Identification

Name
Curcumin
Accession Number
DB11672
Type
Small Molecule
Groups
Approved, Investigational
Description

Curcumin, also known as diferuloylmethane, is an active component in the golden spice turmeric (Curcuma longa) and in Curcuma xanthorrhiza oil. It is a highly pleiotropic molecule that exhibits antibacterial, anti-inflammatory, hypoglycemic, antioxidant, wound-healing, and antimicrobial activities [1]. Due to these properties, curcumin has been investigated for the treatment and supportive care of clinical conditions including proteinuria, breast cancer, multiple myeloma, depression, and Non Small Cell Lung Cancer (NSCLC). Despite proven efficacy against numerous experimental models, poor bioavailability due to poor absorption, rapid metabolism, and rapid systemic elimination have been shown to limit the therapeutic efficacy of curcumin [1]. Curcumin is under investigation for the treatment and supportive care of various clinical conditions including mucositis, rectal cancer, prostate cancer, chronic schizophrenia, and Mild Cognitive Impairment (MCI) [1].

Structure
Thumb
Synonyms
Not Available
External IDs
E 100 / E-100 / E100 / INS NO. 100(I) / INS-100(I) / NSC-32982
Product Ingredients
IngredientUNIICASInChI Key
Curcumin sulfate160DHE331M339286-19-0NEJVQQBBTRFOHB-FCXRPNKRSA-N
Categories
UNII
IT942ZTH98
CAS number
458-37-7
Weight
Average: 368.3799
Monoisotopic: 368.125988372
Chemical Formula
C21H20O6
InChI Key
VFLDPWHFBUODDF-FCXRPNKRSA-N
InChI
InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
IUPAC Name
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
SMILES
COC1=CC(\C=C\C(=O)CC(=O)\C=C\C2=CC(OC)=C(O)C=C2)=CC=C1O

Pharmacology

Indication

No approved therapeutic indications.

Pharmacodynamics

Intravenous application of 25 mg/kg bw curcumin to rats resulted in an increase in bile flow by 80 and 120% [2]. In the rat model of inflammation, curcumin was shown to inhibit edema formation. In nude mouse that had been injected subcutaneously with prostate cancer cells, administration of curcumin caused a marked decrease in the extent of cell proliferation, a significant increase of apoptosis and micro-vessel density [2]. Curcumin may exert choleretic effects by increasing biliary excretion of bile salts, cholesterol, and bilirubin, as well as increasing bile solubility [2]. Curcumin inhibited arachidonic acid-induced platelet aggregation in vitro [2].

Mechanism of action

Curcumin acts as a scavenger of oxygen species, such as hydroxyl radical, superoxide anion, and singlet oxygen and inhibit lipid peroxidation as well as peroxide-induced DNA damage [2]. Curcumin mediates potent anti-inflammatory agent and anti-carcinogenic actions via modulating various signalling molecules. It suppresses a number of key elements in cellular signal transduction pathways pertinent to growth, differentiation, and malignant transformation; it was demonstrated in vitro that curcumin inhibits protein kinases, c-Jun/AP-1 activation, prostaglandin biosynthesis, and the activity and expression of the enzyme cyclooxygenase (COX)-2 [2].

TargetActionsOrganism
UPeroxisome proliferator-activated receptor gammaNot AvailableHuman
UVitamin D3 receptorNot AvailableHuman
UMultidrug resistance-associated protein 5
inhibitor
Human
UCarbonyl reductase [NADPH] 1Not AvailableHuman
UGlutathione S-transferase PNot AvailableHuman
Absorption

Curcumin displays poor absorption into the gastrointestinal tract. In a rat study, oral administration of a single dose of 2 g of curcumin resulted in a plasma concentration of less than 5 μg/mL, indicating poor absorption from the gut [2].

Volume of distribution

Following oral administration of radio-labelled curcumin to rats, radioactivity was detected in the liver and kidneys [2].

Protein binding

No pharmacokinetic data available.

Metabolism

Initially, curcumin undergoes rapid intestinal metabolism to form curcumin glucuronide and curcumin sulfate via O-conjugation. Other metabolites formed include tetrahydrocurcumin, hexahydrocurcumin, and hexahydrocurcuminol via reduction [2]. Curcumin may also undergo intensive second metabolism in the liver where the major metabolites were glucuronides of tetrahydrocurcumin and hexahydrocurcumin, with dihydroferulic acid and traces of ferulic acid as further metabolites [2]. Hepatic metabolites are expected to be excreted in the bile [2]. Certain curcumin metabolites, such as tetrahydrocurcumin, retain anti-inflammatory and antioxidant properties [2].

Route of elimination

Following oral administration of curcumin to rats at a dose of 1 g/kg bw, about 75% of dose was excreted in the faeces and only traces of the compound was detected in the urine [2]. When a single 400 mg dose of curcumin was administered orally to rats, about 60% was absorbed and 40% was excreted unchanged in the faeces over an period of 5 days [2]. Intraperitoneal administration resulted in fecal excretion of 73% and biliary excretion of 11% [2].

Half life

No pharmacokinetic data available.

Clearance

No pharmacokinetic data available.

Toxicity

In an acute oral toxicity study in mouse, LD50 was >2000 mg/kg [MSDS]. Single oral doses of curcumin at 1-5 g/kg bw induced no toxic effects in rats [2]. There has been no cases of overdose reported [2].

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limoneneThe risk or severity of adverse effects can be increased when (4R)-limonene is combined with Curcumin.Investigational
16-BromoepiandrosteroneThe risk or severity of adverse effects can be increased when Curcumin is combined with 16-Bromoepiandrosterone.Investigational
19-norandrostenedioneThe risk or severity of adverse effects can be increased when Curcumin is combined with 19-norandrostenedione.Experimental, Illicit
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Curcumin.Experimental, Illicit
5-androstenedioneThe risk or severity of adverse effects can be increased when Curcumin is combined with 5-androstenedione.Experimental, Illicit
AbciximabCurcumin may increase the anticoagulant activities of Abciximab.Approved
AbemaciclibThe risk or severity of adverse effects can be increased when Curcumin is combined with Abemaciclib.Approved, Investigational
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Curcumin.Approved
AcebutololCurcumin may decrease the antihypertensive activities of Acebutolol.Approved, Investigational
AceclofenacThe risk or severity of adverse effects can be increased when Curcumin is combined with Aceclofenac.Approved, Investigational
AcemetacinThe risk or severity of adverse effects can be increased when Curcumin is combined with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Curcumin.Approved, Investigational
AcetaminophenThe risk or severity of adverse effects can be increased when Curcumin is combined with Acetaminophen.Approved
Acetyl sulfisoxazoleThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Curcumin.Approved, Vet Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Curcumin.Approved
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Curcumin.Approved
AcetyldigoxinAcetyldigoxin may decrease the cardiotoxic activities of Curcumin.Experimental
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Curcumin is combined with Acetylsalicylic acid.Approved, Vet Approved
AdapaleneThe risk or severity of adverse effects can be increased when Adapalene is combined with Curcumin.Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Curcumin.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Curcumin.Approved
AgomelatineThe serum concentration of Agomelatine can be increased when it is combined with Curcumin.Approved, Investigational
AjmalineThe metabolism of Ajmaline can be decreased when combined with Curcumin.Approved, Investigational
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Curcumin.Approved, Vet Approved
AlclofenacThe risk or severity of adverse effects can be increased when Curcumin is combined with Alclofenac.Approved, Withdrawn
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Curcumin.Approved
AldosteroneThe risk or severity of adverse effects can be increased when Curcumin is combined with Aldosterone.Experimental, Investigational
Alendronic acidThe risk or severity of adverse effects can be increased when Curcumin is combined with Alendronic acid.Approved
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Curcumin.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Curcumin.Approved, Investigational
AliskirenCurcumin may decrease the antihypertensive activities of Aliskiren.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Curcumin.Approved
AlminoprofenThe risk or severity of adverse effects can be increased when Curcumin is combined with Alminoprofen.Experimental
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Curcumin.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Curcumin.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Curcumin.Approved, Withdrawn
alpha-Tocopherol acetateThe metabolism of alpha-Tocopherol acetate can be decreased when combined with Curcumin.Approved
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Curcumin.Approved, Illicit, Investigational
AlprenololCurcumin may decrease the antihypertensive activities of Alprenolol.Approved, Withdrawn
AlprostadilThe therapeutic efficacy of Alprostadil can be decreased when used in combination with Curcumin.Approved, Investigational
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Curcumin.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Curcumin.Approved, Investigational
AmcinonideThe risk or severity of adverse effects can be increased when Curcumin is combined with Amcinonide.Approved
AmikacinCurcumin may decrease the excretion rate of Amikacin which could result in a higher serum level.Approved, Investigational, Vet Approved
AmilorideCurcumin may decrease the antihypertensive activities of Amiloride.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Curcumin.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Curcumin.Approved
Aminosalicylic AcidThe risk or severity of adverse effects can be increased when Curcumin is combined with Aminosalicylic Acid.Approved
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Curcumin.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Curcumin.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Curcumin.Approved
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Curcumin.Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Curcumin.Approved, Illicit, Investigational
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Curcumin.Approved, Investigational
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Curcumin.Approved, Investigational
AnagrelideThe metabolism of Anagrelide can be decreased when combined with Curcumin.Approved
AncestimThe risk or severity of cytotoxicity can be increased when Ancestim is combined with Curcumin.Approved, Investigational, Withdrawn
AncrodCurcumin may increase the anticoagulant activities of Ancrod.Approved, Investigational
AndrographolideThe risk or severity of adverse effects can be increased when Andrographolide is combined with Curcumin.Investigational
AndrostenedioneThe risk or severity of adverse effects can be increased when Curcumin is combined with Androstenedione.Experimental, Illicit
AnecortaveThe risk or severity of adverse effects can be increased when Curcumin is combined with Anecortave.Investigational
anecortave acetateThe risk or severity of adverse effects can be increased when Curcumin is combined with anecortave acetate.Investigational
AnisodamineThe risk or severity of adverse effects can be increased when Curcumin is combined with Anisodamine.Investigational
AntipyrineThe risk or severity of adverse effects can be increased when Curcumin is combined with Antipyrine.Approved, Investigational
Antithrombin III humanCurcumin may increase the anticoagulant activities of Antithrombin III human.Approved
AntrafenineThe risk or severity of adverse effects can be increased when Curcumin is combined with Antrafenine.Approved
ApalutamideThe serum concentration of Apalutamide can be increased when it is combined with Curcumin.Approved, Investigational
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Curcumin.Approved
ApocyninThe risk or severity of adverse effects can be increased when Curcumin is combined with Apocynin.Investigational
ApramycinCurcumin may decrease the excretion rate of Apramycin which could result in a higher serum level.Experimental, Vet Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Curcumin.Approved, Investigational
AprepitantThe metabolism of Aprepitant can be decreased when combined with Curcumin.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Curcumin.Approved
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Curcumin.Experimental
ArbekacinCurcumin may decrease the excretion rate of Arbekacin which could result in a higher serum level.Approved, Investigational
ArdeparinCurcumin may increase the anticoagulant activities of Ardeparin.Approved, Investigational, Withdrawn
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Curcumin.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Curcumin.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Curcumin.Approved, Investigational
ArotinololCurcumin may decrease the antihypertensive activities of Arotinolol.Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Curcumin.Approved
AsenapineThe metabolism of Asenapine can be decreased when combined with Curcumin.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Curcumin.Approved, Withdrawn
AsunaprevirThe serum concentration of Asunaprevir can be increased when it is combined with Curcumin.Approved, Investigational, Withdrawn
AtamestaneThe risk or severity of adverse effects can be increased when Curcumin is combined with Atamestane.Investigational
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Curcumin.Approved, Investigational
AtenololCurcumin may decrease the antihypertensive activities of Atenolol.Approved
AtomoxetineThe metabolism of Atomoxetine can be decreased when combined with Curcumin.Approved
AtorvastatinThe risk or severity of adverse effects can be increased when Curcumin is combined with Atorvastatin.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Curcumin.Approved
AvatrombopagThe metabolism of Avatrombopag can be decreased when combined with Curcumin.Approved, Investigational
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Curcumin.Approved, Investigational
AzapropazoneThe risk or severity of adverse effects can be increased when Azapropazone is combined with Curcumin.Withdrawn
AzelastineThe metabolism of Azelastine can be decreased when combined with Curcumin.Approved
Azficel-TThe risk or severity of adverse effects can be increased when Curcumin is combined with Azficel-T.Approved, Investigational
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Azilsartan medoxomil is combined with Curcumin.Approved, Investigational
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Curcumin.Approved
AzosemideThe therapeutic efficacy of Azosemide can be decreased when used in combination with Curcumin.Investigational
BalsalazideThe risk or severity of adverse effects can be increased when Curcumin is combined with Balsalazide.Approved, Investigational
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Curcumin.Investigational
BaricitinibThe metabolism of Baricitinib can be decreased when combined with Curcumin.Approved, Investigational
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Curcumin.Approved
BecaplerminCurcumin may increase the anticoagulant activities of Becaplermin.Approved, Investigational
Beclomethasone dipropionateThe risk or severity of adverse effects can be increased when Curcumin is combined with Beclomethasone dipropionate.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Curcumin.Approved
BefunololCurcumin may decrease the antihypertensive activities of Befunolol.Experimental
BekanamycinCurcumin may decrease the excretion rate of Bekanamycin which could result in a higher serum level.Experimental
BenazeprilThe risk or severity of adverse effects can be increased when Curcumin is combined with Benazepril.Approved, Investigational
BendamustineThe metabolism of Bendamustine can be decreased when combined with Curcumin.Approved, Investigational
BendazacThe risk or severity of adverse effects can be increased when Curcumin is combined with Bendazac.Experimental
BendroflumethiazideThe therapeutic efficacy of Bendroflumethiazide can be decreased when used in combination with Curcumin.Approved
BenidipineThe metabolism of Benidipine can be decreased when combined with Curcumin.Approved, Investigational
BenorilateThe risk or severity of adverse effects can be increased when Curcumin is combined with Benorilate.Experimental
BenoxaprofenThe risk or severity of adverse effects can be increased when Benoxaprofen is combined with Curcumin.Withdrawn
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Curcumin.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Curcumin.Approved, Illicit
BenzthiazideThe therapeutic efficacy of Benzthiazide can be decreased when used in combination with Curcumin.Approved
BenzydamineThe risk or severity of adverse effects can be increased when Curcumin is combined with Benzydamine.Approved
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Curcumin.Approved
BepridilThe metabolism of Bepridil can be decreased when combined with Curcumin.Approved, Withdrawn
BeraprostThe therapeutic efficacy of Beraprost can be decreased when used in combination with Curcumin.Investigational
BetamethasoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Betamethasone.Approved, Vet Approved
BetaxololCurcumin may decrease the antihypertensive activities of Betaxolol.Approved, Investigational
BetrixabanThe risk or severity of bleeding can be increased when Betrixaban is combined with Curcumin.Approved, Investigational
BevacizumabBevacizumab may increase the cardiotoxic activities of Curcumin.Approved, Investigational
BevantololCurcumin may decrease the antihypertensive activities of Bevantolol.Approved
BevoniumThe risk or severity of adverse effects can be increased when Curcumin is combined with Bevonium.Experimental
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Curcumin.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Curcumin.Approved, Investigational
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Curcumin.Approved
BictegravirThe metabolism of Bictegravir can be decreased when combined with Curcumin.Approved, Investigational
BimatoprostThe therapeutic efficacy of Bimatoprost can be decreased when used in combination with Curcumin.Approved, Investigational
BioallethrinThe metabolism of Bioallethrin can be decreased when combined with Curcumin.Approved, Experimental
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Curcumin.Approved
BivalirudinCurcumin may increase the anticoagulant activities of Bivalirudin.Approved, Investigational
BlonanserinThe metabolism of Blonanserin can be decreased when combined with Curcumin.Approved, Investigational
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Curcumin.Approved, Withdrawn
BopindololCurcumin may decrease the antihypertensive activities of Bopindolol.Approved
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Curcumin.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Curcumin.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Curcumin.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Curcumin.Approved, Investigational
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Curcumin.Approved, Investigational
BrigatinibThe metabolism of Brigatinib can be decreased when combined with Curcumin.Approved, Investigational
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Curcumin.Approved
BrivaracetamThe metabolism of Brivaracetam can be decreased when combined with Curcumin.Approved, Investigational
BromazepamThe metabolism of Bromazepam can be decreased when combined with Curcumin.Approved, Illicit, Investigational
BromfenacThe risk or severity of adverse effects can be increased when Curcumin is combined with Bromfenac.Approved
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Curcumin.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Curcumin.Approved
BucillamineThe risk or severity of adverse effects can be increased when Curcumin is combined with Bucillamine.Investigational
BucindololCurcumin may decrease the antihypertensive activities of Bucindolol.Investigational
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Curcumin.Approved
BufexamacThe risk or severity of adverse effects can be increased when Curcumin is combined with Bufexamac.Approved, Experimental
BufuralolCurcumin may decrease the antihypertensive activities of Bufuralol.Experimental, Investigational
BumadizoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Bumadizone.Experimental
BumetanideThe therapeutic efficacy of Bumetanide can be decreased when used in combination with Curcumin.Approved
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Curcumin.Approved, Investigational
BupranololCurcumin may decrease the antihypertensive activities of Bupranolol.Approved
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Curcumin.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Curcumin.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Curcumin.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Curcumin.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Curcumin.Approved
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Curcumin.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Curcumin.Approved, Investigational
CaffeineThe metabolism of Caffeine can be decreased when combined with Curcumin.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Curcumin.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Curcumin.Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Curcumin.Experimental
Candesartan cilexetilThe metabolism of Candesartan cilexetil can be decreased when combined with Curcumin.Approved
CandoxatrilThe risk or severity of adverse effects can be increased when Curcumin is combined with Candoxatril.Experimental
CannabidiolThe metabolism of Cannabidiol can be decreased when combined with Curcumin.Approved, Investigational
CapsaicinThe risk or severity of adverse effects can be increased when Curcumin is combined with Capsaicin.Approved
CaptoprilThe risk or severity of adverse effects can be increased when Curcumin is combined with Captopril.Approved
CarbamazepineThe metabolism of Carbamazepine can be decreased when combined with Curcumin.Approved, Investigational
Carbaspirin calciumThe risk or severity of adverse effects can be increased when Curcumin is combined with Carbaspirin calcium.Experimental, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Curcumin.Approved
Carboprost TromethamineThe therapeutic efficacy of Carboprost Tromethamine can be decreased when used in combination with Curcumin.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Curcumin.Approved, Investigational
CarmustineThe metabolism of Carmustine can be decreased when combined with Curcumin.Approved, Investigational
CarprofenThe risk or severity of adverse effects can be increased when Curcumin is combined with Carprofen.Approved, Vet Approved, Withdrawn
CarteololCurcumin may decrease the antihypertensive activities of Carteolol.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Curcumin.Approved, Investigational
CastanospermineThe risk or severity of adverse effects can be increased when Castanospermine is combined with Curcumin.Experimental
CelecoxibThe risk or severity of adverse effects can be increased when Curcumin is combined with Celecoxib.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Curcumin.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Curcumin.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Curcumin.Approved, Withdrawn
CertoparinCurcumin may increase the anticoagulant activities of Certoparin.Approved, Investigational
CevimelineThe metabolism of Cevimeline can be decreased when combined with Curcumin.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Curcumin.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Curcumin.Approved, Illicit, Investigational
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
ChlorothiazideThe therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Curcumin.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Curcumin.Approved
ChlorphenesinThe risk or severity of adverse effects can be increased when Curcumin is combined with Chlorphenesin.Approved, Vet Approved, Withdrawn
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Curcumin.Approved, Investigational
ChlorthalidoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Curcumin.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Curcumin.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Curcumin.Approved, Nutraceutical
CholestyramineCholestyramine can cause a decrease in the absorption of Curcumin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Choline magnesium trisalicylateThe risk or severity of adverse effects can be increased when Curcumin is combined with Choline magnesium trisalicylate.Approved
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Curcumin.Approved, Investigational
CilazaprilThe risk or severity of adverse effects can be increased when Curcumin is combined with Cilazapril.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Curcumin.Approved, Investigational
CimicoxibThe risk or severity of adverse effects can be increased when Curcumin is combined with Cimicoxib.Investigational
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Curcumin.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Curcumin.Approved, Investigational
CinoxacinCurcumin may increase the neuroexcitatory activities of Cinoxacin.Approved, Investigational, Withdrawn
CiprofloxacinCurcumin may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
CisaprideThe metabolism of Cisapride can be decreased when combined with Curcumin.Approved, Investigational, Withdrawn
CisplatinThe risk or severity of adverse effects can be increased when Curcumin is combined with Cisplatin.Approved
CitalopramThe metabolism of Citalopram can be decreased when combined with Curcumin.Approved
Citric AcidCurcumin may increase the anticoagulant activities of Citric Acid.Approved, Nutraceutical, Vet Approved
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Curcumin.Approved
ClenbuterolThe metabolism of Clenbuterol can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Curcumin.Approved, Investigational
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Curcumin.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Curcumin.Approved, Illicit
ClobetasolThe risk or severity of adverse effects can be increased when Curcumin is combined with Clobetasol.Approved, Investigational
Clobetasol propionateThe risk or severity of adverse effects can be increased when Curcumin is combined with Clobetasol propionate.Approved
ClobetasoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Clobetasone.Approved
ClocortoloneThe risk or severity of adverse effects can be increased when Curcumin is combined with Clocortolone.Approved
Clodronic AcidThe risk or severity of adverse effects can be increased when Curcumin is combined with Clodronic Acid.Approved, Investigational, Vet Approved
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Curcumin.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Curcumin.Approved, Investigational
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Curcumin.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Curcumin.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Curcumin.Approved
ClonixinThe risk or severity of adverse effects can be increased when Clonixin is combined with Curcumin.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Curcumin.Approved
CloprostenolThe therapeutic efficacy of Cloprostenol can be decreased when used in combination with Curcumin.Vet Approved
CloranololCurcumin may decrease the antihypertensive activities of Cloranolol.Experimental
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Curcumin.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Curcumin.Approved, Illicit
ClozapineThe metabolism of Clozapine can be decreased when combined with Curcumin.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Curcumin.Approved, Investigational
CocaineThe metabolism of Cocaine can be decreased when combined with Curcumin.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Curcumin.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Curcumin.Approved
ColesevelamColesevelam can cause a decrease in the absorption of Curcumin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Curcumin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Curcumin.Approved, Investigational
Conjugated estrogensThe metabolism of Conjugated estrogens can be decreased when combined with Curcumin.Approved
CopanlisibThe metabolism of Copanlisib can be decreased when combined with Curcumin.Approved, Investigational
Cortexolone 17α-propionateThe risk or severity of adverse effects can be increased when Curcumin is combined with Cortexolone 17α-propionate.Investigational
CorticosteroneThe risk or severity of adverse effects can be increased when Curcumin is combined with Corticosterone.Experimental
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Curcumin.Approved, Investigational
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Curcumin.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Curcumin.Approved
CyclopenthiazideThe therapeutic efficacy of Cyclopenthiazide can be decreased when used in combination with Curcumin.Experimental
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Curcumin.Approved, Investigational
CyclosporineCurcumin may increase the nephrotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
CymarinCymarin may decrease the cardiotoxic activities of Curcumin.Experimental
CytarabineThe metabolism of Cytarabine can be decreased when combined with Curcumin.Approved, Investigational
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Curcumin.Approved
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Curcumin.Approved, Investigational
DacarbazineThe metabolism of Dacarbazine can be decreased when combined with Curcumin.Approved, Investigational
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Curcumin.Approved, Investigational
DalteparinCurcumin may increase the anticoagulant activities of Dalteparin.Approved
DanaparoidCurcumin may increase the anticoagulant activities of Danaparoid.Approved, Withdrawn
DantroleneThe metabolism of Dantrolene can be decreased when combined with Curcumin.Approved, Investigational
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Curcumin.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Curcumin.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Curcumin.Approved, Investigational
DarexabanCurcumin may increase the anticoagulant activities of Darexaban.Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Curcumin.Approved, Investigational
DarunavirThe metabolism of Darunavir can be decreased when combined with Curcumin.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Curcumin.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Curcumin.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Curcumin.Approved
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Curcumin.Approved, Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Curcumin is combined with Deferasirox.Approved, Investigational
DeflazacortThe metabolism of Deflazacort can be decreased when combined with Curcumin.Approved, Investigational
DelamanidCurcumin may increase the QTc-prolonging activities of Delamanid.Approved, Investigational
DelaprilThe risk or severity of adverse effects can be increased when Curcumin is combined with Delapril.Investigational
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Curcumin.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Curcumin.Approved, Investigational
DesirudinCurcumin may increase the anticoagulant activities of Desirudin.Approved
DeslanosideDeslanoside may decrease the cardiotoxic activities of Curcumin.Approved
DesmopressinThe risk or severity of adverse effects can be increased when Curcumin is combined with Desmopressin.Approved
DesonideThe risk or severity of adverse effects can be increased when Curcumin is combined with Desonide.Approved, Investigational
DesoximetasoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Desoximetasone.Approved
Desoxycorticosterone acetateThe risk or severity of adverse effects can be increased when Curcumin is combined with Desoxycorticosterone acetate.Approved
Desoxycorticosterone PivalateThe risk or severity of adverse effects can be increased when Curcumin is combined with Desoxycorticosterone Pivalate.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Curcumin.Approved, Investigational
DeutetrabenazineThe metabolism of Deutetrabenazine can be decreased when combined with Curcumin.Approved, Investigational
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe risk or severity of adverse effects can be increased when Curcumin is combined with Dexamethasone isonicotinate.Vet Approved
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be decreased when combined with Curcumin.Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Curcumin.Approved, Illicit, Investigational, Withdrawn
DexibuprofenThe risk or severity of adverse effects can be increased when Curcumin is combined with Dexibuprofen.Approved, Investigational
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Curcumin.Approved, Investigational
DexlansoprazoleThe metabolism of Dexlansoprazole can be decreased when combined with Curcumin.Approved, Investigational
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Curcumin.Approved, Investigational
DextranCurcumin may increase the anticoagulant activities of Dextran.Approved, Investigational, Vet Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Curcumin.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Curcumin.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Curcumin.Approved, Illicit, Investigational, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Curcumin.Approved, Illicit, Investigational, Vet Approved
DibekacinCurcumin may decrease the excretion rate of Dibekacin which could result in a higher serum level.Experimental
Dibotermin alfaThe risk or severity of adverse effects can be increased when Curcumin is combined with Dibotermin alfa.Approved, Investigational
DiclofenacThe risk or severity of adverse effects can be increased when Diclofenac is combined with Curcumin.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Curcumin.Approved
DienogestThe serum concentration of Dienogest can be increased when it is combined with Curcumin.Approved
DifenpiramideThe risk or severity of adverse effects can be increased when Curcumin is combined with Difenpiramide.Experimental
DiflorasoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Diflorasone.Approved
DiflunisalThe risk or severity of adverse effects can be increased when Curcumin is combined with Diflunisal.Approved, Investigational
DifluocortoloneThe risk or severity of adverse effects can be increased when Curcumin is combined with Difluocortolone.Approved, Investigational, Withdrawn
DifluprednateThe risk or severity of adverse effects can be increased when Curcumin is combined with Difluprednate.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Curcumin.Approved, Investigational
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Curcumin.Approved
Digoxin Immune Fab (Ovine)Digoxin Immune Fab (Ovine) may decrease the cardiotoxic activities of Curcumin.Approved
Dihydro-alpha-ergocryptineThe metabolism of Dihydro-alpha-ergocryptine can be decreased when combined with Curcumin.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Curcumin.Approved, Illicit
DihydroergocornineThe risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Curcumin.Approved
DihydroergocristineThe risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Curcumin.Approved, Experimental
DihydroergocryptineThe risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Curcumin.Experimental
DihydroergotamineThe risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Curcumin.Approved, Investigational
DihydrostreptomycinCurcumin may decrease the excretion rate of Dihydrostreptomycin which could result in a higher serum level.Investigational, Vet Approved
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Curcumin.Approved, Investigational
DinoprostThe therapeutic efficacy of Dinoprost can be decreased when used in combination with Curcumin.Investigational
Dinoprost TromethamineThe therapeutic efficacy of Dinoprost Tromethamine can be decreased when used in combination with Curcumin.Approved, Vet Approved
DinoprostoneThe therapeutic efficacy of Dinoprostone can be decreased when used in combination with Curcumin.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Curcumin.Approved, Investigational
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Curcumin.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Curcumin.Approved
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Curcumin.Approved, Investigational
DoconexentThe metabolism of Doconexent can be decreased when combined with Curcumin.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Curcumin.Approved, Investigational
DolasetronThe metabolism of Dolasetron can be decreased when combined with Curcumin.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Curcumin.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Curcumin.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Curcumin.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Curcumin.Approved
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Curcumin.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Curcumin.Approved, Investigational
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Curcumin.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Curcumin.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Curcumin.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Curcumin.Approved
DrospirenoneCurcumin may increase the hyperkalemic activities of Drospirenone.Approved
DroxicamThe risk or severity of adverse effects can be increased when Curcumin is combined with Droxicam.Withdrawn
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Curcumin.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Curcumin.Approved, Investigational
DuvelisibThe risk or severity of adverse effects can be increased when Curcumin is combined with Duvelisib.Investigational
E-6201The risk or severity of adverse effects can be increased when Curcumin is combined with E-6201.Investigational
Edetic AcidCurcumin may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Curcumin.Approved
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Curcumin.Approved, Investigational
ElbasvirThe metabolism of Elbasvir can be decreased when combined with Curcumin.Approved
EletriptanThe metabolism of Eletriptan can be decreased when combined with Curcumin.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Curcumin.Approved
EltrombopagThe metabolism of Eltrombopag can be decreased when combined with Curcumin.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Curcumin.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Curcumin.Approved, Vet Approved
EnalaprilatThe risk or severity of adverse effects can be increased when Curcumin is combined with Enalaprilat.Approved
EnasidenibThe metabolism of Enasidenib can be decreased when combined with Curcumin.Approved, Investigational
EncainideThe metabolism of Encainide can be decreased when combined with Curcumin.Approved, Investigational, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Curcumin.Investigational
EnoxacinCurcumin may increase the neuroexcitatory activities of Enoxacin.Approved, Investigational
EnoxaparinCurcumin may increase the anticoagulant activities of Enoxaparin.Approved
EnprostilThe therapeutic efficacy of Enprostil can be decreased when used in combination with Curcumin.Experimental
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Curcumin.Approved
EpanololCurcumin may decrease the antihypertensive activities of Epanolol.Experimental
EpinastineThe metabolism of Epinastine can be decreased when combined with Curcumin.Approved, Investigational
EpirizoleThe risk or severity of adverse effects can be increased when Epirizole is combined with Curcumin.Approved
EpitizideThe therapeutic efficacy of Epitizide can be decreased when used in combination with Curcumin.Experimental
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Curcumin.Approved
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Curcumin.Approved
EprosartanThe risk or severity of adverse effects can be increased when Eprosartan is combined with Curcumin.Approved
EquileninThe risk or severity of adverse effects can be increased when Curcumin is combined with Equilenin.Experimental
EquilinThe risk or severity of adverse effects can be increased when Curcumin is combined with Equilin.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Curcumin.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Curcumin.Approved
ErgonovineThe risk or severity of adverse effects can be increased when Ergonovine is combined with Curcumin.Approved
ErgotamineThe risk or severity of adverse effects can be increased when Ergotamine is combined with Curcumin.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Curcumin.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
EsatenololCurcumin may decrease the antihypertensive activities of Esatenolol.Experimental
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Curcumin.Approved, Investigational
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Curcumin.Investigational
EsmololCurcumin may decrease the antihypertensive activities of Esmolol.Approved
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Curcumin.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Curcumin.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
Estradiol acetateThe metabolism of Estradiol acetate can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
Estradiol benzoateThe metabolism of Estradiol benzoate can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
Estradiol cypionateThe metabolism of Estradiol cypionate can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
Estradiol dienanthateThe metabolism of Estradiol dienanthate can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
Estradiol valerateThe metabolism of Estradiol valerate can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Curcumin.Approved, Investigational
Estrogens, esterifiedThe metabolism of Estrogens, esterified can be decreased when combined with Curcumin.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Curcumin.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Curcumin.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Curcumin.Approved, Investigational
Etacrynic acidThe therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Curcumin.Approved, Investigational
EtanerceptThe risk or severity of adverse effects can be increased when Curcumin is combined with Etanercept.Approved, Investigational
EthanolThe metabolism of Ethanol can be decreased when combined with Curcumin.Approved
EthenzamideThe risk or severity of adverse effects can be increased when Curcumin is combined with Ethenzamide.Experimental
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Curcumin.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Curcumin.Approved
Ethyl biscoumacetateCurcumin may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Curcumin.Approved, Illicit
Etidronic acidThe risk or severity of adverse effects can be increased when Curcumin is combined with Etidronic acid.Approved
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Curcumin.Approved
EtodolacThe risk or severity of adverse effects can be increased when Curcumin is combined with Etodolac.Approved, Investigational, Vet Approved
EtofenamateThe risk or severity of adverse effects can be increased when Etofenamate is combined with Curcumin.Approved, Investigational
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Curcumin.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Curcumin.Approved
EtoricoxibThe risk or severity of adverse effects can be increased when Curcumin is combined with Etoricoxib.Approved, Investigational
EtravirineThe metabolism of Etravirine can be decreased when combined with Curcumin.Approved
Evening primrose oilThe risk or severity of adverse effects can be increased when Evening primrose oil is combined with Curcumin.Investigational, Nutraceutical
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Curcumin.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Curcumin.Approved, Investigational
ExisulindThe risk or severity of adverse effects can be increased when Exisulind is combined with Curcumin.Investigational
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Curcumin.Approved, Investigational
FelbamateThe metabolism of Felbamate can be decreased when combined with Curcumin.Approved
FelbinacThe risk or severity of adverse effects can be increased when Felbinac is combined with Curcumin.Experimental
FelodipineThe metabolism of Felodipine can be decreased when combined with Curcumin.Approved, Investigational
FenbufenThe risk or severity of adverse effects can be increased when Fenbufen is combined with Curcumin.Approved
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Curcumin.Approved
FenoprofenThe risk or severity of adverse effects can be increased when Curcumin is combined with Fenoprofen.Approved
FenprostaleneThe therapeutic efficacy of Fenprostalene can be decreased when used in combination with Curcumin.Vet Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Curcumin.Approved, Illicit, Investigational, Vet Approved
FentiazacThe risk or severity of adverse effects can be increased when Curcumin is combined with Fentiazac.Experimental
FeprazoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Feprazone.Experimental
Ferulic acidCurcumin may increase the anticoagulant activities of Ferulic acid.Experimental
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Curcumin.Approved
FimasartanThe risk or severity of adverse effects can be increased when Fimasartan is combined with Curcumin.Approved, Investigational
FinasterideThe metabolism of Finasteride can be decreased when combined with Curcumin.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Curcumin.Approved, Investigational
Fish oilThe risk or severity of adverse effects can be increased when Curcumin is combined with Fish oil.Approved, Nutraceutical
FlecainideThe metabolism of Flecainide can be decreased when combined with Curcumin.Approved, Withdrawn
FleroxacinCurcumin may increase the neuroexcitatory activities of Fleroxacin.Approved
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Curcumin.Approved, Investigational
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Curcumin.Approved, Withdrawn
FluasteroneThe risk or severity of adverse effects can be increased when Curcumin is combined with Fluasterone.Investigational
FludrocortisoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Fludrocortisone.Approved, Investigational
FluindioneCurcumin may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlumequineCurcumin may increase the neuroexcitatory activities of Flumequine.Withdrawn
FlumethasoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Flumethasone.Approved, Vet Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Curcumin.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Curcumin.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Curcumin.Approved, Illicit
FlunixinThe risk or severity of adverse effects can be increased when Flunixin is combined with Curcumin.Vet Approved
FlunoxaprofenThe risk or severity of adverse effects can be increased when Curcumin is combined with Flunoxaprofen.Experimental
Fluocinolone AcetonideThe risk or severity of adverse effects can be increased when Curcumin is combined with Fluocinolone Acetonide.Approved, Investigational, Vet Approved
FluocinonideThe risk or severity of adverse effects can be increased when Curcumin is combined with Fluocinonide.Approved, Investigational
FluocortoloneThe risk or severity of adverse effects can be increased when Curcumin is combined with Fluocortolone.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Curcumin.Approved, Investigational
FluorouracilThe metabolism of Fluorouracil can be decreased when combined with Curcumin.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Curcumin.Approved, Vet Approved
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Curcumin.Approved
FluprednideneThe risk or severity of adverse effects can be increased when Curcumin is combined with Fluprednidene.Approved, Withdrawn
FluprednisoloneThe risk or severity of adverse effects can be increased when Curcumin is combined with Fluprednisolone.Approved
FluprostenolThe therapeutic efficacy of Fluprostenol can be decreased when used in combination with Curcumin.Vet Approved
FlurandrenolideThe risk or severity of adverse effects can be increased when Curcumin is combined with Flurandrenolide.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Curcumin.Approved, Illicit, Investigational
FlurbiprofenThe risk or severity of adverse effects can be increased when Curcumin is combined with Flurbiprofen.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Curcumin.Approved, Investigational
FluticasoneThe serum concentration of Fluticasone can be increased when it is combined with Curcumin.Approved, Experimental, Investigational
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Curcumin.Approved
Fluticasone propionateThe serum concentration of Fluticasone propionate can be increased when it is combined with Curcumin.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Curcumin.Approved
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Curcumin.Approved, Investigational
Folic AcidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Curcumin.Approved, Nutraceutical, Vet Approved
FondaparinuxCurcumin may increase the anticoagulant activities of Fondaparinux sodium.Approved, Investigational
ForasartanThe risk or severity of adverse effects can be increased when Forasartan is combined with Curcumin.Experimental
FormestaneThe risk or severity of adverse effects can be increased when Curcumin is combined with Formestane.Approved, Investigational, Withdrawn
FormoterolThe metabolism of Formoterol can be decreased when combined with Curcumin.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Curcumin.Approved
FosinoprilThe risk or severity of adverse effects can be increased when Curcumin is combined with Fosinopril.Approved
FosnetupitantThe metabolism of Fosnetupitant can be decreased when combined with Curcumin.Approved
FosphenytoinThe metabolism of Fosphenytoin can be decreased when combined with Curcumin.Approved, Investigational
FostamatinibThe metabolism of Fostamatinib can be decreased when combined with Curcumin.Approved, Investigational
FramycetinCurcumin may decrease the excretion rate of Framycetin which could result in a higher serum level.Approved
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Curcumin.Approved, Investigational
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Curcumin.Approved, Investigational
FurosemideThe therapeutic efficacy of Furosemide can be decreased when used in combination with Curcumin.Approved, Vet Approved
GabexateCurcumin may increase the anticoagulant activities of Gabexate.Investigational
GalantamineThe metabolism of Galantamine can be decreased when combined with Curcumin.Approved
GarenoxacinCurcumin may increase the neuroexcitatory activities of Garenoxacin.Investigational
GatifloxacinCurcumin may increase the neuroexcitatory activities of Gatifloxacin.Approved, Investigational
GavestinelThe metabolism of Gavestinel can be decreased when combined with Curcumin.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Curcumin.Approved, Investigational
GemeprostThe therapeutic efficacy of Gemeprost can be decreased when used in combination with Curcumin.Approved, Withdrawn
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Curcumin.Approved
GemifloxacinCurcumin may increase the neuroexcitatory activities of Gemifloxacin.Approved, Investigational
GeneticinCurcumin may decrease the excretion rate of Geneticin which could result in a higher serum level.Experimental
GenisteinThe metabolism of Genistein can be decreased when combined with Curcumin.Investigational
GentamicinCurcumin may decrease the excretion rate of Gentamicin which could result in a higher serum level.Approved, Vet Approved
GENTAMICIN C1ACurcumin may decrease the excretion rate of GENTAMICIN C1A which could result in a higher serum level.Experimental
GinsengThe risk or severity of adverse effects can be increased when Curcumin is combined with Ginseng.Approved, Investigational, Nutraceutical
GitoformateGitoformate may decrease the cardiotoxic activities of Curcumin.Experimental
GliclazideThe metabolism of Gliclazide can be decreased when combined with Curcumin.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Curcumin.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Curcumin.Approved, Investigational
GlyburideThe metabolism of Glyburide can be decreased when combined with Curcumin.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Curcumin.Approved, Investigational
GrazoprevirThe metabolism of Grazoprevir can be decreased when combined with Curcumin.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Curcumin.Approved, Investigational, Withdrawn
GuacetisalThe risk or severity of adverse effects can be increased when Curcumin is combined with Guacetisal.Experimental
GuanabenzThe metabolism of Guanabenz can be decreased when combined with Curcumin.Approved, Investigational
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Curcumin.Approved, Investigational
HalcinonideThe risk or severity of adverse effects can be increased when Curcumin is combined with Halcinonide.Approved, Investigational, Withdrawn
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Curcumin.Approved
HaloperidolThe risk or severity of adverse effects can be increased when Curcumin is combined with Haloperidol.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Curcumin.Approved, Vet Approved
HE3286The risk or severity of adverse effects can be increased when Curcumin is combined with HE3286.Investigational
HeparinCurcumin may increase the anticoagulant activities of Heparin.Approved, Investigational
HesperetinThe metabolism of Hesperetin can be decreased when combined with Curcumin.Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Curcumin.Approved
HigenamineThe risk or severity of adverse effects can be increased when Curcumin is combined with Higenamine.Investigational
HistamineThe metabolism of Histamine can be decreased when combined with Curcumin.Approved, Investigational
HydralazineCurcumin may decrease the antihypertensive activities of Hydralazine.Approved
HydrochlorothiazideThe therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Curcumin.Approved, Vet Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Curcumin.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Curcumin.Approved, Vet Approved
HydroflumethiazideThe therapeutic efficacy of Hydroflumethiazide can be decreased when used in combination with Curcumin.Approved, Investigational
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Curcumin.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Curcumin.Approved, Investigational
Hygromycin BCurcumin may decrease the excretion rate of Hygromycin B which could result in a higher serum level.Vet Approved
IbandronateThe risk or severity of adverse effects can be increased when Curcumin is combined with Ibandronate.Approved, Investigational
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Curcumin.Approved
IbuprofenThe risk or severity of adverse effects can be increased when Curcumin is combined with Ibuprofen.Approved
IbuproxamThe risk or severity of adverse effects can be increased when Ibuproxam is combined with Curcumin.Withdrawn
IcatibantThe risk or severity of adverse effects can be increased when Icatibant is combined with Curcumin.Approved, Investigational
IcosapentThe risk or severity of adverse effects can be increased when Curcumin is combined with Icosapent.Approved, Nutraceutical
IcotinibThe metabolism of Icotinib can be decreased when combined with Curcumin.Approved, Investigational
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Curcumin.Approved
IdelalisibThe serum concentration of Idelalisib can be increased when it is combined with Curcumin.Approved
IdraparinuxCurcumin may increase the anticoagulant activities of Idraparinux.Investigational
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Curcumin resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Curcumin.Approved
IloprostThe therapeutic efficacy of Iloprost can be decreased when used in combination with Curcumin.Approved, Investigational
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Curcumin.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Curcumin.Approved, Investigational
ImidaprilThe risk or severity of adverse effects can be increased when Curcumin is combined with Imidapril.Investigational
Imidazole salicylateThe risk or severity of adverse effects can be increased when Curcumin is combined with Imidazole salicylate.Experimental
ImipramineThe metabolism of Imipramine can be decreased when combined with Curcumin.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Curcumin.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Curcumin.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Curcumin.Approved
IndenololCurcumin may decrease the antihypertensive activities of Indenolol.Withdrawn
IndinavirThe metabolism of Indinavir can be decreased when combined with Curcumin.Approved
IndisulamThe metabolism of Indisulam can be decreased when combined with Curcumin.Investigational
IndobufenThe risk or severity of adverse effects can be increased when Curcumin is combined with Indobufen.Investigational
IndomethacinThe risk or severity of adverse effects can be increased when Curcumin is combined with Indomethacin.Approved, Investigational
IndoprofenThe risk or severity of adverse effects can be increased when Indoprofen is combined with Curcumin.Withdrawn
IpecacThe metabolism of Ipecac can be decreased when combined with Curcumin.Approved, Withdrawn
IpratropiumThe metabolism of Ipratropium bromide can be decreased when combined with Curcumin.Approved
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Curcumin.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Curcumin.Approved, Investigational
IsavuconazoleThe serum concentration of Isavuconazole can be increased when it is combined with Curcumin.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Curcumin.Approved, Investigational
IsepamicinCurcumin may decrease the excretion rate of Isepamicin which could result in a higher serum level.Experimental
IsofluraneThe metabolism of Isoflurane can be decreased when combined with Curcumin.Approved, Vet Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Curcumin.Approved, Investigational
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Curcumin.Approved
IsoxicamThe risk or severity of adverse effects can be increased when Isoxicam is combined with Curcumin.Withdrawn
IsradipineThe metabolism of Isradipine can be decreased when combined with Curcumin.Approved, Investigational
IstaroximeThe risk or severity of adverse effects can be increased when Curcumin is combined with Istaroxime.Investigational
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Curcumin.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Curcumin.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Curcumin.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Curcumin.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Curcumin.Approved, Investigational
KanamycinCurcumin may decrease the excretion rate of Kanamycin which could result in a higher serum level.Approved, Investigational, Vet Approved
KebuzoneThe risk or severity of adverse effects can be increased when Kebuzone is combined with Curcumin.Experimental
KetamineThe metabolism of Ketamine can be decreased when combined with Curcumin.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Curcumin.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Curcumin.Approved, Investigational
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Curcumin.Approved, Investigational
KetoprofenThe risk or severity of adverse effects can be increased when Curcumin is combined with Ketoprofen.Approved, Vet Approved
KetorolacThe risk or severity of adverse effects can be increased when Ketorolac is combined with Curcumin.Approved
LabetalolCurcumin may decrease the antihypertensive activities of Labetalol.Approved
LacidipineThe serum concentration of Lacidipine can be increased when it is combined with Curcumin.Approved, Investigational
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Curcumin.Approved
Lanatoside CLanatoside C may decrease the cardiotoxic activities of Curcumin.Experimental
LandiololCurcumin may decrease the antihypertensive activities of Landiolol.Investigational
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Curcumin.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Curcumin.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Curcumin.Investigational
LatanoprostThe therapeutic efficacy of Latanoprost can be decreased when used in combination with Curcumin.Approved, Investigational
Latanoprostene BunodThe therapeutic efficacy of Latanoprostene Bunod can be decreased when used in combination with Curcumin.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Curcumin.Approved
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Curcumin.Approved, Investigational
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Curcumin.Approved, Investigational
LepirudinCurcumin may increase the anticoagulant activities of Lepirudin.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Curcumin.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Curcumin.Approved, Investigational
LetaxabanCurcumin may increase the anticoagulant activities of Letaxaban.Investigational
LetermovirThe metabolism of Letermovir can be decreased when combined with Curcumin.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Curcumin.Approved, Investigational
LevobetaxololCurcumin may decrease the antihypertensive activities of Levobetaxolol.Approved, Investigational
LevobunololCurcumin may decrease the antihypertensive activities of Levobunolol.Approved
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Curcumin.Approved, Investigational
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Curcumin.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Curcumin.Approved
LevofloxacinCurcumin may increase the neuroexcitatory activities of Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Curcumin.Approved, Investigational
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Curcumin.Approved, Investigational
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Curcumin.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Curcumin.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Curcumin.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Curcumin.Approved, Vet Approved
LimaprostThe therapeutic efficacy of Limaprost can be decreased when used in combination with Curcumin.Approved, Investigational
LisinoprilThe risk or severity of adverse effects can be increased when Curcumin is combined with Lisinopril.Approved, Investigational
LisofyllineThe risk or severity of adverse effects can be increased when Curcumin is combined with Lisofylline.Investigational
LisurideThe risk or severity of adverse effects can be increased when Lisuride is combined with Curcumin.Approved, Investigational
Lithium cationThe serum concentration of Lithium can be increased when it is combined with Curcumin.Experimental
LofexidineThe metabolism of Lofexidine can be decreased when combined with Curcumin.Approved, Investigational
LomefloxacinCurcumin may increase the neuroexcitatory activities of Lomefloxacin.Approved, Investigational
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Curcumin.Approved, Investigational
LomustineThe metabolism of Lomustine can be decreased when combined with Curcumin.Approved, Investigational
LonazolacThe risk or severity of adverse effects can be increased when Curcumin is combined with Lonazolac.Experimental
LoperamideThe metabolism of Loperamide can be decreased when combined with Curcumin.Approved
LopinavirThe metabolism of Lopinavir can be decreased when combined with Curcumin.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Curcumin.Approved, Investigational
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Curcumin.Approved
LornoxicamThe risk or severity of adverse effects can be increased when Curcumin is combined with Lornoxicam.Approved, Investigational
LorpiprazoleThe metabolism of Lorpiprazole can be decreased when combined with Curcumin.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Curcumin.Approved
LoteprednolThe risk or severity of adverse effects can be increased when Curcumin is combined with Loteprednol.Approved
LoxoprofenThe risk or severity of adverse effects can be increased when Loxoprofen is combined with Curcumin.Approved, Investigational
LubiprostoneThe therapeutic efficacy of Lubiprostone can be decreased when used in combination with Curcumin.Approved, Investigational
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Curcumin.Approved
LumiracoxibThe risk or severity of adverse effects can be increased when Curcumin is combined with Lumiracoxib.Approved, Investigational
LuprostiolThe therapeutic efficacy of Luprostiol can be decreased when used in combination with Curcumin.Vet Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Curcumin.Approved, Investigational
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Curcumin.Illicit, Investigational, Withdrawn
MacimorelinThe metabolism of Macimorelin can be decreased when combined with Curcumin.Approved, Investigational
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Curcumin.Approved
Magnesium salicylateThe risk or severity of adverse effects can be increased when Curcumin is combined with Magnesium salicylate.Approved
MalathionThe metabolism of Malathion can be decreased when combined with Curcumin.Approved, Investigational
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Curcumin.Approved, Investigational
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Curcumin.Approved, Investigational
MasoprocolThe risk or severity of adverse effects can be increased when Masoprocol is combined with Curcumin.Approved, Investigational
ME-609The risk or severity of adverse effects can be increased when Curcumin is combined with ME-609.Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Curcumin.Approved, Vet Approved
Meclofenamic acidThe risk or severity of adverse effects can be increased when Curcumin is combined with Meclofenamic acid.Approved, Vet Approved
Medical CannabisThe metabolism of Medical Cannabis can be decreased when combined with Curcumin.Experimental, Investigational
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Curcumin.Approved, Investigational
MedrysoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Medrysone.Approved
Mefenamic acidThe risk or severity of adverse effects can be increased when Curcumin is combined with Mefenamic acid.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Curcumin.Approved, Investigational
MelagatranCurcumin may increase the anticoagulant activities of Melagatran.Experimental
MelatoninThe metabolism of Melatonin can be decreased when combined with Curcumin.Approved, Nutraceutical, Vet Approved
MelengestrolThe risk or severity of adverse effects can be increased when Curcumin is combined with Melengestrol.Vet Approved
MeloxicamThe risk or severity of adverse effects can be increased when Curcumin is combined with Meloxicam.Approved, Vet Approved
MenadioneThe metabolism of Menadione can be decreased when combined with Curcumin.Approved, Nutraceutical
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Curcumin.Investigational, Withdrawn
MepindololCurcumin may decrease the antihypertensive activities of Mepindolol.Experimental
MequitazineThe metabolism of Mequitazine can be decreased when combined with Curcumin.Approved
MesalazineThe risk or severity of adverse effects can be increased when Curcumin is combined with Mesalazine.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Curcumin.Approved, Investigational
MestranolThe metabolism of Mestranol can be decreased when combined with Curcumin.Approved
MetamizoleThe risk or severity of adverse effects can be increased when Metamizole is combined with Curcumin.Approved, Investigational, Withdrawn
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Curcumin.Experimental
MethadoneThe metabolism of Methadone can be decreased when combined with Curcumin.Approved
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Curcumin.Approved, Illicit
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Curcumin.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Curcumin.Approved
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Curcumin.Approved, Investigational
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Curcumin.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
MethyclothiazideThe therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Curcumin.Approved
MethylergometrineThe risk or severity of adverse effects can be increased when Methylergometrine is combined with Curcumin.Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Curcumin.Approved, Investigational
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Curcumin.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Curcumin.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Curcumin.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Curcumin.Approved, Illicit, Withdrawn
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Curcumin.Approved
MetildigoxinMetildigoxin may decrease the cardiotoxic activities of Curcumin.Experimental
MetipranololCurcumin may decrease the antihypertensive activities of Metipranolol.Approved
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Curcumin.Approved, Investigational
MetolazoneThe therapeutic efficacy of Metolazone can be decreased when used in combination with Curcumin.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Curcumin.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Curcumin.Approved
MevastatinThe serum concentration of Mevastatin can be increased when it is combined with Curcumin.Experimental
MexiletineThe metabolism of Mexiletine can be decreased when combined with Curcumin.Approved, Investigational
MianserinThe metabolism of Mianserin can be decreased when combined with Curcumin.Approved, Investigational
MibefradilThe metabolism of Mibefradil can be decreased when combined with Curcumin.Investigational, Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
MicronomicinCurcumin may decrease the excretion rate of Micronomicin which could result in a higher serum level.Experimental
MidazolamThe metabolism of Midazolam can be decreased when combined with Curcumin.Approved, Illicit
MidecamycinThe metabolism of Midecamycin can be decreased when combined with Curcumin.Approved
MidostaurinThe metabolism of Midostaurin can be decreased when combined with Curcumin.Approved, Investigational
MifamurtideThe therapeutic efficacy of Mifamurtide can be decreased when used in combination with Curcumin.Approved, Experimental
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Curcumin.Approved, Investigational
MinaprineThe metabolism of Minaprine can be decreased when combined with Curcumin.Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Curcumin.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Curcumin.Approved
MisoprostolThe therapeutic efficacy of Misoprostol can be decreased when used in combination with Curcumin.Approved
MizoribineThe risk or severity of adverse effects can be increased when Curcumin is combined with Mizoribine.Investigational
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Curcumin.Approved, Investigational
ModafinilThe metabolism of Modafinil can be decreased when combined with Curcumin.Approved, Investigational
MoexiprilThe risk or severity of adverse effects can be increased when Curcumin is combined with Moexipril.Approved
MofebutazoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Mofebutazone.Experimental
MometasoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Mometasone.Approved, Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Curcumin.Approved
MorniflumateThe risk or severity of adverse effects can be increased when Morniflumate is combined with Curcumin.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Curcumin.Approved, Investigational
MoxifloxacinCurcumin may increase the neuroexcitatory activities of Moxifloxacin.Approved, Investigational
MuraglitazarThe metabolism of Muraglitazar can be decreased when combined with Curcumin.Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Curcumin.Approved, Investigational
Mycophenolic acidThe risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Curcumin.Approved
NabiximolsThe metabolism of Nabiximols can be decreased when combined with Curcumin.Approved, Investigational
NabumetoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Nabumetone.Approved
NadololCurcumin may decrease the antihypertensive activities of Nadolol.Approved
NadroparinCurcumin may increase the anticoagulant activities of Nadroparin.Approved, Investigational
NafamostatCurcumin may increase the anticoagulant activities of Nafamostat.Approved, Investigational
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Curcumin.Approved
Nalidixic AcidCurcumin may increase the neuroexcitatory activities of Nalidixic Acid.Approved, Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Curcumin.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Curcumin.Approved, Vet Approved
NaproxenThe risk or severity of adverse effects can be increased when Curcumin is combined with Naproxen.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Curcumin.Approved, Investigational
NCX 1022The risk or severity of adverse effects can be increased when Curcumin is combined with NCX 1022.Investigational
NeamineCurcumin may decrease the excretion rate of Neamine which could result in a higher serum level.Experimental
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Curcumin.Approved, Investigational
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Curcumin.Approved, Withdrawn
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Curcumin.Approved
NemonoxacinCurcumin may increase the neuroexcitatory activities of Nemonoxacin.Investigational
NeomycinCurcumin may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
NepafenacThe risk or severity of adverse effects can be increased when Curcumin is combined with Nepafenac.Approved, Investigational
NeratinibThe metabolism of Neratinib can be decreased when combined with Curcumin.Approved, Investigational
NetilmicinCurcumin may decrease the excretion rate of Netilmicin which could result in a higher serum level.Approved, Investigational
NetupitantThe metabolism of Netupitant can be decreased when combined with Curcumin.Approved, Investigational
NevirapineThe metabolism of Nevirapine can be decreased when combined with Curcumin.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Curcumin.Approved, Investigational
NicergolineThe risk or severity of adverse effects can be increased when Nicergoline is combined with Curcumin.Approved, Investigational
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Curcumin.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Curcumin.Approved
NifenazoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Nifenazone.Experimental
Niflumic AcidThe risk or severity of adverse effects can be increased when Curcumin is combined with Niflumic Acid.Approved
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Curcumin.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Curcumin.Approved, Investigational
NimesulideThe risk or severity of adverse effects can be increased when Curcumin is combined with Nimesulide.Approved, Investigational, Withdrawn
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Curcumin.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Curcumin.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Curcumin.Approved
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Curcumin.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Curcumin.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Curcumin.Approved, Investigational
Nitric OxideThe metabolism of Nitric Oxide can be decreased when combined with Curcumin.Approved
NitroaspirinThe risk or severity of adverse effects can be increased when Curcumin is combined with Nitroaspirin.Investigational
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Curcumin.Approved
NorfloxacinCurcumin may increase the neuroexcitatory activities of Norfloxacin.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Curcumin.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Curcumin.Approved
OdanacatibThe metabolism of Odanacatib can be decreased when combined with Curcumin.Investigational
OfloxacinCurcumin may increase the neuroexcitatory activities of Ofloxacin.Approved
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Curcumin.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Curcumin.Approved
OleandrinOleandrin may decrease the cardiotoxic activities of Curcumin.Experimental, Investigational
Oleoyl-estroneThe risk or severity of adverse effects can be increased when Curcumin is combined with Oleoyl-estrone.Investigational
OlmesartanThe risk or severity of adverse effects can be increased when Olmesartan is combined with Curcumin.Approved, Investigational
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Curcumin.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Curcumin.Approved
OlsalazineCurcumin may increase the nephrotoxic activities of Olsalazine.Approved
Omacetaxine mepesuccinateThe risk or severity of bleeding can be increased when Curcumin is combined with Omacetaxine mepesuccinate.Approved, Investigational
OmapatrilatThe risk or severity of adverse effects can be increased when Curcumin is combined with Omapatrilat.Investigational
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Curcumin.Approved
OpiumThe metabolism of Opium can be decreased when combined with Curcumin.Approved, Illicit
OrgoteinThe risk or severity of adverse effects can be increased when Orgotein is combined with Curcumin.Vet Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Curcumin.Approved
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Curcumin.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Curcumin.Approved, Investigational
OtamixabanCurcumin may increase the anticoagulant activities of Otamixaban.Investigational
OuabainOuabain may decrease the cardiotoxic activities of Curcumin.Approved
OxaliplatinThe metabolism of Oxaliplatin can be decreased when combined with Curcumin.Approved, Investigational
OxaprozinThe risk or severity of adverse effects can be increased when Curcumin is combined with Oxaprozin.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Curcumin.Approved
Oxolinic acidCurcumin may increase the neuroexcitatory activities of Oxolinic acid.Experimental
OxprenololCurcumin may decrease the antihypertensive activities of Oxprenolol.Approved
OxtriphyllineThe metabolism of Oxtriphylline can be decreased when combined with Curcumin.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Curcumin.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
OxyphenbutazoneThe risk or severity of adverse effects can be increased when Oxyphenbutazone is combined with Curcumin.Approved, Withdrawn
PaclitaxelThe risk or severity of adverse effects can be increased when Paclitaxel is combined with Curcumin.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Curcumin.Approved, Investigational
PalmidrolThe risk or severity of adverse effects can be increased when Curcumin is combined with Palmidrol.Experimental, Nutraceutical
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Curcumin.Approved, Investigational
PamidronateThe risk or severity of adverse effects can be increased when Curcumin is combined with Pamidronate.Approved
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Curcumin.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Curcumin.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Curcumin.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Curcumin.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Curcumin.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Curcumin.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Curcumin.Approved, Investigational
ParomomycinCurcumin may decrease the excretion rate of Paromomycin which could result in a higher serum level.Approved, Investigational
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Curcumin.Approved, Investigational
ParthenolideThe risk or severity of adverse effects can be increased when Curcumin is combined with Parthenolide.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Curcumin.Approved
PazufloxacinCurcumin may increase the neuroexcitatory activities of Pazufloxacin.Investigational
PefloxacinCurcumin may increase the neuroexcitatory activities of Pefloxacin.Approved
PenbutololCurcumin may decrease the antihypertensive activities of Penbutolol.Approved, Investigational
Pentaerythritol TetranitrateCurcumin may increase the anticoagulant activities of Pentaerythritol Tetranitrate.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Curcumin.Approved, Investigational
Pentosan PolysulfateCurcumin may increase the anticoagulant activities of Pentosan Polysulfate.Approved
PentoxifyllineThe metabolism of Pentoxifylline can be decreased when combined with Curcumin.Approved, Investigational
PerampanelThe metabolism of Perampanel can be decreased when combined with Curcumin.Approved
PergolideThe risk or severity of adverse effects can be increased when Pergolide is combined with Curcumin.Approved, Investigational, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Curcumin.Approved, Investigational
PerindoprilThe risk or severity of adverse effects can be increased when Curcumin is combined with Perindopril.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Curcumin.Approved, Investigational
PerospironeThe metabolism of Perospirone can be decreased when combined with Curcumin.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Curcumin.Approved
PeruvosidePeruvoside may decrease the cardiotoxic activities of Curcumin.Experimental
PethidineThe metabolism of Pethidine can be decreased when combined with Curcumin.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Curcumin.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Curcumin.Approved, Investigational, Withdrawn
PhenindioneCurcumin may increase the anticoagulant activities of Phenindione.Approved, Investigational
PhenobarbitalThe metabolism of Phenobarbital can be decreased when combined with Curcumin.Approved, Investigational
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Curcumin.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Curcumin.Approved, Investigational
PhenylbutazoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Phenylbutazone.Approved, Vet Approved
PhenytoinThe metabolism of Phenytoin can be decreased when combined with Curcumin.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Curcumin.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Curcumin.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Curcumin.Approved
PindololCurcumin may decrease the antihypertensive activities of Pindolol.Approved, Investigational
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Curcumin.Approved, Investigational
Pipemidic acidCurcumin may increase the neuroexcitatory activities of Pipemidic acid.Experimental
PiperaquineThe metabolism of Piperaquine can be decreased when combined with Curcumin.Approved, Investigational
PiperazineThe metabolism of Piperazine can be decreased when combined with Curcumin.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Curcumin.Approved, Investigational
PiretanideThe therapeutic efficacy of Piretanide can be decreased when used in combination with Curcumin.Approved
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Curcumin.Approved, Investigational
Piromidic acidCurcumin may increase the neuroexcitatory activities of Piromidic acid.Experimental
PiroxicamThe risk or severity of adverse effects can be increased when Curcumin is combined with Piroxicam.Approved, Investigational
PirprofenThe risk or severity of adverse effects can be increased when Curcumin is combined with Pirprofen.Experimental
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Curcumin.Approved
PitolisantThe serum concentration of Pitolisant can be increased when it is combined with Curcumin.Approved, Investigational
Platelet Activating FactorCurcumin may decrease the antihypertensive activities of Platelet Activating Factor.Experimental
PlazomicinCurcumin may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
PodofiloxThe metabolism of Podofilox can be decreased when combined with Curcumin.Approved
PolythiazideThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Curcumin.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Curcumin is combined with Pomalidomide.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Curcumin.Approved, Investigational
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
Potassium CitrateCurcumin may increase the anticoagulant activities of Potassium Citrate.Approved, Investigational, Vet Approved
PractololCurcumin may decrease the antihypertensive activities of Practolol.Approved
PralatrexateThe serum concentration of Pralatrexate can be increased when it is combined with Curcumin.Approved, Investigational
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Curcumin.Approved, Investigational
PranoprofenThe risk or severity of adverse effects can be increased when Curcumin is combined with Pranoprofen.Experimental, Investigational
PrasteroneThe metabolism of Prasterone can be decreased when combined with Curcumin.Approved, Investigational, Nutraceutical
Prasterone sulfateThe risk or severity of adverse effects can be increased when Curcumin is combined with Prasterone sulfate.Investigational
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Curcumin resulting in a loss in efficacy.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Curcumin.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Curcumin.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
PrednicarbateThe risk or severity of adverse effects can be increased when Curcumin is combined with Prednicarbate.Approved, Investigational
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Curcumin.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Curcumin.Approved, Vet Approved
PregnenoloneThe risk or severity of adverse effects can be increased when Curcumin is combined with Pregnenolone.Approved, Experimental, Investigational
PrimaquineThe metabolism of Primaquine can be decreased when combined with Curcumin.Approved
ProbenecidThe serum concentration of Curcumin can be increased when it is combined with Probenecid.Approved, Investigational
ProcainamideThe metabolism of Procainamide can be decreased when combined with Curcumin.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Curcumin.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Curcumin.Approved, Vet Approved
ProglumetacinThe risk or severity of adverse effects can be increased when Curcumin is combined with Proglumetacin.Experimental
ProguanilThe metabolism of Proguanil can be decreased when combined with Curcumin.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Curcumin.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be decreased when combined with Curcumin.Approved, Investigational
PropacetamolThe risk or severity of adverse effects can be increased when Propacetamol is combined with Curcumin.Approved, Investigational
PropafenoneThe serum concentration of Curcumin can be increased when it is combined with Propafenone.Approved
PropiverineThe metabolism of Propiverine can be decreased when combined with Curcumin.Approved, Investigational
PropofolThe metabolism of Propofol can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Curcumin.Approved, Investigational
PropyphenazoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Propyphenazone.Experimental
ProquazoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Proquazone.Experimental
ProscillaridinProscillaridin may decrease the cardiotoxic activities of Curcumin.Experimental
Prostaglandin B2The therapeutic efficacy of Prostaglandin B2 can be decreased when used in combination with Curcumin.Experimental
Prostaglandin G2The therapeutic efficacy of Prostaglandin G2 can be decreased when used in combination with Curcumin.Experimental
ProstaleneThe therapeutic efficacy of Prostalene can be decreased when used in combination with Curcumin.Vet Approved
Protein CCurcumin may increase the anticoagulant activities of Protein C.Approved
Protein S humanCurcumin may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeCurcumin may increase the anticoagulant activities of Protocatechualdehyde.Approved
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Curcumin.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Curcumin.Approved
PrulifloxacinCurcumin may increase the neuroexcitatory activities of Prulifloxacin.Investigational
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Curcumin.Approved
PTC299The risk or severity of adverse effects can be increased when PTC299 is combined with Curcumin.Investigational
PuromycinCurcumin may decrease the excretion rate of Puromycin which could result in a higher serum level.Experimental
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Curcumin.Approved, Investigational
QuazepamThe metabolism of Quazepam can be decreased when combined with Curcumin.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Curcumin.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Curcumin.Approved, Investigational
QuinaprilThe risk or severity of adverse effects can be increased when Curcumin is combined with Quinapril.Approved, Investigational
QuinethazoneThe therapeutic efficacy of Quinethazone can be decreased when used in combination with Curcumin.Approved
QuinidineThe metabolism of Quinidine can be decreased when combined with Curcumin.Approved, Investigational
QuinineThe metabolism of Quinine can be decreased when combined with Curcumin.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Curcumin.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Curcumin.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Curcumin.Approved, Investigational
RamiprilThe risk or severity of adverse effects can be increased when Curcumin is combined with Ramipril.Approved
RanitidineThe metabolism of Ranitidine can be decreased when combined with Curcumin.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Curcumin.Approved, Investigational
RasagilineThe metabolism of Rasagiline can be decreased when combined with Curcumin.Approved
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Curcumin.Approved, Investigational
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Curcumin.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Curcumin.Approved, Withdrawn
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Curcumin.Approved, Investigational
RepinotanThe metabolism of Repinotan can be decreased when combined with Curcumin.Investigational
RescinnamineThe risk or severity of adverse effects can be increased when Curcumin is combined with Rescinnamine.Approved
ResveratrolThe risk or severity of adverse effects can be increased when Curcumin is combined with Resveratrol.Approved, Experimental, Investigational
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Curcumin.Approved
ReviparinCurcumin may increase the anticoagulant activities of Reviparin.Approved, Investigational
RibociclibThe serum concentration of Ribociclib can be increased when it is combined with Curcumin.Approved, Investigational
RibostamycinCurcumin may decrease the excretion rate of Ribostamycin which could result in a higher serum level.Approved, Investigational
RifabutinThe metabolism of Rifabutin can be decreased when combined with Curcumin.Approved, Investigational
RifampicinThe metabolism of Rifampicin can be decreased when combined with Curcumin.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Curcumin.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Curcumin.Approved
RiluzoleThe metabolism of Riluzole can be decreased when combined with Curcumin.Approved, Investigational
RimexoloneThe risk or severity of adverse effects can be increased when Curcumin is combined with Rimexolone.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Curcumin.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Curcumin.Approved
RisedronateThe risk or severity of adverse effects can be increased when Curcumin is combined with Risedronate.Approved, Investigational
RisperidoneThe metabolism of Risperidone can be decreased when combined with Curcumin.Approved, Investigational
RitonavirThe metabolism of Ritonavir can be decreased when combined with Curcumin.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Curcumin.Approved
RizatriptanThe metabolism of Rizatriptan can be decreased when combined with Curcumin.Approved
RofecoxibThe risk or severity of adverse effects can be increased when Curcumin is combined with Rofecoxib.Approved, Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Curcumin.Approved, Investigational
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Curcumin.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Curcumin.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Curcumin.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Curcumin.Approved, Investigational
RosoxacinCurcumin may increase the neuroexcitatory activities of Rosoxacin.Approved, Investigational
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Curcumin.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Curcumin.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Curcumin.Approved, Investigational, Withdrawn
RucaparibThe metabolism of Rucaparib can be decreased when combined with Curcumin.Approved, Investigational
RufloxacinCurcumin may increase the neuroexcitatory activities of Rufloxacin.Experimental
RupatadineThe metabolism of Rupatadine can be decreased when combined with Curcumin.Approved
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Curcumin.Approved
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Curcumin.Approved
SafinamideThe metabolism of Safinamide can be decreased when combined with Curcumin.Approved, Investigational
SalicylamideThe risk or severity of adverse effects can be increased when Salicylamide is combined with Curcumin.Approved
Salicylic acidThe risk or severity of adverse effects can be increased when Curcumin is combined with Salicylic acid.Approved, Investigational, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Curcumin.Approved
SalmeterolThe metabolism of Salmeterol can be decreased when combined with Curcumin.Approved
SalsalateThe risk or severity of adverse effects can be increased when Curcumin is combined with Salsalate.Approved
SaprisartanThe risk or severity of adverse effects can be increased when Saprisartan is combined with Curcumin.Experimental
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Curcumin.Approved, Investigational
SaralasinThe risk or severity of adverse effects can be increased when Saralasin is combined with Curcumin.Investigational
SarilumabSarilumab may increase the immunosuppressive activities of Curcumin.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Curcumin.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Curcumin.Approved
SeliciclibThe risk or severity of adverse effects can be increased when Curcumin is combined with Seliciclib.Investigational
SemapimodThe risk or severity of adverse effects can be increased when Curcumin is combined with Semapimod.Investigational
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Curcumin.Approved
SerrapeptaseThe risk or severity of adverse effects can be increased when Curcumin is combined with Serrapeptase.Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Curcumin.Approved, Investigational, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Curcumin.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Curcumin.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Curcumin.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Curcumin.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Curcumin.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Curcumin.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Curcumin.Approved, Investigational
SisomicinCurcumin may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
SitafloxacinCurcumin may increase the neuroexcitatory activities of Sitafloxacin.Experimental, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Curcumin.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Curcumin.Approved, Investigational, Withdrawn
Sodium CitrateCurcumin may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Sodium phosphate, monobasicSodium phosphate may increase the nephrotoxic activities of Curcumin.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Curcumin.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Curcumin.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Curcumin.Approved, Investigational
SotalolCurcumin may decrease the antihypertensive activities of Sotalol.Approved
SparfloxacinCurcumin may increase the neuroexcitatory activities of Sparfloxacin.Approved, Investigational
SparteineThe metabolism of Sparteine can be decreased when combined with Curcumin.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Curcumin.Approved
SpiraprilThe risk or severity of adverse effects can be increased when Curcumin is combined with Spirapril.Approved
SpironolactoneCurcumin may decrease the antihypertensive activities of Spironolactone.Approved
SRT501The risk or severity of adverse effects can be increased when SRT501 is combined with Curcumin.Investigational
StiripentolThe metabolism of Stiripentol can be decreased when combined with Curcumin.Approved
StreptomycinCurcumin may decrease the excretion rate of Streptomycin which could result in a higher serum level.Approved, Vet Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Curcumin.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Curcumin.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Curcumin.Approved
SulfasalazineThe risk or severity of adverse effects can be increased when Curcumin is combined with Sulfasalazine.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Curcumin.Approved
SulfisoxazoleThe metabolism of Sulfisoxazole can be decreased when combined with Curcumin.Approved, Vet Approved
SulindacThe risk or severity of adverse effects can be increased when Curcumin is combined with Sulindac.Approved, Investigational
SulodexideCurcumin may increase the anticoagulant activities of Sulodexide.Approved, Investigational
SulprostoneThe therapeutic efficacy of Sulprostone can be decreased when used in combination with Curcumin.Investigational
SunitinibThe metabolism of Sunitinib can be decreased when combined with Curcumin.Approved, Investigational
SuprofenThe risk or severity of adverse effects can be increased when Curcumin is combined with Suprofen.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Curcumin.Approved, Investigational
SuxibuzoneThe risk or severity of adverse effects can be increased when Curcumin is combined with Suxibuzone.Experimental
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Curcumin.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Curcumin.Approved
TacrineThe metabolism of Tacrine can be decreased when combined with Curcumin.Investigational, Withdrawn
TacrolimusCurcumin may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Curcumin.Approved, Investigational
TafluprostThe therapeutic efficacy of Tafluprost can be decreased when used in combination with Curcumin.Approved
TalinololCurcumin may decrease the antihypertensive activities of Talinolol.Investigational
TalniflumateThe risk or severity of adverse effects can be increased when Talniflumate is combined with Curcumin.Approved
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Curcumin resulting in a loss in efficacy.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Curcumin.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Curcumin.Approved
TarenflurbilThe risk or severity of adverse effects can be increased when Tarenflurbil is combined with Curcumin.Investigational
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Curcumin.Approved, Investigational
TasosartanThe metabolism of Tasosartan can be decreased when combined with Curcumin.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Curcumin.Experimental
Technetium Tc-99m etidronateThe risk or severity of adverse effects can be increased when Curcumin is combined with Technetium Tc-99m etidronate.Approved
Technetium Tc-99m medronateThe risk or severity of adverse effects can be increased when Curcumin is combined with Technetium Tc-99m medronate.Approved
TegaserodThe metabolism of Tegaserod can be decreased when combined with Curcumin.Approved, Investigational, Withdrawn
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Curcumin.Approved, Withdrawn
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Curcumin.Approved
TelmisartanThe risk or severity of adverse effects can be increased when Telmisartan is combined with Curcumin.Approved, Investigational
TemafloxacinCurcumin may increase the neuroexcitatory activities of Temafloxacin.Withdrawn
TemazepamThe metabolism of Temazepam can be decreased when combined with Curcumin.Approved, Investigational
TemocaprilThe risk or severity of adverse effects can be increased when Curcumin is combined with Temocapril.Experimental, Investigational
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Curcumin.Approved
TenidapThe risk or severity of adverse effects can be increased when Curcumin is combined with Tenidap.Experimental
TeniposideThe metabolism of Teniposide can be decreased when combined with Curcumin.Approved
Tenofovir disoproxilThe risk or severity of adverse effects can be increased when Curcumin is combined with Tenofovir disoproxil.Approved, Investigational
TenoxicamThe risk or severity of adverse effects can be increased when Curcumin is combined with Tenoxicam.Approved
TepoxalinThe risk or severity of adverse effects can be increased when Tepoxalin is combined with Curcumin.Vet Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
TerbutalineCurcumin may decrease the antihypertensive activities of Terbutaline.Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Curcumin.Approved, Withdrawn
TergurideThe risk or severity of adverse effects can be increased when Terguride is combined with Curcumin.Experimental
TeriflunomideThe risk or severity of adverse effects can be increased when Teriflunomide is combined with Curcumin.Approved
TertatololCurcumin may decrease the antihypertensive activities of Tertatolol.Experimental
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Curcumin.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Curcumin.Approved, Investigational
Testosterone cypionateThe metabolism of Testosterone cypionate can be decreased when combined with Curcumin.Approved
Testosterone enanthateThe metabolism of Testosterone enanthate can be decreased when combined with Curcumin.Approved
Testosterone propionateThe metabolism of Testosterone propionate can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved, Withdrawn
Testosterone undecanoateThe metabolism of Testosterone undecanoate can be decreased when combined with Curcumin.Approved, Investigational
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Curcumin.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Curcumin.Approved, Vet Approved
TezacaftorThe metabolism of Tezacaftor can be decreased when combined with Curcumin.Approved, Investigational
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Curcumin.Approved, Investigational, Withdrawn
TheobromineThe metabolism of Theobromine can be decreased when combined with Curcumin.Approved, Investigational
TheophyllineThe metabolism of Theophylline can be decreased when combined with Curcumin.Approved
ThiabendazoleThe metabolism of Thiabendazole can be decreased when combined with Curcumin.Approved, Vet Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Curcumin.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Curcumin.Approved, Withdrawn
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Curcumin.Approved, Investigational
ThiothixeneThe metabolism of Thiothixene can be decreased when combined with Curcumin.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Curcumin.Approved, Investigational
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Curcumin is combined with Tiaprofenic acid.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Curcumin resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Curcumin.Approved
Tiludronic acidThe risk or severity of adverse effects can be increased when Curcumin is combined with Tiludronic acid.Approved, Investigational, Vet Approved
TimololCurcumin may decrease the antihypertensive activities of Timolol.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Curcumin.Approved, Investigational
TinoridineThe risk or severity of adverse effects can be increased when Curcumin is combined with Tinoridine.Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Curcumin.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Curcumin.Approved, Investigational
TixocortolThe risk or severity of adverse effects can be increased when Curcumin is combined with Tixocortol.Approved, Withdrawn
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Curcumin.Approved, Investigational
TobramycinCurcumin may decrease the excretion rate of Tobramycin which could result in a higher serum level.Approved, Investigational
TocofersolanThe metabolism of Tocofersolan can be decreased when combined with Curcumin.Approved
TocopherolThe metabolism of Tocopherol can be decreased when combined with Curcumin.Approved, Investigational
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Curcumin.Approved, Investigational
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Curcumin.Approved, Investigational
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Tolfenamic Acid is combined with Curcumin.Approved, Investigational
TolmetinThe risk or severity of adverse effects can be increased when Curcumin is combined with Tolmetin.Approved
TolperisoneThe metabolism of Tolperisone can be decreased when combined with Curcumin.Approved, Investigational
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Curcumin.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Curcumin.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Curcumin.Approved, Investigational
TorasemideThe therapeutic efficacy of Torasemide can be decreased when used in combination with Curcumin.Approved
ToremifeneThe risk or severity of adverse effects can be increased when Curcumin is combined with Toremifene.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Curcumin.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Curcumin.Approved, Investigational
TrandolaprilThe risk or severity of adverse effects can be increased when Curcumin is combined with Trandolapril.Approved
TranilastThe risk or severity of adverse effects can be increased when Tranilast is combined with Curcumin.Approved, Investigational
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Curcumin.Approved, Investigational
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Curcumin.Approved, Investigational
TravoprostThe therapeutic efficacy of Travoprost can be decreased when used in combination with Curcumin.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Curcumin.Approved, Investigational
TreprostinilThe risk or severity of adverse effects can be increased when Treprostinil is combined with Curcumin.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Curcumin.Approved, Investigational, Nutraceutical
TriamcinoloneThe risk or severity of adverse effects can be increased when Curcumin is combined with Triamcinolone.Approved, Vet Approved
TriamtereneCurcumin may decrease the antihypertensive activities of Triamterene.Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Curcumin.Approved, Investigational
TribenosideThe risk or severity of adverse effects can be increased when Curcumin is combined with Tribenoside.Experimental
TrichlormethiazideThe therapeutic efficacy of Trichlormethiazide can be decreased when used in combination with Curcumin.Approved, Vet Approved
TrifluoperazineThe metabolism of Trifluoperazine can be decreased when combined with Curcumin.Approved, Investigational
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Curcumin.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Curcumin.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Curcumin.Approved
TriptolideThe risk or severity of adverse effects can be increased when Curcumin is combined with Triptolide.Investigational
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Curcumin.Investigational, Withdrawn
Trolamine salicylateThe risk or severity of adverse effects can be increased when Curcumin is combined with Trolamine salicylate.Approved
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Curcumin.Approved
TrovafloxacinCurcumin may increase the neuroexcitatory activities of Trovafloxacin.Approved, Investigational, Withdrawn
TroxerutinCurcumin may increase the anticoagulant activities of Troxerutin.Investigational
UdenafilThe metabolism of Udenafil can be decreased when combined with Curcumin.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Curcumin.Approved
UlobetasolThe risk or severity of adverse effects can be increased when Curcumin is combined with Ulobetasol.Approved
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Curcumin.Approved
UnoprostoneThe therapeutic efficacy of Unoprostone can be decreased when used in combination with Curcumin.Approved, Investigational
VadimezanThe metabolism of Vadimezan can be decreased when combined with Curcumin.Investigational
ValbenazineThe metabolism of Valbenazine can be decreased when combined with Curcumin.Approved, Investigational
ValdecoxibThe risk or severity of adverse effects can be increased when Curcumin is combined with Valdecoxib.Approved, Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Curcumin.Approved, Investigational
ValsartanThe metabolism of Valsartan can be decreased when combined with Curcumin.Approved, Investigational
VancomycinThe serum concentration of Vancomycin can be increased when it is combined with Curcumin.Approved
VandetanibThe metabolism of Vandetanib can be decreased when combined with Curcumin.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Curcumin.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Curcumin.Approved
VelpatasvirThe metabolism of Velpatasvir can be decreased when combined with Curcumin.Approved, Investigational
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Curcumin.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Curcumin.Approved, Investigational
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Curcumin.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Curcumin.Approved
VernakalantThe metabolism of Vernakalant can be decreased when combined with Curcumin.Approved, Investigational
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Curcumin.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Curcumin.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Curcumin.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Curcumin.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Curcumin.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Curcumin.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Curcumin.Approved, Investigational
VinflunineThe metabolism of Vinflunine can be decreased when combined with Curcumin.Approved, Investigational
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Curcumin.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Curcumin.Approved, Investigational
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Curcumin.Approved
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Curcumin.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Curcumin.Approved, Investigational
VoxilaprevirThe metabolism of Voxilaprevir can be decreased when combined with Curcumin.Approved, Investigational
WarfarinThe metabolism of Warfarin can be decreased when combined with Curcumin.Approved
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Curcumin.Approved, Investigational, Withdrawn
YohimbineThe metabolism of Yohimbine can be decreased when combined with Curcumin.Approved, Investigational, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Curcumin.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Curcumin.Approved, Investigational
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Curcumin.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Curcumin.Approved, Investigational
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Curcumin.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Curcumin.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Curcumin.Approved
ZofenoprilThe risk or severity of adverse effects can be increased when Curcumin is combined with Zofenopril.Experimental
Zoledronic acidThe risk or severity of adverse effects can be increased when Curcumin is combined with Zoledronic acid.Approved
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Curcumin.Approved, Investigational
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Curcumin.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Curcumin.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Curcumin.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Curcumin.Approved
ZotepineThe metabolism of Zotepine can be decreased when combined with Curcumin.Approved, Investigational, Withdrawn
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Curcumin.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. Gupta SC, Patchva S, Aggarwal BB: Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013 Jan;15(1):195-218. doi: 10.1208/s12248-012-9432-8. Epub 2012 Nov 10. [PubMed:23143785]
  2. European Medicines Agency (EMA): Assessment report on Curcuma xanthorrhiza Roxb. (C. xanthorrhiza D. Dietrich)., rhizoma [File]
External Links
Human Metabolome Database
HMDB0002269
PubChem Compound
969516
PubChem Substance
347828040
ChemSpider
839564
BindingDB
50140172
ChEBI
3962
ChEMBL
CHEMBL140
Wikipedia
Curcumin
MSDS
Download (48 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingTreatmentCervical Intraepithelial Neoplasia (CIN)1
0RecruitingTreatmentMetastatic Colon Cancer1
0Unknown StatusTreatmentRheumatoid Arthritis1
1CompletedNot AvailableColorectal Cancers1
1CompletedOtherComparative Multidose Pharmacokinetics1
1CompletedTreatmentCrohn's Disease (CD) / Inflammatory Bowel Diseases (IBD) / Ulcerative Colitis (UC)1
1CompletedTreatmentDentist-Patient Relations1
1CompletedTreatmentUterine Cervical Dysplasia1
1RecruitingSupportive CareBladder Spasms / Neoplasms, Malignant / Pain / Urination urgency of1
1Unknown StatusTreatmentHyperprolactinoma1
1WithdrawnTreatmentAdvanced Cancers1
1, 2CompletedTreatmentAlzheimer's Disease (AD)1
1, 2CompletedTreatmentCognition / Psychosis / Schizophrenic Disorders1
1, 2CompletedTreatmentHealthy Volunteers (Middle-aged Smokers)1
1, 2RecruitingTreatmentGulf War Syndrome1
1, 2RecruitingTreatmentMucositis1
1, 2RecruitingTreatmentPrimary Sclerosing Cholangitis (PSC)1
1, 2WithdrawnSupportive CareLung Cancer Non-Small Cell Cancer (NSCLC)1
2Active Not RecruitingSupportive CareProstate Cancer1
2Active Not RecruitingTreatmentProstate Cancer Metastatic Castration Resistant1
2Active Not RecruitingTreatmentRectal Carcinoma1
2CompletedPreventionHealthy, no Evidence of Disease / Tobacco Use Disorders1
2CompletedSupportive CareAge-associated Cognitive Impairment / Mild Cognitive Impairment (MCI)1
2CompletedSupportive CareCarcinoma, Breast / Pain / Radiation-Induced Dermatitis / Stage 0 Breast Cancer1
2CompletedTreatmentAdenocarcinomas / Neoplasms, Pancreatic1
2CompletedTreatmentCancer, Breast1
2CompletedTreatmentDisseminated Sclerosis1
2CompletedTreatmentFamilial Adenomatous Polyposis (FAP)1
2CompletedTreatmentMalignant Neoplasm of Pancreas1
2CompletedTreatmentOral Lichen Planus1
2RecruitingPreventionChronic Atrophic Gastritis (CAG) / Helicobacter Pylori Negative / Intestinal Metaplasia of Gastric Mucosa1
2RecruitingPreventionMild Cognitive Impairment (MCI)1
2RecruitingTreatmentAdvanced Breast Cancer / Metastatic Breast Cancer (MBC)1
2RecruitingTreatmentBipolar Disorder (BD)1
2RecruitingTreatmentCancer, Breast1
2RecruitingTreatmentChronic Kidney Disease (CKD) / Cognitive Decline1
2RecruitingTreatmentNeoplasms1
2RecruitingTreatmentOral Submucous Fibrosis1
2WithdrawnNot AvailableFamilial Adenomatous Polyposis (FAP)1
2WithdrawnTreatmentCutaneous T-Cell Lymphoma (CTCL)1
2WithdrawnTreatmentMultiple Myeloma (MM)1
2, 3CompletedPreventionAbdominal Aortic Aneurysms (AAA) / Acute Kidney Injury (AKI)1
2, 3CompletedPreventionRadiation-Induced Dermatitis1
2, 3RecruitingPreventionCognitive Function / Older Adults / Physical Function1
3CompletedTreatmentOptic Atrophy, Hereditary, Leber1
3CompletedTreatmentOsteoarthritis (OA)1
3CompletedTreatmentProteinuria1
3RecruitingTreatmentCrohn's Disease (CD)1
3RecruitingTreatmentProstate Cancer1
3Unknown StatusNot AvailableMalignant Neoplasm of Pancreas1
3Unknown StatusTreatmentColon Neoplasms1
4CompletedTreatmentMajor Depressive Disorder (MDD)1
4RecruitingTreatmentAutosomal Dominant Polycystic Kidney Disease (ADPKD)1
4RecruitingTreatmentChronic Schizophrenia1
4Unknown StatusPreventionCardiovascular Risks / Insulin Resistance / Pre-Diabetic / Type 2 Diabetes Mellitus1
4Unknown StatusTreatmentCardiovascular Abnormalities / Type 2 Diabetes Mellitus1
Not AvailableCompletedPreventionChronic Obstructive Pulmonary Disease (COPD)1
Not AvailableCompletedTreatmentFamilial Adenomatous Polyposis (FAP)1
Not AvailableCompletedTreatmentHealthy Volunteers1
Not AvailableCompletedTreatmentMultiple Myeloma (MM)1
Not AvailableTerminatedPreventionAberrant Crypt Foci1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)183MSDS
water solubilityInsoluble in cold waterMSDS
Predicted Properties
PropertyValueSource
Water Solubility0.00575 mg/mLALOGPS
logP3.62ALOGPS
logP4.12ChemAxon
logS-4.8ALOGPS
pKa (Strongest Acidic)9.06ChemAxon
pKa (Strongest Basic)-4.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area93.06 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity103.81 m3·mol-1ChemAxon
Polarizability38.12 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-0fbc-0923000000-107f42bbc825be91449b
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-ITTOF , negativeLC-MS/MSsplash10-0600-0920000000-c006d38848959c621ec5
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-014i-0982000000-2c508f0e4a39ae290728
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-00di-0950000000-af821cd7589af1e24d16
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0fk9-0981000000-e4da18f81a545b08874b
MS/MS Spectrum - , positiveLC-MS/MSsplash10-002b-2920000000-3c3aa8613bf16651cdf5

Taxonomy

Description
This compound belongs to the class of organic compounds known as curcuminoids. These are aromatic compounds containing a curcumin moiety, which is composed of two aryl buten-2-one (feruloyl) chromophores joined by a methylene group.
Kingdom
Organic compounds
Super Class
Phenylpropanoids and polyketides
Class
Diarylheptanoids
Sub Class
Linear diarylheptanoids
Direct Parent
Curcuminoids
Alternative Parents
Hydroxycinnamic acids and derivatives / Methoxyphenols / Styrenes / Phenoxy compounds / Methoxybenzenes / Anisoles / Beta-diketones / Alkyl aryl ethers / 1-hydroxy-2-unsubstituted benzenoids / Enones
show 4 more
Substituents
Curcumin / Hydroxycinnamic acid or derivatives / Methoxyphenol / Anisole / Phenoxy compound / Phenol ether / Styrene / Methoxybenzene / Phenol / 1,3-diketone
show 16 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
aromatic ether, enone, polyphenol, beta-diketone, diarylheptanoid (CHEBI:3962)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE...
Gene Name
PPARG
Uniprot ID
P37231
Uniprot Name
Peroxisome proliferator-activated receptor gamma
Molecular Weight
57619.58 Da
References
  1. Nishiyama T, Mae T, Kishida H, Tsukagawa M, Mimaki Y, Kuroda M, Sashida Y, Takahashi K, Kawada T, Nakagawa K, Kitahara M: Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. J Agric Food Chem. 2005 Feb 23;53(4):959-63. [PubMed:15713005]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B...
Gene Name
VDR
Uniprot ID
P11473
Uniprot Name
Vitamin D3 receptor
Molecular Weight
48288.64 Da
References
  1. Bartik L, Whitfield GK, Kaczmarska M, Lowmiller CL, Moffet EW, Furmick JK, Hernandez Z, Haussler CA, Haussler MR, Jurutka PW: Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention. J Nutr Biochem. 2010 Dec;21(12):1153-61. doi: 10.1016/j.jnutbio.2009.09.012. Epub 2010 Feb 12. [PubMed:20153625]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Organic anion transmembrane transporter activity
Specific Function
Acts as a multispecific organic anion pump which can transport nucleotide analogs.
Gene Name
ABCC5
Uniprot ID
O15440
Uniprot Name
Multidrug resistance-associated protein 5
Molecular Weight
160658.8 Da
References
  1. Prehm P: Curcumin analogue identified as hyaluronan export inhibitor by virtual docking to the ABC transporter MRP5. Food Chem Toxicol. 2013 Dec;62:76-81. doi: 10.1016/j.fct.2013.08.028. Epub 2013 Aug 24. [PubMed:23978416]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Curator comments
Non-competitive inhibitor
General Function
Prostaglandin-e2 9-reductase activity
Specific Function
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. ...
Gene Name
CBR1
Uniprot ID
P16152
Uniprot Name
Carbonyl reductase [NADPH] 1
Molecular Weight
30374.73 Da
References
  1. Hintzpeter J, Hornung J, Ebert B, Martin HJ, Maser E: Curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase--Carbonyl reductase 1. Chem Biol Interact. 2015 Jun 5;234:162-8. doi: 10.1016/j.cbi.2014.12.019. Epub 2014 Dec 22. [PubMed:25541467]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Curator comments
Irreversibly inhibits the enzyme via covalent modification at high concentrations. At low concentrations enzyme activity may be modified but not entirely inhibited by covalent binding.
General Function
S-nitrosoglutathione binding
Specific Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Gene Name
GSTP1
Uniprot ID
P09211
Uniprot Name
Glutathione S-transferase P
Molecular Weight
23355.625 Da
References
  1. van Iersel ML, Ploemen JP, Lo Bello M, Federici G, van Bladeren PJ: Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1. Chem Biol Interact. 1997 Dec 12;108(1-2):67-78. [PubMed:9463521]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Inhibitor
Curator comments
Curcumin is expected to be a moderate to strong inhibitor of CYP 2C9.
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Volak LP, Ghirmai S, Cashman JR, Court MH: Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. Drug Metab Dispos. 2008 Aug;36(8):1594-605. doi: 10.1124/dmd.108.020552. Epub 2008 May 14. [PubMed:18480186]
  2. European Medicines Agency (EMA): Assessment report on Curcuma xanthorrhiza Roxb. (C. xanthorrhiza D. Dietrich)., rhizoma [File]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Volak LP, Ghirmai S, Cashman JR, Court MH: Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. Drug Metab Dispos. 2008 Aug;36(8):1594-605. doi: 10.1124/dmd.108.020552. Epub 2008 May 14. [PubMed:18480186]
  2. European Medicines Agency (EMA): Assessment report on Curcuma xanthorrhiza Roxb. (C. xanthorrhiza D. Dietrich)., rhizoma [File]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. European Medicines Agency (EMA): Assessment report on Curcuma xanthorrhiza Roxb. (C. xanthorrhiza D. Dietrich)., rhizoma [File]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. European Medicines Agency (EMA): Assessment report on Curcuma xanthorrhiza Roxb. (C. xanthorrhiza D. Dietrich)., rhizoma [File]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. European Medicines Agency (EMA): Assessment report on Curcuma xanthorrhiza Roxb. (C. xanthorrhiza D. Dietrich)., rhizoma [File]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Glutathione transferase activity
Specific Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Gene Name
GSTA1
Uniprot ID
P08263
Uniprot Name
Glutathione S-transferase A1
Molecular Weight
25630.785 Da
References
  1. European Medicines Agency (EMA): Assessment report on Curcuma xanthorrhiza Roxb. (C. xanthorrhiza D. Dietrich)., rhizoma [File]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Protein homodimerization activity
Specific Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Gene Name
GSTM1
Uniprot ID
P09488
Uniprot Name
Glutathione S-transferase Mu 1
Molecular Weight
25711.555 Da
References
  1. European Medicines Agency (EMA): Assessment report on Curcuma xanthorrhiza Roxb. (C. xanthorrhiza D. Dietrich)., rhizoma [File]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
S-nitrosoglutathione binding
Specific Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Gene Name
GSTP1
Uniprot ID
P09211
Uniprot Name
Glutathione S-transferase P
Molecular Weight
23355.625 Da
References
  1. European Medicines Agency (EMA): Assessment report on Curcuma xanthorrhiza Roxb. (C. xanthorrhiza D. Dietrich)., rhizoma [File]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. European Medicines Agency (EMA): Assessment report on Curcuma xanthorrhiza Roxb. (C. xanthorrhiza D. Dietrich)., rhizoma [File]

Drug created on October 20, 2016 14:38 / Updated on July 02, 2018 20:53