Plazomicin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Plazomicin
Accession Number
DB12615
Type
Small Molecule
Groups
Investigational
Description

Plazomicin has been used in trials studying the treatment of Acute Pyelonephritis, Complicated Urinary Tract Infection, Acute Pyelonephritis (AP) Due to CRE, Bloodstream Infections (BSI) Due to CRE, and Complicated Urinary Tract Infection (cUTI) Due to CRE, among others.

Structure
Thumb
Synonyms
Not Available
Categories
UNII
LYO9XZ250J
CAS number
1154757-24-0
Weight
Average: 592.691
Monoisotopic: 592.34319177
Chemical Formula
C25H48N6O10
InChI Key
IYDYFVUFSPQPPV-PEXOCOHZSA-N
InChI
InChI=1S/C25H48N6O10/c1-25(37)11-38-24(18(35)21(25)29-2)41-20-15(31-22(36)16(33)5-6-26)9-14(28)19(17(20)34)40-23-13(27)4-3-12(39-23)10-30-7-8-32/h3,13-21,23-24,29-30,32-35,37H,4-11,26-28H2,1-2H3,(H,31,36)/t13-,14+,15-,16+,17+,18-,19-,20+,21-,23-,24-,25+/m1/s1
IUPAC Name
(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-{[(2S,3R)-3-amino-6-{[(2-hydroxyethyl)amino]methyl}-3,4-dihydro-2H-pyran-2-yl]oxy}-2-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide
SMILES

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AceclofenacAceclofenac may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
AcemetacinAcemetacin may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Experimental, Investigational
AcetyldigitoxinThe serum concentration of Acetyldigitoxin can be decreased when it is combined with Plazomicin.Approved
AcetyldigoxinThe serum concentration of Acetyldigoxin can be decreased when it is combined with Plazomicin.Experimental
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Vet Approved
AdapaleneAdapalene may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
AlclofenacAlclofenac may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Withdrawn
AlcuroniumPlazomicin may increase the respiratory depressant activities of Alcuronium.Experimental
Alendronic acidPlazomicin may increase the hypocalcemic activities of Alendronic acid.Approved
AlminoprofenAlminoprofen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
AmdinocillinThe serum concentration of Plazomicin can be decreased when it is combined with Amdinocillin.Investigational, Withdrawn
AmoxicillinThe serum concentration of Plazomicin can be decreased when it is combined with Amoxicillin.Approved, Vet Approved
Amphotericin BAmphotericin B may increase the nephrotoxic activities of Plazomicin.Approved, Investigational
AmpicillinThe serum concentration of Plazomicin can be decreased when it is combined with Ampicillin.Approved, Vet Approved
AndrographolideAndrographolide may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
AnisodamineAnisodamine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
AntipyrineAntipyrine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
ApocyninApocynin may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
ApremilastApremilast may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
AspoxicillinThe serum concentration of Plazomicin can be decreased when it is combined with Aspoxicillin.Experimental
AtracuriumPlazomicin may increase the respiratory depressant activities of Atracurium.Experimental, Investigational
Atracurium besylatePlazomicin may increase the respiratory depressant activities of Atracurium besylate.Approved
AzapropazoneAzapropazone may decrease the excretion rate of Plazomicin which could result in a higher serum level.Withdrawn
AzelastineAzelastine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
AzidocillinThe serum concentration of Plazomicin can be decreased when it is combined with Azidocillin.Approved
AzlocillinThe serum concentration of Plazomicin can be decreased when it is combined with Azlocillin.Approved
BacampicillinThe serum concentration of Plazomicin can be decreased when it is combined with Bacampicillin.Approved, Investigational
BalsalazideBalsalazide may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
BendazacBendazac may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
BenorilateBenorilate may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
BenoxaprofenBenoxaprofen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Withdrawn
Benzathine benzylpenicillinThe serum concentration of Plazomicin can be decreased when it is combined with Benzathine benzylpenicillin.Approved, Vet Approved
BenzydamineBenzydamine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
BenzylpenicillinThe serum concentration of Plazomicin can be decreased when it is combined with Benzylpenicillin.Approved, Vet Approved
Benzylpenicilloyl PolylysineThe serum concentration of Plazomicin can be decreased when it is combined with Benzylpenicilloyl Polylysine.Approved
BevoniumBevonium may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
Botulinum Toxin Type APlazomicin may increase the neuromuscular blocking activities of Botulinum Toxin Type A.Approved, Investigational
Botulinum Toxin Type BPlazomicin may increase the neuromuscular blocking activities of Botulinum Toxin Type B.Approved
BromfenacBromfenac may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
BucillamineBucillamine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
BufexamacBufexamac may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
BumadizoneBumadizone may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
BumetanideThe risk or severity of adverse effects can be increased when Bumetanide is combined with Plazomicin.Approved
CapreomycinCapreomycin may increase the neuromuscular blocking activities of Plazomicin.Approved
CarbenicillinThe serum concentration of Plazomicin can be decreased when it is combined with Carbenicillin.Approved, Investigational
Carbenicillin indanylThe serum concentration of Plazomicin can be decreased when it is combined with Carbenicillin indanyl.Approved, Investigational
CarboplatinPlazomicin may increase the ototoxic activities of Carboplatin.Approved
CarfecillinThe serum concentration of Plazomicin can be decreased when it is combined with Carfecillin.Experimental
CarprofenCarprofen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
CelecoxibCelecoxib may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
ChloroquineChloroquine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Vet Approved
Choline magnesium trisalicylateCholine magnesium trisalicylate may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
CisatracuriumPlazomicin may increase the respiratory depressant activities of Cisatracurium.Approved, Experimental
Cisatracurium besylatePlazomicin may increase the respiratory depressant activities of Cisatracurium besylate.Approved
CisplatinCisplatin may increase the nephrotoxic activities of Plazomicin.Approved
Clodronic AcidPlazomicin may increase the hypocalcemic activities of Clodronic Acid.Approved, Investigational, Vet Approved
ClonixinClonixin may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
CloxacillinThe serum concentration of Plazomicin can be decreased when it is combined with Cloxacillin.Approved, Vet Approved
ColistimethatePlazomicin may increase the nephrotoxic activities of Colistimethate.Approved, Vet Approved
CurcuminCurcumin may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
CyclacillinThe serum concentration of Plazomicin can be decreased when it is combined with Cyclacillin.Approved
CyclosporinePlazomicin may increase the nephrotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
CymarinThe serum concentration of Cymarin can be decreased when it is combined with Plazomicin.Experimental
D-LimoneneD-Limonene may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
DecamethoniumPlazomicin may increase the respiratory depressant activities of Decamethonium.Approved
DeslanosideThe serum concentration of Deslanoside can be decreased when it is combined with Plazomicin.Approved
DiclofenacDiclofenac may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Vet Approved
DicloxacillinThe serum concentration of Plazomicin can be decreased when it is combined with Dicloxacillin.Approved, Vet Approved
DifenpiramideDifenpiramide may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
DiflunisalDiflunisal may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Plazomicin.Approved, Investigational
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Plazomicin.Approved
Digoxin Immune Fab (Ovine)The serum concentration of Digoxin Immune Fab (Ovine) can be decreased when it is combined with Plazomicin.Approved
Domoic AcidPlazomicin may increase the respiratory depressant activities of Domoic Acid.Experimental
Doxacurium chloridePlazomicin may increase the respiratory depressant activities of Doxacurium chloride.Approved
DroxicamDroxicam may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
DuvelisibDuvelisib may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
E-6201E-6201 may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
EpicillinThe serum concentration of Plazomicin can be decreased when it is combined with Epicillin.Experimental
EpirizoleEpirizole may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Etacrynic acid is combined with Plazomicin.Approved
EtanerceptEtanercept may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
EthenzamideEthenzamide may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
Etidronic acidPlazomicin may increase the hypocalcemic activities of Etidronic acid.Approved
EtodolacEtodolac may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
EtoricoxibEtoricoxib may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
Evening primrose oilEvening primrose oil may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
exisulindexisulind may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
FelbinacFelbinac may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
FenbufenFenbufen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
FenoprofenFenoprofen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
FentiazacFentiazac may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
FeprazoneFeprazone may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
Ferulic acidFerulic acid may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
FloctafenineFloctafenine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Withdrawn
FlucloxacillinThe serum concentration of Plazomicin can be decreased when it is combined with Flucloxacillin.Approved, Investigational
FlunixinFlunixin may decrease the excretion rate of Plazomicin which could result in a higher serum level.Vet Approved
FlunoxaprofenFlunoxaprofen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
FlurbiprofenFlurbiprofen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
FoscarnetFoscarnet may increase the nephrotoxic activities of Plazomicin.Approved
FurosemideThe risk or severity of adverse effects can be increased when Furosemide is combined with Plazomicin.Approved, Vet Approved
GallaminePlazomicin may increase the respiratory depressant activities of Gallamine.Experimental
Gallamine TriethiodidePlazomicin may increase the respiratory depressant activities of Gallamine Triethiodide.Approved
GitoformateThe serum concentration of Gitoformate can be decreased when it is combined with Plazomicin.Experimental
GuacetisalGuacetisal may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
HigenamineHigenamine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
IbandronatePlazomicin may increase the hypocalcemic activities of Ibandronate.Approved, Investigational
IbuprofenIbuprofen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
IbuproxamIbuproxam may decrease the excretion rate of Plazomicin which could result in a higher serum level.Withdrawn
IcatibantIcatibant may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
Imidazole salicylateImidazole salicylate may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
IndobufenIndobufen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
IndomethacinIndomethacin may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
IndoprofenIndoprofen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Withdrawn
IsoxicamIsoxicam may decrease the excretion rate of Plazomicin which could result in a higher serum level.Withdrawn
KebuzoneKebuzone may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
KetoprofenKetoprofen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Vet Approved
KetorolacKetorolac may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
Lanatoside CThe serum concentration of Lanatoside C can be decreased when it is combined with Plazomicin.Experimental
LeflunomideLeflunomide may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
LisofyllineLisofylline may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
LonazolacLonazolac may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
LornoxicamLornoxicam may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
LoxoprofenLoxoprofen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
LumiracoxibLumiracoxib may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
Magnesium salicylateMagnesium salicylate may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
MannitolMannitol may increase the nephrotoxic activities of Plazomicin.Approved, Investigational
MasoprocolMasoprocol may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
MecamylaminePlazomicin may increase the neuromuscular blocking activities of Mecamylamine.Approved
Meclofenamic acidMeclofenamic acid may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Vet Approved
Mefenamic acidMefenamic acid may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
MeloxicamMeloxicam may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Vet Approved
MesalazineMesalazine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
MetamizoleMetamizole may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational, Withdrawn
MetampicillinThe serum concentration of Plazomicin can be decreased when it is combined with Metampicillin.Experimental
MeticillinThe serum concentration of Plazomicin can be decreased when it is combined with Meticillin.Approved, Investigational
MetildigoxinThe serum concentration of Metildigoxin can be decreased when it is combined with Plazomicin.Experimental
MetocurinePlazomicin may increase the respiratory depressant activities of Metocurine.Approved
Metocurine IodidePlazomicin may increase the respiratory depressant activities of Metocurine Iodide.Withdrawn
MezlocillinThe serum concentration of Plazomicin can be decreased when it is combined with Mezlocillin.Approved, Investigational
MivacuriumPlazomicin may increase the respiratory depressant activities of Mivacurium.Approved
MizoribineMizoribine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
MofebutazoneMofebutazone may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
Mycophenolate mofetilMycophenolate mofetil may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
Mycophenolic acidMycophenolic acid may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
NabumetoneNabumetone may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
NafamostatNafamostat may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
NafcillinThe serum concentration of Plazomicin can be decreased when it is combined with Nafcillin.Approved
NaftifineNaftifine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
NaproxenNaproxen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Vet Approved
NeosaxitoxinPlazomicin may increase the respiratory depressant activities of Neosaxitoxin.Investigational
NepafenacNepafenac may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
NifenazoneNifenazone may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
Niflumic AcidNiflumic Acid may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
NimesulideNimesulide may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational, Withdrawn
NitroaspirinNitroaspirin may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
OleandrinThe serum concentration of Oleandrin can be decreased when it is combined with Plazomicin.Experimental, Investigational
OlopatadineOlopatadine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
OlsalazineOlsalazine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
OrgoteinOrgotein may decrease the excretion rate of Plazomicin which could result in a higher serum level.Vet Approved
OuabainThe serum concentration of Ouabain can be decreased when it is combined with Plazomicin.Approved
OxacillinThe serum concentration of Plazomicin can be decreased when it is combined with Oxacillin.Approved
OxaprozinOxaprozin may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
OxyphenbutazoneOxyphenbutazone may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Withdrawn
PamidronatePlazomicin may increase the hypocalcemic activities of Pamidronate.Approved
PancuroniumPlazomicin may increase the respiratory depressant activities of Pancuronium.Approved
ParecoxibParecoxib may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
ParthenolideParthenolide may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
PenamecillinThe serum concentration of Plazomicin can be decreased when it is combined with Penamecillin.Experimental
PenimepicyclineThe serum concentration of Plazomicin can be decreased when it is combined with Penimepicycline.Experimental
PeruvosideThe serum concentration of Peruvoside can be decreased when it is combined with Plazomicin.Experimental
PhenoxymethylpenicillinThe serum concentration of Plazomicin can be decreased when it is combined with Phenoxymethylpenicillin.Approved, Vet Approved
PhenylbutazonePhenylbutazone may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Vet Approved
PimecrolimusPimecrolimus may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
PipecuroniumPlazomicin may increase the respiratory depressant activities of Pipecuronium.Approved
PiperacillinThe serum concentration of Plazomicin can be decreased when it is combined with Piperacillin.Approved
PiretanideThe risk or severity of adverse effects can be increased when Piretanide is combined with Plazomicin.Experimental
PirfenidonePirfenidone may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
PiroxicamPiroxicam may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
PirprofenPirprofen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
PivampicillinThe serum concentration of Plazomicin can be decreased when it is combined with Pivampicillin.Approved
PivmecillinamThe serum concentration of Plazomicin can be decreased when it is combined with Pivmecillinam.Approved
PranoprofenPranoprofen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental, Investigational
Procaine benzylpenicillinThe serum concentration of Plazomicin can be decreased when it is combined with Procaine benzylpenicillin.Approved, Vet Approved
ProglumetacinProglumetacin may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
PropacetamolPropacetamol may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
PropicillinThe serum concentration of Plazomicin can be decreased when it is combined with Propicillin.Experimental
PropyphenazonePropyphenazone may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
ProquazoneProquazone may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
ProscillaridinThe serum concentration of Proscillaridin can be decreased when it is combined with Plazomicin.Experimental
PTC299PTC299 may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
PyrantelPlazomicin may increase the respiratory depressant activities of Pyrantel.Approved, Vet Approved
RapacuroniumPlazomicin may increase the respiratory depressant activities of Rapacuronium.Withdrawn
ResveratrolResveratrol may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Experimental, Investigational
RisedronatePlazomicin may increase the hypocalcemic activities of Risedronate.Approved, Investigational
RocuroniumPlazomicin may increase the respiratory depressant activities of Rocuronium.Approved
RofecoxibRofecoxib may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational, Withdrawn
SalicylamideSalicylamide may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
Salicylic acidSalicylic acid may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Vet Approved
SalsalateSalsalate may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
SemapimodSemapimod may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
SeratrodastSeratrodast may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
SerrapeptaseSerrapeptase may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
SRT501SRT501 may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
SuccinylcholinePlazomicin may increase the respiratory depressant activities of Succinylcholine.Approved
SulbactamThe serum concentration of Plazomicin can be decreased when it is combined with Sulbactam.Approved
SulbenicillinThe serum concentration of Plazomicin can be decreased when it is combined with Sulbenicillin.Experimental
SulfasalazineSulfasalazine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
SulindacSulindac may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
SultamicillinThe serum concentration of Plazomicin can be decreased when it is combined with Sultamicillin.Investigational
SuprofenSuprofen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Withdrawn
SuxibuzoneSuxibuzone may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
TalampicillinThe serum concentration of Plazomicin can be decreased when it is combined with Talampicillin.Experimental
TarenflurbilTarenflurbil may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
TazobactamThe serum concentration of Plazomicin can be decreased when it is combined with Tazobactam.Approved
Technetium Tc-99m etidronatePlazomicin may increase the hypocalcemic activities of Technetium Tc-99m etidronate.Approved
Technetium Tc-99m medronatePlazomicin may increase the hypocalcemic activities of Technetium Tc-99m medronate.Approved
TenidapTenidap may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
Tenofovir disoproxilThe serum concentration of Plazomicin can be increased when it is combined with Tenofovir disoproxil.Approved, Investigational
TenoxicamTenoxicam may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
TepoxalinTepoxalin may decrease the excretion rate of Plazomicin which could result in a higher serum level.Vet Approved
TeriflunomideTeriflunomide may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
Tiaprofenic acidTiaprofenic acid may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
TicarcillinThe serum concentration of Plazomicin can be decreased when it is combined with Ticarcillin.Approved, Investigational, Vet Approved
Tiludronic acidPlazomicin may increase the hypocalcemic activities of Tiludronic acid.Approved, Investigational, Vet Approved
TinoridineTinoridine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
Tolfenamic AcidTolfenamic Acid may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
TolmetinTolmetin may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved
TorasemideThe risk or severity of adverse effects can be increased when Torasemide is combined with Plazomicin.Approved
TranilastTranilast may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
TribenosideTribenoside may decrease the excretion rate of Plazomicin which could result in a higher serum level.Experimental
TriptolideTriptolide may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
TubocurarinePlazomicin may increase the respiratory depressant activities of Tubocurarine.Approved
ValdecoxibValdecoxib may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational, Withdrawn
VancomycinVancomycin may increase the nephrotoxic activities of Plazomicin.Approved
VecuroniumPlazomicin may increase the respiratory depressant activities of Vecuronium.Approved
ZaltoprofenZaltoprofen may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational
ZileutonZileuton may decrease the excretion rate of Plazomicin which could result in a higher serum level.Approved, Investigational, Withdrawn
Zoledronic acidPlazomicin may increase the hypocalcemic activities of Zoledronic acid.Approved
ZomepiracZomepirac may decrease the excretion rate of Plazomicin which could result in a higher serum level.Withdrawn
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
42613186
PubChem Substance
347828829
ChemSpider
26390008
ChEMBL
CHEMBL1650559

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentHealthy Volunteers1
2CompletedTreatmentAcute Pyelonephritis / Complicated Urinary Tract Infections1
3CompletedTreatmentAcute Pyelonephritis (AP) Due to CRE / Bloodstream Infections (BSI) Due to CRE / Complicated Urinary Tract Infection (cUTI) Due to CRE / Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE / Ventilator-Associated Bacterial Pneumonia (VABP) Due to CRE1
3CompletedTreatmentAcute Pyelonephritis / Complicated Urinary Tract Infections1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility12.3 mg/mLALOGPS
logP-2.2ALOGPS
logP-6.1ChemAxon
logS-1.7ALOGPS
pKa (Strongest Acidic)12.48ChemAxon
pKa (Strongest Basic)9.89ChemAxon
Physiological Charge5ChemAxon
Hydrogen Acceptor Count15ChemAxon
Hydrogen Donor Count11ChemAxon
Polar Surface Area269.29 Å2ChemAxon
Rotatable Bond Count13ChemAxon
Refractivity145.09 m3·mol-1ChemAxon
Polarizability62.27 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as gamma amino acids and derivatives. These are amino acids having a (-NH2) group attached to the gamma carbon atom.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Gamma amino acids and derivatives
Alternative Parents
O-glycosyl compounds / Aminocyclitols and derivatives / Aminosaccharides / Cyclohexylamines / Cyclohexanols / Oxanes / N-acyl amines / Monosaccharides / Tertiary alcohols / 1,3-aminoalcohols
show 11 more
Substituents
Gamma amino acid or derivatives / Glycosyl compound / O-glycosyl compound / Aminocyclitol or derivatives / Cyclohexanol / Cyclohexylamine / Amino saccharide / Cyclitol or derivatives / Fatty amide / Fatty acyl
show 30 more
Molecular Framework
Aliphatic heteromonocyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 17:13 / Updated on December 01, 2017 16:31