Metastatic Bladder Cancer

Also known as: Bladder cancer stage IV / Stage IV Bladder Cancer / Carcinoma urinary bladder stage IV / Urinary bladder carcinoma stage IV / Metastatic carcinoma of the bladder / Bladder carcinoma stage IV / Ca bladder stage IV / Carcinoma bladder stage IV

DrugDrug NameDrug Description
DB01248DocetaxelDocetaxel is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel binds to microtubules reversibly with high affinity and has a maximum stoichiometry of one mole docetaxel per mole tubulin in microtubules.
DB00441GemcitabineGemcitabine is a nucleoside analog used as chemotherapy. It is marketed as Gemzar® by Eli Lilly and Company. As with fluorouracil and other analogues of pyrimidines, the drug replaces one of the building blocks of nucleic acids, in this case cytidine, during DNA replication. The process arrests tumor growth, as new nucleosides cannot be attached to the "faulty" nucleoside, resulting in apoptosis (cellular "suicide"). Gemcitabine is used in various carcinomas: non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. It is being investigated for use in oesophageal cancer, and is used experimentally in lymphomas and various other tumor types.
DB01229PaclitaxelPaclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a US National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it taxol. Later it was discovered that endophytic fungi in the bark synthesize paclitaxel. When it was developed commercially by Bristol-Myers Squibb (BMS), the generic name was changed to paclitaxel and the BMS compound is sold under the trademark Taxol. In this formulation, paclitaxel is dissolved in Kolliphor EL and ethanol, as a delivery agent. A newer formulation, in which paclitaxel is bound to albumin, is sold under the trademark Abraxane. [Wikipedia]
DrugDrug NameTargetType
DB01248DocetaxelApoptosis regulator Bcl-2target
DB01248DocetaxelTubulin beta-1 chaintarget
DB01248DocetaxelCytochrome P450 3A4enzyme
DB01248DocetaxelCytochrome P450 3A5enzyme
DB01248DocetaxelCytochrome P450 3A7enzyme
DB01248DocetaxelMultidrug resistance protein 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 7transporter
DB01248DocetaxelCytochrome P450 1B1enzyme
DB01248DocetaxelMicrotubule-associated protein 2target
DB01248DocetaxelMicrotubule-associated protein 4target
DB01248DocetaxelMicrotubule-associated protein tautarget
DB01248DocetaxelSolute carrier organic anion transporter family member 1B3transporter
DB01248DocetaxelSolute carrier family 22 member 7transporter
DB01248DocetaxelATP-binding cassette sub-family G member 2transporter
DB01248DocetaxelCanalicular multispecific organic anion transporter 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 1transporter
DB01248DocetaxelNuclear receptor subfamily 1 group I member 2target
DB00441GemcitabineRibonucleoside-diphosphate reductase large subunittarget
DB00441GemcitabineUMP-CMP kinasetarget
DB00441GemcitabineThymidylate synthasetarget
DB00441GemcitabineCytidine deaminaseenzyme
DB00441GemcitabineDeoxycytidine kinaseenzyme
DB00441GemcitabineMultidrug resistance protein 1transporter
DB00441GemcitabineMultidrug resistance-associated protein 7transporter
DB00441GemcitabineEquilibrative nucleoside transporter 1transporter
DB00441GemcitabineDNAtarget
DB00441GemcitabineSodium/nucleoside cotransporter 1transporter
DB00441GemcitabineEquilibrative nucleoside transporter 2transporter
DB00441GemcitabineSolute carrier family 28 member 3transporter
DB01229PaclitaxelCytochrome P450 2C8enzyme
DB01229PaclitaxelCytochrome P450 3A4enzyme
DB01229PaclitaxelCytochrome P450 3A5enzyme
DB01229PaclitaxelCytochrome P450 3A7enzyme
DB01229PaclitaxelCytochrome P450 2C9enzyme
DB01229PaclitaxelCytochrome P450 19A1enzyme
DB01229PaclitaxelCytochrome P450 1B1enzyme
DB01229PaclitaxelApoptosis regulator Bcl-2target
DB01229PaclitaxelTubulin beta-1 chaintarget
DB01229PaclitaxelNuclear receptor subfamily 1 group I member 2target
DB01229PaclitaxelMicrotubule-associated protein 4target
DB01229PaclitaxelMicrotubule-associated protein 2target
DB01229PaclitaxelMicrotubule-associated protein tautarget
DB01229PaclitaxelBile salt export pumptransporter
DB01229PaclitaxelMultidrug resistance protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 7transporter
DB01229PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
DB01229PaclitaxelATP-binding cassette sub-family G member 2transporter
DB01229PaclitaxelCanalicular multispecific organic anion transporter 1transporter
DrugDrug NamePhaseStatusCount
DB04940Eribulin0Active Not Recruiting1
DB08871Eribulin0Active Not Recruiting1
DB00958Carboplatin1Completed1
DB00515Cisplatin1Terminated1
DB01262Decitabine1Completed1
DB00530Erlotinib1Completed1
DB00441Gemcitabine1Terminated1
DB05322INGN 2011Completed1
DB12117Mitometh1Terminated1
DB01229Paclitaxel1Completed1
DB00072Trastuzumab1Completed1
DB07232Veliparib1Terminated1
DB11595Atezolizumab1 / 2Recruiting1
DB11945Avelumab1 / 2Recruiting1
DB00515Cisplatin1 / 2Completed1
DB00515Cisplatin1 / 2Recruiting1
DB08871Eribulin1 / 2Active Not Recruiting1
DB00441Gemcitabine1 / 2Completed1
DB00441Gemcitabine1 / 2Recruiting1
DB12257Platinum1 / 2Completed1
DB00877Sirolimus1 / 2Completed1
DB08916Afatinib2Recruiting1
DB06094Apatorsen2Completed1
DB00188Bortezomib2Completed1
DB00958Carboplatin2Completed3
DB00515Cisplatin2Completed2
DB01248Docetaxel2Terminated1
DB00997Doxorubicin2Completed1
DB11714Durvalumab2Recruiting1
DB00441Gemcitabine2Completed4
DB04845Ixabepilone2Completed1
DB01259Lapatinib2Terminated1
DB09035Nivolumab2Recruiting1
DB01229Paclitaxel2Completed2
DB06589Pazopanib2Completed1
DB00019Pegfilgrastim2Completed1
DB09037Pembrolizumab2Recruiting1
DB12257Platinum2Completed1
DB00398Sorafenib2Completed1
DB00398Sorafenib2Terminated1
DB00072Trastuzumab2Completed2
DB00072Trastuzumab2Terminated1
DB00112Bevacizumab3Active Not Recruiting1
DB00515Cisplatin3Active Not Recruiting1
DB00515Cisplatin3Completed1
DB00997Doxorubicin3Completed1
DB00099Filgrastim3Completed1
DB00441Gemcitabine3Active Not Recruiting1
DB00441Gemcitabine3Completed1
DB00563Methotrexate3Completed1
DB12117Mitometh3Completed1
DB12257Platinum3Active Not Recruiting1
DB00570Vinblastine3Completed1