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Identification
NameItraconazole
Accession NumberDB01167  (APRD00040)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionOne of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis. [PubChem]
Structure
Thumb
Synonyms
Itraconazol
Itraconazole
Itraconazolum
Itrizole (tn)
Oriconazole
Sporanox (tn)
External Identifiers
  • R51211
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ItraconazoleCapsule100 mg/1OralCarilion Materials Management2005-02-01Not applicableUs
ItraconazoleCapsule100 mg/1OralPatriot Pharmaceuticals2005-02-01Not applicableUs
OnmelTablet200 mg/1OralMerz Pharmaceuticals, LLC2012-11-01Not applicableUs
SporanoxCapsule100 mg/1Oralbryant ranch prepack1992-09-11Not applicableUs
SporanoxCapsule100 mg/1OralJanssen Pharmaceuticals, Inc.1992-09-11Not applicableUs
SporanoxCapsule100 mgOralJanssen Inc1993-12-31Not applicableCanada
SporanoxSolution10 mg/mLOralJanssen Pharmaceuticals, Inc.1997-02-21Not applicableUs
Sporanox Oral Solution 10mg/mlSolution10 mgOralJanssen Inc1997-07-28Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ItraconazoleCapsule100 mg/1OralEon Labs, Inc.2004-05-28Not applicableUs
ItraconazoleCapsule100 mg/1OralMylan Pharmaceuticals Inc.2012-07-20Not applicableUs
ItraconazoleCapsule100 mg/1OralAmneal Pharmaceuticals of New York, LLC2016-09-27Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
ItrizoleNot Available
OriconazoleNot Available
SporalNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII304NUG5GF4
CAS number84625-61-6
WeightAverage: 705.633
Monoisotopic: 704.239307158
Chemical FormulaC35H38Cl2N8O4
InChI KeyVHVPQPYKVGDNFY-ZPGVKDDISA-N
InChI
InChI=1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1
IUPAC Name
1-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
SMILES
CCC(C)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(OC[[email protected]]2CO[C@@](CN3C=NC=N3)(O2)C2=C(Cl)C=C(Cl)C=C2)C=C1
Pharmacology
IndicationFor the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
Structured Indications
PharmacodynamicsItraconazole is an imidazole/triazole type antifungal agent. Itraconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis. The subsequent loss of normal sterols correlates with the accumulation of 14 α-methyl sterols in fungi and may be partly responsible for the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Itraconazole exhibits in vitro activity against Cryptococcus neoformans and Candida spp. Fungistatic activity has also been demonstrated in normal and immunocompromised animal models for systemic and intracranial fungal infections due to Cryptococcus neoformans and for systemic infections due to Candida albicans.
Mechanism of actionItraconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Itraconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
TargetKindPharmacological actionActionsOrganismUniProt ID
Lanosterol 14-alpha demethylaseProteinyes
inhibitor
YeastP50859 details
Lanosterol 14-alpha demethylaseProteinyes
inhibitor
HumanQ16850 details
Related Articles
AbsorptionThe absolute oral bioavailability of itraconazole is 55%, and is maximal when taken with a full meal.
Volume of distribution
  • 796 ± 185 L
Protein binding99.8%
Metabolism

Itraconazole is extensively metabolized by the liver into a large number of metabolites, including hydroxyitraconazole, the major metabolite. The main metabolic pathways are oxidative scission of the dioxolane ring, aliphatic oxidation at the 1-methylpropyl substituent, N-dealkylation of this 1-methylpropyl substituent, oxidative degradation of the piperazine ring and triazolone scission.

SubstrateEnzymesProduct
Itraconazole
hydroxyitraconazoleDetails
Route of eliminationItraconazole is metabolized predominately by the cytochrome P450 3A4 isoenzyme system (CYP3A4) in the liver, resulting in the formation of several metabolites, including hydroxyitraconazole, the major metabolite. Fecal excretion of the parent drug varies between 3-18% of the dose. Renal excretion of the parent drug is less than 0.03% of the dose. About 40% of the dose is excreted as inactive metabolites in the urine. No single excreted metabolite represents more than 5% of a dose.
Half life21 hours
Clearance
  • 381 +/- 95 mL/minute [IV administration]
ToxicityNo significant lethality was observed when itraconazole was administered orally to mice and rats at dosage levels of 320 mg/kg or to dogs at 200 mg/kg.
Affected organisms
  • Fungi, yeast and protozoans
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Itraconazole.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Itraconazole.Experimental, Illicit
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Itraconazole.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Itraconazole.Experimental, Illicit
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Itraconazole.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Itraconazole.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Itraconazole.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Itraconazole.Approved
AcetyldigitoxinThe serum concentration of Acetyldigitoxin can be increased when it is combined with Itraconazole.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Itraconazole.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Itraconazole.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Itraconazole.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Itraconazole.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Itraconazole.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Itraconazole.Experimental
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Itraconazole.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Itraconazole.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Itraconazole.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Itraconazole.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Itraconazole.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Itraconazole.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Itraconazole.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Itraconazole.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Itraconazole.Approved, Illicit, Investigational
Aluminum hydroxideThe serum concentration of Itraconazole can be decreased when it is combined with Aluminum hydroxide.Approved
Aluminum phosphateThe serum concentration of Itraconazole can be decreased when it is combined with Aluminum phosphate.Approved
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Itraconazole.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Itraconazole.Approved
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Itraconazole.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Itraconazole.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Itraconazole.Approved
AmiodaroneThe metabolism of Itraconazole can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Itraconazole.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Itraconazole.Approved
Amphotericin BThe therapeutic efficacy of Amphotericin B can be decreased when used in combination with Itraconazole.Approved, Investigational
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Itraconazole.Approved
AmrinoneThe risk or severity of adverse effects can be increased when Itraconazole is combined with Amrinone.Approved
AnagrelideItraconazole may increase the QTc-prolonging activities of Anagrelide.Approved
AnecortaveThe serum concentration of Anecortave can be increased when it is combined with Itraconazole.Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Itraconazole.Approved
AnvirzelThe serum concentration of Anvirzel can be increased when it is combined with Itraconazole.Investigational
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Itraconazole.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Itraconazole.Approved, Investigational
AprepitantThe serum concentration of Itraconazole can be increased when it is combined with Aprepitant.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Itraconazole.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Itraconazole.Approved, Investigational
Arsenic trioxideItraconazole may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Itraconazole.Approved
AsenapineThe serum concentration of Itraconazole can be decreased when it is combined with Asenapine.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Itraconazole.Approved, Withdrawn
AtazanavirThe metabolism of Itraconazole can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Itraconazole.Approved
AtomoxetineThe metabolism of Itraconazole can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Itraconazole.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Itraconazole.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Itraconazole.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Itraconazole.Approved
AzelnidipineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Azelnidipine.Approved
AzimilideThe risk or severity of adverse effects can be increased when Itraconazole is combined with Azimilide.Investigational
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Itraconazole.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Itraconazole.Investigational
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Itraconazole.Approved
BeclomethasoneThe serum concentration of Beclomethasone can be increased when it is combined with Itraconazole.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Itraconazole.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Itraconazole.Approved
BenidipineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Benidipine.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Itraconazole.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Itraconazole.Approved
BepridilThe risk or severity of adverse effects can be increased when Itraconazole is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Itraconazole.Approved, Vet Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Itraconazole.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Itraconazole.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Itraconazole.Approved
Bismuth SubcitrateThe serum concentration of Itraconazole can be decreased when it is combined with Bismuth Subcitrate.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Itraconazole.Approved
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Itraconazole.Approved
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Itraconazole.Approved, Investigational
BosentanThe serum concentration of Itraconazole can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Itraconazole.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Itraconazole.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Itraconazole.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Itraconazole.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Itraconazole.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Itraconazole.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Itraconazole.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Itraconazole.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Itraconazole.Approved
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Itraconazole.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Itraconazole.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Itraconazole.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Itraconazole.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Itraconazole.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Itraconazole.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Itraconazole.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Itraconazole.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Itraconazole.Approved
CaiThe risk or severity of adverse effects can be increased when Itraconazole is combined with Cai.Investigational
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Itraconazole.Approved, Nutraceutical
Calcium carbonateThe serum concentration of Itraconazole can be decreased when it is combined with Calcium carbonate.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Itraconazole.Experimental
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Itraconazole.Approved
CarbamazepineThe serum concentration of Itraconazole can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Itraconazole.Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Itraconazole.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Itraconazole.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Itraconazole.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Itraconazole.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Itraconazole.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Itraconazole.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Itraconazole.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Itraconazole.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Itraconazole.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Itraconazole.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Itraconazole.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Itraconazole.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Itraconazole.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Itraconazole.Approved, Vet Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Itraconazole.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Itraconazole.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Itraconazole.Approved, Investigational
CilnidipineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Cilnidipine.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Itraconazole.Approved
CimetidineThe serum concentration of Itraconazole can be decreased when it is combined with Cimetidine.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Itraconazole.Approved
CinnarizineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Cinnarizine.Approved
CiprofloxacinItraconazole may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Itraconazole.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Itraconazole.Approved
CitalopramThe metabolism of Citalopram can be decreased when combined with Itraconazole.Approved
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Itraconazole.Approved
ClemastineThe metabolism of Itraconazole can be decreased when combined with Clemastine.Approved
ClevidipineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Clevidipine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Itraconazole.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Itraconazole.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be increased when it is combined with Itraconazole.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Itraconazole.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Itraconazole.Approved
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Itraconazole.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Itraconazole.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Itraconazole.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Itraconazole.Approved, Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Itraconazole.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Itraconazole.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Itraconazole.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Itraconazole.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Itraconazole.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Itraconazole.Approved, Illicit
ClotrimazoleThe metabolism of Itraconazole can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Itraconazole.Approved
CobicistatThe serum concentration of Cobicistat can be increased when it is combined with Itraconazole.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Itraconazole.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Itraconazole.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Itraconazole.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Itraconazole.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Itraconazole.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Itraconazole.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Itraconazole.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Itraconazole.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Itraconazole.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Itraconazole.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Itraconazole.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Itraconazole.Approved, Investigational
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Itraconazole.Approved
DabrafenibThe serum concentration of Itraconazole can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Itraconazole.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Itraconazole.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Itraconazole.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Itraconazole.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Itraconazole.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Itraconazole.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Itraconazole.Approved, Investigational
DarodipineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Darodipine.Experimental
DarunavirThe serum concentration of Itraconazole can be increased when it is combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Itraconazole.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Itraconazole.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Itraconazole.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Itraconazole.Approved
DeferasiroxThe serum concentration of Itraconazole can be decreased when it is combined with Deferasirox.Approved, Investigational
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Itraconazole.Investigational
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Itraconazole.Approved
DeslanosideThe serum concentration of Deslanoside can be increased when it is combined with Itraconazole.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Itraconazole.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Itraconazole.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Itraconazole.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Itraconazole.Approved
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Itraconazole.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Itraconazole.Vet Approved
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Itraconazole.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Itraconazole.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Itraconazole.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Itraconazole.Approved, Vet Approved
DicoumarolThe serum concentration of Dicoumarol can be increased when it is combined with Itraconazole.Approved
DidanosineDidanosine can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DienogestThe serum concentration of Dienogest can be increased when it is combined with Itraconazole.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Itraconazole.Approved
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Itraconazole.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Itraconazole.Approved
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Itraconazole.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Itraconazole.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Itraconazole.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Itraconazole.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Itraconazole.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Itraconazole.Illicit
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Itraconazole.Approved
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Itraconazole.Approved
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Itraconazole.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Itraconazole.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Itraconazole.Approved, Investigational
DofetilideThe metabolism of Dofetilide can be decreased when combined with Itraconazole.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Itraconazole.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Itraconazole.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Itraconazole.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Itraconazole.Approved
DotarizineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Dotarizine.Investigational
DoxepinThe serum concentration of Itraconazole can be decreased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Itraconazole.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Itraconazole.Approved, Investigational
DoxycyclineThe metabolism of Itraconazole can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Itraconazole.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Itraconazole.Approved
DroperidolItraconazole may increase the QTc-prolonging activities of Droperidol.Approved, Vet Approved
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Itraconazole.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Itraconazole.Approved, Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Itraconazole.Approved
EfavirenzThe serum concentration of Itraconazole can be decreased when it is combined with Efavirenz.Approved, Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Efonidipine.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Itraconazole.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Itraconazole.Approved
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Itraconazole.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Itraconazole.Approved, Vet Approved
EnzalutamideThe serum concentration of Itraconazole can be decreased when it is combined with Enzalutamide.Approved
EperisoneThe risk or severity of adverse effects can be increased when Itraconazole is combined with Eperisone.Approved, Investigational
EpinastineThe serum concentration of Itraconazole can be decreased when it is combined with Epinastine.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Itraconazole.Approved
EquileninThe serum concentration of Equilenin can be increased when it is combined with Itraconazole.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Itraconazole.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Itraconazole.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Itraconazole.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Itraconazole.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Itraconazole.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Itraconazole.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Itraconazole.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Itraconazole.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Itraconazole can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsomeprazoleThe serum concentration of Itraconazole can be decreased when it is combined with Esomeprazole.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Itraconazole.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Itraconazole.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Itraconazole.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Itraconazole.Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Itraconazole.Approved, Vet Approved
EstroneThe metabolism of Estrone can be decreased when combined with Itraconazole.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Itraconazole.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Itraconazole.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Itraconazole.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Itraconazole.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Itraconazole.Approved
Ethyl biscoumacetateThe serum concentration of Ethyl biscoumacetate can be increased when it is combined with Itraconazole.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Itraconazole.Approved, Illicit
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Itraconazole.Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Itraconazole.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Itraconazole.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Itraconazole.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Itraconazole.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Itraconazole.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Itraconazole.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Itraconazole.Approved
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Itraconazole.Approved
FamotidineThe serum concentration of Itraconazole can be decreased when it is combined with Famotidine.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Itraconazole.Approved
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Itraconazole.Approved, Investigational
FendilineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Fendiline.Withdrawn
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Itraconazole.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Itraconazole.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Itraconazole.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Itraconazole.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Itraconazole.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Itraconazole.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Itraconazole.Approved, Investigational
FlecainideItraconazole may increase the QTc-prolonging activities of Flecainide.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Itraconazole.Approved
fluasteroneThe serum concentration of fluasterone can be increased when it is combined with Itraconazole.Investigational
FluconazoleThe metabolism of Itraconazole can be decreased when combined with Fluconazole.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Itraconazole.Approved
FluindioneThe serum concentration of Fluindione can be increased when it is combined with Itraconazole.Investigational
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Itraconazole.Approved, Vet Approved
FlunarizineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Flunarizine.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Itraconazole.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Itraconazole.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Itraconazole.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Itraconazole.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Itraconazole.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Itraconazole.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Itraconazole.Approved, Vet Approved
FlupentixolItraconazole may increase the QTc-prolonging activities of Flupentixol.Approved, Withdrawn
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Itraconazole.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Itraconazole.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Itraconazole.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Itraconazole.Approved, Illicit
FlutamideThe metabolism of Flutamide can be decreased when combined with Itraconazole.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Itraconazole.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Itraconazole.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Itraconazole.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Itraconazole.Approved
FluvoxamineThe metabolism of Itraconazole can be decreased when combined with Fluvoxamine.Approved, Investigational
FormestaneThe serum concentration of Formestane can be increased when it is combined with Itraconazole.Approved, Investigational, Withdrawn
FosamprenavirThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Itraconazole.Approved
FosaprepitantThe serum concentration of Itraconazole can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Itraconazole can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Itraconazole.Approved, Investigational
Fusidic AcidThe serum concentration of Itraconazole can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Itraconazole is combined with Gabapentin.Approved, Investigational
Gadobenic acidItraconazole may increase the QTc-prolonging activities of Gadobenic acid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Itraconazole.Approved
GallopamilThe risk or severity of adverse effects can be increased when Itraconazole is combined with Gallopamil.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Itraconazole.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Itraconazole.Approved
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Itraconazole.Approved
GemifloxacinItraconazole may increase the QTc-prolonging activities of Gemifloxacin.Approved, Investigational
GlipizideThe metabolism of Glipizide can be decreased when combined with Itraconazole.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Itraconazole.Approved
GoserelinItraconazole may increase the QTc-prolonging activities of Goserelin.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Itraconazole.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Itraconazole.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Itraconazole.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Itraconazole.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Itraconazole.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Itraconazole.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Itraconazole.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be increased when it is combined with Itraconazole.Investigational
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Itraconazole.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Itraconazole.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Itraconazole.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Itraconazole.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Itraconazole.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Itraconazole.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Itraconazole.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Itraconazole.Approved
IbutilideItraconazole may increase the QTc-prolonging activities of Ibutilide.Approved
IdelalisibThe serum concentration of Itraconazole can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Itraconazole resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Itraconazole.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Itraconazole.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Itraconazole.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Itraconazole.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Itraconazole.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Itraconazole.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Itraconazole.Approved
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Itraconazole.Approved
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Itraconazole.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Itraconazole.Approved
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Itraconazole.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Itraconazole.Approved, Investigational
IsoniazidThe serum concentration of Itraconazole can be decreased when it is combined with Isoniazid.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Itraconazole.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Itraconazole.Approved
IsradipineThe metabolism of Isradipine can be decreased when combined with Itraconazole.Approved
IstaroximeThe serum concentration of Istaroxime can be increased when it is combined with Itraconazole.Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Itraconazole.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Itraconazole.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Itraconazole.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Itraconazole.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Itraconazole.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Itraconazole.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Itraconazole.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Itraconazole.Approved
KetoconazoleThe metabolism of Itraconazole can be decreased when combined with Ketoconazole.Approved, Investigational
LacidipineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Lacidipine.Approved
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Itraconazole.Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Itraconazole.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Lamotrigine.Approved, Investigational
LansoprazoleThe serum concentration of Itraconazole can be decreased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Itraconazole.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Itraconazole.Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Itraconazole.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Itraconazole.Approved
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Itraconazole.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Itraconazole.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Itraconazole.Approved, Investigational
LeuprolideItraconazole may increase the QTc-prolonging activities of Leuprolide.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Itraconazole.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Itraconazole.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Itraconazole.Approved
LevofloxacinItraconazole may increase the QTc-prolonging activities of Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Itraconazole.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Itraconazole.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Itraconazole.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Itraconazole.Approved
LidocaineThe metabolism of Lidocaine can be decreased when combined with Itraconazole.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Itraconazole.Approved
LisurideThe metabolism of Lisuride can be decreased when combined with Itraconazole.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Itraconazole.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Itraconazole.Approved
LopinavirThe serum concentration of Itraconazole can be increased when it is combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Itraconazole.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Itraconazole.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Itraconazole.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Itraconazole.Approved, Investigational
LuliconazoleThe serum concentration of Itraconazole can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Itraconazole can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Itraconazole.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Itraconazole.Approved
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Itraconazole.Approved
MagaldrateThe serum concentration of Itraconazole can be decreased when it is combined with Magaldrate.Withdrawn
Magnesium carbonateThe serum concentration of Itraconazole can be decreased when it is combined with Magnesium carbonate.Approved
Magnesium hydroxideThe serum concentration of Itraconazole can be decreased when it is combined with Magnesium hydroxide.Approved
Magnesium oxideThe serum concentration of Itraconazole can be decreased when it is combined with Magnesium oxide.Approved
Magnesium SulfateThe risk or severity of adverse effects can be increased when Itraconazole is combined with Magnesium Sulfate.Approved, Vet Approved
Magnesium TrisilicateThe serum concentration of Itraconazole can be decreased when it is combined with Magnesium Trisilicate.Approved
ManidipineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Manidipine.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Itraconazole.Approved, Investigational
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Itraconazole.Approved, Investigational
ME-609The serum concentration of ME-609 can be increased when it is combined with Itraconazole.Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Itraconazole.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Itraconazole.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Itraconazole.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Itraconazole.Approved
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Itraconazole.Vet Approved
MeloxicamThe serum concentration of Meloxicam can be decreased when it is combined with Itraconazole.Approved, Vet Approved
MethadoneThe serum concentration of Methadone can be increased when it is combined with Itraconazole.Approved
MethanthelineThe serum concentration of Itraconazole can be decreased when it is combined with Methantheline.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Itraconazole.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Itraconazole.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Itraconazole.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Itraconazole.Approved, Vet Approved
MethylergometrineThe serum concentration of Methylergometrine can be increased when it is combined with Itraconazole.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Itraconazole.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Itraconazole.Approved
MetiamideThe serum concentration of Itraconazole can be decreased when it is combined with Metiamide.Experimental
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Itraconazole.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Itraconazole.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Itraconazole.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Itraconazole.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Itraconazole.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Itraconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Itraconazole.Approved, Illicit
MifepristoneMifepristone may increase the QTc-prolonging activities of Itraconazole.Approved, Investigational
MirabegronThe metabolism of Mirabegron can be decreased when combined with Itraconazole.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Itraconazole.Approved
MitotaneThe serum concentration of Itraconazole can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Itraconazole.Approved, Investigational
ModafinilThe metabolism of Modafinil can be decreased when combined with Itraconazole.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Itraconazole.Approved, Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Itraconazole.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Itraconazole.Approved, Investigational
MoxifloxacinItraconazole may increase the QTc-prolonging activities of Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Itraconazole.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Itraconazole.Approved
NafcillinThe serum concentration of Itraconazole can be decreased when it is combined with Nafcillin.Approved
NaftopidilThe risk or severity of adverse effects can be increased when Itraconazole is combined with Naftopidil.Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Itraconazole.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Itraconazole.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Itraconazole.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Itraconazole.Investigational
NefazodoneThe metabolism of Itraconazole can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Itraconazole can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Itraconazole can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Itraconazole can be decreased when it is combined with Nevirapine.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Itraconazole.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Itraconazole.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Itraconazole.Approved
NiguldipineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Niguldipine.Experimental
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Itraconazole.Approved, Investigational
NiludipineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Niludipine.Experimental
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Itraconazole.Approved
NimesulideThe risk or severity of adverse effects can be increased when Itraconazole is combined with Nimesulide.Approved, Withdrawn
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Itraconazole.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Itraconazole.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Itraconazole.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Itraconazole.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Itraconazole.Approved
NizatidineThe serum concentration of Itraconazole can be decreased when it is combined with Nizatidine.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Itraconazole.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Itraconazole.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Itraconazole.Approved
OfloxacinItraconazole may increase the QTc-prolonging activities of Ofloxacin.Approved
OlanzapineThe serum concentration of Itraconazole can be decreased when it is combined with Olanzapine.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Itraconazole.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be increased when it is combined with Itraconazole.Investigational
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Itraconazole.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Itraconazole.Approved
OmeprazoleThe serum concentration of Itraconazole can be decreased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Itraconazole.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Itraconazole.Approved
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Itraconazole.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Itraconazole.Approved
OuabainThe serum concentration of Ouabain can be increased when it is combined with Itraconazole.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Itraconazole.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Itraconazole.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Itraconazole is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Itraconazole.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Itraconazole.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Itraconazole.Approved
PaliperidoneItraconazole may increase the QTc-prolonging activities of Paliperidone.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Itraconazole.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Itraconazole.Approved, Investigational
PantoprazoleThe serum concentration of Itraconazole can be decreased when it is combined with Pantoprazole.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Itraconazole.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Itraconazole.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Itraconazole.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Itraconazole.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Itraconazole.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Itraconazole.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Itraconazole.Approved
PentobarbitalThe serum concentration of Itraconazole can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Itraconazole.Approved
PerflutrenItraconazole may increase the QTc-prolonging activities of Perflutren.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Itraconazole.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Itraconazole.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Itraconazole.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Itraconazole.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Itraconazole.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Itraconazole.Withdrawn
PhenindioneThe serum concentration of Phenindione can be increased when it is combined with Itraconazole.Approved
PhenobarbitalThe serum concentration of Itraconazole can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Itraconazole.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Itraconazole.Approved
PhenytoinThe serum concentration of Itraconazole can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Itraconazole.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Itraconazole.Approved, Investigational
PimozideItraconazole may increase the arrhythmogenic activities of Pimozide.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Itraconazole.Withdrawn
PinaveriumThe risk or severity of adverse effects can be increased when Itraconazole is combined with Pinaverium.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Itraconazole.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Itraconazole.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Itraconazole.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Itraconazole.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Itraconazole.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Itraconazole.Approved
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Itraconazole.Approved, Investigational, Vet Approved
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Itraconazole.Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Itraconazole.Approved, Nutraceutical
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Itraconazole resulting in a loss in efficacy.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Itraconazole.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Itraconazole.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Itraconazole.Approved, Vet Approved
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Itraconazole.Approved
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Itraconazole.Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Itraconazole.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Itraconazole.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Itraconazole.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Itraconazole is combined with Pregabalin.Approved, Illicit, Investigational
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Itraconazole.Experimental
PrenylamineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Prenylamine.Withdrawn
PrimaquineThe metabolism of Primaquine can be decreased when combined with Itraconazole.Approved
PrimidoneThe serum concentration of Itraconazole can be decreased when it is combined with Primidone.Approved, Vet Approved
ProcainamideItraconazole may increase the QTc-prolonging activities of Procainamide.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Itraconazole.Approved, Vet Approved
ProgesteroneThe therapeutic efficacy of Progesterone can be decreased when used in combination with Itraconazole.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Itraconazole.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Itraconazole.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Itraconazole.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Itraconazole.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Itraconazole.Approved, Investigational
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Itraconazole.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Itraconazole.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Itraconazole.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Itraconazole.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Itraconazole.Approved
QuinidineThe metabolism of Quinidine can be decreased when combined with Itraconazole.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Itraconazole.Approved
RabeprazoleThe serum concentration of Itraconazole can be decreased when it is combined with Rabeprazole.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Itraconazole.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Itraconazole.Approved, Investigational
RanitidineThe serum concentration of Itraconazole can be decreased when it is combined with Ranitidine.Approved
RanolazineThe metabolism of Ranolazine can be decreased when combined with Itraconazole.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Itraconazole.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Itraconazole.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Itraconazole.Approved, Investigational
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Itraconazole.Approved
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Itraconazole.Approved
RifabutinThe serum concentration of Itraconazole can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Itraconazole can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Itraconazole can be decreased when it is combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Itraconazole.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Itraconazole.Approved
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Itraconazole.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Itraconazole.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Itraconazole.Approved
RisedronateThe risk or severity of adverse effects can be increased when Itraconazole is combined with Risedronate.Approved, Investigational
RisperidoneThe metabolism of Risperidone can be decreased when combined with Itraconazole.Approved, Investigational
RitonavirThe serum concentration of Itraconazole can be increased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Itraconazole.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Itraconazole.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Itraconazole.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Itraconazole.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Itraconazole.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Itraconazole.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Itraconazole.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Itraconazole.Approved
Roxatidine acetateThe serum concentration of Itraconazole can be decreased when it is combined with Roxatidine acetate.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Itraconazole.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Itraconazole.Approved
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Itraconazole.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Itraconazole.Approved
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Itraconazole.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Itraconazole.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Itraconazole.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Itraconazole.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Itraconazole.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Itraconazole.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Itraconazole.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Itraconazole.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Itraconazole.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Itraconazole.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Itraconazole.Approved
SiltuximabThe serum concentration of Itraconazole can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Itraconazole.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Itraconazole.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Itraconazole.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Itraconazole.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Itraconazole.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Itraconazole.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Itraconazole.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Itraconazole.Approved, Investigational
SotalolItraconazole may increase the QTc-prolonging activities of Sotalol.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Itraconazole.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Itraconazole.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Itraconazole.Approved
St. John's WortThe serum concentration of Itraconazole can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Itraconazole can be increased when it is combined with Stiripentol.Approved
SucralfateSucralfate can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Itraconazole.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Itraconazole.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Itraconazole.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Itraconazole.Approved
SulfisoxazoleItraconazole may increase the QTc-prolonging activities of Sulfisoxazole.Approved, Vet Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Itraconazole.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Itraconazole.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Itraconazole.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Itraconazole.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Itraconazole.Approved, Investigational
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Itraconazole.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Itraconazole.Approved, Investigational
TAK-390MRThe serum concentration of Itraconazole can be decreased when it is combined with TAK-390MR.Investigational
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Itraconazole.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Itraconazole.Approved, Investigational
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Itraconazole.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Itraconazole.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Itraconazole.Experimental
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Itraconazole.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Itraconazole.Approved
TelaprevirThe serum concentration of Itraconazole can be increased when it is combined with Telaprevir.Approved
TelavancinItraconazole may increase the QTc-prolonging activities of Telavancin.Approved
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Itraconazole.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Itraconazole.Approved
TemsirolimusThe serum concentration of the active metabolites of Temsirolimus can be increased when Temsirolimus is used in combination with Itraconazole.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Itraconazole.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Itraconazole.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Itraconazole.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Itraconazole.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Itraconazole.Approved, Investigational
TetrabenazineItraconazole may increase the QTc-prolonging activities of Tetrabenazine.Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Itraconazole.Approved, Vet Approved
TheophyllineThe metabolism of Theophylline can be decreased when combined with Itraconazole.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Itraconazole.Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Itraconazole.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Itraconazole.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Itraconazole resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Itraconazole.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Itraconazole.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Itraconazole.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Itraconazole.Approved
TipranavirThe serum concentration of Itraconazole can be increased when it is combined with Tipranavir.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Itraconazole.Approved
TocilizumabThe serum concentration of Itraconazole can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Itraconazole.Approved, Investigational
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Itraconazole is combined with Tolfenamic Acid.Approved
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Itraconazole.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Itraconazole.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Itraconazole.Approved, Investigational
ToremifeneThe risk or severity of adverse effects can be increased when Itraconazole is combined with Toremifene.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Itraconazole.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Itraconazole.Approved, Investigational
TranilastThe risk or severity of adverse effects can be increased when Itraconazole is combined with Tranilast.Approved, Investigational
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Itraconazole.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Itraconazole.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Itraconazole.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Itraconazole.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Itraconazole.Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Itraconazole.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Itraconazole.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Itraconazole.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Itraconazole.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Itraconazole.Approved
UdenafilThe metabolism of Udenafil can be decreased when combined with Itraconazole.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Itraconazole.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Itraconazole.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Itraconazole.Investigational, Withdrawn
VandetanibThe metabolism of Vandetanib can be decreased when combined with Itraconazole.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Itraconazole.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Itraconazole.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Itraconazole.Approved
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Itraconazole.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Itraconazole.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Itraconazole.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Itraconazole.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Itraconazole.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Itraconazole.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Itraconazole.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Itraconazole.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Itraconazole.Approved, Investigational
VincristineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Vincristine.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Itraconazole.Approved
VinorelbineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Vinorelbine.Approved, Investigational
VinpocetineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Vinpocetine.Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Itraconazole.Approved
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Itraconazole.Approved
VoriconazoleThe metabolism of Itraconazole can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Itraconazole.Approved
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Itraconazole.Approved
XylometazolineThe risk or severity of adverse effects can be increased when Itraconazole is combined with Xylometazoline.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Itraconazole.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Itraconazole.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Itraconazole.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Itraconazole.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Itraconazole is combined with Ziconotide.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Itraconazole.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Itraconazole.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Itraconazole.Approved
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Itraconazole.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Itraconazole.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Itraconazole.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Itraconazole.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Itraconazole.Approved, Investigational
Food Interactions
  • Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
  • Avoid taking with grapefruit juice.
  • Take after a full meal.
  • Take with food.
References
Synthesis Reference

Jong-Soo Woo, Hong-Gi Yi, “Antifungal oral composition containing itraconazole and process for preparing same.” U.S. Patent US6039981, issued May, 1998.

US6039981
General ReferencesNot Available
External Links
ATC CodesJ02AC02
AHFS Codes
  • 08:14.08
PDB Entries
FDA labelDownload (1.58 MB)
MSDSDownload (73.6 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9973
Blood Brain Barrier-0.6151
Caco-2 permeable+0.5511
P-glycoprotein substrateSubstrate0.6397
P-glycoprotein inhibitor IInhibitor0.7973
P-glycoprotein inhibitor IINon-inhibitor0.88
Renal organic cation transporterNon-inhibitor0.7497
CYP450 2C9 substrateNon-substrate0.8116
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7408
CYP450 1A2 substrateNon-inhibitor0.7666
CYP450 2C9 inhibitorInhibitor0.618
CYP450 2D6 inhibitorNon-inhibitor0.8622
CYP450 2C19 inhibitorInhibitor0.5703
CYP450 3A4 inhibitorInhibitor0.5279
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8219
Ames testAMES toxic0.5303
CarcinogenicityNon-carcinogens0.7478
BiodegradationNot ready biodegradable1.0
Rat acute toxicity3.3118 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.5782
hERG inhibition (predictor II)Inhibitor0.6096
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
CapsuleOral100 mg/1
TabletOral200 mg/1
CapsuleOral100 mg
SolutionOral10 mg/mL
SolutionOral10 mg
Prices
Unit descriptionCostUnit
Itraconazole 28 100 mg capsule Disp Pack270.89USD disp
Itraconazole powder32.13USD g
Sporanox 100 mg capsule12.14USD capsule
Itraconazole 100 mg capsule9.46USD capsule
Sporanox 10 mg/ml Solution1.41USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA1336498 No1995-08-012012-08-01Canada
CA2142848 No1999-11-162013-08-27Canada
US5633015 No1994-05-272014-05-27Us
US6407079 No1999-06-182019-06-18Us
US6509038 No1997-05-122017-05-12Us
US7081255 No1997-05-122017-05-12Us
US8486456 No2008-10-032028-10-03Us
US8591948 No1997-05-122017-05-12Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point166.2 °CNot Available
water solubilityInsolubleNot Available
logP5.66HTTP://WWW.RXLIST.COM
pKa3.70Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00964 mg/mLALOGPS
logP5.48ALOGPS
logP7.31ChemAxon
logS-4.9ALOGPS
pKa (Strongest Basic)3.92ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area100.79 Å2ChemAxon
Rotatable Bond Count11ChemAxon
Refractivity200.4 m3·mol-1ChemAxon
Polarizability74.7 Å3ChemAxon
Number of Rings7ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassDiazinanes
Sub ClassPiperazines
Direct ParentPhenylpiperazines
Alternative Parents
Substituents
  • N-arylpiperazine
  • Phenylpiperazine
  • Phenyl-1,3,4-triazole
  • Phenyl-1,2,4-triazole
  • Phenyltriazole
  • Substituted aniline
  • Dialkylarylamine
  • Phenol ether
  • 1,3-dichlorobenzene
  • Glycerol ether
  • Halobenzene
  • Chlorobenzene
  • Aniline
  • Alkyl aryl ether
  • Benzenoid
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • 1,2,4-triazole
  • Triazole
  • Azole
  • Meta-dioxolane
  • Tertiary amine
  • Oxacycle
  • Azacycle
  • Ether
  • Acetal
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Yeast
Pharmacological action
yes
Actions
inhibitor
General Function:
Sterol 14-demethylase activity
Specific Function:
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity).
Gene Name:
ERG11
Uniprot ID:
P50859
Molecular Weight:
61304.95 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Gachotte D, Pierson CA, Lees ND, Barbuch R, Koegel C, Bard M: A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11173-8. [PubMed:9326581 ]
  4. Henry KW, Nickels JT, Edlind TD: Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors. Antimicrob Agents Chemother. 2000 Oct;44(10):2693-700. [PubMed:10991846 ]
  5. Morales IJ, Vohra PK, Puri V, Kottom TJ, Limper AH, Thomas CF Jr: Characterization of a lanosterol 14 alpha-demethylase from Pneumocystis carinii. Am J Respir Cell Mol Biol. 2003 Aug;29(2):232-8. Epub 2003 Feb 26. [PubMed:12606318 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Sterol 14-demethylase activity
Specific Function:
Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name:
CYP51A1
Uniprot ID:
Q16850
Molecular Weight:
56805.26 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Cotrim PC, Garrity LK, Beverley SM: Isolation of genes mediating resistance to inhibitors of nucleoside and ergosterol metabolism in Leishmania by overexpression/selection. J Biol Chem. 1999 Dec 31;274(53):37723-30. [PubMed:10608831 ]
  3. Carrillo-Munoz AJ, Giusiano G, Ezkurra PA, Quindos G: Antifungal agents: mode of action in yeast cells. Rev Esp Quimioter. 2006 Jun;19(2):130-9. [PubMed:16964330 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Niwa T, Shiraga T, Takagi A: Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes. Biol Pharm Bull. 2005 Sep;28(9):1805-8. [PubMed:16141567 ]
  2. Sakaeda T, Iwaki K, Kakumoto M, Nishikawa M, Niwa T, Jin JS, Nakamura T, Nishiguchi K, Okamura N, Okumura K: Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs. J Pharm Pharmacol. 2005 Jun;57(6):759-64. [PubMed:15969931 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  4. Dresser GK, Spence JD, Bailey DG: Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. Clin Pharmacokinet. 2000 Jan;38(1):41-57. [PubMed:10668858 ]
  5. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. [PubMed:17101742 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514 ]
  2. Wang EJ, Lew K, Casciano CN, Clement RP, Johnson WW: Interaction of common azole antifungals with P glycoprotein. Antimicrob Agents Chemother. 2002 Jan;46(1):160-5. [PubMed:11751127 ]
  3. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
  4. Takara K, Tanigawara Y, Komada F, Nishiguchi K, Sakaeda T, Okumura K: Cellular pharmacokinetic aspects of reversal effect of itraconazole on P-glycoprotein-mediated resistance of anticancer drugs. Biol Pharm Bull. 1999 Dec;22(12):1355-9. [PubMed:10746169 ]
  5. Masuda S, Inui K: [Molecular mechanisms on drug transporters in the drug absorption and disposition]. Nihon Rinsho. 2002 Jan;60(1):65-73. [PubMed:11808341 ]
  6. Lilja JJ, Backman JT, Laitila J, Luurila H, Neuvonen PJ: Itraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprolol. Clin Pharmacol Ther. 2003 Mar;73(3):192-8. [PubMed:12621384 ]
  7. Sakaeda T, Iwaki K, Kakumoto M, Nishikawa M, Niwa T, Jin JS, Nakamura T, Nishiguchi K, Okamura N, Okumura K: Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs. J Pharm Pharmacol. 2005 Jun;57(6):759-64. [PubMed:15969931 ]
  8. Saito M, Hirata-Koizumi M, Miyake S, Hasegawa R: Comparison of information on the pharmacokinetic interactions of Ca antagonists in the package inserts from three countries (Japan, USA and UK). Eur J Clin Pharmacol. 2005 Aug;61(7):531-6. Epub 2005 Jul 23. [PubMed:16041596 ]
  9. Shon JH, Yoon YR, Hong WS, Nguyen PM, Lee SS, Choi YG, Cha IJ, Shin JG: Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphism. Clin Pharmacol Ther. 2005 Aug;78(2):191-201. [PubMed:16084853 ]
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Drug created on June 13, 2005 07:24 / Updated on December 02, 2016 02:43