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IdentificationPharmacologyInteractionsReferencesTrialsEconomicsPropertiesSpectraTaxonomyTioconazole
Targets (2)
Enzymes (8)
Identification
- Name
- Tioconazole
- Accession Number
- DB01007 (APRD01262)
- Type
- Small Molecule
- Groups
- Approved
- Description
Tioconazole is an antifungal medication of the Imidazole class used to treat infections caused by a fungus or yeast. Tioconazole topical (skin) preparations are also available for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability.
- Structure
Structure for DB01007 (Tioconazole)
- Synonyms
- Tioconazol
- Tioconazolum
- External IDs
- Not Available
- Product Ingredients
Ingredient UNII CAS InChI Key Tioconazole hydrochloride T1QKM21KYB 61675-64-7 UKQXXGSDDSCAHA-UHFFFAOYSA-N - Approved Prescription Products
- Not Available
- Approved Generic Prescription Products
- Not Available
- Approved Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End CareOne Tioconazole 1 Ointment 6.5 g/100g Vaginal American Sales Company 2008-01-07 Not applicable US 
Equaline Tioconazole 1 Ointment 6.5 g/100g Vaginal Supervalu 2016-03-08 Not applicable US Equate tioconazole 1 day Ointment 6.5 g/100g Vaginal Walmart Stores 2007-11-01 Not applicable US Good Neighbor Pharmacy Tioconazole 1 Ointment 6.5 g/100g Vaginal Amerisource Bergen 2008-02-20 Not applicable US Gynecure External Cream 1% (refill) Cream 1 % Topical Pfizer Canada Inc., Consumer Healthcare Division Not applicable Not applicable Canada 
Gynecure Vaginal Ointment 6.5% W/w Ointment 6.5 % Vaginal Pfizer Canada Inc., Consumer Healthcare Division 1995-12-31 2002-11-11 Canada Gynecure Vaginal Ovule 300mg Suppository 300 mg Vaginal Pfizer Canada Inc., Consumer Healthcare Division 1995-12-31 2002-08-06 Canada Healthy Accents Tioconazole 1 Ointment 6.5 g/100g Vaginal Dza Brands, 2008-04-06 Not applicable US Image Essentials Tioconazole Treatment Ointment 6.5 g/100g Vaginal Kmart Corporation 2014-12-26 Not applicable US Leader Tioconastat 1 1 Dose Treatment Ointment 6.5 g/100g Vaginal Cardinal Health 2008-04-03 Not applicable US ShopRite Tioconazole 1 Ointment 6.5 g/100g Vaginal Wakfern Food Corporation 2013-09-17 Not applicable US Signature Care Tioconazole 1 Ointment 6.5 g/100g Vaginal Safeway 2015-09-24 Not applicable US Smart Sense Tioconazole 1 Ointment 6.5 g/100g Vaginal Kmart Corporation 2016-06-28 Not applicable US Smart Sense Tioconazole 1 Ointment 6.5 g/100g Vaginal Kmart Corporation 2011-07-11 Not applicable US Sunmark Tioconazole 1 Ointment 6.5 g/100g Vaginal Mc Kesson 2007-12-18 Not applicable US Tioconazole Ointment 6.5 g/100g Vaginal Hyvee 2008-03-03 Not applicable US Tioconazole 1 Ointment 6.5 g/100g Vaginal Meijer Distribution 2008-01-09 Not applicable US Tioconazole 1 Ointment 6.5 g/100g Vaginal H.E.B. 2016-05-09 Not applicable US Tioconazole 1 Ointment 6.5 g/100g Vaginal Walgreen 2007-12-19 Not applicable US Tioconazole 1 Ointment 6.5 g/100g Vaginal Western Family Foods 2016-06-01 Not applicable US Tioconazole 1 Ointment 6.5 g/100g Vaginal Cvs Health 2015-11-12 Not applicable US Tioconazole 1 1 Dose Treatment Ointment 6.5 g/100g Vaginal Rite Aid 2007-12-13 Not applicable US Tioconazole 1 Day Ointment 300 mg/g Topical Insight Pharmaceuticals 2001-11-21 Not applicable US Tioconazole Ointment 6.5% Ointment 65 mg/g Vaginal DPT Laboratories, Ltd. 2007-08-22 Not applicable US Topcare Tioconazole 1 Ointment 6.5 g/100g Vaginal Topco Associates 2008-03-03 Not applicable US Trosyd AF Cream 1% Cream 1 % Topical Pfizer Canada Inc., Consumer Healthcare Division 1987-12-31 2002-02-01 Canada Trosyd J Cream 1% W/w Cream 10 mg Topical Pfizer Canada Inc., Consumer Healthcare Division 1997-03-27 2002-08-06 Canada Up and up tioconazole 1 Ointment 6.5 g/100g Vaginal Target Corporation. 2009-07-08 Not applicable US Vagistat-1 Ointment 300 mg/1 Vaginal Novartis 1997-02-11 2016-12-07 US - Unapproved/Other Products
- Not Available
- International/Other Brands
- GyneCure / Monistat 1 / Trosyd / Trosyl / Vagistat-1
- Brand mixtures
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Gynecure Com.pk.vag Ont6.5%vulvar Crm1% W/w Cream; Ointment Topical; Vaginal Pfizer Canada Inc., Consumer Healthcare Division 1995-12-31 1997-08-12 Canada Gynecure Com.pk.vag Ovule300mg Vulv.crm1%w/w Cream; Suppository Topical; Vaginal Pfizer Canada Inc., Consumer Healthcare Division 1995-12-31 1997-08-12 Canada Gynecure Tandempk.vag Ont6.5%/vulv.crm1%-w/w Cream; Ointment Topical; Vaginal Pfizer Canada Inc., Consumer Healthcare Division 1997-03-27 2002-11-11 Canada Gynecure Tandempk.vag Ov.300mg/vulv.crm1%w/w Cream; Suppository Topical; Vaginal Pfizer Canada Inc., Consumer Healthcare Division 1996-12-02 2002-11-11 Canada - Categories
- 14-alpha Demethylase Inhibitors
- Anti-Infective Agents
- Antifungal Agents
- Antifungal Agents (Vaginal)
- Antifungals for Dermatological Use
- Antifungals for Topical Use
- Azole Antifungals
- Chemically-Induced Disorders
- Cytochrome P-450 CYP1A2 Inhibitors
- Cytochrome P-450 CYP1A2 Inhibitors (weak)
- Cytochrome P-450 CYP2C19 Inhibitors
- Cytochrome P-450 CYP2C8 Inhibitors
- Cytochrome P-450 CYP2C9 Inhibitors
- Cytochrome P-450 CYP2D6 Inhibitors
- Cytochrome P-450 CYP2D6 Inhibitors (weak)
- Cytochrome P-450 CYP2E1 Inhibitors
- Cytochrome P-450 CYP3A Inhibitors
- Cytochrome P-450 CYP3A4 Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Dermatologicals
- Enzyme Inhibitors
- Hormone Antagonists
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Imidazole and Triazole Derivatives
- Steroid Synthesis Inhibitors
- UNII
- S57Y5X1117
- CAS number
- 65899-73-2
- Weight
- Average: 387.711
Monoisotopic: 385.981416859 - Chemical Formula
- C16H13Cl3N2OS
- InChI Key
- QXHHHPZILQDDPS-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
- IUPAC Name
- 1-{2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
- SMILES
- ClC1=C(COC(CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=CS1
Pharmacology
- Indication
For the local treatment of vulvovaginal candidiasis (moniliasis).
- Structured Indications
- Pharmacodynamics
Tioconazole is a broad-spectrum imidazole antifungal agent that inhibits the growth of human pathogenic yeasts. Tioconazole exhibits fungicidal activity in vitro against Candida albicans, other species of the genus Candida, and against Torulopsis glabrata. Tioconazole prevents the growth and function of some fungal organisms by interfering with the production of substances needed to preserve the cell membrane. This drug is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.
- Mechanism of action
Tioconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Tioconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel.
Target Actions Organism ALanosterol 14-alpha demethylase antagonistYeast ULanosterol 14-alpha demethylase inhibitorHuman - Absorption
Systemic absorption following a single intravaginal application of tioconazole in nonpregnant patients is negligible.
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
Orally administered tioconazole is extensively metabolized. The major metabolites are glucuronide conjugates.
- Route of elimination
- Not Available
- Half life
- Not Available
- Clearance
- Not Available
- Toxicity
Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.
- Affected organisms
- Yeast and other fungi
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
Drug Interaction Drug group Amlodipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Amlodipine. Approved Amodiaquine The serum concentration of Amodiaquine can be increased when it is combined with Tioconazole. Approved Amphotericin B The therapeutic efficacy of Amphotericin B can be decreased when used in combination with Tioconazole. Approved, Investigational Amrinone The risk or severity of adverse effects can be increased when Tioconazole is combined with Amrinone. Approved Aripiprazole The serum concentration of Aripiprazole can be increased when it is combined with Tioconazole. Approved, Investigational Azelnidipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Azelnidipine. Approved Azimilide The risk or severity of adverse effects can be increased when Tioconazole is combined with Azimilide. Investigational Barnidipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Barnidipine. Approved Benidipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Benidipine. Approved Bepridil The risk or severity of adverse effects can be increased when Tioconazole is combined with Bepridil. Approved, Withdrawn Buspirone The metabolism of Buspirone can be decreased when combined with Tioconazole. Approved, Investigational Busulfan The serum concentration of Busulfan can be increased when it is combined with Tioconazole. Approved, Investigational Carboxyamidotriazole The risk or severity of adverse effects can be increased when Tioconazole is combined with Cai. Investigational Cilnidipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Cilnidipine. Approved Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Tioconazole. Approved Cinnarizine The risk or severity of adverse effects can be increased when Tioconazole is combined with Cinnarizine. Approved Cisapride The serum concentration of Cisapride can be increased when it is combined with Tioconazole. Approved, Investigational, Withdrawn Clevidipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Clevidipine. Approved Conivaptan The metabolism of Conivaptan can be decreased when combined with Tioconazole. Approved, Investigational Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Tioconazole. Approved, Investigational, Vet Approved Darodipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Darodipine. Experimental Didanosine Didanosine can cause a decrease in the absorption of Tioconazole resulting in a reduced serum concentration and potentially a decrease in efficacy. Approved Diltiazem The risk or severity of adverse effects can be increased when Tioconazole is combined with Diltiazem. Approved Docetaxel The metabolism of Docetaxel can be decreased when combined with Tioconazole. Approved, Investigational Dofetilide The metabolism of Dofetilide can be decreased when combined with Tioconazole. Approved Dotarizine The risk or severity of adverse effects can be increased when Tioconazole is combined with Dotarizine. Investigational Efonidipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Efonidipine. Approved Eperisone The risk or severity of adverse effects can be increased when Tioconazole is combined with Eperisone. Approved, Investigational Etravirine The serum concentration of Etravirine can be increased when it is combined with Tioconazole. Approved Felodipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Felodipine. Approved, Investigational Fendiline The risk or severity of adverse effects can be increased when Tioconazole is combined with Fendiline. Withdrawn Flunarizine The risk or severity of adverse effects can be increased when Tioconazole is combined with Flunarizine. Approved Fosphenytoin The serum concentration of Tioconazole can be decreased when it is combined with Fosphenytoin. Approved Gabapentin The risk or severity of adverse effects can be increased when Tioconazole is combined with Gabapentin. Approved, Investigational Gallopamil The risk or severity of adverse effects can be increased when Tioconazole is combined with Gallopamil. Investigational Isradipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Isradipine. Approved Lacidipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Lacidipine. Approved Lamotrigine The risk or severity of adverse effects can be increased when Tioconazole is combined with Lamotrigine. Approved, Investigational Lercanidipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Lercanidipine. Approved, Investigational Losartan The metabolism of Losartan can be decreased when combined with Tioconazole. Approved Magnesium Sulfate The risk or severity of adverse effects can be increased when Tioconazole is combined with Magnesium Sulfate. Approved, Vet Approved Manidipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Manidipine. Approved Mibefradil The risk or severity of adverse effects can be increased when Tioconazole is combined with Mibefradil. Withdrawn Naftopidil The risk or severity of adverse effects can be increased when Tioconazole is combined with Naftopidil. Investigational Nicardipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Nicardipine. Approved Nifedipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Nifedipine. Approved Niguldipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Niguldipine. Experimental Niludipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Niludipine. Experimental Nilvadipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Nilvadipine. Approved Nimesulide The risk or severity of adverse effects can be increased when Tioconazole is combined with Nimesulide. Approved, Withdrawn Nimodipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Nimodipine. Approved Nisoldipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Nisoldipine. Approved Nitrendipine The risk or severity of adverse effects can be increased when Tioconazole is combined with Nitrendipine. Approved Perhexiline The risk or severity of adverse effects can be increased when Tioconazole is combined with Perhexiline. Approved Phenytoin The serum concentration of Phenytoin can be increased when it is combined with Tioconazole. Approved, Vet Approved Pimozide Tioconazole may increase the arrhythmogenic activities of Pimozide. Approved Pinaverium The risk or severity of adverse effects can be increased when Tioconazole is combined with Pinaverium. Approved Pregabalin The risk or severity of adverse effects can be increased when Tioconazole is combined with Pregabalin. Approved, Illicit, Investigational Prenylamine The risk or severity of adverse effects can be increased when Tioconazole is combined with Prenylamine. Withdrawn Progesterone The therapeutic efficacy of Progesterone can be decreased when used in combination with Tioconazole. Approved, Vet Approved Quinidine The metabolism of Quinidine can be decreased when combined with Tioconazole. Approved Ranolazine The metabolism of Ranolazine can be decreased when combined with Tioconazole. Approved, Investigational Rifabutin The serum concentration of Rifabutin can be increased when it is combined with Tioconazole. Approved Rifampicin The serum concentration of Rifampicin can be increased when it is combined with Tioconazole. Approved Rifapentine The serum concentration of Rifapentine can be increased when it is combined with Tioconazole. Approved Risedronate The risk or severity of adverse effects can be increased when Tioconazole is combined with Risedronate. Approved, Investigational Solifenacin The metabolism of Solifenacin can be decreased when combined with Tioconazole. Approved Sucralfate Sucralfate can cause a decrease in the absorption of Tioconazole resulting in a reduced serum concentration and potentially a decrease in efficacy. Approved Sunitinib The metabolism of Sunitinib can be decreased when combined with Tioconazole. Approved, Investigational Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Tioconazole. Approved, Investigational Tizanidine The serum concentration of Tizanidine can be increased when it is combined with Tioconazole. Approved Tolfenamic Acid The risk or severity of adverse effects can be increased when Tioconazole is combined with Tolfenamic Acid. Approved Tranilast The risk or severity of adverse effects can be increased when Tioconazole is combined with Tranilast. Approved, Investigational Verapamil The risk or severity of adverse effects can be increased when Tioconazole is combined with Verapamil. Approved Vinpocetine The risk or severity of adverse effects can be increased when Tioconazole is combined with Vinpocetine. Investigational Xylometazoline The risk or severity of adverse effects can be increased when Tioconazole is combined with Xylometazoline. Approved Ziconotide The risk or severity of adverse effects can be increased when Tioconazole is combined with Ziconotide. Approved Zolpidem The serum concentration of Zolpidem can be increased when it is combined with Tioconazole. Approved - Food Interactions
- Not Available
References
- Synthesis Reference
- Not Available
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB15142
- KEGG Drug
- D00890
- KEGG Compound
- C08082
- PubChem Compound
- 5482
- PubChem Substance
- 46508604
- ChemSpider
- 5282
- BindingDB
- 50370218
- ChEBI
- 77898
- ChEMBL
- CHEMBL1200438
- Therapeutic Targets Database
- DAP001268
- PharmGKB
- PA164746156
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Tioconazole
- ATC Codes
- G01AF08 — Tioconazole
- G01AF — Imidazole derivatives
- G01A — ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
- G01 — GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
- G — GENITO URINARY SYSTEM AND SEX HORMONES
- AHFS Codes
- Not Available
- PDB Entries
- Not Available
- FDA label
- Download (784 KB)
- MSDS
- Not Available
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Pfizer laboratories div pfizer inc
- L perrigo co
- Novartis consumer health inc
- Packagers
- Dosage forms
Form Route Strength Cream; ointment Topical; Vaginal Cream; suppository Topical; Vaginal Ointment Vaginal 6.5 % Suppository Vaginal 300 mg Ointment Vaginal 6.5 g/100g Ointment Topical 300 mg/g Ointment Vaginal 65 mg/g Cream Topical 1 % Cream Topical 10 mg Ointment Vaginal 300 mg/1 - Prices
Unit description Cost Unit Monistat-Derm 2% Cream 28.35 gm Tube 41.99USD tube Monistat-Derm 2% Cream 15 gm Tube 32.0USD tube Monistat 1 combination pack 16.81USD each Monistat 1 6.5% ointment 3.6USD g Vagistat-1 6.5% ointment 3.6USD g Tioconazole 1 6.5% ointment 1.75USD g DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source logP 4.4 Not Available - Predicted Properties
Property Value Source Water Solubility 0.0165 mg/mL ALOGPS logP 4.86 ALOGPS logP 5.3 ChemAxon logS -4.4 ALOGPS pKa (Strongest Basic) 6.77 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 2 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 27.05 Å2 ChemAxon Rotatable Bond Count 6 ChemAxon Refractivity 94.53 m3·mol-1 ChemAxon Polarizability 36.84 Å3 ChemAxon Number of Rings 3 ChemAxon Bioavailability 1 ChemAxon Rule of Five No ChemAxon Ghose Filter Yes ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule Yes ChemAxon - Predicted ADMET features
Property Value Probability Human Intestinal Absorption + 0.966 Blood Brain Barrier + 0.9814 Caco-2 permeable + 0.5812 P-glycoprotein substrate Non-substrate 0.5819 P-glycoprotein inhibitor I Non-inhibitor 0.911 P-glycoprotein inhibitor II Non-inhibitor 0.5295 Renal organic cation transporter Inhibitor 0.5164 CYP450 2C9 substrate Non-substrate 0.8248 CYP450 2D6 substrate Non-substrate 0.9116 CYP450 3A4 substrate Non-substrate 0.7558 CYP450 1A2 substrate Inhibitor 0.946 CYP450 2C9 inhibitor Inhibitor 0.8757 CYP450 2D6 inhibitor Inhibitor 0.9032 CYP450 2C19 inhibitor Inhibitor 0.926 CYP450 3A4 inhibitor Inhibitor 0.8406 CYP450 inhibitory promiscuity High CYP Inhibitory Promiscuity 0.9934 Ames test Non AMES toxic 0.8092 Carcinogenicity Non-carcinogens 0.8543 Biodegradation Not ready biodegradable 0.9869 Rat acute toxicity 2.7335 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.7187 hERG inhibition (predictor II) Inhibitor 0.6506
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Taxonomy
- Description
- This compound belongs to the class of chemical entities known as benzylethers. These are aromatic ethers with the general formula ROCR' (R = alkyl, aryl; R'=benzene).
- Kingdom
- Chemical entities
- Super Class
- Organic compounds
- Class
- Benzenoids
- Sub Class
- Benzene and substituted derivatives
- Direct Parent
- Benzylethers
- Alternative Parents
- Dichlorobenzenes / N-substituted imidazoles / Aryl chlorides / Thiophenes / Heteroaromatic compounds / Dialkyl ethers / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds / Organochlorides show 1 more
- Substituents
- Benzylether / 1,3-dichlorobenzene / Chlorobenzene / Halobenzene / Aryl chloride / Aryl halide / N-substituted imidazole / Azole / Heteroaromatic compound / Thiophene show 14 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- imidazoles, thiophenes, ether, dichlorobenzene (CHEBI:77898 )
Targets
- Kind
- Protein
- Organism
- Yeast
- Pharmacological action
- Yes
- Actions
- Antagonist
- General Function
- Sterol 14-demethylase activity
- Specific Function
- Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
- Gene Name
- ERG11
- Uniprot ID
- P10613
- Uniprot Name
- Lanosterol 14-alpha demethylase
- Molecular Weight
- 60674.965 Da
References
- Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
- Ballard SA, Lodola A, Tarbit MH: A comparative study of 1-substituted imidazole and 1,2,4-triazole antifungal compounds as inhibitors of testosterone hydroxylations catalysed by mouse hepatic microsomal cytochromes P-450. Biochem Pharmacol. 1988 Dec 15;37(24):4643-51. [PubMed:3202901 ]
- Fliri AF, Loging WT, Thadeio PF, Volkmann RA: Biological spectra analysis: Linking biological activity profiles to molecular structure. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):261-6. Epub 2004 Dec 29. [PubMed:15625110 ]
- Bellamine A, Lepesheva GI, Waterman MR: Fluconazole binding and sterol demethylation in three CYP51 isoforms indicate differences in active site topology. J Lipid Res. 2004 Nov;45(11):2000-7. Epub 2004 Aug 16. [PubMed:15314102 ]
- Guinea J, Sanchez-Somolinos M, Cuevas O, Pelaez T, Bouza E: Fluconazole resistance mechanisms in Candida krusei: the contribution of efflux-pumps. Med Mycol. 2006 Sep;44(6):575-8. [PubMed:16966178 ]
- Chau AS, Chen G, McNicholas PM, Mann PA: Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae. Antimicrob Agents Chemother. 2006 Nov;50(11):3917-9. Epub 2006 Sep 11. [PubMed:16966400 ]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Sterol 14-demethylase activity
- Specific Function
- Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
- Gene Name
- CYP51A1
- Uniprot ID
- Q16850
- Uniprot Name
- Lanosterol 14-alpha demethylase
- Molecular Weight
- 56805.26 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
- Fliri AF, Loging WT, Thadeio PF, Volkmann RA: Biological spectra analysis: Linking biological activity profiles to molecular structure. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):261-6. Epub 2004 Dec 29. [PubMed:15625110 ]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Enzymes
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Oxygen binding
- Specific Function
- Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
- Gene Name
- CYP19A1
- Uniprot ID
- P11511
- Uniprot Name
- Aromatase
- Molecular Weight
- 57882.48 Da
References
- Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP1A2
- Uniprot ID
- P05177
- Uniprot Name
- Cytochrome P450 1A2
- Molecular Weight
- 58293.76 Da
References
- Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Steroid hydroxylase activity
- Specific Function
- Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
- Gene Name
- CYP2C19
- Uniprot ID
- P33261
- Uniprot Name
- Cytochrome P450 2C19
- Molecular Weight
- 55930.545 Da
References
- Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Steroid hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP2C8
- Uniprot ID
- P10632
- Uniprot Name
- Cytochrome P450 2C8
- Molecular Weight
- 55824.275 Da
References
- Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Steroid hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP2C9
- Uniprot ID
- P11712
- Uniprot Name
- Cytochrome P450 2C9
- Molecular Weight
- 55627.365 Da
References
- Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Steroid hydroxylase activity
- Specific Function
- Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic ...
- Gene Name
- CYP2E1
- Uniprot ID
- P05181
- Uniprot Name
- Cytochrome P450 2E1
- Molecular Weight
- 56848.42 Da
References
- Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- CYP3A4
- Uniprot ID
- P08684
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
References
- Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Steroid hydroxylase activity
- Specific Function
- Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
- Gene Name
- CYP2D6
- Uniprot ID
- P10635
- Uniprot Name
- Cytochrome P450 2D6
- Molecular Weight
- 55768.94 Da
Drug created on June 13, 2005 07:24 / Updated on September 01, 2017 10:35