Complicated Urinary Tract Infection

Also known as: Complicated Urinary Tract Infections / Complicated Urinary Tract Infection (cUTI) / CUTI / Complicated Urinary Tract Infections (cUTIs) / Urinary Tract Infection, Complicated / Urinary Tract Infection Complicated / Complicated Urinary Tract Infections (cUTI) / Complicated UTI

DrugDrug NameDrug Description
DB09060AvibactamA non-β-lactam β-lactamase inhibitor used in combination with ceftazidime for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, and hospital or ventilator-acquired pneumonia.
DB01413CefepimeA fourth-generation cephalosporin antibiotic used in the treatment of various bacterial infections caused by susceptible bacteria, such as pneumonia, urinary tract infections, and skin infections.
DB01597CilastatinA renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections.
DB00537CiprofloxacinA second generation fluoroquinolone used to treat various susceptible bacterial infections.
DB06211DoripenemAn antibiotic of the penem class used to treat complicated intra-abdominal and urinary tract infections.
DB00828FosfomycinA broad spectrum antibiotic used to treat uncomplicated urinary tract infections.
DB01598ImipenemA carbapenem antibiotic normally administered with cilastatin to treat a variety of infections.
DB01137LevofloxacinA fluoroquinolone used to treat infections including the upper respiratory tract, skin and skin structure, urinary tract, as well as pneumonia, chronic bacterial prostatitis, post exposure treatment of inhaled anthrax, and the plague.
DB01165OfloxacinAn antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract.
DB12615PlazomicinAn aminoglycoside antibiotic used to treat complicated urinary tract infections.
DB12377RelebactamA beta-lactamase inhibitor used to prevent hydrolysis of beta-lactam antibiotics, leading to increased effectiveness.
DrugDrug NameTargetType
DB09060AvibactamCanalicular multispecific organic anion transporter 1transporter
DB09060AvibactamSolute carrier family 22 member 8transporter
DB09060AvibactamBeta-lactamase TEMtarget
DB09060AvibactamBeta-lactamase CTX-Mtarget
DB09060AvibactamBeta-lactamasetarget
DB09060AvibactamBeta-lactamase SHV-1target
DB09060AvibactamBeta-lactamase SHV-2target
DB09060AvibactamBeta-lactamase SHV-1target
DB09060AvibactamClass D OXA-48 carbapenemasetarget
DB09060AvibactamCarbapenem-hydrolyzing beta-lactamase KPCtarget
DB09060AvibactamBeta-lactamase CTX-M-15target
DB09060AvibactamExtended-spectrum beta-lactamase PER-1target
DB01413CefepimeSolute carrier family 22 member 5transporter
DB01413CefepimeSolute carrier family 15 member 1transporter
DB01413CefepimeSolute carrier family 15 member 2transporter
DB01413CefepimePenicillin-binding protein 2target
DB01413CefepimePeptidoglycan synthase FtsItarget
DB01413CefepimePenicillin-binding protein 3target
DB01413CefepimePenicillin-binding protein 2target
DB01597CilastatinDipeptidase 1target
DB01597CilastatinSolute carrier family 22 member 6transporter
DB01597CilastatinSolute carrier family 22 member 8transporter
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 2-alphatarget
DB00537CiprofloxacinCytochrome P450 1A2enzyme
DB00537CiprofloxacinCytochrome P450 3A4enzyme
DB00537CiprofloxacinCytochrome P450 3A5enzyme
DB00537CiprofloxacinCytochrome P450 3A7enzyme
DB00537CiprofloxacinP-glycoprotein 1transporter
DB00537CiprofloxacinPotassium voltage-gated channel subfamily H member 2target
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Btarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinMultidrug resistance protein MdtKtarget
DB00537CiprofloxacinGyrase Atarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinMultidrug and toxin extrusion protein 1transporter
DB00537CiprofloxacinMultidrug and toxin extrusion protein 2transporter
DB00537CiprofloxacinSerum albumincarrier
DB06211DoripenemDipeptidase 1enzyme
DB06211DoripenemPenicillin-binding protein 1Atarget
DB06211DoripenemPenicillin-binding protein 1Btarget
DB06211DoripenemPenicillin-binding protein 2target
DB06211DoripenemPenicillin-binding protein 3target
DB06211DoripenemPenicillin-binding protein 4target
DB06211DoripenemSolute carrier family 22 member 8transporter
DB00828FosfomycinUDP-N-acetylglucosamine 1-carboxyvinyltransferasetarget
DB01598ImipenemPenicillin-binding protein 1Atarget
DB01598ImipenemPenicillin-binding protein 1Btarget
DB01598ImipenemPenicillin-binding protein 2target
DB01598ImipenemPenicillin-binding protein 3target
DB01598ImipenemDipeptidase 1enzyme
DB01598ImipenemPenicillin-binding protein 4target
DB01598ImipenemBeta-lactamase SHV-1enzyme
DB01598ImipenemBeta-lactamase TEMenzyme
DB01598ImipenemBeta-lactamase CTX-Menzyme
DB01598ImipenemBeta-lactamase (KPC-2)enzyme
DB01137LevofloxacinDNA gyrase subunit Atarget
DB01137LevofloxacinDNA topoisomerase 4 subunit Atarget
DB01137LevofloxacinDNA topoisomerase 2-alphatarget
DB01137LevofloxacinCytochrome P450 1A2enzyme
DB01137LevofloxacinSolute carrier family 22 member 2transporter
DB01137LevofloxacinP-glycoprotein 1transporter
DB01137LevofloxacinSolute carrier family 22 member 4transporter
DB01137LevofloxacinSolute carrier family 22 member 6transporter
DB01137LevofloxacinCytochrome P450 3A4enzyme
DB01137LevofloxacinMultidrug and toxin extrusion protein 1transporter
DB01137LevofloxacinMultidrug and toxin extrusion protein 2transporter
DB01137LevofloxacinCytochrome P450 2C9enzyme
DB01165OfloxacinDNA gyrase subunit Atarget
DB01165OfloxacinDNA topoisomerase 4 subunit Atarget
DB01165OfloxacinDNA topoisomerase 2-alphatarget
DB01165OfloxacinCytochrome P450 1A2enzyme
DB01165OfloxacinSolute carrier family 22 member 5transporter
DB01165OfloxacinMultidrug resistance-associated protein 1transporter
DB01165OfloxacinSolute carrier family 22 member 6transporter
DB01165OfloxacinCanalicular multispecific organic anion transporter 1transporter
DB01165OfloxacinSolute carrier family 22 member 4transporter
DB01165OfloxacinBile salt export pumptransporter
DB12615PlazomicinMultidrug and toxin extrusion protein 1transporter
DB12615PlazomicinMultidrug and toxin extrusion protein 2transporter
DB12615Plazomicin30S ribosomal protein S14target
DB12615Plazomicin30S ribosomal protein S11target
DB12377RelebactamSolute carrier family 22 member 8transporter
DB12377RelebactamSolute carrier family 22 member 11transporter
DB12377RelebactamMultidrug and toxin extrusion protein 1transporter
DB12377RelebactamMultidrug and toxin extrusion protein 2transporter
DB12377RelebactamBeta-lactamase TEMtarget
DB12377RelebactamBeta-lactamase SHV-1target
DB12377RelebactamBeta-lactamase CTX-Mtarget
DB12377RelebactamBeta-lactamase (KPC-2)target
DB12377RelebactamBeta-lactamasetarget
DrugDrug NamePhaseStatusCount
DB09060Avibactam2Completed2
DB01413Cefepime2Completed1
DB00438Ceftazidime2Completed3
DB09050Ceftolozane2Completed1
DB09050Ceftolozane2Recruiting1
DB01597Cilastatin2Completed2
DB01598Imipenem2Completed2
DB01137Levofloxacin2Completed1
DB00760Meropenem2Recruiting1
DB12615Plazomicin2Completed1
DB09324Sulbactam2Completed1
DB01606Tazobactam2Recruiting1
DB00828Fosfomycin2 / 3Completed1
DB00319Piperacillin2 / 3Completed1
DB01606Tazobactam2 / 3Completed1
DB01060Amoxicillin3Active Not Recruiting1
DB09060Avibactam3Completed1
DB14879Cefiderocol3Active Not Recruiting1
DB00438Ceftazidime3Completed1
DB09050Ceftolozane3Completed1
DB01212Ceftriaxone3Completed1
DB01597Cilastatin3Completed1
DB00537Ciprofloxacin3Active Not Recruiting1
DB00537Ciprofloxacin3Not Yet Recruiting1
DB00766Clavulanic acid3Active Not Recruiting1
DB12329Eravacycline3Completed2
DB00303Ertapenem3Active Not Recruiting1
DB00303Ertapenem3Completed1
DB00303Ertapenem3Recruiting1
DB01598Imipenem3Completed1
DB01137Levofloxacin3Completed5
DB00760Meropenem3Completed4
DB00760Meropenem3Not Yet Recruiting1
DB00916Metronidazole3Completed1
DB00319Piperacillin3Completed1
DB12615Plazomicin3Completed1
DB01032Probenecid3Active Not Recruiting1
DB12377Relebactam3Completed1
DB09324Sulbactam3Completed1
DB15284Sulopenem3Active Not Recruiting1
DB01606Tazobactam3Completed2
DB12107Vaborbactam3Completed2
DB00802AlfentanilNot AvailableRecruiting1
DB00479AmikacinNot AvailableRecruiting1
DB00513Aminocaproic acidNot AvailableRecruiting1
DB00559BosentanNot AvailableRecruiting1
DB01413CefepimeNot AvailableRecruiting1
DB00369CidofovirNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableRecruiting1
DB00363ClozapineNot AvailableRecruiting1
DB00828FosfomycinNot AvailableRecruiting1
DB00502HaloperidolNot AvailableRecruiting1
DB00598LabetalolNot AvailableRecruiting1
DB08815LurasidoneNot AvailableRecruiting1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB01618MolindoneNot AvailableRecruiting1
DB00607NafcillinNot AvailableRecruiting1
DB01115NifedipineNot AvailableRecruiting1
DB00497OxycodoneNot AvailableRecruiting1
DB00312PentobarbitalNot AvailableRecruiting1
DB00319PiperacillinNot AvailableRecruiting1
DB00728RocuroniumNot AvailableRecruiting1
DB00658SevelamerNot AvailableRecruiting1
DB00421SpironolactoneNot AvailableRecruiting1
DB01606TazobactamNot AvailableRecruiting1
DB00684TobramycinNot AvailableRecruiting1
DB00302Tranexamic acidNot AvailableRecruiting1
DB00512VancomycinNot AvailableRecruiting1
DB01339VecuroniumNot AvailableRecruiting1
DB00682WarfarinNot AvailableRecruiting1
DB00246ZiprasidoneNot AvailableRecruiting1
DB00425ZolpidemNot AvailableRecruiting1