Onychomycosis

Also known as: Onychomycoses / Tinea unguium / Dermatophytic onychia / Nail tinea / Ringworm of nail / Fungal infection of nail / Nail fungal infection NOS / Dermatophytosis of nail

DrugDrug NameDrug Description
DB09040EfinaconazoleEfinaconazole is a 14 alpha-demethylase inhibitor indicated in the treatment of fungal infection of the nail, known as onychomycosis. It was approved for use in Canada and the USA in 2014 and is marketed by Valeant Pharmaceuticals North America LLC under the name Jublia.
DB01167ItraconazoleOne of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
DB09041TavaboroleTavaborale is a novel, boron-based topical antifungal medication for the treatment of onychomycosis, a fungal infection of the nail and nail bed due to *Trichophyton rubrum* or *Trichophyton mentagrophytes* infection. Tavaborole functions by inhibiting Leucyl-tRNA synthetase, or LeuRS, an essential fungal enzyme required for protein synthesis and for the catalysis of ATP-dependent ligation of L-leucine to tRNA(Leu).
DB00857TerbinafineTerbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (squalene 2,3-epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.
DrugDrug NamePhaseStatusCount
DB12073Albaconazole1Completed1
DB05058Tavaborole1Completed1
DB09041Tavaborole1Completed1
DB00857Terbinafine1Unknown Status1
DB08933Luliconazole1 / 2Completed1
DB12073Albaconazole2Completed1
DB09056Amorolfine2Unknown Status1
DB05748Cetylpyridinium2Completed1
DB01188Ciclopirox2Recruiting1
DB01127Econazole2Unknown Status1
DB01167Itraconazole2Completed1
DB13055Oteseconazole2Completed1
DB01263Posaconazole2Completed1
DB05058Tavaborole2Completed5
DB09041Tavaborole2Completed3
DB00857Terbinafine2Completed4
DB09056Amorolfine3Completed2
DB04794Bifonazole3Completed1
DB01188Ciclopirox3Not Yet Recruiting1
DB09040Efinaconazole3Active Not Recruiting1
DB09040Efinaconazole3Completed2
DB01167Itraconazole3Completed1
DB00857Terbinafine3Completed3
DB09056Amorolfine4Completed1
DB09056Amorolfine4Unknown Status1
DB01188Ciclopirox4Completed1
DB01188Ciclopirox4Unknown Status1
DB01093Dimethyl sulfoxide4Recruiting1
DB09040Efinaconazole4Active Not Recruiting1
DB09040Efinaconazole4Completed1
DB01110Miconazole4Unknown Status1
DB09041Tavaborole4Completed1
DB00857Terbinafine4Completed1
DB00857Terbinafine4Unknown Status1
DB09056AmorolfineNot AvailableCompleted1
DB01110MiconazoleNot AvailableUnknown Status1
DB00857TerbinafineNot AvailableCompleted2
DB00857TerbinafineNot AvailableNot Yet Recruiting1
DB00857TerbinafineNot AvailableUnknown Status1