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Identification
NameKetoconazole
Accession NumberDB01026  (APRD00401)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionBroad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients. [PubChem]
Structure
Thumb
Synonyms
Extina
Ketoconazol
Ketoconazole
Ketoconazolum
Ketozole
Nizoral
Nizoral a-D
Xolegel
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ExtinaAerosol, foam20 mg/gTopicalPrestium Pharma, Inc.2014-01-10Not applicableUs
KetoconazoleShampoo20 mg/mLTopicalPatriot Pharmaceuticals, LLC2005-07-01Not applicableUs
Ketoderm Cream 2%Cream2 %TopicalTaropharma, A Division Of Taro Pharmaceuticals Inc.2002-05-23Not applicableCanada
NizoralShampoo20 mg/mLTopicalJanssen Pharmaceuticals, Inc.1990-08-31Not applicableUs
NizoralShampoo20 mg/mLTopicalA S Medication Solutions Llc1990-08-31Not applicableUs
NizoralTablet200 mg/1OralJanssen Pharmaceuticals, Inc.1981-06-12Not applicableUs
Nizoral Cream 2%Cream2 %TopicalMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1988-12-312007-08-02Canada
Nizoral Oral Suspension 20mg/mlSuspension20 mgOralJanssen Pharmaceutica, Division Of Janssen Ortho Inc.1989-12-311998-02-06Canada
Nizoral Shp 2%Shampoo2 %TopicalJanssen Pharmaceutica, Division Of Janssen Ortho Inc.1990-12-311997-08-12Canada
Nizoral Tablets 200mgTablet200 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1984-12-312003-02-06Canada
Nu-ketocon Tablets - 200mgTablet200 mgOralNu Pharm Inc1998-09-012012-09-04Canada
Teva-ketoconazoleTablet200 mgOralTeva Canada Limited1999-06-30Not applicableCanada
XolegelGel20 mg/gTopicalAqua Pharmaceuticals2006-07-28Not applicableUs
XolegelGel2 %TopicalBarrier Therapeutics Canada Inc.Not applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-ketoconazoleTablet200 mgOralApotex Inc1998-02-03Not applicableCanada
KetoconazoleCream20 mg/gTopicalRebel Distributors Corp2002-12-18Not applicableUs
KetoconazoleCream20 mg/gTopicalPreferred Pharmaceuticals, Inc.2014-02-28Not applicableUs
KetoconazoleCream20 mg/gTopicalREMEDYREPACK INC.2013-06-12Not applicableUs
KetoconazoleTablet200 mg/1OralA S Medication Solutions2000-02-23Not applicableUs
KetoconazoleCream20 mg/gTopicalTeva Pharmaceuticals USA Inc2000-04-27Not applicableUs
KetoconazoleShampoo, suspension20 mg/mLTopicalPhysicians Total Care, Inc.2006-07-24Not applicableUs
KetoconazoleShampoo, suspension20 mg/mLTopicalPerrigo New York Inc2010-01-19Not applicableUs
KetoconazoleTablet200 mg/1OralCarilion Materials Management1999-06-15Not applicableUs
KetoconazoleTablet200 mg/1OralAidarex Pharmaceuticals LLC1999-06-15Not applicableUs
KetoconazoleShampoo, suspension20 mg/mLTopicalAidarex Pharmaceuticals LLC2010-01-19Not applicableUs
KetoconazoleCream20 mg/gTopicalUnit Dose Services2002-12-18Not applicableUs
KetoconazoleTablet200 mg/1OralMylan Pharmaceuticals Inc.2000-02-23Not applicableUs
KetoconazoleCream20 mg/gTopicalDispensing Solutions, Inc.2002-12-18Not applicableUs
KetoconazoleCream20 mg/gTopicalTaro Pharmaceuticals U.S.A., Inc.2002-12-18Not applicableUs
KetoconazoleShampoo, suspension20 mg/mLTopicalA S Medication Solutions2010-01-19Not applicableUs
KetoconazoleCream20 mg/gTopicalRebel Distributors Corp2002-12-18Not applicableUs
KetoconazoleTablet200 mg/1OralPreferred Pharmaceuticals, Inc.2013-02-05Not applicableUs
KetoconazoleCream20 mg/1TopicalREMEDYREPACK INC.2013-04-15Not applicableUs
KetoconazoleTablet200 mg/1OralA S Medication Solutions2000-02-23Not applicableUs
KetoconazoleTablet200 mg/1OralTeva Pharmaceuticals USA Inc1999-06-15Not applicableUs
KetoconazoleTablet200 mg/1OralGolden State Medical Supply, Inc.2009-05-20Not applicableUs
KetoconazoleAerosol, foam2 g/100gTopicalPerrigo New York Inc2011-08-30Not applicableUs
KetoconazoleCream20 mg/gTopicalA S Medication Solutions2004-04-28Not applicableUs
KetoconazoleTablet200 mg/1OralPd Rx Pharmaceuticals, Inc.2011-05-20Not applicableUs
KetoconazoleTablet200 mg/1OralAvera Mc Kennan Hospital2015-11-05Not applicableUs
KetoconazoleTablet200 mg/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
KetoconazoleTablet200 mg/1OralA S Medication Solutions2000-02-23Not applicableUs
KetoconazoleCream20 mg/gTopicalG&W Laboratories, Inc.2015-06-15Not applicableUs
KetoconazoleTablet200 mg/1OralPreferred Pharmaceuticals, Inc.2011-05-31Not applicableUs
KetoconazoleTablet200 mg/1OralTaro Pharmaceuticals U.S.A., Inc.1999-06-15Not applicableUs
KetoconazoleCream20 mg/gTopicalA S Medication Solutions2002-12-18Not applicableUs
KetoconazoleCream20 mg/gTopicalRebel Distributors Corp2002-12-18Not applicableUs
KetoconazoleShampoo, suspension20 mg/mLTopicalPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
KetoconazoleCream20 mg/gTopicalREMEDYREPACK INC.2013-05-06Not applicableUs
KetoconazoleShampoo, suspension20.5 mg/mLTopicalTOLMAR Inc.2016-10-01Not applicableUs
KetoconazoleCream20 mg/gTopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.2004-04-28Not applicableUs
KetoconazoleTablet200 mg/1Oralbryant ranch prepack1999-06-15Not applicableUs
KetoconazoleTablet200 mg/1OralREMEDYREPACK INC.2011-07-142016-10-13Us
KetoconazoleCream20 mg/gTopicalA S Medication Solutions2004-04-28Not applicableUs
KetoconazoleCream20 mg/gTopicalUnit Dose Services2004-04-28Not applicableUs
KetoconazoleCream20 mg/gTopicalPhysicians Total Care, Inc.2001-08-01Not applicableUs
KetoconazoleCream20 mg/gTopicalDIRECT RX2014-01-01Not applicableUs
KetoconazoleTablet200 mg/1OralREMEDYREPACK INC.2013-03-152016-10-13Us
KetoconazoleCream20 mg/gTopicalA S Medication Solutions2002-12-18Not applicableUs
KetoconazoleTablet200 mg/1OralSTAT Rx USA LLC2011-05-31Not applicableUs
KetoconazoleShampoo, suspension20.5 mg/mLTopicalPreferred Pharmaceuticals, Inc.2014-06-16Not applicableUs
KetoconazoleTablet200 mg/1OralRebel Distributors Corp1999-06-15Not applicableUs
KetoconazoleCream20 mg/gTopicalPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
KetoconazoleCream20 mg/gTopicalREMEDYREPACK INC.2013-06-04Not applicableUs
KetoconazoleCream20 mg/gTopicalUnit Dose Services2004-04-28Not applicableUs
KetoconazoleTablet200 mg/1OralKAISER FOUNDATION HOSPITALS2010-03-02Not applicableUs
KetoconazoleTablet200 mg/1OralAmerican Health Packaging2012-01-20Not applicableUs
KetoconazoleTablet200 mg/1OralLake Erie Medical DBA Quality Care Products LLC1999-06-15Not applicableUs
KetoconazoleTablet200 mg/1OralA S Medication Solutions1999-06-15Not applicableUs
KetoconazoleShampoo, suspension20.5 mg/mLTopicalSandoz Inc.2005-11-04Not applicableUs
KetoconazoleTablet200 mg/1OralPhysicians Total Care, Inc.2004-05-24Not applicableUs
KetoconazoleCream20 mg/gTopicalProficient Rx LP2002-12-18Not applicableUs
KetodanAerosol, foam20 mg/gTopicalMedimetriks Pharmaceuticals, Inc.2012-06-15Not applicableUs
KetodanKitMedimetriks Pharmaceuticals, Inc.2012-06-15Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nizoral - 2%Shampoo2 %TopicalJohnson & Johnson Inc1990-12-30Not applicableCanada
Nizoral A-DShampoo10 mg/mLTopicalJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division1999-04-01Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
FungarestJanssen-Cilag
FungoralJohnson & Johnson
KetodermHessel
KetoisdinIsdin
KetozoleRanbaxy
Nizoral CreamOrtho-McNeil
Nizoral ShampooOrtho-McNeil
OrifungalJanssen
Orifungal MJanssen
PanfungolEsteve
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIR9400W927I
CAS number65277-42-1
WeightAverage: 531.431
Monoisotopic: 530.148760818
Chemical FormulaC26H28Cl2N4O4
InChI KeyXMAYWYJOQHXEEK-UHFFFAOYSA-N
InChI
InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3
IUPAC Name
1-[4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one
SMILES
CC(=O)N1CCN(CC1)C1=CC=C(OCC2COC(CN3C=CN=C3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1
Pharmacology
IndicationFor the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
Structured Indications
PharmacodynamicsKetoconazole, like clotrimazole, fluconazole, itraconazole, and miconazole, is an imidazole antifungal agent.
Mechanism of actionKetoconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol synthesis and increased fungal cellular permeability. Other mechanisms may involve the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone.
TargetKindPharmacological actionActionsOrganismUniProt ID
Lanosterol 14-alpha demethylaseProteinyes
inhibitor
YeastP10613 details
Androgen receptorProteinunknown
binder
HumanP10275 details
17-hydroxylase ProteinunknownNot AvailableHumannot applicabledetails
Steroid 21-hydroxylaseProteinunknownNot AvailableHumanP08686 details
11-hydroxylaseProteinunknownNot AvailableHumannot applicabledetails
AromataseProteinunknownNot AvailableHumanP11511 details
Related Articles
AbsorptionModerate
Volume of distributionNot Available
Protein binding99% (in vitro, plasma protein binding)
Metabolism

Hepatic

Route of eliminationNot Available
Half life2 hours
ClearanceNot Available
ToxicityHepatotoxicity, LD50=86 mg/kg (orally in rat)
Affected organisms
  • Fungi
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Ketoconazole.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Ketoconazole.Experimental, Illicit
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Ketoconazole.Experimental, Illicit
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Ketoconazole.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Ketoconazole.Experimental, Illicit
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Ketoconazole.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Ketoconazole.Approved
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Ketoconazole.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Ketoconazole.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Ketoconazole.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Ketoconazole.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Ketoconazole.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Ketoconazole.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Ketoconazole.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Ketoconazole.Approved
AjmalineThe metabolism of Ajmaline can be decreased when combined with Ketoconazole.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Ketoconazole.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Ketoconazole.Approved
AldosteroneThe serum concentration of Ketoconazole can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Ketoconazole can be increased when it is combined with Alectinib.Approved
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Ketoconazole.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Ketoconazole.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Ketoconazole.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Ketoconazole.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Ketoconazole.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Ketoconazole.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Ketoconazole.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Ketoconazole.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Ketoconazole.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Ketoconazole.Approved, Illicit, Investigational
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Ketoconazole.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Ketoconazole.Approved, Withdrawn
Aluminum hydroxideThe serum concentration of Ketoconazole can be decreased when it is combined with Aluminum hydroxide.Approved
Aluminum phosphateThe serum concentration of Ketoconazole can be decreased when it is combined with Aluminum phosphate.Approved
AmantadineThe serum concentration of Ketoconazole can be increased when it is combined with Amantadine.Approved
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Ketoconazole.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Ketoconazole.Approved
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Ketoconazole.Approved
Aminohippuric acidThe serum concentration of Ketoconazole can be increased when it is combined with Aminohippuric acid.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Ketoconazole.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Ketoconazole.Approved
AmiodaroneThe metabolism of Ketoconazole can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Ketoconazole.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Ketoconazole.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Ketoconazole.Approved
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Ketoconazole.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Ketoconazole.Approved, Vet Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Ketoconazole.Approved, Illicit
Amphotericin BThe therapeutic efficacy of Amphotericin B can be decreased when used in combination with Ketoconazole.Approved, Investigational
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Ketoconazole.Approved
AmrinoneThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Amrinone.Approved
AmsacrineThe serum concentration of Ketoconazole can be increased when it is combined with Amsacrine.Approved
AnagrelideKetoconazole may increase the QTc-prolonging activities of Anagrelide.Approved
AnecortaveThe serum concentration of Anecortave can be increased when it is combined with Ketoconazole.Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Ketoconazole.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Ketoconazole.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Ketoconazole.Approved, Investigational
AprepitantThe serum concentration of Ketoconazole can be increased when it is combined with Aprepitant.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Ketoconazole.Approved
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Ketoconazole.Experimental
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Ketoconazole.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Ketoconazole.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Ketoconazole.Approved, Investigational
Arsenic trioxideKetoconazole may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Ketoconazole.Approved
ArtesunateThe serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Ketoconazole resulting in a loss in efficacy.Approved
AsenapineThe serum concentration of Ketoconazole can be decreased when it is combined with Asenapine.Approved
AsenapineThe metabolism of Asenapine can be decreased when combined with Ketoconazole.Approved
AstemizoleKetoconazole may increase the QTc-prolonging activities of Astemizole.Approved, Withdrawn
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Ketoconazole.Approved, Withdrawn
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Ketoconazole.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Ketoconazole.Approved
AtomoxetineThe metabolism of Ketoconazole can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe risk or severity of adverse effects can be increased when Atorvastatin is combined with Ketoconazole.Approved
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Ketoconazole.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Ketoconazole.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Ketoconazole.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Ketoconazole.Approved
AzelnidipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Azelnidipine.Approved
AzimilideThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Azimilide.Investigational
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Ketoconazole.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Ketoconazole.Investigational
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Ketoconazole.Approved
BeclomethasoneThe serum concentration of Beclomethasone can be increased when it is combined with Ketoconazole.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Ketoconazole.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Ketoconazole.Approved
BenidipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Benidipine.Approved
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Ketoconazole.Approved
BenzocaineThe serum concentration of Ketoconazole can be increased when it is combined with Benzocaine.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Ketoconazole.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Ketoconazole.Approved
BepridilThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Ketoconazole.Approved, Vet Approved
BetaxololThe metabolism of Betaxolol can be decreased when combined with Ketoconazole.Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Ketoconazole.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Ketoconazole.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Ketoconazole.Approved
BiperidenThe serum concentration of Ketoconazole can be increased when it is combined with Biperiden.Approved
Bismuth SubcitrateThe serum concentration of Ketoconazole can be decreased when it is combined with Bismuth Subcitrate.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Ketoconazole.Approved
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Ketoconazole.Approved
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Ketoconazole.Approved
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Ketoconazole.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Ketoconazole.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Ketoconazole.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Ketoconazole.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Ketoconazole.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Ketoconazole.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Ketoconazole.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Ketoconazole.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Ketoconazole.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Ketoconazole.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Ketoconazole.Approved
BufuralolThe metabolism of Bufuralol can be decreased when combined with Ketoconazole.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Ketoconazole.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Ketoconazole.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Ketoconazole.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Ketoconazole.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Ketoconazole.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Ketoconazole.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Ketoconazole.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Ketoconazole.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Ketoconazole.Approved
CaiThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Cai.Investigational
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Ketoconazole.Approved, Nutraceutical
Calcium carbonateThe serum concentration of Ketoconazole can be decreased when it is combined with Calcium carbonate.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Ketoconazole.Experimental
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Ketoconazole.Approved
CandesartanThe serum concentration of Ketoconazole can be increased when it is combined with Candesartan.Approved
CaptoprilThe serum concentration of Ketoconazole can be increased when it is combined with Captopril.Approved
CarbamazepineThe metabolism of Ketoconazole can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Ketoconazole.Approved
CarbocisteineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Carbocisteine.Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Ketoconazole.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Ketoconazole.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Ketoconazole.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Ketoconazole.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Ketoconazole.Approved, Investigational
CaspofunginThe serum concentration of Ketoconazole can be increased when it is combined with Caspofungin.Approved
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Ketoconazole.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Ketoconazole.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Ketoconazole.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Ketoconazole.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Ketoconazole.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Ketoconazole.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Ketoconazole.Approved
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Ketoconazole.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Ketoconazole.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Ketoconazole.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Ketoconazole.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Ketoconazole.Approved, Vet Approved
ChlorpropamideThe serum concentration of Ketoconazole can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Ketoconazole can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Ketoconazole.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Ketoconazole.Approved, Nutraceutical
CholesterolThe serum concentration of Ketoconazole can be increased when it is combined with Cholesterol.Experimental
Cholic AcidKetoconazole may decrease the excretion rate of Cholic Acid which could result in a higher serum level.Approved
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Ketoconazole.Approved, Investigational
CilazaprilThe serum concentration of Ketoconazole can be increased when it is combined with Cilazapril.Approved
CilnidipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Cilnidipine.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Ketoconazole.Approved
CimetidineThe serum concentration of Ketoconazole can be decreased when it is combined with Cimetidine.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Ketoconazole.Approved
CinnarizineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Cinnarizine.Approved
CiprofloxacinKetoconazole may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Ketoconazole.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Ketoconazole.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Ketoconazole.Approved
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Ketoconazole.Approved
ClemastineThe metabolism of Ketoconazole can be decreased when combined with Clemastine.Approved
ClevidipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Clevidipine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Ketoconazole.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Ketoconazole.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be increased when it is combined with Ketoconazole.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Ketoconazole.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Ketoconazole.Approved
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Ketoconazole.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Ketoconazole.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Ketoconazole.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Ketoconazole.Approved, Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Ketoconazole.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Ketoconazole.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Ketoconazole.Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Ketoconazole resulting in a loss in efficacy.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Ketoconazole.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Ketoconazole.Approved, Illicit
ClotrimazoleThe metabolism of Ketoconazole can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Ketoconazole.Approved
CobicistatThe serum concentration of Cobicistat can be increased when it is combined with Ketoconazole.Approved
CobicistatThe metabolism of Ketoconazole can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Ketoconazole.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Ketoconazole.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Ketoconazole.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Ketoconazole.Approved
ColforsinThe serum concentration of Ketoconazole can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Ketoconazole.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Ketoconazole.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Ketoconazole.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Ketoconazole.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Ketoconazole.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Ketoconazole.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Ketoconazole.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Ketoconazole.Approved, Investigational
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Ketoconazole.Approved
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Ketoconazole.Approved
DabrafenibThe serum concentration of Ketoconazole can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Ketoconazole.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Ketoconazole.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Ketoconazole.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Ketoconazole.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Ketoconazole.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Ketoconazole.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Ketoconazole.Approved, Investigational
DarodipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Darodipine.Experimental
DarunavirThe serum concentration of Ketoconazole can be increased when it is combined with Darunavir.Approved
DarunavirThe metabolism of Darunavir can be decreased when combined with Ketoconazole.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Ketoconazole.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Ketoconazole.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Ketoconazole.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Ketoconazole.Approved
DeferasiroxThe serum concentration of Ketoconazole can be decreased when it is combined with Deferasirox.Approved, Investigational
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Ketoconazole.Investigational
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Ketoconazole.Approved
DesipramineThe serum concentration of Ketoconazole can be increased when it is combined with Desipramine.Approved
DesloratadineThe serum concentration of Ketoconazole can be increased when it is combined with Desloratadine.Approved, Investigational
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Ketoconazole.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Ketoconazole.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Ketoconazole.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Ketoconazole.Approved
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Ketoconazole.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Ketoconazole.Vet Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Ketoconazole.Approved, Illicit, Withdrawn
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Ketoconazole.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Ketoconazole.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Ketoconazole.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Ketoconazole.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Ketoconazole.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Ketoconazole.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Ketoconazole.Approved
DicoumarolThe serum concentration of Dicoumarol can be increased when it is combined with Ketoconazole.Approved
DidanosineDidanosine can cause a decrease in the absorption of Ketoconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DienogestThe serum concentration of Dienogest can be increased when it is combined with Ketoconazole.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Ketoconazole.Approved
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Ketoconazole.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Ketoconazole.Approved
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Ketoconazole.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Ketoconazole.Approved
DigoxinThe metabolism of Digoxin can be decreased when combined with Ketoconazole.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Ketoconazole.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Ketoconazole.Approved
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Ketoconazole.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ketoconazole.Illicit
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Ketoconazole.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Ketoconazole.Approved
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Ketoconazole.Approved
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Ketoconazole.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Ketoconazole.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Ketoconazole.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Ketoconazole.Approved, Investigational
DofetilideThe metabolism of Dofetilide can be decreased when combined with Ketoconazole.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Ketoconazole.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Ketoconazole.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Ketoconazole.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Ketoconazole.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Ketoconazole.Approved
DotarizineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Dotarizine.Investigational
DoxazosinThe serum concentration of Ketoconazole can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Ketoconazole can be decreased when it is combined with Doxepin.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Ketoconazole.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Ketoconazole.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Ketoconazole.Approved, Investigational
DoxycyclineThe metabolism of Ketoconazole can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Ketoconazole.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Ketoconazole.Approved
DroperidolKetoconazole may increase the QTc-prolonging activities of Droperidol.Approved, Vet Approved
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Ketoconazole.Approved
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Ketoconazole.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Ketoconazole.Approved, Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Ketoconazole.Approved
EfavirenzThe serum concentration of Ketoconazole can be decreased when it is combined with Efavirenz.Approved, Investigational
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Ketoconazole.Approved, Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Efonidipine.Approved
ElbasvirThe serum concentration of Ketoconazole can be increased when it is combined with Elbasvir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Ketoconazole.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Ketoconazole.Approved
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Ketoconazole.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Ketoconazole.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Ketoconazole.Approved, Vet Approved
EncainideThe metabolism of Encainide can be decreased when combined with Ketoconazole.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Ketoconazole.Investigational
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Ketoconazole.Approved, Investigational
EnzalutamideThe serum concentration of Ketoconazole can be decreased when it is combined with Enzalutamide.Approved
EperisoneThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Eperisone.Approved, Investigational
EpinastineThe serum concentration of Ketoconazole can be decreased when it is combined with Epinastine.Approved, Investigational
EpinastineThe metabolism of Epinastine can be decreased when combined with Ketoconazole.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Ketoconazole.Approved
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Ketoconazole.Approved
EquileninThe serum concentration of Equilenin can be increased when it is combined with Ketoconazole.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Ketoconazole.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Ketoconazole.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Ketoconazole.Approved
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Ketoconazole.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Ketoconazole.Approved
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Ketoconazole.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Ketoconazole.Approved
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Ketoconazole.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Ketoconazole.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Ketoconazole.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Ketoconazole.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Ketoconazole can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Ketoconazole.Investigational
EsomeprazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Esomeprazole.Approved, Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Ketoconazole.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Ketoconazole.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Ketoconazole.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Ketoconazole.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Ketoconazole.Approved
EstriolThe serum concentration of Ketoconazole can be decreased when it is combined with Estriol.Approved, Vet Approved
EstroneThe metabolism of Estrone can be decreased when combined with Ketoconazole.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Ketoconazole.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Ketoconazole.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Ketoconazole.Approved
EthanolThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Ethanol.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Ketoconazole.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Ketoconazole.Approved
Ethyl biscoumacetateThe serum concentration of Ethyl biscoumacetate can be increased when it is combined with Ketoconazole.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Ketoconazole.Approved, Illicit
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Ketoconazole.Approved
EtodolacThe metabolism of Etodolac can be decreased when combined with Ketoconazole.Approved, Investigational, Vet Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Ketoconazole.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Ketoconazole.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Ketoconazole.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Ketoconazole.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Ketoconazole.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Ketoconazole.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Ketoconazole.Approved
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Ketoconazole.Approved
FamotidineThe serum concentration of Ketoconazole can be decreased when it is combined with Famotidine.Approved
FamotidineThe metabolism of Famotidine can be decreased when combined with Ketoconazole.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Ketoconazole.Approved
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Ketoconazole.Approved, Investigational
FelodipineThe metabolism of Felodipine can be decreased when combined with Ketoconazole.Approved, Investigational
FendilineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Fendiline.Withdrawn
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Ketoconazole.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Ketoconazole.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Ketoconazole.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Ketoconazole.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Ketoconazole.Approved
FimasartanThe serum concentration of Fimasartan can be increased when it is combined with Ketoconazole.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Ketoconazole.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Ketoconazole.Approved, Investigational
FingolimodThe serum concentration of the active metabolites of Fingolimod can be increased when Fingolimod is used in combination with Ketoconazole.Approved, Investigational
FlecainideKetoconazole may increase the QTc-prolonging activities of Flecainide.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Ketoconazole.Approved
fluasteroneThe serum concentration of fluasterone can be increased when it is combined with Ketoconazole.Investigational
FluconazoleThe metabolism of Ketoconazole can be decreased when combined with Fluconazole.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Ketoconazole.Approved
FluindioneThe serum concentration of Fluindione can be increased when it is combined with Ketoconazole.Investigational
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Ketoconazole.Approved, Vet Approved
FlunarizineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Flunarizine.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Ketoconazole.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Ketoconazole.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Ketoconazole.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Ketoconazole.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Ketoconazole.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Ketoconazole.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Ketoconazole.Approved, Vet Approved
FlupentixolKetoconazole may increase the QTc-prolonging activities of Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Ketoconazole can be increased when it is combined with Fluphenazine.Approved
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Ketoconazole.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Ketoconazole.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Ketoconazole.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Ketoconazole.Approved, Illicit
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Ketoconazole.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Ketoconazole.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Ketoconazole.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Ketoconazole.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Ketoconazole.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Ketoconazole.Approved
FluvoxamineThe metabolism of Ketoconazole can be decreased when combined with Fluvoxamine.Approved, Investigational
FormestaneThe serum concentration of Formestane can be increased when it is combined with Ketoconazole.Approved, Investigational, Withdrawn
FormoterolThe metabolism of Formoterol can be decreased when combined with Ketoconazole.Approved, Investigational
FosamprenavirThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Ketoconazole.Approved
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Ketoconazole.Approved
FosaprepitantThe serum concentration of Ketoconazole can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Ketoconazole can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Ketoconazole.Approved, Investigational
Fusidic AcidThe serum concentration of Ketoconazole can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Gabapentin.Approved, Investigational
Gadobenic acidKetoconazole may increase the QTc-prolonging activities of Gadobenic acid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Ketoconazole.Approved
GallopamilThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Gallopamil.Investigational
GavestinelThe metabolism of Gavestinel can be decreased when combined with Ketoconazole.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Ketoconazole.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Ketoconazole.Approved
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Ketoconazole.Approved
GemifloxacinKetoconazole may increase the QTc-prolonging activities of Gemifloxacin.Approved, Investigational
GenisteinThe serum concentration of Ketoconazole can be increased when it is combined with Genistein.Investigational
GliclazideThe metabolism of Gliclazide can be decreased when combined with Ketoconazole.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Ketoconazole.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Ketoconazole.Approved
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Ketoconazole.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Ketoconazole.Approved
GlycerolThe serum concentration of Ketoconazole can be increased when it is combined with Glycerol.Experimental
GoserelinKetoconazole may increase the QTc-prolonging activities of Goserelin.Approved
Gramicidin DThe serum concentration of Ketoconazole can be increased when it is combined with Gramicidin D.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Ketoconazole.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Ketoconazole.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Ketoconazole.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Ketoconazole.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Ketoconazole.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Ketoconazole.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Ketoconazole.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be increased when it is combined with Ketoconazole.Investigational
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Ketoconazole.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Ketoconazole.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Ketoconazole.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Ketoconazole.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Ketoconazole.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Ketoconazole.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Ketoconazole.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Ketoconazole.Approved
IbutilideKetoconazole may increase the QTc-prolonging activities of Ibutilide.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Ketoconazole.Approved
IdelalisibThe serum concentration of Ketoconazole can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Ketoconazole resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Ketoconazole.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Ketoconazole.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Ketoconazole.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Ketoconazole.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Ketoconazole.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Ketoconazole.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Ketoconazole.Approved
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Ketoconazole.Approved
IndinavirThe metabolism of Ketoconazole can be decreased when combined with Indinavir.Approved
indisulamThe metabolism of indisulam can be decreased when combined with Ketoconazole.Investigational
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Ketoconazole.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Ketoconazole.Approved
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Ketoconazole.Approved, Investigational
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Ketoconazole.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Ketoconazole.Approved, Investigational
IsoniazidThe serum concentration of Ketoconazole can be decreased when it is combined with Isoniazid.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Ketoconazole.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Ketoconazole.Approved
IsradipineThe metabolism of Isradipine can be decreased when combined with Ketoconazole.Approved
IstaroximeThe serum concentration of Istaroxime can be increased when it is combined with Ketoconazole.Investigational
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Ketoconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Ketoconazole.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Ketoconazole.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Ketoconazole.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Ketoconazole.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Ketoconazole.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Ketoconazole.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Ketoconazole.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Ketoconazole.Approved
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Ketoconazole.Approved, Vet Approved
LabetalolThe metabolism of Labetalol can be decreased when combined with Ketoconazole.Approved
LacidipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Lacidipine.Approved
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Ketoconazole.Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Ketoconazole.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Lamotrigine.Approved, Investigational
LansoprazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Lansoprazole.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Ketoconazole.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Ketoconazole.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Ketoconazole.Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Ketoconazole.Approved
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Ketoconazole.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Ketoconazole.Approved
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Ketoconazole.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Ketoconazole.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Ketoconazole.Approved
LetrozoleThe metabolism of Letrozole can be decreased when combined with Ketoconazole.Approved, Investigational
LeuprolideKetoconazole may increase the QTc-prolonging activities of Leuprolide.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Ketoconazole.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Ketoconazole.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Ketoconazole.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Ketoconazole.Approved
LevofloxacinKetoconazole may increase the QTc-prolonging activities of Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Ketoconazole.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Ketoconazole.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Ketoconazole.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Ketoconazole.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Ketoconazole.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Ketoconazole.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Ketoconazole.Approved
LiothyronineThe serum concentration of Ketoconazole can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Ketoconazole can be decreased when it is combined with Liotrix.Approved
LisinoprilThe serum concentration of Ketoconazole can be increased when it is combined with Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Ketoconazole.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Ketoconazole.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Ketoconazole.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Ketoconazole.Approved
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Ketoconazole.Approved
LopinavirThe metabolism of Lopinavir can be decreased when combined with Ketoconazole.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Ketoconazole.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Ketoconazole.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Ketoconazole.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Ketoconazole.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Ketoconazole.Approved, Investigational
LuliconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Ketoconazole can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Ketoconazole.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Ketoconazole.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Ketoconazole.Approved
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Ketoconazole.Approved
MagaldrateThe serum concentration of Ketoconazole can be decreased when it is combined with Magaldrate.Withdrawn
Magnesium carbonateThe serum concentration of Ketoconazole can be decreased when it is combined with Magnesium carbonate.Approved
Magnesium hydroxideThe serum concentration of Ketoconazole can be decreased when it is combined with Magnesium hydroxide.Approved
Magnesium oxideThe serum concentration of Ketoconazole can be decreased when it is combined with Magnesium oxide.Approved
Magnesium SulfateThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Magnesium Sulfate.Approved, Vet Approved
Magnesium TrisilicateThe serum concentration of Ketoconazole can be decreased when it is combined with Magnesium Trisilicate.Approved
ManidipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Manidipine.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Ketoconazole.Approved, Investigational
MaprotilineThe serum concentration of Ketoconazole can be increased when it is combined with Maprotiline.Approved
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Ketoconazole.Approved, Investigational
ME-609The serum concentration of ME-609 can be increased when it is combined with Ketoconazole.Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Ketoconazole.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Ketoconazole.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Ketoconazole.Approved
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Ketoconazole.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Ketoconazole.Approved
Megestrol acetateThe serum concentration of Ketoconazole can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Ketoconazole.Approved, Nutraceutical, Vet Approved
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Ketoconazole.Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Ketoconazole.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Ketoconazole.Investigational, Withdrawn
MeprobamateThe serum concentration of Ketoconazole can be increased when it is combined with Meprobamate.Approved, Illicit
MequitazineThe metabolism of Mequitazine can be decreased when combined with Ketoconazole.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Ketoconazole.Approved
MestranolThe metabolism of Mestranol can be decreased when combined with Ketoconazole.Approved
MethadoneThe serum concentration of Methadone can be increased when it is combined with Ketoconazole.Approved
MethadoneThe metabolism of Methadone can be decreased when combined with Ketoconazole.Approved
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Ketoconazole.Approved, Illicit
MethanthelineThe serum concentration of Ketoconazole can be decreased when it is combined with Methantheline.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Ketoconazole.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Ketoconazole.Approved
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Ketoconazole.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Ketoconazole.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Ketoconazole.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Ketoconazole.Approved
MethylergometrineThe serum concentration of Methylergometrine can be increased when it is combined with Ketoconazole.Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Ketoconazole.Approved, Investigational
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Ketoconazole.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Ketoconazole.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Ketoconazole.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Ketoconazole.Approved, Illicit, Withdrawn
MetiamideThe serum concentration of Ketoconazole can be decreased when it is combined with Metiamide.Experimental
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Ketoconazole.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Ketoconazole.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Ketoconazole.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Ketoconazole.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Ketoconazole.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Ketoconazole.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Ketoconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Ketoconazole.Approved, Illicit
MidazolamThe metabolism of Midazolam can be decreased when combined with Ketoconazole.Approved, Illicit
MifepristoneMifepristone may increase the QTc-prolonging activities of Ketoconazole.Approved, Investigational
MinaprineThe metabolism of Minaprine can be decreased when combined with Ketoconazole.Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Ketoconazole.Approved
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Ketoconazole.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Ketoconazole.Approved
MitomycinThe serum concentration of Ketoconazole can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Ketoconazole can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Ketoconazole can be decreased when it is combined with Mitoxantrone.Approved, Investigational
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Ketoconazole.Approved
ModafinilThe metabolism of Modafinil can be decreased when combined with Ketoconazole.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Ketoconazole.Approved, Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Ketoconazole.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Ketoconazole.Approved, Investigational
MoxifloxacinKetoconazole may increase the QTc-prolonging activities of Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Ketoconazole.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Ketoconazole.Approved
NafcillinThe serum concentration of Ketoconazole can be decreased when it is combined with Nafcillin.Approved
NaftopidilThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Naftopidil.Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Ketoconazole.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Ketoconazole.Approved, Vet Approved
NaltrexoneThe serum concentration of Ketoconazole can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Ketoconazole.Approved, Vet Approved
NaringeninThe serum concentration of Ketoconazole can be increased when it is combined with Naringenin.Experimental
NateglinideThe metabolism of Nateglinide can be decreased when combined with Ketoconazole.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Ketoconazole.Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Ketoconazole.Approved, Investigational
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Ketoconazole.Approved, Withdrawn
NelfinavirThe metabolism of Ketoconazole can be decreased when combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Ketoconazole can be increased when it is combined with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Ketoconazole can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Ketoconazole can be decreased when it is combined with Nevirapine.Approved
NevirapineThe metabolism of Ketoconazole can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Ketoconazole.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Ketoconazole.Approved
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Ketoconazole.Approved, Vet Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Ketoconazole.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Ketoconazole.Approved
NiguldipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Niguldipine.Experimental
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Ketoconazole.Approved, Investigational
NiludipineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Niludipine.Experimental
NilutamideThe metabolism of Nilutamide can be decreased when combined with Ketoconazole.Approved
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Ketoconazole.Approved
NimesulideThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Nimesulide.Approved, Withdrawn
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Ketoconazole.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Ketoconazole.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Ketoconazole.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Ketoconazole.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Ketoconazole.Approved
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Ketoconazole.Approved, Vet Approved
NizatidineThe serum concentration of Ketoconazole can be decreased when it is combined with Nizatidine.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Ketoconazole.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Ketoconazole.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Ketoconazole.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Ketoconazole.Approved
OfloxacinKetoconazole may increase the QTc-prolonging activities of Ofloxacin.Approved
OlanzapineThe serum concentration of Ketoconazole can be decreased when it is combined with Olanzapine.Approved, Investigational
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Ketoconazole.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Ketoconazole.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be increased when it is combined with Ketoconazole.Investigational
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Ketoconazole.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Ketoconazole.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Ketoconazole.Approved
OmeprazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Ketoconazole.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Ketoconazole.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Ketoconazole.Approved
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Ketoconazole.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Ketoconazole.Approved
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Ketoconazole.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Ketoconazole.Approved
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Ketoconazole.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Ketoconazole.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Ketoconazole.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Ketoconazole can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Ketoconazole.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Ketoconazole.Approved
PaliperidoneKetoconazole may increase the QTc-prolonging activities of Paliperidone.Approved
Palmitic AcidThe serum concentration of Ketoconazole can be increased when it is combined with Palmitic Acid.Experimental
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Ketoconazole.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Ketoconazole.Approved, Investigational
PantoprazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Pantoprazole.Approved
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Ketoconazole.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Ketoconazole.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Ketoconazole.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Ketoconazole.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Ketoconazole.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Ketoconazole.Approved
ParoxetineThe serum concentration of Ketoconazole can be increased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Ketoconazole.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Ketoconazole.Approved
PentobarbitalThe metabolism of Ketoconazole can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Ketoconazole.Approved
PerflutrenKetoconazole may increase the QTc-prolonging activities of Perflutren.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Ketoconazole.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Ketoconazole.Approved
PerindoprilThe serum concentration of Ketoconazole can be increased when it is combined with Perindopril.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Ketoconazole.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Ketoconazole.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Ketoconazole.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Ketoconazole.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Ketoconazole.Approved, Withdrawn
PhenindioneThe serum concentration of Phenindione can be increased when it is combined with Ketoconazole.Approved
PhenobarbitalThe metabolism of Ketoconazole can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Ketoconazole.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Ketoconazole.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Ketoconazole.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Ketoconazole.Approved, Vet Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Ketoconazole.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Ketoconazole.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Ketoconazole.Approved, Investigational
PimozideKetoconazole may increase the arrhythmogenic activities of Pimozide.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Ketoconazole.Withdrawn
PinaveriumThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Pinaverium.Approved
PindololThe metabolism of Pindolol can be decreased when combined with Ketoconazole.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Ketoconazole.Approved, Investigational
PiperazineThe metabolism of Piperazine can be decreased when combined with Ketoconazole.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Ketoconazole.Approved
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Ketoconazole.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Ketoconazole.Approved
Platelet Activating FactorThe serum concentration of Ketoconazole can be decreased when it is combined with Platelet Activating Factor.Experimental
PodofiloxThe metabolism of Podofilox can be decreased when combined with Ketoconazole.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Ketoconazole.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Ketoconazole.Approved
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Ketoconazole.Approved, Investigational, Vet Approved
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Ketoconazole.Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Ketoconazole.Approved, Nutraceutical
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Ketoconazole resulting in a loss in efficacy.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Ketoconazole.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Ketoconazole.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Ketoconazole.Approved, Vet Approved
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Ketoconazole.Approved, Vet Approved
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Ketoconazole.Approved
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Ketoconazole.Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Ketoconazole.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Ketoconazole.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Ketoconazole.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Pregabalin.Approved, Illicit, Investigational
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Ketoconazole.Experimental
PrenylamineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Prenylamine.Withdrawn
PrimaquineThe metabolism of Primaquine can be decreased when combined with Ketoconazole.Approved
PrimidoneThe metabolism of Ketoconazole can be increased when combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Ketoconazole can be increased when it is combined with Probenecid.Approved
ProcainamideKetoconazole may increase the QTc-prolonging activities of Procainamide.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Ketoconazole.Approved, Vet Approved
ProgesteroneThe therapeutic efficacy of Progesterone can be decreased when used in combination with Ketoconazole.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Ketoconazole.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Ketoconazole.Approved, Vet Approved
PromethazineThe serum concentration of Ketoconazole can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Ketoconazole can be increased when it is combined with Propafenone.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Ketoconazole.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Ketoconazole.Approved, Investigational
ProtriptylineThe serum concentration of Ketoconazole can be increased when it is combined with Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Ketoconazole.Approved
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Ketoconazole.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Ketoconazole.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Ketoconazole.Approved, Illicit
QuercetinThe serum concentration of Ketoconazole can be increased when it is combined with Quercetin.Experimental
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Ketoconazole.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Ketoconazole.Approved
QuinidineThe metabolism of Quinidine can be decreased when combined with Ketoconazole.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Ketoconazole.Approved
RabeprazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Rabeprazole.Approved, Investigational
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Ketoconazole.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Ketoconazole.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Ketoconazole.Approved, Investigational
RanitidineThe serum concentration of Ketoconazole can be decreased when it is combined with Ranitidine.Approved
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Ketoconazole.Approved
RanolazineThe metabolism of Ranolazine can be decreased when combined with Ketoconazole.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Ketoconazole.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Ketoconazole.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Ketoconazole.Approved, Withdrawn
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Ketoconazole.Approved, Investigational
repinotanThe metabolism of repinotan can be decreased when combined with Ketoconazole.Investigational
ReserpineThe serum concentration of Ketoconazole can be decreased when it is combined with Reserpine.Approved
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Ketoconazole.Approved
RifabutinThe metabolism of Ketoconazole can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Ketoconazole can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Ketoconazole can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Ketoconazole.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Ketoconazole.Approved
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Ketoconazole.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Ketoconazole.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Ketoconazole.Approved
RiociguatThe metabolism of Riociguat can be decreased when combined with Ketoconazole.Approved
RisedronateThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Risedronate.Approved, Investigational
RisperidoneThe metabolism of Risperidone can be decreased when combined with Ketoconazole.Approved, Investigational
RitonavirThe serum concentration of Ketoconazole can be increased when it is combined with Ritonavir.Approved, Investigational
RitonavirThe metabolism of Ketoconazole can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Ketoconazole.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Ketoconazole.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Ketoconazole.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Ketoconazole.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Ketoconazole.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Ketoconazole.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Ketoconazole.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Ketoconazole.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Ketoconazole.Approved
Roxatidine acetateThe serum concentration of Ketoconazole can be decreased when it is combined with Roxatidine acetate.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Ketoconazole.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Ketoconazole.Approved
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Ketoconazole.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Ketoconazole.Approved
SaquinavirThe serum concentration of Ketoconazole can be increased when it is combined with Saquinavir.Approved, Investigational
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Ketoconazole.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Ketoconazole.Approved
ScopolamineThe serum concentration of Ketoconazole can be increased when it is combined with Scopolamine.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Ketoconazole.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Ketoconazole.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Ketoconazole.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Ketoconazole.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Ketoconazole.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Ketoconazole.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Ketoconazole.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Ketoconazole.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Ketoconazole.Approved
SiltuximabThe serum concentration of Ketoconazole can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Ketoconazole.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Ketoconazole.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Ketoconazole.Approved, Investigational
SirolimusThe metabolism of Sirolimus can be decreased when combined with Ketoconazole.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Ketoconazole.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Ketoconazole.Approved, Investigational, Withdrawn
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Ketoconazole.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Ketoconazole.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Ketoconazole.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Ketoconazole.Approved, Investigational
SotalolKetoconazole may increase the QTc-prolonging activities of Sotalol.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Ketoconazole.Approved
SparteineThe metabolism of Sparteine can be decreased when combined with Ketoconazole.Experimental
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Ketoconazole.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Ketoconazole.Approved
SpironolactoneThe serum concentration of Ketoconazole can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Ketoconazole can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Ketoconazole can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Ketoconazole can be increased when it is combined with Stiripentol.Approved
StreptozocinThe serum concentration of Ketoconazole can be decreased when it is combined with Streptozocin.Approved
SucralfateSucralfate can cause a decrease in the absorption of Ketoconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Ketoconazole.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Ketoconazole.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Ketoconazole.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Ketoconazole.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Ketoconazole.Approved
SulfisoxazoleKetoconazole may increase the QTc-prolonging activities of Sulfisoxazole.Approved, Vet Approved
SumatriptanThe serum concentration of Ketoconazole can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe metabolism of Sunitinib can be decreased when combined with Ketoconazole.Approved, Investigational
SuprofenThe metabolism of Suprofen can be decreased when combined with Ketoconazole.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Ketoconazole.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Ketoconazole.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Ketoconazole.Approved
TacrineThe serum concentration of Ketoconazole can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Ketoconazole.Approved, Investigational
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Ketoconazole.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Ketoconazole.Approved, Investigational
TAK-390MRThe serum concentration of Ketoconazole can be decreased when it is combined with TAK-390MR.Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Ketoconazole resulting in a loss in efficacy.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Ketoconazole.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Ketoconazole.Approved
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Ketoconazole.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Ketoconazole.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Ketoconazole.Experimental
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Ketoconazole.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ketoconazole.Approved
TegaserodThe metabolism of Tegaserod can be decreased when combined with Ketoconazole.Investigational, Withdrawn
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Ketoconazole.Approved
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Ketoconazole.Approved
TelavancinKetoconazole may increase the QTc-prolonging activities of Telavancin.Approved
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Ketoconazole.Approved
TelithromycinThe metabolism of Ketoconazole can be decreased when combined with Telithromycin.Approved
TelmisartanThe serum concentration of Ketoconazole can be increased when it is combined with Telmisartan.Approved, Investigational
TemazepamThe metabolism of Temazepam can be decreased when combined with Ketoconazole.Approved
TemsirolimusThe serum concentration of the active metabolites of Temsirolimus can be increased when Temsirolimus is used in combination with Ketoconazole.Approved
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Ketoconazole.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Ketoconazole.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Ketoconazole.Approved
TerazosinThe serum concentration of Ketoconazole can be increased when it is combined with Terazosin.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Ketoconazole.Approved, Investigational, Vet Approved
TerfenadineKetoconazole may increase the QTc-prolonging activities of Terfenadine.Withdrawn
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Ketoconazole.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Ketoconazole.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Ketoconazole.Approved, Investigational
TetrabenazineKetoconazole may increase the QTc-prolonging activities of Tetrabenazine.Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Ketoconazole.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Ketoconazole.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be decreased when combined with Ketoconazole.Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Ketoconazole.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Ketoconazole.Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Ketoconazole.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Ketoconazole.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Ketoconazole resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Ketoconazole.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Ketoconazole.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Ketoconazole.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Ketoconazole.Approved
TipranavirThe serum concentration of Ketoconazole can be increased when it is combined with Tipranavir.Approved, Investigational
TipranavirThe metabolism of Tipranavir can be decreased when combined with Ketoconazole.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Ketoconazole.Approved
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Ketoconazole.Approved
TocilizumabThe serum concentration of Ketoconazole can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Ketoconazole.Approved, Investigational
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Ketoconazole.Approved
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Tolfenamic Acid.Approved
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Ketoconazole.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Ketoconazole.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Ketoconazole.Approved, Investigational
TorasemideThe metabolism of Torasemide can be decreased when combined with Ketoconazole.Approved
ToremifeneThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Toremifene.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Ketoconazole.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Ketoconazole.Approved, Investigational
TranilastThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Tranilast.Approved, Investigational
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Ketoconazole.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Ketoconazole.Approved, Investigational
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Ketoconazole.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Ketoconazole.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Ketoconazole.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Ketoconazole.Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Ketoconazole.Approved
TrifluoperazineThe serum concentration of Ketoconazole can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Ketoconazole can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Ketoconazole.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Ketoconazole.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Ketoconazole.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Ketoconazole.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Ketoconazole.Approved
UdenafilThe metabolism of Udenafil can be decreased when combined with Ketoconazole.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Ketoconazole.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Ketoconazole.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Ketoconazole.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Ketoconazole.Approved, Investigational
ValsartanThe metabolism of Valsartan can be decreased when combined with Ketoconazole.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Ketoconazole.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Ketoconazole.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Ketoconazole.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Ketoconazole.Approved
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Ketoconazole.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Ketoconazole.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Ketoconazole.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Ketoconazole.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Ketoconazole.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Ketoconazole.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Ketoconazole.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Ketoconazole.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Ketoconazole.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Ketoconazole.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Ketoconazole.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Ketoconazole.Approved, Investigational
VinpocetineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Vinpocetine.Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Ketoconazole.Approved
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Ketoconazole.Approved
VoriconazoleThe metabolism of Ketoconazole can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Ketoconazole.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Ketoconazole.Approved
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Ketoconazole.Approved
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Ketoconazole.Approved, Investigational, Withdrawn
XylometazolineThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Xylometazoline.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Ketoconazole.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Ketoconazole.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Ketoconazole.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Ketoconazole.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Ketoconazole.Approved
ZiconotideThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Ziconotide.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Ketoconazole.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Ketoconazole.Approved, Investigational, Withdrawn
ZimelidineThe serum concentration of Ketoconazole can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Ketoconazole.Approved
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Ketoconazole.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Ketoconazole.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Ketoconazole.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Ketoconazole.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Ketoconazole.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
  • Take with food.
References
Synthesis Reference

U.S. Patent 4,144,346.

General References
  1. Goeders NE, Peltier RL, Guerin GF: Ketoconazole reduces low dose cocaine self-administration in rats. Drug Alcohol Depend. 1998 Dec 1;53(1):67-77. [PubMed:10933341 ]
  2. Berwaerts J, Verhelst J, Mahler C, Abs R: Cushing's syndrome in pregnancy treated by ketoconazole: case report and review of the literature. Gynecol Endocrinol. 1999 Jun;13(3):175-82. [PubMed:10451809 ]
  3. Kazy Z, Puho E, Czeizel AE: Population-based case-control study of oral ketoconazole treatment for birth outcomes. Congenit Anom (Kyoto). 2005 Mar;45(1):5-8. [PubMed:15737124 ]
  4. Pierard-Franchimont C, Goffin V, Decroix J, Pierard GE: A multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitis. Skin Pharmacol Appl Skin Physiol. 2002 Nov-Dec;15(6):434-41. [PubMed:12476017 ]
External Links
ATC CodesD01AC08G01AF11J02AB02
AHFS Codes
  • 08:14.08
  • 84:04.08.08
PDB EntriesNot Available
FDA labelDownload (222 KB)
MSDSDownload (73.3 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9156
Blood Brain Barrier+0.6704
Caco-2 permeable+0.8866
P-glycoprotein substrateSubstrate0.7293
P-glycoprotein inhibitor IInhibitor0.8389
P-glycoprotein inhibitor IIInhibitor0.8388
Renal organic cation transporterNon-inhibitor0.5644
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateSubstrate0.7409
CYP450 1A2 substrateInhibitor0.9106
CYP450 2C9 inhibitorInhibitor0.8949
CYP450 2D6 inhibitorInhibitor0.8931
CYP450 2C19 inhibitorInhibitor0.8994
CYP450 3A4 inhibitorInhibitor0.796
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9386
Ames testNon AMES toxic0.7003
CarcinogenicityNon-carcinogens0.8836
BiodegradationNot ready biodegradable1.0
Rat acute toxicity3.4739 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9258
hERG inhibition (predictor II)Inhibitor0.8403
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Aerosol, foamTopical20 mg/g
Aerosol, foamTopical2 g/100g
CreamTopical20 mg/g
CreamTopical20 mg/1
ShampooTopical20 mg/mL
Shampoo, suspensionTopical20 mg/mL
Shampoo, suspensionTopical20.5 mg/mL
TabletOral200 mg/1
Kit
CreamTopical2 %
ShampooTopical2 %
ShampooTopical10 mg/mL
SuspensionOral20 mg
TabletOral200 mg
GelTopical2 %
GelTopical20 mg/g
Prices
Unit descriptionCostUnit
Extina 2% Foam 100 gm Can375.44USD can
Extina 2% Foam 50 gm Can201.53USD can
Nizoral 2% Shampoo 120ml Bottle49.43USD bottle
Ketoconazole 2% Cream 60 gm Tube44.72USD tube
Ketoconazole 2% Cream 30 gm Tube29.43USD tube
Ketoconazole 2% Shampoo 120ml Bottle27.98USD bottle
Ketoconazole 2% Cream 15 gm Tube19.99USD tube
Ketoconazole powder15.0USD g
Nizoral 200 mg tablet4.75USD tablet
Extina 2% foam3.61USD g
Ketoconazole 200 mg tablet3.21USD tablet
Kuric 2% cream1.54USD g
Apo-Ketoconazole 200 mg Tablet1.24USD tablet
Novo-Ketoconazole 200 mg Tablet1.24USD tablet
Nu-Ketocon 200 mg Tablet1.24USD tablet
Nizoral 2% cream1.22USD g
Ketoconazole 2% cream1.1USD g
Ketoderm 2 % Cream0.35USD g
Ketoconazole 2% shampoo0.23USD ml
Nizoral a-d 1% shampoo0.07USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5456851 No1994-04-072014-04-07Us
US7179475 No1998-12-042018-12-04Us
US7553835 No1998-10-192018-10-19Us
US8026238 No1998-10-192018-10-19Us
US8232276 No2000-11-242020-11-24Us
US8735393 No1998-12-042018-12-04Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point146U.S. Patent 4,144,346.
water solubility0.0866 mg/LNot Available
logP4.35SANGSTER (1993)
Predicted Properties
PropertyValueSource
Water Solubility0.00931 mg/mLALOGPS
logP4.3ALOGPS
logP4.19ChemAxon
logS-4.8ALOGPS
pKa (Strongest Basic)6.75ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area69.06 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity138.07 m3·mol-1ChemAxon
Polarizability54.83 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassDiazinanes
Sub ClassPiperazines
Direct ParentPhenylpiperazines
Alternative Parents
Substituents
  • N-arylpiperazine
  • Phenylpiperazine
  • Substituted aniline
  • Dialkylarylamine
  • Phenol ether
  • 1,3-dichlorobenzene
  • Glycerol ether
  • Halobenzene
  • Chlorobenzene
  • Aniline
  • Alkyl aryl ether
  • Benzenoid
  • N-substituted imidazole
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Acetamide
  • Tertiary carboxylic acid amide
  • Imidazole
  • Azole
  • Meta-dioxolane
  • Tertiary amine
  • Carboxamide group
  • Oxacycle
  • Azacycle
  • Ether
  • Carboxylic acid derivative
  • Acetal
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Yeast
Pharmacological action
yes
Actions
inhibitor
General Function:
Sterol 14-demethylase activity
Specific Function:
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name:
ERG11
Uniprot ID:
P10613
Molecular Weight:
60674.965 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Agut J, Palacin C, Sacristan A, Ortiz JA: Inhibition of ergosterol synthesis by sertaconazole in Candida albicans. Arzneimittelforschung. 1992 May;42(5A):718-20. [PubMed:1627190 ]
  4. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
  5. Agut J, Palacin C, Salgado J, Casas E, Sacristan A, Ortiz JA: Direct membrane-damaging effect of sertaconazole on Candida albicans as a mechanism of its fungicidal activity. Arzneimittelforschung. 1992 May;42(5A):721-4. [PubMed:1627191 ]
  6. Croxtall JD, Plosker GL: Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynaecology. Drugs. 2009;69(3):339-59. doi: 10.2165/00003495-200969030-00009. [PubMed:19275277 ]
  7. Borgers M, Degreef H, Cauwenbergh G: Fungal infections of the skin: infection process and antimycotic therapy. Curr Drug Targets. 2005 Dec;6(8):849-62. [PubMed:16375669 ]
  8. Warrilow AG, Martel CM, Parker JE, Melo N, Lamb DC, Nes WD, Kelly DE, Kelly SL: Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrob Agents Chemother. 2010 Oct;54(10):4235-45. doi: 10.1128/AAC.00587-10. Epub 2010 Jul 12. [PubMed:20625155 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Zinc ion binding
Specific Function:
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Gene Name:
AR
Uniprot ID:
P10275
Molecular Weight:
98987.9 Da
References
  1. Eil C: Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24(8):367-70. [PubMed:1526623 ]
3. 17-hydroxylase 
Kind
Protein
Organism
Human
Pharmacological action
unknown
References
  1. Trachtenberg J, Zadra J: Steroid synthesis inhibition by ketoconazole: sites of action. Clin Invest Med. 1988 Feb;11(1):1-5. [PubMed:2966691 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Steroid hydroxylase activity
Specific Function:
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.
Gene Name:
CYP21A2
Uniprot ID:
P08686
Molecular Weight:
55886.805 Da
References
  1. Trachtenberg J, Zadra J: Steroid synthesis inhibition by ketoconazole: sites of action. Clin Invest Med. 1988 Feb;11(1):1-5. [PubMed:2966691 ]
5. 11-hydroxylase
Kind
Protein
Organism
Human
Pharmacological action
unknown
References
  1. Trachtenberg J, Zadra J: Steroid synthesis inhibition by ketoconazole: sites of action. Clin Invest Med. 1988 Feb;11(1):1-5. [PubMed:2966691 ]
  2. Loose DS, Kan PB, Hirst MA, Marcus RA, Feldman D: Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Invest. 1983 May;71(5):1495-9. [PubMed:6304148 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Oxygen binding
Specific Function:
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Gene Name:
CYP19A1
Uniprot ID:
P11511
Molecular Weight:
57882.48 Da
References
  1. Weber MM, Will A, Adelmann B, Engelhardt D: Effect of ketoconazole on human ovarian C17,20-desmolase and aromatase. J Steroid Biochem Mol Biol. 1991 Feb;38(2):213-8. [PubMed:2004042 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Sakaeda T, Iwaki K, Kakumoto M, Nishikawa M, Niwa T, Jin JS, Nakamura T, Nishiguchi K, Okamura N, Okumura K: Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs. J Pharm Pharmacol. 2005 Jun;57(6):759-64. [PubMed:15969931 ]
  2. Elsherbiny ME, El-Kadi AO, Brocks DR: The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. J Pharm Pharm Sci. 2008;11(1):147-59. [PubMed:18445370 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Elsherbiny ME, El-Kadi AO, Brocks DR: The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. J Pharm Pharm Sci. 2008;11(1):147-59. [PubMed:18445370 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
Specific Function:
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Gene Name:
CYP11A1
Uniprot ID:
P05108
Molecular Weight:
60101.87 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid 11-beta-monooxygenase activity
Specific Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Gene Name:
CYP11B1
Uniprot ID:
P15538
Molecular Weight:
57572.44 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compou...
Gene Name:
CYP1B1
Uniprot ID:
Q16678
Molecular Weight:
60845.33 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Retinoic acid binding
Specific Function:
Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.
Gene Name:
CYP26A1
Uniprot ID:
O43174
Molecular Weight:
56198.11 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sterol 14-demethylase activity
Specific Function:
Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name:
CYP51A1
Uniprot ID:
Q16850
Molecular Weight:
56805.26 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name:
ABCB11
Uniprot ID:
O95342
Molecular Weight:
146405.83 Da
References
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. [PubMed:12739759 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB: Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 2000 Jun;28(6):655-60. [PubMed:10820137 ]
  2. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514 ]
  3. Wang EJ, Lew K, Casciano CN, Clement RP, Johnson WW: Interaction of common azole antifungals with P glycoprotein. Antimicrob Agents Chemother. 2002 Jan;46(1):160-5. [PubMed:11751127 ]
  4. Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. [PubMed:11961113 ]
  5. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
  6. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103 ]
  7. Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. [PubMed:12235267 ]
  8. Dahan A, Sabit H, Amidon GL: The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport. AAPS J. 2009 Jun;11(2):205-13. doi: 10.1208/s12248-009-9092-5. Epub 2009 Mar 25. [PubMed:19319690 ]
  9. Takano M, Hasegawa R, Fukuda T, Yumoto R, Nagai J, Murakami T: Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells. Eur J Pharmacol. 1998 Oct 9;358(3):289-94. [PubMed:9822896 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
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Drug created on June 13, 2005 07:24 / Updated on December 07, 2016 02:38