Identification

Name
Ciprofloxacin
Accession Number
DB00537  (APRD00424, EXPT00999)
Type
Small Molecule
Groups
Approved, Investigational
Description

Ciprofloxacin is a broad-spectrum antimicrobial carboxyfluoroquinoline.The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, strand supercoiling repair, and recombination.

Structure
Thumb
Synonyms
  • 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
  • 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
  • 1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid
  • 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
  • 1-Cyclopropyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
  • 1-cyclopropyl-6-fluoro-7-hexahydro-1-pyrazinyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
  • Ciprofloxacine
  • Ciprofloxacino
  • Ciprofloxacinum
External IDs
BAY Q 3939 / BAY-Q-3939 / BAYQ3939 / J01MA02
Product Ingredients
IngredientUNIICASInChI Key
Ciprofloxacin hydrochloride0MP32MFP6C93107-08-5DIOIOSKKIYDRIQ-UHFFFAOYSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act CiprofloxacinTablet500 mgOralTeva2004-02-18Not applicableCanada
Act CiprofloxacinTablet250 mgOralTeva2004-02-18Not applicableCanada
Act CiprofloxacinTablet750 mgOralTeva2004-02-18Not applicableCanada
CetraxalSolution / drops.5 mg/.25mLAuricular (otic)Wraser Llc2009-05-14Not applicableUs
CiloxanOintment0.3 %OphthalmicNovartis1998-10-07Not applicableCanada
CiloxanSolution / drops3 mg/mLOphthalmicAlcon, Inc.1991-01-15Not applicableUs
CiloxanSolution0.3 %OphthalmicNovartis1992-12-31Not applicableCanada
CiloxanSolution3.5 mg/mLOphthalmicPhysicians Total Care, Inc.1995-07-10Not applicableUs
CiloxanOintment3 mg/gOphthalmicAlcon, Inc.1998-06-02Not applicableUs
CiproKitBayer1997-09-26Not applicableUs
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-ciprofloxSolution0.3 %OphthalmicApotex Corporation2005-09-14Not applicableCanada
Apo-ciprofloxTablet500 mgOralApotex Corporation2004-02-09Not applicableCanada
Apo-ciprofloxTablet250 mgOralApotex Corporation2004-02-09Not applicableCanada
Apo-ciprofloxTablet750 mgOralApotex Corporation2004-02-09Not applicableCanada
Auro-ciprofloxacinTablet500 mgOralAuro Pharma Inc2012-06-13Not applicableCanada
Auro-ciprofloxacinTablet250 mgOralAuro Pharma Inc2012-06-13Not applicableCanada
Auro-ciprofloxacinTablet750 mgOralAuro Pharma Inc2012-06-13Not applicableCanada
Bio-ciprofloxacinTablet500 mgOralBiomed Pharma2016-06-17Not applicableCanada
CiprofloxacinTablet, film coated500 mg/1OralQ Pharma Inc2006-11-01Not applicableUs
CiprofloxacinTablet, film coated250 mg/1OralA S Medication Solutions2007-04-262017-06-20Us
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
CiproCiprofloxacin (452.2 mg/1) + Ciprofloxacin hydrochloride (574.9 mg/1)Tablet, film coated, extended releaseOralBayer2012-10-01Not applicableUs
CiproCiprofloxacin hydrochloride (2 mg/1mL) + Benzyl alcohol (9 mg/1mL) + Hydrocortisone (10 mg/1mL)SuspensionAuricular (otic)Physicians Total Care, Inc.2009-02-12Not applicableUs
CiproCiprofloxacin (212.6 mg/1) + Ciprofloxacin hydrochloride (287.5 mg/1)Tablet, film coated, extended releaseOralBayer2012-10-01Not applicableUs
CiproCiprofloxacin (452.2 mg/1) + Ciprofloxacin hydrochloride (574.9 mg/1)Tablet, film coated, extended releaseOralBayer2012-10-01Not applicableUs
CiproCiprofloxacin (212.6 mg/1) + Ciprofloxacin hydrochloride (287.5 mg/1)Tablet, film coated, extended releaseOralBayer2012-10-01Not applicableUs
Cipro HCCiprofloxacin hydrochloride (2 mg/mL) + Hydrocortisone (10 mg/mL)SuspensionAuricular (otic)Alcon, Inc.1999-03-15Not applicableUs
Cipro HCCiprofloxacin hydrochloride (2 mg/mL) + Hydrocortisone (10 mg/mL)SuspensionAuricular (otic)A S Medication Solutions1999-03-152017-06-20Us
Cipro HCCiprofloxacin (2 mg/mL) + Benzyl alcohol (9 mg/mL) + Hydrocortisone (10 mg/mL)SuspensionAuricular (otic)Stat Rx USA1998-02-102018-02-08Us
Cipro HC Otic SuspensionCiprofloxacin (2 mg) + Hydrocortisone (10 mg)SuspensionAuricular (otic)Alcon, Inc.1999-06-222008-12-08Canada
CiprodexCiprofloxacin hydrochloride (3 mg/mL) + Dexamethasone (1 mg/mL)SuspensionAuricular (otic)Physicians Total Care, Inc.2004-09-21Not applicableUs
International/Other Brands
Bacquinor / Baycip / Ciflox / Cifloxin / Ciprinol / Ciprobay / Ciprocinol / Ciprodar / Ciproxan / Ciproxin / Flociprin / Proquin
Categories
UNII
5E8K9I0O4U
CAS number
85721-33-1
Weight
Average: 331.3415
Monoisotopic: 331.133219662
Chemical Formula
C17H18FN3O3
InChI Key
MYSWGUAQZAJSOK-UHFFFAOYSA-N
InChI
InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
IUPAC Name
1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
SMILES
OC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=O

Pharmacology

Indication

For the treatment of the following infections caused by susceptible organisms: urinary tract infections, acute uncomplicated cystitis, chronic bacterial prostatitis, lower respiratory tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections (used in combination with metronidazole), infectious diarrhea, typhoid fever (enteric fever), uncomplicated cervical and urethral gonorrhea, and inhalational anthrax (post-exposure).

Associated Conditions
Pharmacodynamics

Ciprofloxacin is a broad-spectrum antiinfective agent of the fluoroquinolone class. Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. The mechanism of action of quinolones, including ciprofloxacin, is different from that of other antimicrobial agents such as beta-lactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to ciprofloxacin. There is no known cross-resistance between ciprofloxacin and other classes of antimicrobials. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.

Mechanism of action

The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, strand supercoiling repair, and recombination.

TargetActionsOrganism
ADNA topoisomerase 4 subunit A
inhibitor
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
ADNA gyrase subunit A
inhibitor
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
UDNA topoisomerase 2-alpha
inhibitor
Human
UPotassium voltage-gated channel subfamily H member 2Not AvailableHuman
UDNA gyrase subunit ANot AvailableEscherichia coli (strain K12)
UDNA topoisomerase 4 subunit ANot AvailableStaphylococcus aureus
UDNA topoisomerase 4 subunit BNot AvailableBacillus subtilis (strain 168)
UDNA gyrase subunit ANot AvailableBacillus subtilis (strain 168)
UMultidrug resistance protein MdtKNot AvailableEscherichia coli
UGyrase ANot AvailableMycobacterium tuberculosis
UDNA gyrase subunit ANot AvailableStaphylococcus aureus
Absorption

Rapidly and well absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 70% with no substantial loss by first pass metabolism.

Volume of distribution
Not Available
Protein binding

20 to 40%

Metabolism

Hepatic. Four metabolites have been identified in human urine which together account for approximately 15% of an oral dose. The metabolites have antimicrobial activity, but are less active than unchanged ciprofloxacin.

Route of elimination

Approximately 40 to 50% of an orally administered dose is excreted in the urine as unchanged drug.

Half life

4 hours

Clearance
  • Renal cl=300 mL/min
Toxicity

The major adverse effect seen with use of is gastrointestinal irritation, common with many antibiotics.

Affected organisms
  • Enteric bacteria and other eubacteria
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limonene(4R)-limonene may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
16-BromoepiandrosteroneThe risk or severity of adverse effects can be increased when 16-Bromoepiandrosterone is combined with Ciprofloxacin.Investigational
19-norandrostenedioneThe risk or severity of adverse effects can be increased when 19-norandrostenedione is combined with Ciprofloxacin.Experimental, Illicit
3-isobutyl-1-methyl-7H-xanthineThe serum concentration of 3-isobutyl-1-methyl-7H-xanthine can be increased when it is combined with Ciprofloxacin.Experimental
5-androstenedioneThe risk or severity of adverse effects can be increased when 5-androstenedione is combined with Ciprofloxacin.Experimental, Illicit
AcarboseCiprofloxacin may increase the hypoglycemic activities of Acarbose.Approved, Investigational
AceclofenacAceclofenac may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
AcemetacinAcemetacin may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Experimental, Investigational
AcenocoumarolCiprofloxacin may increase the anticoagulant activities of Acenocoumarol.Approved, Investigational
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Ciprofloxacin.Approved
AcetyldigoxinAcetyldigoxin may decrease the cardiotoxic activities of Ciprofloxacin.Experimental
Acetylsalicylic acidAcetylsalicylic acid may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Vet Approved
AdapaleneAdapalene may increase the neuroexcitatory activities of Ciprofloxacin.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Ciprofloxacin.Approved
AlbiglutideCiprofloxacin may increase the hypoglycemic activities of Albiglutide.Approved
AlclofenacAlclofenac may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Withdrawn
AlclometasoneThe risk or severity of adverse effects can be increased when Alclometasone is combined with Ciprofloxacin.Approved
AldosteroneThe risk or severity of adverse effects can be increased when Aldosterone is combined with Ciprofloxacin.Experimental, Investigational
AlfuzosinAlfuzosin may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
AlmasilateAlmasilate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Experimental
AlminoprofenAlminoprofen may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
AlogliptinCiprofloxacin may increase the hypoglycemic activities of Alogliptin.Approved
AloglutamolAloglutamol can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
AluminiumAluminium can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Aluminium acetoacetateAluminium acetoacetate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
Aluminium glycinateAluminium glycinate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
Aluminum hydroxideAluminum hydroxide can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
AmantadineAmantadine may increase the QTc-prolonging activities of Ciprofloxacin.Approved
Ambroxol acefyllinateThe metabolism of Ambroxol acefyllinate can be decreased when combined with Ciprofloxacin.Experimental, Investigational
AmcinonideThe risk or severity of adverse effects can be increased when Amcinonide is combined with Ciprofloxacin.Approved
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Ciprofloxacin.Approved
AmiodaroneCiprofloxacin may increase the QTc-prolonging activities of Amiodarone.Approved, Investigational
AmitriptylineAmitriptyline may increase the QTc-prolonging activities of Ciprofloxacin.Approved
AmoxapineAmoxapine may increase the QTc-prolonging activities of Ciprofloxacin.Approved
AnagrelideCiprofloxacin may increase the QTc-prolonging activities of Anagrelide.Approved
AncestimThe risk or severity of cytotoxicity can be increased when Ancestim is combined with Ciprofloxacin.Approved, Investigational, Withdrawn
AndrographolideAndrographolide may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
AndrostenedioneThe risk or severity of adverse effects can be increased when Androstenedione is combined with Ciprofloxacin.Experimental, Illicit
AnecortaveThe risk or severity of adverse effects can be increased when Anecortave is combined with Ciprofloxacin.Investigational
anecortave acetateThe risk or severity of adverse effects can be increased when anecortave acetate is combined with Ciprofloxacin.Investigational
AnisodamineAnisodamine may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
AntipyrineAntipyrine may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
ApalutamideThe serum concentration of Ciprofloxacin can be decreased when it is combined with Apalutamide.Approved, Investigational
ApocyninApocynin may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
ApomorphineApomorphine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
ApremilastApremilast may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
ArformoterolArformoterol may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
AripiprazoleAripiprazole may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
Arsenic trioxideCiprofloxacin may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherCiprofloxacin may increase the QTc-prolonging activities of Artemether.Approved
AsenapineCiprofloxacin may increase the QTc-prolonging activities of Asenapine.Approved
AsunaprevirThe serum concentration of Asunaprevir can be increased when it is combined with Ciprofloxacin.Approved, Investigational, Withdrawn
AtamestaneThe risk or severity of adverse effects can be increased when Atamestane is combined with Ciprofloxacin.Investigational
AtazanavirAtazanavir may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
AtomoxetineAtomoxetine may increase the QTc-prolonging activities of Ciprofloxacin.Approved
AtorvastatinThe risk or severity of adverse effects can be increased when Ciprofloxacin is combined with Atorvastatin.Approved
AzapropazoneAzapropazone may increase the neuroexcitatory activities of Ciprofloxacin.Withdrawn
AzelastineAzelastine may increase the neuroexcitatory activities of Ciprofloxacin.Approved
Azilsartan medoxomilAzilsartan medoxomil may increase the arrhythmogenic activities of Ciprofloxacin.Approved, Investigational
AzithromycinAzithromycin may increase the QTc-prolonging activities of Ciprofloxacin.Approved
BalsalazideBalsalazide may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
Beclomethasone dipropionateThe risk or severity of adverse effects can be increased when Beclomethasone dipropionate is combined with Ciprofloxacin.Approved, Investigational
BedaquilineCiprofloxacin may increase the QTc-prolonging activities of Bedaquiline.Approved
BenazeprilThe risk or severity of ventricular arrhythmias can be increased when Benazepril is combined with Ciprofloxacin.Approved, Investigational
BendazacBendazac may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
BenorilateBenorilate may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
BenoxaprofenBenoxaprofen may increase the neuroexcitatory activities of Ciprofloxacin.Withdrawn
BenzydamineBenzydamine may increase the neuroexcitatory activities of Ciprofloxacin.Approved
BetamethasoneThe risk or severity of adverse effects can be increased when Betamethasone is combined with Ciprofloxacin.Approved, Vet Approved
BevacizumabBevacizumab may increase the cardiotoxic activities of Ciprofloxacin.Approved, Investigational
BevoniumBevonium may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
Bismuth SubcitrateBismuth Subcitrate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Bismuth subnitrateBismuth subnitrate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
BortezomibBortezomib may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Ciprofloxacin.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Ciprofloxacin.Approved, Investigational
BromfenacBromfenac may increase the neuroexcitatory activities of Ciprofloxacin.Approved
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Ciprofloxacin.Approved, Investigational
BucillamineBucillamine may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
BudesonideThe risk or severity of adverse effects can be increased when Budesonide is combined with Ciprofloxacin.Approved
BufexamacBufexamac may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Experimental
BumadizoneBumadizone may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
BuserelinBuserelin may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
CabazitaxelThe risk or severity of adverse effects can be increased when Cabazitaxel is combined with Ciprofloxacin.Approved
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Ciprofloxacin.Approved
Calcium AcetateCalcium Acetate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Calcium CarbonateCalcium Carbonate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Calcium ChlorideCalcium Chloride can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Calcium CitrateCalcium Citrate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Calcium glubionateCalcium glubionate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Calcium GluceptateCalcium Gluceptate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Calcium gluconateCalcium gluconate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Vet Approved
Calcium lactateCalcium lactate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational, Vet Approved
Calcium lactate gluconateCalcium lactate gluconate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
Calcium levulinateCalcium levulinate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Experimental
Calcium pangamateCalcium pangamate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
Calcium PhosphateCalcium Phosphate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Calcium silicateCalcium silicate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
CanagliflozinCiprofloxacin may increase the hypoglycemic activities of Canagliflozin.Approved
CandesartanCandesartan may increase the arrhythmogenic activities of Ciprofloxacin.Experimental
Candesartan cilexetilCandesartan cilexetil may increase the arrhythmogenic activities of Ciprofloxacin.Approved
CandoxatrilThe risk or severity of ventricular arrhythmias can be increased when Candoxatril is combined with Ciprofloxacin.Experimental
CaptoprilThe risk or severity of ventricular arrhythmias can be increased when Captopril is combined with Ciprofloxacin.Approved
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Ciprofloxacin.Approved, Investigational
Carbaspirin calciumCarbaspirin calcium may increase the neuroexcitatory activities of Ciprofloxacin.Experimental, Investigational
CarprofenCarprofen may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Vet Approved, Withdrawn
CaseinCasein can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
CastanospermineCastanospermine may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
CelecoxibCelecoxib may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
CeritinibCiprofloxacin may increase the QTc-prolonging activities of Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Ciprofloxacin.Approved, Withdrawn
ChloroquineCiprofloxacin may increase the QTc-prolonging activities of Chloroquine.Approved, Investigational, Vet Approved
ChlorpromazineChlorpromazine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational, Vet Approved
ChlorpropamideCiprofloxacin may increase the hypoglycemic activities of Chlorpropamide.Approved, Investigational
Choline magnesium trisalicylateCholine magnesium trisalicylate may increase the neuroexcitatory activities of Ciprofloxacin.Approved
CiclesonideThe risk or severity of adverse effects can be increased when Ciclesonide is combined with Ciprofloxacin.Approved, Investigational
CilazaprilThe risk or severity of ventricular arrhythmias can be increased when Cilazapril is combined with Ciprofloxacin.Approved
CisaprideCiprofloxacin may increase the QTc-prolonging activities of Cisapride.Approved, Investigational, Withdrawn
CitalopramCiprofloxacin may increase the QTc-prolonging activities of Citalopram.Approved
ClarithromycinCiprofloxacin may increase the QTc-prolonging activities of Clarithromycin.Approved
ClobetasolThe risk or severity of adverse effects can be increased when Clobetasol is combined with Ciprofloxacin.Approved, Investigational
Clobetasol propionateThe risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Ciprofloxacin.Approved
ClobetasoneThe risk or severity of adverse effects can be increased when Clobetasone is combined with Ciprofloxacin.Approved
ClocortoloneThe risk or severity of adverse effects can be increased when Clocortolone is combined with Ciprofloxacin.Approved
ClomipramineClomipramine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational, Vet Approved
ClonixinClonixin may increase the neuroexcitatory activities of Ciprofloxacin.Approved
ClorindioneCiprofloxacin may increase the anticoagulant activities of Clorindione.Experimental
ClozapineCiprofloxacin may increase the QTc-prolonging activities of Clozapine.Approved
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Ciprofloxacin.Approved
Cortexolone 17α-propionateThe risk or severity of adverse effects can be increased when Cortexolone 17α-propionate is combined with Ciprofloxacin.Investigational
CorticosteroneThe risk or severity of adverse effects can be increased when Corticosterone is combined with Ciprofloxacin.Experimental
Cortisone acetateThe risk or severity of adverse effects can be increased when Cortisone acetate is combined with Ciprofloxacin.Approved, Investigational
CrizotinibCiprofloxacin may increase the QTc-prolonging activities of Crizotinib.Approved
CurcuminCurcumin may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Ciprofloxacin.Approved, Investigational
CymarinCymarin may decrease the cardiotoxic activities of Ciprofloxacin.Experimental
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Ciprofloxacin.Approved
DabrafenibDabrafenib may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
DapagliflozinCiprofloxacin may increase the hypoglycemic activities of Dapagliflozin.Approved
DasatinibDasatinib may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
DeflazacortThe risk or severity of adverse effects can be increased when Deflazacort is combined with Ciprofloxacin.Approved, Investigational
DegarelixDegarelix may increase the QTc-prolonging activities of Ciprofloxacin.Approved
DelamanidCiprofloxacin may increase the QTc-prolonging activities of Delamanid.Approved, Investigational
DelaprilThe risk or severity of ventricular arrhythmias can be increased when Delapril is combined with Ciprofloxacin.Experimental
DesfluraneDesflurane may increase the QTc-prolonging activities of Ciprofloxacin.Approved
DesipramineDesipramine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
DeslanosideDeslanoside may decrease the cardiotoxic activities of Ciprofloxacin.Approved
DesonideThe risk or severity of adverse effects can be increased when Desonide is combined with Ciprofloxacin.Approved, Investigational
DesoximetasoneThe risk or severity of adverse effects can be increased when Desoximetasone is combined with Ciprofloxacin.Approved
Desoxycorticosterone acetateThe risk or severity of adverse effects can be increased when Desoxycorticosterone acetate is combined with Ciprofloxacin.Approved
Desoxycorticosterone PivalateThe risk or severity of adverse effects can be increased when Desoxycorticosterone Pivalate is combined with Ciprofloxacin.Experimental, Vet Approved
DeutetrabenazineCiprofloxacin may increase the QTc-prolonging activities of Deutetrabenazine.Approved, Investigational
DexamethasoneThe risk or severity of adverse effects can be increased when Dexamethasone is combined with Ciprofloxacin.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe risk or severity of adverse effects can be increased when Dexamethasone isonicotinate is combined with Ciprofloxacin.Vet Approved
DiclofenacDiclofenac may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Vet Approved
DicoumarolCiprofloxacin may increase the anticoagulant activities of Dicoumarol.Approved
DidanosineThe serum concentration of Didanosine can be decreased when it is combined with Ciprofloxacin.Approved
DifenpiramideDifenpiramide may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
DiflorasoneThe risk or severity of adverse effects can be increased when Diflorasone is combined with Ciprofloxacin.Approved
DiflunisalDiflunisal may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
DifluocortoloneThe risk or severity of adverse effects can be increased when Difluocortolone is combined with Ciprofloxacin.Approved, Investigational, Withdrawn
DifluprednateThe risk or severity of adverse effects can be increased when Difluprednate is combined with Ciprofloxacin.Approved
DigitoxinDigitoxin may decrease the cardiotoxic activities of Ciprofloxacin.Approved, Investigational
DigoxinDigoxin may decrease the cardiotoxic activities of Ciprofloxacin.Approved
Digoxin Immune Fab (Ovine)Digoxin Immune Fab (Ovine) may decrease the cardiotoxic activities of Ciprofloxacin.Approved
DihydroergocornineThe risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Ciprofloxacin.Approved
DihydroergocristineThe risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Ciprofloxacin.Approved, Experimental
DihydroergocryptineThe risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Ciprofloxacin.Experimental
DihydroergotamineThe risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Ciprofloxacin.Approved, Investigational
DimenhydrinateThe serum concentration of Dimenhydrinate can be increased when it is combined with Ciprofloxacin.Approved
DiphenadioneCiprofloxacin may increase the anticoagulant activities of Diphenadione.Experimental
DiphenhydramineDiphenhydramine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
DisopyramideCiprofloxacin may increase the QTc-prolonging activities of Disopyramide.Approved
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Ciprofloxacin.Approved, Investigational
DofetilideCiprofloxacin may increase the QTc-prolonging activities of Dofetilide.Approved, Investigational
DolasetronCiprofloxacin may increase the QTc-prolonging activities of Dolasetron.Approved, Investigational
DomperidoneCiprofloxacin may increase the QTc-prolonging activities of Domperidone.Approved, Investigational, Vet Approved
DoxepinDoxepin may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Ciprofloxacin.Approved, Investigational
DronedaroneCiprofloxacin may increase the QTc-prolonging activities of Dronedarone.Approved
DroperidolDroperidol may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Vet Approved
DroxicamDroxicam may increase the neuroexcitatory activities of Ciprofloxacin.Withdrawn
DulaglutideCiprofloxacin may increase the hypoglycemic activities of Dulaglutide.Approved, Investigational
DuvelisibDuvelisib may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
DyphyllineThe serum concentration of Dyphylline can be increased when it is combined with Ciprofloxacin.Approved
E-6201E-6201 may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Ciprofloxacin.Approved
EliglustatCiprofloxacin may increase the QTc-prolonging activities of Eliglustat.Approved
EmpagliflozinCiprofloxacin may increase the hypoglycemic activities of Empagliflozin.Approved
EnalaprilThe risk or severity of ventricular arrhythmias can be increased when Enalapril is combined with Ciprofloxacin.Approved, Vet Approved
EnalaprilatThe risk or severity of ventricular arrhythmias can be increased when Enalaprilat is combined with Ciprofloxacin.Approved
EpirizoleEpirizole may increase the neuroexcitatory activities of Ciprofloxacin.Approved
EprosartanEprosartan may increase the arrhythmogenic activities of Ciprofloxacin.Approved
EquileninThe risk or severity of adverse effects can be increased when Equilenin is combined with Ciprofloxacin.Experimental
EquilinThe risk or severity of adverse effects can be increased when Equilin is combined with Ciprofloxacin.Approved
ErgonovineThe risk or severity of adverse effects can be increased when Ergonovine is combined with Ciprofloxacin.Approved
ErgotamineThe risk or severity of adverse effects can be increased when Ergotamine is combined with Ciprofloxacin.Approved
EribulinEribulin may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Ciprofloxacin.Approved, Investigational
ErythromycinErythromycin may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational, Vet Approved
EscitalopramCiprofloxacin may increase the QTc-prolonging activities of Escitalopram.Approved, Investigational
EstroneThe risk or severity of adverse effects can be increased when Estrone is combined with Ciprofloxacin.Approved
Estrone sulfateThe risk or severity of adverse effects can be increased when Estrone sulfate is combined with Ciprofloxacin.Approved
EtanerceptEtanercept may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
EthenzamideEthenzamide may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
Ethyl biscoumacetateCiprofloxacin may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EtodolacEtodolac may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
EtoricoxibEtoricoxib may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
Evening primrose oilEvening primrose oil may increase the neuroexcitatory activities of Ciprofloxacin.Investigational, Nutraceutical
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Ciprofloxacin.Approved
ExenatideCiprofloxacin may increase the hypoglycemic activities of Exenatide.Approved, Investigational
ExisulindExisulind may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
EzogabineEzogabine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
FamotidineFamotidine may increase the QTc-prolonging activities of Ciprofloxacin.Approved
FelbamateFelbamate may increase the QTc-prolonging activities of Ciprofloxacin.Approved
FelbinacFelbinac may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
FenbufenFenbufen may increase the neuroexcitatory activities of Ciprofloxacin.Approved
FenoprofenFenoprofen may increase the neuroexcitatory activities of Ciprofloxacin.Approved
FentiazacFentiazac may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
FeprazoneFeprazone may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
Ferric CarboxymaltoseThe serum concentration of Ciprofloxacin can be decreased when it is combined with Ferric Carboxymaltose.Approved
Ferric pyrophosphateThe serum concentration of Ciprofloxacin can be decreased when it is combined with Ferric pyrophosphate.Experimental
Ferulic acidFerulic acid may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
FimasartanFimasartan may increase the arrhythmogenic activities of Ciprofloxacin.Approved, Investigational
FingolimodFingolimod may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
FlecainideCiprofloxacin may increase the QTc-prolonging activities of Flecainide.Approved, Withdrawn
FloctafenineFloctafenine may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Withdrawn
FluasteroneThe risk or severity of adverse effects can be increased when Fluasterone is combined with Ciprofloxacin.Investigational
FluconazoleFluconazole may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
FludrocortisoneThe risk or severity of adverse effects can be increased when Fludrocortisone is combined with Ciprofloxacin.Approved, Investigational
FluindioneCiprofloxacin may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlumethasoneThe risk or severity of adverse effects can be increased when Flumethasone is combined with Ciprofloxacin.Approved, Vet Approved
FlunisolideThe risk or severity of adverse effects can be increased when Flunisolide is combined with Ciprofloxacin.Approved, Investigational
FlunixinFlunixin may increase the neuroexcitatory activities of Ciprofloxacin.Vet Approved
FlunoxaprofenFlunoxaprofen may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
Fluocinolone AcetonideThe risk or severity of adverse effects can be increased when Fluocinolone Acetonide is combined with Ciprofloxacin.Approved, Investigational, Vet Approved
FluocinonideThe risk or severity of adverse effects can be increased when Fluocinonide is combined with Ciprofloxacin.Approved, Investigational
FluocortoloneThe risk or severity of adverse effects can be increased when Fluocortolone is combined with Ciprofloxacin.Approved, Withdrawn
FluorometholoneThe risk or severity of adverse effects can be increased when Fluorometholone is combined with Ciprofloxacin.Approved, Investigational
FluoxetineCiprofloxacin may increase the QTc-prolonging activities of Fluoxetine.Approved, Vet Approved
FlupentixolCiprofloxacin may increase the QTc-prolonging activities of Flupentixol.Approved, Investigational, Withdrawn
FluprednideneThe risk or severity of adverse effects can be increased when Fluprednidene is combined with Ciprofloxacin.Approved, Withdrawn
FluprednisoloneThe risk or severity of adverse effects can be increased when Fluprednisolone is combined with Ciprofloxacin.Approved
FlurandrenolideThe risk or severity of adverse effects can be increased when Flurandrenolide is combined with Ciprofloxacin.Approved
FlurbiprofenFlurbiprofen may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
FluticasoneThe risk or severity of adverse effects can be increased when Fluticasone is combined with Ciprofloxacin.Approved, Experimental, Investigational
Fluticasone furoateThe risk or severity of adverse effects can be increased when Fluticasone furoate is combined with Ciprofloxacin.Approved
Fluticasone propionateThe risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Ciprofloxacin.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Ciprofloxacin.Approved
ForasartanForasartan may increase the arrhythmogenic activities of Ciprofloxacin.Experimental
FormestaneThe risk or severity of adverse effects can be increased when Formestane is combined with Ciprofloxacin.Approved, Investigational, Withdrawn
FormoterolFormoterol may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
FoscarnetFoscarnet may increase the QTc-prolonging activities of Ciprofloxacin.Approved
FosinoprilThe risk or severity of ventricular arrhythmias can be increased when Fosinopril is combined with Ciprofloxacin.Approved
FosphenytoinFosphenytoin may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
Gadobenic acidCiprofloxacin may increase the QTc-prolonging activities of Gadobenic acid.Approved, Investigational
GalantamineGalantamine may increase the QTc-prolonging activities of Ciprofloxacin.Approved
GemifloxacinCiprofloxacin may increase the QTc-prolonging activities of Gemifloxacin.Approved, Investigational
GitoformateGitoformate may decrease the cardiotoxic activities of Ciprofloxacin.Experimental
GliclazideCiprofloxacin may increase the hypoglycemic activities of Gliclazide.Approved
GlimepirideCiprofloxacin may increase the hypoglycemic activities of Glimepiride.Approved
GlipizideCiprofloxacin may increase the hypoglycemic activities of Glipizide.Approved, Investigational
GlyburideCiprofloxacin may increase the hypoglycemic activities of Glyburide.Approved
GoserelinGoserelin may increase the QTc-prolonging activities of Ciprofloxacin.Approved
GranisetronCiprofloxacin may increase the QTc-prolonging activities of Granisetron.Approved, Investigational
GuacetisalGuacetisal may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
HalcinonideThe risk or severity of adverse effects can be increased when Halcinonide is combined with Ciprofloxacin.Approved, Investigational, Withdrawn
HaloperidolHaloperidol may increase the QTc-prolonging activities of Ciprofloxacin.Approved
HE3286The risk or severity of adverse effects can be increased when HE3286 is combined with Ciprofloxacin.Investigational
HigenamineHigenamine may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
HistrelinHistrelin may increase the QTc-prolonging activities of Ciprofloxacin.Approved
HydrocortisoneThe risk or severity of adverse effects can be increased when Hydrocortisone is combined with Ciprofloxacin.Approved, Vet Approved
HydrotalciteHydrotalcite can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Experimental, Investigational
HydroxyzineHydroxyzine may increase the QTc-prolonging activities of Ciprofloxacin.Approved
IbandronateIbandronate may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Ciprofloxacin.Approved
IbuprofenIbuprofen may increase the neuroexcitatory activities of Ciprofloxacin.Approved
IbuproxamIbuproxam may increase the neuroexcitatory activities of Ciprofloxacin.Withdrawn
IbutilideCiprofloxacin may increase the QTc-prolonging activities of Ibutilide.Approved
IcatibantIcatibant may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
IloperidoneCiprofloxacin may increase the QTc-prolonging activities of Iloperidone.Approved
ImidaprilThe risk or severity of ventricular arrhythmias can be increased when Imidapril is combined with Ciprofloxacin.Investigational
Imidazole salicylateImidazole salicylate may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
ImipramineImipramine may increase the QTc-prolonging activities of Ciprofloxacin.Approved
IndacaterolIndacaterol may increase the QTc-prolonging activities of Ciprofloxacin.Approved
IndapamideIndapamide may increase the QTc-prolonging activities of Ciprofloxacin.Approved
IndobufenIndobufen may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
IndomethacinIndomethacin may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
IndoprofenIndoprofen may increase the neuroexcitatory activities of Ciprofloxacin.Withdrawn
Insulin AspartCiprofloxacin may increase the hypoglycemic activities of Insulin Aspart.Approved
Insulin DetemirCiprofloxacin may increase the hypoglycemic activities of Insulin Detemir.Approved
Insulin GlargineCiprofloxacin may increase the hypoglycemic activities of Insulin Glargine.Approved
Insulin GlulisineCiprofloxacin may increase the hypoglycemic activities of Insulin Glulisine.Approved
Insulin HumanCiprofloxacin may increase the hypoglycemic activities of Insulin Human.Approved, Investigational
Insulin LisproCiprofloxacin may increase the hypoglycemic activities of Insulin Lispro.Approved
IrbesartanIrbesartan may increase the arrhythmogenic activities of Ciprofloxacin.Approved, Investigational
IronThe serum concentration of Ciprofloxacin can be decreased when it is combined with Iron.Approved
Iron DextranThe serum concentration of Ciprofloxacin can be decreased when it is combined with Iron Dextran.Approved, Vet Approved
Iron saccharateThe serum concentration of Ciprofloxacin can be decreased when it is combined with Iron saccharate.Approved
IsavuconazoleThe serum concentration of Ciprofloxacin can be increased when it is combined with Isavuconazole.Approved, Investigational
IsofluraneIsoflurane may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Vet Approved
IsoxicamIsoxicam may increase the neuroexcitatory activities of Ciprofloxacin.Withdrawn
IsradipineIsradipine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
IstaroximeThe risk or severity of adverse effects can be increased when Istaroxime is combined with Ciprofloxacin.Investigational
ItraconazoleItraconazole may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
IvabradineIvabradine may increase the QTc-prolonging activities of Ciprofloxacin.Approved
KebuzoneKebuzone may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
KetoconazoleKetoconazole may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
KetoprofenKetoprofen may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Vet Approved
KetorolacKetorolac may increase the neuroexcitatory activities of Ciprofloxacin.Approved
Lanatoside CLanatoside C may decrease the cardiotoxic activities of Ciprofloxacin.Experimental
Lanthanum carbonateThe serum concentration of Ciprofloxacin can be decreased when it is combined with Lanthanum carbonate.Approved
LapatinibLapatinib may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Ciprofloxacin.Approved
LeflunomideLeflunomide may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
LenvatinibCiprofloxacin may increase the QTc-prolonging activities of Lenvatinib.Approved, Investigational
LeuprolideLeuprolide may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
LevofloxacinCiprofloxacin may increase the QTc-prolonging activities of Levofloxacin.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Ciprofloxacin.Approved
LiothyronineThe serum concentration of Liothyronine can be decreased when it is combined with Ciprofloxacin.Approved, Vet Approved
LiotrixThe serum concentration of Liotrix can be decreased when it is combined with Ciprofloxacin.Approved
LiraglutideCiprofloxacin may increase the hypoglycemic activities of Liraglutide.Approved
LisinoprilThe risk or severity of ventricular arrhythmias can be increased when Lisinopril is combined with Ciprofloxacin.Approved, Investigational
LisofyllineLisofylline may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
LisurideThe risk or severity of adverse effects can be increased when Lisuride is combined with Ciprofloxacin.Approved, Investigational
LithiumLithium may increase the QTc-prolonging activities of Ciprofloxacin.Approved
LonazolacLonazolac may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
LopinavirCiprofloxacin may increase the QTc-prolonging activities of Lopinavir.Approved
LornoxicamLornoxicam may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
LosartanLosartan may increase the arrhythmogenic activities of Ciprofloxacin.Approved
LoteprednolThe risk or severity of adverse effects can be increased when Loteprednol is combined with Ciprofloxacin.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Ciprofloxacin.Approved, Investigational
LoxoprofenLoxoprofen may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
LumacaftorThe serum concentration of Ciprofloxacin can be decreased when it is combined with Lumacaftor.Approved
LumefantrineCiprofloxacin may increase the QTc-prolonging activities of Lumefantrine.Approved
LumiracoxibLumiracoxib may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Ciprofloxacin.Illicit, Investigational, Withdrawn
MacimorelinCiprofloxacin may increase the QTc-prolonging activities of Macimorelin.Approved, Investigational
MagaldrateMagaldrate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Withdrawn
Magnesium carbonateMagnesium carbonate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Magnesium hydroxideMagnesium hydroxide can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Magnesium oxideMagnesium oxide can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium peroxideMagnesium peroxide can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
Magnesium salicylateThe serum concentration of Ciprofloxacin can be decreased when it is combined with Magnesium salicylate.Approved
Magnesium silicateMagnesium silicate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium sulfateThe serum concentration of Ciprofloxacin can be decreased when it is combined with Magnesium sulfate.Approved, Investigational, Vet Approved
Magnesium TrisilicateMagnesium Trisilicate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
MaprotilineMaprotiline may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
MasoprocolMasoprocol may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
ME-609The risk or severity of adverse effects can be increased when ME-609 is combined with Ciprofloxacin.Investigational
MecaserminCiprofloxacin may increase the hypoglycemic activities of Mecasermin.Approved, Investigational
Meclofenamic acidMeclofenamic acid may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Vet Approved
MedrysoneThe risk or severity of adverse effects can be increased when Medrysone is combined with Ciprofloxacin.Approved
Mefenamic acidMefenamic acid may increase the neuroexcitatory activities of Ciprofloxacin.Approved
MefloquineMefloquine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
MelengestrolThe risk or severity of adverse effects can be increased when Melengestrol is combined with Ciprofloxacin.Vet Approved
MeloxicamMeloxicam may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Vet Approved
MesalazineMesalazine may increase the neuroexcitatory activities of Ciprofloxacin.Approved
MetamizoleMetamizole may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational, Withdrawn
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Ciprofloxacin.Experimental
MetforminCiprofloxacin may increase the hypoglycemic activities of Metformin.Approved
MethadoneMethadone may increase the QTc-prolonging activities of Ciprofloxacin.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Ciprofloxacin.Approved
MethotrimeprazineMethotrimeprazine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
MethylergometrineThe risk or severity of adverse effects can be increased when Methylergometrine is combined with Ciprofloxacin.Approved
MethylprednisoloneThe risk or severity of adverse effects can be increased when Methylprednisolone is combined with Ciprofloxacin.Approved, Vet Approved
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Ciprofloxacin.Approved
MetildigoxinMetildigoxin may decrease the cardiotoxic activities of Ciprofloxacin.Experimental
MetoclopramideMetoclopramide may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
MetronidazoleMetronidazole may increase the QTc-prolonging activities of Ciprofloxacin.Approved
MevastatinThe serum concentration of Mevastatin can be increased when it is combined with Ciprofloxacin.Experimental
MifepristoneCiprofloxacin may increase the QTc-prolonging activities of Mifepristone.Approved, Investigational
MiglitolCiprofloxacin may increase the hypoglycemic activities of Miglitol.Approved
MirabegronMirabegron may increase the QTc-prolonging activities of Ciprofloxacin.Approved
MirtazapineMirtazapine may increase the QTc-prolonging activities of Ciprofloxacin.Approved
MizoribineMizoribine may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
MoexiprilThe risk or severity of ventricular arrhythmias can be increased when Moexipril is combined with Ciprofloxacin.Approved
MofebutazoneMofebutazone may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
MometasoneThe risk or severity of adverse effects can be increased when Mometasone is combined with Ciprofloxacin.Approved, Vet Approved
MoxifloxacinMoxifloxacin may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
Mycophenolate mofetilMycophenolate mofetil may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
Mycophenolic acidThe serum concentration of Mycophenolic acid can be decreased when it is combined with Ciprofloxacin.Approved
NabumetoneNabumetone may increase the neuroexcitatory activities of Ciprofloxacin.Approved
NafamostatNafamostat may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
NaftifineNaftifine may increase the neuroexcitatory activities of Ciprofloxacin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Ciprofloxacin.Approved
NaproxenNaproxen may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Vet Approved
NateglinideCiprofloxacin may increase the hypoglycemic activities of Nateglinide.Approved, Investigational
NCX 1022The risk or severity of adverse effects can be increased when NCX 1022 is combined with Ciprofloxacin.Investigational
NelfinavirNelfinavir may increase the QTc-prolonging activities of Ciprofloxacin.Approved
NepafenacNepafenac may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
NicardipineNicardipine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
NicergolineThe risk or severity of adverse effects can be increased when Nicergoline is combined with Ciprofloxacin.Approved, Investigational
NifenazoneNifenazone may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
Niflumic AcidNiflumic Acid may increase the neuroexcitatory activities of Ciprofloxacin.Approved
NilotinibCiprofloxacin may increase the QTc-prolonging activities of Nilotinib.Approved, Investigational
NimesulideNimesulide may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational, Withdrawn
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Ciprofloxacin.Approved
NitroaspirinNitroaspirin may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
NorfloxacinNorfloxacin may increase the QTc-prolonging activities of Ciprofloxacin.Approved
NortriptylineNortriptyline may increase the QTc-prolonging activities of Ciprofloxacin.Approved
OctreotideOctreotide may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
OfloxacinCiprofloxacin may increase the QTc-prolonging activities of Ofloxacin.Approved
OlanzapineOlanzapine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
OleandrinOleandrin may decrease the cardiotoxic activities of Ciprofloxacin.Experimental, Investigational
Oleoyl-estroneThe risk or severity of adverse effects can be increased when Oleoyl-estrone is combined with Ciprofloxacin.Investigational
OlmesartanOlmesartan may increase the arrhythmogenic activities of Ciprofloxacin.Approved, Investigational
OlodaterolOlodaterol may increase the QTc-prolonging activities of Ciprofloxacin.Approved
OlopatadineOlopatadine may increase the neuroexcitatory activities of Ciprofloxacin.Approved
OlsalazineOlsalazine may increase the neuroexcitatory activities of Ciprofloxacin.Approved
OmapatrilatThe risk or severity of ventricular arrhythmias can be increased when Omapatrilat is combined with Ciprofloxacin.Investigational
OndansetronCiprofloxacin may increase the QTc-prolonging activities of Ondansetron.Approved
OrgoteinOrgotein may increase the neuroexcitatory activities of Ciprofloxacin.Vet Approved
OuabainOuabain may decrease the cardiotoxic activities of Ciprofloxacin.Approved
OxaprozinOxaprozin may increase the neuroexcitatory activities of Ciprofloxacin.Approved
OxyphenbutazoneOxyphenbutazone may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Withdrawn
OxytocinOxytocin may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Vet Approved
PaclitaxelThe risk or severity of adverse effects can be increased when Paclitaxel is combined with Ciprofloxacin.Approved, Vet Approved
PaliperidoneCiprofloxacin may increase the QTc-prolonging activities of Paliperidone.Approved
PalmidrolPalmidrol may increase the neuroexcitatory activities of Ciprofloxacin.Experimental, Nutraceutical
PanobinostatCiprofloxacin may increase the QTc-prolonging activities of Panobinostat.Approved, Investigational
ParamethasoneThe risk or severity of adverse effects can be increased when Paramethasone is combined with Ciprofloxacin.Approved
ParecoxibParecoxib may increase the neuroexcitatory activities of Ciprofloxacin.Approved
ParoxetineParoxetine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
ParthenolideParthenolide may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
PasireotidePasireotide may increase the QTc-prolonging activities of Ciprofloxacin.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Ciprofloxacin.Approved
PentamidineCiprofloxacin may increase the QTc-prolonging activities of Pentamidine.Approved, Investigational
PerflutrenCiprofloxacin may increase the QTc-prolonging activities of Perflutren.Approved
PergolideThe risk or severity of adverse effects can be increased when Pergolide is combined with Ciprofloxacin.Approved, Investigational, Vet Approved, Withdrawn
PerindoprilThe risk or severity of ventricular arrhythmias can be increased when Perindopril is combined with Ciprofloxacin.Approved
PeruvosidePeruvoside may decrease the cardiotoxic activities of Ciprofloxacin.Experimental
PhenindioneCiprofloxacin may increase the anticoagulant activities of Phenindione.Approved, Investigational
PhenprocoumonCiprofloxacin may increase the anticoagulant activities of Phenprocoumon.Approved, Investigational
PhenylbutazonePhenylbutazone may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Vet Approved
PhenytoinThe therapeutic efficacy of Phenytoin can be decreased when used in combination with Ciprofloxacin.Approved, Vet Approved
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ciprofloxacin.Approved
PimecrolimusPimecrolimus may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
PimozideCiprofloxacin may increase the QTc-prolonging activities of Pimozide.Approved
PioglitazoneCiprofloxacin may increase the hypoglycemic activities of Pioglitazone.Approved, Investigational
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Ciprofloxacin.Approved, Investigational
PiroxicamPiroxicam may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
PirprofenPirprofen may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Ciprofloxacin.Approved
PitolisantThe risk or severity of QTc prolongation can be increased when Ciprofloxacin is combined with Pitolisant.Approved, Investigational
PosaconazolePosaconazole may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational, Vet Approved
PramlintideCiprofloxacin may increase the hypoglycemic activities of Pramlintide.Approved, Investigational
PranoprofenPranoprofen may increase the neuroexcitatory activities of Ciprofloxacin.Experimental, Investigational
PrasteroneThe risk or severity of adverse effects can be increased when Prasterone is combined with Ciprofloxacin.Approved, Investigational, Nutraceutical
Prasterone sulfateThe risk or severity of adverse effects can be increased when Prasterone sulfate is combined with Ciprofloxacin.Investigational
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Ciprofloxacin.Approved
PrednicarbateThe risk or severity of adverse effects can be increased when Prednicarbate is combined with Ciprofloxacin.Approved, Investigational
PrednisoloneThe risk or severity of adverse effects can be increased when Prednisolone is combined with Ciprofloxacin.Approved, Vet Approved
PrednisoneThe risk or severity of adverse effects can be increased when Prednisone is combined with Ciprofloxacin.Approved, Vet Approved
PregnenoloneThe risk or severity of adverse effects can be increased when Pregnenolone is combined with Ciprofloxacin.Approved, Experimental, Investigational
PrimaquineCiprofloxacin may increase the QTc-prolonging activities of Primaquine.Approved
ProbenecidThe serum concentration of Ciprofloxacin can be increased when it is combined with Probenecid.Approved, Investigational
ProcainamideCiprofloxacin may increase the QTc-prolonging activities of Procainamide.Approved
ProglumetacinProglumetacin may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
PromazinePromazine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Vet Approved
PromethazinePromethazine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
PropacetamolPropacetamol may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
PropafenoneCiprofloxacin may increase the QTc-prolonging activities of Propafenone.Approved
PropofolPropofol may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational, Vet Approved
PropyphenazonePropyphenazone may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
ProquazoneProquazone may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
ProscillaridinProscillaridin may decrease the cardiotoxic activities of Ciprofloxacin.Experimental
ProtriptylineProtriptyline may increase the QTc-prolonging activities of Ciprofloxacin.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Ciprofloxacin.Approved
PTC299PTC299 may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
QuetiapineCiprofloxacin may increase the QTc-prolonging activities of Quetiapine.Approved
QuinaprilQuinapril can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
QuinidineCiprofloxacin may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
QuinineCiprofloxacin may increase the QTc-prolonging activities of Quinine.Approved
RamiprilThe risk or severity of ventricular arrhythmias can be increased when Ramipril is combined with Ciprofloxacin.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Ciprofloxacin.Approved, Investigational
RepaglinideCiprofloxacin may increase the hypoglycemic activities of Repaglinide.Approved, Investigational
RescinnamineThe risk or severity of ventricular arrhythmias can be increased when Rescinnamine is combined with Ciprofloxacin.Approved
ResveratrolResveratrol may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Experimental, Investigational
RibociclibThe risk or severity of QTc prolongation can be increased when Ribociclib is combined with Ciprofloxacin.Approved, Investigational
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Ciprofloxacin.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Ciprofloxacin.Approved
RimexoloneThe risk or severity of adverse effects can be increased when Rimexolone is combined with Ciprofloxacin.Approved
RisperidoneRisperidone may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
RitonavirRitonavir may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
RofecoxibRofecoxib may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational, Withdrawn
RoflumilastThe serum concentration of Roflumilast can be increased when it is combined with Ciprofloxacin.Approved
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Ciprofloxacin.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Ciprofloxacin.Approved
RosiglitazoneCiprofloxacin may increase the hypoglycemic activities of Rosiglitazone.Approved, Investigational
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Ciprofloxacin.Approved
SacubitrilSacubitril may increase the arrhythmogenic activities of Ciprofloxacin.Approved
SalbutamolSalbutamol may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Vet Approved
SalicylamideSalicylamide may increase the neuroexcitatory activities of Ciprofloxacin.Approved
Salicylic acidSalicylic acid may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational, Vet Approved
SalmeterolSalmeterol may increase the QTc-prolonging activities of Ciprofloxacin.Approved
SalsalateSalsalate may increase the neuroexcitatory activities of Ciprofloxacin.Approved
SaprisartanSaprisartan may increase the arrhythmogenic activities of Ciprofloxacin.Experimental
SaquinavirCiprofloxacin may increase the QTc-prolonging activities of Saquinavir.Approved, Investigational
SaralasinSaralasin may increase the arrhythmogenic activities of Ciprofloxacin.Investigational
SaxagliptinCiprofloxacin may increase the hypoglycemic activities of Saxagliptin.Approved
SemapimodSemapimod may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
SeratrodastSeratrodast may increase the neuroexcitatory activities of Ciprofloxacin.Approved
SerrapeptaseSerrapeptase may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
SertralineSertraline may increase the QTc-prolonging activities of Ciprofloxacin.Approved
SevelamerSevelamer can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SevofluraneSevoflurane may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Vet Approved
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Ciprofloxacin.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Ciprofloxacin.Approved
SitagliptinCiprofloxacin may increase the hypoglycemic activities of Sitagliptin.Approved, Investigational
Sodium bicarbonateSodium bicarbonate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SolifenacinSolifenacin may increase the QTc-prolonging activities of Ciprofloxacin.Approved
SorafenibSorafenib may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
SotalolCiprofloxacin may increase the QTc-prolonging activities of Sotalol.Approved
SpiraprilThe risk or severity of ventricular arrhythmias can be increased when Spirapril is combined with Ciprofloxacin.Approved
SpironolactoneSpironolactone may increase the arrhythmogenic activities of Ciprofloxacin.Approved
SRT501SRT501 may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
Strontium ranelateThe serum concentration of Ciprofloxacin can be decreased when it is combined with Strontium ranelate.Approved, Withdrawn
SucralfateThe serum concentration of Ciprofloxacin can be decreased when it is combined with Sucralfate.Approved
SulfadiazineCiprofloxacin may increase the hypoglycemic activities of Sulfadiazine.Approved, Investigational, Vet Approved
SulfamethoxazoleSulfamethoxazole may increase the QTc-prolonging activities of Ciprofloxacin.Approved
SulfasalazineSulfasalazine may increase the neuroexcitatory activities of Ciprofloxacin.Approved
SulfisoxazoleSulfisoxazole may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Vet Approved
SulindacSulindac may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
SunitinibSunitinib may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
SuprofenSuprofen may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Withdrawn
SuxibuzoneSuxibuzone may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
TamoxifenTamoxifen may increase the QTc-prolonging activities of Ciprofloxacin.Approved
TarenflurbilTarenflurbil may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
TasosartanTasosartan may increase the arrhythmogenic activities of Ciprofloxacin.Approved
TelavancinCiprofloxacin may increase the QTc-prolonging activities of Telavancin.Approved
TelithromycinCiprofloxacin may increase the QTc-prolonging activities of Telithromycin.Approved
TelmisartanTelmisartan may increase the arrhythmogenic activities of Ciprofloxacin.Approved, Investigational
TemocaprilThe risk or severity of ventricular arrhythmias can be increased when Temocapril is combined with Ciprofloxacin.Experimental, Investigational
TenidapTenidap may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
TenoxicamTenoxicam may increase the neuroexcitatory activities of Ciprofloxacin.Approved
TepoxalinTepoxalin may increase the neuroexcitatory activities of Ciprofloxacin.Vet Approved
TerbutalineTerbutaline may increase the QTc-prolonging activities of Ciprofloxacin.Approved
TergurideThe risk or severity of adverse effects can be increased when Terguride is combined with Ciprofloxacin.Experimental
TeriflunomideTeriflunomide may increase the neuroexcitatory activities of Ciprofloxacin.Approved
TetrabenazineCiprofloxacin may increase the QTc-prolonging activities of Tetrabenazine.Approved, Investigational
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Ciprofloxacin.Approved
ThioridazineCiprofloxacin may increase the QTc-prolonging activities of Thioridazine.Approved, Withdrawn
ThiothixeneThiothixene may increase the QTc-prolonging activities of Ciprofloxacin.Approved
Thyroid, porcineThe serum concentration of Thyroid, porcine can be decreased when it is combined with Ciprofloxacin.Approved
Tiaprofenic acidTiaprofenic acid may increase the neuroexcitatory activities of Ciprofloxacin.Approved
TinoridineTinoridine may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
TioclomarolCiprofloxacin may increase the anticoagulant activities of Tioclomarol.Experimental
TixocortolThe risk or severity of adverse effects can be increased when Tixocortol is combined with Ciprofloxacin.Approved, Withdrawn
TizanidineTizanidine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
TolazamideCiprofloxacin may increase the hypoglycemic activities of Tolazamide.Approved, Investigational
TolbutamideCiprofloxacin may increase the hypoglycemic activities of Tolbutamide.Approved, Investigational
Tolfenamic AcidTolfenamic Acid may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
TolmetinTolmetin may increase the neuroexcitatory activities of Ciprofloxacin.Approved
TolterodineTolterodine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Ciprofloxacin.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Ciprofloxacin.Approved, Investigational
ToremifeneCiprofloxacin may increase the QTc-prolonging activities of Toremifene.Approved, Investigational
TrandolaprilThe risk or severity of ventricular arrhythmias can be increased when Trandolapril is combined with Ciprofloxacin.Approved
TranilastTranilast may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Ciprofloxacin.Approved, Investigational
TrazodoneTrazodone may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
TreprostinilTreprostinil may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
TriamcinoloneThe risk or severity of adverse effects can be increased when Triamcinolone is combined with Ciprofloxacin.Approved, Vet Approved
TribenosideTribenoside may increase the neuroexcitatory activities of Ciprofloxacin.Experimental
TrimethoprimTrimethoprim may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Vet Approved
TrimipramineTrimipramine may increase the QTc-prolonging activities of Ciprofloxacin.Approved
TriptolideTriptolide may increase the neuroexcitatory activities of Ciprofloxacin.Investigational
TriptorelinTriptorelin may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Vet Approved
TromethamineTromethamine can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
UlobetasolThe risk or severity of adverse effects can be increased when Ulobetasol is combined with Ciprofloxacin.Approved
ValdecoxibValdecoxib may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational, Withdrawn
ValsartanValsartan may increase the arrhythmogenic activities of Ciprofloxacin.Approved, Investigational
VandetanibCiprofloxacin may increase the QTc-prolonging activities of Vandetanib.Approved
VardenafilVardenafil may increase the QTc-prolonging activities of Ciprofloxacin.Approved
VareniclineThe serum concentration of Varenicline can be increased when it is combined with Ciprofloxacin.Approved, Investigational
VemurafenibThe risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Ciprofloxacin.Approved
VenlafaxineVenlafaxine may increase the QTc-prolonging activities of Ciprofloxacin.Approved
VilanterolVilanterol may increase the QTc-prolonging activities of Ciprofloxacin.Approved
VincristineThe excretion of Vincristine can be decreased when combined with Ciprofloxacin.Approved, Investigational
VoriconazoleVoriconazole may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
VorinostatVorinostat may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
WarfarinCiprofloxacin may increase the anticoagulant activities of Warfarin.Approved
XanthinolThe serum concentration of Xanthinol can be increased when it is combined with Ciprofloxacin.Approved, Withdrawn
ZaltoprofenZaltoprofen may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
ZileutonZileuton may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational, Withdrawn
ZiprasidoneCiprofloxacin may increase the QTc-prolonging activities of Ziprasidone.Approved
ZofenoprilThe risk or severity of ventricular arrhythmias can be increased when Zofenopril is combined with Ciprofloxacin.Experimental
ZomepiracZomepirac may increase the neuroexcitatory activities of Ciprofloxacin.Withdrawn
ZuclopenthixolCiprofloxacin may increase the QTc-prolonging activities of Zuclopenthixol.Approved, Investigational
Food Interactions
  • Avoid excessive quantities of coffee or tea (Caffeine).
  • Avoid milk, calcium containing dairy products, iron, magnesium, zinc, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
  • Take with a full glass of water.
  • Take without regard to meals.

References

Synthesis Reference
US4670444
General References
  1. Drusano GL, Standiford HC, Plaisance K, Forrest A, Leslie J, Caldwell J: Absolute oral bioavailability of ciprofloxacin. Antimicrob Agents Chemother. 1986 Sep;30(3):444-6. [PubMed:3777908]
  2. Hilliard JJ, Krause HM, Bernstein JI, Fernandez JA, Nguyen V, Ohemeng KA, Barrett JF: A comparison of active site binding of 4-quinolones and novel flavone gyrase inhibitors to DNA gyrase. Adv Exp Med Biol. 1995;390:59-69. [PubMed:8718602]
  3. Spivey JM, Cummings DM, Pierson NR: Failure of prostatitis treatment secondary to probable ciprofloxacin-sucralfate drug interaction. Pharmacotherapy. 1996 Mar-Apr;16(2):314-6. [PubMed:8820479]
  4. Brouwers JR: Drug interactions with quinolone antibacterials. Drug Saf. 1992 Jul-Aug;7(4):268-81. [PubMed:1524699]
External Links
Human Metabolome Database
HMDB0014677
KEGG Drug
D00186
KEGG Compound
C05349
PubChem Compound
2764
PubChem Substance
46504733
ChemSpider
2662
BindingDB
21690
ChEBI
100241
ChEMBL
CHEMBL8
Therapeutic Targets Database
DAP001360
PharmGKB
PA449009
HET
CPF
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Ciprofloxacin
ATC Codes
J01MA02 — CiprofloxacinJ01RA11 — Ciprofloxacin and tinidazoleS02AA15 — CiprofloxacinJ01RA12 — Ciprofloxacin and ornidazoleS03AA07 — CiprofloxacinS01AE03 — CiprofloxacinJ01RA10 — Ciprofloxacin and metronidazole
AHFS Codes
  • 52:04.04 — Antibacterials
  • 08:12.18 — Quinolones
PDB Entries
1oye / 1t9u / 2xct / 4bvv / 4kra / 5btc
FDA label
Download (120 KB)
MSDS
Download (73.9 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentAlcoholic Cirrhosis / Alcoholic Hepatitis (AH)1
0Enrolling by InvitationBasic ScienceDietary Modifications / Nutrition1
0Not Yet RecruitingTreatmentRhinoscleroma1
0RecruitingTreatmentOsteomyelitis1
1CompletedNot AvailableBacterial Infections / Brain Injury1
1CompletedNot AvailableDysbacteriosis1
1CompletedNot AvailableHealthy Volunteers3
1CompletedNot AvailableMetabolic Detoxication, Phase I1
1CompletedBasic ScienceHealthy Volunteers2
1CompletedOtherHealthy Volunteers / Non-Smokers1
1CompletedPreventionEscherichia Coli Infections1
1CompletedTreatmentBacillus Anthracis (Anthrax)1
1CompletedTreatmentBilateral Middle Ear Effusion Requiring Tympanostomy Tube Placement1
1CompletedTreatmentCystic Fibrosis (CF)2
1CompletedTreatmentHealthy Volunteers / Purpura, Thrombocytopaenic, Idiopathic / Purpura, Thrombocytopenic, Idiopathic1
1CompletedTreatmentHepatitis C Virus (HCV)1
1CompletedTreatmentInfection NOS / Pulmonary Disease, Chronic Obstructive1
1CompletedTreatmentPseudomonas Infections1
1CompletedTreatmentPulmonary Disease, Chronic Obstructive2
1CompletedTreatmentPulmonary Diseases1
1CompletedTreatmentRespiratory System1
1CompletedTreatmentUnspecified Adult Solid Tumor, Protocol Specific1
1RecruitingTreatmentConjunctivitis / Conjunctivitis, Bacterial1
1SuspendedTreatmentAnthrax1
1WithdrawnTreatmentHealthy Volunteers1
1WithdrawnTreatmentMalignant Lymphomas1
1, 2CompletedTreatmentEar Diseases / Otitis / Otitis Externa / Otorhinolaryngologic Diseases1
1, 2RecruitingTreatmentAcute Myelogenous Leukaemia (AML) / Leukemia Acute Myeloid Leukemia (AML) / Leukemias1
1, 2TerminatedTreatmentDiabetic Foot Ulcers (DFU)1
1, 2Unknown StatusPreventionHard of Hearing1
2Active Not RecruitingTreatmentChronic Lymphocytic Leukaemia (CLL)1
2CompletedPreventionCrohn's Disease (CD)1
2CompletedPreventionCystic Fibrosis (CF) / Pulmonary Disease, Chronic Obstructive1
2CompletedTreatmentAcute Otitis Media / AOMT1
2CompletedTreatmentAcute Bacterial Corneal Ulcers / Bacterial Keratitis1
2CompletedTreatmentAnthrax1
2CompletedTreatmentBronchiectasis1
2CompletedTreatmentCarcinoma of Head/Neck / Squamous Cell Carcinoma (SCC)1
2CompletedTreatmentCritical Illness / Hospital Acquired Infections / Pneumonia / Pyrexia / Systemic Inflammatory Response Syndrome (SIRS)1
2CompletedTreatmentCystic Fibrosis (CF)1
2CompletedTreatmentEar Diseases / Otitis / Otitis Externa / Otorhinolaryngologic Diseases2
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Infection, Mycobacterium Avium-Intracellulare1
2CompletedTreatmentNon-Cystic Fibrosis Bronchiectasis1
2CompletedTreatmentOtitis Externa1
2CompletedTreatmentPyelonephritis / Urinary Tract Infections (UTIs)1
2CompletedTreatmentUrinary Tract Infections (UTIs)1
2Not Yet RecruitingPreventionLeak, Anastomotic / Rectal Carcinoma1
2Not Yet RecruitingTreatmentCrohn's Disease (CD)1
2RecruitingPreventionProstate Infections1
2RecruitingTreatmentAdherent-invasive E. Coli / Crohn's Disease (CD)1
2RecruitingTreatmentCrohn's Disease (CD)2
2RecruitingTreatmentInfected Immature Permanent Teeth1
2TerminatedTreatmentAcute Otitis Media1
2TerminatedTreatmentCrohn's Disease (CD)1
2TerminatedTreatmentInfected Spacers / Prosthetic Joint Infections of Hip / Prosthetic Joint Infections of Knee1
2TerminatedTreatmentOsteomyelitis1
2Unknown StatusTreatmentPlague1
2WithdrawnDiagnosticProstate Cancer1
3Active Not RecruitingTreatmentBenign Lymphoepithelial Lesion / Human Immunodeficiency Virus (HIV) / Salivary Gland Diseases1
3Active Not RecruitingTreatmentTravelers' Diarrhea1
3CompletedNot AvailableAcute Otitis Media1
3CompletedPreventionBacterial Infections1
3CompletedSupportive CareInfection NOS / Multiple Myeloma (MM)1
3CompletedTreatmentAcute Otitis Externa1
3CompletedTreatmentAcute Otitis Externa / Swimmer's Ear1
3CompletedTreatmentAntibiotics / Chronic Obstructive Pulmonary Disease (COPD) / Sepsis1
3CompletedTreatmentBacterial Infections / Minor burns1
3CompletedTreatmentBronchiectasis1
3CompletedTreatmentCancer, Breast / Cyclophosphamide / Doxorubicin / High Risk / Positive Nodes1
3CompletedTreatmentCholera2
3CompletedTreatmentCrohn's Disease With Perianal Fistulas1
3CompletedTreatmentInfectious Diseases1
3CompletedTreatmentOtitis Externa1
3CompletedTreatmentOtitis Media (OM)1
3CompletedTreatmentPneumonia1
3CompletedTreatmentUrinary Tract Infections (UTIs)2
3Not Yet RecruitingTreatmentAntibiotic Resistant Infection / Complicated skin infection bacterial / Intra Abdominal Infections1
3Not Yet RecruitingTreatmentAntibiotic Resistant Infection / Urinary Tract Infections (UTIs)1
3Not Yet RecruitingTreatmentAntibiotic Resistant Infection / Complicated skin infection bacterial / Urinary Tract Infections (UTIs)1
3Not Yet RecruitingTreatmentChronic Rhinosinusitis (Diagnosis)1
3RecruitingTreatmentChronic Obstructive Pulmonary Disease (COPD)1
3RecruitingTreatmentEnterobacteriaceae Infections1
3RecruitingTreatmentKeratitis; Infectious Disease (Manifestation)1
3TerminatedPreventionMen Who Must Undergo a Prostate Biopsy Related to Prostate Cancer Suspicion1
3TerminatedPreventionUrolithiasis1
3TerminatedTreatmentAcute Otitis Externa1
3TerminatedTreatmentBladder Cancers1
3TerminatedTreatmentCancers / Fevers / Neutropenias1
3TerminatedTreatmentDiverticular Sigmoïditis1
3TerminatedTreatmentElevated Prostate Specific Antigen1
3TerminatedTreatmentOtitis Externa1
3TerminatedTreatmentOtitis Media in Patients With Tympanostomy Tubes1
3Unknown StatusSupportive CareBrain and Central Nervous System Tumors / Malignant Lymphomas / Neutropenias / Psychosocial Effects of Cancer and Its Treatment / Small Intestine Cancer / Unspecified Adult Solid Tumor, Protocol Specific1
3Unknown StatusTreatmentAcute Otitis Externa1
3Unknown StatusTreatmentNeutropenia, Febrile1
3WithdrawnPreventionSpontaneous Bacterial Peritonitis (SBP)1
4Active Not RecruitingTreatmentInfection NOS1
4CompletedNot AvailablePregnancy1
4CompletedPreventionAdverse Reaction to Other Drugs and Medicines1
4CompletedPreventionBacteriuria / Urinary Tract Infections (UTIs)1
4CompletedPreventionBenign Prostatic Hyperplasia (BPH)1
4CompletedPreventionMeningococcal Meningitis1
4CompletedPreventionUrinary Tract Infections (UTIs)1
4CompletedSupportive CareCancer, Breast1
4CompletedTreatmentCataracts1
4CompletedTreatmentChlamydia Trachomatis / Human Immunodeficiency Virus (HIV) / Neisseria Gonorrhoeae Infection1
4CompletedTreatmentChronic Periodontitis1
4CompletedTreatmentFevers / Urinary Tract Infections (UTIs)1
4CompletedTreatmentLiver Cirrhosis / SBP1
4CompletedTreatmentProstate Cancer1
4CompletedTreatmentPyelonephritis / Urinary Tract Infections (UTIs)1
4CompletedTreatmentUlcerative Colitis (UC)1
4CompletedTreatmentUncomplicated Bacterial Cystitis1
4CompletedTreatmentUrinary Tract Infections (UTIs)4
4Enrolling by InvitationTreatmentSmall Intestinal Bacterial Overgrowth1
4Not Yet RecruitingPreventionMeningococcal Meningitis1
4Not Yet RecruitingTreatmentOtitis Media (OM) / Otorrhoea1
4Not Yet RecruitingTreatmentOtitis Media With Effusion in Children / Otorrhoea1
4RecruitingOtherChronic Obstructive Pulmonary Disease (COPD) / Pseudomonas Aeruginosa / Respiratory Tract Infections (RTI)1
4RecruitingPreventionBK Virus Infection1
4RecruitingPreventionRenal Stones1
4RecruitingSupportive CarePancreatic Cystic Lesions1
4RecruitingTreatmentAntibiotic Resistant Infection / UTI - Lower Urinary Tract Infection1
4RecruitingTreatmentAsthma Bronchial1
4RecruitingTreatmentCritical Illness / Mechanical Ventilation Complication1
4RecruitingTreatmentEarly Stage Breast Cancer1
4RecruitingTreatmentUlcerative Colitis (UC)1
4SuspendedTreatmentGallstone formation1
4TerminatedDiagnosticProstate Infections1
4WithdrawnDiagnosticAscites / Infection NOS / Liver Cirrhosis1
Not AvailableActive Not RecruitingPreventionCatheter-Related Infections / Urinary Tract Infections (UTIs)1
Not AvailableActive Not RecruitingSupportive CareAscites (Non-Malignant) / Ascites Hepatic / Liver Cirrhosis1
Not AvailableCompletedNot AvailableAcute Cystitis1
Not AvailableCompletedNot AvailableBronchiectasis / Pulmonary Disease, Chronic Obstructive1
Not AvailableCompletedNot AvailableInfection NOS2
Not AvailableCompletedBasic ScienceEndotoxaemia1
Not AvailableCompletedBasic ScienceHealthy Volunteers / Sepsis1
Not AvailableCompletedPreventionPancreatic Cysts1
Not AvailableCompletedScreeningBacterial Resistance1
Not AvailableCompletedTreatmentAppendicitis / Children1
Not AvailableCompletedTreatmentCeftazidime / Ciprofloxacin / Pediatrics / Voriconazole1
Not AvailableCompletedTreatmentUlcerative Colitis (UC)1
Not AvailableCompletedTreatmentUrinary Tract Infections (UTIs)1
Not AvailableNot Yet RecruitingTreatmentProsthetic Joint Infection1
Not AvailableRecruitingNot AvailableAcute Bacterial Exacerbation of Chronic Bronchitis (ABECB) / Acute Bacterial Sinusitis (ABS) / Acute Decompensated Heart Failure (ADHF) / Acute Pyelonephritis / Adenovirus / Adjunct to general anesthesia therapy / Adrenal Insufficiency / Airway Swelling / Anaesthesia therapy / Anxiolysis / Arterial Hypotension / Autism, Early Infantile / Autistic Disorder / Bartonellosis / Benzodiazepine Withdrawal / Benzodiazepines / Bipolar Disorder (BD) / Bloodstream Infections / Bone and Joint Infections / Brain Swelling / Bronchospasm / Brucellosis / Cardiac Arrest / Central Nervous System Infections / Cholera / Chronic Bacterial Prostatitis / Community Acquired Pneumonia (CAP) / Complicated Urinary Tract Infections / Convulsions / Cyanide Poisoning / Cytomegalovirus Retinitis / Drug hypersensitivity reaction / Early-onset Schizophrenia Spectrum Disorders / Edema / Epilepsies / Feeling Anxious / Flu caused by Influenza / Gastroparesis / GYNAECOLOGICAL INFECTION / Headaches / Herpes Simplex Virus / High Blood Cholesterol Level / High Blood Pressure (Hypertension) / Hospital-acquired bacterial pneumonia / Hyperlipidemias / Infantile Hemangiomas / Infection NOS / Inflammatory Conditions / Inflammatory Reaction / Influenza Treatment or Prophylaxis / Inhalational Anthrax (Post-Exposure) / Intra-Abdominal Infections / Life-threatening Fungal Infections / Lower Respiratory Tract Infection (LRTI) / Meningitis, Bacterial / Migraines / Muscle Spasms / Nausea / Opioid Addiction / Pain / Plague / Pneumonia / Prophylaxis / Psittacosis / Q Fever / Reflux / Relapsing Fever / Rocky Mountain Spotted Fever / Schizophrenic Disorders / Sedation therapy / Seizures / Sepsis / Skeletal Muscle Spasms / Skin and Subcutaneous Tissue Bacterial Infections / Skin Structures and Soft Tissue Infections / Stable Angina (SA) / Thromboprophylaxis / Thrombosis / Trachoma / Treatment-resistant Schizophrenia / Tularemia / Typhus Fever / Uncomplicated Skin and Skin Structure Infections / Uncomplicated Urinary Tract Infections / Urinary Tract Infections (UTIs) / Vomiting / Withdrawal1
Not AvailableRecruitingNot AvailableCystitis / Pyelonephritis / Cystic Fibrosis / Anthrax1
Not AvailableRecruitingDiagnosticGonorrhoea1
Not AvailableRecruitingPreventionMotility Disorders / Staphylococcus Aureus1
Not AvailableRecruitingPreventionUrolithiasis / UTI1
Not AvailableRecruitingTreatmentBronchiectasis1
Not AvailableRecruitingTreatmentLiver Abscess, Pyogenic1
Not AvailableTerminatedSupportive CareChronic Myeloproliferative Disorders / Fever, Sweats, and Hot Flashes / Infection NOS / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms / Neutropenias / Precancerous Conditions / Unspecified Adult Solid Tumor, Protocol Specific1
Not AvailableTerminatedTreatmentClostridium Difficile / Prostate Cancer / Urinary Tract Infections (UTIs)1
Not AvailableTerminatedTreatmentHealthy Volunteers1
Not AvailableUnknown StatusTreatmentDiabetic Foot / Diabetic Foot Ulcers (DFU) / Osteomyelitis1
Not AvailableUnknown StatusTreatmentPeritonitis1

Pharmacoeconomics

Manufacturers
  • Bayer healthcare pharmaceuticals inc
  • Bayer pharmaceuticals corp
  • App pharmaceuticals llc
  • Bedford laboratories
  • Claris lifesciences ltd
  • Hospira inc
  • Teva parenteral medicines inc
  • West ward pharmaceutical corp
  • Hikma farmaceutica (portugal) sa
  • Acs dobfar info sa
  • Baxter healthcare corp
  • Bedford laboratories div ben venue laboratories inc
  • Alcon inc
  • Akorn inc
  • Bausch and lomb pharmaceuticals inc
  • Fdc ltd
  • Hitech pharmacal corp
  • Nexus pharmaceuticals inc
  • Novex pharma
  • Pharmaforce inc
  • Wraser pharmaceuticals llc
  • Depomed inc
  • Apotex inc
  • Aurobindo pharma ltd
  • Barr laboratories inc
  • Carlsbad technology inc
  • Dr reddys laboratories ltd
  • Hikma pharmaceuticals
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mylan pharmaceuticals inc
  • Nostrum laboratories inc
  • Pliva inc
  • Ranbaxy pharmaceuticals inc
  • Sandoz inc
  • Taro pharmaceuticals usa inc
  • Teva pharmaceuticals usa inc
  • Unique pharmaceutical laboratories
  • Watson laboratories inc
  • Allergan inc
Packagers
  • ACS Dobfar SPA
  • Actavis Group
  • Advanced Pharmaceutical Services Inc.
  • Aidarex Pharmacuticals LLC
  • Akorn Inc.
  • Alcon Laboratories
  • Allergan Inc.
  • Amerisource Health Services Corp.
  • Anchen Pharmaceuticals Inc.
  • Apotex Inc.
  • Apotheca Inc.
  • AQ Pharmaceuticals Inc.
  • Arrow Pharm Malta Ltd.
  • A-S Medication Solutions LLC
  • Aurobindo Pharma Ltd.
  • Barr Pharmaceuticals
  • Bausch & Lomb Inc.
  • Baxter International Inc.
  • Bayer Healthcare
  • Bedford Labs
  • Ben Venue Laboratories Inc.
  • Blenheim Pharmacal
  • Blu Pharmaceuticals LLC
  • Bryant Ranch Prepack
  • Cardinal Health
  • Carlsbad Technology Inc.
  • Claris Lifesciences Inc.
  • Cobalt Pharmaceuticals Inc.
  • Comprehensive Consultant Services Inc.
  • Core Pharmaceuticals
  • Daiichi Sankyo
  • Depomed Inc.
  • Dept Health Central Pharmacy
  • DHHS Program Support Center Supply Service Center
  • Direct Dispensing Inc.
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • Doctor Reddys Laboratories Ltd.
  • Dorx LLC
  • Esprit Pharma Inc.
  • Falcon Pharmaceuticals Ltd.
  • Forum Products Inc.
  • Golden State Medical Supply Inc.
  • Goldline Laboratories Inc.
  • H.J. Harkins Co. Inc.
  • Hi Tech Pharmacal Co. Inc.
  • Hikma Pharmaceuticals
  • Hospira Inc.
  • Indoco Remedies Limited
  • Innoviant Pharmacy Inc.
  • Ivax Pharmaceuticals
  • J.B. Chemicals & Pharmaceuticals
  • Kaiser Foundation Hospital
  • Keltman Pharmaceuticals Inc.
  • Kenyon Drug Co.
  • Lake Erie Medical and Surgical Supply
  • Lannett Co. Inc.
  • Legacy Pharmaceuticals Packaging LLC
  • Liberty Pharmaceuticals
  • Major Pharmaceuticals
  • Matrix Laboratories Ltd.
  • Mckesson Corp.
  • Medisca Inc.
  • Murfreesboro Pharmaceutical Nursing Supply
  • Mylan
  • Neuman Distributors Inc.
  • Nexus Pharmaceuticals
  • Northstar Rx LLC
  • Novartis AG
  • Novex Pharma
  • Nucare Pharmaceuticals Inc.
  • Pack Pharmaceuticals
  • Palmetto Pharmaceuticals Inc.
  • Par Pharmaceuticals
  • PCA LLC
  • PD-Rx Pharmaceuticals Inc.
  • Pfizer Inc.
  • Pharmaceutical Utilization Management Program VA Inc.
  • Pharmaforce Inc.
  • Pharmedix
  • Pharmpak Inc.
  • Physicians Total Care Inc.
  • Preferred Pharmaceuticals Inc.
  • Prepackage Specialists
  • Prepak Systems Inc.
  • Prescript Pharmaceuticals
  • Prescription Dispensing Service Inc.
  • Ranbaxy Laboratories
  • Rebel Distributors Corp.
  • Redpharm Drug
  • Remedy Repack
  • Sagent Pharmaceuticals
  • Sandhills Packaging Inc.
  • Sandoz
  • Schering Corp.
  • Southwood Pharmaceuticals
  • St Mary's Medical Park Pharmacy
  • Stat Rx Usa
  • Stat Scripts LLC
  • Taro Pharmaceuticals USA
  • Testpak Holding Company Inc.
  • Teva Pharmaceutical Industries Ltd.
  • Tya Pharmaceuticals
  • UDL Laboratories
  • West-Ward Pharmaceuticals
  • WraSer Pharmaceuticals
  • Yung Shin Pharmaceutical Industry Ltd.
Dosage forms
FormRouteStrength
OintmentOphthalmic0.3 %
OintmentOphthalmic3 mg/g
SolutionOphthalmic3.5 mg/mL
Kit
Solution, concentrateIntravenous2 mg/mL
SuspensionAuricular (otic)
LiquidIntravenous10 mg
SuspensionOral500 mg
TabletOral100 mg
Tablet, extended releaseOral1000 mg
Tablet, extended releaseOral500 mg
Suspension / dropsAuricular (otic)
InjectionIntravenous10 mg/mL
InjectionIntravenous2 mg/mL
Injection, solutionIntravenous2 mg/mL
Injection, solution, concentrateIntravenous10 mg/mL
Injection, solution, concentrateIntravenous200 mg/20mL
Injection, solution, concentrateIntravenous400 mg/40mL
Solution / dropsOphthalmic3 mg/mL
Solution / dropsOphthalmic3.5 mg/mL
Solution / dropsOphthalmic; Topical3 mg/mL
Solution / dropsTopical3 mg/mL
Solution / dropsTopical3.5 mg/1
Solution / dropsTopical3.5 mg/mL
TabletOral250 mg/1
TabletOral500 mg/1
TabletOral750 mg/1
Tablet, coatedOral500 mg/1
Tablet, film coatedOral100 mg/1
Tablet, film coatedOral250 mg/1
Tablet, film coatedOral500 mg/1
Tablet, film coatedOral750 mg/1
Tablet, film coated, extended releaseOral
SolutionOphthalmic3 mg/mL
SolutionIntravenous0.2 %
SolutionIntravenous10 mg
SolutionIntravenous2.0 mg
SolutionIntravenous2 mg
Solution / dropsAuricular (otic).5 mg/.25mL
SuspensionIntratympanic6 mg/mL
SolutionAuricular (otic)
For solutionAuricular (otic)
Tablet, film coated, extended releaseOral500 mg/1
SolutionOphthalmic0.3 %
TabletOral250 mg
TabletOral500 mg
TabletOral750 mg
Prices
Unit descriptionCostUnit
Cipro 400 mg Solution 40ml Vial259.99USD vial
Floxin Otic 0.3% Solution 10ml Bottle142.91USD bottle
Cipro 500 mg/5ml(10%) Suspension 100ml Bottle136.75USD bottle
Cipro HC 0.2-1% Suspension 10ml Bottle131.54USD bottle
Cipro 250 mg/5ml(5%) Suspension 100ml Bottle116.8USD bottle
Ocuflox 0.3% Solution 10ml Bottle106.09USD bottle
Ciprofloxacin HCl 0.3% Solution 10ml Bottle98.22USD bottle
Ciloxan 0.3% Ointment 3.5 gm Tube87.49USD tube
Floxin Otic 0.3% Solution 5ml Bottle86.49USD bottle
Ciloxan 0.3% Solution 5ml Bottle68.33USD bottle
Ocuflox 0.3% Solution 5ml Bottle57.32USD bottle
Ciprofloxacin HCl 0.3% Solution 5ml Bottle49.2USD bottle
ProQuin XR 3 500 mg 24 Hour tablet Disp Pack39.99USD disp
Ciprofloxacin HCl 0.3% Solution 2.5ml Bottle26.03USD bottle
Ciloxan 0.3% eye drops13.33USD ml
Ciprofloxacin 0.3% eye drop12.96USD ml
Cipro hc otic suspension12.65USD ml
Proquin xr 500 mg tablet12.18USD tablet
Cipro xr 1000 mg tablet11.91USD tablet
Ciprofloxacin-Ciproflox HCl 1000 mg 24 Hour tablet11.6USD tablet
Ocuflox 0.3% eye drops11.35USD ml
ProQuin XR 500 mg 24 Hour tablet11.18USD tablet
Ciprofloxacin er 1000 mg tablet11.16USD tablet
Cipro XR 500 mg 24 Hour tablet10.88USD tablet
Cipro XR 1000 mg 24 Hour tablet10.75USD tablet
Cipro xr 500 mg tablet10.46USD tablet
Ciprofloxacin-Ciproflox HCl 500 mg 24 Hour tablet10.19USD tablet
Ciprofloxacin er 500 mg tablet9.8USD tablet
Floxin 400 mg tablet9.55USD tablet
Cetraxal 0.2% ear solution7.14USD each
Floxin 200 mg tablet6.6USD tablet
Cipro 750 mg tablet6.26USD tablet
Cipro 500 mg tablet6.08USD tablet
Ciprofloxacin hcl 750 mg tablet5.65USD tablet
Floxin 300 mg tablet5.61USD tablet
Ciprofloxacin hcl 500 mg tablet5.59USD tablet
Cipro 250 mg tablet5.2USD tablet
Ciprofloxacin hcl 250 mg tablet4.59USD tablet
Floxin otic singles4.28USD each
Ciprofloxacin hcl 100 mg tablet4.17USD tablet
Ciloxan 0.3 % Solution2.18USD ml
Ciprofloxacin hcl powder1.29USD g
Apo-Ciproflox 0.3 % Solution1.18USD ml
Pms-Ciprofloxacin 0.3 % Solution1.18USD ml
Cipro i.v. 10 mg/ml vial0.72USD ml
Cipro i.v. 200 mg/100 ml d5w0.16USD ml
Ciprofloxacin 200 mg/20 ml vial0.13USD ml
Ciprofloxacn-d5w 200 mg/100 ml0.03USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5286754No1994-02-152011-02-15Us
CA2414271No2005-09-272021-06-13Canada
CA1330946No1994-07-262011-07-26Canada
US8187632Yes2001-12-232021-12-23Us
US7709022Yes2001-12-232021-12-23Us
US8846650No2005-06-042025-06-04Us
US9149486No2002-09-132022-09-13Us
US6359016No2000-08-102020-08-10Us
US6284804No2000-08-102020-08-10Us
US5972389No1996-09-192016-09-19Us
US6340475No1996-09-192016-09-19Us
US6635280No1996-09-192016-09-19Us
US6488962No2000-06-202020-06-20Us
US9205048No2009-04-212029-04-21Us
US8318817No2010-04-272030-04-27Us
US9220796No2015-07-012035-07-01Us
US9233068No2009-12-112029-12-11Us
US8932610No2010-03-242030-03-24Us
US9345714No2002-09-132022-09-13Us
US9402805No2002-09-132022-09-13Us
US9603796No2009-04-212029-04-21Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)255-257 °CNot Available
water solubility3E+004 mg/L (at 20 °C)NOWARA,A ET AL. (1997)
logP0.28TAKACS-NOVAK,K ET AL. (1992)
pKa6.09TORNIANEN,K ET AL. (1996)
Predicted Properties
PropertyValueSource
Water Solubility1.35 mg/mLALOGPS
logP-0.57ALOGPS
logP-0.81ChemAxon
logS-2.4ALOGPS
pKa (Strongest Acidic)5.76ChemAxon
pKa (Strongest Basic)8.68ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area72.88 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity87.94 m3·mol-1ChemAxon
Polarizability33.12 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-001i-0029000000-1366c290ed86c001f05b
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03dr-0069000000-a523751ea781088af897
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0009000000-f29d9954b2b055b62079
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-01qi-0039000000-9cb66ef0790c686ea2b2
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03di-0089000000-c501b014ce11307842e1
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0092000000-3f2bc2af8897693f406a
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0290000000-97cd08c23e39dd2412ec
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0690000000-c683e1591a42526bd85d
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0009000000-c8783567d83c0158dc21
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-01qi-0049000000-0c3e1fd26ebdc13a760e
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03di-0079000000-84eeb4205e8a902133ec
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0192000000-3bebeb08e817739aa5f7
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0290000000-40a5de8dd981d46dbe88
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0690000000-827770181ddec7977048
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03dr-0079000000-b9937740f37fc8a939a6
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-001i-0009000000-06b6d10cecb7c9cab240
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-001i-0129000000-61453c8af95773ec6b29
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-03dr-0296000000-de128c8d0e1eade700b6
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0gx1-1292000000-2d8ff05ee839372800db
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-001i-1290000000-f3446636040c80d0f8a3
LC-MS/MS Spectrum - LC-ESI-IT , positiveLC-MS/MSsplash10-000i-0090000000-6fc954ec7c93eaabef55
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001j-0198000000-0bfdea918825b34619d5
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0090000000-5cee2f47095630088ff6
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-01p9-0095000000-c780444ec059d2f2f98e
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-01p9-0095000000-1dc83645e6c6c47ab02f
MS/MS Spectrum - , positiveLC-MS/MSsplash10-014i-0920000000-9769fb468772887a192f
MS/MS Spectrum - , positiveLC-MS/MSsplash10-001i-0397000000-0e08dc88a42e413750ce

Taxonomy

Description
This compound belongs to the class of organic compounds known as quinoline carboxylic acids. These are quinolines in which the quinoline ring system is substituted by a carboxyl group at one or more positions.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Quinolines and derivatives
Sub Class
Quinoline carboxylic acids
Direct Parent
Quinoline carboxylic acids
Alternative Parents
Fluoroquinolones / N-arylpiperazines / Haloquinolines / Hydroquinolones / Aminoquinolines and derivatives / Hydroquinolines / Pyridinecarboxylic acids / Dialkylarylamines / Benzenoids / Aryl fluorides
show 12 more
Substituents
Quinoline-3-carboxylic acid / Fluoroquinolone / N-arylpiperazine / Aminoquinoline / Haloquinoline / Dihydroquinolone / Dihydroquinoline / Pyridine carboxylic acid / Pyridine carboxylic acid or derivatives / Tertiary aliphatic/aromatic amine
show 29 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
N-arylpiperazine, aminoquinoline, quinolone antibiotic, fluoroquinolone antibiotic, quinolone, quinolinemonocarboxylic acid (CHEBI:100241)

Targets

Kind
Protein
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Pharmacological action
Yes
Actions
Inhibitor
General Function
Dna topoisomerase type ii (atp-hydrolyzing) activity
Specific Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Gene Name
parC
Uniprot ID
P43702
Uniprot Name
DNA topoisomerase 4 subunit A
Molecular Weight
83366.24 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Chaudhry U, Ray K, Bala M, Saluja D: Mutation patterns in gyrA and parC genes of ciprofloxacin resistant isolates of Neisseria gonorrhoeae from India. Sex Transm Infect. 2002 Dec;78(6):440-4. [PubMed:12473806]
  4. Lee JK, Lee YS, Park YK, Kim BS: Mutations in the gyrA and parC genes in ciprofloxacin-resistant clinical isolates of Acinetobacter baumannii in Korea. Microbiol Immunol. 2005;49(7):647-53. [PubMed:16034208]
  5. Leavis HL, Willems RJ, Top J, Bonten MJ: High-level ciprofloxacin resistance from point mutations in gyrA and parC confined to global hospital-adapted clonal lineage CC17 of Enterococcus faecium. J Clin Microbiol. 2006 Mar;44(3):1059-64. [PubMed:16517894]
  6. Drlica K, Zhao X: DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. [PubMed:9293187]
Kind
Protein
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Pharmacological action
Yes
Actions
Inhibitor
General Function
Dna topoisomerase type ii (atp-hydrolyzing) activity
Specific Function
DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, inc...
Gene Name
gyrA
Uniprot ID
P43700
Uniprot Name
DNA gyrase subunit A
Molecular Weight
97817.145 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Chaudhry U, Ray K, Bala M, Saluja D: Mutation patterns in gyrA and parC genes of ciprofloxacin resistant isolates of Neisseria gonorrhoeae from India. Sex Transm Infect. 2002 Dec;78(6):440-4. [PubMed:12473806]
  4. Abdelbaqi K, Menard A, Prouzet-Mauleon V, Bringaud F, Lehours P, Megraud F: Nucleotide sequence of the gyrA gene of Arcobacter species and characterization of human ciprofloxacin-resistant clinical isolates. FEMS Immunol Med Microbiol. 2007 Apr;49(3):337-45. [PubMed:17378897]
  5. Taylor DE, Chau AS: Cloning and nucleotide sequence of the gyrA gene from Campylobacter fetus subsp. fetus ATCC 27374 and characterization of ciprofloxacin-resistant laboratory and clinical isolates. Antimicrob Agents Chemother. 1997 Mar;41(3):665-71. [PubMed:9056011]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Ubiquitin binding
Specific Function
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segr...
Gene Name
TOP2A
Uniprot ID
P11388
Uniprot Name
DNA topoisomerase 2-alpha
Molecular Weight
174383.88 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  2. Robinson MJ, Martin BA, Gootz TD, McGuirk PR, Osheroff N: Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group. Antimicrob Agents Chemother. 1992 Apr;36(4):751-6. [PubMed:1323952]
  3. Hussy P, Maass G, Tummler B, Grosse F, Schomburg U: Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother. 1986 Jun;29(6):1073-8. [PubMed:3015015]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Specific Function
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the ...
Gene Name
KCNH2
Uniprot ID
Q12809
Uniprot Name
Potassium voltage-gated channel subfamily H member 2
Molecular Weight
126653.52 Da
References
  1. Keseru GM: Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2773-5. [PubMed:12873512]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Identical protein binding
Specific Function
DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, inc...
Gene Name
gyrA
Uniprot ID
P0AES4
Uniprot Name
DNA gyrase subunit A
Molecular Weight
96962.63 Da
References
  1. Hubschwerlen C, Specklin JL, Baeschlin DK, Borer Y, Haefeli S, Sigwalt C, Schroeder S, Locher HH: Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4229-33. [PubMed:14623007]
Kind
Protein
Organism
Staphylococcus aureus
Pharmacological action
Unknown
General Function
Dna topoisomerase type ii (atp-hydrolyzing) activity
Specific Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Gene Name
parC
Uniprot ID
P0C1U9
Uniprot Name
DNA topoisomerase 4 subunit A
Molecular Weight
91040.465 Da
References
  1. Wiles JA, Song Y, Wang Q, Lucien E, Hashimoto A, Cheng J, Marlor CW, Ou Y, Podos SD, Thanassi JA, Thoma CL, Deshpande M, Pucci MJ, Bradbury BJ: Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1277-81. Epub 2005 Dec 7. [PubMed:16337789]
Kind
Protein
Organism
Bacillus subtilis (strain 168)
Pharmacological action
Unknown
General Function
Magnesium ion binding
Specific Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Gene Name
parE
Uniprot ID
Q59192
Uniprot Name
DNA topoisomerase 4 subunit B
Molecular Weight
73006.17 Da
References
  1. Butler MM, Lamarr WA, Foster KA, Barnes MH, Skow DJ, Lyden PT, Kustigian LM, Zhi C, Brown NC, Wright GE, Bowlin TL: Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound. Antimicrob Agents Chemother. 2007 Jan;51(1):119-27. Epub 2006 Oct 30. [PubMed:17074800]
Kind
Protein
Organism
Bacillus subtilis (strain 168)
Pharmacological action
Unknown
General Function
Dna topoisomerase type ii (atp-hydrolyzing) activity
Specific Function
DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, inc...
Gene Name
gyrA
Uniprot ID
P05653
Uniprot Name
DNA gyrase subunit A
Molecular Weight
92098.19 Da
References
  1. Butler MM, Lamarr WA, Foster KA, Barnes MH, Skow DJ, Lyden PT, Kustigian LM, Zhi C, Brown NC, Wright GE, Bowlin TL: Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound. Antimicrob Agents Chemother. 2007 Jan;51(1):119-27. Epub 2006 Oct 30. [PubMed:17074800]
Kind
Protein
Organism
Escherichia coli
Pharmacological action
Unknown
General Function
Drug transmembrane transporter activity
Specific Function
Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.
Gene Name
mdtK
Uniprot ID
C3T8E2
Uniprot Name
Multidrug resistance protein MdtK
Molecular Weight
49446.52 Da
References
  1. Long F, Rouquette-Loughlin C, Shafer WM, Yu EW: Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Antimicrob Agents Chemother. 2008 Sep;52(9):3052-60. doi: 10.1128/AAC.00475-08. Epub 2008 Jun 30. [PubMed:18591276]
Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
Unknown
General Function
Dna topoisomerase type ii (atp-hydrolyzing) activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
B4YQT9
Uniprot Name
Gyrase A
Molecular Weight
17024.015 Da
References
  1. Karkare S, Chung TT, Collin F, Mitchenall LA, McKay AR, Greive SJ, Meyer JJ, Lall N, Maxwell A: The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. J Biol Chem. 2013 Feb 15;288(7):5149-56. doi: 10.1074/jbc.M112.419069. Epub 2012 Dec 28. [PubMed:23275348]
Kind
Protein
Organism
Staphylococcus aureus
Pharmacological action
Unknown
General Function
Dna topoisomerase type ii (atp-hydrolyzing) activity
Specific Function
DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, inc...
Gene Name
gyrA
Uniprot ID
P20831
Uniprot Name
DNA gyrase subunit A
Molecular Weight
99620.34 Da
References
  1. Surivet JP, Zumbrunn C, Rueedi G, Hubschwerlen C, Bur D, Bruyere T, Locher H, Ritz D, Keck W, Seiler P, Kohl C, Gauvin JC, Mirre A, Kaegi V, Dos Santos M, Gaertner M, Delers J, Enderlin-Paput M, Boehme M: Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity. J Med Chem. 2013 Sep 26;56(18):7396-415. doi: 10.1021/jm400963y. Epub 2013 Sep 11. [PubMed:23968485]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
  3. Drug Interactions & Labeling - FDA [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
  2. Drug Interactions & Labeling - FDA [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
  2. Drug Interactions & Labeling - FDA [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
  3. Drug Interactions & Labeling - FDA [Link]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol. 2001 Dec;14(12):1596-603. [PubMed:11743742]
  2. Yamaguchi H, Yano I, Saito H, Inui K: Effect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rats. Pharm Res. 2004 Feb;21(2):330-8. [PubMed:15032316]

Drug created on June 13, 2005 07:24 / Updated on June 24, 2018 20:22