Identification
NameIbuprofen
Accession NumberDB01050  (APRD00372)
TypeSmall Molecule
GroupsApproved
Description

Ibuprofen, a propionic acid derivative, is a prototypical nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.

Structure
Thumb
Synonyms
(±)-2-(p-isobutylphenyl)propionic acid
(±)-ibuprofen
(±)-p-isobutylhydratropic acid
(±)-α-methyl-4-(2-methylpropyl)benzeneacetic acid
(4-isobutylphenyl)-α-methylacetic acid
(RS)-ibuprofen
2-(4-isobutylphenyl)propanoic acid
4-isobutylhydratropic acid
Ibuprophen
α-(4-isobutylphenyl)propionic acid
α-(p-isobutylphenyl)propionic acid
External IDs Not Available
Product Ingredients
IngredientUNIICASInChI KeyDetails
Ibuprofen aluminumD0YGZ1VO1B 61054-06-6QAZIXAUMDFPQRW-UHFFFAOYSA-KDetails
Ibuprofen lysineN01ORX9D6S 57469-77-9IHHXIUAEPKVVII-ZSCHJXSPSA-NDetails
Ibuprofen potassium48304089JJ 79261-49-7XJELUCTZEAQYGF-UHFFFAOYSA-MDetails
Ibuprofen sodiumRM1CE97Z4N 527688-20-6VTGPMVCGAVZLQI-UHFFFAOYSA-MDetails
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alti-ibuprofen Tab 600mgTablet600 mgOralAltimed Pharma Inc.1984-12-311999-09-17Canada
CaldolorSolution100 mgIntravenousAlveda Pharmaceuticals Inc2012-06-15Not applicableCanada
CaldolorInjection800 mg/8mLIntravenousCumberland Pharmaceuticals2009-06-11Not applicableUs
Ibuprofen LysineSolution10 mg/mLIntravenousPrasco, Laboratories2016-04-14Not applicableUs
Ibuprofen-600 Tab 600mgTablet600 mgOralPro Doc Limitee1986-12-312014-07-24Canada
Motrin Tablets 600mgTablet600 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1980-12-312004-07-22Canada
NeoprofenSolution10 mg/mLIntravenousRecordati Rare Diseases Inc2006-04-13Not applicableUs
Novo-profenTablet600 mgOralTeva1985-12-31Not applicableCanada
Nu-ibuprofen Tab 600mgTablet600 mgOralNu Pharm Inc1993-12-312012-09-04Canada
PedeaInjection, solution5 mg/mlIntravenousOrphan Europe S.A.R.L.2004-07-29Not applicableEu
PMS-ibuprofenTablet600 mgOralPharmascience Inc2008-07-09Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AlivioTablet400 mg/400mgOralAlivio Medical Products, Llc2015-07-01Not applicableUs
AlivioTablet600 mg/600mgOralAlivio Medical Products, Llc2015-07-01Not applicableUs
AlivioTablet800 mg/800mgOralAlivio Medical Products, Llc2015-07-01Not applicableUs
Apo Ibuprofen Tab 600mgTablet600 mgOralApotex Corporation1984-12-31Not applicableCanada
Comfort Pac With IbuprofenKitPd Rx Pharmaceuticals, Inc.2012-09-06Not applicableUs
IbuTablet800 mg/1OralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2009-06-172017-04-15Us
IbuTablet600 mg/1OralGolden State Medical Supply2014-04-22Not applicableUs
IbuTablet600 mg/1OralUnit Dose Services2008-11-20Not applicableUs
IbuTablet800 mg/1OralDr Reddy's Laboratories2008-11-20Not applicableUs
IbuTablet400 mg/1OralNucare Pharmaceuticals, Inc.2008-11-20Not applicableUs
IbuTablet800 mg/1OralNucare Pharmaceuticals, Inc.2008-11-20Not applicableUs
IbuTablet400 mg/1OralCardinal Health2009-07-20Not applicableUs
IbuTablet600 mg/1OralProficient Rx LP2008-11-20Not applicableUs
IbuTablet800 mg/1OralBlenheim Pharmacal, Inc.2012-03-23Not applicableUs
IbuTablet800 mg/1OralUnit Dose Services2008-11-20Not applicableUs
IbuTablet400 mg/1OralUnit Dose Services2008-11-20Not applicableUs
IbuTablet600 mg/1OralRed Pharm Drug, Inc.2008-11-20Not applicableUs
IbuTablet400 mg/1OralBlenheim Pharmacal, Inc.2014-01-14Not applicableUs
IbuTablet800 mg/1OralKaiser Foundations Hospitals2012-06-05Not applicableUs
IbuTablet600 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2008-11-20Not applicableUs
IbuTablet600 mg/1OralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2009-07-092017-04-15Us
IbuTablet400 mg/1OralDr Reddy's Laboratories2008-11-20Not applicableUs
IbuTablet400 mg/1Oralbryant ranch prepack2008-11-20Not applicableUs
IbuTablet400 mg/1OralRed Pharm Drug, Inc.2008-11-20Not applicableUs
IbuTablet800 mg/1OralGolden State Medical Supply2014-04-22Not applicableUs
IbuTablet800 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2010-10-19Not applicableUs
IbuTablet600 mg/1OralNucare Pharmaceuticals, Inc.2008-11-20Not applicableUs
IbuTablet400 mg/1OralNu Care Pharmaceuticals,inc.2008-11-20Not applicableUs
IbuTablet400 mg/1OralGolden State Medical Supply2014-04-22Not applicableUs
IbuTablet600 mg/1OralDr Reddy's Laboratories2008-11-20Not applicableUs
IbuTablet800 mg/1OralCardinal Health2009-06-17Not applicableUs
IbuTablet800 mg/1OralDirectrx2015-12-29Not applicableUs
IbuTablet400 mg/1OralNucare Pharmaceuticals, Inc.2008-11-20Not applicableUs
IbuTablet600 mg/1OralNu Care Pharmaceuticals,inc.2008-11-20Not applicableUs
IbuTablet400 mg/1OralUnit Dose Services2008-11-20Not applicableUs
IbuTablet800 mg/1OralRed Pharm Drug, Inc.2008-11-20Not applicableUs
IbuTablet600 mg/1OralKaiser Foundations Hospitals2012-05-09Not applicableUs
IbuTablet400 mg/1OralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2009-07-202017-04-15Us
IbuprofenTablet600 mg/1OralRebel Distributors2009-11-23Not applicableUs
IbuprofenTablet, film coated800 mg/1OralPolygen Pharmaceuticals Inc.2011-11-28Not applicableUs
IbuprofenTablet400 mg/1OralPreferreed Pharmaceuticals Inc.2012-09-28Not applicableUs
IbuprofenTablet400 mg/1OralDispensing Solutions, Inc.2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralA S Medication Solutions2009-11-232017-06-20Us
IbuprofenTablet, film coated800 mg/1OralA S Medication Solutions2015-12-212017-06-20Us
IbuprofenTablet400 mg/1OralAscend Laboratories, LLC2009-02-06Not applicableUs
IbuprofenTablet400 mg/1OralCardinal Health2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralMethod Pharmaceuticals2017-04-15Not applicableUs
IbuprofenTablet600 mg/1OralBlenheim Pharmacal, Inc.2014-02-04Not applicableUs
IbuprofenSuspension100 mg/5mLOralPharmaceutical Associates, Inc.2004-09-23Not applicableUs
IbuprofenTablet600 mg/1OralLegacy Pharmaceutical Packaging2011-02-28Not applicableUs
IbuprofenSuspension100 mg/5mLOralStat Rx USA2004-12-08Not applicableUs
IbuprofenTablet400 mg/1OralMc Kesson Contract Packaging2012-01-05Not applicableUs
IbuprofenTablet600 mg/1OralRxchange Co2014-11-09Not applicableUs
IbuprofenTablet800 mg/1Oralbryant ranch prepack2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2012-02-22Not applicableUs
IbuprofenTablet400 mg/1OralMed Vantx, Inc.2009-11-23Not applicableUs
IbuprofenTablet, film coated800 mg/800mgOralWestminster2016-03-282016-10-13Us
IbuprofenTablet800 1/1OralContract Pharmacy Services Pa2010-04-14Not applicableUs
IbuprofenTablet400 mg/1OralProficient Rx LP2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralAmerincan Health Packaging2013-10-14Not applicableUs
IbuprofenTablet600 mg/1OralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
IbuprofenTablet, film coated800 mg/1OralUnit Dose Services2015-12-21Not applicableUs
IbuprofenTablet400 mg/1OralMajor2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralRemedy Repack2011-07-122016-10-28Us
IbuprofenTablet, film coated400 mg/1OralRemedy Repack2016-10-19Not applicableUs
IbuprofenTablet600 mg/1OralAmerincan Health Packaging2011-03-232015-12-29Us
IbuprofenTablet600 mg/1OralA S Medication Solutions2012-02-222017-06-20Us
IbuprofenTablet, film coated800 mg/1OralRemedy Repack2016-11-17Not applicableUs
IbuprofenTablet600 mg/1OralBi Coastal Pharma International Llc2016-04-14Not applicableUs
IbuprofenTablet800 mg/1OralNorthwind Pharmaceuticals2014-06-01Not applicableUs
IbuprofenTablet400 mg/1OralAmneal Pharmaceuticals of New York Llc2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralRemedy Repack2014-06-052017-02-16Us
IbuprofenTablet400 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
IbuprofenTablet600 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2011-11-21Not applicableUs
IbuprofenTablet800 mg/1OralPreferreed Pharmaceuticals Inc.2008-11-20Not applicableUs
IbuprofenTablet600 mg/1OralPhysicians Total Care, Inc.1997-05-08Not applicableUs
IbuprofenTablet600 mg/1OralBlenheim Pharmacal, Inc.2010-09-15Not applicableUs
IbuprofenTablet600 mg/1OralRemedy Repack2011-04-212016-10-13Us
IbuprofenTablet, film coated800 mg/1OralLegacy Pharmaceutical Packaging2015-09-21Not applicableUs
IbuprofenTablet800 mg/1OralBlenheim Pharmacal, Inc.2015-06-03Not applicableUs
IbuprofenTablet400 mg/1OralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
IbuprofenSuspension100 mg/5mLOralPerrigo New York Inc.2004-12-08Not applicableUs
IbuprofenTablet600 mg/1OralA S Medication Solutions2009-11-232017-06-20Us
IbuprofenSuspension100 mg/5mLOralRebel Distributors2004-09-23Not applicableUs
IbuprofenTablet600 mg/1OralDirectrx2015-01-01Not applicableUs
IbuprofenTablet, film coated800 mg/1OralMed Pharma Co., Ltd.2012-10-01Not applicableUs
IbuprofenTablet, film coated600 mg/1OralCardinal Health2009-06-10Not applicableUs
IbuprofenTablet600 mg/1OralAphena Pharma Solutions Tennessee, Inc.2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralBlenheim Pharmacal, Inc.2010-09-08Not applicableUs
IbuprofenTablet800 mg/1OralLife Line Home Care Services2012-02-13Not applicableUs
IbuprofenTablet, film coated400 mg/1OralTime Cap Laboratories2015-12-30Not applicableUs
IbuprofenTablet800 mg/1OralCardinal Health2013-10-14Not applicableUs
IbuprofenTablet600 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2012-02-22Not applicableUs
IbuprofenTablet800 mg/1OralA S Medication Solutions2009-11-232017-06-20Us
IbuprofenTablet800 mg/1OralClinical Solutions Wholsesale2009-11-232017-06-20Us
IbuprofenTablet, film coated600 mg/600mgOralWestminster2016-03-282016-10-13Us
IbuprofenTablet600 mg/1OralRemedy Repack2013-05-302017-01-04Us
IbuprofenTablet800 mg/1OralRemedy Repack2017-01-03Not applicableUs
IbuprofenTablet800 mg/1OralProficient Rx LP2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
IbuprofenTablet800 mg/1OralUnit Dose Services2012-02-22Not applicableUs
IbuprofenTablet600 mg/1OralRemedy Repack2011-07-082016-10-26Us
IbuprofenTablet400 mg/1OralHHS/Program Support Center/Supply Service Center2009-11-23Not applicableUs
IbuprofenTablet, film coated800 mg/1OralA S Medication Solutions2015-12-212017-06-20Us
IbuprofenTablet600 mg/1OralA S Medication Solutions2012-02-222017-06-20Us
IbuprofenTablet, film coated800 mg/1OralDirectrx2014-01-01Not applicableUs
IbuprofenTablet600 mg/1OralMARKSANS PHARMA LIMITED2011-02-28Not applicableUs
IbuprofenTablet, film coated800 mg/1OralGranules India Limited2015-09-21Not applicableUs
IbuprofenTablet600 mg/1OralNorthwind Pharmaceuticals2014-08-14Not applicableUs
IbuprofenSuspension100 mg/5mLOralLake Erie Medical Dba Quality Care Produts Llc2004-12-08Not applicableUs
IbuprofenTablet400 mg/1OralAv Kare, Inc.2013-01-10Not applicableUs
IbuprofenTablet800 mg/1OralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralH.J. Harkins Company2009-11-23Not applicableUs
IbuprofenTablet, film coated800 mg/1OralRemedy Repack2017-01-25Not applicableUs
IbuprofenTablet600 mg/1OralContract Pharmacy Services Pa2010-04-14Not applicableUs
IbuprofenTablet400 mg/1OralPhysicians Total Care, Inc.1997-02-20Not applicableUs
IbuprofenTablet400 mg/1OralAscend Laboratories, LLC2012-02-22Not applicableUs
IbuprofenTablet600 mg/1OralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
IbuprofenTablet, coated600 mg/1OralBiomes Pharmaceuticals2009-05-02Not applicableUs
IbuprofenTablet, film coated800 mg/1OralRebel Distributors2009-06-10Not applicableUs
IbuprofenTablet, film coated200 mg/1OralRemedy Repack2015-02-132017-03-16Us
IbuprofenTablet600 mg/1OralQualitest2009-11-232015-12-29Us
IbuprofenTablet, film coated400 mg/1OralMajor2009-06-10Not applicableUs
IbuprofenTablet800 mg/1OralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralDispensing Solutions, Inc.2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralApotheca, Inc.2008-11-20Not applicableUs
IbuprofenTablet400 mg/1OralRed Pharm Drug, Inc.2009-11-23Not applicableUs
IbuprofenTablet, film coated600 mg/1OralAscend Laboratories, LLC2015-12-21Not applicableUs
IbuprofenTablet400 mg/1OralLegacy Pharmaceutical Packaging2011-02-28Not applicableUs
IbuprofenTablet, film coated600 mg/1OralStat Rx USA2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
IbuprofenTablet600 mg/1OralContract Pharmacy Services Pa2009-09-22Not applicableUs
IbuprofenTablet400 mg/1OralAmerincan Health Packaging2013-10-14Not applicableUs
IbuprofenTablet600 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-11-23Not applicableUs
IbuprofenTablet, film coated600 mg/1OralAmneal Pharmaceuticals of New York Llc2014-04-01Not applicableUs
IbuprofenTablet400 mg/1OralCardinal Health2009-11-232015-12-29Us
IbuprofenTablet400 mg/1OralRemedy Repack2013-09-192017-09-19Us
IbuprofenTablet400 mg/1OralPreferreed Pharmaceuticals Inc.2008-11-20Not applicableUs
IbuprofenTablet600 mg/1OralRemedy Repack2010-11-232016-10-25Us
IbuprofenTablet, film coated400 mg/1OralLegacy Pharmaceutical Packaging2015-09-21Not applicableUs
IbuprofenTablet400 mg/1OralA S Medication Solutions2009-11-232017-06-20Us
IbuprofenTablet600 mg/1OralIngenus Pharmaceuticals Llc2015-10-02Not applicableUs
IbuprofenTablet, film coated600 mg/1OralAi Ping Pharmaceutical, Inc.2016-11-23Not applicableUs
IbuprofenTablet, film coated400 mg/1OralPolygen Pharmaceuticals Inc.2011-11-28Not applicableUs
IbuprofenTablet600 mg/1OralPreferreed Pharmaceuticals Inc.2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralA S Medication Solutions2009-11-232017-06-20Us
IbuprofenTablet800 mg/1OralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
IbuprofenSuspension100 mg/5mLOralCardinal Health2012-08-16Not applicableUs
IbuprofenTablet, film coated800 mg/1OralDenton Pharma, Inc.2017-04-04Not applicableUs
IbuprofenTablet400 mg/1OralBlenheim Pharmacal, Inc.2010-03-10Not applicableUs
IbuprofenTablet600 mg/1OralStat Rx USA2008-11-20Not applicableUs
IbuprofenTablet800 mg/1OralGolden State Medical Supply2009-11-23Not applicableUs
IbuprofenTablet, film coated400 mg/1OralA S Medication Solutions2015-12-21Not applicableUs
IbuprofenTablet800 mg/1OralAidarex Pharmaceuticals LLC2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralRemedy Repack2011-04-212016-10-13Us
IbuprofenTablet, film coated800 mg/1OralUnit Dose Services2015-12-21Not applicableUs
IbuprofenTablet600 mg/1OralA S Medication Solutions2009-11-232017-06-20Us
IbuprofenTablet, film coated400 mg/1OralDirectrx2014-01-01Not applicableUs
IbuprofenTablet800 mg/1OralRemedy Repack2013-04-032016-03-12Us
IbuprofenTablet, film coated400 mg/1OralGranules India Limited2015-09-21Not applicableUs
IbuprofenTablet, film coated600 mg/1OralNorthwind Pharmaceuticals2014-10-28Not applicableUs
IbuprofenTablet, film coated800 mg/1OralCardinal Health2009-06-10Not applicableUs
IbuprofenTablet800 mg/1OralRebel Distributors2009-11-23Not applicableUs
IbuprofenTablet400 mg/1OralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2009-11-23Not applicableUs
IbuprofenTablet400 mg/1OralH.J. Harkins Company2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralPreferreed Pharmaceuticals Inc.2012-09-28Not applicableUs
IbuprofenTablet600 mg/1OralDispensing Solutions, Inc.2009-11-23Not applicableUs
IbuprofenTablet400 mg/1OralA S Medication Solutions2009-11-232017-06-20Us
IbuprofenTablet, film coated800 mg/1OralA S Medication Solutions2015-12-212017-06-20Us
IbuprofenTablet600 mg/1OralAscend Laboratories, LLC2009-02-06Not applicableUs
IbuprofenTablet800 mg/1OralCardinal Health2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralMethod Pharmaceuticals2017-04-15Not applicableUs
IbuprofenTablet800 mg/1OralBlenheim Pharmacal, Inc.2014-02-04Not applicableUs
IbuprofenTablet, film coated800 mg/1OralKaiser Foundations Hospitals2009-11-30Not applicableUs
IbuprofenTablet800 mg/1OralLegacy Pharmaceutical Packaging2011-02-28Not applicableUs
IbuprofenTablet, film coated400 mg/1OralRebel Distributors2009-06-10Not applicableUs
IbuprofenTablet600 mg/1OralMc Kesson Contract Packaging2011-12-22Not applicableUs
IbuprofenTablet800 mg/1OralRxchange Co2009-11-23Not applicableUs
IbuprofenTablet400 mg/1Oralbryant ranch prepack2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralNorthwind Pharmaceuticals2015-11-04Not applicableUs
IbuprofenTablet400 mg/1OralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralMed Vantx, Inc.2009-11-23Not applicableUs
IbuprofenTablet400 mg/1OralApotheca, Inc.1991-02-11Not applicableUs
IbuprofenTablet800 mg/1OralRed Pharm Drug, Inc.2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralProficient Rx LP2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralKeltman Pharmaceuticals Inc.2007-08-24Not applicableUs
IbuprofenTablet400 mg/1OralAphena Pharma Solutions Tennessee, Inc.2009-11-23Not applicableUs
IbuprofenTablet, film coated800 mg/1OralRemedy Repack2016-07-28Not applicableUs
IbuprofenTablet600 mg/1OralMajor2009-11-23Not applicableUs
IbuprofenTablet400 mg/1OralRemedy Repack2011-08-112016-11-05Us
IbuprofenTablet, film coated600 mg/1OralRemedy Repack2016-10-24Not applicableUs
IbuprofenTablet800 mg/1OralAmerincan Health Packaging2011-03-242015-12-29Us
IbuprofenTablet600 mg/1OralA S Medication Solutions2012-02-222017-06-20Us
IbuprofenTablet400 mg/1OralClinical Solutions Wholsesale2009-11-232017-06-24Us
IbuprofenTablet800 mg/1OralBi Coastal Pharma International Llc2016-04-14Not applicableUs
IbuprofenTablet400 mg/1OralRemedy Repack2013-02-112017-01-25Us
IbuprofenTablet600 mg/1OralAmneal Pharmaceuticals of New York Llc2009-11-23Not applicableUs
IbuprofenTablet400 mg/1OralRemedy Repack2015-12-24Not applicableUs
IbuprofenTablet, film coated400 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
IbuprofenTablet400 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2011-11-21Not applicableUs
IbuprofenTablet, film coated800 mg/1OralAphena Pharma Solutions Tennessee, Inc.2009-06-10Not applicableUs
IbuprofenTablet800 mg/1OralPhysicians Total Care, Inc.1994-12-20Not applicableUs
IbuprofenTablet800 mg/1OralUnit Dose Services2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralBlenheim Pharmacal, Inc.2010-11-03Not applicableUs
IbuprofenTablet, film coated800 mg/1OralAscend Laboratories, LLC2015-12-21Not applicableUs
IbuprofenTablet800 mg/1OralMesource Pharmaceuticals2009-11-23Not applicableUs
IbuprofenTablet, film coated600 mg/1OralTime Cap Laboratories2015-12-30Not applicableUs
IbuprofenTablet, film coated600 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2015-12-21Not applicableUs
IbuprofenTablet800 mg/1OralA S Medication Solutions2009-11-232017-06-20Us
IbuprofenSuspension100 mg/5mLOralHi Tech Pharmacal Co., Inc.2016-11-28Not applicableUs
IbuprofenTablet, film coated600 mg/1OralRemedy Repack2013-07-162016-12-30Us
IbuprofenTablet, film coated400 mg/1OralRemedy Repack2017-01-19Not applicableUs
IbuprofenTablet, film coated600 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
IbuprofenTablet400 mg/1OralA S Medication Solutions2009-11-232017-06-20Us
IbuprofenTablet600 mg/1OralCardinal Health2011-03-23Not applicableUs
IbuprofenTablet800 mg/1OralBlenheim Pharmacal, Inc.2012-08-23Not applicableUs
IbuprofenTablet200 mg/1OralApotheca, Inc.2014-02-14Not applicableUs
IbuprofenTablet400 mg/1OralGolden State Medical Supply2009-11-23Not applicableUs
IbuprofenTablet, film coated400 mg/1OralA S Medication Solutions2015-12-212017-06-20Us
IbuprofenTablet800 mg/1OralMARKSANS PHARMA LIMITED2011-02-28Not applicableUs
IbuprofenTablet600 mg/1OralProficient Rx LP2012-02-22Not applicableUs
IbuprofenTablet600 mg/1OralAv Kare, Inc.2013-01-10Not applicableUs
IbuprofenTablet400 mg/1OralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
IbuprofenTablet400 mg/1OralContract Pharmacy Services Pa2010-04-12Not applicableUs
IbuprofenTablet600 mg/1OralAscend Laboratories, LLC2012-02-22Not applicableUs
IbuprofenSuspension100 mg/5mLOralActavis Pharma Company2002-09-27Not applicableUs
IbuprofenTablet, coated800 mg/1OralBiomes Pharmaceuticals2009-05-02Not applicableUs
IbuprofenTablet800 mg/1OralQualitest2009-11-232015-12-29Us
IbuprofenTablet, film coated600 mg/1OralMajor2009-06-10Not applicableUs
IbuprofenTablet600 mg/1OralBlenheim Pharmacal, Inc.2010-04-28Not applicableUs
IbuprofenTablet800 mg/1OralStat Rx USA2008-11-20Not applicableUs
IbuprofenTablet400 mg/1OralAidarex Pharmaceuticals LLC2009-11-23Not applicableUs
IbuprofenTablet600 mg/1Oralbryant ranch prepack2009-11-23Not applicableUs
IbuprofenTablet, film coated800 mg/1OralStat Rx USA2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralTYA Pharmaceuticals2009-11-23Not applicableUs
IbuprofenTablet800 1/1OralContract Pharmacy Services Pa2009-10-01Not applicableUs
IbuprofenTablet600 mg/1OralAmerincan Health Packaging2013-10-14Not applicableUs
IbuprofenTablet800 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-11-23Not applicableUs
IbuprofenTablet, film coated800 mg/1OralAmneal Pharmaceuticals of New York Llc2014-04-01Not applicableUs
IbuprofenTablet400 mg/1OralAmerincan Health Packaging2011-03-232015-12-29Us
IbuprofenTablet400 mg/1OralBi Coastal Pharma International Llc2016-04-14Not applicableUs
IbuprofenTablet600 mg/1OralRemedy Repack2013-11-112017-10-12Us
IbuprofenTablet600 mg/1OralPreferreed Pharmaceuticals Inc.2008-11-20Not applicableUs
IbuprofenTablet400 mg/1OralRemedy Repack2011-04-182016-10-13Us
IbuprofenTablet, film coated600 mg/1OralLegacy Pharmaceutical Packaging2015-09-21Not applicableUs
IbuprofenTablet400 mg/1OralA S Medication Solutions2009-11-232017-06-20Us
IbuprofenTablet800 mg/1OralIngenus Pharmaceuticals Llc2015-10-02Not applicableUs
IbuprofenTablet, film coated800 mg/1OralAi Ping Pharmaceutical, Inc.2016-11-23Not applicableUs
IbuprofenTablet, film coated600 mg/1OralPolygen Pharmaceuticals Inc.2011-11-28Not applicableUs
IbuprofenTablet800 mg/1OralPreferreed Pharmaceuticals Inc.2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralA S Medication Solutions2009-11-232017-06-20Us
IbuprofenTablet, film coated600 mg/1OralPreferreed Pharmaceuticals Inc.2017-02-22Not applicableUs
IbuprofenTablet400 mg/1OralMethod Pharmaceuticals2017-04-15Not applicableUs
IbuprofenTablet, film coated400 mg/400mgOralWestminster2016-03-282016-10-13Us
IbuprofenTablet800 mg/1OralRemedy Repack2013-05-132017-01-18Us
IbuprofenTablet800 mg/1OralAmneal Pharmaceuticals of New York Llc2009-11-23Not applicableUs
IbuprofenTablet, film coated800 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
IbuprofenSuspension100 mg/5mLOralA S Medication Solutions2004-12-082017-06-20Us
IbuprofenTablet600 mg/1OralDispensing Solutions, Inc.2009-11-23Not applicableUs
IbuprofenTablet400 mg/1OralBlenheim Pharmacal, Inc.2010-12-20Not applicableUs
IbuprofenTablet400 mg/1OralRemedy Repack2011-04-262016-10-13Us
IbuprofenTablet800 mg/1OralPerrigo International2006-05-08Not applicableUs
IbuprofenTablet400 mg/1OralRemedy Repack2017-05-15Not applicableUs
IbuprofenTablet600 mg/1OralA S Medication Solutions2009-11-232017-06-20Us
IbuprofenTablet, film coated600 mg/1OralDirectrx2014-01-01Not applicableUs
IbuprofenTablet400 mg/1OralMARKSANS PHARMA LIMITED2011-02-28Not applicableUs
IbuprofenTablet, film coated600 mg/1OralGranules India Limited2015-09-21Not applicableUs
IbuprofenTablet, film coated400 mg/301OralNorthwind Pharmaceuticals2014-05-20Not applicableUs
IbuprofenTablet, film coated400 mg/1OralCardinal Health2009-06-10Not applicableUs
IbuprofenTablet400 mg/1OralRebel Distributors2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralH.J. Harkins Company2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralPreferreed Pharmaceuticals Inc.2012-09-28Not applicableUs
IbuprofenSuspension100 mg/5mLOralVista Pharm, Inc.2012-08-16Not applicableUs
IbuprofenTablet600 mg/1OralA S Medication Solutions2009-11-232017-06-20Us
IbuprofenTablet, film coated600 mg/1OralA S Medication Solutions2015-12-212017-06-20Us
IbuprofenTablet800 mg/1OralAscend Laboratories, LLC2009-02-06Not applicableUs
IbuprofenTablet800 mg/1OralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralBlenheim Pharmacal, Inc.2010-05-17Not applicableUs
IbuprofenTablet, coated400 mg/1OralBiomes Pharmaceuticals2009-05-02Not applicableUs
IbuprofenTablet, film coated600 mg/1OralRebel Distributors2009-06-10Not applicableUs
IbuprofenTablet400 mg/1OralSt. Marys Medical Park Pharmacy2013-07-11Not applicableUs
IbuprofenTablet400 mg/1OralQualitest2009-11-232015-12-29Us
IbuprofenTablet800 mg/1OralLake Erie Medical &Surgical Supply Dba Quality Care Products Llc2009-11-23Not applicableUs
IbuprofenTablet200 mg/1OralRemedy Repack2010-12-082015-12-29Us
IbuprofenTablet600 mg/1OralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralMed Vantx, Inc.2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralApotheca, Inc.1996-12-23Not applicableUs
IbuprofenTablet800 mg/1OralRed Pharm Drug, Inc.2009-11-23Not applicableUs
IbuprofenTablet, film coated400 mg/1OralAscend Laboratories, LLC2015-12-21Not applicableUs
IbuprofenTablet800 mg/1OralKeltman Pharmaceuticals Inc.2007-08-24Not applicableUs
IbuprofenTablet800 mg/1OralAphena Pharma Solutions Tennessee, Inc.2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralRemedy Repack2016-10-12Not applicableUs
IbuprofenTablet800 mg/1OralMajor2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralRemedy Repack2011-03-112016-12-10Us
IbuprofenTablet600 mg/1OralCardinal Health2013-10-14Not applicableUs
IbuprofenTablet800 mg/1OralA S Medication Solutions2009-11-232017-06-20Us
IbuprofenTablet600 mg/1OralClinical Solutions Wholsesale2009-11-232017-06-24Us
IbuprofenTablet400 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-11-23Not applicableUs
IbuprofenTablet, film coated400 mg/1OralAmneal Pharmaceuticals of New York Llc2014-04-01Not applicableUs
IbuprofenTablet600 mg/1OralCardinal Health2009-11-232015-12-29Us
IbuprofenTablet, film coated800 mg/1OralMajor2009-06-10Not applicableUs
IbuprofenTablet800 mg/1OralRemedy Repack2013-07-162017-12-16Us
IbuprofenSuspension100 mg/5mLOralPreferreed Pharmaceuticals Inc.2011-07-05Not applicableUs
IbuprofenTablet400 mg/1OralMesource Pharmaceuticals2009-11-23Not applicableUs
IbuprofenTablet800 mg/1OralNucare Pharmaceuticals, Inc.2009-11-23Not applicableUs
IbuprofenTablet, film coated800 mg/1OralTime Cap Laboratories2015-12-30Not applicableUs
IbuprofenTablet, film coated800 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2015-12-21Not applicableUs
IbuprofenTablet400 mg/1OralIngenus Pharmaceuticals Llc2015-10-02Not applicableUs
IbuprofenTablet, film coated400 mg/1OralAi Ping Pharmaceutical, Inc.2016-11-23Not applicableUs
IbuprofenTablet400 mg/1OralRemedy Repack2014-06-052017-02-16Us
IbuprofenTablet400 mg/1OralPreferreed Pharmaceuticals Inc.2009-11-23Not applicableUs
IbuprofenTablet400 mg/1OralA S Medication Solutions2009-11-232017-06-20Us
IbuprofenTablet, film coated600 mg/1OralA S Medication Solutions2015-12-212017-06-20Us
IbuprofenTablet400 mg/1OralCardinal Health2012-02-222017-04-27Us
IbuprofenTablet600 mg/1OralRemedy Repack2017-04-05Not applicableUs
IbuprofenTablet400 mg/1OralBlenheim Pharmacal, Inc.2014-02-04Not applicableUs
IbuprofenTablet400 mg/1OralStat Rx USA2008-11-20Not applicableUs
IbuprofenTablet600 mg/1OralGolden State Medical Supply2009-11-23Not applicableUs
IbuprofenTablet600 mg/1OralRed Pharm Drug, Inc.2016-04-14Not applicableUs
IbuprofenTablet600 mg/1OralAidarex Pharmaceuticals LLC2009-11-23Not applicableUs
IbuprofenTablet, film coated200 mg/1Oralbryant ranch prepack2004-01-01Not applicableUs
IbuprofenTablet800 mg/1OralAv Kare, Inc.2013-01-10Not applicableUs
IbuprofenTablet800 mg/1OralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
IbuprofenTablet400 mg/1OralContract Pharmacy Services Pa2009-09-22Not applicableUs
IbuprofenTablet800 mg/1OralAscend Laboratories, LLC2012-02-22Not applicableUs
Ibuprofen Immediate ReleaseTablet400 mg/1OralShasun Pharmaceuticals Limited2009-02-05Not applicableUs
Ibuprofen Immediate ReleaseTablet800 mg/1OralShasun Pharmaceuticals Limited2009-02-05Not applicableUs
Ibuprofen Immediate ReleaseTablet600 mg/1OralShasun Pharmaceuticals Limited2009-02-05Not applicableUs
Ibuprofen LysineSolution10 mg/mLIntravenousX Gen Pharmaceuticals, Inc.2016-04-08Not applicableUs
Perrigo IbuprofenTablet600 mg/1OralPerrigo International2006-03-16Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7 Select Childrens IbuprofenSuspension100 mg/5mLOral7 Eleven2014-08-05Not applicableUs
7 Select IbuprofenTablet, film coated200 mg/1Oral7 Eleven2014-08-07Not applicableUs
7 Select IbuprofenTablet, coated200 mg/1Oral7 Eleven2014-05-13Not applicableUs
Actiprofen - Caplet 200mgTablet200 mgOralBayer Inc Consumer Care1996-12-311999-11-03Canada
AdvilTablet, coated256 mg/1OralPfizer2013-07-08Not applicableUs
AdvilTablet, coated200 mg/1OralPfizer1984-05-18Not applicableUs
AdvilTablet200 mg/1OralNavajo Manuracturing Company2016-09-20Not applicableUs
AdvilTablet, coated200 mg/1OralPfizer1984-05-18Not applicableUs
AdvilCapsule, liquid filled200 mg/1OralPfizer1995-04-10Not applicableUs
AdvilTablet, coated200 mg/1OralPfizer1984-05-18Not applicableUs
AdvilTablet, coated200 mg/1OralPfizer1984-05-18Not applicableUs
AdvilTablet, coated200 mg/1OralPfizer1984-05-18Not applicableUs
AdvilTablet, coated200 mg/1OralPfizer1984-05-18Not applicableUs
AdvilTablet, coated256 mg/1OralPfizer2013-07-08Not applicableUs
AdvilTablet, coated200 mg/1OralPfizer1984-05-18Not applicableUs
AdvilTablet, coated200 mg/1OralLil' Drug Store Products, Inc.2010-02-22Not applicableUs
AdvilCapsule, liquid filled200 mg/1OralPfizer1995-04-10Not applicableUs
AdvilTablet, coated200 mg/1OralPfizer1984-05-18Not applicableUs
Advil 12 HourTablet, extended release600 mgOralPfizer Laboratories Div Pfizer Inc.2016-08-22Not applicableCanada
Advil Arthritis PainCapsule400 mgOralPfizer Laboratories Div Pfizer Inc.2014-07-07Not applicableCanada
Advil CapletsTablet200 mgOralPfizer Laboratories Div Pfizer Inc.1992-12-31Not applicableCanada
Advil Extra Strength CapletsTablet400 mgOralPfizer Laboratories Div Pfizer Inc.2002-05-14Not applicableCanada
Advil Extra Strength Liqui-gelsCapsule400 mgOralPfizer Laboratories Div Pfizer Inc.2004-06-21Not applicableCanada
Advil Gel CapletsTablet200 mgOralPfizer Laboratories Div Pfizer Inc.1997-05-05Not applicableCanada
Advil Headache & Migraine Pain CapletsTablet200 mgOralPfizer Laboratories Div Pfizer Inc.Not applicableNot applicableCanada
Advil Headache & Migraine Pain Extra Strength CapletsTablet400 mgOralPfizer Laboratories Div Pfizer Inc.Not applicableNot applicableCanada
Advil Headache & Migraine Pain TabletsTablet200 mgOralPfizer Laboratories Div Pfizer Inc.Not applicableNot applicableCanada
Advil Liqui-gelsCapsule200 mgOralPfizer Laboratories Div Pfizer Inc.2000-10-02Not applicableCanada
Advil LiquigelsCapsule200 mg/1OralNavajo Manuracturing Company2016-09-20Not applicableUs
Advil LiquigelsCapsule, liquid filled200 mg/1OralLil' Drug Store Products, Inc.2012-05-01Not applicableUs
Advil Menstrual PainTablet, coated256 mg/1OralPfizer2016-06-30Not applicableUs
Advil MigraineCapsule, liquid filled200 mg/1OralPfizer2000-03-16Not applicableUs
Advil Muscle and JointTablet400 mgOralPfizer Laboratories Div Pfizer Inc.2011-11-07Not applicableCanada
Advil Pediatric DropsSuspension40 mgOralPfizer Laboratories Div Pfizer Inc.2000-10-23Not applicableCanada
Advil Pediatric Drops Fever From Colds Or FluSuspension40 mgOralPfizer Laboratories Div Pfizer Inc.2010-08-06Not applicableCanada
Advil TabletsTablet200 mgOralPfizer Laboratories Div Pfizer Inc.1993-12-31Not applicableCanada
Alti-ibuprofen Tab 300mgTablet300 mgOralAltimed Pharma Inc.1983-12-311999-09-17Canada
Alti-ibuprofen Tab 400mgTablet400 mgOralAltimed Pharma Inc.1983-12-311999-09-17Canada
Apo Ibuprofen Tab 300mgTablet300 mgOralApotex Corporation1983-12-31Not applicableCanada
Apo Ibuprofen Tab 400mgTablet400 mgOralApotex Corporation1983-12-31Not applicableCanada
Apo-ibuprofen Tab 200mgTablet200 mgOralApotex Corporation1984-12-31Not applicableCanada
Aprofen Regular StrengthTablet200 mg/1OralA P J Laboratories Limited2013-02-21Not applicableUs
Assured IbuprofenTablet, film coated200 mg/1OralSpirit Pharmaceuticals, Llc2016-01-06Not applicableUs
Babies R Us IbuprofenSuspension100 mg/5mLOralToys R Us2010-12-01Not applicableUs
Babies R Us Infants IbuprofenSuspension / drops50 mg/1.25mLOralToys R Us2010-12-01Not applicableUs
Being Well IbuprofenSuspension100 mg/5mLOralSave A Lot Food Stores, Ltd.2006-02-25Not applicableUs
Berkley and Jensen Childrens IbuprofenSuspension100 mg/5mLOralBJWC2016-08-25Not applicableUs
Berkley and Jensen IbuprofenTablet200 mg/1OralBJWC2007-06-20Not applicableUs
Berkley and Jensen IbuprofenCapsule, liquid filled200 mg/1OralBJWC2017-03-03Not applicableUs
Berkley and Jensen IbuprofenTablet, film coated200 mg/1OralBJWC2009-01-15Not applicableUs
Berkley and Jensen Ibuprofen Childrens Dye FreeSuspension100 mg/5mLOralBJWC2010-01-07Not applicableUs
Care One IbuprofenSuspension / drops50 mg/1.25mLOralAmerican Sales Company2006-05-16Not applicableUs
Care One IbuprofenTablet200 mg/1OralAmerican Sales Company2004-04-13Not applicableUs
Care One IbuprofenTablet, chewable100 mg/1OralAmerican Sales Company2004-09-13Not applicableUs
Care One IbuprofenTablet, coated200 mg/1OralAmerican Sales Company2004-04-13Not applicableUs
Care One IbuprofenSuspension100 mg/5mLOralAmerican Sales Company2004-04-28Not applicableUs
Care One Ibuprofen ChildrensSuspension100 mg/5mLOralAmerican Sales Company2004-05-04Not applicableUs
Care One Ibuprofen ChildrensSuspension100 mg/5mLOralAmerican Sales Company2004-04-28Not applicableUs
Care One Ibuprofen ChildrensSuspension100 mg/5mLOralAmerican Sales Company2008-08-01Not applicableUs
Care One Ibuprofen IbTablet, coated200 mg/1OralAmerican Sales Company2006-05-09Not applicableUs
Care One Ibuprofen IbTablet, film coated200 mg/1OralAmerican Sales Company2006-05-24Not applicableUs
Care One Ibuprofen InfantsSuspension50 mg/1.25mLOralAmerican Sales Company2004-05-11Not applicableUs
Care One Ibuprofen Junior StrengthTablet, chewable100 mg/1OralAmerican Sales Company2010-05-21Not applicableUs
Careall IbuprofenTablet200 mg/1OralNew World Imports2016-03-15Not applicableUs
Careone IbuprofenTablet, film coated200 mg/1OralAmerican Sales Company2016-07-20Not applicableUs
Careone IbuprofenTablet, coated200 mg/1OralAmerican Sales Company2016-07-20Not applicableUs
Careone Ibuprofen Junior StrengthTablet, chewable100 mg/1OralAmerican Sales Company2010-05-21Not applicableUs
CedaprinTablet200 mg/1OralNorth Safety Products2012-03-07Not applicableUs
Children's AdvilSuspension100 mgOralPfizer Laboratories Div Pfizer Inc.1997-11-03Not applicableCanada
Children's Advil Chewable TabletsTablet, chewable50 mgOralPfizer Laboratories Div Pfizer Inc.Not applicableNot applicableCanada
Children's Advil Fever From Colds Or FluSuspension100 mgOralPfizer Laboratories Div Pfizer Inc.2009-11-05Not applicableCanada
Children's EuroprofenSuspension100 mgOralPendopharm Division Of De Pharmascience Inc2011-02-14Not applicableCanada
Children's Ibuprofen SuspensionSuspension100 mgOralPerrigo International2007-08-30Not applicableCanada
Children's MotrinSuspension100 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1997-12-102002-07-19Canada
Children's Motrin Chewable Tablet 50mgTablet50 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2001-02-122005-07-22Canada
Children's Motrin Chewable TabletsTablet50 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2003-05-14Not applicableCanada
Children's Motrin SuspensionSuspension100 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2000-09-15Not applicableCanada
Childrens AdvilSuspension100 mg/5mLOralPfizer2010-06-28Not applicableUs
Childrens AdvilSuspension100 mg/5mLOralPfizer1996-06-27Not applicableUs
Childrens AdvilSuspension100 mg/5mLOralPfizer1996-06-27Not applicableUs
Childrens AdvilSuspension100 mg/5mLOralPfizer2012-09-04Not applicableUs
Childrens AdvilSuspension100 mg/5mLOralPfizer2013-12-20Not applicableUs
Childrens AdvilSuspension100 mg/5mLOralPfizer1996-06-27Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralFred's2006-06-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralChain Drug Marketing Association2006-10-09Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralFamily Dollar Services2006-08-04Not applicableUs
Childrens IbuprofenSolution100 mg/5mLOralNash Finch Company (Our Family)2006-07-18Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralActavis Mid Atlantic LLC,2006-06-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralH.E.B.2002-06-19Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralMeijer Distribution1994-11-21Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralRugby2006-06-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralStephen L. La France Pharmacy, Inc.2006-05-25Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralActavis Pharma Company2016-08-04Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralKinray2006-06-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralWalgreen2010-05-24Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralChain Drug Consortium2006-06-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralChain Drug Marketing Association2014-10-10Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralValue Merchandisers2008-01-16Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralActavis Mid Atlantic LLC,2006-06-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralFred's2008-03-24Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralChain Drug Consortium2006-06-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralPerrigo New York Inc.2014-04-09Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralWalmart Stores2012-05-17Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralShopko Stores Operating2016-08-10Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralKinray2006-06-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralShopko Stores Operating2016-08-03Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralWalgreen2010-05-24Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralPharmaceutical Associates, Inc.2014-12-01Not applicableUs
Childrens IbuprofenSuspension200 mg/10mLOralCardinal Health2006-09-14Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralRugby2015-09-15Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralSafeway2002-05-02Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralChain Drug Marketing Association2008-01-10Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralValue Merchandisers2006-10-09Not applicableUs
Childrens IbuprofenSolution100 mg/5mLOralNash Finch Company (Our Family)2006-07-18Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralActavis Mid Atlantic LLC,2006-06-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralPrecision Dose, Inc.2004-04-13Not applicableUs
Childrens IbuprofenSolution100 mg/5mLOralPreferred Plus (Kinray)2014-06-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralCvs Health2014-02-09Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralRite Aid2008-03-20Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralKinray2006-06-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralWalgreen2010-05-24Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralChain Drug Consortium2006-06-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralFamily Dollar Services2012-02-23Not applicableUs
Childrens IbuprofenLiquid100 mg/5mLOralWestern Family Foods2008-08-18Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralShopko Stores Operating2013-07-30Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralCardinal Health2004-04-13Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralMeijer Distribution2016-09-07Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralStephen L. La France Pharmacy, Inc.2008-02-13Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralProficient Rx LP2006-06-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralCvs Health2016-04-13Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralChain Drug Marketing Association2010-03-04Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralRite Aid2002-05-10Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralPerrigo New York Inc.2014-04-09Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralChain Drug Consortium2012-12-06Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralValue Merchandisers2012-05-23Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralA S Medication Solutions2006-06-012017-06-20Us
Childrens IbuprofenSuspension100 mg/5mLOralActavis Mid Atlantic LLC,2006-06-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralMeijer Distribution2014-04-23Not applicableUs
Childrens IbuprofenSuspension200 mg/10mLOralPrecision Dose, Inc.2006-09-14Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralPreferreed Pharmaceuticals Inc.2011-08-24Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralWalgreen2016-08-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralWalmart Stores2012-05-17Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralCvs Health2014-01-29Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralKinray2006-06-01Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralWalgreen2010-05-24Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralWestern Family Foods2002-10-07Not applicableUs
Childrens IbuprofenSuspension100 mg/5mLOralChain Drug Consortium2006-06-01Not applicableUs
Childrens Ibuprofen 100Suspension100 mg/5mLOralWalgreen2016-09-08Not applicableUs
Childrens Ibuprofen 100 Dye FreeSuspension100 mg/5mLOralWalgreen2014-02-24Not applicableUs
Childrens Ibuprofen Oral SuspensionSuspension100 mg/5mLOralMeijer Distribution2002-03-19Not applicableUs
Childrens MotrinSuspension100 mg/5mLOralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2016-01-25Not applicableUs
Childrens MotrinSuspension100 mg/5mLOralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division1995-09-01Not applicableUs
Childrens MotrinSuspension100 mg/5mLOralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2016-01-25Not applicableUs
Childrens MotrinSuspension100 mg/5mLOralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2001-09-01Not applicableUs
Circle K IbuprofenTablet, film coated200 mg/1OralLil' Drug Store Products, Inc.2016-06-21Not applicableUs
Circle K IbuprofenTablet, coated200 mg/1OralLil' Drug Store Products, Inc.2014-11-01Not applicableUs
Clear Choice IbuprofenTablet200 mg/1OralAthlete's Needs2012-10-09Not applicableUs
Concentrated IbuprofenSuspension50 mg/1.25mLOralTris Pharma, Inc.2012-11-062016-12-08Us
Counteract IbTablet, coated200 mg/1OralMelaleuca, Inc.2011-04-30Not applicableUs
Counteract IbTablet, film coated200 mg/1OralMelaleuca, Inc.2010-03-18Not applicableUs
Cvs Ibuprofen SodiumTablet, film coated256 mg/1OralCvs Health2017-01-10Not applicableUs
Cvs Pharmacy IbuprofenCapsule, liquid filled200 mg/1OralCvs Health2009-12-04Not applicableUs
Dg Health Childrens IbuprofenSuspension100 mg/5mLOralDolgencorp2016-04-20Not applicableUs
Dg Health Childrens IbuprofenSuspension100 mg/5mLOralDolgencorp2016-05-02Not applicableUs
Dg Health IbuprofenTablet, coated200 mg/1OralDolgencorp2010-02-01Not applicableUs
Dg Health IbuprofenSuspension / drops50 mg/1.25mLOralDolgencorp2010-04-27Not applicableUs
Dg Health IbuprofenTablet, film coated200 mg/1OralDolgencorp2009-10-03Not applicableUs
Dg Health IbuprofenSuspension50 mg/1.25mLOralDolgencorp2010-02-22Not applicableUs
Dg Health IbuprofenSuspension100 mg/5mLOralDolgencorp2010-02-06Not applicableUs
Direct Safety IbuprofenTablet, coated200 mg/1OralConney Safety Products, LLC2016-02-01Not applicableUs
Direct Safety IbuprofenTablet, coated200 mg/1OralConney Safety Products, LLC2014-11-17Not applicableUs
Direct Safety IbuprofenTablet, film coated200 mg/1OralConney Safety Products, LLC2013-05-032018-02-01Us
DolexTablet200 mg/1OralPharmadel LLC2013-03-25Not applicableUs
Dover AddaprinTablet, film coated200 mg/1OralUnifirst First Aid2008-12-30Not applicableUs
Dover AddaprinTablet, coated200 mg/1OralUnifirst First Aid2016-02-01Not applicableUs
Dover AddaprinTablet, coated200 mg/1OralUnifirst First Aid2014-11-17Not applicableUs
Dragon TabsTablet200 mg/1OralGenomma Lab2015-04-17Not applicableUs
Dye Free Childrens IbuprofenSuspension100 mg/5mLOralPrecision Dose, Inc.2015-08-26Not applicableUs
Dye Free IbuprofenTablet200 mg/1OralWalgreen2004-03-11Not applicableUs
Equaline Childrens IbuprofenSuspension100 mg/5mLOralSupervalu2004-09-24Not applicableUs
Equaline IbuprofenSuspension50 mg/1.25mLOralSupervalu2004-09-07Not applicableUs
Equaline IbuprofenSuspension100 mg/5mLOralSupervalu2010-09-27Not applicableUs
Equaline IbuprofenTablet, chewable100 mg/1OralSupervalu2011-05-04Not applicableUs
Equaline IbuprofenSuspension / drops50 mg/1.25mLOralSupervalu2004-12-22Not applicableUs
Equaline IbuprofenTablet, coated200 mg/1OralSupervalu2006-03-07Not applicableUs
Equaline IbuprofenTablet200 mg/1OralSupervalu2004-08-05Not applicableUs
Equaline IbuprofenTablet, film coated200 mg/1OralSupervalu2006-04-28Not applicableUs
Equaline IbuprofenTablet, coated200 mg/1OralSupervalu2004-08-17Not applicableUs
Equaline Ibuprofen ChildrensSuspension100 mg/5mLOralSupervalu2004-09-24Not applicableUs
Equaline Ibuprofen ChildrensSuspension100 mg/5mLOralSupervalu2004-08-30Not applicableUs
Equaline Ibuprofen ChildrensSuspension100 mg/5mLOralSupervalu2004-10-07Not applicableUs
Equate IbuprofenTablet200 mg/1OralWalmart Stores1989-10-15Not applicableUs
Equate IbuprofenSuspension100 mg/5mLOralWalmart Stores1999-02-02Not applicableUs
Equate IbuprofenTablet, chewable100 mg/1OralWalmart Stores2011-10-25Not applicableUs
Equate IbuprofenTablet, coated200 mg/1OralWalmart Stores1989-09-15Not applicableUs
Equate IbuprofenCapsule, liquid filled200 mg/1OralWalmart Stores2014-07-02Not applicableUs
Equate IbuprofenTablet, film coated200 mg/1OralWalmart Stores2016-03-02Not applicableUs
Equate IbuprofenTablet, film coated200 mg/1OralWalmart Stores2013-08-13Not applicableUs
Equate Ibuprofen ChildrensSuspension100 mg/5mLOralWalmart Stores2002-04-16Not applicableUs
Equate Ibuprofen ChildrensSuspension100 mg/5mLOralWalmart Stores2010-08-19Not applicableUs
Extra Strength IbuprofenTablet400 mgOralVita Health Products Inc2002-11-222008-08-05Canada
Extra Strength IbuprofenTablet400 mgOralPharmascience Inc2010-02-01Not applicableCanada
Extra Strength IbuprofenTablet400 mgOralVita Health Products IncNot applicableNot applicableCanada
Extra Strength IbuprofenTablet400 mgOralTevaNot applicableNot applicableCanada
Extra Strength Ibuprofen Liquid CapsulesCapsule400 mgOralVita Health Products Inc2011-06-10Not applicableCanada
Extra Strength Ibuprofen Liquid Filled CapsulesCapsule400 mgOralApotex Corporation2009-03-16Not applicableCanada
Extra Strength Ibuprofen Liquid Gel CapsulesCapsule400 mgOralApotex Corporation2012-07-15Not applicableCanada
Family Wellness Childrens IbuprofenSuspension100 mg/5mLOralFamily Dollar Services2002-08-22Not applicableUs
Fast Pain ReliefTablet, coated200 mg/1OralHealth Life Of Usa2011-01-01Not applicableUs
Fast Pain ReliefTablet, coated200 mg/1OralWe Care Distributor Inc.2015-12-02Not applicableUs
Flex-prinTablet200 mg/1OralProvision Medical2015-03-31Not applicableUs
Formu Care IbuprofenTablet200 mg/1OralAccess Business Group1991-01-15Not applicableUs
Formu Care Ibuprofen ChildrensSuspension100 mg/5mLOralAccess Business Group1999-01-19Not applicableUs
Fulton Street Market IbuprofenTablet, film coated200 mg/1OralAccess Business Group1991-01-15Not applicableUs
Good Neighbor Pharmacy Childrens IbuprofenSuspension100 mg/5mLOralAmerisource Bergen2002-04-02Not applicableUs
Good Neighbor Pharmacy Childrens IbuprofenSuspension100 mg/5mLOralAmerisource Bergen2002-04-02Not applicableUs
Good Neighbor Pharmacy Childrens IbuprofenSuspension100 mg/5mLOralAmerisource Bergen2002-05-13Not applicableUs
Good Neighbor Pharmacy IbuprofenSuspension100 mg/5mLOralAmerisource Bergen1999-11-22Not applicableUs
Good Neighbor Pharmacy IbuprofenTablet, film coated200 mg/1OralAmerisource Bergen2006-06-14Not applicableUs
Good Neighbor Pharmacy IbuprofenTablet, chewable100 mg/1OralAmerisource Bergen2004-10-12Not applicableUs
Good Neighbor Pharmacy IbuprofenTablet, coated200 mg/1OralAmerisource Bergen1989-09-15Not applicableUs
Good Neighbor Pharmacy IbuprofenTablet100 mg/1OralAmerisource Bergen2009-10-19Not applicableUs
Good Neighbor Pharmacy IbuprofenTablet, coated200 mg/1OralAmerisource Bergen2006-03-28Not applicableUs
Good Neighbor Pharmacy IbuprofenSuspension / drops50 mg/1.25mLOralAmerisource Bergen2004-10-12Not applicableUs
Good Neighbor Pharmacy IbuprofenSuspension100 mg/5mLOralAmerisource Bergen1999-01-28Not applicableUs
Good Neighbor Pharmacy IbuprofenTablet200 mg/1OralAmerisource Bergen1990-01-15Not applicableUs
Good Neighbor Pharmacy IbuprofenTablet, film coated256 mg/1OralAmerisource Bergen2016-03-21Not applicableUs
Good Neighbor Pharmacy Ibuprofen ChildrensSuspension100 mg/5mLOralAmerisource Bergen1994-08-09Not applicableUs
Good Sense Childrens Ibuprofen Oral SuspensionSuspension100 mg/5mLOralL. Perrigo Company2002-04-09Not applicableUs
Good Sense IbuprofenTablet, coated200 mg/1OralL. Perrigo Company1991-02-15Not applicableUs
Good Sense IbuprofenSuspension100 mg/5mLOralL. Perrigo Company1994-05-09Not applicableUs
Good Sense IbuprofenTablet, coated200 mg/1OralL. Perrigo Company2006-03-10Not applicableUs
Good Sense IbuprofenTablet, chewable100 mg/1OralL. Perrigo Company2004-11-09Not applicableUs
Good Sense IbuprofenTablet, chewable100 mg/1OralDispensing Solutions, Inc.2004-11-09Not applicableUs
Good Sense IbuprofenCapsule, liquid filled200 mg/1OralL. Perrigo Company2010-01-28Not applicableUs
Good Sense IbuprofenTablet, film coated200 mg/1OralL. Perrigo Company2006-04-27Not applicableUs
Good Sense IbuprofenTablet, film coated200 mg/1OralL. Perrigo Company1989-09-15Not applicableUs
Good Sense Ibuprofen ChildrensSuspension100 mg/5mLOralL. Perrigo Company1999-01-07Not applicableUs
Good Sense Ibuprofen ChildrensSuspension100 mg/5mLOralL. Perrigo Company2002-05-04Not applicableUs
Good Sense Ibuprofen ChildrensSuspension100 mg/5mLOralL. Perrigo Company2002-04-09Not applicableUs
Good Sense Ibuprofen ChildrensSuspension100 mg/5mLOralRebel Distributors1999-01-07Not applicableUs
Good Sense Ibuprofen InfantsSuspension50 mg/1.25mLOralL. Perrigo Company2000-02-08Not applicableUs
Good Sense Infants IbuprofenSuspension / drops50 mg/1.25mLOralL. Perrigo Company2016-02-05Not applicableUs
Green Guard Ibupro ReliefTablet, coated200 mg/1OralUnifirst First Aid2016-02-01Not applicableUs
Green Guard Ibupro ReliefTablet, film coated200 mg/1OralUnifirst First Aid2008-12-30Not applicableUs
Green Guard Ibuprofen ReliefTablet, coated200 mg/1OralUnifirst First Aid2014-11-17Not applicableUs
Handy Solutions IbuprofenTablet200 mg/1OralNavajo Manuracturing Company2016-09-22Not applicableUs
Harmon Face Values IbuprofenSuspension100 mg/5mLOralHarmon Stores2011-12-18Not applicableUs
Harris Teeter Childrens IbuprofenSuspension100 mg/5mLOralHarris Teeter2015-11-21Not applicableUs
Harris Teeter Childrens IbuprofenSuspension100 mg/5mLOralHarris Teeter2015-11-21Not applicableUs
Harris Teeter Childrens IbuprofenSuspension100 mg/5mLOralHarris Teeter2016-06-14Not applicableUs
Harris Teeter IbuprofenSuspension / drops50 mg/1.25mLOralHarris Teeter2015-11-05Not applicableUs
Harris Teeter Ibuprofen InfantsSuspension50 mg/1.25mLOralHarris Teeter2015-11-21Not applicableUs
Health Mart Childrens IbuprofenSuspension100 mg/5mLOralMc Kesson2013-08-13Not applicableUs
Health Mart Childrens IbuprofenSuspension100 mg/5mLOralMc Kesson2011-11-29Not applicableUs
Health Mart IbuprofenSuspension50 mg/1.25mLOralMc Kesson2011-11-21Not applicableUs
Health Mart IbuprofenSuspension100 mg/5mLOralMc Kesson2011-11-21Not applicableUs
Health Mart IbuprofenSuspension / drops50 mg/1.25mLOralMc Kesson2011-11-21Not applicableUs
Health Mart IbuprofenTablet, coated200 mg/1OralMc Kesson2011-11-21Not applicableUs
Health Mart IbuprofenTablet, film coated200 mg/1OralMc Kesson2011-11-21Not applicableUs
Health Mart IbuprofenTablet, coated200 mg/1OralMc Kesson2011-11-21Not applicableUs
Health Mart IbuprofenSuspension100 mg/5mLOralMc Kesson2011-11-21Not applicableUs
Health Mart Ibuprofen IbTablet, coated200 mg/1OralMc Kesson2011-11-21Not applicableUs
Health Mart Ibuprofen IbTablet, film coated200 mg/1OralMc Kesson2013-10-26Not applicableUs
Health Sense Infants Ibuprofen Oral SuspensionSuspension50 mg/1.25mLOralDolgencorp2009-06-08Not applicableUs
Health Sense ProvilTablet, film coated200 mg/1OralPrime Marketing, LLC2006-01-01Not applicableUs
Healthy Accents IbuprofenTablet, film coated200 mg/1OralDza Brands,2009-03-20Not applicableUs
Healthy Accents IbuprofenSuspension / drops50 mg/1.25mLOralDza Brands,2011-06-06Not applicableUs
Healthy Accents IbuprofenTablet, film coated200 mg/1OralDza Brands,2008-01-22Not applicableUs
Healthy Accents IbuprofenTablet, chewable100 mg/1OralDza Brands,2011-06-30Not applicableUs
Healthy Accents IbuprofenTablet, film coated200 mg/1OralDza Brands,2013-05-22Not applicableUs
Healthy Accents IbuprofenTablet, coated200 mg/1OralDza Brands,2008-05-17Not applicableUs
Healthy Accents IbuprofenSuspension100 mg/5mLOralDza Brands,2008-03-03Not applicableUs
Healthy Accents IbuprofenTablet, chewable100 mg/1OralDza Brands,2016-05-24Not applicableUs
Healthy Accents Ibuprofen ChildrensSuspension100 mg/5mLOralDza Brands,2008-03-03Not applicableUs
Healthy Accents Ibuprofen InfantsSuspension50 mg/1.25mLOralDza Brands,2008-02-18Not applicableUs
Help I Have An Aching BodyTablet200 mg/1OralHelp Remedies, Inc.2009-07-01Not applicableUs
Henry Schein IbuprofenTablet, film coated200 mg/1OralHenry Schein2015-12-15Not applicableUs
Henry Schein IbuprofenTablet, film coated200 mg/1OralHenry Schein2008-12-30Not applicableUs
Humana Pharmacy Childrens IbuprofenSuspension100 mg/5mLOralHumana, Inc2016-12-21Not applicableUs
Humana Pharmacy IbuprofenTablet, film coated200 mg/1OralHumana, Inc2016-12-21Not applicableUs
IbuprofenTablet200 mg/1OralChain Drug Consortium2014-11-04Not applicableUs
IbuprofenTablet, film coated200 mg/1OralLnk International, Inc.1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralRugby1988-05-24Not applicableUs
IbuprofenTablet, coated200 mg/1OralWestern Family Foods2013-11-30Not applicableUs
IbuprofenTablet, film coated200 mg/1OralProficient Rx LP1988-05-24Not applicableUs
IbuprofenSuspension50 mg/1.25mLOralCentral Texas Community Health Centers2003-08-28Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralSam's West, Inc2015-05-31Not applicableUs
IbuprofenTablet200 mg/1OralKroger2011-02-02Not applicableUs
IbuprofenTablet200 mg/1OralGeiss, Destin & Dunn, Inc (Goodsense)2011-12-22Not applicableUs
IbuprofenTablet200 mg/1OralMARKSANS PHARMA LIMITED2011-07-25Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralValu Merchandisers Company (Best Choice)2010-08-21Not applicableUs
IbuprofenSuspension100 mg/5mLOralKroger2011-04-25Not applicableUs
IbuprofenTablet, coated200 mg/1OralMeijer Distribution1988-11-15Not applicableUs
IbuprofenTablet, film coated200 mg/1OralRaining Rose2015-08-01Not applicableUs
IbuprofenTablet200 mg/1OralTopcare (Topco Associates Llc)2014-02-28Not applicableUs
IbuprofenTablet, film coated200 mg/1OralL&R Distributors, Inc.1988-05-24Not applicableUs
IbuprofenTablet, coated200 mg/1OralMeijer Distribution2006-06-21Not applicableUs
IbuprofenTablet, film coated200 mg/1OralWalgreen1988-05-24Not applicableUs
IbuprofenTablet, chewable100 mg/1OralShopko Stores Operating2013-08-06Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralWestern Family Foods2014-09-30Not applicableUs
IbuprofenTablet, coated200 mg/1OralHannaford Brothers Company2006-05-31Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralChain Drug Consortium2014-12-31Not applicableUs
IbuprofenSuspension100 mg/5mLOralWestern Family Foods1999-01-28Not applicableUs
IbuprofenTablet, coated200 mg/1OralPublix Supermarkets, Inc.2006-03-22Not applicableUs
IbuprofenTablet, film coated200 mg/1OralWalmart Stores1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralA S Medication Solutions1999-03-012017-06-20Us
IbuprofenTablet, film coated200 mg/1OralPreferreed Pharmaceuticals Inc.2014-01-02Not applicableUs
IbuprofenTablet, film coated200 mg/1OralL&R Distributors, Inc.2002-04-08Not applicableUs
IbuprofenTablet, coated200 mg/1OralH.E.B.1991-08-09Not applicableUs
IbuprofenTablet, coated200 mg/1OralAAA Pharmaceutical, Inc.2012-12-04Not applicableUs
IbuprofenTablet, film coated200 mg/1OralChain Drug Marketing Association1988-05-24Not applicableUs
IbuprofenTablet, coated200 mg/1OralDolgencorp, Inc. (Dollar General & Rexall)2017-04-30Not applicableUs
IbuprofenTablet, coated200 mg/1OralTarget Corporation.2014-03-28Not applicableUs
IbuprofenTablet, film coated200 mg/1OralSupervalu1988-05-24Not applicableUs
IbuprofenTablet, coated200 mg/1OralCvs Health2001-07-31Not applicableUs
IbuprofenTablet400 mgOralD.C. Labs Limited2003-09-222005-07-19Canada
IbuprofenTablet, film coated200 mg/1OralRite Aid2002-04-08Not applicableUs
IbuprofenTablet200 mg/1OralKinray2011-07-25Not applicableUs
IbuprofenTablet, film coated200 mg/1OralCardinal Health2011-06-03Not applicableUs
IbuprofenTablet, coated200 mg/1OralPublix Supermarkets, Inc.1988-09-15Not applicableUs
IbuprofenTablet, film coated200 mg/1OralArmy + Air Force Exchange Service1988-05-24Not applicableUs
IbuprofenTablet, coated200 mg/1OralAvema Pharma Solutions2013-08-01Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralJ.P. BUSINESS ENTERPRISE2013-08-20Not applicableUs
IbuprofenTablet, film coated200 mg/1OralAi Ping Pharmaceutical, Inc.2017-05-08Not applicableUs
IbuprofenTablet200 mg/1OralKroger2014-02-28Not applicableUs
IbuprofenSuspension100 mg/5mLOralCvs Health2002-08-27Not applicableUs
IbuprofenTablet, film coated200 mg/1OralChain Drug Consortium1988-05-24Not applicableUs
IbuprofenTablet200 mgOralD.C. Labs Limited2000-10-112005-07-19Canada
IbuprofenTablet, chewable100 mg/1OralRite Aid2004-05-06Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralCostco Wholesale2010-07-08Not applicableUs
IbuprofenTablet200 mg/1OralSupervalu2002-04-08Not applicableUs
IbuprofenTablet200 mg/1OralMedline Industries2013-01-15Not applicableUs
IbuprofenTablet, film coated200 mg/1OralCentral Texas Community Health Centers2003-06-24Not applicableUs
IbuprofenTablet200 mg/1OralPhysicians Total Care, Inc.2007-10-16Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralMc Kesson (Health Mart)2012-04-09Not applicableUs
IbuprofenTablet400 mgOralApotex CorporationNot applicableNot applicableCanada
IbuprofenTablet, coated200 mg/1OralSafeway1997-07-30Not applicableUs
IbuprofenTablet, film coated200 mg/1OralTime Cap Laboratories2012-04-16Not applicableUs
IbuprofenCapsule, coated200 mg/1OralGreat Lakes Wholesale, Marketing, and Sales, Inc.1988-05-24Not applicableUs
IbuprofenTablet200 mg/1OralArmy + Air Force Exchange Service1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralWalmart Stores2002-04-082019-07-08Us
IbuprofenLiquid100 mg/5mLOralWalgreen2008-07-24Not applicableUs
IbuprofenTablet, coated200 mg/1OralCvs Health2015-10-07Not applicableUs
IbuprofenTablet, film coated200 mg/1OralMeijer Distribution1993-04-01Not applicableUs
IbuprofenTablet, film coated200 mg/1OralDirectrx2014-01-01Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralPura Cap Pharmaceutical Llc.2016-10-12Not applicableUs
IbuprofenTablet200 mg/1OralInternational Laboratories, Llc2016-06-01Not applicableUs
IbuprofenTablet200 mg/1OralGranules India Limited2011-01-01Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralSMART SENSE (Kmart)2012-09-30Not applicableUs
IbuprofenTablet, coated200 mg/1OralAAA Pharmaceutical, Inc.2012-12-04Not applicableUs
IbuprofenTablet, film coated200 mg/1OralFred's1988-05-24Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralH.E.B.2013-01-08Not applicableUs
IbuprofenTablet, chewable100 mg/1OralHyvee2005-02-12Not applicableUs
IbuprofenTablet200 mg/1OralKinray2016-03-01Not applicableUs
IbuprofenTablet, coated200 mg/1OralKroger2006-03-11Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralPL Developments2012-05-17Not applicableUs
IbuprofenTablet, film coated200 mg/1OralChain Drug Marketing Association1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralKroger2015-08-28Not applicableUs
IbuprofenTablet200 mg/1OralGenuine First Aid2010-02-17Not applicableUs
IbuprofenTablet, chewable100 mg/1OralCvs Health1991-11-05Not applicableUs
IbuprofenTablet, film coated200 mg/1OralHarmon Store Inc.1988-05-24Not applicableUs
IbuprofenSuspension / drops50 mg/1.25mLOralRite Aid2005-06-03Not applicableUs
IbuprofenTablet, coated200 mg/1OralEQUATE (Walmart Stores, Inc.)2013-12-30Not applicableUs
IbuprofenTablet, film coated200 mg/1OralTime Cap Laboratories2016-11-16Not applicableUs
IbuprofenTablet200 mg/1OralLnk International, Inc.1988-05-24Not applicableUs
IbuprofenTablet200 mg/1OralKinray2011-07-25Not applicableUs
IbuprofenTablet, coated200 mg/1OralSMART SENSE (Kmart)2011-04-30Not applicableUs
IbuprofenSuspension / drops50 mg/1.25mLOralSafeway2005-07-11Not applicableUs
IbuprofenTablet200 mg/1OralContract Pharmacy Services Pa2010-08-16Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralRugby2012-03-26Not applicableUs
IbuprofenTablet, coated200 mg/1OralShopko Stores Operating2013-08-19Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralWalgreens2016-01-27Not applicableUs
IbuprofenTablet, film coated200 mg/1OralLnk International, Inc.1999-03-01Not applicableUs
IbuprofenTablet, chewable100 mg/1OralWestern Family Foods2009-04-07Not applicableUs
IbuprofenTablet, coated200 mg/1OralAvema Pharma Solutions2013-08-01Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralMARKSANS PHARMA LIMITED2011-05-09Not applicableUs
IbuprofenCapsule, liquid filled220 mg/1OralSpirit Pharmaceuticals, Llc2012-05-01Not applicableUs
IbuprofenTablet200 mg/1OralContract Pharmacal Corporation2014-01-15Not applicableUs
IbuprofenTablet, film coated200 mg/1OralA S Medication Solutions2011-01-182017-06-20Us
IbuprofenTablet, coated200 mg/1OralKroger2015-06-30Not applicableUs
IbuprofenTablet200 mg/1OralMARKSANS PHARMA LIMITED2015-11-06Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralSuper Valu (Equaline)2010-07-08Not applicableUs
IbuprofenTablet, coated200 mg/1OralFamily Dollar (FAMILY WELLNESS)2014-07-31Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralWalgreen2011-05-09Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralLIVE BETTER (The Great Atlantic & Pacific Tea Company)2013-03-25Not applicableUs
IbuprofenTablet, film coated200 mg/1OralNash Finch2002-03-30Not applicableUs
IbuprofenTablet, coated200 mg/1OralASSURED / DOLLAR TREE (Greenbrier International, Inc.)2016-12-31Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralWalgreens2013-09-30Not applicableUs
IbuprofenTablet, film coated200 mg/1OralBetter Living Brands1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralA S Medication Solutions2011-01-182017-06-20Us
IbuprofenTablet, film coated200 mg/1OralH.E.B.1988-05-24Not applicableUs
IbuprofenTablet, coated200 mg/1OralWestern Family Foods2011-09-01Not applicableUs
IbuprofenTablet, film coated200 mg/1OralHannaford Brothers Company1995-06-29Not applicableUs
IbuprofenTablet, coated200 mg/1OralTarget Corporation.2013-11-30Not applicableUs
IbuprofenSuspension / drops50 mg/1.25mLOralPublix Supermarkets, Inc.2011-09-09Not applicableUs
IbuprofenTablet, film coated200 mg/1OralAvera Mc Kennan Hospital2016-10-19Not applicableUs
IbuprofenTablet200 mg/1OralRebel Distributors2011-01-27Not applicableUs
IbuprofenTablet, coated200 mg/1OralFamily Dollar (FAMILY WELLNESS)2015-05-04Not applicableUs
IbuprofenTablet, coated200 mg/1OralShasun Pharmaceuticals Limited2011-04-04Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralMeijer2010-07-12Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralCardinal Health (Leader) 700002016-11-30Not applicableUs
IbuprofenTablet, coated200 mg/1OralWeeks & Leo Co., Inc.2013-05-17Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralBJWC (Berkley & Jensen / BJ's)2013-05-15Not applicableUs
IbuprofenTablet, film coated200 mg/1OralBetter Living Brands2002-03-30Not applicableUs
IbuprofenTablet, film coated200 mg/1OralRite Aid1988-05-24Not applicableUs
IbuprofenTablet, coated200 mg/1OralHealthy Accents (DZA Brands, LLC)2013-12-30Not applicableUs
IbuprofenTablet, film coated200 mg/1OralGreenbrier International, Inc.1999-03-01Not applicableUs
IbuprofenTablet200 mg/1OralMARKSANS PHARMA LIMITED2012-07-042015-12-29Us
IbuprofenCapsule, liquid filled200 mg/1OralHyvee2013-01-15Not applicableUs
IbuprofenTablet, chewable100 mg/1OralWalgreen2013-12-09Not applicableUs
IbuprofenTablet200 mg/1OralMeijer Distribution1988-02-15Not applicableUs
IbuprofenTablet, film coated200 mg/1OralGreenbrier International, Inc.1988-05-24Not applicableUs
IbuprofenSuspension100 mg/5mLOralHannaford Brothers Company1999-02-04Not applicableUs
IbuprofenTablet, film coated200 mg/1OralPublix Supermarkets, Inc.2006-05-03Not applicableUs
IbuprofenTablet200 mg/1OralLnk International, Inc.2002-04-08Not applicableUs
IbuprofenTablet200 mgOralPharmascience Inc2010-03-05Not applicableCanada
IbuprofenTablet, film coated200 mg/1OralLidl Us Llc2017-03-15Not applicableUs
IbuprofenTablet, coated200 mg/1OralShasun Pharmaceuticals Limited2011-03-28Not applicableUs
IbuprofenTablet, film coated200 mg/1OralCvs Health1988-05-24Not applicableUs
IbuprofenTablet, coated200 mg/1OralCvs Health2006-02-17Not applicableUs
IbuprofenTablet, film coated200 mg/1OralChain Drug Consortium1988-05-24Not applicableUs
IbuprofenTablet200 mgOralVita Health Products IncNot applicableNot applicableCanada
IbuprofenCapsule, liquid filled200 mg/1OralSelect Brand Dist.2010-03-13Not applicableUs
IbuprofenTablet, film coated200 mg/1OralSafeway1997-08-14Not applicableUs
IbuprofenTablet200 mg/1OralProficient Rx LP2011-01-27Not applicableUs
IbuprofenTablet, film coated200 mg/1OralFamily Dollar1988-05-24Not applicableUs
IbuprofenSuspension100 mg/5mLOralHyvee1997-09-30Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralKroger2012-07-12Not applicableUs
IbuprofenTablet, coated200 mg/1OralKroger1990-10-15Not applicableUs
IbuprofenTablet200 mg/1OralPolygen Pharmaceuticals Inc.2013-07-02Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralTopcare (Topco Associates Llc)2013-04-30Not applicableUs
IbuprofenTablet, coated200 mg/1OralWin Co Foods, Llc,2014-12-15Not applicableUs
IbuprofenSuspension50 mg/1.25mLOralMajor2000-01-08Not applicableUs
IbuprofenTablet, film coated200 mg/1OralShopko Stores Operating2013-09-09Not applicableUs
IbuprofenTablet200 mg/1OralWestern Family Foods2011-02-01Not applicableUs
IbuprofenSuspension / drops50 mg/1.25mLOralCvs Health2004-05-07Not applicableUs
IbuprofenSuspension50 mg/1.25mLOralRite Aid2004-05-06Not applicableUs
IbuprofenTablet200 mg/1OralEQUATE (Walmart Stores, Inc.)2015-05-04Not applicableUs
IbuprofenTablet, film coated200 mg/1OralCvs Health1999-03-01Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralTopcare (Topco Associates Llc)2015-05-31Not applicableUs
IbuprofenTablet200 mg/1OralMedline Industries2014-09-08Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralPreferred Plus (Kinray)2010-08-30Not applicableUs
IbuprofenTablet, film coated200 mg/1OralPharbest Pharmaceuticals, Inc.2011-01-18Not applicableUs
IbuprofenSuspension100 mg/5mLOralPhysicians Total Care, Inc.2000-09-12Not applicableUs
IbuprofenTablet, film coated200 mg/1OralHarmon Store Inc.1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralMedicine Shoppe International1988-03-15Not applicableUs
IbuprofenTablet, film coated200 mg/1OralLnk International, Inc.1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralRugby1988-05-24Not applicableUs
IbuprofenTablet, chewable100 mg/1OralWestern Family Foods2004-09-24Not applicableUs
IbuprofenTablet, coated200 mg/1OralAvema Pharma Solutions2013-08-01Not applicableUs
IbuprofenTablet, film coated200 mg/1OralSam's West, Inc1988-05-242016-10-22Us
IbuprofenCapsule, liquid filled200 mg/1OralCardinal Health (Leader) 372052012-04-092017-12-31Us
IbuprofenSuspension100 mg/5mLOralH.E.B.2016-03-01Not applicableUs
IbuprofenTablet, film coated200 mg/1OralKroger1993-02-28Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralGood Sense (Geiss, Destin & Dunn, Inc.)2013-04-23Not applicableUs
IbuprofenTablet200 mg/1OralMARKSANS PHARMA LIMITED2011-07-25Not applicableUs
IbuprofenTablet200 mg/1OralFamily Dollar (FAMILY WELLNESS)2015-05-04Not applicableUs
IbuprofenTablet, film coated200 mg/1OralWalgreen1999-03-01Not applicableUs
IbuprofenTablet, film coated200 mg/1OralH.J. Harkins Company1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralMeijer Distribution1988-05-24Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralDolgencorp, Inc. (Dollar General & Rexall)2012-05-17Not applicableUs
IbuprofenTablet200 mg/1OralSda Laboratories2011-01-27Not applicableUs
IbuprofenTablet, film coated256 mg/1OralMeijer Distribution2016-03-23Not applicableUs
IbuprofenTablet, coated200 mg/1OralTopcare (Topco Associates Llc)2014-04-30Not applicableUs
IbuprofenTablet, film coated200 mg/1OralGreat Lakes Wholesale, Marketing, and Sales, Inc.1988-05-24Not applicableUs
IbuprofenSuspension / drops50 mg/1.25mLOralMeijer Distribution2004-04-18Not applicableUs
IbuprofenTablet, film coated200 mg/1OralWalgreen2002-03-30Not applicableUs
IbuprofenTablet, coated200 mg/1OralMajor1994-08-16Not applicableUs
IbuprofenTablet, film coated200 mg/1OralShopko Stores Operating2013-09-09Not applicableUs
IbuprofenTablet200 mg/1OralWestern Family Foods2011-12-15Not applicableUs
IbuprofenTablet200 mg/1OralNucare Pharmaceuticals, Inc.2016-03-01Not applicableUs
IbuprofenSuspension / drops50 mg/1.25mLOralHannaford Brothers Company2005-03-16Not applicableUs
IbuprofenTablet, film coated200 mg/1OralDolgencorp1999-03-01Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralFred's2012-07-022016-12-31Us
IbuprofenCapsule, liquid filled200 mg/1OralPublix Supermarkets, Inc.2012-07-03Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralHumanwell Pura Cap Pharmaceutical (Wuhan), Ltd.2017-03-23Not applicableUs
IbuprofenTablet, film coated200 mg/1OralBetter Living Brands1999-03-01Not applicableUs
IbuprofenTablet, coated200 mg/1OralAAA Pharmaceutical, Inc.2012-12-04Not applicableUs
IbuprofenTablet, film coated200 mg/1OralHyvee1991-03-15Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralSuper Valu (Equaline)2012-01-10Not applicableUs
IbuprofenTablet, coated200 mg/1OralDolgencorp, Inc. (Dollar General & Rexall)2015-05-31Not applicableUs
IbuprofenTablet200 mg/1OralP & L Development, LLC2015-11-30Not applicableUs
IbuprofenTablet, film coated200 mg/1OralCostco Wholesale1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralSave A Lot Food Stores, Ltd.1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralWalgreen2009-01-21Not applicableUs
IbuprofenTablet, chewable100 mg/1OralRite Aid2010-06-25Not applicableUs
IbuprofenTablet, film coated200 mg/1OralCardinal Health1988-05-24Not applicableUs
IbuprofenTablet400 mgOral1466406 Ontario LtdNot applicableNot applicableCanada
IbuprofenTablet, film coated200 mg/1OralCvs Health2001-07-10Not applicableUs
IbuprofenTablet, film coated200 mg/1OralArmy + Air Force Exchange Service2002-03-30Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralHarmon Stores2014-08-31Not applicableUs
IbuprofenSuspension / drops50 mg/1.25mLOralHyvee2005-02-26Not applicableUs
IbuprofenTablet, sugar coated200 mg/1OralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2005-01-10Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralKroger2015-01-31Not applicableUs
IbuprofenTablet, film coated200 mg/1OralLake Erie Medical &Surgical Supply Dba Quality Care Products Llc2012-02-16Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralP And L Development Of New York Corporation (Ready In Case)2014-07-31Not applicableUs
IbuprofenTablet, film coated200 mg/1OralAi Ping Pharmaceutical, Inc.2017-05-08Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralDolgencorp, Inc. (Dollar General & Rexall)2016-02-29Not applicableUs
IbuprofenSuspension / drops50 mg/1.25mLOralKroger2010-05-15Not applicableUs
IbuprofenTablet200 mg/1OralNew World Imports2012-06-05Not applicableUs
IbuprofenTablet, film coated200 mg/1OralLnk International, Inc.1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralRebel Distributors2004-01-01Not applicableUs
IbuprofenTablet, coated200 mg/1OralShasun Pharmaceuticals Limited2011-04-28Not applicableUs
IbuprofenTablet200 mg/1OralSalado Sales, Inc.1988-05-24Not applicableUs
IbuprofenSuspension100 mg/5mLOralHyvee1999-03-05Not applicableUs
IbuprofenTablet, coated200 mg/1OralP And L Development Of New York Corporation (Ready In Case)2014-02-28Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralChain Drug Consortium2010-07-08Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralEQUATE (Walmart Stores, Inc.)2015-02-28Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralHumanwell Pura Cap Pharmaceutical (Wuhan), Ltd.2016-10-06Not applicableUs
IbuprofenTablet, film coated200 mg/1OralSafeway2012-08-09Not applicableUs
IbuprofenTablet, film coated200 mg/1OralPreferreed Pharmaceuticals Inc.2016-08-17Not applicableUs
IbuprofenTablet200 mg/1OralSda Laboratories2016-03-01Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralKroger2012-05-11Not applicableUs
IbuprofenTablet200 mg/1OralHART Health1987-06-03Not applicableUs
IbuprofenTablet200 mgOralApotex Corporation2015-12-23Not applicableCanada
IbuprofenTablet, film coated200 mg/1OralKroger2006-04-27Not applicableUs
IbuprofenTablet, coated200 mg/1OralPolygen Pharmaceuticals Inc.2012-06-05Not applicableUs
IbuprofenTablet, film coated200 mg/1OralTYA Pharmaceuticals1988-05-24Not applicableUs
IbuprofenTablet200 mg/1OralGranules India Limited2016-11-17Not applicableUs
IbuprofenTablet200 mg/1OralContract Pharmacy Services Pa2010-08-02Not applicableUs
IbuprofenTablet200 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-12-16Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralShopko Stores Operating2010-07-09Not applicableUs
IbuprofenTablet200 mg/1OralWestern Family Foods2011-02-01Not applicableUs
IbuprofenTablet200 mg/1OralWestern Family Foods2001-09-05Not applicableUs
IbuprofenTablet200 mg/1OralContract Pharmacal Corporation2014-01-15Not applicableUs
IbuprofenSuspension / drops50 mg/1.25mLOralH.E.B.2005-02-25Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralHealthy Accents (DZA Brands, LLC)2013-04-15Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralSuper Valu (Equaline)2010-07-09Not applicableUs
IbuprofenCapsule, coated200 mg/1OralNash Finch2002-04-08Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralEQUATE (Walmart Stores, Inc.)2016-12-31Not applicableUs
IbuprofenTablet, film coated200 mg/1OralDolgencorp1988-05-242017-02-25Us
IbuprofenSuspension / drops50 mg/1.25mLOralWalgreen2005-05-13Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralPublix Supermarkets, Inc.2013-04-30Not applicableUs
IbuprofenTablet, film coated200 mg/1OralMeijer Distribution2006-04-26Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralTarget Corporation.2010-08-01Not applicableUs
IbuprofenTablet, coated200 mg/1OralHannaford Brothers Company1995-06-01Not applicableUs
IbuprofenTablet, coated200 mg/1OralTopcare (Topco Associates Llc)2013-04-30Not applicableUs
IbuprofenTablet200 mg/1OralDiscount Drug Mart2013-06-20Not applicableUs
IbuprofenTablet, coated200 mg/1OralWin Co Foods, Llc,2014-12-15Not applicableUs
IbuprofenTablet, film coated200 mg/1OralWalgreen1988-05-24Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralWestern Family Foods2010-03-13Not applicableUs
IbuprofenTablet, film coated200 mg/1OralChain Drug Consortium2013-05-07Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralCardinal Health (Leader) 700002016-11-30Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralTarget Corporation.2015-02-28Not applicableUs
IbuprofenTablet, film coated200 mg/1OralL&R Distributors, Inc.2002-03-30Not applicableUs
IbuprofenTablet, film coated200 mg/1OralH.E.B.1989-02-15Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralHarris Teeter2015-02-28Not applicableUs
IbuprofenTablet200 mg/1OralMARKSANS PHARMA LIMITED2012-07-042015-12-29Us
IbuprofenTablet, film coated200 mg/1OralFred's1988-05-24Not applicableUs
IbuprofenTablet, chewable100 mg/1OralWalgreen2009-05-05Not applicableUs
IbuprofenTablet200 mg/1OralH.E.B.1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralPublix Supermarkets, Inc.1988-09-15Not applicableUs
IbuprofenSuspension100 mg/5mLOralLidl Us Llc2017-03-20Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralHyvee2013-04-13Not applicableUs
IbuprofenTablet, film coated200 mg/1OralClinical Solutions Wholsesale1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralCvs Health1988-05-24Not applicableUs
IbuprofenSuspension100 mg/5mLOralPerrigo New York Inc.2011-11-17Not applicableUs
IbuprofenTablet, film coated200 mg/1OralChain Drug Consortium2002-03-30Not applicableUs
IbuprofenTablet200 mg/1OralKinray2011-11-22Not applicableUs
IbuprofenTablet300 mgOralApotex CorporationNot applicableNot applicableCanada
IbuprofenTablet, film coated200 mg/1OralCvs Health1999-03-01Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralTime Cap Laboratories2015-12-23Not applicableUs
IbuprofenSuspension100 mg/5mLOralKroger2002-11-20Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralValu Merchandisers Company (Best Choice)2012-06-19Not applicableUs
IbuprofenTablet200 mg/1OralGranules India Limited2011-01-01Not applicableUs
IbuprofenTablet, coated200 mg/1OralAAA Pharmaceutical, Inc.2012-12-04Not applicableUs
IbuprofenTablet, film coated200 mg/1OralArmy + Air Force Exchange Service2002-04-08Not applicableUs
IbuprofenTablet, film coated200 mg/1OralCardinal Health1999-03-01Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralHyvee2015-01-31Not applicableUs
IbuprofenTablet200 mg/1OralKinray2016-03-01Not applicableUs
IbuprofenTablet, film coated200 mg/1OralAi Ping Pharmaceutical, Inc.2017-05-08Not applicableUs
IbuprofenTablet, film coated200 mg/1OralTime Cap Laboratories2016-03-22Not applicableUs
IbuprofenTablet, chewable100 mg/1OralKroger2004-05-10Not applicableUs
IbuprofenTablet200 mg/1OralNew World Imports2010-09-10Not applicableUs
IbuprofenTablet, film coated200 mg/1OralCvs Health2006-04-27Not applicableUs
IbuprofenTablet200 mg/1OralNash Finch1988-05-242018-09-09Us
IbuprofenCapsule, liquid filled200 mg/1OralCare One (American Sales Company)2013-03-15Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralEQUATE (Walmart Stores, Inc.)2012-12-11Not applicableUs
IbuprofenTablet, film coated200 mg/1OralTime Cap Laboratories2016-11-16Not applicableUs
IbuprofenTablet200 mg/1OralMedline Industries2015-04-21Not applicableUs
IbuprofenTablet, film coated200 mg/1OralRemedy Repack2011-10-192017-04-14Us
IbuprofenSuspension100 mg/5mLOralAtlantic Biologicals Corps.1999-02-07Not applicableUs
IbuprofenTablet, coated200 mg/1OralRugby2011-03-01Not applicableUs
IbuprofenTablet, film coated200 mg/1OralNucare Pharmaceuticals, Inc.2004-01-01Not applicableUs
IbuprofenTablet, coated200 mg/1OralMedicine Shoppe International1990-02-15Not applicableUs
IbuprofenTablet, film coated200 mg/1OralLnk International, Inc.1999-03-01Not applicableUs
IbuprofenTablet, film coated200 mg/1OralWestern Family Foods2006-05-31Not applicableUs
IbuprofenTablet, coated200 mg/1OralAvema Pharma Solutions2013-08-01Not applicableUs
IbuprofenTablet, film coated200 mg/1OralMajor2004-03-11Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralHealthy Accents (DZA Brands, LLC)2012-12-11Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralQuality Choice (Chain Drug Marketing Association, Inc.)2013-03-11Not applicableUs
IbuprofenTablet200 mg/1OralKroger2015-06-30Not applicableUs
IbuprofenTablet, coated200 mg/1OralGood Sense (Geiss, Destin & Dunn, Inc.)2013-04-13Not applicableUs
IbuprofenTablet200 mg/1OralMARKSANS PHARMA LIMITED2015-11-06Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralSuper Valu (Equaline)2010-08-24Not applicableUs
IbuprofenTablet, coated200 mg/1OralFamily Dollar (FAMILY WELLNESS)2014-06-30Not applicableUs
IbuprofenTablet, film coated200 mg/1OralAidarex Pharmaceuticals LLC1994-08-16Not applicableUs
IbuprofenSuspension100 mg/5mLOralH.J. Harkins Company1999-02-07Not applicableUs
IbuprofenCapsule, coated200 mg/1OralNash Finch1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralMeijer Distribution2002-04-08Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralDolgencorp, Inc. (Dollar General & Rexall)2010-07-07Not applicableUs
IbuprofenTablet, film coated200 mg/1OralLnk International, Inc.1999-03-02Not applicableUs
IbuprofenTablet, film coated200 mg/1OralHarmon Store Inc.1999-03-01Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralWin Co Foods, Llc,2014-12-31Not applicableUs
IbuprofenTablet, film coated200 mg/1OralMajor1988-05-24Not applicableUs
IbuprofenTablet, coated200 mg/1OralShopko Stores Operating2013-09-12Not applicableUs
IbuprofenTablet200 mg/1OralWestern Family Foods2012-07-05Not applicableUs
IbuprofenTablet, chewable100 mg/1OralHannaford Brothers Company2004-06-24Not applicableUs
IbuprofenTablet200 mg/1OralTarget Corporation.2011-09-14Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralCardinal Health (Leader)2012-12-11Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralFred's2013-04-13Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralPublix Supermarkets, Inc.2012-07-03Not applicableUs
IbuprofenTablet, coated200 mg/1OralP & L Development, LLC2017-03-31Not applicableUs
IbuprofenTablet, film coated200 mg/1OralBetter Living Brands1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralH.E.B.2006-07-04Not applicableUs
IbuprofenTablet, film coated200 mg/1OralGericare Pharmaceuticals2004-01-01Not applicableUs
IbuprofenTablet, film coated200 mg/1OralCardinal Health1999-03-01Not applicableUs
IbuprofenTablet, coated200 mg/1OralHyvee1989-07-15Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralNash Finch Company (Our Family)2013-04-30Not applicableUs
IbuprofenTablet, film coated200 mg/1OralSupervalu2002-03-30Not applicableUs
IbuprofenTablet, coated200 mg/1OralP & L Development, LLC2014-11-30Not applicableUs
IbuprofenTablet, film coated200 mg/1OralCostco Wholesale1999-03-02Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralMeijer2015-02-28Not applicableUs
IbuprofenSuspension100 mg/5mLOralCvs Health2009-06-30Not applicableUs
IbuprofenSuspension100 mg/5mLOralRite Aid2002-05-10Not applicableUs
IbuprofenTablet, film coated200 mg/1OralFred's2002-04-08Not applicableUs
IbuprofenTablet, coated200 mg/1OralRemedy Repack2015-03-072017-03-17Us
IbuprofenCapsule, liquid filled200 mg/1OralSafeway2010-07-06Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralSunmark (Mckesson)2010-07-09Not applicableUs
IbuprofenTablet, coated200 mg/1OralVelocity Pharma2012-07-01Not applicableUs
IbuprofenTablet, film coated200 mg/1OralL&R Distributors, Inc.1988-05-24Not applicableUs
IbuprofenTablet, film coated200 mg/1OralDolgencorp1999-03-02Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralWalgreens2014-08-31Not applicableUs
IbuprofenTablet100 mg/1OralMeijer Distribution2009-05-27Not applicableUs
IbuprofenTablet, chewable100 mg/1OralPublix Supermarkets, Inc.2004-10-28Not applicableUs
IbuprofenTablet, film coated200 mg/1OralLnk International, Inc.1999-03-02Not applicableUs
IbuprofenTablet200 mgOralPharmascience Inc2010-03-05Not applicableCanada
IbuprofenTablet, coated200 mg/1OralShasun Pharmaceuticals Limited2011-04-04Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralCvs Health2014-07-31Not applicableUs
IbuprofenTablet, film coated200 mg/1OralCardinal Health1999-03-01Not applicableUs
IbuprofenSuspension50 mg/1.25mLOralPerrigo New York Inc.2014-04-09Not applicableUs
IbuprofenTablet, chewable100 mg/1OralCvs Health2004-05-07Not applicableUs
IbuprofenTablet, film coated200 mg/1OralChain Drug Consortium2002-04-08Not applicableUs
IbuprofenTablet200 mgOralVita Health Products Inc1998-10-062008-08-05Canada
IbuprofenTablet, coated200 mg/1OralASSURED / DOLLAR TREE (Greenbrier International, Inc.)2016-07-31Not applicableUs
IbuprofenTablet400 mgOralPerrigo InternationalNot applicableNot applicableCanada
IbuprofenTablet200 mg/1OralApotheca, Inc.2009-09-16Not applicableUs
IbuprofenTablet400 mgOralPharmascience IncNot applicableNot applicableCanada
IbuprofenTablet, film coated200 mg/1OralFamily Dollar1988-05-242017-04-01Us
IbuprofenCapsule, liquid filled200 mg/1OralCvs Health2012-09-24Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralKroger2012-07-12Not applicableUs
IbuprofenTablet, coated200 mg/1OralChain Drug Marketing Association2012-08-27Not applicableUs
IbuprofenTablet200 mg/1OralKroger1988-01-15Not applicableUs
IbuprofenTablet, coated200 mg/1OralPolygen Pharmaceuticals Inc.2012-06-05Not applicableUs
IbuprofenTablet200 mg/1OralGranules India Limited2016-11-17Not applicableUs
IbuprofenTablet, film coated200 1/1OralAdvanced First Aid, Inc.2015-04-09Not applicableUs
IbuprofenTablet, film coated200 mg/1OralH.E.B.1999-03-01Not applicableUs
IbuprofenSuspension100 mg/5mLOralMajor1999-02-07Not applicableUs
IbuprofenTablet, coated200 mg/1OralWestern Family Foods2001-09-05Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralBJWC2012-09-01Not applicableUs
IbuprofenTablet200 mg/1OralContract Pharmacal Corporation2014-01-15Not applicableUs
IbuprofenTablet, coated200 mg/1OralHealthy Accents (DZA Brands, LLC)2015-05-04Not applicableUs
IbuprofenCapsule, liquid filled200 mg/1OralKroger2010-07-01Not applicableUs
Ibuprofen - Tab 200mgTablet200 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1998-02-052002-07-31Canada
Ibuprofen (nsaid) Pain Releiver/ Fever ReducerTablet200 mg/1OralAmneal Pharmaceuticals2009-12-16Not applicableUs
Ibuprofen (nsaid) Pain Releiver/ Fever ReducerTablet200 mg/1OralRebel Distributors2009-12-16Not applicableUs
Ibuprofen (nsaid) Pain Releiver/ Fever ReducerTablet200 mg/1OralAmneal Pharmaceuticals2009-12-16Not applicableUs
Ibuprofen 200Tablet, coated200 mg/1OralWalgreen2002-04-08Not applicableUs
Ibuprofen 200 mgTablet200 mgOralPendopharm Division Of De Pharmascience Inc2007-06-012013-05-31Canada
Ibuprofen 200 mgTablet200 mgOralPharmetics (2011) Inc.2005-10-12Not applicableCanada
Ibuprofen CapletCapsule200 mg/1OralChain Drug Consortium2014-11-04Not applicableUs
Ibuprofen CapletsTablet400 mgOralPharmetics (2011) Inc.2009-01-28Not applicableCanada
Ibuprofen CapletsTablet200 mgOralVita Health Products Inc2016-07-04Not applicableCanada
Ibuprofen CapletsTablet400 mgOralApotex Corporation2015-12-23Not applicableCanada
Ibuprofen CapletsTablet200 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ibuprofen CapletsTablet200 mgOralApotex Corporation2016-02-26Not applicableCanada
Ibuprofen Caplets 200 mgTablet200 mgOralVita Health Products Inc2006-04-07Not applicableCanada
Ibuprofen Caplets 200 mgTablet200 mgOralPerrigo InternationalNot applicableNot applicableCanada
Ibuprofen Capsules, 200mgCapsule200 mgOralBionpharma IncNot applicableNot applicableCanada
Ibuprofen Capsules, 400mgCapsule400 mgOralBionpharma Inc2010-11-05Not applicableCanada
Ibuprofen ChildrensSuspension100 mg/5mLOralWalgreen2015-06-16Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralMajor2002-04-03Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralSafeway1999-01-18Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralHyvee2002-05-13Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralRite Aid1999-01-08Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralMedicine Shoppe International1999-01-09Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralPreferreed Pharmaceuticals Inc.2012-04-23Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralHyvee2002-04-01Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralWestern Family Foods2002-10-14Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralWalgreen1999-03-11Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralKroger1999-01-19Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralCvs Health2002-09-04Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralMeijer Distribution1999-01-05Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralCvs Health1999-01-07Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralMeijer Distribution2002-03-19Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralKroger2002-11-20Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralWalgreen2002-03-04Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralWalgreen2002-03-25Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralHannaford Brothers Company2009-05-06Not applicableUs
Ibuprofen ChildrensSuspension100 mg/5mLOralH.E.B.2002-06-10Not applicableUs
Ibuprofen DaytimeCapsule200 mgOralVita Health Products IncNot applicableNot applicableCanada
Ibuprofen Dye FreeTablet, film coated200 mg/1OralCvs Health2004-03-11Not applicableUs
Ibuprofen Dye-freeTablet, film coated200 mg/1OralWalmart Stores2004-03-11Not applicableUs
Ibuprofen Extra Strength CapletsTablet400 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ibuprofen Extra Strength CapletsTablet400 mgOralVita Health Products Inc2011-08-05Not applicableCanada
Ibuprofen Fast Relief Medicine for PainTablet200 mg/1OralAllegiant Health2014-12-19Not applicableUs
Ibuprofen IbTablet, coated200 mg/1OralWin Co Foods, Llc,2014-12-15Not applicableUs
Ibuprofen IbTablet, film coated200 mg/1OralHyvee2006-05-21Not applicableUs
Ibuprofen IbTablet, coated200 mg/1OralChain Drug Marketing Association2007-05-11Not applicableUs
Ibuprofen IbTablet, coated200 mg/1OralChain Drug Marketing Association2014-05-14Not applicableUs
Ibuprofen IbTablet, coated200 mg/1OralHyvee2006-05-14Not applicableUs
Ibuprofen IbTablet, coated200 mg/1OralWin Co Foods, Llc,2014-12-15Not applicableUs
Ibuprofen IbTablet, coated200 mg/1OralChain Drug Marketing Association2007-05-11Not applicableUs
Ibuprofen IbTablet, film coated200 mg/1OralFamily Dollar Services2002-04-08Not applicableUs
Ibuprofen IbTablet, coated200 mg/1OralChain Drug Marketing Association2014-05-14Not applicableUs
Ibuprofen Immediate ReleaseTablet, coated200 mg/1OralDiscount Drug Mart2014-12-22Not applicableUs
Ibuprofen Immediate ReleaseTablet, coated200 mg/1OralStrides Pharma Inc.2011-04-04Not applicableUs
Ibuprofen Immediate ReleaseTablet, coated200 mg/1OralDiscount Drug Mart2014-12-22Not applicableUs
Ibuprofen Immediate ReleaseTablet, coated200 mg/1OralStrides Pharma Inc.2016-08-26Not applicableUs
Ibuprofen Immediate ReleaseTablet, coated200 mg/1OralStrides Pharma Inc.2011-04-04Not applicableUs
Ibuprofen Immediate ReleaseTablet, coated200 mg/1OralStrides Pharma Inc.2016-08-26Not applicableUs
Ibuprofen InfantsSuspension50 mg/1.25mLOralH.E.B.2002-06-18Not applicableUs
Ibuprofen InfantsSuspension50 mg/1.25mLOralMeijer Distribution2000-03-17Not applicableUs
Ibuprofen InfantsSuspension50 mg/1.25mLOralWestern Family Foods2000-08-16Not applicableUs
Ibuprofen InfantsSuspension50 mg/1.25mLOralWalgreen2001-04-13Not applicableUs
Ibuprofen InfantsSuspension50 mg/1.25mLOralKroger2002-11-20Not applicableUs
Ibuprofen InfantsSuspension50 mg/1.25mLOralHyvee2000-09-03Not applicableUs
Ibuprofen JuniorTablet, chewable100 mg/1OralPhysicians Total Care, Inc.2007-10-16Not applicableUs
Ibuprofen Junior StrengthTablet, chewable100 mg/1OralWalgreen2012-12-18Not applicableUs
Ibuprofen Junior StrengthTablet, chewable100 mg/1OralMeijer Distribution2004-05-02Not applicableUs
Ibuprofen Liqui-gelsCapsule, liquid filled200 mg/1OralAllegiant Health2014-12-22Not applicableUs
Ibuprofen Liquid CapsulesCapsule200 mgOralVita Health Products Inc2011-03-31Not applicableCanada
Ibuprofen Liquid Filled CapsulesCapsule200 mgOralApotex Corporation2006-11-07Not applicableCanada
Ibuprofen Liquid Gel CapsulesCapsule200 mgOralApotex Corporation2016-09-15Not applicableCanada
Ibuprofen Menstrual Pain ReliefTablet400 mgOralApotex Corporation2009-03-03Not applicableCanada
Ibuprofen Muscle and JointTablet400 mgOralPharmascience Inc2012-09-12Not applicableCanada
Ibuprofen Oral Suspension USPSuspension100 mgOralApotex CorporationNot applicableNot applicableCanada
Ibuprofen Pain Releiver/ Fever ReducerTablet200 mg/1OralAmneal Pharmaceuticals of New York Llc2009-12-16Not applicableUs
Ibuprofen Pain Releiver/ Fever ReducerTablet200 mg/1OralAmneal Pharmaceuticals of New York Llc2009-12-16Not applicableUs
Ibuprofen Pain Reliever/ Fever ReducerTablet200 mg/1OralChain Drug Consortium2014-12-30Not applicableUs
Ibuprofen Pain Reliever/ Fever ReducerSuspension100 mg/5mLOralAmneal Pharmaceuticals2011-11-12Not applicableUs
Ibuprofen Pain Reliever/fever ReducerCapsule, liquid filled200 mg/1OralAmneal Pharmaceuticals of New York Llc2011-12-23Not applicableUs
Ibuprofen Pain Reliever/fever ReducerTablet200 mg/1OralAllegiant Health2014-12-22Not applicableUs
Ibuprofen Pain Reliever/fever ReducerCapsule, liquid filled200 mg/1OralAmneal Pharmaceuticals2013-03-29Not applicableUs
Ibuprofen SodiumTablet, film coated256 mg/1OralWalgreen2016-01-13Not applicableUs
Ibuprofen SodiumTablet, film coated256 mg/1OralWalgreen2016-01-13Not applicableUs
Ibuprofen SoftgelsCapsule, liquid filled200 mg/1OralAmerisource Bergen Drug Corporation (Good Neighbor Pharmacy) 243852010-07-08Not applicableUs
Ibuprofen Tab 200mgTablet200 mgOralPro Doc Limitee1985-12-312010-07-13Canada
Ibuprofen Tab 300mgTablet300 mgOralPro Doc Limitee1985-12-312010-07-13Canada
Ibuprofen Tab 400mgTablet400 mgOralPro Doc Limitee1985-12-31Not applicableCanada
Ibuprofen TabletsTablet200 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ibuprofen TabletsTablet200 mgOralVita Health Products Inc2016-09-06Not applicableCanada
Ibuprofen Tablets 200 mgTablet200 mgOralVita Health Products Inc2005-11-16Not applicableCanada
Ibuprofen Tablets 200 mgTablet200 mgOralPerrigo InternationalNot applicableNot applicableCanada
IbutabTablet200 mg/1OralZee Medical Inc2012-06-12Not applicableUs
Infant's Motrin Suspension DropsSuspension40 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1998-10-14Not applicableCanada
Infants AdvilSuspension / drops50 mg/1.25mLOralPfizer1998-01-30Not applicableUs
Infants Dye-free IbuprofenSuspension50 mg/1.25mLOralWalgreen2010-05-24Not applicableUs
Infants IbuprofenLiquid50 mg/1.25mLOralFred's2012-02-22Not applicableUs
Infants IbuprofenLiquid50 mg/1.25mLOralCvs Health2010-12-01Not applicableUs
Infants IbuprofenLiquid50 mg/1.25mLOralL&R Distributors, Inc.2009-10-02Not applicableUs
Infants IbuprofenLiquid50 mg/1.25mLOralNash Finch Company (Our Family)2014-03-19Not applicableUs
Infants IbuprofenSuspension50 mg/1.25mLOralCvs Health1999-11-08Not applicableUs
Infants IbuprofenSuspension50 mg/1.25mLOralFamily Dollar Services2012-02-22Not applicableUs
Infants IbuprofenSuspension50 mg/1.25mLOralChain Drug Marketing Association2009-11-01Not applicableUs
Infants IbuprofenLiquid50 mg/1.25mLOralRite Aid2010-05-17Not applicableUs
Infants IbuprofenSuspension50 mg/1.25mLOralActavis Pharma Company2010-05-20Not applicableUs
Infants IbuprofenSuspension50 mg/1.25mLOralKinray2010-07-01Not applicableUs
Infants IbuprofenLiquid50 mg/1.25mLOralValue Merchandisers2009-10-02Not applicableUs
Infants IbuprofenLiquid50 mg/1.25mLOralWalmart Stores2012-05-21Not applicableUs
Infants IbuprofenSuspension / drops50 mg/1.25mLOralShopko Stores Operating2013-07-30Not applicableUs
Infants MotrinSuspension / drops50 mg/1.25mLOralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2004-06-01Not applicableUs
Jamp-ibuprofenTablet400 mgOralJamp Pharma Corporation2014-01-07Not applicableCanada
Junior Strength AdvilTablet, chewable100 mg/1OralPfizer2011-06-01Not applicableUs
Junior Strength AdvilTablet, coated100 mg/1OralWyeth Consumer Healthcare Llc2011-06-21Not applicableUs
Junior Strength AdvilTablet, chewable100 mgOralPfizer Laboratories Div Pfizer Inc.2003-03-31Not applicableCanada
Junior Strength AdvilTablet, chewable100 mg/1OralAvera Mc Kennan Hospital2015-04-22Not applicableUs
Junior Strength Advil Fever From Colds Or FluTablet, chewable100 mgOralPfizer Laboratories Div Pfizer Inc.2009-11-05Not applicableCanada
Junior Strength IbuprofenTablet, chewable100 mg/1OralKroger2017-04-25Not applicableUs
Junior Strength IbuprofenTablet, chewable100 mg/1OralH.E.B.2010-09-01Not applicableUs
Junior Strength IbuprofenTablet, chewable100 mg/1OralShopko Stores Operating2013-07-30Not applicableUs
Junior Strength Motrin CapletsTablet100 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1999-09-202016-01-22Canada
Junior Strength Motrin Chewable Tablet 100mgTablet100 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2001-02-122003-07-15Canada
Junior Strength Motrin Chewable TabletsTablet100 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2003-05-14Not applicableCanada
Kirkland Signature IbuprofenTablet, film coated200 mg/1OralCostco Wholesale2003-06-25Not applicableUs
Kirkland Signature Ibuprofen IbTablet, film coated200 mg/1OralCostco Wholesale2007-06-22Not applicableUs
Leader Childrens IbuprofenSuspension100 mg/5mLOralCardinal Health2002-04-25Not applicableUs
Leader Childrens IbuprofenSuspension100 mg/5mLOralCardinal Health2002-05-08Not applicableUs
Leader Childrens IbuprofenSuspension100 mg/5mLOralCardinal Health2017-03-28Not applicableUs
Leader Childrens IbuprofenSuspension100 mg/5mLOralCardinal Health2014-03-05Not applicableUs
Leader Childrens IbuprofenSuspension100 mg/5mLOralCardinal Health2016-11-04Not applicableUs
Leader IbuprofenSuspension50 mg/1.25mLOralCardinal Health2017-06-01Not applicableUs
Leader IbuprofenTablet, coated200 mg/1OralCardinal Health2016-11-30Not applicableUs
Leader IbuprofenTablet, film coated200 mg/1OralCardinal Health1990-05-15Not applicableUs
Leader IbuprofenTablet, coated200 mg/1OralCardinal Health2015-03-24Not applicableUs
Leader IbuprofenSuspension100 mg/5mLOralCardinal Health2002-05-08Not applicableUs
Leader IbuprofenTablet, chewable100 mg/1OralCardinal Health1990-11-15Not applicableUs
Leader IbuprofenTablet, film coated200 mg/1OralCardinal Health1990-10-15Not applicableUs
Leader IbuprofenTablet, chewable100 mg/1OralCardinal Health2017-04-20Not applicableUs
Leader IbuprofenTablet, coated200 mg/1OralCardinal Health2017-06-01Not applicableUs
Leader IbuprofenTablet, coated200 mg/1OralCardinal Health1990-05-15Not applicableUs
Leader IbuprofenSuspension100 mg/5mLOralCardinal Health2002-04-25Not applicableUs
Leader IbuprofenSuspension100 mg/5mLOralCardinal Health2017-05-01Not applicableUs
Leader IbuprofenTablet, chewable100 mg/1OralCardinal Health2017-04-21Not applicableUs
Leader IbuprofenTablet, chewable100 mg/1OralCardinal Health2004-05-28Not applicableUs
Leader IbuprofenTablet, chewable100 mg/1OralAvera Mc Kennan Hospital2015-09-04Not applicableUs
Leader IbuprofenSuspension100 mg/5mLOralCardinal Health1999-01-28Not applicableUs
Leader IbuprofenTablet, film coated200 mg/1OralCardinal Health2016-11-30Not applicableUs
Leader IbuprofenTablet, coated200 mg/1OralCardinal Health2006-03-10Not applicableUs
Leader IbuprofenTablet, film coated200 mg/1OralCardinal Health2015-03-13Not applicableUs
Leader IbuprofenSuspension100 mg/5mLOralCardinal Health2017-04-05Not applicableUs
Leader IbuprofenSuspension100 mg/5mLOralCardinal Health2008-10-16Not applicableUs
Leader IbuprofenSuspension / drops50 mg/1.25mLOralCardinal Health2004-07-19Not applicableUs
Leader Ibuprofen 200Tablet200 mg/1OralCardinal Health2014-07-23Not applicableUs
Leader Ibuprofen ChildrensSuspension100 mg/5mLOralCardinal Health2002-04-25Not applicableUs
Leader Ibuprofen InfantsSuspension50 mg/1.25mLOralCardinal Health1999-09-30Not applicableUs
Leader Infants IbuprofenSuspension / drops50 mg/1.25mLOralCardinal Health2017-06-07Not applicableUs
Lil Drug Store IbuprofenTablet200 mg/1OralLil' Drug Store Products, Inc.2015-01-10Not applicableUs
Lil Drug Store IbuprofenTablet200 mg/1OralLil' Drug Store Products, Inc.2011-01-27Not applicableUs
Major Childrens IbuprofenSuspension100 mg/5mLOralMajor2000-02-01Not applicableUs
Medi-first IbuprofenTablet, coated200 mg/1OralUnifirst First Aid2014-11-17Not applicableUs
Medi-first IbuprofenTablet, film coated200 mg/1OralUnifirst First Aid2016-02-01Not applicableUs
Medi-first IbuprofenTablet, film coated200 mg/1OralUnifirst First Aid2008-12-30Not applicableUs
Medi-first Plus IbuprofenTablet, film coated200 mg/1OralUnifirst First Aid2008-12-30Not applicableUs
Medi-first Plus IbuprofenTablet, coated200 mg/1OralUnifirst First Aid2014-11-17Not applicableUs
Medi-first Plus IbuprofenTablet, coated200 mg/1OralUnifirst First Aid2016-02-01Not applicableUs
Medipren Tab 200mgTablet200 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1989-12-311998-08-10Canada
Medique I-prinTablet, film coated200 mg/1OralUnifirst First Aid2008-12-30Not applicableUs
Medique IprinTablet, coated200 mg/1OralUnifirst First Aid2016-02-01Not applicableUs
Medique IprinTablet, coated200 mg/1OralUnifirst First Aid2014-11-17Not applicableUs
Members Mark IbuprofenTablet, film coated200 mg/1OralSam's West, Inc2015-05-18Not applicableUs
MidolCapsule, liquid filled200 mg/1OralBayer Health Care Llc, Consumer Care2009-05-18Not applicableUs
Moore Medical Llc IbuprofenTablet, film coated200 mg/1OralMoore Medical2008-12-30Not applicableUs
Moorebrand IbuprofenTablet, coated200 mg/1OralMoore Medical2014-11-172016-02-17Us
Moorebrand IbuprofenTablet, film coated200 mg/1OralMoore Medical2016-02-01Not applicableUs
Motrin 200mgTablet200 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1972-12-31Not applicableCanada
Motrin 300mgTablet300 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2002-05-15Not applicableCanada
Motrin 400mgTablet400 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2002-05-15Not applicableCanada
Motrin CapletTablet200 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1996-07-172016-01-22Canada
Motrin GelcapsTablet200 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1998-02-12Not applicableCanada
Motrin IbCapsule, liquid filled200 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2015-01-26Not applicableUs
Motrin IbTablet, film coated200 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2016-07-01Not applicableUs
Motrin IbTablet, film coated200 mg/1OralMechanical Servants, Llc2000-08-01Not applicableUs
Motrin IbTablet, coated200 mg/1OralLil' Drug Store Products, Inc.2010-05-10Not applicableUs
Motrin IbTablet200 mg/1OralNavajo Manuracturing Company2016-09-22Not applicableUs
Motrin IbTablet, film coated200 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2000-08-01Not applicableUs
Motrin Ib Caplet/tab 200mgTablet200 mgOralUpjohn1989-12-311996-09-10Canada
Motrin Ib Caplets 200mgTablet200 mgOralUpjohn1993-12-311996-09-10Canada
Motrin Ib Menstrual PainTablet200 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Motrin InfantsSuspension / drops50 mg/1.25mLOralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2001-09-01Not applicableUs
Motrin Liquid Gels 200mgCapsule200 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2007-10-31Not applicableCanada
Motrin Tablets 300mgTablet300 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1975-12-312002-05-15Canada
Motrin Tablets 400mgTablet400 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1978-12-312002-05-14Canada
Muscle & JointTablet400 mgOralVita Health Products Inc2013-05-16Not applicableCanada
Novo-profenTablet400 mgOralTeva1985-12-31Not applicableCanada
Novo-profenTablet200 mgOralTeva1985-12-31Not applicableCanada
Novo-profenTablet300 mgOralTeva1985-12-31Not applicableCanada
Nu-ibuprofen Tab 300mgTablet300 mgOralNu Pharm Inc1993-12-312012-09-04Canada
Nu-ibuprofen Tab 400mgTablet400 mgOralNu Pharm Inc1993-12-312012-09-04Canada
Nuprin Immediate ReleaseTablet, coated200 mg/1OralStrides Arcolab Limited2015-12-16Not applicableUs
Otis Clapp UltraprinTablet, coated200 mg/1OralUnifirst First Aid2016-02-01Not applicableUs
Otis Clapp UltraprinTablet, film coated200 mg/1OralUnifirst First Aid2008-12-30Not applicableUs
Otis Clapp UltraprinTablet, coated200 mg/1OralUnifirst First Aid2014-11-17Not applicableUs
Pain ReliefTablet, coated200 mg/1OralP & L Development Of New York Corporation2012-09-28Not applicableUs
Pain ReliefTablet200 mg/1OralP & L Development Of New York Corporation2013-11-30Not applicableUs
Pain ReliefTablet200 mg/1OralSelect Corporation2012-10-15Not applicableUs
Pain ReliefTablet, coated200 mg/1OralP & L Development Of New York Corporation2012-08-13Not applicableUs
Pain Relief Anti InflammatoryTablet200 mg/1OralSelect Corporation2012-10-15Not applicableUs
Pain Relief IbuprofenTablet, film coated200 mg/1OralRite Aid2002-03-30Not applicableUs
Pain Relief IbuprofenTablet200 mg/1OralRite Aid1988-05-24Not applicableUs
Pamprin Ibuprofen FormulaTablet400 mgOralApotex Corporation2007-06-22Not applicableCanada
Pediacare ChildrensSuspension100 mg/5mLOralMedtech Laboratories, Inc.2011-01-12Not applicableUs
Pediacare InfantsLiquid50 mg/1.25mLOralMedtech Laboratories, Inc.2011-10-15Not applicableUs
Pendo-ibuprofenTablet200 mgOralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Pendo-ibuprofen (200mg Caplet)Tablet200 mgOralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Pendo-ibuprofen EsTablet400 mgOralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Physicians Care IbuprofenTablet, coated200 mg/1OralAcme United Corporation2016-02-01Not applicableUs
Physicians Care IbuprofenTablet, film coated200 mg/1OralAcme United Corporation2016-02-01Not applicableUs
Physicianscare IbuprofenTablet200 mg/1OralAcme United Corporation2011-10-072017-02-25Us
PMS-ibuprofenTablet200 mgOralPharmascience IncNot applicableNot applicableCanada
PMS-ibuprofenTablet400 mgOralPharmascience Inc2008-07-09Not applicableCanada
PMS-ibuprofen (caplets)Tablet200 mgOralPharmascience IncNot applicableNot applicableCanada
Preferred Plus IbuprofenTablet, film coated200 mg/1OralKinray2013-05-11Not applicableUs
Preferred Plus Ibuprofen 200Tablet200 mg/1OralKinray2013-06-26Not applicableUs
Premier Value Infants IbuprofenSuspension50 mg/1.25mLOralChain Drug Consortium2009-12-01Not applicableUs
ProbufenTablet400 mg/537mgOralSAMSUNG PHARM IND. CO., LTD.2011-12-01Not applicableUs
Profen IbSuspension / drops50 mg/1.25mLOralPublix Supermarkets, Inc.2015-02-19Not applicableUs
Profen IbSuspension100 mg/5mLOralPublix Supermarkets, Inc.2003-11-18Not applicableUs
Profen Ib ChildrensSuspension100 mg/5mLOralPublix Supermarkets, Inc.2001-09-13Not applicableUs
Profen Ib InfantsSuspension50 mg/1.25mLOralPublix Supermarkets, Inc.2001-06-29Not applicableUs
ProprinalTablet, sugar coated200 mg/1OralNor Med1990-06-01Not applicableUs
Quality Choice Ibuprofen 200Tablet200 mg/1OralChain Drug Marketing Association2014-07-23Not applicableUs
Redicare IbuprofenTablet, film coated200 1/2001OralRedicare Llc2017-02-01Not applicableUs
Regular IbuprofenTablet200 mgOralTevaNot applicableNot applicableCanada
Rexall IbuprofenTablet, chewable100 mg/1OralDolgencorp2010-09-14Not applicableUs
Rexall IbuprofenSuspension100 mg/5mLOralDolgencorp2010-08-19Not applicableUs
Rexall IbuprofenTablet, film coated200 mg/1OralDolgencorp2012-09-06Not applicableUs
Rexall IbuprofenTablet, film coated200 mg/1OralDolgencorp2013-08-07Not applicableUs
Rexall IbuprofenTablet, film coated200 mg/1OralDolgencorp2012-08-24Not applicableUs
Rx Act IbuprofenTablet, film coated200 mg/1OralH.E.B.2006-07-04Not applicableUs
Rx Act IbuprofenSuspension100 mg/5mLOralH.E.B.2002-06-19Not applicableUs
Rx Act IbuprofenTablet, film coated200 mg/1OralH.E.B.1994-02-04Not applicableUs
Rx Act Ibuprofen ChildrensSuspension100 mg/5mLOralH.E.B.1999-01-06Not applicableUs
Rx Act Ibuprofen ChildrensSuspension100 mg/5mLOralH.E.B.2002-06-10Not applicableUs
Shoprite Childrens IbuprofenSuspension100 mg/5mLOralWakfern Food Corporation2013-06-20Not applicableUs
Shoprite Childrens IbuprofenSuspension100 mg/5mLOralWakfern Food Corporation2013-08-19Not applicableUs
Shoprite IbuprofenTablet, film coated200 mg/1OralWakfern Food Corporation2013-08-06Not applicableUs
Shoprite IbuprofenSuspension100 mg/5mLOralWakfern Food Corporation2014-05-12Not applicableUs
Shoprite IbuprofenTablet, coated200 mg/1OralWakfern Food Corporation2013-08-06Not applicableUs
Shoprite Ibuprofen IbTablet, coated200 mg/1OralWakfern Food Corporation2013-08-06Not applicableUs
Shoprite Ibuprofen IbTablet, chewable100 mg/1OralWakfern Food Corporation2013-07-02Not applicableUs
Shoprite Ibuprofen IbTablet, film coated200 mg/1OralWakfern Food Corporation2013-08-06Not applicableUs
Shoprite Infants IbuprofenSuspension / drops50 mg/1.25mLOralWakfern Food Corporation2013-06-17Not applicableUs
Signature Care Childrens IbuprofenSuspension100 mg/5mLOralSafeway2015-09-04Not applicableUs
Signature Care Childrens IbuprofenSuspension100 mg/5mLOralSafeway2015-09-01Not applicableUs
Signature Care Childrens IbuprofenSuspension100 mg/5mLOralSafeway2015-09-01Not applicableUs
Signature Care IbuprofenTablet, film coated200 mg/1OralSafeway2015-09-14Not applicableUs
Signature Care IbuprofenTablet, chewable100 mg/1OralSafeway2015-09-29Not applicableUs
Signature Care IbuprofenTablet, coated200 mg/1OralSafeway2015-09-14Not applicableUs
Signature Care IbuprofenTablet, film coated200 mg/1OralSafeway2015-08-12Not applicableUs
Signature Care Ibuprofen ChildrensSuspension100 mg/5mLOralSafeway2015-08-19Not applicableUs
Signature Care Infants IbuprofenSuspension / drops50 mg/1.25mLOralSafeway2015-09-28Not applicableUs
Simply Right IbuprofenTablet, film coated200 mg/1OralSam's West, Inc2011-12-18Not applicableUs
Smart Sense IbuprofenTablet, coated200 mg/1OralKmart Corporation2010-06-17Not applicableUs
Smart Sense IbuprofenTablet, chewable100 mg/1OralKmart Corporation2010-06-24Not applicableUs
Smart Sense IbuprofenSuspension100 mg/5mLOralKmart Corporation2010-05-20Not applicableUs
Smart Sense IbuprofenTablet, coated200 mg/1OralKmart Corporation2010-06-21Not applicableUs
Smart Sense IbuprofenSuspension100 mg/5mLOralKmart Corporation2010-05-20Not applicableUs
Smart Sense IbuprofenSuspension / drops50 mg/1.25mLOralKmart Corporation2010-05-14Not applicableUs
Smart Sense IbuprofenTablet, film coated200 mg/1OralKmart Corporation2010-06-04Not applicableUs
Smart Sense IbuprofenSuspension100 mg/5mLOralKmart Corporation2010-05-20Not applicableUs
Smart Sense Ibuprofen Gluten FreeTablet, film coated200 mg/1OralKmart Corporation2010-06-18Not applicableUs
Smart Sense Ibuprofen InfantsSuspension50 mg/1.25mLOralKmart Corporation2010-07-01Not applicableUs
Sound Body Childrens IbuprofenSuspension100 mg/5mLOralBig Lots Stores, Inc.2016-05-03Not applicableUs
Sound Body IbuprofenCapsule, liquid filled200 mg/1OralAllegiant Health2014-12-22Not applicableUs
Sound Body IbuprofenTablet, film coated200 mg/1OralBig Lots Stores, Inc.2015-04-21Not applicableUs
Sound Body IbuprofenTablet, film coated200 mg/1OralBig Lots Stores, Inc.2016-09-19Not applicableUs
Sunmark IbuprofenTablet, coated200 mg/1OralMc Kesson2003-06-24Not applicableUs
Sunmark IbuprofenSuspension / drops50 mg/1.25mLOralMc Kesson2004-04-29Not applicableUs
Sunmark IbuprofenTablet, film coated200 mg/1OralMc Kesson2003-06-24Not applicableUs
Sunmark IbuprofenSuspension100 mg/5mLOralMc Kesson2003-09-19Not applicableUs
Sunmark Ibuprofen ChildrensSuspension100 mg/5mLOralMc Kesson2003-09-06Not applicableUs
Sunmark Ibuprofen ChildrensSuspension100 mg/5mLOralMc Kesson2009-04-01Not applicableUs
Sunmark Ibuprofen ChildrensSuspension100 mg/5mLOralMc Kesson2003-09-19Not applicableUs
Sunmark Ibuprofen ChildrensSuspension100 mg/5mLOralMc Kesson2003-06-24Not applicableUs
Sunmark Ibuprofen IbTablet, chewable100 mg/1OralMc Kesson2004-07-10Not applicableUs
Sunmark Ibuprofen IbTablet, coated200 mg/1OralMc Kesson2006-03-20Not applicableUs
Sunmark Ibuprofen IbTablet, film coated200 mg/1OralMc Kesson2006-04-28Not applicableUs
Sunmark Ibuprofen InfantsSuspension50 mg/1.25mLOralMc Kesson2003-08-28Not applicableUs
Super Strength Motrin Ib Liquid GelsCapsule400 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2009-07-06Not applicableCanada
Super Strength Motrin Ib Liquid Gels CapsulesCapsule400 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2012-07-30Not applicableCanada
Super Strength Motrin Ib Menstrual PainTablet400 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Topcare Childrens IbuprofenSuspension100 mg/5mLOralTopco Associates2002-07-30Not applicableUs
Topcare Childrens IbuprofenSuspension100 mg/5mLOralTopco Associates2002-07-02Not applicableUs
Topcare IbuprofenTablet200 mg/1OralTopco Associates1988-02-15Not applicableUs
Topcare IbuprofenTablet, film coated256 mg/1OralTopco Associates2016-03-23Not applicableUs
Topcare IbuprofenTablet, film coated200 mg/1OralTopco Associates2006-04-28Not applicableUs
Topcare IbuprofenTablet, coated200 mg/1OralTopco Associates2006-04-10Not applicableUs
Topcare IbuprofenSuspension100 mg/5mLOralTopco Associates1998-12-31Not applicableUs
Topcare IbuprofenTablet, coated200 mg/1OralTopco Associates1988-11-15Not applicableUs
Topcare IbuprofenSuspension / drops50 mg/1.25mLOralTopco Associates2004-09-10Not applicableUs
Topcare IbuprofenTablet, film coated200 mg/1OralTopco Associates1993-04-22Not applicableUs
Topcare Ibuprofen ChildrensSuspension100 mg/5mLOralTopco Associates1995-02-03Not applicableUs
Topcare Ibuprofen Junior StrengthTablet, chewable100 mg/1OralTopco Associates2004-05-28Not applicableUs
Topcare Infants IbuprofenSuspension50 mg/1.25mLOralTopco Associates2002-01-22Not applicableUs
Up and Up Childrens IbuprofenSuspension100 mg/5mLOralTarget Corporation.2009-06-12Not applicableUs
Up and Up Childrens IbuprofenSuspension100 mg/5mLOralTarget Corporation.2009-06-12Not applicableUs
Up and Up Childrens IbuprofenSuspension100 mg/5mLOralTarget Corporation.2009-07-08Not applicableUs
Up and Up Childrens Ibuprofen Oral SuspensionSuspension100 mg/5mLOralTarget Corporation.2009-07-08Not applicableUs
Up and Up Dye Free Infants Concentrated IbuprofenSuspension / drops50 mg/1.25mLOralTarget Corporation.2009-07-08Not applicableUs
Up and Up IbuprofenTablet, film coated200 mg/1OralTarget Corporation.2009-05-28Not applicableUs
Up and Up IbuprofenTablet, coated200 mg/1OralTarget Corporation.2009-05-28Not applicableUs
Up and Up IbuprofenTablet, film coated200 mg/1OralTarget Corporation.2009-06-10Not applicableUs
Up and Up IbuprofenTablet, film coated200 mg/1OralTarget Corporation.2010-03-11Not applicableUs
Up and Up IbuprofenSuspension100 mg/5mLOralTarget Corporation.2009-07-10Not applicableUs
Up and Up Ibuprofen JuniorTablet, chewable100 mg/1OralTarget Corporation.2013-03-04Not applicableUs
Up and Up Ibuprofen SodiumTablet, film coated256 mg/1OralTarget Corporation.2017-03-02Not applicableUs
Up and Up Junior Strength IbuprofenTablet, chewable100 mg/1OralTarget Corporation.2010-06-22Not applicableUs
Valumeds IbuprofenTablet, film coated200 mg/1OralSpirit Pharmaceuticals, Llc2017-05-19Not applicableUs
Welby Health IbuprofenLiquid100 mg/5mLOralAldi, Inc2009-12-09Not applicableUs
Welby Health IbuprofenTablet200 mg/1OralAldi, Inc1993-06-01Not applicableUs
Welby IbuprofenTablet, film coated200 mg/1OralAldi, Inc2016-01-07Not applicableUs
Welby Infants IbuprofenSuspension / drops50 mg/1.25mLOralAldi, Inc2016-12-21Not applicableUs
Zee IbutabTablet200 mg/1OralZee Medical Inc2015-09-10Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
IbuprofenTablet200 mg/1OralCardinal Health2011-06-02Not applicableUs
International Brands
NameCompany
Act-3Healthcare Logistics
ActiprofenSterling Health
AdexDexxon
AdranNot Available
AktrenBayer
Alges-XAxapharm
AlgoflexChinoin
AlgofrenIntermed
AliviumBristol-Myers Squibb
ArtofenTeva
BetagesicAdcock Ingram Pharmaceuticals
BetaprofenBe-Tabs Pharmaceuticals
BlutonNot Available
BonifenKrka
BrufenAbbott
BuburoneTowa Yakuhin
BugesicNot Available
BuprovilNot Available
BuranaOrion
ButyleninNot Available
CalprofenMcNeil
Cap-ProfenPERRIGO
Children's ElixsurePfizer
Children's IbuprofenPfizer
DalsyAbbott
DismenolMerz
DiverinNot Available
DolgiridNot Available
DolgitDolorgiet
DolofortNot Available
DolorazNot Available
DolorminNot Available
DorivalNot Available
EbufacNot Available
EmuProfenNot Available
EpobronNot Available
EspidifenNot Available
EveNot Available
FemadonNot Available
FenbidNot Available
FenpaedNot Available
FinalflexNot Available
GalprofenNot Available
HaltranNot Available
Herron BlueNot Available
i-profen Not Available
IbalginNot Available
Ibu-AttritinNot Available
IBU-RatiopharmNot Available
Ibu-VivimedNot Available
IbuflamNot Available
IbugelNot Available
IbugesicNot Available
IbuHEXALNot Available
IbuleveNot Available
IbumNot Available
IbumaxNot Available
IbumetinNot Available
IbumidolNot Available
IbupainNot Available
IbuprocinNot Available
IbupromNot Available
IbuprosynNot Available
IbuproxNot Available
IbustarNot Available
IbutidNot Available
IbuxNot Available
IbuxinNot Available
InabrinNot Available
InovenNot Available
IprenNot Available
Junior Strength MotrinNot Available
KratalginNot Available
LamidonNot Available
LebrufenNot Available
LiptanNot Available
LotemNot Available
MedicolNot Available
MediprenNot Available
Midol IBNot Available
MotrinNot Available
MynosedinNot Available
MypaidNot Available
MyprodolNot Available
NarfenNot Available
Naron Ace Not Available
NeobrufenNot Available
NobfenNot Available
NobgenNot Available
NorvectanNot Available
NuprinNot Available
NureflexNot Available
NurofenNot Available
OrbifenNot Available
PanafenNot Available
PediaprofenNot Available
PerifarNot Available
ProfinNot Available
RanfenNot Available
RapidolNot Available
RatiodolorNot Available
RimafenNot Available
RoideninNot Available
RufenNot Available
SalvarinaNot Available
SeclodinNot Available
SolpaflexNot Available
Speedpain NANONot Available
SpidifenZambon
SusprenNot Available
TabalonNot Available
TefinNot Available
TrendarNot Available
UnafenNot Available
UpfenNot Available
UremNot Available
Brand mixtures
NameLabellerIngredients
10 Person AnsiGenuine First Aid
25 Person AnsiGenuine First Aid
50 Person AnsiGenuine First Aid
7 Select Ibuprofen PM7 Eleven
7-select Advil PMLil' Drug Store Products, Inc.
Advil Allergy and Congestion ReliefNavajo Manuracturing Company
Advil Allergy SinusPfizer
Advil Back PainPfizer Laboratories Div Pfizer Inc.
Advil Cold & FluPfizer Laboratories Div Pfizer Inc.
Advil Cold & Sinus Convenience PackPfizer Laboratories Div Pfizer Inc.
Advil Cold & Sinus Liqui-gelsPfizer Laboratories Div Pfizer Inc.
Advil Cold & Sinus PEPfizer Laboratories Div Pfizer Inc.
Advil Cold and SinusPfizer Laboratories Div Pfizer Inc.
Advil Cold and Sinus DaytimePfizer Laboratories Div Pfizer Inc.
Advil Cold and Sinus NighttimePfizer Laboratories Div Pfizer Inc.
Advil Cold and Sinus PlusPfizer Laboratories Div Pfizer Inc.
Advil Cold, Cough & Flu NighttimePfizer Laboratories Div Pfizer Inc.
Advil Congestion ReliefPfizer
Advil Day/night Convenience PackPfizer Laboratories Div Pfizer Inc.
Advil NighttimePfizer Laboratories Div Pfizer Inc.
Advil Pain & Head Cold NightPfizer Laboratories Div Pfizer Inc.
Advil PMLil' Drug Store Products, Inc.
Advil Sinus Congestion and PainPfizer
Advil Sinus Congestion and Pain ReliefNavajo Manuracturing Company
Analgesic and Muscle RelaxantPharmascience Inc
Analgesic and Muscle Relaxant CapletsTeva
Army and Airforce Exchange Ibuprofen PMArmy + Air Force Exchange Service
Auto 157Genuine First Aid
AxumTeva
Berkley and Jensen Ibuprofen PMBJWC
Care One Ibuprofen Cold and SinusAmerican Sales Company
Care One Ibuprofen PMAmerican Sales Company
Careone Ibuprofen PMAmerican Sales Company
Children's Advil ColdPfizer Laboratories Div Pfizer Inc.
Children's Advil Cold & Flu Multi-symptomPfizer Laboratories Div Pfizer Inc.
Children's Motrin ColdMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Childrens Advil ColdPfizer
CodofenPaladin Labs Inc
Cold & Sinus Relief CapsulesApotex Corporation
Cold + SinusVita Health Products Inc
Cold + Sinus CapletsVita Health Products Inc
Cold + Sinus DaytimeVita Health Products Inc
Cold + Sinus Daytime Cold + Sinus NighttimeVita Health Products Inc
Cold + Sinus NighttimeVita Health Products Inc
Cold + Sinus PlusVita Health Products Inc
Cold and Sinus Pain ReliefSafeway
Cold and Sinus PlusMarcan Pharmaceuticals Inc
Cold and Sinus ReliefCvs Health
Congestion ReliefMeijer Distribution
Dg Health Ibuprofen PMDolgencorp
Dimetapp Cold and Sinus CapletsWhitehall Robins Inc.
Dristan Sinus CapletsWhitehall Robins Inc.
DuexisHorizon Pharma, Inc.
Easy Care First Aid Kit - ComprehensiveTender Corporation
Equaline Congestion ReliefSupervalu
Equaline Ibuprofen Cold and SinusSupervalu
Equaline Ibuprofen PMSupervalu
Equate Ibuprofen Cold and SinusWalmart Stores
Equate Ibuprofen PMWalmart Stores
Genuine First Aid - Auto First AidGenuine First Aid
Genuine First Aid - Home First AidGenuine First Aid
Genuine First Aid Industrial First AidGenuine First Aid
Gfa First Aid Kit Essentials - 33 PiecesGenuine First Aid
Good Neighbor Pharmacy Childrens Ibuprofen ColdAmerisource Bergen
Good Neighbor Pharmacy Congestion ReliefAmerisource Bergen
Good Neighbor Pharmacy Ibuprofen Cold and SinusAmerisource Bergen
Good Neighbor Pharmacy Ibuprofen PMAmerisource Bergen
Good Sense Ibuprofen Cold and SinusL. Perrigo Company
Good Sense Ibuprofen PML. Perrigo Company
Harris Teeter Ibuprofen PMHarris Teeter
Health Mart Ibuprofen PMMc Kesson
Healthy Accents Congestion ReliefDza Brands,
Healthy Accents Ibuprofen PMDza Brands,
Hydrocodone BitartrateDirectrx
Hydrocodone Bitartrate and IbuprofenTeva
Ibu Profen Cold and SinusRite Aid
IbucodonePaladin Labs Inc
IbudonePoly Pharmaceuticals
Ibuprofen + Pseudoephedrine CapletsMarcan Pharmaceuticals Inc
Ibuprofen and Diphenhydramine CitrateDr Reddy's Laboratories
Ibuprofen and Diphenhydramine HClP & L Development Of New York Corporation
Ibuprofen and PseudoephedrineMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Ibuprofen and Pseudoephedrine HydrochlorideWalgreen
Ibuprofen Cold and SinusKroger
Ibuprofen Cold and Sinus A P JA P J Laboratories Limited
Ibuprofen Cold ChildrensMeijer Distribution
Ibuprofen Cold Relief ChildrensCvs Health
Ibuprofen Daytime, Ibuprofen NighttimeVita Health Products Inc
Ibuprofen NighttimeVita Health Products Inc
Ibuprofen PMWalgreen
Ibuprofen+methocarbamol CapletsMarcan Pharmaceuticals Inc
Leader Congestion ReliefCardinal Health
Leader Ibuprofen Cold and SinusCardinal Health
Leader Ibuprofen Cold ChildrensCardinal Health
Leader Ibuprofen PMCardinal Health
Motrin Cold & Sinus CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Motrin Cold & Sinus PainMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Motrin Platinum Muscle and BodyMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Motrin PMJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division
Mountain Series Weekender MedicalTender Corporation Dba Adventure Medical Kits
Muscle & Back Pain Relief With IbuprofenTeva
Muscle and Back Pain Platinum ReliefVita Health Products Inc
Muscle Relaxant and Analgesic CapletsInternational Pharmaceutical Generics Ltd
Nighttime Cold, Cough & FluApotex Corporation
Nighttime Pain ReliefApotex Corporation
Nighttime Pain RelieverMarcan Pharmaceuticals Inc
Oxycodone Hydrochloride and IbuprofenLake Erie Medical Dba Quality Care Produts Llc
Platinum Muscle and Back Pain ReliefVita Health Products Inc
PrasteraHealth Science Funding, Llc
Preferred Plus Congestion ReliefKinray
Ready America First Aid Outdoor- 107 PiecesGenuine First Aid
Ready America First Aid Pocket - 33 PiecesGenuine First Aid
Regular Strength Analgesic & Muscle Relaxant CapletsTeva
ReprexainStat Rx USA
Robax PlatinumPfizer Laboratories Div Pfizer Inc.
Rugby Congestion ReliefRugby
Rx Act Ibuprofen PMH.E.B.
Shoprite Ibuprofen PMWakfern Food Corporation
Signature Care Ibuprofen PMSafeway
Smart Sense Ibuprofen PMKmart Corporation
Sudafed Sinus AdvanceMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Summit UltraPendopharm Division Of De Pharmascience Inc
Sunmark Ibuprofen Cold and SinusMc Kesson
Sunmark Ibuprofen PMMc Kesson
Theraprofen-60Physician Therapeutics Llc
Theraprofen-800Physician Therapeutics Llc
Theraprofen-90Physician Therapeutics Llc
Topcare Congestion ReliefTopco Associates
Topcare Ibuprofen Cold and SinusTopco Associates
Topcare Ibuprofen PMTopco Associates
Up and Up Cold and SinusTarget Corporation.
Up and Up Ibuprofen PMTarget Corporation.
Vicks Dayquil Sinus Pr.and Pain ReL.W.ibupr.Procter And Gamble
VicoprofenAbbvie
Wal Profen Cold and SinusWalgreen
Xylon 10Sircle Laboratories, Llc
Categories
UNIIWK2XYI10QM
CAS number15687-27-1
WeightAverage: 206.2808
Monoisotopic: 206.13067982
Chemical FormulaC13H18O2
InChI KeyHEFNNWSXXWATRW-UHFFFAOYSA-N
InChI
InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
IUPAC Name
2-[4-(2-methylpropyl)phenyl]propanoic acid
SMILES
CC(C)CC1=CC=C(C=C1)C(C)C(O)=O
Pharmacology
Indication

For symptomatic treatment of rheumatoid arthritis, juvenile rheumatoid arthritis and osteoarthritis. May be used to treat mild to moderate pain and for the management of dysmenorrhea. May be used to reduce fever. Has been used with some success for treating ankylosing spondylitis, gout and psoriatic arthritis. May reduce pain, fever and inflammation of pericarditis. May be used IV with opiates to relieve moderate to severe pain. Ibuprofen lysine may be used IV to treat patent ductus arteriosus (PDA) in premature neonates.

Structured Indications
Pharmacodynamics

Ibuprofen is a nonsteroidal anti-inflammatory agent (NSAIA) or nonsteroidal anti-inflammatory drug (NSAID), with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, which are thought to act through inhibition of prostaglandin synthesis.

Mechanism of action

The exact mechanism of action of ibuprofen is unknown. Ibuprofen is a non-selective inhibitor of cyclooxygenase, an enzyme invovled in prostaglandin synthesis via the arachidonic acid pathway. Its pharmacological effects are believed to be due to inhibition cylooxygenase-2 (COX-2) which decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever and swelling. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Inhibition of COX-1 is thought to cause some of the side effects of ibuprofen including GI ulceration. Ibuprofen is administered as a racemic mixture. The R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo. The S-enantiomer is believed to be the more pharmacologically active enantiomer.

TargetKindPharmacological actionActionsOrganismUniProt ID
Prostaglandin G/H synthase 2Proteinyes
inhibitor
HumanP35354 details
Prostaglandin G/H synthase 1ProteinyesNot AvailableHumanP23219 details
Apoptosis regulator Bcl-2Proteinunknown
modulator
HumanP10415 details
ThrombomodulinProteinunknown
modulator
HumanP07204 details
Tissue-type plasminogen activatorProteinunknown
negative modulator
HumanP00750 details
Fatty acid-binding protein, intestinalProteinunknown
binder
HumanP12104 details
Peroxisome proliferator-activated receptor gammaProteinunknown
activator
HumanP37231 details
Cystic fibrosis transmembrane conductance regulatorProteinunknown
inhibitor
HumanP13569 details
Related Articles
Absorption

~ 80% absorbed from GI tract

Time to reach peak plasma concentration = 47 minutes (suspension), 62 minutes (chewable tablets), 120 minutes (conventional tablets)

Volume of distributionNot Available
Protein binding

90-99% to whole human plasma and site II of purified albumin, binding appears to be saturable and becomes non-linear at concentrations exceeding 20 mcg/ml.

Metabolism

R-enanatiomer undergoes extensive enantiomeric conversion (53-65%) to the more active S-enantiomer in vivo. Metablized by oxidation to 2 inactive metabolites: (+)-2[4´-(2-hydroxy-2-methylpropyl)phenyl]propionic acid and (+)-2-[4´-(2-carboxypropyl)phenyl]propionic acid. Very small amounts of 1-hydroxyibuprofen and 3-hydroxyibuprofen have been recovered from urine. Cytochrome P450 2C9 is the major catalyst in the formation of oxidative metabolites. Oxidative metabolites may be conjugated to glucuronide prior to excretion.

SubstrateEnzymesProduct
Ibuprofen
Ibuprofen glucuronideDetails
Ibuprofen
2-HydroxyibuprofenDetails
Ibuprofen
3-HydroxyibuprofenDetails
Ibuprofen
Not Available
1-hydroxyibuprofenDetails
3-Hydroxyibuprofen
Carboxy-ibuprofenDetails
Route of elimination

Ibuprofen is rapidly metabolized and eliminated in the urine.

Half life

2-4 hours

ClearanceNot Available
Toxicity

Side effects: May cause peripheral edema and fluid retention. Use caution in patients with congestive heart failure or severe uncontrolled hypertension. May cause dyspepsia, heartburn, nausea, vomiting, anorexia, diarrhea, constipation, stomatitis, flatulence, bloating, epigastric pain, and abdominal pain. Peptic ulcer and GI bleeding have been reported. May also cause dizziness, headache and nervousness. Acute renal failure accompanied by acute tubular necrosis has been reported.

Most common symptoms of overdose are abdominal pain, nausea, vomiting, lethargy, vertigo, drowsiness (somnolence), dizziness and insomnia. Other symptoms of overdose include headache, loss of consciousness, tinnitus, CNS depression, convulsions and seizures. May rarely cause metabolic acidosis, abnormal hepatic function, hyperkalemia, renal failure, dyspnea, respiratory depression, coma, acute renal failure, and apnea (primarily in very young pediatric patients).

LD50=1255mg/kg(orally in mice)

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Ibuprofen Action PathwayDrug actionSMP00086
Ibuprofen Metabolism PathwayDrug metabolismSMP00590
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with 16-Bromoepiandrosterone.Investigational
19-norandrostenedioneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with 19-norandrostenedione.Experimental, Illicit
5-androstenedioneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with 5-androstenedione.Experimental, Illicit
AbciximabIbuprofen may increase the anticoagulant activities of Abciximab.Approved
AbirateroneThe serum concentration of Ibuprofen can be increased when it is combined with Abiraterone.Approved
AcebutololIbuprofen may decrease the antihypertensive activities of Acebutolol.Approved
AceclofenacThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Aceclofenac.Approved
AcenocoumarolIbuprofen may increase the anticoagulant activities of Acenocoumarol.Approved
AcetaminophenThe serum concentration of Ibuprofen can be increased when it is combined with Acetaminophen.Approved
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Ibuprofen.Approved, Vet Approved
AclarubicinIbuprofen may decrease the excretion rate of Aclarubicin which could result in a higher serum level.Investigational
AdapaleneThe risk or severity of adverse effects can be increased when Adapalene is combined with Ibuprofen.Approved
AfatinibThe serum concentration of Ibuprofen can be increased when it is combined with Afatinib.Approved
AlbendazoleThe serum concentration of Ibuprofen can be increased when it is combined with Albendazole.Approved, Vet Approved
AlclometasoneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Alclometasone.Approved
AldosteroneThe serum concentration of Ibuprofen can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Ibuprofen can be increased when it is combined with Alectinib.Approved
Alendronic acidThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Alendronic acid.Approved
AlfentanilThe serum concentration of Ibuprofen can be increased when it is combined with Alfentanil.Approved, Illicit
AliskirenIbuprofen may decrease the antihypertensive activities of Aliskiren.Approved, Investigational
AlprenololIbuprofen may decrease the antihypertensive activities of Alprenolol.Approved, Withdrawn
AlprostadilThe therapeutic efficacy of Alprostadil can be decreased when used in combination with Ibuprofen.Approved, Investigational
AmantadineThe serum concentration of Ibuprofen can be increased when it is combined with Amantadine.Approved
AmcinonideThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Amcinonide.Approved
AmikacinIbuprofen may decrease the excretion rate of Amikacin which could result in a higher serum level.Approved, Vet Approved
AmilorideIbuprofen may decrease the antihypertensive activities of Amiloride.Approved
Aminohippuric acidThe serum concentration of Ibuprofen can be increased when it is combined with Aminohippuric acid.Approved
AmiodaroneThe metabolism of Ibuprofen can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Ibuprofen can be increased when it is combined with Amitriptyline.Approved
AmlodipineThe serum concentration of Ibuprofen can be increased when it is combined with Amlodipine.Approved
AmprenavirThe serum concentration of Ibuprofen can be decreased when it is combined with Amprenavir.Approved
AmrubicinIbuprofen may decrease the excretion rate of Amrubicin which could result in a higher serum level.Approved, Investigational
AmsacrineThe serum concentration of Ibuprofen can be increased when it is combined with Amsacrine.Approved
AncrodIbuprofen may increase the anticoagulant activities of Ancrod.Investigational
AndrographolideThe risk or severity of adverse effects can be increased when Ibuprofen is combined with HMPL-004.Investigational
AndrostenedioneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with 4-Androstenedione.Experimental, Illicit
AntipyrineThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Antipyrine.Approved
Antithrombin III humanIbuprofen may increase the anticoagulant activities of Antithrombin III human.Approved
ApixabanIbuprofen may increase the anticoagulant activities of Apixaban.Approved
ApramycinIbuprofen may decrease the excretion rate of Apramycin which could result in a higher serum level.Experimental, Vet Approved
ApremilastThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Apremilast.Approved, Investigational
AprepitantThe metabolism of Ibuprofen can be increased when combined with Aprepitant.Approved, Investigational
ArbekacinIbuprofen may decrease the excretion rate of Arbekacin which could result in a higher serum level.Approved
ArdeparinIbuprofen may increase the anticoagulant activities of Ardeparin.Approved, Withdrawn
ArgatrobanIbuprofen may increase the anticoagulant activities of Argatroban.Approved, Investigational
ArmodafinilThe metabolism of Ibuprofen can be decreased when combined with Armodafinil.Approved, Investigational
ArotinololIbuprofen may decrease the antihypertensive activities of Arotinolol.Approved
AstemizoleThe serum concentration of Ibuprofen can be increased when it is combined with Astemizole.Approved, Withdrawn
AtazanavirThe serum concentration of Ibuprofen can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Ibuprofen can be increased when it is combined with Atenolol.Approved
AtorvastatinThe serum concentration of Ibuprofen can be increased when it is combined with Atorvastatin.Approved
AzapropazoneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Azapropazone.Withdrawn
AzelastineThe serum concentration of Ibuprofen can be increased when it is combined with Azelastine.Approved
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Azilsartan medoxomil is combined with Ibuprofen.Approved
AzithromycinThe serum concentration of Ibuprofen can be increased when it is combined with Azithromycin.Approved
BalsalazideIbuprofen may increase the nephrotoxic activities of Balsalazide.Approved, Investigational
BecaplerminIbuprofen may increase the anticoagulant activities of Becaplermin.Approved, Investigational
Beclomethasone dipropionateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Beclomethasone dipropionate.Approved, Investigational
BefunololIbuprofen may decrease the antihypertensive activities of Befunolol.Experimental
BenazeprilThe risk or severity of adverse effects can be increased when Benazepril is combined with Ibuprofen.Approved, Investigational
BendroflumethiazideThe therapeutic efficacy of Bendroflumethiazide can be decreased when used in combination with Ibuprofen.Approved
BenoxaprofenThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Benoxaprofen.Withdrawn
BenzocaineThe serum concentration of Ibuprofen can be increased when it is combined with Benzocaine.Approved
BepridilThe serum concentration of Ibuprofen can be increased when it is combined with Bepridil.Approved, Withdrawn
BeraprostThe therapeutic efficacy of Beraprost can be decreased when used in combination with Ibuprofen.Investigational
BetamethasoneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Betamethasone.Approved, Vet Approved
BetaxololIbuprofen may decrease the antihypertensive activities of Betaxolol.Approved
Betulinic AcidThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Betulinic Acid.Investigational
BevantololIbuprofen may decrease the antihypertensive activities of Bevantolol.Approved
BimatoprostThe therapeutic efficacy of Bimatoprost can be decreased when used in combination with Ibuprofen.Approved, Investigational
BiperidenThe serum concentration of Ibuprofen can be increased when it is combined with Biperiden.Approved
BisoprololIbuprofen may decrease the antihypertensive activities of Bisoprolol.Approved
BivalirudinIbuprofen may increase the anticoagulant activities of Bivalirudin.Approved, Investigational
BopindololIbuprofen may decrease the antihypertensive activities of Bopindolol.Approved
BortezomibThe metabolism of Ibuprofen can be decreased when combined with Bortezomib.Approved, Investigational
BosutinibThe serum concentration of Ibuprofen can be increased when it is combined with Bosutinib.Approved
BromfenacThe risk or severity of adverse effects can be increased when Bromfenac is combined with Ibuprofen.Approved
BromocriptineThe serum concentration of Ibuprofen can be increased when it is combined with Bromocriptine.Approved, Investigational
BudesonideThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Budesonide.Approved
BufuralolIbuprofen may decrease the antihypertensive activities of Bufuralol.Experimental, Investigational
BumetanideIbuprofen may decrease the diuretic activities of Bumetanide.Approved
BupranololIbuprofen may decrease the antihypertensive activities of Bupranolol.Approved
BuprenorphineThe serum concentration of Ibuprofen can be increased when it is combined with Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe serum concentration of Ibuprofen can be increased when it is combined with Buspirone.Approved, Investigational
CabazitaxelThe serum concentration of Ibuprofen can be increased when it is combined with Cabazitaxel.Approved
CaffeineThe serum concentration of Ibuprofen can be increased when it is combined with Caffeine.Approved
CanagliflozinThe serum concentration of Ibuprofen can be increased when it is combined with Canagliflozin.Approved
CandesartanThe serum concentration of Ibuprofen can be increased when it is combined with Candesartan.Approved
CandoxatrilThe risk or severity of adverse effects can be increased when Candoxatril is combined with Ibuprofen.Experimental
CapecitabineThe metabolism of Ibuprofen can be decreased when combined with Capecitabine.Approved, Investigational
CaptoprilThe serum concentration of Ibuprofen can be increased when it is combined with Captopril.Approved
CarbamazepineThe metabolism of Ibuprofen can be increased when combined with Carbamazepine.Approved, Investigational
Carboprost TromethamineThe therapeutic efficacy of Carboprost Tromethamine can be decreased when used in combination with Ibuprofen.Approved
CarprofenThe risk or severity of adverse effects can be increased when Carprofen is combined with Ibuprofen.Approved, Vet Approved, Withdrawn
CarteololIbuprofen may decrease the antihypertensive activities of Carteolol.Approved
CarvedilolThe serum concentration of Ibuprofen can be increased when it is combined with Carvedilol.Approved, Investigational
CaspofunginThe serum concentration of Ibuprofen can be increased when it is combined with Caspofungin.Approved
CastanospermineThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Castanospermine.Experimental
CelecoxibThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Celecoxib.Approved, Investigational
CeliprololIbuprofen may decrease the antihypertensive activities of Celiprolol.Approved, Investigational
CeritinibThe serum concentration of Ibuprofen can be increased when it is combined with Ceritinib.Approved
CertoparinIbuprofen may increase the anticoagulant activities of Certoparin.Approved
ChloramphenicolThe metabolism of Ibuprofen can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChloroquineThe serum concentration of Ibuprofen can be increased when it is combined with Chloroquine.Approved, Vet Approved
ChlorothiazideThe therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Ibuprofen.Approved, Vet Approved
ChlorpromazineThe serum concentration of Ibuprofen can be increased when it is combined with Chlorpromazine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Ibuprofen can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Ibuprofen can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
ChlorthalidoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Ibuprofen.Approved
CholecalciferolThe metabolism of Ibuprofen can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CholesterolThe serum concentration of Ibuprofen can be increased when it is combined with Cholesterol.Experimental
CholestyramineCholestyramine can cause a decrease in the absorption of Ibuprofen resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Cholic AcidThe serum concentration of Ibuprofen can be decreased when it is combined with Cholic Acid.Approved
Choline magnesium trisalicylateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Trisalicylate-choline.Approved
CiclesonideThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Ciclesonide.Approved, Investigational
CilazaprilThe serum concentration of Ibuprofen can be increased when it is combined with Cilazapril.Approved
CimetidineThe serum concentration of Ibuprofen can be decreased when it is combined with Cimetidine.Approved
CinoxacinIbuprofen may increase the neuroexcitatory activities of Cinoxacin.Approved, Withdrawn
CiprofloxacinIbuprofen may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
CitalopramThe serum concentration of Ibuprofen can be increased when it is combined with Citalopram.Approved
Citric AcidIbuprofen may increase the anticoagulant activities of Citric Acid.Nutraceutical, Vet Approved
ClarithromycinThe serum concentration of Ibuprofen can be increased when it is combined with Clarithromycin.Approved
Clobetasol propionateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Clobetasol propionate.Approved
ClocortoloneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Clocortolone.Approved
Clodronic AcidThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Clodronate.Approved, Investigational, Vet Approved
ClofazimineThe serum concentration of Ibuprofen can be increased when it is combined with Clofazimine.Approved, Investigational
ClomipramineThe serum concentration of Ibuprofen can be increased when it is combined with Clomipramine.Approved, Vet Approved
ClonixinThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Clonixin.Approved
ClopidogrelThe metabolism of Ibuprofen can be decreased when combined with Clopidogrel.Approved, Nutraceutical
ClotrimazoleThe serum concentration of Ibuprofen can be decreased when it is combined with Clotrimazole.Approved, Vet Approved
CobicistatThe serum concentration of Ibuprofen can be increased when it is combined with Cobicistat.Approved
ColchicineThe serum concentration of Ibuprofen can be increased when it is combined with Colchicine.Approved
ColesevelamColesevelam can cause a decrease in the absorption of Ibuprofen resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Ibuprofen resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColforsinThe serum concentration of Ibuprofen can be increased when it is combined with Colforsin.Experimental
Cortisone acetateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Cortisone acetate.Approved
CrizotinibThe serum concentration of Ibuprofen can be increased when it is combined with Crizotinib.Approved
CyclophosphamideThe serum concentration of Ibuprofen can be increased when it is combined with Cyclophosphamide.Approved, Investigational
CyclosporineIbuprofen may increase the nephrotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
CyclosporineThe serum concentration of Ibuprofen can be decreased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
Dabigatran etexilateIbuprofen may increase the anticoagulant activities of Dabigatran etexilate.Approved
DabrafenibThe serum concentration of Ibuprofen can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Ibuprofen can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Ibuprofen can be increased when it is combined with Dactinomycin.Approved
DalteparinIbuprofen may increase the anticoagulant activities of Dalteparin.Approved
DasatinibThe serum concentration of Ibuprofen can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinIbuprofen may decrease the excretion rate of Daunorubicin which could result in a higher serum level.Approved
DeferasiroxThe serum concentration of Ibuprofen can be increased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Ibuprofen can be decreased when combined with Delavirdine.Approved
DesipramineThe serum concentration of Ibuprofen can be increased when it is combined with Desipramine.Approved
DesirudinIbuprofen may increase the anticoagulant activities of Desirudin.Approved
DesloratadineThe serum concentration of Ibuprofen can be increased when it is combined with Desloratadine.Approved, Investigational
DesmopressinThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Desmopressin.Approved
DesoximetasoneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Desoximetasone.Approved
Desoxycorticosterone PivalateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Desoxycorticosterone Pivalate.Experimental, Vet Approved
DexamethasoneThe serum concentration of Ibuprofen can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Ibuprofen.Approved
DextranIbuprofen may increase the anticoagulant activities of Dextran.Approved, Vet Approved
Dextran 40Ibuprofen may increase the anticoagulant activities of Dextran 40.Approved
DextromethorphanThe serum concentration of Ibuprofen can be increased when it is combined with Dextromethorphan.Approved
DiclofenacThe risk or severity of adverse effects can be increased when Diclofenac is combined with Ibuprofen.Approved, Vet Approved
DiclofenacThe serum concentration of Ibuprofen can be increased when it is combined with Diclofenac.Approved, Vet Approved
DicoumarolIbuprofen may increase the anticoagulant activities of Dicoumarol.Approved
DiflorasoneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Diflorasone.Approved
DiflunisalThe risk or severity of adverse effects can be increased when Diflunisal is combined with Ibuprofen.Approved
DifluocortoloneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Difluocortolone.Approved
DifluprednateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Difluprednate.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Ibuprofen.Approved
DihydroergotamineThe serum concentration of Ibuprofen can be increased when it is combined with Dihydroergotamine.Approved
DiltiazemThe serum concentration of Ibuprofen can be increased when it is combined with Diltiazem.Approved
Dinoprost TromethamineThe therapeutic efficacy of Dinoprost Tromethamine can be decreased when used in combination with Ibuprofen.Approved, Vet Approved
DinoprostoneThe therapeutic efficacy of Dinoprostone can be decreased when used in combination with Ibuprofen.Approved
DipyridamoleThe serum concentration of Ibuprofen can be increased when it is combined with Dipyridamole.Approved
DoxazosinThe serum concentration of Ibuprofen can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Ibuprofen can be increased when it is combined with Doxepin.Approved
DoxorubicinIbuprofen may decrease the excretion rate of Doxorubicin which could result in a higher serum level.Approved, Investigational
DronabinolThe serum concentration of Ibuprofen can be increased when it is combined with Dronabinol.Approved, Illicit
DronedaroneThe serum concentration of Ibuprofen can be increased when it is combined with Dronedarone.Approved
DrospirenoneIbuprofen may increase the hyperkalemic activities of Drospirenone.Approved
DroxicamThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Droxicam.Approved
Edetic AcidIbuprofen may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanIbuprofen may increase the anticoagulant activities of Edoxaban.Approved
EfavirenzThe metabolism of Ibuprofen can be decreased when combined with Efavirenz.Approved, Investigational
ElbasvirThe serum concentration of Ibuprofen can be increased when it is combined with Elbasvir.Approved
EnalaprilThe serum concentration of Ibuprofen can be increased when it is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe risk or severity of adverse effects can be increased when Enalaprilat is combined with Ibuprofen.Approved
EnoxacinIbuprofen may increase the neuroexcitatory activities of Enoxacin.Approved
EnoxaparinIbuprofen may increase the anticoagulant activities of Enoxaparin.Approved
EnzalutamideThe serum concentration of Ibuprofen can be increased when it is combined with Enzalutamide.Approved
EpirizoleThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Epirizole.Approved
EpirubicinIbuprofen may decrease the excretion rate of Epirubicin which could result in a higher serum level.Approved
EplerenoneIbuprofen may decrease the antihypertensive activities of Eplerenone.Approved
EpoprostenolThe therapeutic efficacy of Epoprostenol can be decreased when used in combination with Ibuprofen.Approved
EprosartanThe risk or severity of adverse effects can be increased when Eprosartan is combined with Ibuprofen.Approved
EquileninThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Equilenin.Experimental
EquilinThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Equilin.Approved
ErgonovineThe serum concentration of Ibuprofen can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Ibuprofen can be increased when it is combined with Ergotamine.Approved
ErythromycinThe serum concentration of Ibuprofen can be decreased when it is combined with Erythromycin.Approved, Vet Approved
Eslicarbazepine acetateThe metabolism of Ibuprofen can be decreased when combined with Eslicarbazepine acetate.Approved
EsmololIbuprofen may decrease the antihypertensive activities of Esmolol.Approved
EsomeprazoleThe metabolism of Ibuprofen can be decreased when combined with Esomeprazole.Approved, Investigational
EstramustineThe serum concentration of Ibuprofen can be increased when it is combined with Estramustine.Approved
EstriolThe serum concentration of Ibuprofen can be decreased when it is combined with Estriol.Approved, Vet Approved
EstroneThe serum concentration of Ibuprofen can be decreased when it is combined with Estrone.Approved
Estrone sulfateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Estrone sulfate.Approved
Etacrynic acidIbuprofen may decrease the diuretic activities of Etacrynic acid.Approved
EtanerceptThe risk or severity of adverse effects can be increased when Etanercept is combined with Ibuprofen.Approved, Investigational
Ethyl biscoumacetateIbuprofen may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
Etidronic acidThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Etidronic acid.Approved
EtodolacThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Etodolac.Approved, Investigational, Vet Approved
EtofenamateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Etofenamate.Approved
EtoposideThe serum concentration of Ibuprofen can be increased when it is combined with Etoposide.Approved
EtoricoxibThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Etoricoxib.Approved, Investigational
EtravirineThe serum concentration of Ibuprofen can be increased when it is combined with Etravirine.Approved
FelodipineThe serum concentration of Ibuprofen can be increased when it is combined with Felodipine.Approved, Investigational
FenbufenThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Fenbufen.Approved
FenoprofenThe risk or severity of adverse effects can be increased when Fenoprofen is combined with Ibuprofen.Approved
FentanylThe serum concentration of Ibuprofen can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe serum concentration of Ibuprofen can be increased when it is combined with Fexofenadine.Approved
FidaxomicinThe serum concentration of Ibuprofen can be increased when it is combined with Fidaxomicin.Approved
FleroxacinIbuprofen may increase the neuroexcitatory activities of Fleroxacin.Approved
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Ibuprofen.Approved, Withdrawn
FloxuridineThe metabolism of Ibuprofen can be decreased when combined with Floxuridine.Approved
FluconazoleThe metabolism of Ibuprofen can be decreased when combined with Fluconazole.Approved
FludrocortisoneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Fludrocortisone.Approved
FlumequineIbuprofen may increase the neuroexcitatory activities of Flumequine.Withdrawn
FlumethasoneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Flumethasone.Approved, Vet Approved
FlunisolideThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Flunisolide.Approved, Investigational
Fluocinolone AcetonideThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Fluocinolone Acetonide.Approved, Investigational, Vet Approved
FluocinonideThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Fluocinonide.Approved, Investigational
FluocortoloneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Fluocortolone.Approved, Withdrawn
FluorometholoneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Fluorometholone.Approved
FluorouracilThe metabolism of Ibuprofen can be decreased when combined with Fluorouracil.Approved
FluoxetineThe serum concentration of Ibuprofen can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe serum concentration of Ibuprofen can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Ibuprofen can be increased when it is combined with Fluphenazine.Approved
FluprednideneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Fluprednidene.Approved, Withdrawn
FlurandrenolideThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Flurandrenolide.Approved
FlurazepamThe serum concentration of Ibuprofen can be increased when it is combined with Flurazepam.Approved, Illicit
FlurbiprofenThe risk or severity of adverse effects can be increased when Flurbiprofen is combined with Ibuprofen.Approved, Investigational
Fluticasone furoateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Fluticasone furoate.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Fluticasone Propionate.Approved
FluvastatinThe metabolism of Ibuprofen can be decreased when combined with Fluvastatin.Approved
FluvoxamineThe metabolism of Ibuprofen can be decreased when combined with Fluvoxamine.Approved, Investigational
Folic AcidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Ibuprofen.Approved, Nutraceutical, Vet Approved
Fondaparinux sodiumIbuprofen may increase the anticoagulant activities of Fondaparinux sodium.Approved, Investigational
ForasartanThe risk or severity of adverse effects can be increased when Forasartan is combined with Ibuprofen.Experimental
FormestaneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Formestane.Approved, Investigational, Withdrawn
FosinoprilThe risk or severity of adverse effects can be increased when Fosinopril is combined with Ibuprofen.Approved
FosphenytoinThe metabolism of Ibuprofen can be increased when combined with Fosphenytoin.Approved
FramycetinIbuprofen may decrease the excretion rate of Framycetin which could result in a higher serum level.Approved
FurosemideIbuprofen may decrease the diuretic activities of Furosemide.Approved, Vet Approved
GabexateIbuprofen may increase the anticoagulant activities of Gabexate.Investigational
GatifloxacinIbuprofen may increase the neuroexcitatory activities of Gatifloxacin.Approved, Investigational
GefitinibThe serum concentration of Ibuprofen can be increased when it is combined with Gefitinib.Approved, Investigational
GemeprostThe therapeutic efficacy of Gemeprost can be decreased when used in combination with Ibuprofen.Approved, Withdrawn
GemfibrozilThe metabolism of Ibuprofen can be decreased when combined with Gemfibrozil.Approved
GemifloxacinIbuprofen may increase the neuroexcitatory activities of Gemifloxacin.Approved, Investigational
GeneticinIbuprofen may decrease the excretion rate of Geneticin which could result in a higher serum level.Experimental
GenisteinThe serum concentration of Ibuprofen can be increased when it is combined with Genistein.Investigational
GentamicinIbuprofen may decrease the excretion rate of Gentamicin which could result in a higher serum level.Approved, Vet Approved
GENTAMICIN C1AIbuprofen may decrease the excretion rate of GENTAMICIN C1A which could result in a higher serum level.Experimental
GlyburideThe serum concentration of Ibuprofen can be increased when it is combined with Glyburide.Approved
Gramicidin DThe serum concentration of Ibuprofen can be increased when it is combined with Gramicidin D.Approved
GrepafloxacinIbuprofen may increase the neuroexcitatory activities of Grepafloxacin.Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Haloperidol.Approved
HE3286The risk or severity of adverse effects can be increased when Ibuprofen is combined with HE3286.Investigational
HeparinIbuprofen may increase the anticoagulant activities of Heparin.Approved, Investigational
HydralazineIbuprofen may decrease the antihypertensive activities of Hydralazine.Approved
HydrochlorothiazideThe therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Ibuprofen.Approved, Vet Approved
HydrocortisoneThe serum concentration of Ibuprofen can be increased when it is combined with Hydrocortisone.Approved, Vet Approved
HydroflumethiazideThe therapeutic efficacy of Hydroflumethiazide can be decreased when used in combination with Ibuprofen.Approved
IbandronateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Ibandronate.Approved, Investigational
IbuproxamThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Ibuproxam.Withdrawn
IcatibantThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Icatibant.Approved
IdarubicinIbuprofen may decrease the excretion rate of Idarubicin which could result in a higher serum level.Approved
IdelalisibThe serum concentration of Ibuprofen can be increased when it is combined with Idelalisib.Approved
IloprostThe therapeutic efficacy of Iloprost can be decreased when used in combination with Ibuprofen.Approved, Investigational
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Ibuprofen.Approved
ImipramineThe serum concentration of Ibuprofen can be increased when it is combined with Imipramine.Approved
IndapamideThe therapeutic efficacy of Indapamide can be decreased when used in combination with Ibuprofen.Approved
IndenololIbuprofen may decrease the antihypertensive activities of Indenolol.Withdrawn
IndinavirThe serum concentration of Ibuprofen can be decreased when it is combined with Indinavir.Approved
IndomethacinThe serum concentration of Ibuprofen can be increased when it is combined with Indomethacin.Approved, Investigational
IndoprofenThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Indoprofen.Withdrawn
IrbesartanThe metabolism of Ibuprofen can be decreased when combined with Irbesartan.Approved, Investigational
IsavuconazoniumThe serum concentration of Ibuprofen can be increased when it is combined with Isavuconazonium.Approved, Investigational
IsoniazidThe metabolism of Ibuprofen can be decreased when combined with Isoniazid.Approved
IsoxicamThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Isoxicam.Withdrawn
ItraconazoleThe serum concentration of Ibuprofen can be increased when it is combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Ibuprofen can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ibuprofen can be increased when it is combined with Ivermectin.Approved, Vet Approved
KanamycinIbuprofen may decrease the excretion rate of Kanamycin which could result in a higher serum level.Approved, Vet Approved
KebuzoneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Kebuzone.Experimental
KetamineThe serum concentration of Ibuprofen can be increased when it is combined with Ketamine.Approved, Vet Approved
KetoconazoleThe serum concentration of Ibuprofen can be increased when it is combined with Ketoconazole.Approved, Investigational
KetoprofenThe risk or severity of adverse effects can be increased when Ketoprofen is combined with Ibuprofen.Approved, Vet Approved
KetorolacThe risk or severity of adverse effects can be increased when Ketorolac is combined with Ibuprofen.Approved
LabetalolIbuprofen may decrease the antihypertensive activities of Labetalol.Approved
LansoprazoleThe serum concentration of Ibuprofen can be increased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Ibuprofen can be increased when it is combined with Lapatinib.Approved, Investigational
LatanoprostThe therapeutic efficacy of Latanoprost can be decreased when used in combination with Ibuprofen.Approved, Investigational
LeflunomideThe metabolism of Ibuprofen can be decreased when combined with Leflunomide.Approved, Investigational
LepirudinIbuprofen may increase the anticoagulant activities of Lepirudin.Approved
LevobunololIbuprofen may decrease the antihypertensive activities of Levobunolol.Approved
LevofloxacinIbuprofen may increase the neuroexcitatory activities of Levofloxacin.Approved, Investigational
LevothyroxineThe serum concentration of Ibuprofen can be decreased when it is combined with Levothyroxine.Approved
LidocaineThe serum concentration of Ibuprofen can be increased when it is combined with Lidocaine.Approved, Vet Approved
LimaprostThe therapeutic efficacy of Limaprost can be decreased when used in combination with Ibuprofen.Approved
LiothyronineThe serum concentration of Ibuprofen can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Ibuprofen can be decreased when it is combined with Liotrix.Approved
LisinoprilThe serum concentration of Ibuprofen can be increased when it is combined with Lisinopril.Approved, Investigational
LithiumThe serum concentration of Lithium can be increased when it is combined with Ibuprofen.Approved
LomefloxacinIbuprofen may increase the neuroexcitatory activities of Lomefloxacin.Approved
LomitapideThe serum concentration of Ibuprofen can be increased when it is combined with Lomitapide.Approved
LoperamideThe serum concentration of Ibuprofen can be increased when it is combined with Loperamide.Approved
LopinavirThe metabolism of Ibuprofen can be increased when combined with Lopinavir.Approved
LoratadineThe serum concentration of Ibuprofen can be increased when it is combined with Loratadine.Approved
LornoxicamThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Lornoxicam.Approved
LosartanThe serum concentration of Ibuprofen can be increased when it is combined with Losartan.Approved
LovastatinThe serum concentration of Ibuprofen can be increased when it is combined with Lovastatin.Approved, Investigational
LoxoprofenThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Loxoprofen.Approved
LubiprostoneThe therapeutic efficacy of Lubiprostone can be decreased when used in combination with Ibuprofen.Approved, Investigational
LuliconazoleThe serum concentration of Ibuprofen can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Ibuprofen can be increased when it is combined with Lumacaftor.Approved
LumiracoxibThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Lumiracoxib.Approved, Investigational
Magnesium salicylateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Magnesium salicylate.Approved
MaprotilineThe serum concentration of Ibuprofen can be increased when it is combined with Maprotiline.Approved
MasoprocolThe risk or severity of adverse effects can be increased when Masoprocol is combined with Ibuprofen.Approved
ME-609The risk or severity of adverse effects can be increased when Ibuprofen is combined with ME-609.Investigational
MebendazoleThe serum concentration of Ibuprofen can be increased when it is combined with Mebendazole.Approved, Vet Approved
Meclofenamic acidThe risk or severity of adverse effects can be increased when Meclofenamic acid is combined with Ibuprofen.Approved, Vet Approved
MedrysoneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Medrysone.Approved
Mefenamic acidThe risk or severity of adverse effects can be increased when Mefenamic acid is combined with Ibuprofen.Approved
MefloquineThe serum concentration of Ibuprofen can be increased when it is combined with Mefloquine.Approved
Megestrol acetateThe serum concentration of Ibuprofen can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MeloxicamThe risk or severity of adverse effects can be increased when Meloxicam is combined with Ibuprofen.Approved, Vet Approved
MeprobamateThe serum concentration of Ibuprofen can be increased when it is combined with Meprobamate.Approved, Illicit
MesalazineIbuprofen may increase the nephrotoxic activities of Mesalazine.Approved
MetamizoleThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Metamizole.Withdrawn
MethadoneThe serum concentration of Ibuprofen can be increased when it is combined with Methadone.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Ibuprofen.Approved
MethyclothiazideThe therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Ibuprofen.Approved
MethylprednisoloneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Methylprednisolone.Approved, Vet Approved
MetipranololIbuprofen may decrease the antihypertensive activities of Metipranolol.Approved
MetolazoneThe therapeutic efficacy of Metolazone can be decreased when used in combination with Ibuprofen.Approved
MetoprololThe serum concentration of Ibuprofen can be increased when it is combined with Metoprolol.Approved, Investigational
MetrizamideIbuprofen may decrease the excretion rate of Metrizamide which could result in a higher serum level.Approved
MibefradilThe serum concentration of Ibuprofen can be increased when it is combined with Mibefradil.Withdrawn
MiconazoleThe serum concentration of Ibuprofen can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Ibuprofen can be decreased when it is combined with Midazolam.Approved, Illicit
MifepristoneThe serum concentration of Ibuprofen can be increased when it is combined with Mifepristone.Approved, Investigational
MisoprostolThe therapeutic efficacy of Misoprostol can be decreased when used in combination with Ibuprofen.Approved
MitomycinThe serum concentration of Ibuprofen can be increased when it is combined with Mitomycin.Approved
MitoxantroneThe serum concentration of Ibuprofen can be decreased when it is combined with Mitoxantrone.Approved, Investigational
MoclobemideThe metabolism of Ibuprofen can be decreased when combined with Moclobemide.Approved
ModafinilThe metabolism of Ibuprofen can be decreased when combined with Modafinil.Approved, Investigational
MoexiprilThe risk or severity of adverse effects can be increased when Moexipril is combined with Ibuprofen.Approved
MometasoneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Mometasone.Approved, Vet Approved
MorniflumateThe risk or severity of adverse effects can be increased when Morniflumate is combined with Ibuprofen.Approved
MorphineThe serum concentration of Ibuprofen can be increased when it is combined with Morphine.Approved, Investigational
MoxifloxacinIbuprofen may increase the neuroexcitatory activities of Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Ibuprofen.Approved, Investigational
Mycophenolic acidThe risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Ibuprofen.Approved
NabumetoneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Nabumetone.Approved
NadololIbuprofen may decrease the antihypertensive activities of Nadolol.Approved
NadroparinIbuprofen may increase the anticoagulant activities of Nadroparin.Approved
NafamostatIbuprofen may increase the anticoagulant activities of Nafamostat.Approved, Investigational
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Ibuprofen.Approved
Nalidixic AcidIbuprofen may increase the neuroexcitatory activities of Nalidixic Acid.Approved
NaltrexoneThe serum concentration of Ibuprofen can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaproxenThe risk or severity of adverse effects can be increased when Naproxen is combined with Ibuprofen.Approved, Vet Approved
NaringeninThe serum concentration of Ibuprofen can be increased when it is combined with Naringenin.Experimental
NCX 1022The risk or severity of adverse effects can be increased when Ibuprofen is combined with NCX 1022.Investigational
NCX 4016The risk or severity of adverse effects can be increased when Ibuprofen is combined with NCX 4016.Investigational
NeamineIbuprofen may decrease the excretion rate of Neamine which could result in a higher serum level.Experimental
NefazodoneThe serum concentration of Ibuprofen can be decreased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Ibuprofen can be decreased when it is combined with Nelfinavir.Approved
NeomycinIbuprofen may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
NeostigmineThe serum concentration of Ibuprofen can be increased when it is combined with Neostigmine.Approved, Vet Approved
NepafenacThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Nepafenac.Approved
NetilmicinIbuprofen may decrease the excretion rate of Netilmicin which could result in a higher serum level.Approved
NicardipineThe metabolism of Ibuprofen can be decreased when combined with Nicardipine.Approved
NifedipineThe serum concentration of Ibuprofen can be decreased when it is combined with Nifedipine.Approved
Niflumic AcidThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Niflumic Acid.Approved
NilotinibThe serum concentration of Ibuprofen can be increased when it is combined with Nilotinib.Approved, Investigational
NimesulideThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Nimesulide.Approved, Withdrawn
NisoldipineThe serum concentration of Ibuprofen can be increased when it is combined with Nisoldipine.Approved
NitrazepamThe serum concentration of Ibuprofen can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe serum concentration of Ibuprofen can be increased when it is combined with Nitrendipine.Approved
NorethisteroneThe serum concentration of Ibuprofen can be decreased when it is combined with Norethisterone.Approved
NorfloxacinIbuprofen may increase the neuroexcitatory activities of Norfloxacin.Approved
OfloxacinIbuprofen may increase the neuroexcitatory activities of Ofloxacin.Approved
Oleoyl estroneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Oleoyl estrone.Investigational
OlmesartanThe risk or severity of adverse effects can be increased when Olmesartan is combined with Ibuprofen.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Ibuprofen.Approved
OlsalazineIbuprofen may increase the nephrotoxic activities of Olsalazine.Approved
Omacetaxine mepesuccinateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Omacetaxine mepesuccinate.Approved
OmapatrilatThe risk or severity of adverse effects can be increased when Omapatrilat is combined with Ibuprofen.Investigational
OmeprazoleThe serum concentration of Ibuprofen can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OxaprozinThe risk or severity of adverse effects can be increased when Oxaprozin is combined with Ibuprofen.Approved
OxprenololIbuprofen may decrease the antihypertensive activities of Oxprenolol.Approved
OxyphenbutazoneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Oxyphenbutazone.Withdrawn
P-NitrophenolThe serum concentration of Ibuprofen can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Ibuprofen can be increased when it is combined with Paclitaxel.Approved, Vet Approved
Palmitic AcidThe serum concentration of Ibuprofen can be increased when it is combined with Palmitic Acid.Experimental
PamidronateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Pamidronate.Approved
PantoprazoleThe serum concentration of Ibuprofen can be increased when it is combined with Pantoprazole.Approved
ParamethasoneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Paramethasone.Approved
ParecoxibThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Parecoxib.Approved
ParomomycinIbuprofen may decrease the excretion rate of Paromomycin which could result in a higher serum level.Approved, Investigational
ParoxetineThe serum concentration of Ibuprofen can be increased when it is combined with Paroxetine.Approved, Investigational
PefloxacinIbuprofen may increase the neuroexcitatory activities of Pefloxacin.Approved
PenbutololIbuprofen may decrease the antihypertensive activities of Penbutolol.Approved, Investigational
Pentosan PolysulfateIbuprofen may increase the anticoagulant activities of Pentosan Polysulfate.Approved
PerindoprilThe serum concentration of Ibuprofen can be increased when it is combined with Perindopril.Approved
PhenindioneIbuprofen may increase the anticoagulant activities of Phenindione.Approved
PhenobarbitalThe metabolism of Ibuprofen can be increased when combined with Phenobarbital.Approved
PhenprocoumonIbuprofen may increase the anticoagulant activities of Phenprocoumon.Approved
PhenylbutazoneThe risk or severity of adverse effects can be increased when Phenylbutazone is combined with Ibuprofen.Approved, Vet Approved
PhenytoinThe metabolism of Ibuprofen can be increased when combined with Phenytoin.Approved, Vet Approved
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Ibuprofen.Approved, Investigational
PimozideThe serum concentration of Ibuprofen can be increased when it is combined with Pimozide.Approved
PindololIbuprofen may decrease the antihypertensive activities of Pindolol.Approved
PioglitazoneThe metabolism of Ibuprofen can be decreased when combined with Pioglitazone.Approved, Investigational
PirarubicinIbuprofen may decrease the excretion rate of Pirarubicin which could result in a higher serum level.Investigational
PiretanideIbuprofen may decrease the diuretic activities of Piretanide.Experimental
PirfenidoneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Pirfenidone.Investigational
PiroxicamThe risk or severity of adverse effects can be increased when Piroxicam is combined with Ibuprofen.Approved, Investigational
Platelet Activating FactorThe serum concentration of Ibuprofen can be decreased when it is combined with Platelet Activating Factor.Experimental
PlicamycinIbuprofen may decrease the excretion rate of Plicamycin which could result in a higher serum level.Approved, Withdrawn
PolythiazideThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Ibuprofen.Approved
PonatinibThe serum concentration of Ibuprofen can be increased when it is combined with Ponatinib.Approved
PosaconazoleThe serum concentration of Ibuprofen can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PractololIbuprofen may decrease the antihypertensive activities of Practolol.Approved
PralatrexateThe serum concentration of Pralatrexate can be increased when it is combined with Ibuprofen.Approved
PrasteroneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Prasterone.Approved, Nutraceutical
Prasterone sulfateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with dehydroepiandrosterone sulfate.Investigational
PravastatinThe serum concentration of Ibuprofen can be increased when it is combined with Pravastatin.Approved
PrazosinThe serum concentration of Ibuprofen can be increased when it is combined with Prazosin.Approved
PrednicarbateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Prednicarbate.Approved
PrednisoloneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Prednisolone.Approved, Vet Approved
PrednisoneThe serum concentration of Ibuprofen can be increased when it is combined with Prednisone.Approved, Vet Approved
PregnenoloneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Pregnenolone.Experimental
PrimidoneThe metabolism of Ibuprofen can be increased when combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Ibuprofen can be increased when it is combined with Probenecid.Approved
ProgesteroneThe serum concentration of Ibuprofen can be decreased when it is combined with Progesterone.Approved, Vet Approved
PromethazineThe serum concentration of Ibuprofen can be increased when it is combined with Promethazine.Approved
PropacetamolThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Propacetamol.Approved
PropafenoneThe serum concentration of Ibuprofen can be increased when it is combined with Propafenone.Approved
PropranololThe serum concentration of Ibuprofen can be increased when it is combined with Propranolol.Approved, Investigational
Prostaglandin B2The therapeutic efficacy of Prostaglandin B2 can be decreased when used in combination with Ibuprofen.Experimental
Prostaglandin G2The therapeutic efficacy of Prostaglandin G2 can be decreased when used in combination with Ibuprofen.Experimental
Protein S humanIbuprofen may increase the anticoagulant activities of Protein S human.Approved
ProtriptylineThe serum concentration of Ibuprofen can be increased when it is combined with Protriptyline.Approved
PTC299The risk or severity of adverse effects can be increased when Ibuprofen is combined with PTC299.Investigational
PuromycinIbuprofen may decrease the excretion rate of Puromycin which could result in a higher serum level.Experimental
PyrimethamineThe metabolism of Ibuprofen can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuercetinThe serum concentration of Ibuprofen can be increased when it is combined with Quercetin.Experimental
QuinacrineThe serum concentration of Ibuprofen can be increased when it is combined with Quinacrine.Approved
QuinaprilThe risk or severity of adverse effects can be increased when Quinapril is combined with Ibuprofen.Approved, Investigational
QuinethazoneThe therapeutic efficacy of Quinethazone can be decreased when used in combination with Ibuprofen.Approved
QuinidineThe serum concentration of Ibuprofen can be increased when it is combined with Quinidine.Approved
QuinineThe serum concentration of Ibuprofen can be increased when it is combined with Quinine.Approved
RabeprazoleThe metabolism of Ibuprofen can be decreased when combined with Rabeprazole.Approved, Investigational
RamiprilThe risk or severity of adverse effects can be increased when Ramipril is combined with Ibuprofen.Approved
RanitidineThe serum concentration of Ibuprofen can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ibuprofen can be increased when it is combined with Ranolazine.Approved, Investigational
ReboxetineThe serum concentration of Ibuprofen can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibThe serum concentration of Ibuprofen can be increased when it is combined with Regorafenib.Approved
RescinnamineThe risk or severity of adverse effects can be increased when Rescinnamine is combined with Ibuprofen.Approved
ReserpineThe serum concentration of Ibuprofen can be decreased when it is combined with Reserpine.Approved
ResveratrolThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Resveratrol.Experimental, Investigational
ReviparinIbuprofen may increase the anticoagulant activities of Reviparin.Approved
RibostamycinIbuprofen may decrease the excretion rate of Ribostamycin which could result in a higher serum level.Approved
RifampicinThe metabolism of Ibuprofen can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Ibuprofen can be increased when combined with Rifapentine.Approved
RilpivirineThe serum concentration of Ibuprofen can be increased when it is combined with Rilpivirine.Approved
RimexoloneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Rimexolone.Approved
RisedronateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Risedronate.Approved, Investigational
RitonavirThe metabolism of Ibuprofen can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanIbuprofen may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Rofecoxib.Investigational, Withdrawn
RolapitantThe serum concentration of Ibuprofen can be increased when it is combined with Rolapitant.Approved
RosiglitazoneThe metabolism of Ibuprofen can be decreased when combined with Rosiglitazone.Approved, Investigational
RosoxacinIbuprofen may increase the neuroexcitatory activities of Rosoxacin.Approved
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Ibuprofen.Approved
SalicylamideThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Salicylamide.Approved
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Ibuprofen.Approved, Vet Approved
SalsalateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Salsalate.Approved
SaprisartanThe risk or severity of adverse effects can be increased when Saprisartan is combined with Ibuprofen.Experimental
SaquinavirThe serum concentration of Ibuprofen can be decreased when it is combined with Saquinavir.Approved, Investigational
ScopolamineThe serum concentration of Ibuprofen can be increased when it is combined with Scopolamine.Approved
SecobarbitalThe metabolism of Ibuprofen can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineThe serum concentration of Ibuprofen can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SertralineThe serum concentration of Ibuprofen can be increased when it is combined with Sertraline.Approved
SildenafilThe metabolism of Ibuprofen can be decreased when combined with Sildenafil.Approved, Investigational
SimeprevirThe serum concentration of Ibuprofen can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Ibuprofen can be increased when it is combined with Simvastatin.Approved
SirolimusThe serum concentration of Ibuprofen can be decreased when it is combined with Sirolimus.Approved, Investigational
SorafenibThe serum concentration of Ibuprofen can be increased when it is combined with Sorafenib.Approved, Investigational
SotalolIbuprofen may decrease the antihypertensive activities of Sotalol.Approved
SP1049CIbuprofen may decrease the excretion rate of SP1049C which could result in a higher serum level.Investigational
SparfloxacinIbuprofen may increase the neuroexcitatory activities of Sparfloxacin.Approved
SpectinomycinIbuprofen may decrease the excretion rate of Spectinomycin which could result in a higher serum level.Approved, Vet Approved
SpiraprilThe risk or severity of adverse effects can be increased when Spirapril is combined with Ibuprofen.Approved
SpironolactoneThe serum concentration of Ibuprofen can be increased when it is combined with Spironolactone.Approved
SRT501The risk or severity of adverse effects can be increased when Ibuprofen is combined with SRT501.Investigational
St. John's WortThe serum concentration of Ibuprofen can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Ibuprofen can be increased when it is combined with Staurosporine.Experimental
StiripentolThe metabolism of Ibuprofen can be decreased when combined with Stiripentol.Approved
StreptomycinIbuprofen may decrease the excretion rate of Streptomycin which could result in a higher serum level.Approved, Vet Approved
StreptozocinIbuprofen may decrease the excretion rate of Streptozocin which could result in a higher serum level.Approved
SulfadiazineThe metabolism of Ibuprofen can be decreased when combined with Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Ibuprofen can be decreased when combined with Sulfamethoxazole.Approved
SulfasalazineIbuprofen may increase the nephrotoxic activities of Sulfasalazine.Approved
SulfinpyrazoneThe serum concentration of Ibuprofen can be increased when it is combined with Sulfinpyrazone.Approved
SulfisoxazoleThe metabolism of Ibuprofen can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulindacThe risk or severity of adverse effects can be increased when Sulindac is combined with Ibuprofen.Approved
SulodexideIbuprofen may increase the anticoagulant activities of Sulodexide.Approved, Investigational
SumatriptanThe serum concentration of Ibuprofen can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Ibuprofen can be increased when it is combined with Sunitinib.Approved, Investigational
SuprofenThe risk or severity of adverse effects can be increased when Suprofen is combined with Ibuprofen.Approved, Withdrawn
TacrineThe serum concentration of Ibuprofen can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe serum concentration of Ibuprofen can be decreased when it is combined with Tacrolimus.Approved, Investigational
TacrolimusIbuprofen may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
TafluprostThe therapeutic efficacy of Tafluprost can be decreased when used in combination with Ibuprofen.Approved
TalniflumateThe risk or severity of adverse effects can be increased when Talniflumate is combined with Ibuprofen.Approved
TamoxifenThe serum concentration of Ibuprofen can be decreased when it is combined with Tamoxifen.Approved
TasosartanThe risk or severity of adverse effects can be increased when Tasosartan is combined with Ibuprofen.Approved
Taurocholic AcidThe serum concentration of Ibuprofen can be increased when it is combined with Taurocholic Acid.Experimental
Technetium Tc-99m medronateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Technetium Tc-99m Medronate.Approved
TelmisartanThe serum concentration of Ibuprofen can be increased when it is combined with Telmisartan.Approved, Investigational
TemafloxacinIbuprofen may increase the neuroexcitatory activities of Temafloxacin.Withdrawn
TemocaprilThe risk or severity of adverse effects can be increased when Temocapril is combined with Ibuprofen.Experimental, Investigational
TemsirolimusThe serum concentration of Ibuprofen can be increased when it is combined with Temsirolimus.Approved
TenofovirThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Tenofovir.Approved, Investigational
TenoxicamThe risk or severity of adverse effects can be increased when Tenoxicam is combined with Ibuprofen.Approved
TerazosinThe serum concentration of Ibuprofen can be increased when it is combined with Terazosin.Approved
TerfenadineThe serum concentration of Ibuprofen can be increased when it is combined with Terfenadine.Withdrawn
TeriflunomideThe metabolism of Ibuprofen can be decreased when combined with Teriflunomide.Approved
TesmilifeneThe serum concentration of Ibuprofen can be decreased when it is combined with Tesmilifene.Investigational
TestosteroneThe serum concentration of Ibuprofen can be increased when it is combined with Testosterone.Approved, Investigational
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Tiaprofenic acid.Approved
TicagrelorThe serum concentration of Ibuprofen can be increased when it is combined with Ticagrelor.Approved
TiclopidineThe metabolism of Ibuprofen can be decreased when combined with Ticlopidine.Approved
Tiludronic acidThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Tiludronate.Approved, Vet Approved
TimololIbuprofen may decrease the antihypertensive activities of Timolol.Approved
TixocortolThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Tixocortol.Approved
TobramycinIbuprofen may decrease the excretion rate of Tobramycin which could result in a higher serum level.Approved, Investigational
TolbutamideThe metabolism of Ibuprofen can be decreased when combined with Tolbutamide.Approved
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Tolfenamic Acid.Approved
TolmetinThe risk or severity of adverse effects can be increased when Tolmetin is combined with Ibuprofen.Approved
TolvaptanThe serum concentration of Ibuprofen can be increased when it is combined with Tolvaptan.Approved
TopiramateThe metabolism of Ibuprofen can be decreased when combined with Topiramate.Approved
TorasemideIbuprofen may decrease the diuretic activities of Torasemide.Approved
TrandolaprilThe risk or severity of adverse effects can be increased when Trandolapril is combined with Ibuprofen.Approved
TranilastThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Tranilast.Approved, Investigational
TranylcypromineThe metabolism of Ibuprofen can be decreased when combined with Tranylcypromine.Approved
TravoprostThe therapeutic efficacy of Travoprost can be decreased when used in combination with Ibuprofen.Approved
TrazodoneThe serum concentration of Ibuprofen can be decreased when it is combined with Trazodone.Approved, Investigational
TreprostinilThe risk or severity of adverse effects can be increased when Treprostinil is combined with Ibuprofen.Approved, Investigational
TriamcinoloneThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Triamcinolone.Approved, Vet Approved
TriamtereneIbuprofen may decrease the antihypertensive activities of Triamterene.Approved
TrichlormethiazideThe therapeutic efficacy of Trichlormethiazide can be decreased when used in combination with Ibuprofen.Approved, Vet Approved
TrifluoperazineThe serum concentration of Ibuprofen can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Ibuprofen can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethoprimThe serum concentration of Ibuprofen can be decreased when it is combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe serum concentration of Ibuprofen can be increased when it is combined with Trimipramine.Approved
TrovafloxacinIbuprofen may increase the neuroexcitatory activities of Trovafloxacin.Approved, Withdrawn
UnoprostoneThe therapeutic efficacy of Unoprostone can be decreased when used in combination with Ibuprofen.Approved
ValdecoxibThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Valdecoxib.Investigational, Withdrawn
Valproic AcidThe metabolism of Ibuprofen can be decreased when combined with Valproic Acid.Approved, Investigational
ValrubicinIbuprofen may decrease the excretion rate of Valrubicin which could result in a higher serum level.Approved
ValsartanThe metabolism of Ibuprofen can be decreased when combined with Valsartan.Approved, Investigational
VancomycinThe serum concentration of Vancomycin can be increased when it is combined with Ibuprofen.Approved
VenlafaxineThe serum concentration of Ibuprofen can be increased when it is combined with Venlafaxine.Approved
VerapamilThe serum concentration of Ibuprofen can be decreased when it is combined with Verapamil.Approved
VinblastineThe serum concentration of Ibuprofen can be decreased when it is combined with Vinblastine.Approved
VincristineThe serum concentration of Ibuprofen can be decreased when it is combined with Vincristine.Approved, Investigational
VinorelbineThe serum concentration of Ibuprofen can be increased when it is combined with Vinorelbine.Approved, Investigational
VoriconazoleThe serum concentration of Ibuprofen can be increased when it is combined with Voriconazole.Approved, Investigational
WarfarinIbuprofen may increase the anticoagulant activities of Warfarin.Approved
XimelagatranIbuprofen may increase the anticoagulant activities of Ximelagatran.Approved, Investigational, Withdrawn
ZafirlukastThe metabolism of Ibuprofen can be decreased when combined with Zafirlukast.Approved, Investigational
ZaltoprofenThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Zaltoprofen.Approved
ZileutonThe risk or severity of adverse effects can be increased when Zileuton is combined with Ibuprofen.Approved, Investigational, Withdrawn
ZimelidineThe serum concentration of Ibuprofen can be increased when it is combined with Zimelidine.Withdrawn
Zoledronic acidThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Zoledronic acid.Approved
ZomepiracThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Zomepirac.Withdrawn
ZorubicinIbuprofen may decrease the excretion rate of Zorubicin which could result in a higher serum level.Experimental
Food Interactions
  • Avoid alcohol
  • Food delays the time to reach peak plasma concentrations by 30-60 minutes and reduces peak plasma concentrations by 30-50%. Extent of absorption is unaffected.
  • Take with food to reduce gastric irritation.
References
Synthesis Reference

http://en.wikipedia.org/wiki/Ibuprofen#Synthesis

General References
  1. Zawada ET Jr: Renal consequences of nonsteroidal antiinflammatory drugs. Postgrad Med. 1982 May;71(5):223-30. [PubMed:7041104 ]
  2. Townsend KP, Pratico D: Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs. FASEB J. 2005 Oct;19(12):1592-601. [PubMed:16195368 ]
  3. Chen H, Jacobs E, Schwarzschild MA, McCullough ML, Calle EE, Thun MJ, Ascherio A: Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease. Ann Neurol. 2005 Dec;58(6):963-7. [PubMed:16240369 ]
  4. Geisslinger G, Dietzel K, Bezler H, Nuernberg B, Brune K: Therapeutically relevant differences in the pharmacokinetical and pharmaceutical behavior of ibuprofen lysinate as compared to ibuprofen acid. Int J Clin Pharmacol Ther Toxicol. 1989 Jul;27(7):324-8. [PubMed:2777420 ]
  5. Bergner T, Przybilla B: Photosensitization caused by ibuprofen. J Am Acad Dermatol. 1992 Jan;26(1):114-6. [PubMed:1531054 ]
  6. Dill J, Patel AR, Yang XL, Bachoo R, Powell CM, Li S: A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons. J Neurosci. 2010 Jan 20;30(3):963-72. doi: 10.1523/JNEUROSCI.5045-09.2010. [PubMed:20089905 ]
External Links
ATC CodesM02AA13C01EB16R02AX02M01AE51M01AE01G02CC01
AHFS Codes
  • 28:08.04.92
PDB EntriesNot Available
FDA labelDownload (1.77 MB)
MSDSDownload (73.5 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingBasic ScienceCancer, Breast1
0CompletedTreatmentPrimary Dysmenorrhoea1
0Enrolling by InvitationPreventionHypertensive1
0RecruitingTreatmentFracture, Ankle1
1Active Not RecruitingTreatmentSpinal Cord Injuries (SCI)1
1CompletedNot AvailableAutonomic Failure / Idiopathic orthostatic hypotension1
1CompletedNot AvailableBioequivalence1
1CompletedNot AvailableHealthy Volunteers8
1CompletedBasic ScienceHealthy Volunteer Study2
1CompletedBasic ScienceHealthy Volunteers5
1CompletedBasic ScienceHealthy Volunteers / Inflammatory Reaction / Pain1
1CompletedBasic ScienceInflammatory Reaction / Pain1
1CompletedBasic SciencePain4
1CompletedBasic SciencePharmacokinetics1
1CompletedPreventionGastroduodenal Erosions1
1CompletedTreatmentAcute Cystitis (Excl in Pregnancy)1
1CompletedTreatmentAllergic Rhinitis (AR)1
1CompletedTreatmentBioequivalency2
1CompletedTreatmentHealthy Volunteers11
1CompletedTreatmentNSAID Related Gastric Irritation1
1CompletedTreatmentOsteoarthritis of the Knees1
1CompletedTreatmentPain1
1CompletedTreatmentSynovitis of osteoarthritis1
1Not Yet RecruitingSupportive CareBalanitis / Paraphimosis / Phimosis / Postoperative pain1
1RecruitingTreatmentNeonates / Patent Ductus Arteriosus (PDA)1
1Unknown StatusBasic ScienceOsteoarthritis of the Knees1
1Unknown StatusBasic ScienceOther and unspecified effects of high altitude1
1Unknown StatusTreatmentAlzheimer's Disease (AD)1
1Unknown StatusTreatmentDuchenne's Muscular Dystrophy (DMD)1
1, 2CompletedTreatmentTemporomandibular Joint Disorders1
1, 2Enrolling by InvitationPreventionAnalgesic Drugs / Pain Relief1
1, 2Unknown StatusTreatmentChoroidal Melanoma / Eye Neoplasms / Melanoma1
1, 2Unknown StatusTreatmentInfant, Extremely Premature / IV Ibuprofen / Oral Ibuprofen / Patent Ductus Arteriosus (PDA)1
2Active Not RecruitingTreatmentDiabetes, Diabetes Mellitus Type 11
2Active Not RecruitingTreatmentImpacted Wisdom Teeth1
2CompletedNot AvailableComplication Due to Immunization1
2CompletedBasic ScienceSkeletal Muscle Mass Regulation1
2CompletedSupportive CareStomatitis, Aphthous1
2CompletedTreatmentAcute Sore Throat Pain1
2CompletedTreatmentCervical Strain1
2CompletedTreatmentContraception1
2CompletedTreatmentDelayed Onset Muscle Soreness1
2CompletedTreatmentDental Pain1
2CompletedTreatmentDysmenorrhea1
2CompletedTreatmentIrreversible Pulpitis / Pain / Postoperative pain1
2CompletedTreatmentMigraines1
2CompletedTreatmentPain6
2CompletedTreatmentPain, Acute1
2CompletedTreatmentPost-Operative Pain1
2CompletedTreatmentPostoperative Dental Pain1
2CompletedTreatmentPostoperative pain1
2CompletedTreatmentSoft Tissue Injury1
2CompletedTreatmentSynovitis of osteoarthritis1
2Enrolling by InvitationTreatmentTuberculosis1
2Not Yet RecruitingSupportive CareCarpal Tunnel Syndrome (CTS) / Cystic tumour of the ganglia / De Quervain's Disease / Dupuytren's Contracture / Trigger Digit1
2Not Yet RecruitingTreatmentConcussion, Brain1
2Not Yet RecruitingTreatmentPain Management1
2RecruitingBasic ScienceChronic Granulomatous Disease X-linked (X-CGD)1
2RecruitingPreventionFertilization in Vitro/Methods / Ovulation / Ovulation Inhibition / Ovulation Inhibition/Drug Effects / Pregnancy1
2RecruitingPreventionPost-ERCP Acute Pancreatitis1
2RecruitingPreventionRetinopathy of Prematurity1
2RecruitingSupportive CareCognitive Impairments / Stage 0 Colorectal Cancer / Stage I Colorectal Cancer / Stage II Colorectal Cancer / Stage IIA Colorectal Cancer / Stage IIB Colorectal Cancer / Stage IIC Colorectal Cancer / Stage III Colorectal Cancer / Stage IIIA Colorectal Cancer / Stage IIIB Colorectal Cancer / Stage IIIC Colorectal Cancer1
2RecruitingTreatmentAdenoidectomy / Tonsillectomy1
2RecruitingTreatmentBronchopulmonary Dysplasia (BPD)1
2RecruitingTreatmentCancer-related Cognitive Difficulties1
2RecruitingTreatmentCervical Spondylosis / Lumbar Spondylosis1
2RecruitingTreatmentDuctus Arteriosus, Patent1
2TerminatedTreatmentPost-surgical Dental Pain1
2TerminatedTreatmentPostsurgical Pain Due to Third Molar Extraction1
2Unknown StatusPreventionPost Bronchoscopy Fever1
2Unknown StatusPreventionSpectrum of Altitude-associated Neurologic Forms of Altitude1
2Unknown StatusSupportive CareMetastatic Cancers1
2Unknown StatusTreatmentImpacted Third Molar Tooth1
2WithdrawnTreatmentDental Pain1
2WithdrawnTreatmentHb-SS Disease With Vasoocclusive Pain / Hemoglobin SS Disease With Crisis / Hemoglobin SS Disease With Vasoocclusive Crisis / Other Sickle Cell Disease With Vaso-Occlusive Pain / Sickle Cell Disorders1
2WithdrawnTreatmentPatent Ductus Arteriosus (PDA)1
2, 3CompletedBasic ScienceMajor Depressive Disorder (MDD)1
2, 3CompletedSupportive CareHypertensive1
2, 3CompletedTreatmentCervicobrachial Neuralgia1
2, 3CompletedTreatmentDuctus Arteriosus, Patent1
2, 3CompletedTreatmentIdiopathic Intracranial Hypertension (IIH)1
2, 3CompletedTreatmentLow Back Pain (LBP)1
2, 3Not Yet RecruitingTreatmentPatent Ductus Arteriosus (PDA) / Respiratory Distress Syndrome (RDS)1
2, 3RecruitingTreatmentChronic Rhinosinusitis (Diagnosis)1
2, 3RecruitingTreatmentDuctus Arteriosus, Patent / Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants1
3Active Not RecruitingTreatmentAcute Ankle Sprain1
3Active Not RecruitingTreatmentCerebral Palsy (CP)1
3CompletedNot AvailablePain1
3CompletedPreventionAcute Kidney Injury (AKI) / Exercise-associated Hyponatremia / Perceived Exertion1
3CompletedPreventionAltitude Sickness1
3CompletedPreventionChronic Low Back Pain (CLBP) / Chronic Regional Pain Syndrome / Chronic Soft Tissue Pain / Rheumatoid Arthritis / Synovitis of osteoarthritis1
3CompletedPreventionIUD Removal1
3CompletedPreventionPeptic Ulcers1
3CompletedPreventionUlcers1
3CompletedTreatmentAcute Respiratory Distress Syndrome (ARDS) / Chronic Lung Diseases / Shock, Septic1
3CompletedTreatmentAcute Sore Throat Pain1
3CompletedTreatmentAsthma Bronchial / Wheezing1
3CompletedTreatmentDelayed Onset Muscle Soreness, DOMS1
3CompletedTreatmentDental Pain1
3CompletedTreatmentDysmenorrhea1
3CompletedTreatmentFevers3
3CompletedTreatmentFevers / Respiratory Tract Infections (RTI)1
3CompletedTreatmentForearm Fractures1
3CompletedTreatmentLow Back Pain (LBP)1
3CompletedTreatmentModerate or Severe Submental Fullness1
3CompletedTreatmentPain8
3CompletedTreatmentPain / Post-Operative Pain / Third Molar Extraction1
3CompletedTreatmentPain / Pregnancy1
3CompletedTreatmentPatent Ductus Arteriosus (PDA)1
3CompletedTreatmentPost Operative Dental Pain1
3CompletedTreatmentPost-Operative Pain1
3CompletedTreatmentPost-surgical Pain Following Extraction of Molar Teeth1
3CompletedTreatmentPostoperative Dental Pain1
3CompletedTreatmentPostoperative pain1
3CompletedTreatmentPostoperative pain / Tooth Diseases1
3CompletedTreatmentPrimary Dysmenorrhoea1
3CompletedTreatmentTonsillectomy1
3CompletedTreatmentMinor burns1
3CompletedTreatmentSynovitis of osteoarthritis1
3Not Yet RecruitingTreatmentCold1
3Not Yet RecruitingTreatmentFlu Symptoms2
3Not Yet RecruitingTreatmentHernia / Pain1
3Not Yet RecruitingTreatmentPain1
3RecruitingSupportive CareMalignant Head and Neck Neoplasm / Mucositis / Radiation-Induced Disorder1
3RecruitingTreatmentAlzheimer's Disease (AD)1
3RecruitingTreatmentBack Pain / Cervical Pain1
3RecruitingTreatmentFevers1
3RecruitingTreatmentLong-bone Fractures / Pain1
3RecruitingTreatmentPatent Ductus Arteriosus (PDA)3
3RecruitingTreatmentPost Operative Pain1
3TerminatedTreatmentDysmenorrhea1
3TerminatedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
3TerminatedTreatmentInfection NOS1
3TerminatedTreatmentModerate to Severe Primary Dysmenorrhea1
3TerminatedTreatmentPostoperative pain1
3Unknown StatusSupportive CarePostoperative pain1
3Unknown StatusTreatmentHeadaches1
3Unknown StatusTreatmentMuscular Atrophy / Sprains / Tendonitis1
3Unknown StatusTreatmentNeoplasms, Breast1
3Unknown StatusTreatmentPediatric Obstructive Sleep Apnea Syndrome1
3WithdrawnTreatmentPain1
3WithdrawnTreatmentAcute Rhinitis1
3WithdrawnTreatmentSynovitis of osteoarthritis1
4Active Not RecruitingPreventionPain, Acute / Postoperative pain1
4CompletedNot AvailablePatent Ductus Arteriosus (PDA) / Prematurity of Fetus1
4CompletedBasic ScienceHealthy Volunteers2
4CompletedBasic ScienceIschaemic Heart Diseases / Synovitis of osteoarthritis1
4CompletedBasic SciencePain1
4CompletedPreventionAcute Mountain Sickness, Blood Oxygen Saturation, Headache1
4CompletedPreventionArthroplasty, Replacement, Hip / Osteoarthritis, Hip / Rheumatoid Arthritis1
4CompletedPreventionPain Measurement1
4CompletedPreventionRecurrence of Febrile Seizure1
4CompletedPreventionRheumatoid Arthritis / Synovitis of osteoarthritis1
4CompletedPreventionStreptococcal Infections1
4CompletedPreventionVaccines, Pneumococcal1
4CompletedSupportive CareCongenital Muscular Torticollis1
4CompletedSupportive CareOrthodontic Pain1
4CompletedSupportive CarePain1
4CompletedSupportive CarePain / Pituitary Neoplasms1
4CompletedSupportive CareSymptomatic Uterine Fibroids and Adenomyosis1
4CompletedTreatmentAlzheimer's Disease (AD)1
4CompletedTreatmentAnalgesia / Postoperative pain1
4CompletedTreatmentAnalgesics1
4CompletedTreatmentArthroscopic Knee Surgery1
4CompletedTreatmentBMI >30 kg/m21
4CompletedTreatmentBariatric Surgery Candidate / Obesity, Morbid1
4CompletedTreatmentBreast Pain1
4CompletedTreatmentChronic Low Back Pain (CLBP)1
4CompletedTreatmentDental Pain1
4CompletedTreatmentFeeling Anxious / Nausea / Pain1
4CompletedTreatmentFevers3
4CompletedTreatmentFevers / Pain1
4CompletedTreatmentGallbladder disorders1
4CompletedTreatmentGastrointestinal Mucosal Damage1
4CompletedTreatmentGeneral Surgery1
4CompletedTreatmentHeadache, Tension-Type / Headaches / Tension-Type Headache (Episodic)1
4CompletedTreatmentHypertensive1
4CompletedTreatmentImpaired Renal Function / Myocardial Infarction (MI) / Postoperative pain1
4CompletedTreatmentInfants, Premature / Patent Ductus Arteriosus (PDA)1
4CompletedTreatmentIrreversible Pulpitis1
4CompletedTreatmentJuvenile Idiopathic Arthritis (JIA)1
4CompletedTreatmentMigrainous Headache1
4CompletedTreatmentMosquito Bites1
4CompletedTreatmentNarcotic Use / Nausea / Occasional Constipation / Pain1
4CompletedTreatmentOsteoarthritis of the Hip or Knee1
4CompletedTreatmentOsteoarthritis of the Knees4
4CompletedTreatmentPain6
4CompletedTreatmentPatent Ductus Arteriosus (PDA)2
4CompletedTreatmentPostoperative pain1
4CompletedTreatmentRelapsing Remitting Multiple Sclerosis (RRMS)1
4CompletedTreatmentRheumatoid Arthritis1
4CompletedTreatmentRotator Cuff Syndrome1
4CompletedTreatmentTraumas1
4CompletedTreatmentUrinary Tract Infections (UTIs)1
4Enrolling by InvitationTreatmentCarpal Tunnel / Cystic tumour of the ganglia / De Quervain's Disease / Trigger Finger1
4Not Yet RecruitingTreatmentAnalgesia / Percutaneous Nephrolithotomy1
4Not Yet RecruitingTreatmentAnalgesics, Opioid / Anti-Inflammatory Agents, Non-Steroidal / Child/Adolescent Problems / Emergency Service, Hospital / Fentanyl / Ibuprofen / Pain, Acute1
4Not Yet RecruitingTreatmentArthritic Knee Pain1
4Not Yet RecruitingTreatmentFevers / Pain1
4Not Yet RecruitingTreatmentLow Back Pain (LBP)1
4Not Yet RecruitingTreatmentPain1
4RecruitingHealth Services ResearchPain1
4RecruitingPreventionAnaesthesia therapy / Hip Fractures1
4RecruitingSupportive CareCarpal Tunnel1
4RecruitingTreatmentAcute Diverticulitis1
4RecruitingTreatmentCervical Preparation / Pain / Pregnancy Termination1
4RecruitingTreatmentEclampsia / HELLP Syndrome / Prophylaxis of preeclampsia1
4RecruitingTreatmentEpisodic Migraine1
4RecruitingTreatmentFlu caused by Influenza1
4RecruitingTreatmentFracture Bone1
4RecruitingTreatmentHypertension, Pregnancy-Induced / Prophylaxis of preeclampsia1
4RecruitingTreatmentLow Back Pain (LBP)1
4RecruitingTreatmentLumbar Disc Disease / Lumbar Radiculopathy / Prolapsed Lumbar Disc1
4RecruitingTreatmentPain1
4RecruitingTreatmentPain, Acute1
4RecruitingTreatmentPostoperative pain3
4RecruitingTreatmentRib Fractures / Wounds and Injuries1
4RecruitingTreatmentSciatica1
4SuspendedTreatmentRotator Cuff Syndrome1
4TerminatedTreatmentAdverse Reaction to Drug / Obstructive Sleep Apnea (OSA) / Recurrent Tonsillitis / Sleep Disordered Breathing (SDB)1
4TerminatedTreatmentDepression, Myalgia / Depressive State1
4TerminatedTreatmentHematologic Diseases / Sickle Cell Disorders1
4TerminatedTreatmentInflammatory Responses1
4TerminatedTreatmentPain1
4TerminatedTreatmentPatent Ductus Arteriosus (PDA)1
4TerminatedTreatmentPeriodontitis1
4TerminatedTreatmentSickle Cell Disorders1
4Unknown StatusDiagnosticPatent Ductus Arteriosus (PDA)1
4Unknown StatusSupportive CareChronic Pelvic Pain1
4Unknown StatusTreatmentDental Extraction1
4Unknown StatusTreatmentFevers3
4Unknown StatusTreatmentHeat / Pain1
4Unknown StatusTreatmentPharyngitis1
4WithdrawnTreatmentDuctus Arteriosus, Patent / Very Low Birth Weight Infants1
Not AvailableActive Not RecruitingTreatmentColles Fracture1
Not AvailableActive Not RecruitingTreatmentSpinal Stenosis of Lumbar Region1
Not AvailableCompletedNot AvailableAging / Physical Fitness1
Not AvailableCompletedNot AvailableConcussions / Headaches1
Not AvailableCompletedBasic ScienceAsthma, Allergic1
Not AvailableCompletedBasic ScienceBMI >30 kg/m21
Not AvailableCompletedBasic ScienceIschemic Reperfusion Injury1
Not AvailableCompletedBasic SciencePlatelet Aggregation1
Not AvailableCompletedDiagnosticCystic Fibrosis (CF) / Diabetes Mellitus (DM)1
Not AvailableCompletedDiagnosticDermatitis, Photocontact1
Not AvailableCompletedPreventionCardiovascular Disease (CVD)1
Not AvailableCompletedPreventionPostoperative pain / Wisdom Tooth1
Not AvailableCompletedPreventionBone destruction / Sarcopenia1
Not AvailableCompletedSupportive CareElbow Fractures1
Not AvailableCompletedSupportive CareHyperalgesia / Ibuprofen / Postoperative pain / Remifentanil1
Not AvailableCompletedTreatmentAnalgesia Post Fracture / Upper Extremity Fractures1
Not AvailableCompletedTreatmentCancer, Breast1
Not AvailableCompletedTreatmentCystic Fibrosis (CF)2
Not AvailableCompletedTreatmentDiverticulitis1
Not AvailableCompletedTreatmentDysmenorrhea1
Not AvailableCompletedTreatmentFracture Bone1
Not AvailableCompletedTreatmentGlaucoma / Ocular Hypertension1
Not AvailableCompletedTreatmentHemophilia A / Human Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedTreatmentHernia, Abdominal / Inguinal Hernias / Laparoscopic Cholecystectomy / Umbilical Hernias1
Not AvailableCompletedTreatmentHypoxic Ischemic Encephalopathy (HIE) / Perinatal Asphyxia1
Not AvailableCompletedTreatmentLow Back Pain (LBP)1
Not AvailableCompletedTreatmentMusculoskeletal Injuries1
Not AvailableCompletedTreatmentOsteoarthritis Of Knee1
Not AvailableCompletedTreatmentOsteoarthritis of the Knees3
Not AvailableCompletedTreatmentPain3
Not AvailableCompletedTreatmentPatent Ductus Arteriosus (PDA)3
Not AvailableCompletedTreatmentPneumonia1
Not AvailableCompletedTreatmentSkin Laxity1
Not AvailableCompletedTreatmentSpondyloarthritis, Axial1
Not AvailableCompletedTreatmentTemporomandibular Disorders1
Not AvailableEnrolling by InvitationSupportive CareInfertilities / Subfertility1
Not AvailableNot Yet RecruitingTreatmentInguinal Surgery1
Not AvailableNot Yet RecruitingTreatmentPain1
Not AvailableNot Yet RecruitingTreatmentPatent Ductus Arteriosus (PDA)1
Not AvailableRecruitingNot AvailableMultimodal Analgesia / Nonsteroidal Anti-inflammatory Drugs1
Not AvailableRecruitingBasic ScienceStability & Variability of Lipid-derived Molecules in Sweat1
Not AvailableRecruitingPreventionCachexia / Neoplasms1
Not AvailableRecruitingPreventionDisorder of Urinary Stent / Ureteral Spasm / Ureteropelvic Junction Obstruction / Urolithiasis1
Not AvailableRecruitingPreventionImmune System and Related Disorders1
Not AvailableRecruitingTreatmentBiliary Colic1
Not AvailableRecruitingTreatmentHigh Altitude Headache / Other and unspecified effects of high altitude1
Not AvailableRecruitingTreatmentHypertension, Pregnancy-Induced1
Not AvailableRecruitingTreatmentPatent Ductus Arteriosus (PDA)1
Not AvailableRecruitingTreatmentPostoperative pain1
Not AvailableRecruitingTreatmentRotator Cuff Tear Arthropathy1
Not AvailableSuspendedTreatmentLaceration / Pain1
Not AvailableTerminatedPreventionPain1
Not AvailableTerminatedTreatmentCachexia / Cancer, Advanced1
Not AvailableTerminatedTreatmentDuctus Arteriosus, Patent / Preterm Infants1
Not AvailableTerminatedTreatmentPatent Ductus Arteriosus (PDA) / Premature Babies1
Not AvailableTerminatedTreatmentSevere Traumatic Brain Injury / Subarachnoid Hemorrhage1
Not AvailableTerminatedTreatmentSoft Tissue Injury1
Not AvailableUnknown StatusNot AvailableAnti Inflammatory Non-Steroidal / Cystic Fibrosis (CF) / Neutrophils1
Not AvailableUnknown StatusNot AvailableFevers1
Not AvailableUnknown StatusBasic ScienceMalignant Neoplasm of Colon1
Not AvailableUnknown StatusPreventionOral Ibuprofen Prophylaxis in Very Low Birth Weight Infants1
Not AvailableUnknown StatusSupportive CarePrimary Post Tonsillectomy Hemorrhage / Secondary Post Tonsillectomy Hemorrhage1
Not AvailableUnknown StatusTreatmentFevers1
Not AvailableUnknown StatusTreatmentFlail Chest / General Surgery / Rib Fractures / Traumas1
Not AvailableUnknown StatusTreatmentFracture Bone / Pain1
Not AvailableUnknown StatusTreatmentPain1
Not AvailableUnknown StatusTreatmentPleuro-pneumonia1
Not AvailableWithdrawnSupportive CareToothache1
Not AvailableWithdrawnTreatmentPsychiatric Disorder NOS1
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tablet, extended releaseOral600 mg
CapsuleOral
Capsule; kitOral
CapsuleOral400 mg
CapsuleOral200 mg
Tablet, coatedOral256 mg/1
TabletOral400 mg/400mg
TabletOral600 mg/600mg
TabletOral800 mg/800mg
TabletOral300 mg
TabletOral200 mg
InjectionIntravenous800 mg/8mL
SolutionIntravenous100 mg
TabletOral200 mg/1
SuspensionOral100 mg
Tablet, chewableOral50 mg
TabletOral50 mg
SolutionOral100 mg/5mL
SuspensionOral200 mg/10mL
Kit; tabletOral
Kit
KitOral; Topical
SuspensionOral
Capsule, liquid filledOral200 mg/1
Tablet, chewableOral100 mg/1
Tablet, coatedOral200 mg/1
Tablet, film coatedOral200 mg/1
SuspensionOral100 mg/5mL
Tablet, sugar coatedOral
SuspensionOral50 mg/1.25mL
Tablet, coatedOral
TabletOral600 mg/1
TabletOral800 mg/1
Capsule, coatedOral200 mg/1
Capsule, liquid filledOral220 mg/1
LiquidOral100 mg/5mL
Suspension / dropsOral50 mg/1.25mL
TabletOral100 mg/1
TabletOral400 mg/1
TabletOral800 1/1
Tablet, coatedOral400 mg/1
Tablet, coatedOral600 mg/1
Tablet, coatedOral800 mg/1
Tablet, film coatedOral200 1/1
Tablet, film coatedOral400 mg/1
Tablet, film coatedOral400 mg/400mg
Tablet, film coatedOral400 mg/301
Tablet, film coatedOral600 mg/600mg
Tablet, film coatedOral600 mg/1
Tablet, film coatedOral800 mg/1
Tablet, film coatedOral800 mg/800mg
CapsuleOral200 mg/1
Capsule, liquid filledOral
Tablet, film coatedOral256 mg/1
SuspensionOral40 mg
Tablet, chewableOral100 mg
Tablet, coatedOral100 mg/1
TabletOral100 mg
Kit
SolutionIntravenous10 mg/mL
Injection, solutionIntravenous5 mg/ml
LiquidOral50 mg/1.25mL
TabletOral400 mg
TabletOral600 mg
KitOral
TabletOral400 mg/537mg
Tablet, sugar coatedOral200 mg/1
Tablet, film coatedOral200 1/2001
TabletOral
Tablet, film coatedOral
Prices
Unit descriptionCostUnit
Neoprofen 20 mg/2 ml vial304.5USD ml
Caldolor 400 mg/4 ml vial2.21USD ml
Caldolor 800 mg/8 ml vial1.58USD ml
Nuprin arthritis patch1.11USD patch
Ibuprofen powder1.04USD g
Nuprin muscle & joint patch1.03USD patch
Profen II 45-800 mg 12 Hour tablet0.69USD tablet
Motrin 800 mg tablet0.59USD tablet
Advil allergy sinus caplet0.5USD caplet
Ibu-drops 40 mg/ml suspension drops0.42USD ml
Motrin 600 mg tablet0.4USD tablet
Ibuprofen 800 mg tablet0.36USD tablet
Ibuprofen 400 mg tablet0.35USD tablet
Infant's motrin 50 mg/1.25 ml0.34USD ml
Childs ibuprofen susp drp0.33USD ml
Ibuprofen 600 mg tablet0.33USD tablet
Wal-profen cold & sinus cplt0.3USD caplet
Infant ibuprofen susp drop0.29USD ml
Motrin 400 mg tablet0.29USD tablet
CVS Pharmacy infant ibuprofen susp drop0.25USD ml
Infants medi-profen susp0.23USD ml
Advil cold & sinus caplet0.22USD caplet
Advil pm caplet0.22USD caplet
Soba profen cold-sinus tablet0.22USD tablet
Midol caplet0.21USD caplet
Advil migraine 200 mg capsule0.2USD capsule
Ibuprofen cold-sinus caplet0.2USD caplet
Motrin 100 mg caplet0.2USD caplet
Motrin pm caplet0.2USD caplet
Advil 200 mg liqui-gel capsule0.19USD capsule
Soba profen ib caplet0.19USD caplet
Motrin 100 mg tablet chew0.18USD tablet
Pub infants profenib drops0.18USD ml
Sm ibuprofen ib 100 mg tablet0.18USD tablet
Eck ibuprofen jr caplet0.17USD caplet
Ibuprofen pm caplet0.17USD caplet
Advil 200 mg caplet0.15USD capsule
Advil 200 mg gel caplet0.15USD caplet
Advil 200 mg tablet0.15USD tablet
Ibuprofen 100 mg tablet chew0.15USD tablet
Motrin ib 200 mg caplet0.15USD caplet
Apo-Ibuprofen 600 mg Tablet0.14USD tablet
CVS Pharmacy ibuprofen jr str 100 mg tablet0.14USD tablet
Nu-Ibuprofen 600 mg Tablet0.14USD tablet
Motrin ib 200 mg tablet0.13USD tablet
Motrin ib 200 mg gelcap0.12USD capsule
Nuprin 200 mg caplet0.12USD caplet
Wal-profen 200 mg caplet0.12USD caplet
Wal-profen 200 mg tablet0.12USD tablet
Eql ibuprofen 200 mg tablet0.1USD tablet
Nuprin 200 mg tablet0.1USD tablet
Apo-Ibuprofen 400 mg Tablet0.08USD tablet
Ibuprofen ib 200 mg tablet0.08USD tablet
Novo-Profen 400 mg Tablet0.08USD tablet
Apo-Ibuprofen 300 mg Tablet0.07USD tablet
Medi-profen 200 mg tablet0.07USD tablet
Ibuprofen 100 mg/5ml Suspension0.06USD ml
Ibuprofen 200 mg caplet0.06USD caplet
Child ibuprofen susp0.05USD ml
Children's medi-profen susp0.05USD ml
Children's motrin cold suspension0.05USD ml
CVS Pharmacy ibuprofen 200 mg tablet0.05USD tablet
Ibuprofen cold suspension0.05USD ml
I-prin 200 mg tablet0.05USD tablet
Novo-Profen 600 mg Tablet0.05USD tablet
Children's motrin cold0.04USD ml
Pv ibuprofen 200 mg caplet0.04USD caplet
Soba children's profenib susp0.04USD ml
Ibuprofen 200 mg tablet0.03USD tablet
CVS Pharmacy ibuprofen 200 mg caplet0.02USD caplet
Pv ibuprofen 200 mg tablet0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5215755 No1993-06-012010-06-01Us
US6211246 No1999-06-102019-06-10Us
US6251426 No1998-06-252018-06-25Us
US6342530 No2000-11-142020-11-14Us
US6344479 No2001-03-202021-03-20Us
US6348216 No1997-06-102017-06-10Us
US6599531 No1997-06-102017-06-10Us
US6727286 No2001-11-272021-11-27Us
US7863287 No2007-02-282027-02-28Us
US8067033 No2006-07-182026-07-18Us
US8067451 No2006-07-182026-07-18Us
US8263647 No2002-05-302022-05-30Us
US8309127 No2006-07-182026-07-18Us
US8318202 No2006-07-182026-07-18Us
US8415337 No2012-03-022032-03-02Us
US8449910 No2006-07-182026-07-18Us
US8501228 No2006-07-182026-07-18Us
US8735452 No2009-09-302029-09-30Us
US8871810 No2009-09-302029-09-30Us
US8883849 No2002-01-172022-01-17Us
US9012508 No2010-09-142030-09-14Us
US9114068 No2009-09-302029-09-30Us
US9138404 No2009-09-302029-09-30Us
US9155718 No2002-01-172022-01-17Us
US9295639 No2009-09-302029-09-30Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point (°C)75-77.5U.S. Patent 3,228,831 U.S. Patent 3,385,886
water solubility21 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP3.97AVDEEF,A (1997)
logS-3.99ADME Research, USCD
Caco2 permeability-4.28ADME Research, USCD
pKa4.91SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0684 mg/mLALOGPS
logP3.5ALOGPS
logP3.84ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)4.85ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area37.3 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity60.73 m3·mol-1ChemAxon
Polarizability23.76 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9927
Blood Brain Barrier+0.9619
Caco-2 permeable+0.8866
P-glycoprotein substrateNon-substrate0.759
P-glycoprotein inhibitor INon-inhibitor0.9705
P-glycoprotein inhibitor IINon-inhibitor0.9323
Renal organic cation transporterNon-inhibitor0.9323
CYP450 2C9 substrateNon-substrate0.7594
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.6877
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9305
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9881
CYP450 3A4 inhibitorNon-inhibitor0.9655
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9691
Ames testNon AMES toxic0.9894
CarcinogenicityCarcinogens 0.5553
BiodegradationReady biodegradable0.5142
Rat acute toxicity2.3092 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9719
hERG inhibition (predictor II)Non-inhibitor0.9734
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Download (11.4 KB)
Spectra
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (1 TMS)splash10-02t9-1910000000-23f448d7be7d5cc35682View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (1 TMS)splash10-02t9-1910000000-cbe52d63986b68a2cec0View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (1 TMS)splash10-00di-9300000000-cc259b7768023e4cdba8View in MoNA
GC-MSGC-MS Spectrum - EI-Bsplash10-03di-3910000000-618880f8fd7b8ec3d473View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-03di-0910000000-90bf6813134491c9fbfdView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-001i-9800000000-56f599abc462380b648cView in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI RMU-6E) , Positivesplash10-03di-3910000000-618880f8fd7b8ec3d473View in MoNA
LC-MS/MSLC-MS/MS Spectrum - , positivesplash10-03di-1900000000-f1b7a986fee133d97eb1View in MoNA
LC-MS/MSLC-MS/MS Spectrum - , positivesplash10-03di-0920000000-aa36b3244e32560bb9d5View in MoNA
MSMass Spectrum (Electron Ionization)splash10-03xr-3900000000-e20ef3c30496e17720baView in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpropanoic acids. These are compounds with a structure containing a benzene ring conjugated to a propanoic acid.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassPhenylpropanoic acids
Sub ClassNot Available
Direct ParentPhenylpropanoic acids
Alternative ParentsMonocyclic monoterpenoids / Aromatic monoterpenoids / Phenylpropanes / Monocarboxylic acids and derivatives / Carboxylic acids / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents2-phenylpropanoic-acid / P-cymene / Aromatic monoterpenoid / Monocyclic monoterpenoid / Monoterpenoid / Phenylpropane / Monocyclic benzene moiety / Benzenoid / Monocarboxylic acid or derivatives / Carboxylic acid
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptorsmonocarboxylic acid (CHEBI:5855 )

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, p...
Gene Name:
PTGS2
Uniprot ID:
P35354
Molecular Weight:
68995.625 Da
References
  1. Chavez ML, DeKorte CJ: Valdecoxib: a review. Clin Ther. 2003 Mar;25(3):817-51. [PubMed:12852704 ]
  2. Ouellet M, Falgueyret JP, Percival MD: Detergents profoundly affect inhibitor potencies against both cyclo-oxygenase isoforms. Biochem J. 2004 Feb 1;377(Pt 3):675-84. [PubMed:14510637 ]
  3. Gallego-Sandin S, Novalbos J, Rosado A, Gisbert JP, Galvez-Mugica MA, Garcia AG, Pajares JM, Abad-Santos F: Effect of ibuprofen on cyclooxygenase and nitric oxide synthase of gastric mucosa: correlation with endoscopic lesions and adverse reactions. Dig Dis Sci. 2004 Sep;49(9):1538-44. [PubMed:15481334 ]
  4. Murphey LJ, Williams MK, Sanchez SC, Byrne LM, Csiki I, Oates JA, Johnson DH, Morrow JD: Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer. Anal Biochem. 2004 Nov 15;334(2):266-75. [PubMed:15494133 ]
  5. Sanchez-Fidalgo S, Martin-Lacave I, Illanes M, Motilva V: Angiogenesis, cell proliferation and apoptosis in gastric ulcer healing. Effect of a selective cox-2 inhibitor. Eur J Pharmacol. 2004 Nov 28;505(1-3):187-94. [PubMed:15556152 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the gener...
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular Weight:
68685.82 Da
References
  1. Chavez ML, DeKorte CJ: Valdecoxib: a review. Clin Ther. 2003 Mar;25(3):817-51. [PubMed:12852704 ]
  2. Patrignani P: Aspirin insensitive eicosanoid biosynthesis in cardiovascular disease. Thromb Res. 2003 Jun 15;110(5-6):281-6. [PubMed:14592549 ]
  3. Gupta K, Kaub CJ, Carey KN, Casillas EG, Selinsky BS, Loll PJ: Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors. Bioorg Med Chem Lett. 2004 Feb 9;14(3):667-71. [PubMed:14741265 ]
  4. Martic M, Tatic I, Markovic S, Kujundzic N, Kostrun S: Synthesis, biological activity and molecular modeling studies of novel COX-1 inhibitors. Eur J Med Chem. 2004 Feb;39(2):141-51. [PubMed:14987823 ]
  5. Hillarp A: [Acetylsalicylic acid resistance--clinical diagnosis with unclear mechanism]. Lakartidningen. 2004 Nov 4;101(45):3504-6, 3508-9. [PubMed:15575422 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  7. Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. [PubMed:23536207 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
modulator
General Function:
Ubiquitin protein ligase binding
Specific Function:
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating f...
Gene Name:
BCL2
Uniprot ID:
P10415
Molecular Weight:
26265.66 Da
References
  1. Palayoor ST, J-Aryankalayil M, Makinde AY, Cerna D, Falduto MT, Magnuson SR, Coleman CN: Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012 Jun;59(6):487-99. doi: 10.1097/FJC.0b013e31824ba6b5. [PubMed:22668799 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
modulator
General Function:
Transmembrane signaling receptor activity
Specific Function:
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Gene Name:
THBD
Uniprot ID:
P07204
Molecular Weight:
60328.72 Da
References
  1. Palayoor ST, J-Aryankalayil M, Makinde AY, Cerna D, Falduto MT, Magnuson SR, Coleman CN: Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012 Jun;59(6):487-99. doi: 10.1097/FJC.0b013e31824ba6b5. [PubMed:22668799 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
negative modulator
General Function:
Serine-type endopeptidase activity
Specific Function:
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
Gene Name:
PLAT
Uniprot ID:
P00750
Molecular Weight:
62916.495 Da
References
  1. Palayoor ST, J-Aryankalayil M, Makinde AY, Cerna D, Falduto MT, Magnuson SR, Coleman CN: Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012 Jun;59(6):487-99. doi: 10.1097/FJC.0b013e31824ba6b5. [PubMed:22668799 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Transporter activity
Specific Function:
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
Gene Name:
FABP2
Uniprot ID:
P12104
Molecular Weight:
15207.165 Da
References
  1. Velkov T, Chuang S, Wielens J, Sakellaris H, Charman WN, Porter CJ, Scanlon MJ: The interaction of lipophilic drugs with intestinal fatty acid-binding protein. J Biol Chem. 2005 May 6;280(18):17769-76. Epub 2005 Feb 18. [PubMed:15722357 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
activator
General Function:
Zinc ion binding
Specific Function:
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation...
Gene Name:
PPARG
Uniprot ID:
P37231
Molecular Weight:
57619.58 Da
References
  1. Dill J, Patel AR, Yang XL, Bachoo R, Powell CM, Li S: A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons. J Neurosci. 2010 Jan 20;30(3):963-72. doi: 10.1523/JNEUROSCI.5045-09.2010. [PubMed:20089905 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Pdz domain binding
Specific Function:
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Gene Name:
CFTR
Uniprot ID:
P13569
Molecular Weight:
168139.895 Da
References
  1. Devor DC, Schultz BD: Ibuprofen inhibits cystic fibrosis transmembrane conductance regulator-mediated Cl- secretion. J Clin Invest. 1998 Aug 15;102(4):679-87. [PubMed:9710435 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Mo SL, Zhou ZW, Yang LP, Wei MQ, Zhou SF: New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126. [PubMed:20167001 ]
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  4. Carlile DJ, Hakooz N, Bayliss MK, Houston JB: Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans. Br J Clin Pharmacol. 1999 Jun;47(6):625-35. [PubMed:10383540 ]
  5. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. [PubMed:23536207 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naph...
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular Weight:
59590.91 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Retinoic acid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Gene Name:
UGT1A3
Uniprot ID:
P35503
Molecular Weight:
60337.835 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Retinoic acid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Gene Name:
UGT1A9
Uniprot ID:
O60656
Molecular Weight:
59940.495 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Glucuronosyltransferase activity
Specific Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydr...
Gene Name:
UGT2B4
Uniprot ID:
P06133
Molecular Weight:
60512.035 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Glucuronosyltransferase activity
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol...
Gene Name:
UGT2B7
Uniprot ID:
P16662
Molecular Weight:
60694.12 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the gener...
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular Weight:
68685.82 Da
References
  1. Palayoor ST, J-Aryankalayil M, Makinde AY, Cerna D, Falduto MT, Magnuson SR, Coleman CN: Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012 Jun;59(6):487-99. doi: 10.1097/FJC.0b013e31824ba6b5. [PubMed:22668799 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, p...
Gene Name:
PTGS2
Uniprot ID:
P35354
Molecular Weight:
68995.625 Da
References
  1. Palayoor ST, J-Aryankalayil M, Makinde AY, Cerna D, Falduto MT, Magnuson SR, Coleman CN: Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012 Jun;59(6):487-99. doi: 10.1097/FJC.0b013e31824ba6b5. [PubMed:22668799 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Yamasaki K, Rahman MH, Tsutsumi Y, Maruyama T, Ahmed S, Kragh-Hansen U, Otagiri M: Circular dichroism simulation shows a site-II-to-site-I displacement of human serum albumin-bound diclofenac by ibuprofen. AAPS PharmSciTech. 2000 May 14;1(2):E12. [PubMed:14727845 ]
  2. Galantini L, Leggio C, Konarev PV, Pavel NV: Human serum albumin binding ibuprofen: a 3D description of the unfolding pathway in urea. Biophys Chem. 2010 Apr;147(3):111-22. doi: 10.1016/j.bpc.2010.01.002. Epub 2010 Jan 18. [PubMed:20117876 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
Gene Name:
SLCO2B1
Uniprot ID:
O94956
Molecular Weight:
76709.98 Da
References
  1. Satoh H, Yamashita F, Tsujimoto M, Murakami H, Koyabu N, Ohtani H, Sawada Y: Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos. 2005 Apr;33(4):518-23. Epub 2005 Jan 7. [PubMed:15640378 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. [PubMed:12954186 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Atpase activity, coupled to transmembrane movement of substances
Specific Function:
May be an organic anion pump relevant to cellular detoxification.
Gene Name:
ABCC4
Uniprot ID:
O15439
Molecular Weight:
149525.33 Da
References
  1. Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. [PubMed:12835412 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Gene Name:
ABCC1
Uniprot ID:
P33527
Molecular Weight:
171589.5 Da
References
  1. Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. [PubMed:12835412 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. [PubMed:11883641 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Molecular Weight:
61815.78 Da
References
  1. Mulato AS, Ho ES, Cihlar T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5. [PubMed:10991954 ]
  2. Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. [PubMed:12130730 ]
  3. Uwai Y, Saito H, Inui K: Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter. Eur J Pharmacol. 2000 Dec 1;409(1):31-6. [PubMed:11099697 ]
  4. Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. [PubMed:10220563 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
Gene Name:
SLC22A8
Uniprot ID:
Q8TCC7
Molecular Weight:
59855.585 Da
References
  1. Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. [PubMed:11306713 ]
  2. Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. [PubMed:12130730 ]
  3. Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. [PubMed:15100168 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.
Gene Name:
SLC22A11
Uniprot ID:
Q9NSA0
Molecular Weight:
59970.945 Da
References
  1. Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. [PubMed:12130730 ]
  2. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem. 2000 Feb 11;275(6):4507-12. [PubMed:10660625 ]
Drug created on June 13, 2005 07:24 / Updated on June 24, 2017 09:19