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Identification
NameVoriconazole
Accession NumberDB00582  (APRD00543)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionVoriconazole (Vfend®, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections.
Structure
Thumb
Synonyms
(AlphaR,betas)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
(R-(R*,s*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
VCZ
Vfend
Voriconazol
Voriconazolum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ach-voriconazoleTablet50 mgOralAccord Healthcare IncNot applicableNot applicableCanada
Auro-voriconazoleTablet50 mgOralAuro Pharma IncNot applicableNot applicableCanada
Auro-voriconazoleTablet200 mgOralAuro Pharma IncNot applicableNot applicableCanada
Mylan-voriconazoleTablet50 mgOralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Mylan-voriconazoleTablet200 mgOralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Sandoz VoriconazoleTablet50 mgOralSandoz Canada Incorporated2014-04-02Not applicableCanada
Sandoz VoriconazoleTablet200 mgOralSandoz Canada Incorporated2014-04-02Not applicableCanada
Teva-voriconazoleTablet50 mgOralTeva Canada Limited2014-03-31Not applicableCanada
Teva-voriconazoleTablet200 mgOralTeva Canada Limited2014-03-31Not applicableCanada
VfendTablet200 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet200 mgOralPfizer Canada Inc2004-11-12Not applicableCanada
VfendTablet50 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet200 mgOralPfizer Limited2002-03-19Not applicableEu
VfendPowder, for suspension40 mg/mLOralRoerig2003-03-28Not applicableUs
VfendTablet200 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet50 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet50 mgOralPfizer Limited2002-03-19Not applicableEu
VfendInjection, powder, for solution200 mgIntravenousPfizer Limited2002-03-19Not applicableEu
VfendTablet, film coated200 mg/1OralCardinal Health2002-05-24Not applicableUs
VfendTablet200 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet50 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet200 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet, film coated50 mg/1OralRoerig2003-03-28Not applicableUs
VfendTablet200 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet50 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet50 mgOralPfizer Limited2002-03-19Not applicableEu
VfendPowder, for suspension40 mg/mlOralPfizer Limited2002-03-19Not applicableEu
VfendTablet, film coated50 mg/1OralCardinal Health2002-05-24Not applicableUs
VfendTablet200 mgOralPfizer Limited2002-03-19Not applicableEu
VfendPowder, for suspension3 gOralPfizer Canada Inc2008-07-17Not applicableCanada
VfendTablet50 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet200 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet, film coated200 mg/1OralRoerig2003-03-28Not applicableUs
VfendTablet50 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet200 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet50 mgOralPfizer Limited2002-03-19Not applicableEu
VfendInjection, powder, for solution200 mgIntravenousPfizer Limited2002-03-19Not applicableEu
VfendTablet50 mgOralPfizer Canada Inc2004-11-12Not applicableCanada
VfendTablet50 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet200 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet200 mgOralPfizer Limited2002-03-19Not applicableEu
VfendInjection, powder, lyophilized, for solution10 mg/mLIntravenousRoerig2012-10-24Not applicableUs
VfendInjection, powder, lyophilized, for solution10 mg/mLIntravenousRoerig2002-05-24Not applicableUs
VfendTablet50 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet50 mgOralPfizer Limited2002-03-19Not applicableEu
VfendTablet200 mgOralPfizer Limited2002-03-19Not applicableEu
Vfend for InjectionPowder, for solution200 mgIntravenousPfizer Canada Inc2004-11-12Not applicableCanada
VoriconazoleTablet, film coated50 mg/1OralGreenstone LLC2002-05-01Not applicableUs
VoriconazoleTablet, film coated200 mg/1OralGreenstone LLC2002-05-01Not applicableUs
VoriconazolePowder, for suspension40 mg/mLOralGreenstone LLC2013-12-16Not applicableUs
Voriconazole for InjectionPowder, for solution200 mgIntravenousHospira Healthcare CorporationNot applicableNot applicableCanada
Voriconazole for InjectionPowder, for solution200 mgIntravenousSandoz Canada Incorporated2014-04-30Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-voriconazoleTablet200 mgOralApotex Inc2014-04-14Not applicableCanada
Apo-voriconazoleTablet50 mgOralApotex Inc2014-04-14Not applicableCanada
VoriconazolePowder, for suspension40 mg/mLOralAmneal Pharmaceuticals of New York, LLC2013-11-29Not applicableUs
VoriconazoleTablet, film coated200 mg/1OralMylan Institutional Inc.2011-08-08Not applicableUs
VoriconazoleTablet50 mg/1OralNorthstar Rx LLC2016-07-04Not applicableUs
VoriconazoleTablet, film coated50 mg/1OralLupin Pharmaceuticals,inc.2016-05-24Not applicableUs
VoriconazoleTablet, film coated50 mg/1OralTeva Pharmaceuticals USA Inc2012-06-01Not applicableUs
VoriconazoleTablet, film coated50 mg/1OralAmerican Health Packaging2014-01-07Not applicableUs
VoriconazoleSuspension40 mg/mLOralNovel Laboratories, Inc.2016-06-01Not applicableUs
VoriconazoleTablet200 mg/1OralZydus Pharmaceuticals (USA) Inc.2016-05-25Not applicableUs
VoriconazolePowder, for suspension40 mg/mLOralMylan Pharmaceuticals Inc.2013-09-25Not applicableUs
VoriconazoleInjection, powder, lyophilized, for solution10 mg/mLIntravenousSandoz Inc2012-05-30Not applicableUs
VoriconazoleTablet200 mg/1OralAppco Pharma Llc2016-05-26Not applicableUs
VoriconazoleTablet50 mg/1OralCadila Healthcare Limited2016-05-25Not applicableUs
VoriconazoleTablet, film coated200 mg/1OralCardinal Health2012-09-21Not applicableUs
VoriconazoleTablet200 mg/1OralNorthstar Rx LLC2016-07-04Not applicableUs
VoriconazoleTablet, film coated200 mg/1OralLupin Pharmaceuticals,inc.2016-05-24Not applicableUs
VoriconazoleTablet, film coated200 mg/1OralTeva Pharmaceuticals USA Inc2012-06-01Not applicableUs
VoriconazoleTablet, film coated50 mg/1OralAurobindo Pharma Limited2016-01-22Not applicableUs
VoriconazoleTablet, film coated50 mg/1OralGlenmark Pharmaceuticals Inc., Usa2015-09-04Not applicableUs
VoriconazoleTablet, film coated50 mg/1OralNovel Laboratories, Inc.2016-05-24Not applicableUs
VoriconazoleTablet, coated50 mg/1OralSolco healthcare U.S., LLC2016-10-28Not applicableUs
VoriconazoleTablet, film coated200 mg/1OralMajor Pharmaceuticals2015-03-25Not applicableUs
VoriconazoleTablet, film coated50 mg/1OralSandoz Inc2011-12-12Not applicableUs
VoriconazoleTablet, film coated50 mg/1OralVersa Pharm Incorporated2016-09-07Not applicableUs
VoriconazoleTablet200 mg/1OralCadila Healthcare Limited2016-05-25Not applicableUs
VoriconazoleTablet, film coated200 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2011-12-12Not applicableUs
VoriconazoleTablet50 mg/1OralAjanta Pharma Limited2016-05-31Not applicableUs
VoriconazoleInjection, powder, for solution10 mg/mLIntravenousAlvogen Inc.2016-08-08Not applicableUs
VoriconazoleTablet, film coated50 mg/1OralMylan Pharmaceuticals Inc.2011-02-15Not applicableUs
VoriconazoleTablet, film coated200 mg/1OralAurobindo Pharma Limited2016-01-22Not applicableUs
VoriconazoleTablet, film coated200 mg/1OralGlenmark Pharmaceuticals Inc., Usa2015-09-04Not applicableUs
VoriconazoleTablet, film coated200 mg/1OralNovel Laboratories, Inc.2016-05-24Not applicableUs
VoriconazoleTablet, coated200 mg/1OralSolco healthcare U.S., LLC2016-10-28Not applicableUs
VoriconazoleTablet, film coated50 mg/1OralMylan Institutional Inc.2011-08-08Not applicableUs
VoriconazoleTablet, film coated200 mg/1OralSandoz Inc2011-12-12Not applicableUs
VoriconazoleTablet, film coated200 mg/1OralVersa Pharm Incorporated2016-09-07Not applicableUs
VoriconazoleTablet200 mg/1OralAjanta Pharma Limited2016-05-31Not applicableUs
VoriconazoleTablet50 mg/1OralZydus Pharmaceuticals (USA) Inc.2016-05-25Not applicableUs
VoriconazoleTablet, film coated200 mg/1OralAmerican Health Packaging2012-05-01Not applicableUs
VoriconazoleTablet, film coated200 mg/1OralAv Kare, Inc.2016-02-25Not applicableUs
VoriconazoleTablet50 mg/1OralAppco Pharma Llc2016-05-26Not applicableUs
VoriconazoleTablet, film coated200 mg/1OralMylan Pharmaceuticals Inc.2011-02-15Not applicableUs
VoriconazolePowder, for suspension40 mg/mLOralLupin Pharmaceuticals,inc.2016-06-01Not applicableUs
Voriconazole AccordTablet, film coated50 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated50 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated200 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated200 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated50 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated50 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated50 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated200 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated50 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated50 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated200 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated200 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated50 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated50 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated50 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated200 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated50 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated50 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated200 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated200 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated200 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated200 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated200 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated50 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated50 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated50 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated200 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated200 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated200 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Voriconazole AccordTablet, film coated200 mgOralAccord Healthcare Ltd2013-05-16Not applicableEu
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIJFU09I87TR
CAS number137234-62-9
WeightAverage: 349.3105
Monoisotopic: 349.11504471
Chemical FormulaC16H14F3N5O
InChI KeyBCEHBSKCWLPMDN-MGPLVRAMSA-N
InChI
InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
IUPAC Name
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
SMILES
C[C@@H](C1=NC=NC=C1F)[C@](O)(CN1C=NC=N1)C1=C(F)C=C(F)C=C1
Pharmacology
IndicationFor the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.
Structured Indications
PharmacodynamicsVoriconazole is a triazole antifungal agent indicated for use in the treatment of fungal infections including invasive aspergillosis, esophageal candidiasis, and serious fungal infections caused by Scedosporium apiospermum (asexual form of Pseudallescheria boydii) and Fusarium spp. including Fusarium solani. Fungal plasma membranes are similar to mammalian plasma membranes, differing in having the nonpolar sterol ergosterol, rather than cholesterol, as the principal sterol. Membrane sterols such as ergosterol provide structure, modulation of membrane fluidity, and possibly control of some physiologic events. Voriconazole effects the formation of the fungal plasma membrane by indirectly inhibiting the biosynthesis of ergosterol. This results in plasma membrane permeability changes and inhibition of growth.
Mechanism of actionVoriconazole binds and inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-alpha sterol demethylase. The inhibition of 14-alpha sterol demethylase results in a depletion of ergosterol in fungal cell membrane.
TargetKindPharmacological actionActionsOrganismUniProt ID
Lanosterol 14-alpha demethylaseProteinyes
antagonist
inhibitor
YeastP10613 details
Related Articles
AbsorptionThe oral bioavailability is estimated to be 96% (CV 13%).
Volume of distribution
  • 4.6 L/kg
Protein binding58%
Metabolism

Hepatic. The major metabolite of voriconazole is the N-oxide, which accounts for 72% of the circulating radiolabelled metabolites in plasma. Since this metabolite has minimal antifungal activity, it does not contribute to the overall efficacy of voriconazole.

SubstrateEnzymesProduct
Voriconazole
UK-121,265 (Voriconazole N-oxide)Details
Voriconazole
4-HydroxyvoriconazoleDetails
4-Hydroxyvoriconazole
Not Available
4-Hydroxyvoriconazole 4-O-glucuronideDetails
UK-121,265 (Voriconazole N-oxide)
Not Available
UK-51,060Details
UK-51,060
Not Available
UK-215,364Details
UK-215,364
Not Available
Voriconazole O-glucuronide derivative (1)Details
Route of eliminationVoriconazole is eliminated via hepatic metabolism with less than 2% of the dose excreted unchanged in the urine.
Half lifeNot Available
ClearanceNot Available
ToxicityThe minimum lethal oral dose in mice and rats was 300 mg/kg (equivalent to 4 and 7 times the recommended maintenance dose (RMD), based on body surface area). At this dose, clinical signs observed in both mice and rats included salivation, mydriasis, titubation (loss of balance while moving), depressed behavior, prostration, partially closed eyes, and dyspnea. Other signs in mice were convulsions, corneal opacification and swollen abdomen.
Affected organisms
  • Yeast and other fungi
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Voriconazole.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Voriconazole.Experimental, Illicit
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Voriconazole.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Voriconazole.Experimental, Illicit
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Voriconazole.Approved
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Voriconazole.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Voriconazole.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Voriconazole.Approved
AcetohexamideThe serum concentration of Acetohexamide can be increased when it is combined with Voriconazole.Withdrawn
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be decreased when combined with Voriconazole.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Voriconazole.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Voriconazole.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Voriconazole.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Voriconazole.Experimental
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Voriconazole.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Voriconazole.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Voriconazole.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Voriconazole.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Voriconazole.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Voriconazole.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Voriconazole.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Voriconazole.Approved, Illicit, Investigational
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Voriconazole.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Voriconazole.Approved
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Voriconazole.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Voriconazole.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Voriconazole.Approved
AmiodaroneThe metabolism of Voriconazole can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Voriconazole.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Voriconazole.Approved
AmobarbitalThe serum concentration of Voriconazole can be decreased when it is combined with Amobarbital.Approved, Illicit
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Voriconazole.Approved, Vet Approved
Amphotericin BThe therapeutic efficacy of Amphotericin B can be decreased when used in combination with Voriconazole.Approved, Investigational
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Voriconazole.Approved
AmrinoneThe risk or severity of adverse effects can be increased when Voriconazole is combined with Amrinone.Approved
AnagrelideVoriconazole may increase the QTc-prolonging activities of Anagrelide.Approved
AnecortaveThe serum concentration of Anecortave can be increased when it is combined with Voriconazole.Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Voriconazole.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Voriconazole.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Voriconazole.Approved, Investigational
AprepitantThe serum concentration of Voriconazole can be increased when it is combined with Aprepitant.Approved, Investigational
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Voriconazole.Experimental
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Voriconazole.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Voriconazole.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Voriconazole.Approved, Investigational
ArmodafinilThe metabolism of Voriconazole can be decreased when combined with Armodafinil.Approved, Investigational
Arsenic trioxideVoriconazole may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Voriconazole.Approved
AsenapineThe metabolism of Asenapine can be decreased when combined with Voriconazole.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Voriconazole.Approved, Withdrawn
AtazanavirThe serum concentration of Voriconazole can be decreased when it is combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Voriconazole can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Voriconazole.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Voriconazole.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Voriconazole.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Voriconazole.Approved
AzelnidipineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Azelnidipine.Approved
AzimilideThe risk or severity of adverse effects can be increased when Voriconazole is combined with Azimilide.Investigational
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Voriconazole.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Voriconazole.Investigational
BarbexacloneThe serum concentration of Voriconazole can be decreased when it is combined with Barbexaclone.Experimental
BarbitalThe serum concentration of Voriconazole can be decreased when it is combined with Barbital.Illicit
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Voriconazole.Approved
BeclomethasoneThe serum concentration of Beclomethasone can be increased when it is combined with Voriconazole.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Voriconazole.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Voriconazole.Approved
BenidipineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Benidipine.Approved
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Voriconazole.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Voriconazole.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Voriconazole.Approved
BepridilThe risk or severity of adverse effects can be increased when Voriconazole is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Voriconazole.Approved, Vet Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Voriconazole.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Voriconazole.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Voriconazole.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Voriconazole.Approved
BoceprevirThe serum concentration of Voriconazole can be increased when it is combined with Boceprevir.Approved
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Voriconazole.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Voriconazole.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Voriconazole.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Voriconazole.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Voriconazole.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Voriconazole.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Voriconazole.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Voriconazole.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Voriconazole.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Voriconazole.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Voriconazole.Approved
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Voriconazole.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Voriconazole.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Voriconazole.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Voriconazole.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Voriconazole.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Voriconazole.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Voriconazole.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Voriconazole.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Voriconazole.Approved
CaiThe risk or severity of adverse effects can be increased when Voriconazole is combined with Cai.Investigational
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Voriconazole.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Voriconazole.Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Voriconazole.Approved
CapecitabineThe metabolism of Voriconazole can be decreased when combined with Capecitabine.Approved, Investigational
CarbamazepineThe serum concentration of Voriconazole can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Voriconazole.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Voriconazole.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Voriconazole.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Voriconazole.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Voriconazole.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Voriconazole.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Voriconazole.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Voriconazole.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Voriconazole.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Voriconazole.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Voriconazole.Approved
ChloramphenicolThe serum concentration of Voriconazole can be increased when it is combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Voriconazole.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Voriconazole.Approved, Vet Approved
ChlorotrianiseneThe metabolism of Chlorotrianisene can be decreased when combined with Voriconazole.Withdrawn
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Voriconazole.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Voriconazole.Approved, Vet Approved
ChlorpropamideThe serum concentration of Chlorpropamide can be increased when it is combined with Voriconazole.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Voriconazole.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Voriconazole.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Voriconazole.Approved, Investigational
CilnidipineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Cilnidipine.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Voriconazole.Approved
CimetidineThe metabolism of Voriconazole can be decreased when combined with Cimetidine.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Voriconazole.Approved
CinnarizineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Cinnarizine.Approved
CiprofloxacinVoriconazole may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Voriconazole.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Voriconazole.Approved
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Voriconazole.Approved
ClemastineThe metabolism of Voriconazole can be decreased when combined with Clemastine.Approved
ClevidipineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Clevidipine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Voriconazole.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Voriconazole.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be increased when it is combined with Voriconazole.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Voriconazole.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Voriconazole.Approved
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Voriconazole.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Voriconazole.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Voriconazole.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Voriconazole.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Voriconazole.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Voriconazole.Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Voriconazole resulting in a loss in efficacy.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Voriconazole.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Voriconazole.Approved, Illicit
ClotrimazoleThe metabolism of Voriconazole can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Voriconazole.Approved
CobicistatThe serum concentration of Cobicistat can be increased when it is combined with Voriconazole.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Voriconazole.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Voriconazole.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Voriconazole.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Voriconazole.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Voriconazole.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Voriconazole.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Voriconazole.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Voriconazole.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Voriconazole.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Voriconazole.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Voriconazole.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Voriconazole.Approved, Investigational
DabrafenibThe serum concentration of Voriconazole can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Voriconazole.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Voriconazole.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Voriconazole.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Voriconazole.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Voriconazole.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Voriconazole.Approved, Investigational
DarodipineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Darodipine.Experimental
DarunavirThe serum concentration of Voriconazole can be decreased when it is combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Voriconazole.Approved
DasatinibVoriconazole may increase the QTc-prolonging activities of Dasatinib.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Voriconazole.Approved
DeferasiroxThe serum concentration of Voriconazole can be decreased when it is combined with Deferasirox.Approved, Investigational
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Voriconazole.Investigational
DelavirdineThe serum concentration of Voriconazole can be decreased when it is combined with Delavirdine.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Voriconazole.Approved
DesogestrelThe serum concentration of Desogestrel can be increased when it is combined with Voriconazole.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Voriconazole.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Voriconazole.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Voriconazole.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Voriconazole.Approved
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Voriconazole.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Voriconazole.Vet Approved
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Voriconazole.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Voriconazole.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Voriconazole.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Voriconazole.Approved, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Voriconazole.Approved, Vet Approved
DicoumarolThe serum concentration of Dicoumarol can be increased when it is combined with Voriconazole.Approved
DidanosineDidanosine can cause a decrease in the absorption of Voriconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DienestrolThe metabolism of Dienestrol can be decreased when combined with Voriconazole.Approved
DienogestThe serum concentration of Dienogest can be increased when it is combined with Voriconazole.Approved
DiethylstilbestrolThe metabolism of Diethylstilbestrol can be decreased when combined with Voriconazole.Approved
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Voriconazole.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Voriconazole.Approved
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Voriconazole.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Voriconazole.Approved
DigoxinThe metabolism of Digoxin can be decreased when combined with Voriconazole.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Voriconazole.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Voriconazole.Approved
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Voriconazole.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Voriconazole.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Voriconazole.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Voriconazole.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Voriconazole.Approved, Investigational
DofetilideThe metabolism of Dofetilide can be decreased when combined with Voriconazole.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Voriconazole.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Voriconazole.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Voriconazole.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Voriconazole.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Voriconazole.Approved
DotarizineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Dotarizine.Investigational
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Voriconazole.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Voriconazole.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Voriconazole.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Voriconazole.Approved, Investigational
DoxycyclineThe metabolism of Voriconazole can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Voriconazole.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Voriconazole.Approved
DroperidolVoriconazole may increase the QTc-prolonging activities of Droperidol.Approved, Vet Approved
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Voriconazole.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Voriconazole.Approved, Investigational
EfavirenzThe serum concentration of Voriconazole can be decreased when it is combined with Efavirenz.Approved, Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Efonidipine.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Voriconazole.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Voriconazole.Approved
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Voriconazole.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Voriconazole.Approved, Vet Approved
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Voriconazole.Approved, Investigational
EnzalutamideThe serum concentration of Voriconazole can be decreased when it is combined with Enzalutamide.Approved
EperisoneThe risk or severity of adverse effects can be increased when Voriconazole is combined with Eperisone.Approved, Investigational
EpinastineThe metabolism of Epinastine can be decreased when combined with Voriconazole.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Voriconazole.Approved
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Voriconazole.Approved
EquileninThe serum concentration of Equilenin can be increased when it is combined with Voriconazole.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Voriconazole.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Voriconazole.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Voriconazole.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Voriconazole.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Voriconazole.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Voriconazole.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Voriconazole.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Voriconazole.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Voriconazole can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Voriconazole.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Voriconazole.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Voriconazole.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Voriconazole.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Voriconazole.Approved
Estrogens, esterifiedThe metabolism of Estrogens, esterified can be decreased when combined with Voriconazole.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Voriconazole.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Voriconazole.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Voriconazole.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Voriconazole.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Voriconazole.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Voriconazole.Approved
Ethyl biscoumacetateThe serum concentration of Ethyl biscoumacetate can be increased when it is combined with Voriconazole.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Voriconazole.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be increased when it is combined with Voriconazole.Approved
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Voriconazole.Approved
EtodolacThe metabolism of Etodolac can be decreased when combined with Voriconazole.Approved, Investigational, Vet Approved
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Voriconazole.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Voriconazole.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Voriconazole.Approved, Investigational
EtravirineThe serum concentration of Voriconazole can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Voriconazole.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Voriconazole.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Voriconazole.Approved
FamotidineThe metabolism of Famotidine can be decreased when combined with Voriconazole.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Voriconazole.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Voriconazole.Approved, Investigational
FendilineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Fendiline.Withdrawn
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Voriconazole.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Voriconazole.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Voriconazole.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Voriconazole.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Voriconazole.Approved, Investigational
FlecainideVoriconazole may increase the QTc-prolonging activities of Flecainide.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Voriconazole.Approved
FloxuridineThe metabolism of Voriconazole can be decreased when combined with Floxuridine.Approved
fluasteroneThe serum concentration of fluasterone can be increased when it is combined with Voriconazole.Investigational
FluconazoleThe serum concentration of Voriconazole can be increased when it is combined with Fluconazole.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Voriconazole.Approved
FluindioneThe serum concentration of Fluindione can be increased when it is combined with Voriconazole.Investigational
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Voriconazole.Approved, Vet Approved
FlunarizineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Flunarizine.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Voriconazole.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Voriconazole.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Voriconazole.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Voriconazole.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Voriconazole.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Voriconazole.Approved
FluorouracilThe metabolism of Voriconazole can be decreased when combined with Fluorouracil.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Voriconazole.Approved, Vet Approved
FlupentixolVoriconazole may increase the QTc-prolonging activities of Flupentixol.Approved, Withdrawn
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Voriconazole.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Voriconazole.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Voriconazole.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Voriconazole.Approved, Illicit
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Voriconazole.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Voriconazole.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Voriconazole.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Voriconazole.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Voriconazole.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Voriconazole.Approved
FluvoxamineThe metabolism of Voriconazole can be decreased when combined with Fluvoxamine.Approved, Investigational
FormestaneThe serum concentration of Formestane can be increased when it is combined with Voriconazole.Approved, Investigational, Withdrawn
FormoterolThe metabolism of Formoterol can be decreased when combined with Voriconazole.Approved, Investigational
FosamprenavirThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Voriconazole.Approved
FosaprepitantThe serum concentration of Voriconazole can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Voriconazole can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Voriconazole.Approved, Investigational
Fusidic AcidThe serum concentration of Voriconazole can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Voriconazole is combined with Gabapentin.Approved, Investigational
Gadobenic acidVoriconazole may increase the QTc-prolonging activities of Gadobenic acid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Voriconazole.Approved
GallopamilThe risk or severity of adverse effects can be increased when Voriconazole is combined with Gallopamil.Investigational
GavestinelThe metabolism of Gavestinel can be decreased when combined with Voriconazole.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Voriconazole.Approved, Investigational
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Voriconazole.Approved
GemifloxacinVoriconazole may increase the QTc-prolonging activities of Gemifloxacin.Approved, Investigational
GestodeneThe serum concentration of Gestodene can be increased when it is combined with Voriconazole.Approved
GlibornurideThe serum concentration of Glibornuride can be increased when it is combined with Voriconazole.Withdrawn
GliclazideThe serum concentration of Gliclazide can be increased when it is combined with Voriconazole.Approved
GlimepirideThe serum concentration of Glimepiride can be increased when it is combined with Voriconazole.Approved
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Voriconazole.Approved
GliquidoneThe serum concentration of Gliquidone can be increased when it is combined with Voriconazole.Approved
GlisoxepideThe serum concentration of Glisoxepide can be increased when it is combined with Voriconazole.Approved
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Voriconazole.Approved
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Voriconazole.Approved
GoserelinVoriconazole may increase the QTc-prolonging activities of Goserelin.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Voriconazole.Approved, Investigational
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Voriconazole.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Voriconazole.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Voriconazole.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Voriconazole.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Voriconazole.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be increased when it is combined with Voriconazole.Investigational
HexestrolThe metabolism of Hexestrol can be decreased when combined with Voriconazole.Withdrawn
HexobarbitalThe serum concentration of Voriconazole can be decreased when it is combined with Hexobarbital.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Voriconazole.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Voriconazole.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Voriconazole.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Voriconazole.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Voriconazole.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Voriconazole.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Voriconazole.Approved
IbutilideVoriconazole may increase the QTc-prolonging activities of Ibutilide.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Voriconazole.Approved
IdelalisibThe serum concentration of Voriconazole can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Voriconazole resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Voriconazole.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Voriconazole.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Voriconazole.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Voriconazole.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Voriconazole.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Voriconazole.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Voriconazole.Approved
IndinavirThe metabolism of Voriconazole can be decreased when combined with Indinavir.Approved
indisulamThe metabolism of indisulam can be decreased when combined with Voriconazole.Investigational
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Voriconazole.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Voriconazole.Approved
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Voriconazole.Approved, Investigational
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Voriconazole.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Voriconazole.Approved, Investigational
IsoniazidThe metabolism of Voriconazole can be decreased when combined with Isoniazid.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Voriconazole.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Voriconazole.Approved
IsradipineThe metabolism of Isradipine can be decreased when combined with Voriconazole.Approved
IstaroximeThe serum concentration of Istaroxime can be increased when it is combined with Voriconazole.Investigational
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Voriconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Voriconazole.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Voriconazole.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Voriconazole.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Voriconazole.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Voriconazole.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Voriconazole.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Voriconazole.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Voriconazole.Approved
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Voriconazole.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Voriconazole.Approved, Vet Approved
LacidipineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Lacidipine.Approved
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Voriconazole.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Lamotrigine.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Voriconazole.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Voriconazole.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Voriconazole.Investigational
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Voriconazole.Approved, Investigational
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Voriconazole.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Voriconazole.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Voriconazole.Approved
LetrozoleThe metabolism of Letrozole can be decreased when combined with Voriconazole.Approved, Investigational
LeuprolideVoriconazole may increase the QTc-prolonging activities of Leuprolide.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Voriconazole.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Voriconazole.Approved
LevofloxacinVoriconazole may increase the QTc-prolonging activities of Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Voriconazole.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Voriconazole.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Voriconazole.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Voriconazole.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Voriconazole.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Voriconazole.Approved, Vet Approved
LisurideThe metabolism of Lisuride can be decreased when combined with Voriconazole.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Voriconazole.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Voriconazole.Approved
LopinavirThe serum concentration of Voriconazole can be decreased when it is combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Voriconazole.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Voriconazole.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Voriconazole.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Voriconazole.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Voriconazole.Approved, Investigational
LuliconazoleThe serum concentration of Voriconazole can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Voriconazole can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Voriconazole.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Voriconazole.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Voriconazole.Approved
LynestrenolThe serum concentration of Lynestrenol can be increased when it is combined with Voriconazole.Investigational
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Voriconazole.Approved
Magnesium SulfateThe risk or severity of adverse effects can be increased when Voriconazole is combined with Magnesium Sulfate.Approved, Vet Approved
ManidipineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Manidipine.Approved
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Voriconazole.Approved, Investigational
ME-609The serum concentration of ME-609 can be increased when it is combined with Voriconazole.Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Voriconazole.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Voriconazole.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Voriconazole.Approved
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Voriconazole.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Voriconazole.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Voriconazole.Approved, Nutraceutical, Vet Approved
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Voriconazole.Vet Approved
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Voriconazole.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Voriconazole.Investigational, Withdrawn
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Voriconazole.Approved, Illicit
MestranolThe metabolism of Mestranol can be decreased when combined with Voriconazole.Approved
MethadoneThe serum concentration of Methadone can be increased when it is combined with Voriconazole.Approved
MethallenestrilThe metabolism of Methallenestril can be decreased when combined with Voriconazole.Experimental
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Voriconazole.Illicit, Withdrawn
MethohexitalThe serum concentration of Voriconazole can be decreased when it is combined with Methohexital.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Voriconazole.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Voriconazole.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Voriconazole.Approved
MethylergometrineThe serum concentration of Methylergometrine can be increased when it is combined with Voriconazole.Approved
MethylphenobarbitalThe serum concentration of Voriconazole can be decreased when it is combined with Methylphenobarbital.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Voriconazole.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Voriconazole.Approved
MetoprololThe metabolism of Metoprolol can be decreased when combined with Voriconazole.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Voriconazole.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Voriconazole.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Voriconazole.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Voriconazole.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Voriconazole.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be decreased when combined with Voriconazole.Approved, Illicit
MifepristoneThe serum concentration of Voriconazole can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe metabolism of Mirabegron can be decreased when combined with Voriconazole.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Voriconazole.Approved
MitotaneThe serum concentration of Voriconazole can be decreased when it is combined with Mitotane.Approved
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Voriconazole.Approved
ModafinilThe metabolism of Modafinil can be decreased when combined with Voriconazole.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Voriconazole.Approved, Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Voriconazole.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Voriconazole.Approved, Investigational
MoxifloxacinVoriconazole may increase the QTc-prolonging activities of Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Voriconazole.Approved, Investigational
NafcillinThe serum concentration of Voriconazole can be decreased when it is combined with Nafcillin.Approved
NaftopidilThe risk or severity of adverse effects can be increased when Voriconazole is combined with Naftopidil.Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Voriconazole.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Voriconazole.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Voriconazole.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Voriconazole.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Voriconazole.Investigational
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Voriconazole.Approved, Withdrawn
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Voriconazole.Approved
NetupitantThe serum concentration of Voriconazole can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Voriconazole can be decreased when it is combined with Nevirapine.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Voriconazole.Approved
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Voriconazole.Approved, Vet Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Voriconazole.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Voriconazole.Approved
NiguldipineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Niguldipine.Experimental
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Voriconazole.Approved, Investigational
NiludipineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Niludipine.Experimental
NilutamideThe metabolism of Nilutamide can be decreased when combined with Voriconazole.Approved
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Voriconazole.Approved
NimesulideThe risk or severity of adverse effects can be increased when Voriconazole is combined with Nimesulide.Approved, Withdrawn
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Voriconazole.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Voriconazole.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Voriconazole.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Voriconazole.Approved
NorelgestrominThe serum concentration of Norelgestromin can be increased when it is combined with Voriconazole.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Voriconazole.Approved
NorgestimateThe serum concentration of Norgestimate can be increased when it is combined with Voriconazole.Approved
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Voriconazole.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Voriconazole.Approved
OfloxacinVoriconazole may increase the QTc-prolonging activities of Ofloxacin.Approved
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Voriconazole.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be increased when it is combined with Voriconazole.Investigational
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Voriconazole.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Voriconazole.Approved
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Voriconazole.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Voriconazole.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Voriconazole.Approved
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Voriconazole.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Voriconazole.Approved
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Voriconazole.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Voriconazole.Approved
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Voriconazole.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Voriconazole.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Voriconazole is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Voriconazole.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Voriconazole.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Voriconazole.Approved
PaliperidoneVoriconazole may increase the QTc-prolonging activities of Paliperidone.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Voriconazole.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Voriconazole.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Voriconazole.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Voriconazole.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Voriconazole.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Voriconazole.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Voriconazole.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Voriconazole.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Voriconazole.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Voriconazole.Approved
PentobarbitalThe serum concentration of Voriconazole can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Voriconazole.Approved
PerflutrenVoriconazole may increase the QTc-prolonging activities of Perflutren.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Voriconazole.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Voriconazole.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Voriconazole.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Voriconazole.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Voriconazole.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Voriconazole.Withdrawn
PhenindioneThe serum concentration of Phenindione can be increased when it is combined with Voriconazole.Approved
PhenobarbitalThe serum concentration of Voriconazole can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Voriconazole.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Voriconazole.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Voriconazole.Approved, Vet Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Voriconazole.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Voriconazole.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Voriconazole.Approved, Investigational
PimozideVoriconazole may increase the arrhythmogenic activities of Pimozide.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Voriconazole.Withdrawn
PinaveriumThe risk or severity of adverse effects can be increased when Voriconazole is combined with Pinaverium.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Voriconazole.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Voriconazole.Approved
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Voriconazole.Approved, Investigational
PitavastatinThe metabolism of Pitavastatin can be decreased when combined with Voriconazole.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Voriconazole.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Voriconazole.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Voriconazole.Approved
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Voriconazole.Approved, Investigational, Vet Approved
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Voriconazole.Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Voriconazole.Approved, Nutraceutical
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Voriconazole resulting in a loss in efficacy.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Voriconazole.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Voriconazole.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Voriconazole.Approved, Vet Approved
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Voriconazole.Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Voriconazole.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Voriconazole.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Voriconazole.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Voriconazole is combined with Pregabalin.Approved, Illicit, Investigational
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Voriconazole.Experimental
PrenylamineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Prenylamine.Withdrawn
PrimaquineThe metabolism of Primaquine can be decreased when combined with Voriconazole.Approved
PrimidoneThe serum concentration of Voriconazole can be decreased when it is combined with Primidone.Approved, Vet Approved
ProcainamideVoriconazole may increase the QTc-prolonging activities of Procainamide.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Voriconazole.Approved, Vet Approved
ProgesteroneThe therapeutic efficacy of Progesterone can be decreased when used in combination with Voriconazole.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Voriconazole.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Voriconazole.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Voriconazole.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Voriconazole.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Voriconazole.Approved, Investigational
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Voriconazole.Approved
PyrimethamineThe metabolism of Voriconazole can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Voriconazole.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Voriconazole.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Voriconazole.Approved
QuinidineThe metabolism of Quinidine can be decreased when combined with Voriconazole.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Voriconazole.Approved
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Voriconazole.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Voriconazole.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Voriconazole.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be decreased when combined with Voriconazole.Approved
RanolazineThe metabolism of Ranolazine can be decreased when combined with Voriconazole.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Voriconazole.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Voriconazole.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Voriconazole.Approved, Investigational
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Voriconazole.Approved
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Voriconazole.Approved
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Voriconazole.Approved
RifapentineThe serum concentration of Rifapentine can be increased when it is combined with Voriconazole.Approved
RilpivirineThe serum concentration of Voriconazole can be decreased when it is combined with Rilpivirine.Approved
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Voriconazole.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Voriconazole.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Voriconazole.Approved
RisedronateThe risk or severity of adverse effects can be increased when Voriconazole is combined with Risedronate.Approved, Investigational
RisperidoneThe metabolism of Risperidone can be decreased when combined with Voriconazole.Approved, Investigational
RitonavirThe serum concentration of Voriconazole can be decreased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Voriconazole.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Voriconazole.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Voriconazole.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Voriconazole.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Voriconazole.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Voriconazole.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Voriconazole.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Voriconazole.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Voriconazole.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Voriconazole.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Voriconazole.Approved
Salicylic acidThe metabolism of Salicylic acid can be decreased when combined with Voriconazole.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Voriconazole.Approved
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Voriconazole.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Voriconazole.Approved
SecobarbitalThe serum concentration of Voriconazole can be decreased when it is combined with Secobarbital.Approved, Vet Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Voriconazole.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Voriconazole.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Voriconazole.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Voriconazole.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Voriconazole.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Voriconazole.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Voriconazole.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Voriconazole.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Voriconazole.Approved
SiltuximabThe serum concentration of Voriconazole can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Voriconazole.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Voriconazole.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Voriconazole.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Voriconazole.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Voriconazole.Approved, Investigational, Withdrawn
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Voriconazole.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Voriconazole.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Voriconazole.Approved, Investigational
SotalolVoriconazole may increase the QTc-prolonging activities of Sotalol.Approved
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Voriconazole.Approved
St. John's WortThe serum concentration of Voriconazole can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Voriconazole can be increased when it is combined with Stiripentol.Approved
SucralfateSucralfate can cause a decrease in the absorption of Voriconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Voriconazole.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Voriconazole.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Voriconazole.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Voriconazole.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Voriconazole.Approved
SulfisoxazoleThe metabolism of Voriconazole can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Voriconazole.Approved, Investigational
SuprofenThe metabolism of Suprofen can be decreased when combined with Voriconazole.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Voriconazole.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Voriconazole.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Voriconazole.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Voriconazole.Approved, Investigational
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Voriconazole.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Voriconazole.Approved, Investigational
TAK-390MRThe serum concentration of TAK-390MR can be increased when it is combined with Voriconazole.Investigational
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Voriconazole.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Voriconazole.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Voriconazole.Approved
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Voriconazole.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Voriconazole.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Voriconazole.Experimental
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Voriconazole.Approved
TelavancinVoriconazole may increase the QTc-prolonging activities of Telavancin.Approved
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Voriconazole.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Voriconazole.Approved
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Voriconazole.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Voriconazole.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Voriconazole.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Voriconazole.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Voriconazole.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Voriconazole.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Voriconazole.Approved, Investigational
TetrabenazineVoriconazole may increase the QTc-prolonging activities of Tetrabenazine.Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Voriconazole.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Voriconazole.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be decreased when combined with Voriconazole.Approved
ThiamylalThe serum concentration of Voriconazole can be decreased when it is combined with Thiamylal.Approved, Vet Approved
ThiopentalThe serum concentration of Voriconazole can be decreased when it is combined with Thiopental.Approved, Vet Approved
ThioridazineVoriconazole may increase the QTc-prolonging activities of Thioridazine.Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Voriconazole.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Voriconazole.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Voriconazole resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Voriconazole.Approved
TimololThe metabolism of Timolol can be decreased when combined with Voriconazole.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Voriconazole.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Voriconazole.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Voriconazole.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Voriconazole.Approved
TocilizumabThe serum concentration of Voriconazole can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Voriconazole.Approved, Investigational
TolazamideThe serum concentration of Tolazamide can be increased when it is combined with Voriconazole.Approved
TolbutamideThe serum concentration of Tolbutamide can be increased when it is combined with Voriconazole.Approved
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Voriconazole is combined with Tolfenamic Acid.Approved
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Voriconazole.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Voriconazole.Approved
TopiramateThe metabolism of Voriconazole can be decreased when combined with Topiramate.Approved
TorasemideThe metabolism of Torasemide can be decreased when combined with Voriconazole.Approved
ToremifeneThe risk or severity of adverse effects can be increased when Voriconazole is combined with Toremifene.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Voriconazole.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Voriconazole.Approved, Investigational
TranilastThe risk or severity of adverse effects can be increased when Voriconazole is combined with Tranilast.Approved, Investigational
TranylcypromineThe metabolism of Voriconazole can be decreased when combined with Tranylcypromine.Approved
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Voriconazole.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Voriconazole.Approved, Investigational
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Voriconazole.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Voriconazole.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Voriconazole.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Voriconazole.Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Voriconazole.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Voriconazole.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Voriconazole.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Voriconazole.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Voriconazole.Approved
UdenafilThe metabolism of Udenafil can be decreased when combined with Voriconazole.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Voriconazole.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Voriconazole.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Voriconazole.Approved, Investigational
ValsartanThe metabolism of Voriconazole can be decreased when combined with Valsartan.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Voriconazole.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Voriconazole.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Voriconazole.Approved
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Voriconazole.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Voriconazole.Approved
VenlafaxineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Venlafaxine.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Voriconazole.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Voriconazole.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Voriconazole.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Voriconazole.Approved
VinblastineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Vinblastine.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Voriconazole.Approved, Investigational
VincristineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Vincristine.Approved, Investigational
VindesineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Vindesine.Approved
VinorelbineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Vinorelbine.Approved, Investigational
VinpocetineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Vinpocetine.Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Voriconazole.Approved
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Voriconazole.Approved
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Voriconazole.Approved
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Voriconazole.Approved
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Voriconazole.Approved, Investigational, Withdrawn
XylometazolineThe risk or severity of adverse effects can be increased when Voriconazole is combined with Xylometazoline.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Voriconazole.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Voriconazole.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Voriconazole.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Voriconazole.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Voriconazole.Approved
ZiconotideThe risk or severity of adverse effects can be increased when Voriconazole is combined with Ziconotide.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Voriconazole.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Voriconazole.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Voriconazole.Approved
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Voriconazole.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Voriconazole.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Voriconazole.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Voriconazole.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Voriconazole.Approved, Investigational
Food InteractionsNot Available
References
Synthesis Reference

Venkataraman Sundaram, Venkata Bhaskara Rao Uppala, Surya Prabhakar Akundi, Venkateswarlu Muvva, Vijayawardhan Chitta, Alekhya Donthula, Manoj Ramesh Kharkar, Surya Narayana Devarakonda, Subba Reddy Peddireddy, “Process For Preparing Voriconazole.” U.S. Patent US20080194820, issued August 14, 2008.

US20080194820
General References
  1. Herbrecht R, Denning DW, Patterson TF, Bennett JE, Greene RE, Oestmann JW, Kern WV, Marr KA, Ribaud P, Lortholary O, Sylvester R, Rubin RH, Wingard JR, Stark P, Durand C, Caillot D, Thiel E, Chandrasekar PH, Hodges MR, Schlamm HT, Troke PF, de Pauw B: Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med. 2002 Aug 8;347(6):408-15. [PubMed:12167683 ]
  2. Patterson TF, Boucher HW, Herbrecht R, Denning DW, Lortholary O, Ribaud P, Rubin RH, Wingard JR, DePauw B, Schlamm HT, Troke P, Bennett JE: Strategy of following voriconazole versus amphotericin B therapy with other licensed antifungal therapy for primary treatment of invasive aspergillosis: impact of other therapies on outcome. Clin Infect Dis. 2005 Nov 15;41(10):1448-52. Epub 2005 Oct 13. [PubMed:16231256 ]
  3. Kullberg BJ, Sobel JD, Ruhnke M, Pappas PG, Viscoli C, Rex JH, Cleary JD, Rubinstein E, Church LW, Brown JM, Schlamm HT, Oborska IT, Hilton F, Hodges MR: Voriconazole versus a regimen of amphotericin B followed by fluconazole for candidaemia in non-neutropenic patients: a randomised non-inferiority trial. Lancet. 2005 Oct 22-28;366(9495):1435-42. [PubMed:16243088 ]
  4. Ally R, Schurmann D, Kreisel W, Carosi G, Aguirrebengoa K, Dupont B, Hodges M, Troke P, Romero AJ: A randomized, double-blind, double-dummy, multicenter trial of voriconazole and fluconazole in the treatment of esophageal candidiasis in immunocompromised patients. Clin Infect Dis. 2001 Nov 1;33(9):1447-54. Epub 2001 Sep 26. [PubMed:11577374 ]
  5. Walsh TJ, Pappas P, Winston DJ, Lazarus HM, Petersen F, Raffalli J, Yanovich S, Stiff P, Greenberg R, Donowitz G, Schuster M, Reboli A, Wingard J, Arndt C, Reinhardt J, Hadley S, Finberg R, Laverdiere M, Perfect J, Garber G, Fioritoni G, Anaissie E, Lee J: Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever. N Engl J Med. 2002 Jan 24;346(4):225-34. [PubMed:11807146 ]
External Links
ATC CodesJ02AC03
AHFS Codes
  • 08:14.08
PDB EntriesNot Available
FDA labelDownload (321 KB)
MSDSDownload (57.2 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9958
Blood Brain Barrier+0.9047
Caco-2 permeable+0.7219
P-glycoprotein substrateSubstrate0.591
P-glycoprotein inhibitor INon-inhibitor0.6113
P-glycoprotein inhibitor IINon-inhibitor0.8195
Renal organic cation transporterNon-inhibitor0.5354
CYP450 2C9 substrateNon-substrate0.727
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.5792
CYP450 1A2 substrateNon-inhibitor0.7491
CYP450 2C9 inhibitorInhibitor0.5203
CYP450 2D6 inhibitorNon-inhibitor0.8315
CYP450 2C19 inhibitorInhibitor0.5784
CYP450 3A4 inhibitorNon-inhibitor0.7011
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.6649
Ames testNon AMES toxic0.7019
CarcinogenicityNon-carcinogens0.776
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.3469 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8791
hERG inhibition (predictor II)Non-inhibitor0.6282
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
Packagers
Dosage forms
FormRouteStrength
Injection, powder, for solutionIntravenous200 mg
Injection, powder, lyophilized, for solutionIntravenous10 mg/mL
Powder, for suspensionOral3 g
Powder, for suspensionOral40 mg/mL
TabletOral200 mg
TabletOral50 mg
Tablet, film coatedOral200 mg/1
Tablet, film coatedOral50 mg/1
Powder, for solutionIntravenous200 mg
Injection, powder, for solutionIntravenous10 mg/mL
SuspensionOral40 mg/mL
TabletOral200 mg/1
TabletOral50 mg/1
Tablet, coatedOral200 mg/1
Tablet, coatedOral50 mg/1
Tablet, film coatedOral200 mg
Tablet, film coatedOral50 mg
Prices
Unit descriptionCostUnit
Vfend 40 mg/ml Suspension 75ml Bottle870.72USD bottle
Vfend iv 200 mg vial143.5USD vial
Vfend 200 mg tablet49.74USD tablet
Vfend 50 mg tablet12.43USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2035314 No2000-01-182011-01-30Canada
CA2295035 No2005-04-192018-06-02Canada
US5116844 No1992-08-112009-08-11Us
US5567817 No1996-05-242016-05-24Us
US6632803 No1998-06-022018-06-02Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point127-130 °CNot Available
water solubilityLowNot Available
logP1Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0978 mg/mLALOGPS
logP1.65ALOGPS
logP1.82ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)12.71ChemAxon
pKa (Strongest Basic)2.27ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area76.72 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity95.28 m3·mol-1ChemAxon
Polarizability30.54 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpropylamines. These are compounds containing a phenylpropylamine moiety, which consists of a phenyl group substituted at the third carbon by an propan-1-amine.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenylpropylamines
Direct ParentPhenylpropylamines
Alternative Parents
Substituents
  • Phenylpropylamine
  • Phenylpropane
  • Halopyrimidine
  • Halobenzene
  • Fluorobenzene
  • Pyrimidine
  • Aryl halide
  • Aryl fluoride
  • Heteroaromatic compound
  • 1,2,4-triazole
  • Tertiary alcohol
  • Azole
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Aromatic alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Alcohol
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Yeast
Pharmacological action
yes
Actions
antagonistinhibitor
General Function:
Sterol 14-demethylase activity
Specific Function:
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name:
ERG11
Uniprot ID:
P10613
Molecular Weight:
60674.965 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Morales IJ, Vohra PK, Puri V, Kottom TJ, Limper AH, Thomas CF Jr: Characterization of a lanosterol 14 alpha-demethylase from Pneumocystis carinii. Am J Respir Cell Mol Biol. 2003 Aug;29(2):232-8. Epub 2003 Feb 26. [PubMed:12606318 ]
  4. Sanguinetti M, Posteraro B, Fiori B, Ranno S, Torelli R, Fadda G: Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance. Antimicrob Agents Chemother. 2005 Feb;49(2):668-79. [PubMed:15673750 ]
  5. Li X, Brown N, Chau AS, Lopez-Ribot JL, Ruesga MT, Quindos G, Mendrick CA, Hare RS, Loebenberg D, DiDomenico B, McNicholas PM: Changes in susceptibility to posaconazole in clinical isolates of Candida albicans. J Antimicrob Chemother. 2004 Jan;53(1):74-80. Epub 2003 Dec 4. [PubMed:14657086 ]
  6. Thompson GR 3rd, Lewis JS 2nd: Pharmacology and clinical use of voriconazole. Expert Opin Drug Metab Toxicol. 2010 Jan;6(1):83-94. doi: 10.1517/17425250903463878. [PubMed:19947892 ]
  7. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
  8. Xu Y, Sheng C, Wang W, Che X, Cao Y, Dong G, Wang S, Ji H, Miao Z, Yao J, Zhang W: Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives. Bioorg Med Chem Lett. 2010 May 1;20(9):2942-5. doi: 10.1016/j.bmcl.2010.03.014. Epub 2010 Mar 7. [PubMed:20362444 ]
  9. Xu J, Cao Y, Zhang J, Yu S, Zou Y, Chai X, Wu Q, Zhang D, Jiang Y, Sun Q: Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives. Eur J Med Chem. 2011 Jul;46(7):3142-8. doi: 10.1016/j.ejmech.2011.02.042. Epub 2011 Feb 24. [PubMed:21420761 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Nadp binding
Specific Function:
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.
Gene Name:
FMO1
Uniprot ID:
Q01740
Molecular Weight:
60310.285 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Trimethylamine monooxygenase activity
Specific Function:
Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds (PubMed:9224773).
Gene Name:
FMO3
Uniprot ID:
P31513
Molecular Weight:
60032.975 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the gener...
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular Weight:
68685.82 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on December 07, 2016 02:38