Familial Adenomatous Polyposis (FAP)

Also known as: Familial Adenomatous Polyposis / Adenomatous Polyposis Coli / Polyposis coli / Familial polyposis

Drug	Drug Name	Drug Description
DB00482	Celecoxib	An NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis.
DB00605	Sulindac	An NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis.

Drug	Drug Name	Target	Type
DB00482	Celecoxib	Prostaglandin G/H synthase 2	target
DB00482	Celecoxib	3-phosphoinositide-dependent protein kinase 1	target
DB00482	Celecoxib	Cytochrome P450 2C9	enzyme
DB00482	Celecoxib	Cytochrome P450 2D6	enzyme
DB00482	Celecoxib	Multidrug resistance-associated protein 4	transporter
DB00482	Celecoxib	Cytochrome P450 3A4	enzyme
DB00482	Celecoxib	Cytochrome P450 2C8	enzyme
DB00482	Celecoxib	Carbonic anhydrase 2	target
DB00482	Celecoxib	Carbonic anhydrase 3	target
DB00482	Celecoxib	Bile salt export pump	transporter
DB00482	Celecoxib	Cadherin-11	target
DB00482	Celecoxib	P-glycoprotein 1	transporter
DB00482	Celecoxib	ATP-binding cassette sub-family G member 2	transporter
DB00605	Sulindac	Prostaglandin G/H synthase 2	target
DB00605	Sulindac	Aldose reductase	target
DB00605	Sulindac	Prostaglandin G/H synthase 1	target
DB00605	Sulindac	Mitogen-activated protein kinase 3	target
DB00605	Sulindac	Peroxisome proliferator-activated receptor delta	target
DB00605	Sulindac	Prostaglandin D2 receptor 2	target
DB00605	Sulindac	Serum albumin	carrier
DB00605	Sulindac	Solute carrier family 22 member 6	transporter
DB00605	Sulindac	Cytochrome P450 1A1	enzyme
DB00605	Sulindac	Aldo-keto reductase family 1 member B10	target

Drug	Drug Name	Phase	Status	Count
DB13134	Fluorine F-18	0	Terminated	1
DB00482	Celecoxib	2	Active Not Recruiting	1
DB00482	Celecoxib	2	Terminated	1
DB11672	Curcumin	2	Completed	1
DB11672	Curcumin	2	Withdrawn	1
DB06243	Eflornithine	2	Terminated	1
DB00530	Erlotinib	2	Active Not Recruiting	1
DB00331	Metformin	2	Recruiting	1
DB14276	Turmeric	2	Completed	1
DB00482	Celecoxib	2 / 3	Completed	1
DB01586	Ursodeoxycholic acid	2 / 3	Completed	1
DB06243	Eflornithine	3	Active Not Recruiting	1
DB06243	Eflornithine	3	Withdrawn	1
DB00159	Icosapent	3	Recruiting	1
DB00605	Sulindac	3	Active Not Recruiting	1
DB00605	Sulindac	3	Withdrawn	1
DB00482	Celecoxib	4	Terminated	1
DB11672	Curcumin	Not Available	Completed	1