Sulfacetamide

Identification

Name
Sulfacetamide
Accession Number
DB00634  (APRD00452)
Type
Small Molecule
Groups
Approved
Description

An anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections. [PubChem]

Structure
Thumb
Synonyms
  • Acetosulfamine
  • N-((P-Aminophenyl)sulfonyl)acetamide
  • N-(P-Aminobenzenesulfonyl)acetamide
  • N-[(P-Aminophenyl)sulfonyl]acetamide
  • N-Acetyl-4-aminobenzenesulfonamide
  • N-Acetylsulfanilamide
  • N-Sulfanilylacetamide
  • N-Sulphanilylacetamide
  • N'-acetylsulfanilamide
  • N(1)-Acetyl-4-aminophenylsulfonamide
  • N(1)-Acetylsulfanilamide
  • P-Aminobenzenesulfonacetamide
  • P-Aminobenzenesulfonoacetamide
  • Sulfacetamid
  • Sulfacetamida
  • Sulfacétamide
  • Sulfacetamidum
  • Sulfanilazetamid
  • Sulphacetamide
  • Sulphacetamidum
External IDs
NSC-63871
Product Ingredients
IngredientUNIICASInChI Key
Sulfacetamide sodium4NRT660KJQ 6209-17-2IHCDKJZZFOUARO-UHFFFAOYSA-M
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Balsulph Oph Liq 10.0%Solution / drops100 mgOphthalmicBausch & Lomb Inc1989-12-311996-09-09Canada
Balsulph Oph Ont 10.0%Ointment10 %OphthalmicBausch & Lomb Inc1989-12-311997-09-12Canada
Bleph 10 DpsSolution / drops10 %OphthalmicAllergan1964-12-312011-08-04Canada
Bleph-10Solution / drops100 mg/mLOphthalmicAllergan1971-06-01Not applicableUs
Cetamide Ont 10%Ointment10 %OphthalmicAlcon, Inc.1972-12-312009-04-24Canada
KlaronLotion10 mg/mLTopicalPhysicians Total Care, Inc.2005-09-01Not applicableUs
KlaronLotion100 mg/mLTopicalValeant Pharmaceuticals North America1996-12-23Not applicableUs
Odan-sulfacetamideSolution10 %OphthalmicOdan Laboratories Ltd1985-12-31Not applicableCanada
Ophtho-sulf Liq 10%Liquid10 %OphthalmicAltimed Pharma Inc.1986-12-311997-08-14Canada
PMS-sulfacetamide Sod Oph Soln 30%Solution / drops300 mgOphthalmicPharmascience Inc1991-12-312016-10-28Canada
PMS-sulfacetamide Sodium Liq 10%Liquid10 %OphthalmicPharmascience Inc1991-12-312016-10-28Canada
Sodium Sulamyd 10%Solution / drops100 mgOphthalmicSandoz Canada Incorporated1951-12-31Not applicableCanada
Sodium Sulamyd Oph Dps 30%Solution / drops300 mgOphthalmicSchering Plough1951-12-312001-07-18Canada
Sodium Sulamyd Oph Ont 10%Ointment10 %OphthalmicSchering Plough1951-12-312001-07-18Canada
Sodium SulfacetamideLotion100 mg/mLTopicalPrasco, Laboratories1996-12-232016-01-30Us
Sodium sulfacetamideLotion100 mg/mLTopicalOceanside Pharmaceuticals2015-12-18Not applicableUs
SulfacetamideSolution10 %OphthalmicEberth Pharmaceuticals Inc1994-12-31Not applicableCanada
Sulfex 10%Liquid10 %OphthalmicLaboratoires Charton Laboratories1982-12-312000-09-01Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
SulfacetamideSolution / drops100 mg/mLOphthalmicPacific Pharma2015-02-06Not applicableUs
Sulfacetamide SodiumSolution / drops100 mg/mLOphthalmicPreferreed Pharmaceuticals Inc.2012-02-28Not applicableUs
Sulfacetamide SodiumSuspension100 mg/mLTopicalE. Fougera & CO., A division of Fougera Pharmaceuticals Inc.2006-11-17Not applicableUs
Sulfacetamide SodiumOintment100 mg/gOphthalmicFera Pharmaceuticals2012-03-012016-11-16Us
Sulfacetamide SodiumSolution100 mg/mLOphthalmicH.J. Harkins Company2003-03-25Not applicableUs
Sulfacetamide SodiumSolution100 mg/mLOphthalmicNu Care Pharmaceuticals,inc.2003-03-25Not applicableUs
Sulfacetamide SodiumSolution / drops100 mg/mLOphthalmicRemedy Repack2013-06-132017-01-11Us
Sulfacetamide SodiumSolution / drops100 mg/mLOphthalmicDirectrx2014-01-01Not applicableUs
Sulfacetamide SodiumSolution / drops100 mg/mLOphthalmicStat Rx USA1988-10-18Not applicableUs
Sulfacetamide SodiumSolution100 mg/mLOphthalmicRebel Distributors1988-10-18Not applicableUs
Sulfacetamide SodiumSolution / drops100 mg/mLOphthalmicCentral Texas Community Health Centers1994-12-28Not applicableUs
Sulfacetamide SodiumSolution / drops100 mg/mLOphthalmicA S Medication Solutions2004-07-012017-06-20Us
Sulfacetamide SodiumSolution / drops100 mg/mLOphthalmicA S Medication Solutions1994-12-28Not applicableUs
Sulfacetamide SodiumSolution / drops100 mg/mLOphthalmicA S Medication Solutions2014-09-112017-06-20Us
Sulfacetamide SodiumOintment100 mg/gOphthalmicPaddock Laboratories, Inc.2014-08-13Not applicableUs
Sulfacetamide SodiumSolution / drops100 mg/mLOphthalmicLake Erie Medical Dba Quality Care Produts Llc1994-12-28Not applicableUs
Sulfacetamide SodiumSolution / drops100 mg/mLOphthalmicAkorn2014-09-11Not applicableUs
Sulfacetamide SodiumSolution100 mg/mLOphthalmicFalcon Pharmaceuticals2003-03-25Not applicableUs
Sulfacetamide SodiumSolution / drops100 mg/mLOphthalmicBauch & Lomb Incorporated1994-12-28Not applicableUs
Sulfacetamide SodiumLotion100 mg/mLTopicalPerrigo New York Inc.2012-10-17Not applicableUs
Sulfacetamide SodiumSuspension100 mg/mLTopicalTaro Pharmaceuticals U.S.A., Inc.2009-05-20Not applicableUs
Sulfacetamide SodiumSuspension100 mg/mLTopicalPhysicians Total Care, Inc.2011-01-19Not applicableUs
Sulfacetamide SodiumSolution100 mg/mLOphthalmicA S Medication Solutions2003-03-252017-06-20Us
Sulfacetamide SodiumSolution / drops100 mg/mLOphthalmicMajor2004-07-01Not applicableUs
Sulfacetamide SodiumSolution / drops300 mg/mLOphthalmicAkorn2014-09-11Not applicableUs
Sulfacetamide SodiumSolution100 mg/mLOphthalmicKeltman Pharmaceuticals Inc.2010-01-10Not applicableUs
Approved Over the Counter Products
Not Available
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Exact-Rx Sodium Sulfacetamide Wash 10%Liquid100 mg/mLTopicalExact Rx, Inc.2011-08-01Not applicableUs
Exact-Rx Sodium Sulfacetamide Wash 10%Liquid100 mg/mLTopicalExact Rx, Inc.2011-08-01Not applicableUs
OvaceLiquid100 mg/mLTopicalMission Pharmacal2011-09-15Not applicableUs
Ovace PlusAerosol, foam98 mg/gTopicalMission Pharmacal2010-07-15Not applicableUs
OVACE PlusLiquid100 mg/mLTopicalMission Pharmacal2011-09-15Not applicableUs
OVACE PlusShampoo100 mg/mLTopicalMission Pharmacal2011-09-15Not applicableUs
Ovace PlusLiquid100 mg/mLTopicalMission Pharmacal2011-09-07Not applicableUs
Ovace PlusLotion98 mg/gTopicalMission Pharmacal2011-09-15Not applicableUs
OvacePlus PlusCream100 mg/gTopicalMission Pharmacal2011-09-15Not applicableUs
Perrigo Seb PrevGel100 mg/gTopicalPerrigo New York Inc.2008-08-192017-01-18Us
Perrigo Seb PrevCream100 mg/gTopicalPerrigo New York Inc.2008-08-072017-01-18Us
Seb Prev WashLiquid100 mg/.95mLTopicalPerrigo New York Inc.2008-07-25Not applicableUs
Sodium SulfacetamideSwab100 mg/mLTopicalExact Rx, Inc.2011-08-012017-08-24Us
Sodium SulfacetamideShampoo100 mg/mLTopicalBiocomp Pharma, Inc.2011-09-15Not applicableUs
Sodium SulfacetamideSolution100 mg/gTopicalE. FOUGERA & CO., A division of Nycomed US Inc.2010-03-12Not applicableUs
Sodium SulfacetamideLiquid100 mg/mLTopicalAUSTIN PHARMACEUTICALS, LLC2011-09-152016-12-06Us
Sodium SulfacetamideLiquid100 mg/mLTopicalBiocomp Pharma, Inc.2013-01-07Not applicableUs
Sodium SulfacetamideLiquid100 mg/mLTopicalBiocomp Pharma, Inc.2011-09-07Not applicableUs
Sodium SulfacetamideLiquid100 mg/mLTopicalAcella Pharmaceuticals, LLC2010-12-14Not applicableUs
Sodium SulfacetamideLiquid100 mg/mLTopicalExact Rx, Inc.2011-08-01Not applicableUs
Sodium SulfacetamideGel100 mg/mLTopicalAcella Pharmaceuticals, LLC2010-12-14Not applicableUs
Sulfacetamide SodiumLiquid100 mg/mLTopicalBiocomp Pharma, Inc.2011-09-15Not applicableUs
International/Other Brands
Acetopt (Sigma Pharma) / Albucid (Allergan) / Anginamide (Medgenix) / Antebor (Kela) / Apisulfa (Amman) / Blef-10 (Allergan) / Bleph (Allergan) / Cetamide (Alcon) / Cetazin (Sigmapharm) / Oftasul (Dr. Collado) / Optal (Olan-Kemed) / Ovace / Riacetamid (Riyadh Pharma) / Sulfacil (Farmak) / Sulphacalyre (Wallace) / Unisulf (Roster)
Brand mixtures
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
AvarAerosol, foamTopicalMission Pharmacal2010-07-15Not applicableUs
Avar Cleansing PadsClothTopicalMission Pharmacal2011-09-15Not applicableUs
Avar LSAerosol, foamTopicalMission Pharmacal2010-07-15Not applicableUs
Avar LS Cleansing PadsClothTopicalMission Pharmacal2011-09-15Not applicableUs
Avar-eCreamTopicalMission Pharmacal2011-09-15Not applicableUs
Avar-e GreenCreamTopicalMission Pharmacal2011-09-15Not applicableUs
Avar-e LSCreamTopicalMission Pharmacal2011-09-15Not applicableUs
BlephamideOintmentOphthalmicAllergan1987-01-01Not applicableUs
Blephamide Oph OntOintmentOphthalmicAllergan1974-12-31Not applicableCanada
Blephamide Opht SuspensionSolution / dropsOphthalmicAllergan1989-12-31Not applicableCanada
BP Cleansing WashLiquidTopicalAcella Pharmaceuticals, LLC2008-02-08Not applicableUs
CleniaCreamTopicalUpsher Smith Laboratories2009-09-01Not applicableUs
Dioptimyd OintmentOintmentOphthalmic; TopicalDioptic Pharmaceuticals Inc1994-12-31Not applicableCanada
Exact-Rx SODIUM SULFACETAMIDE and SULFER 10%/5% CleanserLotionTopicalExact Rx, Inc.2011-08-012017-02-07Us
Metimyd Oph SusSuspensionOphthalmicSchering Plough1956-12-311999-07-22Canada
Odan-cideSolutionOphthalmicOdan Laboratories Ltd1985-12-31Not applicableCanada
Perrigo Sodium Sulfacetamide and SulfurLotionTopicalPerrigo New York Inc.2008-09-152017-01-24Us
PlexionCreamTopicalBrava2005-09-01Not applicableUs
Prascion CleanserSoapTopicalPrasco, Laboratories2011-08-052016-10-25Us
Prascion FCClothTopicalPrasco, Laboratories2011-08-082016-10-25Us
Prascion RACreamTopicalPrasco, Laboratories2010-12-222016-10-25Us
Prednisolone/sulfacetamideSuspensionOphthalmicEberth Pharmaceuticals Inc1994-12-31Not applicableCanada
RosanilSolutionTopicalGalderma2003-01-31Not applicableUs
RosulaClothTopicalAvion Pharmaceuticals, Llc2015-03-13Not applicableUs
Rosula WashLiquidTopicalAvion Pharmaceuticals, Llc2015-02-10Not applicableUs
Sodium Sulfacetamide - Sulfur Cleansing PadsSwabTopicalAcella Pharmaceuticals, LLC2010-09-16Not applicableUs
Sodium Sulfacetamide - Sulfur WashLiquidTopicalAcella Pharmaceuticals, LLC2010-09-16Not applicableUs
Sodium Sulfacetamide 10 and Sulfur 5SolutionTopicalPerrigo New York Inc.2008-06-062017-01-18Us
Sodium Sulfacetamide 10 Sulfur 2 CleanserSolutionTopicalAcella Pharmaceuticals, LLC2008-02-08Not applicableUs
Sodium Sulfacetamide 10 Sulfur 2 creamCreamTopicalAcella Pharmaceuticals, LLC2008-02-08Not applicableUs
Sodium Sulfacetamide 10 Sulfur 5ClothTopicalAcella Pharmaceuticals, LLC2011-02-08Not applicableUs
Sodium Sulfacetamide 10 Sulfur 5 CleanserRinseTopicalAcella Pharmaceuticals, LLC2010-09-16Not applicableUs
Sodium Sulfacetamide 9 Sulfur 4.5 WashRinseTopicalAcella Pharmaceuticals, LLC2011-07-20Not applicableUs
Sodium Sulfacetamide 9.8% and Sulfur 4.8%LotionTopicalRosemar Labs, LLC2005-09-01Not applicableUs
Sodium Sulfacetamide 9.8% and Sulfur 4.8% CleanserSolutionTopicalBurel Pharmaceuticals, Llc2016-03-142016-10-13Us
Sodium Sulfacetamide 9.8% and Sulfur 4.8% CreamCreamTopicalRosemar Labs, LLC2005-09-01Not applicableUs
Sodium Sulfacetamide 9.8%, Sulfur 4.8%SolutionTopicalBi Coastal Pharma International Llc2017-03-27Not applicableUs
Sodium Sulfacetamide and SulfurSolutionTopicalSeton Pharmaceuticals2011-05-27Not applicableUs
Sodium Sulfacetamide and Sulfur 10 Percent and 2 Percent CleanserSoapTopicalMethod Pharmaceuticals2015-02-012015-12-29Us
Sodium Sulfacetamide and Sulfur 10 Percent and 5 Percent CleanserSoapTopicalMethod Pharmaceuticals2015-02-012015-12-29Us
Sodium Sulfacetamide and Sulfur CleanserCreamTopicalBi Coastal Pharma International Llc2011-06-01Not applicableUs
Sodium Sulfacetamide and Sulfur External CreamCreamTopicalCameron Pharmaceuticals2015-10-262016-10-13Us
Sodium Sulfacetamide and Sulfur External LiquidLiquidTopicalCameron Pharmaceuticals2015-10-262016-10-13Us
SODIUM SULFACETAMIDE and SULFUR Topical SuspensionSuspensionTopicalRochester Pharmaceuticals2013-11-042015-12-29Us
SODIUM SULFACETAMIDE and SULFUR WashLiquidTopicalAcella Pharmaceuticals, LLC2008-02-08Not applicableUs
Sodium Sulfacetamide, SulfurCreamTopicalAcella Pharmaceuticals, LLC2011-07-27Not applicableUs
Sulfacet R LotionLotionTopicalRhone Poulenc Rorer1993-12-311999-08-11Canada
Sulfacet-RLotionTopicalValeant Canada Lp Valeant Canada S.E.C.1998-11-092016-07-08Canada
Sulfacetamide Sodium and Prednisolone Sodium PhosphateSolutionOphthalmicRebel Distributors1995-12-29Not applicableUs
Sulfacetamide Sodium and SulfurCreamTopicalBi Coastal Pharma International Llc2011-06-01Not applicableUs
Sulfacetamide Sodium, SulfurLotionTopicalTrinity Pharmaceuticals, LLC2013-07-01Not applicableUs
SulfaCleanse 8/4LotionTopicalPru Gen Pharmaceuticals2011-05-01Not applicableUs
SulfixSuspensionTopicalJourney Medical Corporation2016-03-012016-10-13Us
Sultrin Triple Sulfa CrmCreamVaginalOrtho Pharmaceutical, Division Of Janssen Ortho Inc.1946-12-311999-04-14Canada
SumadanKitMedimetriks Pharmaceuticals2011-08-01Not applicableUs
Sumadan WashCreamTopicalMedimetriks Pharmaceuticals2011-07-10Not applicableUs
Sumadan XltKitMedimetriks Pharmaceuticals2013-12-01Not applicableUs
Sumaxin Cleansing PadsClothTopicalMedimetriks Pharmaceuticals2009-01-01Not applicableUs
Sumaxin CPKitMedimetriks Pharmaceuticals2011-08-01Not applicableUs
Sumaxin TSLotionTopicalMedimetriks Pharmaceuticals2010-09-02Not applicableUs
Vasocidin Ophthalmic SolutionLiquidOphthalmicIolab Pharmaceuticals1992-12-311996-09-09Canada
Vasosulf Oph SolnSolution / dropsOphthalmicIolab Pharmaceuticals1988-12-311996-09-09Canada
Virti-SULFCreamTopicalVirtus Pharmaceuticals2012-09-12Not applicableUs
Zencia WashLotionTopicalStratus Pharmaceuticals2010-08-10Not applicableUs
Categories
UNII
4965G3J0F5
CAS number
144-80-9
Weight
Average: 214.242
Monoisotopic: 214.041212886
Chemical Formula
C8H10N2O3S
InChI Key
SKIVFJLNDNKQPD-UHFFFAOYSA-N
InChI
InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
IUPAC Name
N-(4-aminobenzenesulfonyl)acetamide
SMILES
CC(=O)NS(=O)(=O)C1=CC=C(N)C=C1

Pharmacology

Indication

For the treatment of bacterial vaginitis, keratitis, acute conjunctivitis, and blepharitis.

Structured Indications
Pharmacodynamics

Sulfacetamide is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Mechanism of action

Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), an essential component for bacterial growth (according to the Woods-Fildes theory). The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

TargetActionsOrganism
ADihydropteroate synthase
inhibitor
Escherichia coli (strain K12)
ADihydropteroate synthase type-1
inhibitor
Escherichia coli
AFolic acid synthesis protein FOL1
inhibitor
Baker's yeast
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life

7-12.8 hours

Clearance
Not Available
Toxicity

Oral LD50 Mouse : 16500 mg/kg. Side effects include moderate to severe erythema (redness) and moderate edema (raised kin), nausea, vomiting, headache, dizziness, and tiredness. Higher exposure causes unconsciousness.

Affected organisms
  • Enteric bacteria and other eubacteria
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfacetamide.Approved
MecamylamineThe risk or severity of adverse effects can be increased when Sulfacetamide is combined with Mecamylamine.Approved
Food Interactions
Not Available

References

Synthesis Reference
Not Available
General References
  1. Hull CA, Johnson SM: A double-blind comparative study of sodium sulfacetamide lotion 10% versus selenium sulfide lotion 2.5% in the treatment of pityriasis (tinea) versicolor. Cutis. 2004 Jun;73(6):425-9. [PubMed:15224788 ]
  2. Del Rosso JQ: Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium sulfacetamide and sulfur formulations. Cutis. 2004 Jan;73(1 Suppl):29-33. [PubMed:14959943 ]
  3. Roth HW, Leimbeck R, Sonnenschein B, Anger CB, Weber S: [The effective antibacterial spectrum of sulfacetamide]. Klin Monbl Augenheilkd. 1992 Mar;200(3):182-6. [PubMed:1578876 ]
External Links
Human Metabolome Database
HMDB14772
KEGG Drug
D05947
PubChem Compound
5320
PubChem Substance
46504544
ChemSpider
5129
BindingDB
50316126
ChEBI
63845
ChEMBL
CHEMBL455
Therapeutic Targets Database
DAP001191
PharmGKB
PA451536
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Sulfacetamide
ATC Codes
S01AB04 — SulfacetamideG01AE10 — Combinations of sulfonamidesD10AF06 — Sulfacetamide
AHFS Codes
  • 52:04.04
PDB Entries
FDA label
Download (455 KB)
MSDS
Download (72.7 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingTreatmentOsteomyelitis1
4CompletedTreatmentMeibomian Gland Dysfunction (MGD)1

Pharmacoeconomics

Manufacturers
  • Sanofi aventis us llc
  • Altana inc
  • Perrigo co tennessee inc
  • Taro pharmaceuticals usa inc
  • Allergan pharmaceutical
  • Alcon laboratories inc
  • Schering corp sub schering plough corp
  • Pharmafair inc
  • Allergan
  • Miza pharmaceuticals usa inc
  • Akorn inc
  • Sola barnes hind
  • Novartis pharmaceuticals corp
  • Optopics laboratories corp
  • Alcon inc
  • Alcon universal ltd
  • Bausch and lomb pharmaceuticals inc
  • Bausch and lomb inc
Packagers
Dosage forms
FormRouteStrength
Aerosol, foamTopical
Solution / dropsOphthalmic10 %
OintmentOphthalmic
Suspension / dropsOphthalmic
Solution / dropsOphthalmic
LiquidTopical
OintmentOphthalmic10 %
CreamTopical
OintmentOphthalmic; Topical
LotionTopical10 mg/mL
SuspensionOphthalmic
SolutionOphthalmic10 %
Aerosol, foamTopical98 mg/g
LotionTopical98 mg/g
CreamTopical100 mg/g
GelTopical100 mg/g
SoapTopical
SolutionTopical
LiquidTopical100 mg/.95mL
Solution / dropsOphthalmic100 mg
Solution / dropsOphthalmic300 mg
GelTopical100 mg/mL
LiquidTopical100 mg/mL
ShampooTopical100 mg/mL
SolutionTopical100 mg/g
SwabTopical100 mg/mL
SwabTopical
ClothTopical
RinseTopical
EmulsionTopical
GelTopical
SuspensionTopical
LotionTopical100 mg/mL
OintmentOphthalmic100 mg/g
SolutionOphthalmic100 mg/mL
Solution / dropsOphthalmic100 mg/mL
Solution / dropsOphthalmic300 mg/mL
SuspensionTopical100 mg/mL
SolutionOphthalmic
LotionTopical
LiquidOphthalmic10 %
CreamVaginal
Kit
LiquidOphthalmic
Prices
Unit descriptionCostUnit
Klaron 10% Lotion 118ml Bottle155.38USD bottle
Sulfacetamide-Sulfur Wash 10-4% Emulsion 473ml Bottle138.03USD bottle
Sulfacetamide Sodium-Sulfur 10-5% Lotion 25 gm Bottle70.99USD bottle
Sulfacetamide Sodium-Sulfur 10-5% Suspension 30 gm Tube70.57USD tube
Sulfacetamide Sodium-Sulfur 10-5% Lotion 30 gm Tube63.38USD tube
Sulfacetamide Sod-Sulfur Wash 10-5% Emulsion 170.1 gm Tube55.94USD tube
Bleph-10 10% Solution 5ml Bottle22.7USD bottle
Sulfacetamide Sodium 10% Solution 15ml Bottle12.99USD bottle
Bleph-10 10% eye drops3.89USD ml
Sulfacetamide powder1.55USD g
Klaron 10% lotion1.29USD ml
Sulfacetamide sod cryst powder0.98USD g
Sodium sulfacetamide 10% lot0.94USD ml
Sulfacetamide sod 10% top susp0.8USD ml
Ovace wash 10% liquid0.44USD ml
Re 10 wash0.42USD ml
Sulfacetamide 10% eye drops0.34USD ml
Sulfacetamide 10% ophth sol0.34USD ml
Sulfamide 10% eye drops0.22USD ml
Sodium sulfacetamide powder0.1USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)183 °CPhysProp
water solubility1.25E+004 mg/L (at 37 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP-0.96HANSCH,C ET AL. (1995)
logS-1.23ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility4.21 mg/mLALOGPS
logP0.15ALOGPS
logP-0.26ChemAxon
logS-1.7ALOGPS
pKa (Strongest Acidic)4.3ChemAxon
pKa (Strongest Basic)2.14ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area89.26 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity52.48 m3·mol-1ChemAxon
Polarizability20.49 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9912
Blood Brain Barrier+0.9881
Caco-2 permeable-0.5396
P-glycoprotein substrateNon-substrate0.8806
P-glycoprotein inhibitor INon-inhibitor0.9743
P-glycoprotein inhibitor IINon-inhibitor0.9449
Renal organic cation transporterNon-inhibitor0.9484
CYP450 2C9 substrateNon-substrate0.6975
CYP450 2D6 substrateNon-substrate0.9058
CYP450 3A4 substrateNon-substrate0.7775
CYP450 1A2 substrateNon-inhibitor0.9609
CYP450 2C9 inhibitorNon-inhibitor0.9595
CYP450 2D6 inhibitorNon-inhibitor0.9312
CYP450 2C19 inhibitorNon-inhibitor0.9546
CYP450 3A4 inhibitorNon-inhibitor0.9552
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8371
Ames testNon AMES toxic0.9279
CarcinogenicityNon-carcinogens0.8623
BiodegradationNot ready biodegradable0.9686
Rat acute toxicity1.7849 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9919
hERG inhibition (predictor II)Non-inhibitor0.9775
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)
Download (9.68 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted LC-MS/MS Spectrum - 10V, PositivePredicted LC-MS/MSNot Available
Predicted LC-MS/MS Spectrum - 20V, PositivePredicted LC-MS/MSNot Available
Predicted LC-MS/MS Spectrum - 40V, PositivePredicted LC-MS/MSNot Available
Predicted LC-MS/MS Spectrum - 10V, NegativePredicted LC-MS/MSNot Available
Predicted LC-MS/MS Spectrum - 20V, NegativePredicted LC-MS/MSNot Available
Predicted LC-MS/MS Spectrum - 40V, NegativePredicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzenesulfonamides
Direct Parent
Aminobenzenesulfonamides
Alternative Parents
Benzenesulfonyl compounds / Aniline and substituted anilines / Organosulfonic acids and derivatives / Aminosulfonyl compounds / Acetamides / Amino acids and derivatives / Primary amines / Organopnictogen compounds / Organic oxides / Hydrocarbon derivatives
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Substituents
Aminobenzenesulfonamide / Benzenesulfonyl group / Aniline or substituted anilines / Organic sulfonic acid or derivatives / Organosulfonic acid or derivatives / Sulfonyl / Acetamide / Aminosulfonyl compound / Amino acid or derivatives / Carboxylic acid derivative
show 12 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
substituted aniline, sulfonamide (CHEBI:63845 )

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Yes
Actions
Inhibitor
General Function
Metal ion binding
Specific Function
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Gene Name
folP
Uniprot ID
P0AC13
Uniprot Name
Dihydropteroate synthase
Molecular Weight
30614.855 Da
References
  1. Hevener KE, Zhao W, Ball DM, Babaoglu K, Qi J, White SW, Lee RE: Validation of molecular docking programs for virtual screening against dihydropteroate synthase. J Chem Inf Model. 2009 Feb;49(2):444-60. doi: 10.1021/ci800293n. [PubMed:19434845 ]
  2. BROWN GM: The biosynthesis of folic acid. II. Inhibition by sulfonamides. J Biol Chem. 1962 Feb;237:536-40. [PubMed:13873645 ]
  3. Patel OG, Mberu EK, Nzila AM, Macreadie IG: Sulfa drugs strike more than once. Trends Parasitol. 2004 Jan;20(1):1-3. [PubMed:14700578 ]
Kind
Protein
Organism
Escherichia coli
Pharmacological action
Yes
Actions
Inhibitor
General Function
Metal ion binding
Specific Function
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivativ...
Gene Name
sulI
Uniprot ID
P0C002
Uniprot Name
Dihydropteroate synthase type-1
Molecular Weight
30125.83 Da
References
  1. Patel OG, Mberu EK, Nzila AM, Macreadie IG: Sulfa drugs strike more than once. Trends Parasitol. 2004 Jan;20(1):1-3. [PubMed:14700578 ]
Kind
Protein
Organism
Baker's yeast
Pharmacological action
Yes
Actions
Inhibitor
General Function
Metal ion binding
Specific Function
Catalyzes three sequential steps of tetrahydrofolate biosynthesis.
Gene Name
FOL1
Uniprot ID
P53848
Uniprot Name
Folic acid synthesis protein FOL1
Molecular Weight
93119.085 Da
References
  1. Patel OG, Mberu EK, Nzila AM, Macreadie IG: Sulfa drugs strike more than once. Trends Parasitol. 2004 Jan;20(1):1-3. [PubMed:14700578 ]
Drug created on June 13, 2005 07:24 / Updated on September 01, 2017 10:30