Patent Ductus Arteriosus (PDA)

Also known as: Patent Ductus Arteriosus / Ductus Arteriosus Patent / Ductus Arteriosus, Patent / PDA / Patent arterial duct / Patent ductus Botallo / Patent ductus arteriosis

DrugDrug NameDrug Description
DB00770AlprostadilA medication used to treat erectile dysfunction.
DB01050IbuprofenAn NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation.
DB00328IndomethacinA nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants.
DrugDrug NameTargetType
DB00770AlprostadilProstaglandin E2 receptor EP2 subtypetarget
DB00770AlprostadilProstaglandin E2 receptor EP1 subtypetarget
DB00770AlprostadilMultidrug resistance-associated protein 5transporter
DB00770AlprostadilSolute carrier organic anion transporter family member 2B1transporter
DB00770AlprostadilSolute carrier organic anion transporter family member 3A1transporter
DB00770AlprostadilMultidrug resistance-associated protein 4transporter
DB00770AlprostadilSolute carrier organic anion transporter family member 2A1transporter
DB00770AlprostadilProstaglandin D2 receptor 2target
DB00770AlprostadilSolute carrier family 22 member 6transporter
DB01050IbuprofenProstaglandin G/H synthase 1target
DB01050IbuprofenProstaglandin G/H synthase 2target
DB01050IbuprofenCytochrome P450 2C9enzyme
DB01050IbuprofenSerum albumincarrier
DB01050IbuprofenMultidrug resistance-associated protein 4transporter
DB01050IbuprofenMultidrug resistance-associated protein 1transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 1A2transporter
DB01050IbuprofenSolute carrier family 22 member 6transporter
DB01050IbuprofenSolute carrier family 22 member 8transporter
DB01050IbuprofenSolute carrier family 22 member 11transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 2B1transporter
DB01050IbuprofenP-glycoprotein 1transporter
DB01050IbuprofenUDP-glucuronosyltransferase 1-3enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 1-9enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B4enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B7enzyme
DB01050IbuprofenCytochrome P450 2C8enzyme
DB01050IbuprofenCytochrome P450 2C19enzyme
DB01050IbuprofenApoptosis regulator Bcl-2target
DB01050IbuprofenThrombomodulintarget
DB01050IbuprofenFatty acid-binding protein, intestinaltarget
DB01050IbuprofenPeroxisome proliferator-activated receptor gammatarget
DB01050IbuprofenCystic fibrosis transmembrane conductance regulatortarget
DB01050IbuprofenPeroxisome proliferator-activated receptor alphatarget
DB01050IbuprofenPlatelet glycoprotein Ib alpha chaintarget
DB01050IbuprofenProtein S100-A7target
DB01050IbuprofenAlpha-methylacyl-CoA racemaseenzyme
DB01050IbuprofenCytochrome P450 3A4enzyme
DB00328IndomethacinProstaglandin G/H synthase 1target
DB00328IndomethacinProstaglandin G/H synthase 2target
DB00328IndomethacinCytochrome P450 2C19enzyme
DB00328IndomethacinUDP-glucuronosyltransferase 1-9enzyme
DB00328IndomethacinPhospholipase A2, membrane associatedtarget
DB00328IndomethacinProstaglandin reductase 2target
DB00328IndomethacinLactoylglutathione lyasetarget
DB00328IndomethacinProstaglandin D2 receptor 2target
DB00328IndomethacinPeroxisome proliferator-activated receptor gammatarget
DB00328IndomethacinSerum albumincarrier
DB00328IndomethacinCanalicular multispecific organic anion transporter 2transporter
DB00328IndomethacinMultidrug resistance-associated protein 4transporter
DB00328IndomethacinMultidrug resistance-associated protein 6transporter
DB00328IndomethacinP-glycoprotein 1transporter
DB00328IndomethacinMultidrug resistance-associated protein 1transporter
DB00328IndomethacinSolute carrier organic anion transporter family member 1A2transporter
DB00328IndomethacinSolute carrier family 22 member 6transporter
DB00328IndomethacinSolute carrier family 22 member 8transporter
DB00328IndomethacinCanalicular multispecific organic anion transporter 1transporter
DB00328IndomethacinATP-binding cassette sub-family C member 11transporter
DB00328IndomethacinSolute carrier family 22 member 11transporter
DB00328IndomethacinSodium/bile acid cotransportertransporter
DB00328IndomethacinSolute carrier family 22 member 7transporter
DB00328IndomethacinCytochrome P450 2C9enzyme
DB00328IndomethacinUDP-glucuronosyltransferase 1-1enzyme
DB00328IndomethacinLiver carboxylesterase 1enzyme
DB00328IndomethacinUDP-glucuronosyltransferase 2B7enzyme
DB00328IndomethacinPeroxisome proliferator-activated receptor alphatarget
DB00328IndomethacinAldo-keto reductase family 1 member C3target
DB00328IndomethacinSolute carrier organic anion transporter family member 1B1transporter
DB00328IndomethacinBile salt export pumptransporter
DrugDrug NamePhaseStatusCount
DB00316Acetaminophen1Completed1
DB00316Acetaminophen1Recruiting1
DB01050Ibuprofen1Completed1
DB01050Ibuprofen1Recruiting1
DB09153Sodium chloride1Recruiting1
DB01050Ibuprofen1 / 2Unknown Status1
DB00316Acetaminophen2Active Not Recruiting1
DB00316Acetaminophen2Completed1
DB00316Acetaminophen2Not Yet Recruiting1
DB00316Acetaminophen2Recruiting1
DB00316Acetaminophen2Unknown Status1
DB01050Ibuprofen2Completed1
DB01050Ibuprofen2Not Yet Recruiting1
DB01050Ibuprofen2Recruiting1
DB01050Ibuprofen2Withdrawn1
DB00328Indomethacin2Completed1
DB00328Indomethacin2Unknown Status1
DB00328Indomethacin2Withdrawn1
DB00806Pentoxifylline2Unknown Status1
DB00316Acetaminophen2 / 3Not Yet Recruiting1
DB00316Acetaminophen2 / 3Recruiting1
DB00316Acetaminophen2 / 3Suspended1
DB00800Fenoldopam2 / 3Recruiting1
DB01050Ibuprofen2 / 3Completed1
DB01050Ibuprofen2 / 3Recruiting1
DB01050Ibuprofen2 / 3Suspended1
DB00328Indomethacin2 / 3Terminated1
DB00316Acetaminophen3Completed1
DB00316Acetaminophen3Recruiting1
DB00316Acetaminophen3Terminated1
DB11874Crocin3Completed1
DB01050Ibuprofen3Completed5
DB01050Ibuprofen3Recruiting1
DB00328Indomethacin3Completed3
DB00328Indomethacin3Terminated1
DB00123L-Lysine3Completed1
DB00316Acetaminophen4Active Not Recruiting1
DB00316Acetaminophen4Completed1
DB00316Acetaminophen4Unknown Status1
DB06761Beractant4Terminated1
DB01050Ibuprofen4Active Not Recruiting1
DB01050Ibuprofen4Completed4
DB01050Ibuprofen4Terminated1
DB01050Ibuprofen4Unknown Status1
DB01050Ibuprofen4Withdrawn1
DB00328Indomethacin4Completed1
DB00328Indomethacin4Withdrawn1
DB09113Poractant alfa4Terminated1
DB00316AcetaminophenNot AvailableCompleted1
DB00316AcetaminophenNot AvailableRecruiting2
DB01050IbuprofenNot AvailableCompleted4
DB01050IbuprofenNot AvailableRecruiting2
DB01050IbuprofenNot AvailableTerminated3
DB00328IndomethacinNot AvailableRecruiting1
DB00328IndomethacinNot AvailableTerminated1