.3 %
GelTopical4.1 mg/mL
GelTopical0.7 %
LiquidTopical2 %
GelTopical5 %
CreamTopical2 %
GelTopical2 g/100g
CreamTopical2.8 g/56g
Aerosol, sprayTopical
SprayTopical10 mg/mg
SprayTopical20 mg/L
CreamTopical2.25 %
GelTopical2 g/100mL
GelTopical2.5 g/100mL
SprayTopical2 g/100mL
GelTopical0.72 %
SprayTopical.05 g/100g
SprayTopical.5 g/100g
SprayTopical200 g/L
SprayTopical2.4 %
CreamTopical.04 mg/mg
GelTopical1.0 %
GelTopical20 mg
TabletDental
Liquid; ointmentIntravenous; Topical
Kit; liquid; ointmentInfiltration; Parenteral; Subcutaneous; Topical
LiquidEpidural; Infiltration; Subcutaneous
CreamTopical4 g/100mL
CreamTopical40 mg/mL
SolutionIntra-articular; Intrabursal
SprayTopical50 mg/g
CreamTopical38.8 mg/g
KitTopical
CreamTopical5 g/100g
CreamTopical5 g/30g
SprayTopical10 mg/.08mL
Kit
LotionTopical4 g/mL
SprayTopical10 mg/100mL
Kit; ointment; solutionInfiltration; Intravenous; Topical
CreamTopical20 mg/1000mg
CreamTopical40 mg/1000mg
GelTopical40 mg/1000mg
LiquidTopical40 mg/1000mg
CreamTopical4 mg/mL
Liquid; sprayTopical
SwabTopical
SprayTopical
SprayCutaneous
GelTopical10 mg/g
SprayTopical10 mg/mL
GelTopical2 %
KitIntra-amniotic
AerosolTopical40 mg/g
GelTopical500 g/100000mg
SprayCutaneous.5 g/100g
OintmentTopical4 g/100g
CreamTopical5.0 %
GelTopical.8 g/100g
GelTopical0.8 %
CreamTopical45 mg/mL
LiquidTopical
SoapTopical
SprayTopical40 mg/g
Injection, solutionIntra-articular
Liquid; ointmentEpidural; Topical
LotionTopical.5 g/100mL
LotionTopical
Spray, meteredTopical96 mg/mL
LiquidEndotracheal40 mg
SolutionTopical40 mg/mL
Aerosol, sprayTopical.64 g/127g
Injection, solutionEpidural; Infiltration20 mg/mL
OintmentTopical35.44 g/g
OintmentTopical5 g/100g
OintmentTopical50 mg/g
PatchCutaneous140 mg/1
PatchCutaneous700 mg/1
LiquidInfiltration
CreamRectal; Topical
SolutionIntravenous
LiquidEpidural; Infiltration10 mg
LiquidIntravenous20 mg
CreamTopical30 mg/g
GelTopical20 mg/g
GelTopical30 mg/g
GelTopical40 mg/g
InjectionEpidural; Infiltration; Intracaudal10 mg/mL
InjectionInfiltration; Intravenous10 mg/mL
InjectionInfiltration; Intravenous20 mg/mL
InjectionInfiltration; Intravenous5 mg/mL
InjectionIntravenous20 mg/mL
InjectionParenteral20 mg/mL
Injection, solutionEpidural; Infiltration10 mg/mL
Injection, solutionEpidural; Infiltration; Intracaudal; Perineural10 mg/mL
Injection, solutionEpidural; Infiltration; Intracaudal; Perineural20 mg/mL
Injection, solutionInfiltration10 mg/mL
Injection, solutionInfiltration20 mg/mL
Injection, solutionInfiltration5 mg/mL
Injection, solutionInfiltration; Intravenous5 mg/mL
Injection, solutionIntravenous10 mg/mL
Injection, solutionIntravenous20 mg/mL
Injection, solutionRetrobulbar; Topical40 mg/mL
JellyTopical20 mg/mL
LiquidTopical20 mg/mL
LiquidTopical200 mL/L
LotionTopical3 g/100mL
LotionTopical5.31 mL/177mL
SolutionOral20 mg/mL
SolutionOropharyngeal20 mg/mL
SolutionTopical20 mg/mL
SprayTopical20 g/L
SolutionEpidural; Infiltration
Injection, solutionIntravenous
Injection, solutionIntravenous4 mg/mL
Injection, solutionIntravenous400 mg/100mL
Injection, solutionIntravenous8 mg/mL
Injection, solutionIntravenous800 mg/100mL
InjectionInfiltration
Injection, solutionDental; Infiltration
Injection, solutionEpidural
Injection, solutionInfiltration
CreamRectal
GelRectal
LiquidInfiltration20 mg
SolutionInfiltration10 mg
LiquidInfiltration2 %
SolutionInfiltration20 mg
SprayTopical1 %
GelOral2 g/100mL
OintmentTopical5 g
CreamTopical39.2 mg/mL
SolutionOral; Topical20 mg/mL
SprayTopical20 mg/mL
GelTopical7.2 g/240g
SprayTopical4.6 g/115g
CreamTopical10 g/100g
SolutionTopical4 %
LiquidTopical10 mg
JellyTopical2 %
OintmentTopical5 %
LiquidBuccal2 %
PatchCutaneous700 mg/12h
LiquidCutaneous700 mg/1000mg
PatchTopical22.7 mg/.24mg
PatchTopical25.3 mg/.24mg
PatchTopical25.8 mg/.24mg
PatchTopical28.1 mg/.24mg
PatchTopical29 mg/.24mg
PatchTopical21.5 mg/.24mg
LiquidAuricular (otic)
PatchTopical
PatchTransdermal
CreamTopical32.5 mg/g
CreamTopical37.5 mg/g
CreamTopical39.5 mg/g
SprayTopical10 mg/.1mL
CreamTopical40 mg/g
CreamTopical50 mg/g
LiquidSubcutaneous1 %
Spray, meteredTopical9.6 mg/100mL
CreamTopical4 %
CreamTopical5 %
AerosolTopical
GelTopical.04 g/g
Solution / dropsOphthalmic; Topical
Liquid; ointmentSubcutaneous; Topical
LiquidInfiltration; Intraspinal; Subcutaneous1 %
SolutionIntramuscular; Intravenous
CreamTopical50 mg/mL
Spray, meteredTopical
SprayTopical24.64 mg/mL
CreamTopical5 mg/g
CreamTopical5 mg/30g
SprayTopical.04 mg/mg
SolutionTopical
StickTopical
LiquidDental; Subcutaneous
Injection, solutionSubcutaneous
LiquidSubcutaneous
GelPeriodontal
SuspensionAuricular (otic)
LotionTopical40 mg/4mL
CreamTopical4 g/100g
GelTopical7.13 mg/mL
LiquidInfiltration; Subcutaneous; Topical
GelTopical2 mg/g
LiquidIntravenous1 %
Kit; ointment; solutionInfiltration; Subcutaneous; Topical
KitInfiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical
LiquidEpidural; Intravenous
CreamTopical
LiquidDental2 %
Solution / dropsAuricular (otic)
SprayTopical2.6 %
SprayTopical4 %
SolutionTopical40 mg
CreamTopical400 mg/mg
OintmentTopical.005 mg/g
Spray, meteredTopical9.6 g/100mL
SprayTopical10 g/100g
PackingDental
KitEpidural; Infiltration
KitEpidural; Infiltration; Intra-articular; Intramuscular; Topical
KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue
CreamTopical.05 g/g
ClothTopical
GelTopical20 mg/mL
LiquidTopical40 mg/mL
GelTopical4 g/100g
GelTopical4 %
SprayTopical2 %
SolutionTopical2 %
PatchPercutaneous; Topical; Transdermal560 mg/1
SprayTopical1.1 g/12g
GelTopical2.0 %
GelTopical40 mg/mL
GelTopical1 %
SprayTopical5 mg/g
AerosolTopical0.5 %
LotionTopical0.5 %
SprayTopical4 g/100mL
GelTopical.057 mg/mL
GelTopical0.50 %
CreamTopical.5 g/100g
KitInfiltration; Topical
LiquidParenteral; Topical
LiquidInfiltration; Subcutaneous
KitInfiltration1 %
Spray, meteredTopical9.6 %
SwabTopical1 %
PatchCutaneous
OintmentTopical
LiquidIntrathoracic; Subcutaneous1 %
GelTopical5 g/100g
SprayTopical2.5 g/100mL
GelTopical2.5 %
GelTopical
CreamTopical1 %
SolutionTopical0.5 %
SprayTopical0.5 %
CreamTopical2 g/mL
CreamTopical4 g/mL
InjectionInfiltration10 mg/mL
Injection, solutionEpidural; Infiltration; Intracaudal; Perineural
Injection, solutionInfiltration; Perineural
Injection, solutionInfiltration; Perineural10 mg/mL
Injection, solutionInfiltration; Perineural20 mg/mL
Injection, solutionInfiltration; Perineural5 mg/mL
JellyTopical.5 mg/18mL
LiquidIntraspinal
LiquidInfiltration5 mg
SolutionInfiltration5 mg
SolutionEpidural15 mg
LiquidInfiltration10 mg
SolutionInfiltration
SolutionEpidural20 mg
JellyUrethral20 mg
LiquidEpidural
LiquidSubarachnoid50 mg
SolutionEpidural; Infiltration17.3 mg
SolutionOral100 mg
JellyTopical20 mg
Injection, solutionEpidural; Infiltration; Intracaudal; Perineural15 mg/mL
LiquidIntraspinal; Percutaneous1 %
LiquidPercutaneous1 %
LiquidInfiltration1 %
AerosolOral; Topical
SprayTopical40 mg
LiquidTopical50 mg
LiquidOral; Topical20 mg
SolutionRetrobulbar; Topical40 mg/mL
LiquidEpidural; Intracaudal20 mg
LiquidIntravenous100 mg
LiquidIntravenous200 mg
Aerosol, metered; sprayTopical
LiquidTopical2.5 %
SolutionTopical4.0 %
PowderIntradermal.5 mg/1
Prices
Unit descriptionCostUnit
Rocephin 10 gm vial478.32USD each
Lidocaine HCl 3% Lotion 177ml Bottle230.3USD bottle
Rocephin 2 gm vial97.5USD each
Rocephin 1 gm vial62.02USD each
EMLA 2.5-2.5% Cream 30 gm Tube58.4USD tube
Lidocaine-Prilocaine 2.5-2.5% Cream 30 gm Tube47.79USD tube
Lidocaine HCl 2% Gel 10ml Syringe17.99USD syringe
Lidocaine HCl 2% Gel 30ml Tube17.99USD tube
Lidocaine HCl 4% Solution 50ml Bottle16.99USD bottle
Lidocaine Viscous 2% Solution 100ml Bottle13.99USD bottle
Lidocaine hcl 1% syringe9.76USD ml
Lidocaine HCl 4% Solution 4ml Bottle9.42USD bottle
Lidoderm 1 Box = 30 Patches8.03USD patch
Akten 3.5% drops7.5USD ml
Lidocaine 5% in d7.5w ampul3.06USD ml
Lidocaine 3% cream2.91USD g
Lidamantle 3% cream2.03USD g
Zilactin-l cold sore liquid0.99USD ml
Xylocaine 2% jelly0.68USD ml
Lidocaine hcl 10% vial0.55USD ml
Xylocaine 5% ointment0.42USD g
Xylocaine Jelly 2 % Jelly0.41USD g
Xylocaine 2% Solution0.34USD ml
Xylocaine 5 % Ointment0.29USD g
Lidocaine HCl 1% Solution0.24USD ml
Lidocaine hcl powder0.24USD g
Lidocaine base powder0.22USD g
Lidocaine hcl 4% solution0.18USD ml
Xylocaine 0.5% vial0.18USD ml
Lidodan 5 % Ointment0.16USD g
Xylocaine Viscous 2 % Liquid0.1USD ml
Lidocaine hcl 0.5% vial0.08USD ml
Solarcaine aerosol0.06USD g
Lidodan Viscous 2 % Liquid0.06USD ml
Lidocaine 2% viscous solution0.03USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5234957 No1994-02-272011-02-27Us
US5658583 No1995-07-282015-07-28Us
US5827529 No1995-10-272015-10-27Us
US5899880 No1996-05-042016-05-04Us
US5919479 No1995-07-282015-07-28Us
US6004286 No1997-03-172017-03-17Us
US6031007 No1997-04-012017-04-01Us
US6306431 No1995-07-282015-07-28Us
US6465006 No1995-07-282015-07-28Us
US6465709 No2000-07-072020-07-07Us
US6528086 No1999-09-282019-09-28Us
US6546281 No1995-07-282015-07-28Us
US6629968 No2000-06-302020-06-30Us
US6635045 No2001-06-292021-06-29Us
US6780426 No1995-07-282015-07-28Us
US6881200 No1996-06-112016-06-11Us
US8540665 No2009-10-222029-10-22Us
US8759401 No2006-07-242026-07-24Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point68.5 °CPhysProp
boiling point159-160 °C at 2.00E+00 mm HgPhysProp
water solubility4100 mg/L (at 30 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP2.44AVDEEF,A (1997)
logS-1.76ADME Research, USCD
Caco2 permeability-4.21ADME Research, USCD
pKa8.01SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.593 mg/mLALOGPS
logP1.81ALOGPS
logP2.84ChemAxon
logS-2.6ALOGPS
pKa (Strongest Acidic)13.78ChemAxon
pKa (Strongest Basic)7.75ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area32.34 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity73.93 m3·mol-1ChemAxon
Polarizability27.77 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (7.18 KB)
Spectra
Spectrum TypeDescriptionSplash Key
MSMass Spectrum (Electron Ionization)splash10-000i-9000000000-38a47958df650b972703View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acid amides
Alternative Parents
Substituents
  • Alpha-amino acid amide
  • N-arylamide
  • Benzenoid
  • Monocyclic benzene moiety
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity
Specific Function:
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
Gene Name:
SCN10A
Uniprot ID:
Q9Y5Y9
Molecular Weight:
220623.605 Da
References
  1. Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mould J, Drinkwater R, Baker MD, Abrahamsen B, Wood JN, Adams DJ, Christie MJ, Lewis RJ: muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):17030-5. Epub 2006 Oct 31. [PubMed:17077153 ]
  2. Muroi Y, Chanda B: Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol. 2009 Jan;133(1):1-15. doi: 10.1085/jgp.200810103. Epub 2008 Dec 15. [PubMed:19088384 ]
  3. Karoly R, Lenkey N, Juhasz AO, Vizi ES, Mike A: Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. PLoS Comput Biol. 2010 Jun 17;6(6):e1000818. doi: 10.1371/journal.pcbi.1000818. [PubMed:20585544 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity
Specific Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, es...
Gene Name:
SCN9A
Uniprot ID:
Q15858
Molecular Weight:
226370.175 Da
References
  1. Sheets PL, Jackson JO 2nd, Waxman SG, Dib-Hajj SD, Cummins TR: A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity. J Physiol. 2007 Jun 15;581(Pt 3):1019-31. Epub 2007 Apr 12. [PubMed:17430993 ]
  2. Muroi Y, Chanda B: Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol. 2009 Jan;133(1):1-15. doi: 10.1085/jgp.200810103. Epub 2008 Dec 15. [PubMed:19088384 ]
  3. Karoly R, Lenkey N, Juhasz AO, Vizi ES, Mike A: Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. PLoS Comput Biol. 2010 Jun 17;6(6):e1000818. doi: 10.1371/journal.pcbi.1000818. [PubMed:20585544 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity involved in sa node cell action potential
Specific Function:
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is respon...
Gene Name:
SCN5A
Uniprot ID:
Q14524
Molecular Weight:
226937.475 Da
References
  1. Itoh H, Tsuji K, Sakaguchi T, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Ashihara T, Ito M, Horie M, Imoto K: A paradoxical effect of lidocaine for the N406S mutation of SCN5A associated with Brugada syndrome. Int J Cardiol. 2007 Oct 18;121(3):239-48. Epub 2007 Apr 18. [PubMed:17445919 ]
  2. Fedida D, Orth PM, Hesketh JC, Ezrin AM: The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers. J Cardiovasc Electrophysiol. 2006 May;17 Suppl 1:S71-S78. [PubMed:16686685 ]
  3. Wallace CH, Baczko I, Jones L, Fercho M, Light PE: Inhibition of cardiac voltage-gated sodium channels by grape polyphenols. Br J Pharmacol. 2006 Nov;149(6):657-65. Epub 2006 Oct 3. [PubMed:17016511 ]
  4. Cerne A, Bergh C, Borg K, Ek I, Gejervall AL, Hillensjo T, Olofsson JI, Stener-Victorin E, Wood M, Westlander G: Pre-ovarian block versus paracervical block for oocyte retrieval. Hum Reprod. 2006 Nov;21(11):2916-21. Epub 2006 Jul 13. [PubMed:16840798 ]
  5. Muroi Y, Chanda B: Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol. 2009 Jan;133(1):1-15. doi: 10.1085/jgp.200810103. Epub 2008 Dec 15. [PubMed:19088384 ]
  6. Karoly R, Lenkey N, Juhasz AO, Vizi ES, Mike A: Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. PLoS Comput Biol. 2010 Jun 17;6(6):e1000818. doi: 10.1371/journal.pcbi.1000818. [PubMed:20585544 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Ubiquitin protein ligase binding
Specific Function:
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on ke...
Gene Name:
EGFR
Uniprot ID:
P00533
Molecular Weight:
134276.185 Da
References
  1. Sakaguchi M, Kuroda Y, Hirose M: The antiproliferative effect of lidocaine on human tongue cancer cells with inhibition of the activity of epidermal growth factor receptor. Anesth Analg. 2006 Apr;102(4):1103-7. [PubMed:16551906 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT: Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65. [PubMed:10901707 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. [PubMed:19754423 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT: Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65. [PubMed:10901707 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP2C18
Uniprot ID:
P33260
Molecular Weight:
55710.075 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Gene Name:
SLC22A5
Uniprot ID:
O76082
Molecular Weight:
62751.08 Da
References
  1. Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. [PubMed:11160873 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol. 2001 Dec;14(12):1596-603. [PubMed:11743742 ]
  2. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103 ]
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Drug created on June 13, 2005 07:24 / Updated on December 09, 2016 02:39