Meningococcal Meningitis

Also known as: Meningitis, Meningococcal / Neisseria meningitides meningitis / Meningitis meningococcal

DrugDrug NameDrug Description
DB01053BenzylpenicillinBenzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as *Streptococcus pneumoniae*, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (*S. agalactiae*), *S. viridans*, and *Enterococcus faecalis*. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as *Bacillus anthracis*, *Corynebacterium diphtheriae*, and *Erysipelothrix rhusiopathiae*. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by *Neisseria meningitidis* and *Pasteurella*. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
DB01017MinocyclineA tetracycline analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant staphylococcus infections. [PubChem]
DB00359SulfadiazineOne of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. [PubChem]
DB05294VandetanibVandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients.
DrugDrug NameTargetType
DB01053BenzylpenicillinSolute carrier family 22 member 5transporter
DB01053BenzylpenicillinSolute carrier family 15 member 1transporter
DB01053BenzylpenicillinSolute carrier family 15 member 2transporter
DB01053BenzylpenicillinSolute carrier family 22 member 6transporter
DB01053BenzylpenicillinSolute carrier family 22 member 8transporter
DB01053BenzylpenicillinSolute carrier family 22 member 4transporter
DB01053BenzylpenicillinSolute carrier family 22 member 11transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 2B1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 4A1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 3A1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 1B1transporter
DB01053BenzylpenicillinPenicillin-binding protein 3target
DB01053BenzylpenicillinBeta-lactamase TEMtarget
DB01053BenzylpenicillinSolute carrier family 22 member 8target
DB01053BenzylpenicillinSolute carrier family 15 member 1target
DB01053BenzylpenicillinSolute carrier family 15 member 2target
DB01017Minocycline30S ribosomal protein S4target
DB01017Minocycline30S ribosomal protein S9target
DB01017Minocycline16S rRNAtarget
DB01017MinocyclineInterleukin-1 betatarget
DB01017MinocyclineArachidonate 5-lipoxygenasetarget
DB01017MinocyclineMatrix metalloproteinase-9target
DB01017MinocyclineVascular endothelial growth factor Atarget
DB01017MinocyclineCaspase-1target
DB01017MinocyclineCaspase-3target
DB01017MinocyclineCytochrome ctarget
DB01017MinocyclineSolute carrier family 22 member 6transporter
DB01017MinocyclineSolute carrier family 22 member 8transporter
DB01017MinocyclineSolute carrier family 22 member 11transporter
DB01017MinocyclineSolute carrier family 22 member 7transporter
DB00359SulfadiazineCytochrome P450 2C9enzyme
DB00359SulfadiazineDihydropteroate synthetasetarget
DB00359SulfadiazineCytochrome P450 2C8enzyme
DB00359SulfadiazineCytochrome P450 2E1enzyme
DB00359SulfadiazineCytochrome P450 3A4enzyme
DB05294VandetanibVascular endothelial growth factor Atarget
DB05294VandetanibEpidermal growth factor receptortarget
DB05294VandetanibMultidrug resistance-associated protein 1transporter
DB05294VandetanibATP-binding cassette sub-family G member 2transporter
DB05294VandetanibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB05294VandetanibDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB05294VandetanibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB05294VandetanibProtein-tyrosine kinase 6target
DB05294VandetanibAngiopoietin-1 receptortarget
DB05294VandetanibAlpha-1-acid glycoprotein 1carrier
DB05294VandetanibSerum albumincarrier
DB05294VandetanibCytochrome P450 3A4enzyme
DrugDrug NamePhaseStatusCount
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen1 / 2Completed1
DB11121Chloroxylenol2Completed1
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)2Completed1
DB10300Human papillomavirus type 11 L1 capsid protein antigen2Completed1
DB13887Meningococcal Polysaccharide Vaccine Group W-1352Completed1
DB13887Meningococcal Polysaccharide Vaccine Group W-1352Not Yet Recruiting1
DB13888Meningococcal Polysaccharide Vaccine Group Y2Completed1
DB13888Meningococcal Polysaccharide Vaccine Group Y2Not Yet Recruiting1
DB13889Meningococcal group A polysaccharide2Completed1
DB13889Meningococcal group A polysaccharide2Not Yet Recruiting1
DB13890Meningococcal group C polysaccharide2Completed1
DB13890Meningococcal group C polysaccharide2Not Yet Recruiting1
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen2Active Not Recruiting1
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen2Completed3
DB11121Chloroxylenol3Completed1
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)3Completed2
DB10076Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen3Completed1
DB13887Meningococcal Polysaccharide Vaccine Group W-1353Completed1
DB13888Meningococcal Polysaccharide Vaccine Group Y3Completed1
DB13889Meningococcal group A polysaccharide3Completed1
DB13890Meningococcal group C polysaccharide3Completed2
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen3Completed4
DB00299Penciclovir3Completed1
DB10283Rabies virus inactivated antigen, A3Completed1
DB10805Yellow Fever Vaccine3Completed1
DB00537Ciprofloxacin4Completed1
DB00537Ciprofloxacin4Not Yet Recruiting1
DB13887Meningococcal Polysaccharide Vaccine Group W-1354Recruiting1
DB13888Meningococcal Polysaccharide Vaccine Group Y4Recruiting1
DB13889Meningococcal group A polysaccharide4Recruiting1
DB13890Meningococcal group C polysaccharide4Recruiting1
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen4Active Not Recruiting1
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen4Completed2
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigenNot AvailableCompleted1