Tardive Dyskinesia

Also known as: Dyskinesia tardive / Drug induced blepharospasm / Lingual-Facial-Buccal Dyskinesia

DrugDrug NameDrug Description
DB01068ClonazepamA benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop [FDA Label] [L5572, F3763, F3787, F3796]. The agent has also been indicated for treating panic disorder [FDA Label] [A175438, L5572, F3763, F3787, F3796]. The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses [FDA Label] [A175438, A175441, L5572, F3763, F3787, F3796]. Since being first patented in 1960 and then released for sale from Roche in the US in 1975 [T469, T472], clonazepam has experienced a storied history in the treatment of the aforementioned medical conditions. Now available as a generic medication, the agent continues to see exceptionally high use as millions of prescriptions are written for the medication internationally every year. Unfortunately, however, like most benzodiazepines, clonazepam use has also been associated with recreational use and drug abuse [FDA Label] [L5572, F3763, F3787, F3796].
DB04844TetrabenazineA drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008.
DB11915ValbenazineValbenazine (development name NBI-98854) has been used in trials studying the treatment and basic science of Tourette Syndrome and Tardive Dyskinesia. In April, 2017, valbenazine was approved by the FDA (as Ingrezza) as the first and only approved treatment for adults with Tardive Dyskinesia (TD).
DrugDrug NamePhaseStatusCount
DB01404Ginseng1 / 2Completed1
DB00114Pyridoxal phosphate2Terminated1
DB12161Deutetrabenazine2 / 3Completed1
DB00571Propranolol2 / 3Withdrawn1
DB11915Valbenazine2 / 3Active Not Recruiting1
DB12161Deutetrabenazine3Active Not Recruiting1
DB01381Ginkgo biloba3Completed1
DB01065MelatoninNot AvailableCompleted1