Identification

Name
Docetaxel
Accession Number
DB01248  (APRD00932)
Type
Small Molecule
Groups
Approved, Investigational
Description

Docetaxel is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel binds to microtubules reversibly with high affinity and has a maximum stoichiometry of one mole docetaxel per mole tubulin in microtubules.

Structure
Thumb
Synonyms
  • Docetaxel anhydrous
  • N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel
  • N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
  • TXL
External IDs
CKD-810 / RP-6976
Product Ingredients
IngredientUNIICASInChI Key
Docetaxel trihydrate15H5577CQD148408-66-6XCDIRYDKECHIPE-QHEQPUDQSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DocefrezKit80 mg/4mLSun Pharma Global FZE2011-05-032011-08-10Us
DocefrezKit20 mg/0.8mLSun Pharma Global FZE2011-05-032016-12-31Us
DocetaxelInjection, solution20 mg/1mLIntravenousHospira, Inc.2016-08-24Not applicableUs
DocetaxelKit40 mg/1mLAccord Healthcare Limited2011-06-302018-06-18Us
DocetaxelInjection, solution20 mg/1mLIntravenousHospira, Inc.2016-06-282016-05-03Us
DocetaxelInjection, solution10 mg/1mLIntravenousBaxter Laboratories2018-02-19Not applicableUs
DocetaxelInjection, solution, concentrate200 mg/20mLIntravenousPfizer Laboratories Div Pfizer Inc.2014-06-232017-04-30Us
DocetaxelInjection, solution, concentrate20 mg/1mLIntravenousActavis Pharma Company2014-09-01Not applicableUs
DocetaxelInjection, solution10 mg/1mLIntravenousHospira, Inc.2011-03-17Not applicableUs
DocetaxelInjection, solution, concentrate20 mg/1mLIntravenousAccord Healthcare Limited2012-07-01Not applicableUs
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DocetaxelInjection, solution, concentrate80 mg/4mLIntravenousJiangsu Hengrui Medicine Co., Ltd.2017-08-09Not applicableUs
DocetaxelInjection20 mg/1mLIntravenousAmneal Biosciences Llc2018-01-19Not applicableUs
DocetaxelInjection, solution, concentrate20 mg/1mLIntravenousX Gen Pharmaceuticals, Inc.2017-04-17Not applicableUs
DocetaxelInjection, solution20 mg/1mLIntravenousDr Reddy's Laboratories2017-08-22Not applicableUs
DocetaxelInjection, solution10 mg/1mLIntravenousIngenus Pharmaceuticals Llc2017-09-07Not applicableUs
DocetaxelInjection, solution, concentrate20 mg/1mLIntravenousWinthrop U.S.2010-10-21Not applicableUs
DocetaxelInjection, solution, concentrate40 mg/1mLIntravenousJiangsu Hengrui Medicine Co., Ltd.2017-02-15Not applicableUs
DocetaxelInjection160 mg/8mLIntravenousAmneal Biosciences Llc2018-01-19Not applicableUs
DocetaxelInjection, solution20 mg/1mLIntravenousDr Reddy's Laboratories2014-11-10Not applicableUs
DocetaxelInjection, solution, concentrate20 mg/1mLIntravenousJiangsu Hengrui Medicine Co., Ltd.2017-08-09Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Docetaxel MylanDocetaxel (20 mg/1ml)Injection, solution, concentrateIntravenousMylan S.A.S.2012-01-312015-06-29Eu
Docetaxel MylanDocetaxel (80 mg/4ml)Injection, solution, concentrateIntravenousMylan S.A.S.2012-01-312015-06-29Eu
Docetaxel MylanDocetaxel (20 mg/1ml)Injection, solution, concentrateIntravenousMylan S.A.S.2012-01-312015-06-29Eu
Docetaxel MylanDocetaxel (200 mg/10ml)Injection, solution, concentrateIntravenousMylan S.A.S.2012-01-312015-06-29Eu
Docetaxel MylanDocetaxel (80 mg/4ml)Injection, solution, concentrateIntravenousMylan S.A.S.2012-01-312015-06-29Eu
Docetaxel MylanDocetaxel (200 mg/10ml)Injection, solution, concentrateIntravenousMylan S.A.S.2012-01-312015-06-29Eu
Docetaxel Teva PharmaDocetaxel (20 mg)Injection, solution, concentrateIntravenousTeva Pharma B.V.2011-01-212014-01-21Eu
Docetaxel Teva PharmaDocetaxel (80 mg)Injection, solution, concentrateIntravenousTeva Pharma B.V.2011-01-212014-01-21Eu
Categories
UNII
699121PHCA
CAS number
114977-28-5
Weight
Average: 807.8792
Monoisotopic: 807.346605409
Chemical Formula
C43H53NO14
InChI Key
ZDZOTLJHXYCWBA-VCVYQWHSSA-N
InChI
InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
IUPAC Name
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-15-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1,9,12-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0³,¹⁰.0⁴,⁷]heptadec-13-en-2-yl benzoate
SMILES
[H][C@@]12C[C@H](O)[C@@]3(C)C(=O)[C@H](O)C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C5=CC=CC=C5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C1=CC=CC=C1

Pharmacology

Indication

For the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Also used as a single agent in the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior platinum-based chemotherapy. It is also used in combination with prednisone, in the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer. Furthermore, docetaxel has uses in the treatment of gastric adenocarinoma and head and neck cancer.

Associated Conditions
Pharmacodynamics

Docetaxel is a taxoid antineoplastic agent. It promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, docetaxel induces abnormal arrays or "bundles" of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis.

Mechanism of action

Docetaxel interferes with the normal function of microtubule growth. Whereas drugs like colchicine cause the depolymerization of microtubules in vivo, docetaxel arrests their function by having the opposite effect; it hyper-stabilizes their structure. This destroys the cell's ability to use its cytoskeleton in a flexible manner. Specifically, docetaxel binds to the β-subunit of tubulin. Tubulin is the "building block" of mictotubules, and the binding of docetaxel locks these building blocks in place. The resulting microtubule/docetaxel complex does not have the ability to disassemble. This adversely affects cell function because the shortening and lengthening of microtubules (termed dynamic instability) is necessary for their function as a transportation highway for the cell. Chromosomes, for example, rely upon this property of microtubules during mitosis. Further research has indicated that docetaxel induces programmed cell death (apoptosis) in cancer cells by binding to an apoptosis stopping protein called Bcl-2 (B-cell leukemia 2) and thus arresting its function.

TargetActionsOrganism
ATubulin beta-1 chainNot AvailableHuman
UApoptosis regulator Bcl-2Not AvailableHuman
AMicrotubule-associated protein 2Not AvailableHuman
AMicrotubule-associated protein 4Not AvailableHuman
AMicrotubule-associated protein tauNot AvailableHuman
UNuclear receptor subfamily 1 group I member 2
binder
Human
Absorption

The pharmacokinetic profile is consistent with a three-compartment model. The area under the curve (AUC) was dose proportional following doses of 70 mg/m2 to 115 mg/m2 with infusion times of 1 to 2 hours.

Volume of distribution

The initial rapid decline represents distribution to the peripheral compartments and the late (terminal) phase is due, in part, to a relatively slow efflux of docetaxel from the peripheral compartment. * 113 L

Protein binding

In vitro studies show that 94% protein bound, mainly to a1-acid glycoprotein, albumin, and lipoproteins. When measured in cancer patients, docetaxel is 97% bound to plasma protein. Dexamethasone does not affect the protein binding of docetaxel.

Metabolism

Hepatic. In vitro drug interaction studies revealed that docetaxel is metabolized by the CYP3A4 isoenzyme (1 major, 3 minor metabolites).

Route of elimination

Docetaxel was eliminated in both the urine and feces following oxidative metabolism of the tert-butyl ester group, but fecal excretion was the main elimination route. Within 7 days, urinary and fecal excretion accounted for approximately 6% and 75% of the administered radioactivity, respectively.

Half life

Dose-dependent. Doses of 70 mg per square meter of body surface area (mg/m 2 ) or higher produce a triphasic elimination profile. With lower doses, assay limitations precluded detection of the terminal elimination phase. The half-life of the alpha, beta, and gamma phase are 4 minutes, 36 minutes, and 11.1 hours, respectively.

Clearance
  • 21 L/h/m2 [Total body clearance, cancer patients after IV administration of 20–115 mg/m2]
Toxicity

Oral LD50 in rat is >2000 mg/kg. Anticipated complications of overdosage include: bone marrow suppression, peripheral neurotoxicity, and mucositis. In two reports of overdose, one patient received 150 mg/m2 and the other received 200 mg/m2 as 1-hour infusions. Both patients experienced severe neutropenia, mild asthenia, cutaneous reactions, and mild paresthesia, and recovered without incident.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Docetaxel Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetails
Canalicular multispecific organic anion transporter 1---(G;G) / (C;G)G AlleleADR Directly StudiedPatients with this polymorphism in ABCC2 are at a higher risk of experiencing drug-induced leukopenia and drug-induced neutropenia when treated with docetaxel.Details

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe metabolism of (R)-warfarin can be decreased when combined with Docetaxel.
(S)-WarfarinThe metabolism of (S)-Warfarin can be decreased when combined with Docetaxel.
2-MethoxyethanolThe risk or severity of adverse effects can be increased when Docetaxel is combined with 2-Methoxyethanol.
3,5-diiodothyropropionic acidThe metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Docetaxel.
4-hydroxycoumarinThe metabolism of 4-hydroxycoumarin can be decreased when combined with Docetaxel.
5-androstenedioneThe metabolism of 5-androstenedione can be decreased when combined with Docetaxel.
6-Deoxyerythronolide BThe metabolism of Docetaxel can be decreased when combined with 6-Deoxyerythronolide B.
6-O-benzylguanineThe metabolism of 6-O-benzylguanine can be decreased when combined with Docetaxel.
9-(N-methyl-L-isoleucine)-cyclosporin AThe risk or severity of adverse effects can be increased when Docetaxel is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
AbataceptThe risk or severity of adverse effects can be increased when Docetaxel is combined with Abatacept.
Food Interactions
Not Available

References

Synthesis Reference

Nicholas J. Sisti, Charles S. Swindell, "Method for docetaxel synthesis." U.S. Patent US5688977, issued September, 1991.

US5688977
General References
Not Available
External Links
Human Metabolome Database
HMDB0015378
KEGG Drug
D02165
KEGG Compound
C11231
PubChem Compound
148124
PubChem Substance
46506766
ChemSpider
130581
BindingDB
36351
ChEBI
4672
ChEMBL
CHEMBL92
Therapeutic Targets Database
DAP000590
PharmGKB
PA449383
HET
TXL
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Docetaxel
ATC Codes
L01CD02 — Docetaxel
AHFS Codes
  • 10:00.00 — Antineoplastic Agents
PDB Entries
1ia0 / 1tub
FDA label
Download (140 KB)
MSDS
Download (100 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentCancer, Breast1
0CompletedTreatmentHead and Neck Carcinoma1
0RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
0RecruitingTreatmentProstate Cancer1
1Active Not RecruitingOtherAdvanced Solid Tumors, Neoplasms, Advanced Solid1
1Active Not RecruitingOtherProstate Cancer1
1Active Not RecruitingTreatmentAdvanced Breast Cancer1
1Active Not RecruitingTreatmentAdvanced Malignancies / Cancer, Advanced1
1Active Not RecruitingTreatmentCancer, Breast / Colon Neoplasms / Lung Cancers / Malignant Neoplasm of Colon / Melanoma / Neoplasms, Breast / Renal Cancers1
1Active Not RecruitingTreatmentFumarate Hydratase (FH)-Deficient Tumors / Lung Cancer Non-Small Cell Cancer (NSCLC) / Mesothelioma / Renal Cell Adenocarcinoma / Succinate Dehydrogenase (SDH)-Deficient Gastrointestinal Stromal Tumors (GIST) / Succinate Dehydrogenase (SDH)-Deficient Non-gastrointestinal Stromal Tumors / Triple-Negative Breast Cancer (TNBC) / Tumors Harboring Amplifications in the cMyc Gene / Tumors Harboring Isocitrate Dehydrogenase-1 (IDH1) and IDH2 Mutations / Tumors, Solid1
1Active Not RecruitingTreatmentHER2 Positive Breast Cancers / Her2-negative Metastatic Breast Cancer / HER2-positive Metastatic Breast Cancer / Locally Advanced or Early Breast Cancer1
1Active Not RecruitingTreatmentHead and Neck Squamous Cell Carcinoma (HNSCC) / Stage III Laryngeal Squamous Cell Carcinoma / Stage III Oral Cavity Squamous Cell Carcinoma / Stage III Oropharyngeal Squamous Cell Carcinoma / Stage IVA Laryngeal Squamous Cell Carcinoma / Stage IVA Oral Cavity Squamous Cell Carcinoma / Stage IVA Oropharyngeal Squamous Cell Carcinoma / Stage IVB Laryngeal Squamous Cell Carcinoma / Stage IVB Oral Cavity Squamous Cell Carcinoma / Stage IVB Oropharyngeal Squamous Cell Carcinoma1
1Active Not RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1Active Not RecruitingTreatmentLung Cancers / Stage IB Non-Small Cell Lung Carcinoma AJCC v7 / Stage II Non-Small Cell Lung Cancer AJCC v7 / Stage IIA Non-Small Cell Lung Carcinoma AJCC v7 / Stage IIB Non-Small Cell Lung Carcinoma AJCC v7 / Stage IIIA Non-Small Cell Lung Cancer AJCC v71
1Active Not RecruitingTreatmentNeoplasms, Breast1
1Active Not RecruitingTreatmentNeoplasms / Solid Cancers1
1Active Not RecruitingTreatmentProstate Cancer2
1Active Not RecruitingTreatmentSquamous Cell Carcinoma of the Head and Neck (SCCHN)1
1CompletedNot AvailableMalignant Neoplasm of Stomach1
1CompletedOtherHealthy Volunteers1
1CompletedTreatmentAdenocarcinoma of the Prostate1
1CompletedTreatmentAdenocarcinoma of the Prostate / Advanced Solid Tumors1
1CompletedTreatmentAdvanced Neoplastic Disease1
1CompletedTreatmentAdvanced Non-Hematologic Malignancies1
1CompletedTreatmentAdvanced Solid Tumors5
1CompletedTreatmentAdvanced Solid Tumors / Lung Cancer Non-Small Cell Cancer (NSCLC)1
1CompletedTreatmentBladder Cancers / Cancer of the Ovary / Cancer, Breast / Carcinoma of Unknown Primary / Esophageal Cancers / Head and Neck Carcinoma / Lung Cancers / Malignant Neoplasm of Pancreas / Malignant Neoplasm of Stomach / Melanoma (Skin) / Prostate Cancer / Sarcomas1
1CompletedTreatmentBladder Cancers / Cancer of the Ovary / Cancer, Breast / Lung Cancers / Prostate Cancer / Renal Cancers / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentBreast Cancer, Non-small Lung Cancer1
1CompletedTreatmentBrenner Tumor / Fallopian Tube Cancer / Ovarian Carcinosarcoma / Ovarian Clear Cell Cystadenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Mixed Epithelial Carcinoma / Ovarian Mucinous Cystadenocarcinoma / Ovarian Serous Cystadenocarcinoma / Ovarian Undifferentiated Adenocarcinoma / Primary Peritoneal Cavity Cancer / Stage II Ovarian Epithelial Cancer / Stage III Ovarian Epithelial Cancer / Stage IV Ovarian Epithelial Cancer1
1CompletedTreatmentCancer of the Ovary1
1CompletedTreatmentCancer of the Ovary / Cancer, Breast / Cervical Cancers / Endometrial Cancers / Fallopian Tube Cancer / Malignant Peritoneal Neoplasm1
1CompletedTreatmentCancer of the Ovary / Cancer, Breast / Esophageal Cancers / Head and Neck Carcinoma / Lung Cancers / Malignant Neoplasm of Stomach / Prostate Cancer1
1CompletedTreatmentCancer of the Ovary / Cancer, Breast / Head and Neck Carcinoma / Lung Cancers / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentCancer of the Ovary / Cancer, Breast / Malignant Neoplasm of Pancreas / Non-Small Cell Lung / Tumors, Solid1
1CompletedTreatmentCancer of the Ovary / Cervical Cancers / Endometrial Cancers / Fallopian Tube Cancer / Peritoneal Cavity Cancer / Sarcomas / Vaginal Cancers / Vulvar Cancers1
1CompletedTreatmentCancer of the Ovary / Endometrial Cancers / Fallopian Tube Cancer / Primary Peritoneal Cavity Cancer1
1CompletedTreatmentCancer, Advanced3
1CompletedTreatmentCancer, Breast6
1CompletedTreatmentCancer, Breast / Lung Cancer Non-Small Cell Cancer (NSCLC) / Prostate Cancer1
1CompletedTreatmentCancer, Breast / Metastatic Breast Cancer (MBC)1
1CompletedTreatmentCancer, Breast / Neutropenias1
1CompletedTreatmentCancer, Neoplasms, Tumors1
1CompletedTreatmentCarcinoma NOS / Malignancies1
1CompletedTreatmentChemotherapy-Induced Nausea and Vomiting (CINV) / Malignancies1
1CompletedTreatmentEsophageal Cancers2
1CompletedTreatmentFallopian Tube Carcinoma / Primary Peritoneal Carcinoma / Recurrent Ovarian Carcinoma / Stage III Ovarian Cancer / Stage IV Ovarian Cancer1
1CompletedTreatmentHER-2 Gene Amplification1
1CompletedTreatmentHNSCC1
1CompletedTreatmentHead & Neck Cancer1
1CompletedTreatmentHead and Neck Carcinoma3
1CompletedTreatmentHead and Neck Carcinoma / Malignant Neoplasm of Thyroid / Melanoma / Parotid Gland Cancer / Stage IV Head and Neck Cancer / Thyroid neoplasms malignant1
1CompletedTreatmentHead and Neck Carcinoma / Salivary Gland Tumors1
1CompletedTreatmentImpaired Renal Function1
1CompletedTreatmentLocally Advanced Sarcoma / Metastatic Sarcoma / Sarcomas / Soft Tissue Sarcoma (STS) / Unresectable Sarcoma1
1CompletedTreatmentLocally Advanced, Metastatic Solid Tumors1
1CompletedTreatmentLocally Recurrent and Metastatic Breast Cancer1
1CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)3
1CompletedTreatmentLung Cancers1
1CompletedTreatmentMalignancies5
1CompletedTreatmentMalignancies / Neoplasms1
1CompletedTreatmentMalignancies / Neoplasms / Tumors1
1CompletedTreatmentMalignant Diseases1
1CompletedTreatmentMalignant Neoplasm of Pancreas1
1CompletedTreatmentMalignant Neoplasm of Stomach1
1CompletedTreatmentMetastatic Breast Cancer (MBC)1
1CompletedTreatmentMetastatic Cancers1
1CompletedTreatmentMetastatic Hormone Refractory Prostate Cancer1
1CompletedTreatmentMetastatic Melanoma1
1CompletedTreatmentMetastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma / Recurrent Metastatic Squamous Neck Cancer With Occult Primary / Recurrent Salivary Gland Cancer / Recurrent Squamous Cell Carcinoma of the Hypopharynx / Recurrent Squamous Cell Carcinoma of the Larynx / Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity / Recurrent Squamous Cell Carcinoma of the Nasopharynx / Recurrent Squamous Cell Carcinoma of the Oropharynx / Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Recurrent Verrucous Carcinoma of the Larynx / Recurrent Verrucous Carcinoma of the Oral Cavity / Salivary Gland Squamous Cell Carcinoma / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IV Squamous Cell Carcinoma of the Nasopharynx / Stage IVA Oral Cavity Squamous Cell Carcinoma / Stage IVA Salivary Gland Cancer / Stage IVA Squamous Cell Carcinoma of the Larynx / Stage IVA Squamous Cell Carcinoma of the Oropharynx / Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IVA Verrucous Carcinoma of the Larynx / Stage IVA Verrucous Carcinoma of the Oral Cavity / Stage IVB Salivary Gland Cancer / Stage IVB Squamous Cell Carcinoma of the Larynx / Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IVB Squamous Cell Carcinoma of the Oropharynx / Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IVB Verrucous Carcinoma of the Larynx / Stage IVB Verrucous Carcinoma of the Oral Cavity / Stage IVC Salivary Gland Cancer / Stage IVC Squamous Cell Carcinoma of the Larynx / Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IVC Squamous Cell Carcinoma of the Oropharynx / Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IVC Verrucous Carcinoma of the Larynx / Stage IVC Verrucous Carcinoma of the Oral Cavity / Tongue Cancer / Untreated Metastatic Squamous Neck Cancer With Occult Primary1
1CompletedTreatmentMetastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma / Stage III Squamous Cell Carcinoma of the Hypopharynx / Stage III Squamous Cell Carcinoma of the Larynx / Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage III Squamous Cell Carcinoma of the Nasopharynx / Stage III Squamous Cell Carcinoma of the Oropharynx / Stage III Verrucous Carcinoma of the Larynx / Stage III Verrucous Carcinoma of the Oral Cavity / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IV Squamous Cell Carcinoma of the Nasopharynx / Stage IVA Squamous Cell Carcinoma of the Larynx / Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IVA Squamous Cell Carcinoma of the Oropharynx / Stage IVA Verrucous Carcinoma of the Larynx / Stage IVA Verrucous Carcinoma of the Oral Cavity / Stage IVB Squamous Cell Carcinoma of the Larynx / Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IVB Squamous Cell Carcinoma of the Oropharynx / Stage IVB Verrucous Carcinoma of the Larynx / Stage IVB Verrucous Carcinoma of the Oral Cavity / Stage IVC Squamous Cell Carcinoma of the Larynx / Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IVC Squamous Cell Carcinoma of the Oropharynx / Stage IVC Verrucous Carcinoma of the Larynx / Stage IVC Verrucous Carcinoma of the Oral Cavity / Tongue Cancer / Untreated Metastatic Squamous Neck Cancer With Occult Primary1
1CompletedTreatmentNeoplasms7
1CompletedTreatmentNeoplasms Malignant1
1CompletedTreatmentNeoplasms, Breast1
1CompletedTreatmentNeoplasms, Breast / Solid Tumor Cancers1
1CompletedTreatmentNeoplasms, Esophageal1
1CompletedTreatmentNeoplasms, Head and Neck1
1CompletedTreatmentNeoplasms, Malignant1
1CompletedTreatmentNon-Small Cell Lung Cancer Recurrent / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer1
1CompletedTreatmentOvarian Carcinoma1
1CompletedTreatmentProstate Cancer9
1CompletedTreatmentProstatic Neoplasms2
1CompletedTreatmentRecurrent Prostate Cancer / Stage IV Prostate Cancer / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentResistant Solid Malignancies1
1CompletedTreatmentSarcomas1
1CompletedTreatmentSolid Cancers1
1CompletedTreatmentSolid Tumor Cancers1
1CompletedTreatmentSolid Tumor Malignancies1
1CompletedTreatmentSquamous Cell Carcinoma of Esophagus1
1CompletedTreatmentSquamous Cell Carcinoma of the Head and Neck (SCCHN)1
1CompletedTreatmentTumors1
1CompletedTreatmentTumors, Solid7
1CompletedTreatmentUnspecified Adult Solid Tumor, Protocol Specific18
1Not Yet RecruitingTreatmentBladder Small Cell Neuroendocrine Carcinoma / Castration-Resistant Prostate Carcinoma / Metastatic Bladder Urothelial Carcinoma / Metastatic Urethral Urothelial Carcinoma / Prostate Carcinoma Metastatic in the Bone / Prostate Neuroendocrine Neoplasm / Prostate Small Cell Carcinoma / Stage III Bladder Cancer AJCC v8 / Stage III Prostate Cancer AJCC v8 / Stage III Urethral Cancer AJCC v8 / Stage IV Bladder Cancer AJCC v8 / Stage IV Prostate Cancer AJCC v8 / Stage IV Urethral Cancer AJCC v8 / Stage IVA Bladder Cancer AJCC v8 / Stage IVB Bladder Cancer AJCC v8 / Transitional Cell Carcinoma / Ureter Small Cell Carcinoma1
1RecruitingBasic ScienceNeoplasms1
1RecruitingBasic ScienceSoft Tissue Sarcoma Adult1
1RecruitingOtherNeoplasms, Advanced Solid2
1RecruitingTreatmentAdenocarcinoma of the Pancreas / Head and Neck Squamous Cell Carcinoma (HNSCC) / Non-Resectable Cholangiocarcinoma / Pancreatic Adenocarcinoma Metastatic / Recurrent Gallbladder Carcinoma / Recurrent Non-Small Cell Lung Carcinoma / Stage III Pancreatic Cancer / Stage IIIA Gallbladder Cancer / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIB Gallbladder Cancer / Stage IIIb Non-small Cell Lung Cancer / Stage IV Gallbladder Cancer / Stage IV Non-Small Cell Lung Cancer / Stage IV Pancreatic Cancer / Unresectable Gallbladder Carcinoma / Unresectable Pancreatic Cancer1
1RecruitingTreatmentAdvanced Malignant Solid Neoplasm / Anatomic Stage III Breast Cancer AJCC v8 / Anatomic Stage IIIA Breast Cancer AJCC v8 / Anatomic Stage IIIB Breast Cancer AJCC v8 / Anatomic Stage IIIC Breast Cancer AJCC v8 / Anatomic Stage IV Breast Cancer AJCC v8 / Castration-Resistant Prostate Carcinoma / Estrogen Receptor Negative / Estrogen Receptor Positive / HER2/Neu Negative / Metastatic Hormone Refractory Prostate Cancer / Metastatic Malignant Solid Neoplasm / PIK3CB Gene Mutation / Progesterone Receptor Negative / Prognostic Stage III Breast Cancer AJCC v8 / Prognostic Stage IIIA Breast Cancer AJCC v8 / Prognostic Stage IIIB Breast Cancer AJCC v8 / Prognostic Stage IIIC Breast Cancer AJCC v8 / Prognostic Stage IV Breast Cancer AJCC v8 / PTEN gene mutation / PTEN Loss / Stage III Prostate Cancer AJCC v8 / Stage IIIA Prostate Cancer AJCC v8 / Stage IIIB Prostate Cancer AJCC v8 / Stage IIIC Prostate Cancer AJCC v8 / Stage IV Prostate Cancer AJCC v8 / Stage IVA Prostate Cancer AJCC v8 / Stage IVB Prostate Cancer AJCC v8 / Triple-Negative Breast Carcinoma / Unresectable Solid Neoplasm1
1RecruitingTreatmentAdvanced Solid Tumors / Advanced Solid Tumors Cancer1
1RecruitingTreatmentEGFR Negative Non-Small Cell Lung Cancer / Lung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancers / Metastatic Non-Small Cell Lung Cancer / Non-Small Cell Lung Cancer Stage IIIB / Stage IV Non-Small Cell Lung Cancer1
1RecruitingTreatmentHead and Neck Carcinoma2
1RecruitingTreatmentInflammatory carcinoma of the breast1
1RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1RecruitingTreatmentMetastatic Castration Resistant Prostate Cancer / Prostatic Neoplasms1
1RecruitingTreatmentMetastatic Gastric Adenocarcinoma1
1RecruitingTreatmentMetastatic Hormone Refractory Prostate Cancer1
1RecruitingTreatmentMetastatic Urothelial Carcinoma of the Renal Pelvis and Ureter / Recurrent Bladder Carcinoma / Recurrent Urothelial Carcinoma of the Renal Pelvis and Ureter / Regional Urothelial Carcinoma of the Renal Pelvis and Ureter / Stage III Bladder Urothelial Carcinoma / Stage III Urethral Cancer / Stage IV Bladder Urothelial Carcinoma / Stage IV Urethral Cancer / Urethral Urothelial Carcinoma1
1RecruitingTreatmentNon-Small Cell Lung Cancer Recurrent1
1RecruitingTreatmentNon-Small Cell Lung Carcinoma (NSCLC)1
1RecruitingTreatmentProstate Cancer1
1RecruitingTreatmentProstatic Neoplasms1
1RecruitingTreatmentSquamous Cell Carcinoma of Esophagus1
1RecruitingTreatmentTransitional Cell Carcinoma1
1RecruitingTreatmentTumors, Solid1
1SuspendedTreatmentMalignancies1
1TerminatedNot AvailableNon-hematologic Malignancies / Pharmacokinetics of ASP98531
1TerminatedTreatmentAdenocarcinoma of the Lung / Bronchoalveolar Cell Lung Cancer / Large Cell Lung Cancer / Squamous Cell Carcinoma of Lung / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIb Non-small Cell Lung Cancer1
1TerminatedTreatmentAdenocarcinomas of the Gastroesophageal Junction / Esophageal Cancers1
1TerminatedTreatmentAdvanced Malignancies, Non-small Cell Lung Cancer1
1TerminatedTreatmentAdvanced Solid Tumors2
1TerminatedTreatmentAny Cancer / Cancer, Breast1
1TerminatedTreatmentBladder Cancers / Lung Cancer Non-Small Cell Cancer (NSCLC) / Non-small Cell Lung, Prostate, Bladder/Urothelial Cancers / Prostate Cancer / Transitional Cell Carcinoma1
1TerminatedTreatmentBreast Cancer Metastatic1
1TerminatedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Peritoneal Cavity Cancer / Primary Peritoneal Cavity Cancer1
1TerminatedTreatmentCancer, Breast1
1TerminatedTreatmentCancer, Breast / Carcinoma, Colorectal / Lung Cancers / Prostate Cancer / Soft Tissue Sarcoma (STS)1
1TerminatedTreatmentCancer, Breast / Lung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancers / Malignant Neoplasm of Stomach / Prostate Cancer / Pulmonary Cancer1
1TerminatedTreatmentCervical Cancers1
1TerminatedTreatmentExtensive Stage Small Cell Lung Cancer / Metastatic Colon Cancer / Non-Small Cell Lung Cancer Recurrent / Recurrent Colon Cancer / Recurrent Rectal Cancer / Refractory Small cell lung cancer / Stage IV Non-Small Cell Lung Cancer / Stage IV Rectal Cancer1
1TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)2
1TerminatedTreatmentLung Cancers2
1TerminatedTreatmentNeoplasms1
1TerminatedTreatmentNeoplasms, Advanced or Metastatic1
1TerminatedTreatmentProstate Cancer1
1TerminatedTreatmentProstate Cancer / Prostate Cancer Metastatic Disease / Urologic Neoplasms1
1TerminatedTreatmentSquamous Non-Small Cell Lung Cancer1
1TerminatedTreatmentTumors1
1TerminatedTreatmentUnspecified Adult Solid Tumor, Protocol Specific1
1Unknown StatusTreatmentCancer, Advanced1
1Unknown StatusTreatmentProstate Cancer2
1Unknown StatusTreatmentTumors, Solid1
1WithdrawnTreatmentCancer of the Ovary / Ovarian Carcinoma / Recurrent Ovarian Cancer / Recurrent Ovarian Carcinoma1
1WithdrawnTreatmentCancer, Breast1
1WithdrawnTreatmentCancer, Breast / Head and Neck Carcinoma / Lung Cancers / Prostate Cancer / Unspecified Adult Solid Tumor, Protocol Specific1
1WithdrawnTreatmentChemotherapeutic Agent Toxicity / Lung Cancers1
1WithdrawnTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1WithdrawnTreatmentProstatic Neoplasms1
1WithdrawnTreatmentRecurrent Non-Small Cell Lung Carcinoma / Stage IV Non-Small Cell Lung Cancer1
1WithdrawnTreatmentTumors, Solid1
1, 2Active Not RecruitingTreatmentAdenocarcinoma of the Prostate / Hormone-Resistant Prostate Cancer / Recurrent Prostate Cancer / Stage IV Prostate Cancer1
1, 2Active Not RecruitingTreatmentEsophageal Cancers1
1, 2Active Not RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)2
1, 2Active Not RecruitingTreatmentPancreatic Adenocarcinoma Metastatic1
1, 2Active Not RecruitingTreatmentProstate Cancer2
1, 2Active Not RecruitingTreatmentProstatic Neoplasms1
1, 2CompletedTreatmentAdult Solid Neoplasm / Inflammatory Breast Carcinoma / Male Breast Carcinoma / Stage IIIA Breast Cancer / Stage IIIB Breast Cancer1
1, 2CompletedTreatmentAdvanced Squamous Cell Carcinoma / Squamous Cell Carcinoma of the Head and Neck (SCCHN) / SSCHN1
1, 2CompletedTreatmentBladder Cancers / Cancer of the Ovary / Cancer, Breast / Colorectal Cancers / Esophageal Cancers / Head and Neck Carcinoma / Lung Cancers / Prostate Cancer / Renal Cancers / Unspecified Adult Solid Tumor, Protocol Specific1
1, 2CompletedTreatmentBone Metastases / Castration-Resistant Prostate Cancer (CRPC)1
1, 2CompletedTreatmentCancer of Head and Neck / Head and Neck Carcinoma / Head Cancer / Neck Cancer / Neoplasms, Neck1
1, 2CompletedTreatmentCancer of the Breast1
1, 2CompletedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Peritoneal Cavity Cancer1
1, 2CompletedTreatmentCancer, Breast6
1, 2CompletedTreatmentCarcinoma of Head and/or Neck / Squamous Cell Carcinoma (SCC)1
1, 2CompletedTreatmentCastrate-resistant Prostate Cancer (CRPC)1
1, 2CompletedTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Precancerous/Nonmalignant Condition / Unspecified Adult Solid Tumor, Protocol Specific1
1, 2CompletedTreatmentEsophageal Cancers3
1, 2CompletedTreatmentEsophagus Cancer1
1, 2CompletedTreatmentFallopian Tube Cancer / Malignant Tumor of Peritoneum / Recurrent Ovarian Epithelial Cancer1
1, 2CompletedTreatmentGastrointestinal Diseases1
1, 2CompletedTreatmentHead and Neck Carcinoma1
1, 2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)2
1, 2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Squamous Cell Carcinoma of the Head and Neck (SCCHN)1
1, 2CompletedTreatmentLung Cancers4
1, 2CompletedTreatmentLung Cancers / Unspecified Adult Solid Tumor, Protocol Specific1
1, 2CompletedTreatmentMalignancies1
1, 2CompletedTreatmentMalignant Neoplasm of Stomach2
1, 2CompletedTreatmentMalignant Neoplasm of Stomach / Unspecified Adult Solid Tumor, Protocol Specific1
1, 2CompletedTreatmentMetastatic Breast Cancer (MBC)2
1, 2CompletedTreatmentMetastatic Hormone Refractory Prostate Cancer1
1, 2CompletedTreatmentMetastatic, Androgen Independent Prostate Cancer / Prostate Cancer1
1, 2CompletedTreatmentNeoplasms, Breast1
1, 2CompletedTreatmentNeoplasms, Esophageal / Stomach Neoplasms1
1, 2CompletedTreatmentNeoplasms, Head and Neck1
1, 2CompletedTreatmentNon-Small Cell Lung Cancer Recurrent / Recurrent Prostate Cancer / Stage III Prostate Cancer / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer / Stage IV Prostate Cancer / Unspecified Adult Solid Tumor, Protocol Specific1
1, 2CompletedTreatmentNon-Small Cell Lung Cancer Recurrent / Squamous Cell Carcinoma of Lung1
1, 2CompletedTreatmentOperable Soft Tissue Sarcoma / Stage III Adult Soft Tissue Sarcoma1
1, 2CompletedTreatmentOropharynx Cancers / Squamous Cell Carcinoma of the Oral Cavity1
1, 2CompletedTreatmentProstate Cancer6
1, 2CompletedTreatmentProstate Cancer / Tumors1
1, 2CompletedTreatmentProstatic Neoplasms2
1, 2CompletedTreatmentRecurrent Salivary Gland Cancer / Recurrent Squamous Cell Carcinoma of the Hypopharynx / Recurrent Squamous Cell Carcinoma of the Larynx / Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity / Recurrent Squamous Cell Carcinoma of the Nasopharynx / Recurrent Squamous Cell Carcinoma of the Oropharynx / Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Salivary Gland Squamous Cell Carcinoma / Stage III Salivary Gland Cancer / Stage III Squamous Cell Carcinoma of the Hypopharynx / Stage III Squamous Cell Carcinoma of the Larynx / Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage III Squamous Cell Carcinoma of the Nasopharynx / Stage III Squamous Cell Carcinoma of the Oropharynx / Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IV Salivary Gland Cancer / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IV Squamous Cell Carcinoma of the Larynx / Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IV Squamous Cell Carcinoma of the Nasopharynx / Stage IV Squamous Cell Carcinoma of the Oropharynx / Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity1
1, 2CompletedTreatmentStomach Neoplasms1
1, 2CompletedTreatmentTumors, Solid1
1, 2CompletedTreatmentUnspecified Adult Solid Tumor, Protocol Specific1
1, 2Not Yet RecruitingTreatmentBladder Cancers / Cancer of the Bladder / Genitourinary tract neoplasm / Malignant Tumor of the Urinary Bladder / Transitional Cell Carcinoma / Urinary Bladder Cancer / Urinary Bladder Neoplasms / Urologic Cancer / Urologic Neoplasms1
1, 2Not Yet RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2Not Yet RecruitingTreatmentRecurrent Osteosarcoma / Refractory Osteosarcoma1
1, 2RecruitingTreatmentAdvanced Gastric Adenocarcinoma1
1, 2RecruitingTreatmentAdvanced Solid Tumors / Lung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2RecruitingTreatmentCancer, Breast / Cholangiocarcinomas / Endometrial Cancers / Lung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancers / Malignant Neoplasm of Stomach / Malignant Solid Tumours / MPN / MPN (Myeloproliferative Neoplasms) / Multiple Myeloma (MM) / Neoplasms, Endometrial / NSCLC (Non-small Cell Lung Carcinoma) / Solid Tumors and Hematologic Malignancy / Stomach Neoplasms / Transitional Cell Carcinoma / Tumors, Solid / UC (Urothelial Cancer)1
1, 2RecruitingTreatmentCastration Levels of Testosterone / Castration-Resistant Prostate Carcinoma / Hormone-Resistant Prostate Cancer / Metastatic Hormone Refractory Prostate Cancer / Prostate Carcinoma Metastatic in the Bone / PSA Level Greater Than or Equal to Two / PSA Progression / Recurrent Prostate Carcinoma / Stage IV Prostate Cancer / Stage IV Prostate Cancer AJCC v71
1, 2RecruitingTreatmentColorectal Adenocarcinoma (CRC) / Gastric Adenocarcinoma / Renal Cell Adenocarcinoma / Transitional Cell Carcinoma1
1, 2RecruitingTreatmentColorectal Cancers1
1, 2RecruitingTreatmentHead and Neck Carcinoma1
1, 2RecruitingTreatmentLocally Advanced or Metastatic Urothelial Cell Carcinoma / Urinary Bladder Diseases / Urological Diseases1
1, 2RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Neoplasms, Colorectal / Neoplasms, Gastrointestinal / Neoplasms, Pancreatic1
1, 2RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Non-Small Cell Lung Cancer Recurrent / Progression of Non-small Cell Lung Cancer1
1, 2RecruitingTreatmentMalignant Neoplasm of Stomach1
1, 2RecruitingTreatmentMetastatic Triple Negative Breast Cancer1
1, 2RecruitingTreatmentProstate Cancer1
1, 2RecruitingTreatmentSarcomas1
1, 2RecruitingTreatmentSoft Tissue Sarcoma (STS)1
1, 2SuspendedTreatmentMalignant Neoplasm of Stomach1
1, 2TerminatedTreatmentAdenocarcinoma of the Prostate / Prostate Cancer / Recurrent Prostate Cancer / Stage I Prostate Cancer / Stage III Prostate Cancer / Stage IV Prostate Cancer1
1, 2TerminatedTreatmentCancer, Advanced / Cancer, Breast / Lung Cancer Small Cell Lung Cancer (SCLC) / Malignant Neoplasm of Pancreas / Ovarian / Sarcomas1
1, 2TerminatedTreatmentCancer, Breast / Her2-Positive Breast Cancer1
1, 2TerminatedTreatmentCancer, Breast / Metastatic Breast Cancer (MBC)1
1, 2TerminatedTreatmentER-positive Breast Cancer / Her2-Positive Breast Cancer1
1, 2TerminatedTreatmentExtensive Stage Unresectable / Lung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2TerminatedTreatmentHead and Neck Carcinoma1
1, 2TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)2
1, 2TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancers1
1, 2TerminatedTreatmentLung Cancers1
1, 2TerminatedTreatmentMale Breast Cancer / Stage IIIA Breast Cancer / Stage IIIB Breast Cancer / Stage IIIC Breast Cancer / Stage IV Breast Cancer1
1, 2TerminatedTreatmentPain NOS / Prostate Cancer1
1, 2TerminatedTreatmentProstate Cancer2
1, 2TerminatedTreatmentProstate Cancer / Prostatic Neoplasms1
1, 2Unknown StatusTreatmentAdvanced Gastric Cancer1
1, 2Unknown StatusTreatmentCancer of the Esophagus / Gastric Cardia Carcinoma1
1, 2Unknown StatusTreatmentCancer of the Ovary1
1, 2Unknown StatusTreatmentDrug/Agent Toxicity by Tissue/Organ / Lung Cancers1
1, 2Unknown StatusTreatmentEsophageal Cancers1
1, 2Unknown StatusTreatmentHormone Refractory Prostate Cancer1
1, 2Unknown StatusTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)2
1, 2Unknown StatusTreatmentNeoplasms, Head and Neck1
1, 2Unknown StatusTreatmentProstate Cancer1
1, 2WithdrawnTreatmentCervical Cancers1
1, 2WithdrawnTreatmentLung Cancers1
1, 2WithdrawnTreatmentRecurrent Squamous Cell Lung Carcinoma / Stage IV Squamous Cell Lung Carcinoma1
1, 2WithdrawnTreatmentStage IIIB Non-Small Cell Lung Cancer AJCC v7 / Stage IV Non-Small Cell Lung Cancer AJCC v71
2Active Not RecruitingNot AvailableAdenocarcinoma of the Gastro-oesophageal Junction / Metastatic Gastric Cancers1
2Active Not RecruitingBasic ScienceStage II Breast Cancer / Stage IIIA Breast Cancer / Stage IIIB Breast Cancer / Stage IIIC Breast Cancer1
2Active Not RecruitingPreventionStage III Prostate Cancer / Stage IV Prostate Cancer1
2Active Not RecruitingTreatmentAdenocarcinoma of the Lung / Adenosquamous Cell Lung Cancer / Adenosquamous Lung Carcinoma / Bronchoalveolar Cell Lung Cancer / Large Cell Lung Cancer / Large Cell Lung Carcinoma / Minimally Invasive Lung Adenocarcinoma / Squamous Cell Carcinoma of Lung / Squamous Cell Lung Carcinoma / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIA Non-Small Cell Lung Cancer AJCC v7 / Stage IIIb Non-small Cell Lung Cancer / Stage IIIB Non-Small Cell Lung Cancer AJCC v71
2Active Not RecruitingTreatmentAdenocarcinoma, Prostate / Hormone-Resistant Prostate Cancer / Recurrent Prostate Carcinoma / Stage IV Prostate Cancer1
2Active Not RecruitingTreatmentAdenocarcinomas of the Gastroesophageal Junction / Esophageal Cancers / Malignant Neoplasm of Stomach2
2Active Not RecruitingTreatmentAdenocarcinomas of the Gastroesophageal Junction / Gastric Adenocarcinoma / Malignant Neoplasm of Stomach1
2Active Not RecruitingTreatmentAdvanced Gastric Cancer1
2Active Not RecruitingTreatmentAdvanced Non-Small Cell Lung Cancer1
2Active Not RecruitingTreatmentAnal Canal Carcinoma1
2Active Not RecruitingTreatmentCancer, Breast11
2Active Not RecruitingTreatmentCarcinoma, Squamous Cell of Head and Neck1
2Active Not RecruitingTreatmentChemoradiation / Neoplasms, Esophageal1
2Active Not RecruitingTreatmentHead and Neck Carcinoma6
2Active Not RecruitingTreatmentHead and Neck Carcinoma / Larynx1
2Active Not RecruitingTreatmentHead and Neck Carcinoma / Metastatic Squamous Cell Carcinoma of the Hypopharynx / Metastatic Squamous Cell Carcinoma of the Larynx / Metastatic Squamous Cell Carcinoma of the Oral Cavity / Metastatic Squamous Cell Carcinoma of the Oropharynx / Recurrent Hypopharyngeal Squamous Cell Carcinoma / Recurrent Laryngeal Squamous Cell Carcinoma / Recurrent Oral Cavity Squamous Cell Carcinoma / Recurrent Oropharyngeal Squamous Cell Carcinoma / Squamous Cell Carcinoma of the Head and Neck (SCCHN) / Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7 / Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IVA Hypopharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7 / Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IVB Hypopharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7 / Stage IVB Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IVC Hypopharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IVC Laryngeal Squamous Cell Carcinoma AJCC v7 / Stage IVC Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage IVC Oropharyngeal Squamous Cell Carcinoma AJCC v71
2Active Not RecruitingTreatmentHead and Neck Squamous Cell Carcinoma (HNSCC)2
2Active Not RecruitingTreatmentHead-and-neck Cancer / Squamous Cell Carcinoma (SCC)1
2Active Not RecruitingTreatmentHuman Papillomavirus Infections / Stage I Oropharyngeal Squamous Cell Carcinoma / Stage II Oropharyngeal Squamous Cell Carcinoma / Stage III Oropharyngeal Squamous Cell Carcinoma / Stage IVA Oropharyngeal Squamous Cell Carcinoma / Stage IVB Oropharyngeal Squamous Cell Carcinoma1
2Active Not RecruitingTreatmentHypopharyngeal Cancer1
2Active Not RecruitingTreatmentKRAS Gene Mutation / Recurrent Non-Small Cell Lung Carcinoma / Stage IV Non-Small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer AJCC v71
2Active Not RecruitingTreatmentLaryngeal Cancer1
2Active Not RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
2Active Not RecruitingTreatmentLung Cancers1
2Active Not RecruitingTreatmentMalignant Neoplasm of Female Breast1
2Active Not RecruitingTreatmentMalignant Neoplasm of Pancreas1
2Active Not RecruitingTreatmentMalignant Neoplasm of Stomach3
2Active Not RecruitingTreatmentMalignant Neoplasm of Stomach / Unresectable1
2Active Not RecruitingTreatmentMalignant Tumor of the Breast / Neoplasms, Breast1
2Active Not RecruitingTreatmentMelanoma1
2Active Not RecruitingTreatmentMetastatic Breast Cancer (MBC)1
2Active Not RecruitingTreatmentMetastatic Colorectal Adenocarcinoma1
2Active Not RecruitingTreatmentNeoplasms1
2Active Not RecruitingTreatmentNeoplasms, Breast1
2Active Not RecruitingTreatmentNon Small Cell Lung Carcinoma (NSCLC)1
2Active Not RecruitingTreatmentProstate Cancer2
2Active Not RecruitingTreatmentProstatic Neoplasms1
2Active Not RecruitingTreatmentSarcomas1
2Active Not RecruitingTreatmentSinonasal Tumors1
2Active Not RecruitingTreatmentSquamous Cell Carcinoma of Esophagus1
2Active Not RecruitingTreatmentSquamous Cell Carcinoma of the Hypopharynx Stage III / Squamous Cell Carcinoma of the Hypopharynx Stage IV / Squamous Cell Carcinoma of the Larynx Stage III / Squamous Cell Carcinoma of the Larynx Stage IV / Squamous Cell Carcinoma of the Oral Cavity Stage III / Squamous Cell Carcinoma of the Oral Cavity Stage IV / Squamous Cell Carcinoma of the Oropharynx Stage III / Squamous Cell Carcinoma of the Oropharynx Stage IV1
2Active Not RecruitingTreatmentThyroid Gland Undifferentiated (Anaplastic) Carcinoma1
2Active Not RecruitingTreatmentTriple-Negative Breast Cancer (TNBC)1
2Active Not RecruitingTreatmentUnresectable Sinonasal Tumors1
2CompletedNot AvailableLung Cancer Non-Small Cell Cancer (NSCLC)1
2CompletedNot AvailableMetastatic Hormone Refractory Prostate Cancer1
2CompletedPreventionGrade 3/4 Neutropenia / Neutropenia, Febrile1
2CompletedPreventionProstate Cancer1
2CompletedPreventionUnresectable Locally Advanced NSCLC1
2CompletedTreatmentAbdominal wall neoplasm / Ovarian Carcinoma1
2CompletedTreatmentAdenocarcinoma Of Esophagus / Gastric Adenocarcinoma1
2CompletedTreatmentAdenocarcinoma of Colon / Adenocarcinoma of Rectum / Metastatic Disease1
2CompletedTreatmentAdenocarcinoma of the Esophagus / Adenocarcinomas of the Gastroesophageal Junction / Recurrent Esophageal Cancer / Squamous Cell Carcinoma of the Esophagus / Stage IV Esophageal Cancer1
2CompletedTreatmentAdenocarcinoma of the Lung / Adenosquamous Cell Lung Cancer / Bronchoalveolar Cell Lung Cancer / Large Cell Lung Cancer / Lung Cancer Non-Small Cell Cancer (NSCLC) / Non-Small Cell Lung Cancer Recurrent / Squamous Cell Carcinoma of Lung / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer1
2CompletedTreatmentAdenocarcinoma of the Lung / Adenosquamous Cell Lung Cancer / Large Cell Lung Cancer / Malignant Pleural Effusions / Non-Small Cell Lung Cancer Recurrent / Squamous Cell Carcinoma of Lung / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer1
2CompletedTreatmentAdenocarcinoma of the Lung / Lung Cancer Non-Small Cell Cancer (NSCLC) / Squamous Cell Carcinoma (SCC)1
2CompletedTreatmentAdenocarcinoma of the Pancreas / Recurrent Pancreatic Cancer / Stage IV Pancreatic Cancer1
2CompletedTreatmentAdenocarcinoma of the Pancreas / Stage IA Pancreatic Cancer / Stage IB Pancreatic Cancer / Stage IIA Pancreatic Cancer / Stage IIB Pancreatic Cancer1
2CompletedTreatmentAdenocarcinoma of the Prostate / Hormone-Resistant Prostate Cancer / Recurrent Prostate Cancer / Stage IV Prostate Cancer1
2CompletedTreatmentAdenocarcinoma of the Prostate / Prostate Cancer2
2CompletedTreatmentAdenocarcinoma of the Prostate / Recurrent Prostate Cancer / Stage I Prostate Cancer / Stage IIA Prostate Cancer / Stage IIB Prostate Cancer / Stage III Prostate Cancer1
2CompletedTreatmentAdenocarcinoma of the Prostate / Recurrent Prostate Cancer / Stage IV Prostate Cancer1
2CompletedTreatmentAdenocarcinoma, Prostate1
2CompletedTreatmentAdenocarcinomas of the Esophagogastric Junction / Malignant Neoplasm of Stomach2
2CompletedTreatmentAdenocarcinomas of the Gastroesophageal Junction / Advanced Unresectable Gastric Cancer / Metastatic Gastric Cancers1
2CompletedTreatmentAdenocarcinomas of the Gastroesophageal Junction / Esophageal Cancers1
2CompletedTreatmentAdenocarcinomas of the Gastroesophageal Junction / Malignant Neoplasm of Stomach1
2CompletedTreatmentAdrenocortical Carcinoma1
2CompletedTreatmentAdvanced Breast Cancer1
2CompletedTreatmentAdvanced Endometrial Adenocarcinoma, Stage III A, B, C1
2CompletedTreatmentAdvanced Gastric Cancer1
2CompletedTreatmentAdvanced Gastric Cancer / Gastro-esophageal Junction Cancer1
2CompletedTreatmentAdvanced Non Small Cell Lung Cancer (NSCLC)1
2CompletedTreatmentAdvanced Non-Small Cell Lung Cancer1
2CompletedTreatmentAdvanced Non-Squamous Non-Small Cell Lung Cancer1
2CompletedTreatmentAmpullary Cancer / Cholangiocarcinoma Cancer / Gallbladder Cancer / Malignant Neoplasm of Pancreas1
2CompletedTreatmentAnemias / Drug/Agent Toxicity by Tissue/Organ / Lung Cancers / Neutropenias1
2CompletedTreatmentBiliary Tract Neoplasms / Neoplasms, Pancreatic1
2CompletedTreatmentBladder Cancers3
2CompletedTreatmentBladder Cancers / Cancer, Breast / Head and Neck Carcinoma / Lung Cancers / Unspecified Adult Solid Tumor, Protocol Specific1
2CompletedTreatmentBladder Cancers / Transitional Cell Cancer of the Renal Pelvis and Ureter / Urethral Cancer1
2CompletedTreatmentBladder Cancers / Transitional Cell Carcinoma2
2CompletedTreatmentBrain and Central Nervous System Tumors / Neuroblastomas / Sarcomas1
2CompletedTreatmentCancer of Esophagus / Cancer of the Esophagus / Esophageal Cancers / Esophagus Cancer / Neoplasms, Esophageal1
2CompletedTreatmentCancer of the Ovary4
2CompletedTreatmentCancer of the Ovary / Extragonadal Germ Cell Tumor / Testicular germ cell tumour1
2CompletedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Malignant Tumor of Peritoneum1
2CompletedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Cavity Cancer3
2CompletedTreatmentCancer of the Ovary / Peritoneal Cavity Cancer3
2CompletedTreatmentCancer of the Ovary / Sarcomas / Small Intestine Cancer1
2CompletedTreatmentCancer, Breast75
2CompletedTreatmentCancer, Breast / Fevers / Neutropenias1
2CompletedTreatmentBrca1 Mutation Carrier / Brca2 Mutation Carrier / Cancer, Breast / Hereditary Breast/Ovarian Cancer (brca1, brca2)1
2CompletedTreatmentCancer, Breast / Lung Cancer Non-Small Cell Cancer (NSCLC)1
2CompletedTreatmentCancer, Breast / Lung Cancers / Prostate Cancer1
2CompletedTreatmentCancer, Breast / Metastatic Breast Cancer (MBC)1
2CompletedTreatmentCancer, Breast / Metastatic Breast Cancer (MBC) / Tumors, Solid1
2CompletedTreatmentCancer, Breast / Neoplasms Metastasis2
2CompletedTreatmentCancer, Breast / Neoplasms, Breast1
2CompletedTreatmentCarcinoma NOS / Nasopharyngeal Neoplasms1
2CompletedTreatmentCarcinoma of Head/Neck / Squamous Cell Carcinoma (SCC)1
2CompletedTreatmentCarcinoma of Larynx / Squamous Cell Carcinoma of the Hypopharynx1
2CompletedTreatmentCarcinoma of Renal Pelvis / Carcinoma of Ureter / Carcinoma of Urinary Tract / Urethral Carcinoma1
2CompletedTreatmentCervical Cancers2
2CompletedTreatmentCervical Squamous Cell Carcinoma / Cervical Squamous Cell Carcinoma, Not Otherwise Specified / Recurrent Cervical Carcinoma1
2CompletedTreatmentCervix Neoplasms1
2CompletedTreatmentCervix Neoplasms / Neoplasms, Lung / Neoplasms, Ovarian / Renal Neoplasms1
2CompletedTreatmentERBB2 Gene Amplification / Neoplasms Metastasis / Stomach Neoplasms1
2CompletedTreatmentEndometrial Cancers2
2CompletedTreatmentEsophageal Cancers4
2CompletedTreatmentEsophageal Cancers / GE Junction Cancer / Malignant Neoplasm of Stomach1
2CompletedTreatmentEsophageal Cancers / Malignant Neoplasm of Stomach7
2CompletedTreatmentFemale Breast Cancer1
2CompletedTreatmentGastric Adenocarcinoma1
2CompletedTreatmentGastric Adenocarcinoma With Peritoneal Carcinomatosis / Siewert Type II Adenocarcinoma of Esophagogastric Junction With Peritoneal Carcinomatosis / Siewert Type III Adenocarcinoma of Esophagogastric Junction With Peritoneal Carcinomatosis1
2CompletedTreatmentGastric Cancer Adenocarcinoma Metastatic1
2CompletedTreatmentGastro Oesophageal Cancer1
2CompletedTreatmentHER-2 Positive Metastatic Breast Cancer1
2CompletedTreatmentHER2 Negative Breast Cancer1
2CompletedTreatmentHead and Neck Carcinoma16
2CompletedTreatmentHead and Neck Carcinoma / Squamous Cell Cancer1
2CompletedTreatmentHead and Neck Squamous Cell Carcinoma (HNSCC)2
2CompletedTreatmentHead and Neck / Head and Neck Carcinoma / Recurrent Disease / Squamous Cell Carcinoma (SCC)1
2CompletedTreatmentHemangiosarcoma / Histiocytoma / Leiomyosarcomas / Malignant Fibrous / Sarcomas1
2CompletedTreatmentHormone Refractory Prostate Cancer1
2CompletedTreatmentHormone Refractory / Metastatic / Prostate Cancer1
2CompletedTreatmentHormone Resistant Prostate Cancer / Metastatic Hormone Refractory Prostate Cancer1
2CompletedTreatmentHormone-Refractory Prostate Cancer2
2CompletedTreatmentIndividualized Chemotherapy1
2CompletedTreatmentLeiomyosarcomas1
2CompletedTreatmentLeiomyosarcomas / Uterine Neoplasms1
2CompletedTreatmentLeukemias1
2CompletedTreatmentLiver Cancer1
2CompletedTreatmentLocally Advanced Non-Small Cell Lung Cancer1
2CompletedTreatmentLocally Advanced or Metastatic Non Small Cell Lung Cancer Stage IIIb - IV1
2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)46
2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancers2
2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Non-Small Cell Lung Cancer Recurrent / Stage IV Non-Small Cell Lung Cancer1
2CompletedTreatmentLung Cancers30
2CompletedTreatmentMalignancies2
2CompletedTreatmentMalignant Gastrointestinal Stromal Tumor / Sarcomas1
2CompletedTreatmentMalignant Neoplasm of Pancreas11
2CompletedTreatmentMalignant Neoplasm of Stomach8
2CompletedTreatmentMalignant Neoplasm of Stomach / Neoplasms, Esophageal1
2CompletedTreatmentMalignant Neoplasm of Stomach / Peritoneal Carcinomatosis1
2CompletedTreatmentMalignant Pleural Effusions / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer1
2CompletedTreatmentMalignant Solid Tumours1
2CompletedTreatmentMelanoma1
2CompletedTreatmentMetastatic Breast Cancer (MBC)11
2CompletedTreatmentMetastatic Cancers / Prostate Cancer3
2CompletedTreatmentMetastatic Carcinoma / Recurrent Esophageal Squamous Cell Carcinoma1
2CompletedTreatmentMetastatic Hormone Refractory Prostate Cancer3
2CompletedTreatmentMetastatic Hormone Refractory Prostate Cancer / Prostate Cancer1
2CompletedTreatmentMetastatic Melanoma1
2CompletedTreatmentMetastatic Non-Small Cell Lung Cancer1
2CompletedTreatmentMetastatic Pancreatic Carcinoma1
2CompletedTreatmentMetastatic Soft Tissue Sarcoma1
2CompletedTreatmentMetastatic Transitional Cell Cancer of the Urothelial Tract1
2CompletedTreatmentMetastatic or Recurrent Squamous Cell Carcinoma of Head and Neck1
2CompletedTreatmentNasopharyngeal Carcinoma2
2CompletedTreatmentNasopharyngeal Neoplasms2
2CompletedTreatmentNasopharyngeal Squamous Cell Carcinoma / Toxicity Due to Radiotherapy1
2CompletedTreatmentNeoplasms Metastasis / Stomach Neoplasms1
2CompletedTreatmentNeoplasms, Breast11
2CompletedTreatmentNeoplasms, Esophageal / Stomach Neoplasms2
2CompletedTreatmentNeoplasms, Head and Neck4
2CompletedTreatmentNeoplasms, Lung4
2CompletedTreatmentNeoplasms, Ovarian2
2CompletedTreatmentNeoplasms, Ovarian / Uterine Neoplasms1
2CompletedTreatmentNon-Small Cell Lung Cancer (NSCLC, Locally Advanced or Metastatic, Second-line1
2CompletedTreatmentNon-Small Cell Lung Carcinoma (NSCLC)1
2CompletedTreatmentNon-Squamous Non-Small Cell Lung Cancer1
2CompletedTreatmentOesophageal Carcinoma1
2CompletedTreatmentOvarian Carcinoma / Primary Peritoneal Carcinoma1
2CompletedTreatmentOvarian Clear Cell Cystadenocarcinoma / Stage III Ovarian Cancer / Stage IV Ovarian Cancer1
2CompletedTreatmentPain NOS / Prostate Cancer1
2CompletedTreatmentPancreatic Cancer Metastatic1
2CompletedTreatmentPancreatic Cancer Stage IVA1
2CompletedTreatmentPathological Response Rate1
2CompletedTreatmentPrimary Breast Cancer1
2CompletedTreatmentProstate Cancer40
2CompletedTreatmentProstate Cancer / Thromboembolism1
2CompletedTreatmentProstatic Neoplasms9
2CompletedTreatmentRecurrent Breast Cancer / Stage IV Breast Cancer2
2CompletedTreatmentRecurrent Non-Small Cell Lung Carcinoma / Stage IB Non-Small Cell Lung Carcinoma / Stage IIA Non-Small Cell Lung Carcinoma / Stage IIB Non-Small Cell Lung Carcinoma / Stage IIIA Non-Small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer1
2CompletedTreatmentRecurrent Ovarian Epithelial Cancer1
2CompletedTreatmentRecurrent Uterine Corpus Sarcoma / Uterine Carcinosarcoma1
2CompletedTreatmentRecurrent Uterine Corpus Sarcoma / Uterine Corpus Leiomyosarcoma1
2CompletedTreatmentResected Advanced Gastric Cancer1
2CompletedTreatmentSarcomas3
2CompletedTreatmentSoft Tissue Sarcoma (STS)1
2CompletedTreatmentSquamous Cell Carcinoma (SCC)1
2CompletedTreatmentSquamous Cell Carcinoma of the Head and Neck (SCCHN)1
2CompletedTreatmentStomach Neoplasms5
2CompletedTreatmentTherapy, Prostatic Neoplasms1
2CompletedTreatmentTumors, Solid1
2Not Yet RecruitingTreatmentATM Gene Mutation / BRCA1 Gene Mutation / Brca2 Gene Mutation / Castration Levels of Testosterone / Castration-Resistant Prostate Carcinoma / Homologous Recombination Deficiency / Prostate Carcinoma Metastatic in the Bone / PSA Level Greater Than or Equal to Two / PSA Progression / Stage IV Prostate Adenocarcinoma AJCC v71
2Not Yet RecruitingTreatmentBreast Cancer Stage II / Breast Cancer Stage III1
2Not Yet RecruitingTreatmentCancer, Breast1
2Not Yet RecruitingTreatmentCarcinoma, Squamous Cell of Head and Neck1
2Not Yet RecruitingTreatmentCastration Levels of Testosterone / Castration-Resistant Prostate Carcinoma / Metastatic Hormone Refractory Prostate Cancer / PSA Level Greater Than or Equal to Two / Stage IV Prostate Cancer AJCC v81
2Not Yet RecruitingTreatmentCancer treatment / Castration-Resistant Prostate Cancer (CRPC) / Circulating Tumor Cells / Prostate Cancer1
2Not Yet RecruitingTreatmentCastration-Resistant Prostate Cancer (CRPC) / Drugs / Prostate Cancer1
2Not Yet RecruitingTreatmentCastration-Resistant Prostate Cancer (CRPC) / Prostate Cancer1
2Not Yet RecruitingTreatmentEsophageal Cancers1
2Not Yet RecruitingTreatmentLocally Advanced Breast Cancer (LABC)1
2Not Yet RecruitingTreatmentLung Cancer Metastatic / Lung Cancers1
2Not Yet RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)5
2Not Yet RecruitingTreatmentLung Cancers1
2Not Yet RecruitingTreatmentMalignant Neoplasm of Stomach1
2Not Yet RecruitingTreatmentNasopharyngeal Carcinoma1
2Not Yet RecruitingTreatmentNeoplasm Neck1
2Not Yet RecruitingTreatmentNeoplasms1
2Not Yet RecruitingTreatmentTriple Negative Breast Cancer (TNBC)1
2RecruitingPreventionTransitional Cell Carcinoma1
2RecruitingTreatmentAdenocarcinoma of the Lung / Lung Cancers / Non-Squamous Non-Small Cell Lung Cancer (NSCLC) / Squamous Cell Carcinoma of Lung1
2RecruitingTreatmentAdenocarcinoma, Prostate / Prostate Cancer1
2RecruitingTreatmentAdenocarcinomas of the Gastroesophageal Junction / Malignant Neoplasm of Stomach1
2RecruitingTreatmentAdenocarcinomas / Carcinoma, Large Cell / Heregulin / Lung Cancer Non-Small Cell Cancer (NSCLC) / Squamous Cell Carcinoma (SCC)1
2RecruitingTreatmentAdenocarcinomas / Lung Cancer Non-Small Cell Cancer (NSCLC) / Squamous Cell Carcinoma (SCC)1
2RecruitingTreatmentAdvanced Esophageal Squamous Carcinoma1
2RecruitingTreatmentAdvanced Gastric Adenocarcinoma1
2RecruitingTreatmentAnterior Tongue Squamous Cell Carcinoma / Squamous Cell Carcinoma (SCC) / Tongue Neoplasms1
2RecruitingTreatmentAntineoplastic Combined Chemotherapy Protocols1
2RecruitingTreatmentBCT Rate / PCR Rate / Safety1
2RecruitingTreatmentBreast Cancer Invasive Nos / Cancer, Breast1
2RecruitingTreatmentCancer, Breast6
2RecruitingTreatmentCancer, Breast / Lung Cancer Non-Small Cell Cancer (NSCLC) / Malignant Neoplasm of Stomach / Prostate Cancer / Tumors, Solid1
2RecruitingTreatmentCancer, Breast / Neoplasms Metastasis1
2RecruitingTreatmentCancer, Breast / Neoplasms, Breast1
2RecruitingTreatmentCarcinoma, Squamous Cell of Head and Neck / Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck1
2RecruitingTreatmentDocetaxel, Oxaliplatin and Fluorouracil1
2RecruitingTreatmentEndometrial Cancers1
2RecruitingTreatmentGastric Adenocarcinoma1
2RecruitingTreatmentGastric Adenocarcinoma / Gastroesophageal-junction Adenocarcinoma1
2RecruitingTreatmentGastro Esophageal Junction Cancer / Malignant Neoplasm of Stomach1
2RecruitingTreatmentHER-2 Positive Breast Cancer1
2RecruitingTreatmentHead and Neck Carcinoma / Recurrent1
2RecruitingTreatmentHead and Neck Carcinoma / Salivary Gland Tumors1
2RecruitingTreatmentHead and Neck Squamous Cell Carcinoma (HNSCC)1
2RecruitingTreatmentHormone-Resistant Prostate Cancer / Metastatic Hormone Refractory Prostate Cancer / Recurrent Prostate Carcinoma / Stage IV Prostate Cancer1
2RecruitingTreatmentHormone-Resistant Prostate Cancer / Metastatic Hormone Refractory Prostate Cancer / Stage IV Prostate Cancer1
2RecruitingTreatmentHypopharyngeal Cancer / Oropharyngeal Cancers1
2RecruitingTreatmentLocally Advanced Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma / Nasal Cavity and Paranasal Sinus Poorly Differentiated Carcinoma / Paranasal Sinus Neoplasms / Sinonasal Undifferentiated Carcinoma / Squamous Cell Carcinoma (SCC) / Stage II Nasal Cavity and Paranasal Sinus Cancer AJCC v8 / Stage III Nasal Cavity and Paranasal Sinus Cancer AJCC v8 / Stage IVA Nasal Cavity and Paranasal Sinus Cancer AJCC v8 / Stage IVB Nasal Cavity and Paranasal Sinus Cancer AJCC v81
2RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)9
2RecruitingTreatmentLung Cancers1
2RecruitingTreatmentMalignant Neoplasm of Stomach2
2RecruitingTreatmentMetastatic Breast Cancer (MBC)1
2RecruitingTreatmentMetastatic Castration Resistant Prostate Cancer1
2RecruitingTreatmentMetastatic Gastric Cancers1
2RecruitingTreatmentMetastatic Prostatic Adenocarcinoma1
2RecruitingTreatmentNasopharyngeal Carcinoma1
2RecruitingTreatmentNeoplasms, Breast1
2RecruitingTreatmentNeoplasms, Esophageal1
2RecruitingTreatmentNeoplasms, Esophageal / Stomach Neoplasms1
2RecruitingTreatmentNeoplasms, Lung1
2RecruitingTreatmentNon-driver Mutation Advanced Non-Squamous Non Small Cell Lung Cancer / Non-Squamous Non Small Cell Lung Cancer1
2RecruitingTreatmentProstate Cancer7
2RecruitingTreatmentProstate Cancer / Prostate Neoplasms / Prostatic Neoplasms1
2RecruitingTreatmentProstatic Neoplasms1
2RecruitingTreatmentRecurrent Head and Neck Cancer1
2RecruitingTreatmentRecurrent Non-Small Cell Lung Carcinoma / Stage IV Non-Small Cell Lung Cancer1
2RecruitingTreatmentSalivary Gland Cancers / Thyroid Cancers1
2RecruitingTreatmentSarcoma, Osteogenic1
2RecruitingTreatmentSoft Tissue Sarcoma (STS)1
2RecruitingTreatmentSquamous Cell Carcinoma (SCC)1
2RecruitingTreatmentSquamous Cell Carcinoma of Lung1
2RecruitingTreatmentStage II Lymphoepithelioma of the Nasopharynx / Stage II Squamous Cell Carcinoma of the Nasopharynx / Stage III Lymphoepithelioma of the Nasopharynx / Stage III Squamous Cell Carcinoma of the Nasopharynx / Stage IV Lymphoepithelioma of the Nasopharynx / Stage IV Squamous Cell Carcinoma of the Nasopharynx1
2RecruitingTreatmentStage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v6 and v7 / Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v71
2RecruitingTreatmentStage IV Prostate Adenocarcinoma AJCC v71
2RecruitingTreatmentTesticular Cancer1
2RecruitingTreatmentTriple Negative Breast Neoplasms1
2RecruitingTreatmentTriple-Negative Breast Cancer (TNBC)1
2SuspendedTreatmentMetastatic Non-Small Cell Lung Cancer1
2SuspendedTreatmentProstate Cancer1
2TerminatedDiagnosticCancer, Breast1
2TerminatedDiagnosticHead and Neck Carcinoma1
2TerminatedPreventionProstate Cancer1
2TerminatedTreatmentAdenocarcinoma Of Esophagus / Adenocarcinomas of the Gastroesophageal Junction1
2TerminatedTreatmentAdenocarcinoma of the Prostate / Stage IV Prostate Cancer1
2TerminatedTreatmentAdenocarcinoma, Prostate / Hormone-Resistant Prostate Cancer / Metastatic Prostatic Adenocarcinoma / Recurrent Prostate Carcinoma1
2TerminatedTreatmentAdvanced Non-Small Cell Lung Cancer2
2TerminatedTreatmentAdvanced Non-Small Cell Lung Cancer / Non-Small Cell Lung Cancer Stage IIIB / Stage IIIB or IV Non-Small Cell Lung Cancer1
2TerminatedTreatmentBiliary Cancer2
2TerminatedTreatmentBladder Cancers1
2TerminatedTreatmentCancer of Larynx1
2TerminatedTreatmentCancer of the Breast / Cancer, Breast / Neoplasms, Breast1
2TerminatedTreatmentCancer of the Ovary3
2TerminatedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Peritoneal Cavity Cancer1
2TerminatedTreatmentCancer of the Ovary / Primary Peritoneal Cavity Cancer1
2TerminatedTreatmentCancer, Breast16
2TerminatedTreatmentCarcinoma of the Head and Neck1
2TerminatedTreatmentDuctal Carcinoma1
2TerminatedTreatmentEarly-Stage Breast Cancer1
2TerminatedTreatmentEsophageal Cancers2
2TerminatedTreatmentGastric Adenocarcinoma2
2TerminatedTreatmentHead and Neck Carcinoma2
2TerminatedTreatmentHead and Neck Carcinoma / Squamous Carcinoma1
2TerminatedTreatmentHead and Neck Squamous Cell Carcinoma (HNSCC)1
2TerminatedTreatmentHepatocellular,Carcinoma1
2TerminatedTreatmentHormone Refractory Prostate Cancer3
2TerminatedTreatmentHuman Papilloma Virus (HPV) / Squamous Cell Carcinoma of the Head and Neck (SCCHN)1
2TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)15
2TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancers1
2TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / NSCLC (Non-small Cell Lung Carcinoma)1
2TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Non Squamous Cell Lung Cancer1
2TerminatedTreatmentLung Cancers5
2TerminatedTreatmentMalignancies1
2TerminatedTreatmentMalignant Neoplasm of Pancreas3
2TerminatedTreatmentMalignant Neoplasm of Stomach3
2TerminatedTreatmentMediastinal Neoplasms1
2TerminatedTreatmentMetastatic Bladder Cancer / Recurrent Bladder Cancer / Stage III Bladder Cancer / Transitional Cell Carcinoma of the Bladder1
2TerminatedTreatmentMetastatic Breast Cancer (MBC)1
2TerminatedTreatmentMetastatic Hormone Refractory Prostate Cancer1
2TerminatedTreatmentNeoplasms, Breast2
2TerminatedTreatmentNeoplasms, Breast / Relapsed Breast Cancer1
2TerminatedTreatmentNeoplasms, Pancreatic1
2TerminatedTreatmentNeoplasms / Neoplasms, Head and Neck1
2TerminatedTreatmentOesophageal Carcinoma1
2TerminatedTreatmentOral Cancers / Squamous Cell Carcinoma (SCC)1
2TerminatedTreatmentPenile Cancer1
2TerminatedTreatmentProstate Cancer12
2TerminatedTreatmentProstate Cancer Metastatic Castration Resistant1
2TerminatedTreatmentProstatic Neoplasms4
2TerminatedTreatmentRecurrent Non-Small Cell Lung Carcinoma / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer1
2TerminatedTreatmentSquamous Cell Carcinoma of the Head and Neck (SCCHN)1
2Unknown StatusBasic ScienceHormone Refractory Prostate Cancer1
2Unknown StatusDiagnosticLung Cancers1
2Unknown StatusSupportive CareSarcomas1
2Unknown StatusTreatmentAdenocarcinomas of the Gastroesophageal Junction / Gastric Adenocarcinoma1
2Unknown StatusTreatmentAdenocarcinomas of the Gastroesophageal Junction / Gastric Junction Adenocarcinoma1
2Unknown StatusTreatmentBiliary Tract Cancer1
2Unknown StatusTreatmentBladder Cancers / Transitional Cell Cancer of the Renal Pelvis and Ureter1
2Unknown StatusTreatmentBreast Cancer Stage II / Breast Cancer Stage III1
2Unknown StatusTreatmentBreast Diseases / Cancer, Breast / Neoplasms / Neoplasms by Site1
2Unknown StatusTreatmentCancer of the Ovary / Endometrial Cancers / Fallopian Tube Cancer / Primary Peritoneal Cavity Cancer1
2Unknown StatusTreatmentCancer, Breast11
2Unknown StatusTreatmentCarcinoma, Large Cell / Lung Cancer Non-Small Cell Cancer (NSCLC) / Squamous Carcinoma1
2Unknown StatusTreatmentDrug Therapy / Genes, EGFR / Neoplasms, Lung / Non-Small Cell Lung Carcinoma (NSCLC)1
2Unknown StatusTreatmentEsophageal Cancers / Malignant Neoplasm of Stomach1
2Unknown StatusTreatmentGastroesophageal Junction Cancer / Malignant Neoplasm of Stomach1
2Unknown StatusTreatmentHead and Neck Carcinoma2
2Unknown StatusTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)12
2Unknown StatusTreatmentLung Cancer Small Cell Lung Cancer (SCLC)1
2Unknown StatusTreatmentLung Cancers8
2Unknown StatusTreatmentMalignant Neoplasm of Nasopharynx1
2Unknown StatusTreatmentMalignant Neoplasm of Pancreas1
2Unknown StatusTreatmentMalignant Neoplasm of Stomach4
2Unknown StatusTreatmentMetastatic Breast Cancer (MBC) / Recurrent Breast Cancer1
2Unknown StatusTreatmentNasopharyngeal Carcinoma4
2Unknown StatusTreatmentNeoplasms, Breast1
2Unknown StatusTreatmentPain NOS / Prostate Cancer1
2Unknown StatusTreatmentPancreas Neoplasms1
2Unknown StatusTreatmentProstate Cancer2
2Unknown StatusTreatmentProstatic Neoplasms1
2Unknown StatusTreatmentSarcomas1
2Unknown StatusTreatmentSoft Tissue Sarcoma (STS)1
2Unknown StatusTreatmentSquamous Cell Carcinoma of Lung1
2Unknown StatusTreatmentSquamous Cell Carcinoma of the Head / Squamous Cell Carcinoma of the Neck1
2Unknown StatusTreatmentStomach Neoplasms3
2WithdrawnDiagnosticStage IIIA Non-Small Cell Lung Cancer1
2WithdrawnTreatmentAdenocarcinoma of the Prostate / Prostate Cancer / Stage I Prostate Cancer / Stage II Prostate Cancer1
2WithdrawnTreatmentCancer, Breast6
2WithdrawnTreatmentCarcinoma of Unknown Primary1
2WithdrawnTreatmentHead and Neck Carcinoma1
2WithdrawnTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)3
2WithdrawnTreatmentLung Cancer Small Cell Lung Cancer (SCLC)1
2WithdrawnTreatmentNeoplasms, Breast2
2WithdrawnTreatmentProstate Cancer5
2WithdrawnTreatmentStage IV Non-Small Cell Lung Cancer1
2WithdrawnTreatmentTransitional Cell Carcinoma2
2WithdrawnTreatmentTumors, Solid1
2, 3Active Not RecruitingTreatmentCCND1 Gene Amplification / CCND2 Gene Amplification / CCND3 Gene Amplification / CDK4 Gene Amplification / Recurrent Squamous Cell Lung Carcinoma / Stage IV Squamous Cell Lung Carcinoma / Stage IV Squamous Cell Lung Carcinoma AJCC v71
2, 3Active Not RecruitingTreatmentFGFR1 Gene Amplification / FGFR1 Gene Mutation / FGFR2 Gene Amplification / FGFR2 Gene Mutation / FGFR3 Gene Amplification / FGFR3 Gene Mutation / Recurrent Squamous Cell Lung Carcinoma / Stage IV Squamous Cell Lung Carcinoma / Stage IV Squamous Cell Lung Carcinoma AJCC v71
2, 3Active Not RecruitingTreatmentGastric Adenocarcinoma1
2, 3Active Not RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
2, 3Active Not RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Non-Small Cell Lung Cancer Recurrent / Progression of Non-small Cell Lung Cancer1
2, 3Active Not RecruitingTreatmentMalignant Neoplasm of Stomach1
2, 3Active Not RecruitingTreatmentRecurrent Squamous Cell Lung Carcinoma / Stage IV Squamous Cell Lung Carcinoma / Stage IV Squamous Cell Lung Carcinoma AJCC v71
2, 3Active Not RecruitingTreatmentStage III Squamous Cell Carcinoma of the Hypopharynx / Stage III Squamous Cell Carcinoma of the Larynx / Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage III Squamous Cell Carcinoma of the Oropharynx / Stage III Verrucous Carcinoma of the Larynx / Stage III Verrucous Carcinoma of the Oral Cavity / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IVA Squamous Cell Carcinoma of the Larynx / Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IVA Squamous Cell Carcinoma of the Oropharynx / Stage IVA Verrucous Carcinoma of the Larynx / Stage IVA Verrucous Carcinoma of the Oral Cavity / Stage IVB Squamous Cell Carcinoma of the Larynx / Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IVB Squamous Cell Carcinoma of the Oropharynx / Stage IVB Verrucous Carcinoma of the Larynx / Stage IVB Verrucous Carcinoma of the Oral Cavity / Tongue Cancer1
2, 3CompletedSupportive CareChemotherapy Induced Neutropenia1
2, 3CompletedTreatmentCancer, Breast1
2, 3CompletedTreatmentCisplatin Adverse Reaction / Upper GI Cancer1
2, 3CompletedTreatmentNeoplasm Recurrence, Local / Neoplasms Metastasis / Neoplasms, Head and Neck1
2, 3CompletedTreatmentProgression Free Survival1
2, 3Not Yet RecruitingNot AvailableNasopharyngeal Carcinoma1
2, 3Not Yet RecruitingTreatmentCancer treatment / Cancer, Breast / Endocrine Breast Diseases1
2, 3Not Yet RecruitingTreatmentCancer, Breast / Neoadjuvant Chemotherapy / Pathological Complete Response1
2, 3Not Yet RecruitingTreatmentStage III Breast Cancer1
2, 3RecruitingScreeningLung Cancer Non-Small Cell Cancer (NSCLC)1
2, 3RecruitingSupportive CareChemotherapy Induced Neutropenia1
2, 3RecruitingTreatmentCancer, Breast1
2, 3RecruitingTreatmentCancer, Breast / Triple Negative Breast Cancer (TNBC)1
2, 3RecruitingTreatmentGastric Carcinoma1
2, 3RecruitingTreatmentGastroesophageal Junction Cancer / Malignant Neoplasm of Stomach1
2, 3RecruitingTreatmentHead and Neck Squamous Cell Carcinoma (HNSCC)1
2, 3RecruitingTreatmentNon Small Cell Lung Cancer Stage IIIB / Non-Small Cell Carcinoma of Lung, TNM Stage 41
2, 3RecruitingTreatmentProstate Cancer1
2, 3RecruitingTreatmentRecurrent Squamous Cell Lung Carcinoma / Stage IV Squamous Cell Lung Carcinoma / Stage IV Squamous Cell Lung Carcinoma AJCC v71
2, 3RecruitingTreatmentStage I Prostate Adenocarcinoma / Stage II Prostate Adenocarcinoma / Stage III Prostate Adenocarcinoma1
2, 3SuspendedTreatmentMetastatic Breast Cancer (MBC)1
2, 3TerminatedTreatmentActivating EGFR Mutation / Lung Cancer Non-Small Cell Cancer (NSCLC) / Non-squamous Non-small Cell Lung Cancer Stage II / Non-squamous Non-small Cell Lung Cancer Stage IIIA / Non-squamous Non-small Cell Lung Cancer Stage IIIB1
2, 3TerminatedTreatmentAdvanced Non-Small Cell Lung Cancer / Metastatic Non-Small Cell Lung Cancer / Non-Small Cell Lung Cancer Stage IIIB1
2, 3TerminatedTreatmentProstate Cancer1
2, 3Unknown StatusTreatmentLobaplatin and Gemcitabine in Combination, Second-line Treatments on Advanced Osteosarcoma1
2, 3Unknown StatusTreatmentLung Cancers1
2, 3Unknown StatusTreatmentPancreatic Cancer Stage II / Pancreatic Cancer Stage III1
2, 3Unknown StatusTreatmentProstate Cancer1
3Active Not RecruitingNot AvailableCancer, Breast1
3Active Not RecruitingOtherMetastatic Castration Resistant Prostate Cancer1
3Active Not RecruitingPreventionLung Cancer Non-Small Cell Cancer (NSCLC)1
3Active Not RecruitingTreatmentAdenocarcinoma, Mucinous / Carcinoma, Undifferentiated / Clear Cell Adenocarcinoma / Fallopian Tube Clear Cell Adenocarcinoma / Fallopian Tube Endometrioid Adenocarcinoma / Fallopian Tube Mucinous Adenocarcinoma / Fallopian Tube Serous Adenocarcinoma / Fallopian Tube Undifferentiated Carcinoma / Malignant Ovarian Mixed Epithelial Tumor / Ovarian Brenner Tumor / Ovarian Clear Cell Adenocarcinofibroma / Ovarian Endometrioid Adenocarcinoma / Ovarian Seromucinous Carcinoma / Ovarian Serous Adenocarcinoma / Ovarian Undifferentiated Carcinoma / Primary Peritoneal Serous Adenocarcinoma / Recurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma / Undifferentiated Fallopian Tube Carcinoma / Undifferentiated Ovarian Carcinoma1
3Active Not RecruitingTreatmentAdenocarcinomas of the Gastroesophageal Junction / Esophageal Cancers1
3Active Not RecruitingTreatmentBladder Cancers1
3Active Not RecruitingTreatmentCancer, Breast20
3Active Not RecruitingTreatmentCancer, Breast / Neoplasms, Breast1
3Active Not RecruitingTreatmentEsophagogastric Junction Carcinoma / Oesophageal Carcinoma1
3Active Not RecruitingTreatmentEstrogen Receptor Negative / Estrogen Receptor Positive / HER2/Neu Positive / Progesterone Receptor Negative / Progesterone Receptor Positive / Recurrent Breast Carcinoma / Stage IA Breast Cancer / Stage IA Breast Cancer AJCC v7 / Stage IB Breast Cancer / Stage IB Breast Cancer AJCC v7 / Stage IIA Breast Cancer / Stage IIA Breast Cancer AJCC v6 and v7 / Stage IIB Breast Cancer / Stage IIB Breast Cancer AJCC v6 and v7 / Stage IIIA Breast Cancer / Stage IIIA Breast Cancer AJCC v7 / Stage IIIC Breast Cancer / Stage IIIC Breast Cancer AJCC v71
3Active Not RecruitingTreatmentEstrogen Receptor Positive / HER2/Neu Positive / Progesterone Receptor Positive / Stage IB Breast Cancer / Stage IB Breast Cancer AJCC v7 / Stage II Breast Cancer / Stage IIA Breast Cancer / Stage IIA Breast Cancer AJCC v6 and v7 / Stage IIB Breast Cancer / Stage IIB Breast Cancer AJCC v6 and v7 / Stage IIIA Breast Cancer / Stage IIIA Breast Cancer AJCC v7 / Stage IIIB Breast Cancer / Stage IIIB Breast Cancer AJCC v7 / Stage IIIC Breast Cancer / Stage IIIC Breast Cancer AJCC v71
3Active Not RecruitingTreatmentHER2 Positive Breast Cancers1
3Active Not RecruitingTreatmentHead and Neck Squamous Cell Cancer1
3Active Not RecruitingTreatmentHer2 Non-overexpressing / Primary Breast Cancer1
3Active Not RecruitingTreatmentLocally Advanced or Metastatic Non Small Cell Lung Cancer Stage IIIb - IV1
3Active Not RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)7
3Active Not RecruitingTreatmentMalignant Neoplasm of Stomach1
3Active Not RecruitingTreatmentMetastatic Breast Cancer (MBC)1
3Active Not RecruitingTreatmentMetastatic Castrate Resistant Prostate Cancer1
3Active Not RecruitingTreatmentMetastatic Castration Resistant Prostate Cancer1
3Active Not RecruitingTreatmentMetastatic Hormone-sensitive Prostate Cancer1
3Active Not RecruitingTreatmentNasopharyngeal Carcinoma1
3Active Not RecruitingTreatmentNasopharyngeal Neoplasms1
3Active Not RecruitingTreatmentNon-Squamous Cell Non-small Cell Lung Cancer1
3Active Not RecruitingTreatmentNon-Squamous Non-Small Cell Lung Cancer2
3Active Not RecruitingTreatmentProstate Cancer5
3Active Not RecruitingTreatmentProstatic Neoplasms2
3Active Not RecruitingTreatmentRecurrent Hypopharyngeal Squamous Cell Carcinoma / Recurrent Laryngeal Squamous Cell Carcinoma / Recurrent Laryngeal Verrucous Carcinoma / Recurrent Lip and Oral Cavity Squamous Cell Carcinoma / Recurrent Metastatic Squamous Cell Carcinoma in the Neck With Occult Primary / Recurrent Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma / Recurrent Oral Cavity Verrucous Carcinoma / Recurrent Oropharyngeal Squamous Cell Carcinoma / Recurrent Salivary Gland Carcinoma / Salivary Gland Squamous Cell Carcinoma / Squamous Cell Carcinoma Metastatic in the Neck With Occult Primary / Stage IV Hypopharyngeal Squamous Cell Carcinoma / Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IV Major Salivary Gland Cancer AJCC v7 / Stage IV Major Salivary Gland Carcinoma / Stage IVA Laryngeal Squamous Cell Carcinoma / Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7 / Stage IVA Laryngeal Verrucous Carcinoma / Stage IVA Laryngeal Verrucous Carcinoma AJCC v7 / Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma / Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage IVA Major Salivary Gland Cancer AJCC v7 / Stage IVA Major Salivary Gland Carcinoma / Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma / Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7 / Stage IVA Oral Cavity Cancer AJCC v6 and v7 / Stage IVA Oral Cavity Verrucous Carcinoma / Stage IVA Oropharyngeal Squamous Cell Carcinoma / Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IVB Laryngeal Squamous Cell Carcinoma / Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7 / Stage IVB Laryngeal Verrucous Carcinoma / Stage IVB Laryngeal Verrucous Carcinoma AJCC v7 / Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma / Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage IVB Major Salivary Gland Cancer AJCC v7 / Stage IVB Major Salivary Gland Carcinoma / Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma / Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7 / Stage IVB Oral Cavity Cancer AJCC v6 and v7 / Stage IVB Oral Cavity Verrucous Carcinoma / Stage IVB Oropharyngeal Squamous Cell Carcinoma / Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IVC Laryngeal Squamous Cell Carcinoma / Stage IVC Laryngeal Squamous Cell Carcinoma AJCC v7 / Stage IVC Laryngeal Verrucous Carcinoma / Stage IVC Laryngeal Verrucous Carcinoma AJCC v7 / Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma / Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage IVC Major Salivary Gland Cancer AJCC v7 / Stage IVC Major Salivary Gland Carcinoma / Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma / Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7 / Stage IVC Oral Cavity Cancer AJCC v6 and v7 / Stage IVC Oral Cavity Verrucous Carcinoma / Stage IVC Oropharyngeal Squamous Cell Carcinoma / Stage IVC Oropharyngeal Squamous Cell Carcinoma AJCC v7 / Tongue Carcinoma / Untreated Metastatic Squamous Cell Carcinoma to Neck With Occult Primary1
3Active Not RecruitingTreatmentSquamous Cell Carcinoma of the Head and Neck (SCCHN)1
3Active Not RecruitingTreatmentSquamous Cell Non-small Cell Lung Cancer1
3Active Not RecruitingTreatmentStage I Uterine Sarcoma / Stage I Uterine Sarcoma AJCC v7 / Uterine Corpus Leiomyosarcoma1
3Active Not RecruitingTreatmentStage IB Non-Small Cell Lung Carcinoma / Stage IB Non-Small Cell Lung Carcinoma AJCC v7 / Stage IIA Non-Small Cell Lung Carcinoma / Stage IIA Non-Small Cell Lung Carcinoma AJCC v7 / Stage IIB Non-Small Cell Lung Carcinoma / Stage IIB Non-Small Cell Lung Carcinoma AJCC v7 / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIA Non-Small Cell Lung Cancer AJCC v71
3Active Not RecruitingTreatmentTransitional Cell Carcinoma1
3Active Not RecruitingTreatmentUrothelial Cancer1
3CompletedNot AvailableEsophageal Cancers1
3CompletedNot AvailableLung Cancer Non-Small Cell Cancer (NSCLC)1
3CompletedPreventionMalignancies1
3CompletedPreventionNon Small Cell Lung Carcinoma (NSCLC)1
3CompletedSupportive CareAnorexic / Cachexia / Lung Cancers / Tiredness1
3CompletedSupportive CareCancer, Breast1
3CompletedSupportive CareCancer, Breast / Chemotherapy Induced Neutropenia1
3CompletedSupportive CareChemotherapy Induced Neutropenia1
3CompletedTreatmentAdenocarcinoma of the Lung / Bronchoalveolar Cell Lung Cancer / Large Cell Lung Cancer / Squamous Cell Carcinoma of Lung / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIb Non-small Cell Lung Cancer1
3CompletedTreatmentAdenocarcinoma of the Prostate / Hormone-Resistant Prostate Cancer / Recurrent Prostate Cancer / Stage IV Prostate Cancer1
3CompletedTreatmentAdenocarcinoma of the Stomach / Adenocarcinomas of the Gastroesophageal Junction1
3CompletedTreatmentAdenocarcinomas of the Gastroesophageal Junction / Esophageal Cancers / Malignant Neoplasm of Stomach / Nausea and vomiting / Pain NOS1
3CompletedTreatmentAnaplastic Lymphoma Kinase-positive Non-small Cell Lung Cancer / Lung Cancer Non-Small Cell Cancer (NSCLC)1
3CompletedTreatmentCancer of the Breast / Cancer, Breast / Neoplasms, Breast1
3CompletedTreatmentCancer of the Larynx / Cancer of the Nasal Cavity / Cancer of the Oral Cavity / Cancer of the Pharynx / Paranasal Sinus Neoplasms1
3CompletedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Peritoneal Cavity Cancer1
3CompletedTreatmentCancer of the Ovary / Primary Peritoneal Cavity Cancer1
3CompletedTreatmentCancer, Breast41
3CompletedTreatmentCancer, Breast / Neoplasms, Breast1
3CompletedTreatmentCancer, Breast / Stage IV Breast Cancer1
3CompletedTreatmentCarcinoma NOS / Non Small Cell Lung1
3CompletedTreatmentHead and Neck Carcinoma2
3CompletedTreatmentHypopharynx Cancer / Laryngeal Cancer1
3CompletedTreatmentIll-defined Sites / Supportive1
3CompletedTreatmentInflammatory carcinoma of the breast1
3CompletedTreatmentInoperable Gastric Cancer1
3CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)18
3CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancers1
3CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Non-Small-Cell Lung Cancer Metastatic / Non-Small-Cell Lung Cancer Stage IIIB / Non-Small-Cell Lung Cancer Stage IV1
3CompletedTreatmentLung Cancers5
3CompletedTreatmentMalignancies1
3CompletedTreatmentMalignant Neoplasm of Female Breast1
3CompletedTreatmentMalignant Neoplasm of Stomach1
3CompletedTreatmentMetastatic Breast Cancer (MBC)2
3CompletedTreatmentMetastatic Cancers / Prostate Cancer1
3CompletedTreatmentMetastatic, Locally Advanced or Unresectable Soft Tissue Sarcoma1
3CompletedTreatmentNeoplasms Metastasis / Prostatic Neoplasms1
3CompletedTreatmentNeoplasms, Breast6
3CompletedTreatmentNeoplasms, Head and Neck1
3CompletedTreatmentNeoplasms, Lung2
3CompletedTreatmentNon-Squamous Non-Small Cell Lung Cancer1
3CompletedTreatmentProstate Cancer9
3CompletedTreatmentProstatic Neoplasms2
3CompletedTreatmentSoft Tissue Sarcoma (STS)1
3CompletedTreatmentSquamous Cell Carcinoma (SCC)1
3CompletedTreatmentStage I Breast Carcinoma1
3CompletedTreatmentStomach Neoplasms1
3Enrolling by InvitationTreatmentMalignancies1
3Enrolling by InvitationTreatmentMalignant Neoplasm of Stomach1
3Not Yet RecruitingOtherNeoplasms, Breast1
3Not Yet RecruitingTreatmentChemotherapy Effect / Susceptibility, Genetic1
3Not Yet RecruitingTreatmentNasopharyngeal Carcinoma3
3Not Yet RecruitingTreatmentNon-Small-Cell Lung1
3RecruitingTreatmentAdenocarcinomas of the Esophagogastric Junction / Esophageal Adenocarcinoma (UICC TNM7)1
3RecruitingTreatmentBladder Cancers / Ureteral Cancer / Urothelial Cancer1
3RecruitingTreatmentBreast Cancer Model / Cancer, Breast / Effects of Chemotherapy1
3RecruitingTreatmentBreastcancer / Neutropenias1
3RecruitingTreatmentCancer, Breast3
3RecruitingTreatmentCancer, Breast / Metastasis1
3RecruitingTreatmentCarcinoma, Bronchogenic / Chronic Lung Diseases / Neoplasm, Bronchial / Neoplasms / Neoplasms, Lung / Respiratory Tract Diseases / Respiratory Tract Neoplasms / Stage IV, NSCLC / Thoracic Neoplasms1
3RecruitingTreatmentCastration Levels of Testosterone / Metastatic Prostatic Adenocarcinoma / Stage IV Prostate Cancer AJCC v8 / Stage IVA Prostate Cancer AJCC v8 / Stage IVB Prostate Cancer AJCC v81
3RecruitingTreatmentCervical Cancers1
3RecruitingTreatmentChemotherapeutic Toxicity / Chemotherapy Effect / Stomach Neoplasms1
3RecruitingTreatmentChemotherapy Effects / Esophagus Cancer1
3RecruitingTreatmentEsophageal Cancers1
3RecruitingTreatmentEsophageal Cancers / Malignant Neoplasm of Esophagus / Squamous Cell Carcinoma of Esophagus1
3RecruitingTreatmentGastric Adenocarcinoma1
3RecruitingTreatmentGastric Cancer, Adjuvant Chemotherapy, XO1
3RecruitingTreatmentGastroesophageal Junction Cancer / Malignant Neoplasm of Stomach1
3RecruitingTreatmentHER2-positive Locally Advanced or Metastatic Breast Cancer1
3RecruitingTreatmentHead and Neck Squamous Cell Carcinoma (HNSCC)1
3RecruitingTreatmentHer2-Positive Breast Cancer1
3RecruitingTreatmentHuman Papillomavirus Positive / Oropharyngeal Squamous Cell Carcinoma1
3RecruitingTreatmentLocally Advanced Nasopharyngeal Carcinoma1
3RecruitingTreatmentLocally Advanced Unresectable Gastric Cancer / Metastatic Gastric Cancers1
3RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)6
3RecruitingTreatmentMalignant Neoplasm of Stomach1
3RecruitingTreatmentMetastatic Breast Cancer (MBC)1
3RecruitingTreatmentMetastatic Hormone Refractory Prostate Cancer / Prostate Cancer Adenocarcinoma Metastatic1
3RecruitingTreatmentNasopharyngeal Carcinoma3
3RecruitingTreatmentNon-Small Cell Lung Carcinoma (NSCLC)1
3RecruitingTreatmentNon-squamous Cell NSCLC / Squamous Cell Lung Carcinoma1
3RecruitingTreatmentOesophageal Carcinoma1
3RecruitingTreatmentOesophago-gastric carcinoma1
3RecruitingTreatmentOligo-metastatic Stage IV Non-small Cell Lung Cancer / Oligo-metastatic Stage IV Non-small Cell Lung Cancer(NSCLC)1
3RecruitingTreatmentOropharynx Cancers1
3RecruitingTreatmentStage I Breast Carcinoma1
3RecruitingTreatmentTriple Negative Breast Cancer (TNBC)1
3RecruitingTreatmentUrothelial Cancer1
3TerminatedTreatmentAdvanced Non-Small Cell Lung Cancer1
3TerminatedTreatmentAdvanced Non-Small Cell Lung Cancer / Metastatic Non-Small Cell Lung Cancer / Non-Small Cell Lung Cancer Stage IIIB / Non-Small-Cell Lung Adenocarcinoma1
3TerminatedTreatmentCancer, Breast3
3TerminatedTreatmentCastrate-resistant Prostate Cancer (CRPC) / Hormone Refractory Prostate Cancer1
3TerminatedTreatmentHead and Neck Carcinoma2
3TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)3
3TerminatedTreatmentLung Cancers2
3TerminatedTreatmentMetastatic Head and Neck Cancer / Recurrent Head and Neck Cancer1
3TerminatedTreatmentNon Small Cell Lung Carcinoma (NSCLC)1
3TerminatedTreatmentNon-Small Cell Lung Carcinoma (NSCLC)2
3TerminatedTreatmentProstate Cancer5
3TerminatedTreatmentProstatic Neoplasms2
3TerminatedTreatmentRecurrent Uterine Corpus Sarcoma / Stage IIIA Uterine Sarcoma / Stage IIIB Uterine Sarcoma / Stage IIIC Uterine Sarcoma / Stage IVA Uterine Sarcoma / Stage IVB Uterine Sarcoma / Uterine Corpus Leiomyosarcoma1
3Unknown StatusDiagnosticCancer, Breast1
3Unknown StatusScreeningNeoplasms, Lung1
3Unknown StatusTreatmentAdenocarcinoma of the Prostate1
3Unknown StatusTreatmentAdvanced Prostate Cancer1
3Unknown StatusTreatmentCancer, Breast6
3Unknown StatusTreatmentCancer, Breast / Cardiac Toxicity / Perioperative/Postoperative Complications1
3Unknown StatusTreatmentCancer treatment / Cancer, Breast1
3Unknown StatusTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
3Unknown StatusTreatmentLung Cancers3
3Unknown StatusTreatmentPain NOS / Prostate Cancer1
3Unknown StatusTreatmentProstate Cancer2
3WithdrawnTreatmentAdult Solid Tumor / Cancer, Breast / Head and Neck Carcinoma / Kidney and Urinary Cancer / Male Reproductive Cancer / Thorax and Respiratory Cancer1
4Active Not RecruitingTreatmentCancer, Breast / Malignant Neoplasm of Female Breast1
4Active Not RecruitingTreatmentNeoplasms, Therapy-Associated1
4CompletedNot AvailableLung Cancer Non-Small Cell Cancer (NSCLC) / Squamous Cell Carcinoma of the Head and Neck (SCCHN)1
4CompletedTreatmentCancer, Breast4
4CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)2
4CompletedTreatmentNeoplasms, Head and Neck1
4CompletedTreatmentProstatic Neoplasms1
4CompletedTreatmentSquamous Cell Carcinoma (SCC)1
4RecruitingScreeningLiver Injury, Drug-Induced1
4RecruitingTreatmentAdenocarcinomas / EGFR Positive Non-small Cell Lung Cancer1
4RecruitingTreatmentAdvanced Lung Squamous Carcinoma1
4RecruitingTreatmentCancer, Breast3
4RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
4RecruitingTreatmentNeoplasms, Breast1
4RecruitingTreatmentPatients With Head and Neck Cancer (ORL)1
4TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
4WithdrawnTreatmentCancer, Breast1
Not AvailableActive Not RecruitingNot AvailableMalnutrition / Nasopharyngeal Carcinoma2
Not AvailableActive Not RecruitingNot AvailableMetastatic Cancers / Prostate Cancer1
Not AvailableActive Not RecruitingTreatmentLung Cancers1
Not AvailableActive Not RecruitingTreatmentNasopharyngeal Neoplasms1
Not AvailableCompletedNot AvailableAssociations Between Genetic Data and Docetaxel Toxicity / CYP3A Phenotyping / CYP3A5 and MDR1 Genotyping / Docetaxel Toxicity1
Not AvailableCompletedNot AvailableCancer, Breast2
Not AvailableCompletedNot AvailableCancer, Breast / Chemotherapeutic Agent Toxicity / Cognitive/Functional Effects / Long-Term Effects Secondary to Cancer Therapy in Adults / Neurologic toxicity / Psychosocial Effects of Cancer and Its Treatment / Tiredness1
Not AvailableCompletedNot AvailableMalignant Neoplasm of Colon / Metastatic Breast Cancer (MBC) / Metastatic Breast Cancer, Colon Cancer1
Not AvailableCompletedNot AvailableMetastatic Cancers / Prostate Cancer1
Not AvailableCompletedNot AvailableMetastatic Castration Resistant Prostate Cancer1
Not AvailableCompletedNot AvailableNeoplasms1
Not AvailableCompletedNot AvailableNeoplasms, Ovarian1
Not AvailableCompletedDiagnosticCancer, Breast1
Not AvailableCompletedHealth Services ResearchLung Cancer Non-Small Cell Cancer (NSCLC)1
Not AvailableCompletedTreatmentCancer, Breast6
Not AvailableCompletedTreatmentHypermethylation / Lung Cancers / Non Small Cell Lung Carcinoma (NSCLC)1
Not AvailableCompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
Not AvailableCompletedTreatmentSquamous Cell Carcinoma of Esophagus1
Not AvailableNot Yet RecruitingNot AvailableObservational / Prospective1
Not AvailableNot Yet RecruitingNot AvailableProstate Cancer, Castration Resistant1
Not AvailableNot Yet RecruitingTreatmentNon-Squamous Non-Small Cell Lung Cancer1
Not AvailableRecruitingNot AvailableBiliary Tract Cancer / Colo-rectal Cancer / Esophageal Cancers / Gall Bladder Cancer / Liver Cancer / Malignant Neoplasm of Pancreas / Malignant Neoplasm of Stomach1
Not AvailableRecruitingNot AvailableProstate Cancer2
Not AvailableRecruitingHealth Services ResearchCancer, Breast1
Not AvailableRecruitingTreatmentAdenocarcinomas1
Not AvailableRecruitingTreatmentBreast Cancer Nos Premenopausal1
Not AvailableRecruitingTreatmentCastration Levels of Testosterone / Castration-Resistant Prostate Carcinoma / Hormone-Resistant Prostate Cancer / Metastatic Hormone Refractory Prostate Cancer / Prostate Carcinoma Metastatic in the Bone / PSA Progression / Recurrent Prostate Carcinoma / Stage IV Prostate Cancer1
Not AvailableRecruitingTreatmentDrug-Related Side Effects and Adverse Reactions1
Not AvailableSuspendedNot AvailableCancer, Breast / Neoplasms, Breast1
Not AvailableTerminatedTreatmentEsophageal Cancers / Malignant Neoplasm of Stomach1
Not AvailableTerminatedTreatmentMalignant Neoplasm of Pancreas1
Not AvailableTerminatedTreatmentNon-Small Cell Lung Cancer Recurrent / Stage IV Non-Small Cell Lung Cancer1
Not AvailableUnknown StatusNot AvailableHormone Refractory Prostate Cancer1
Not AvailableUnknown StatusNot AvailableProstate Cancer1
Not AvailableUnknown StatusTreatmentCancer, Breast1
Not AvailableUnknown StatusTreatmentProstate Cancer1
Not AvailableUnknown StatusTreatmentStage IA Uterine Sarcoma / Stage IB Uterine Sarcoma / Stage IC Uterine Sarcoma / Stage IIA Uterine Sarcoma / Stage IIB Uterine Sarcoma / Stage IIIA Uterine Sarcoma / Stage IIIB Uterine Sarcoma / Stage IIIC Uterine Sarcoma / Stage IVA Uterine Sarcoma / Stage IVB Uterine Sarcoma / Uterine Corpus Leiomyosarcoma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Sanofi-Aventis Inc.
Dosage forms
FormRouteStrength
Kit20 mg/0.8mL
Kit80 mg/4mL
InjectionIntravenous160 mg/8mL
InjectionIntravenous80 mg/4mL
Injection, solutionIntravenous10 mg/1mL
Injection, solutionIntravenous20 mg/1mL
Injection, solutionIntravenous80 mg/4mL
Injection, solution, concentrateIntravenous20 mg/2mL
Injection, solution, concentrateIntravenous200 mg/20mL
Injection, solution, concentrateIntravenous80 mg/8mL
Kit40 mg/1mL
SolutionIntravenous20 mg/1mL
Injection, solutionIntravenous160 mg/16mL
Injection, solutionIntravenous20 mg/2mL
Injection, solutionIntravenous80 mg/8mL
SolutionIntravenous10 mg
Injection, solution, concentrateIntravenous120 mg/6ml
Injection, solution, concentrateIntravenous160 mg/8ml
Injection, solution, concentrateIntravenous180 mg/9ml
Injection, solution, concentrateIntravenous20 mg/1ml
Injection, solution, concentrateIntravenous200 mg/10ml
Injection, solution, concentrateIntravenous80 mg/4ml
InjectionIntravenous20 mg/1mL
Injection, solution, concentrateIntravenous20 mg
Injection, solution, concentrateIntravenous80 mg
Kit; solutionIntravenous20 mg
Kit; solutionIntravenous80 mg
SolutionIntravenous160 mg
Injection, solution, concentrateIntravenous140 mg/7ml
Injection, solution, concentrateIntravenous20 mg/0.5ml
Injection, solution, concentrateIntravenous40 mg/1mL
Injection, solution, concentrateIntravenous80 mg/2ml
SolutionIntravenous20 mg
SolutionIntravenous80 mg
Prices
Unit descriptionCostUnit
Taxotere 20 mg/0.5 ml vial477.37USD vial
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5438072No1994-05-222014-05-22Us
US4814470No1993-05-142010-05-14Us
CA2150576No2005-06-212013-11-26Canada
CA2149055No2003-01-072013-11-08Canada
US8940786No2013-09-302033-09-30Us
US9308195No2013-09-302033-09-30Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)232 °CPhysProp
water solubilityInsoluble FDA label
logP2.4Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0127 mg/mLALOGPS
logP2.59ALOGPS
logP2.92ChemAxon
logS-4.8ALOGPS
pKa (Strongest Acidic)10.96ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count10ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area224.45 Å2ChemAxon
Rotatable Bond Count13ChemAxon
Refractivity203.9 m3·mol-1ChemAxon
Polarizability82.06 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9743
Blood Brain Barrier-0.9659
Caco-2 permeable-0.8252
P-glycoprotein substrateSubstrate0.8259
P-glycoprotein inhibitor IInhibitor0.644
P-glycoprotein inhibitor IINon-inhibitor0.5139
Renal organic cation transporterNon-inhibitor0.9393
CYP450 2C9 substrateNon-substrate0.816
CYP450 2D6 substrateNon-substrate0.8828
CYP450 3A4 substrateSubstrate0.7119
CYP450 1A2 substrateNon-inhibitor0.8299
CYP450 2C9 inhibitorNon-inhibitor0.8737
CYP450 2D6 inhibitorNon-inhibitor0.8972
CYP450 2C19 inhibitorNon-inhibitor0.8421
CYP450 3A4 inhibitorNon-inhibitor0.7324
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8776
Ames testNon AMES toxic0.8382
CarcinogenicityNon-carcinogens0.9133
BiodegradationNot ready biodegradable0.9934
Rat acute toxicity2.5741 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9907
hERG inhibition (predictor II)Non-inhibitor0.7905
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as taxanes and derivatives. These are diterpenoids with a structure based either on the taxane skeleton, or a derivative thereof. In term of phytochemistry, several derivatives of the taxane skeleton exist: 2(3->20)-abeotaxane, 3,11-cyclotaxane, 11(15->1),11(10->9)-abeotaxane, 3,8-seco-taxane, and 11(15->1)-abeotaxane, among others. More complex skeletons have been found recently, which include the taxane-derived [3.3.3] propellane ring system.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Prenol lipids
Sub Class
Diterpenoids
Direct Parent
Taxanes and derivatives
Alternative Parents
Benzoic acid esters / Tricarboxylic acids and derivatives / Benzoyl derivatives / Fatty acid esters / Monosaccharides / Tertiary alcohols / Carbamate esters / Secondary alcohols / Oxetanes / Carboxylic acid esters
show 10 more
Substituents
Taxane diterpenoid / Benzoate ester / Benzoic acid or derivatives / Tricarboxylic acid or derivatives / Benzoyl / Fatty acid ester / Monocyclic benzene moiety / Fatty acyl / Monosaccharide / Benzenoid
show 24 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
tetracyclic diterpenoid (CHEBI:4672)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
General Function
Structural constituent of cytoskeleton
Specific Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Gene Name
TUBB1
Uniprot ID
Q9H4B7
Uniprot Name
Tubulin beta-1 chain
Molecular Weight
50326.56 Da
References
  1. Gligorov J, Lotz JP: Preclinical pharmacology of the taxanes: implications of the differences. Oncologist. 2004;9 Suppl 2:3-8. [PubMed:15161985]
  2. Matesanz R, Barasoain I, Yang CG, Wang L, Li X, de Ines C, Coderch C, Gago F, Barbero JJ, Andreu JM, Fang WS, Diaz JF: Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel. Chem Biol. 2008 Jun;15(6):573-85. doi: 10.1016/j.chembiol.2008.05.008. [PubMed:18559268]
  3. Snyder JP, Nettles JH, Cornett B, Downing KH, Nogales E: The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5312-6. Epub 2001 Apr 17. [PubMed:11309480]
  4. Belani CP, Eckardt J: Development of docetaxel in advanced non-small-cell lung cancer. Lung Cancer. 2004 Dec;46 Suppl 2:S3-11. [PubMed:15698529]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Ubiquitin protein ligase binding
Specific Function
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appea...
Gene Name
BCL2
Uniprot ID
P10415
Uniprot Name
Apoptosis regulator Bcl-2
Molecular Weight
26265.66 Da
References
  1. Gligorov J, Lotz JP: Preclinical pharmacology of the taxanes: implications of the differences. Oncologist. 2004;9 Suppl 2:3-8. [PubMed:15161985]
  2. Marshall J, Chen H, Yang D, Figueira M, Bouker KB, Ling Y, Lippman M, Frankel SR, Hayes DF: A phase I trial of a Bcl-2 antisense (G3139) and weekly docetaxel in patients with advanced breast cancer and other solid tumors. Ann Oncol. 2004 Aug;15(8):1274-83. [PubMed:15277270]
  3. Inoue Y, Gika M, Abiko T, Oyama T, Saitoh Y, Yamazaki H, Nakamura M, Abe Y, Kawamura M, Kobayashi K: Bcl-2 overexpression enhances in vitro sensitivity against docetaxel in non-small cell lung cancer. Oncol Rep. 2005 Feb;13(2):259-64. [PubMed:15643508]
  4. Petrylak DP: Chemotherapy for androgen-independent prostate cancer. World J Urol. 2005 Feb;23(1):10-3. Epub 2005 Feb 1. [PubMed:15685445]
  5. Miyoshi Y, Uemura H, Kubota Y: [Treatment of androgen-independent hormone refractory prostate cancer using docetaxel]. Nihon Rinsho. 2005 Feb;63(2):298-302. [PubMed:15714982]
  6. Magi-Galluzzi C, Zhou M, Reuther AM, Dreicer R, Klein EA: Neoadjuvant docetaxel treatment for locally advanced prostate cancer: a clinicopathologic study. Cancer. 2007 Sep 15;110(6):1248-54. [PubMed:17674353]
Kind
Protein
Organism
Human
Pharmacological action
Yes
General Function
Structural molecule activity
Specific Function
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Gene Name
MAP2
Uniprot ID
P11137
Uniprot Name
Microtubule-associated protein 2
Molecular Weight
199524.51 Da
References
  1. McGrogan BT, Gilmartin B, Carney DN, McCann A: Taxanes, microtubules and chemoresistant breast cancer. Biochim Biophys Acta. 2008 Apr;1785(2):96-132. Epub 2007 Nov 12. [PubMed:18068131]
Kind
Protein
Organism
Human
Pharmacological action
Yes
General Function
Structural molecule activity
Specific Function
Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
Gene Name
MAP4
Uniprot ID
P27816
Uniprot Name
Microtubule-associated protein 4
Molecular Weight
121003.805 Da
References
  1. McGrogan BT, Gilmartin B, Carney DN, McCann A: Taxanes, microtubules and chemoresistant breast cancer. Biochim Biophys Acta. 2008 Apr;1785(2):96-132. Epub 2007 Nov 12. [PubMed:18068131]
Kind
Protein
Organism
Human
Pharmacological action
Yes
General Function
Structural constituent of cytoskeleton
Specific Function
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neu...
Gene Name
MAPT
Uniprot ID
P10636
Uniprot Name
Microtubule-associated protein tau
Molecular Weight
78927.025 Da
References
  1. McGrogan BT, Gilmartin B, Carney DN, McCann A: Taxanes, microtubules and chemoresistant breast cancer. Biochim Biophys Acta. 2008 Apr;1785(2):96-132. Epub 2007 Nov 12. [PubMed:18068131]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Binder
General Function
Zinc ion binding
Specific Function
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism an...
Gene Name
NR1I2
Uniprot ID
O75469
Uniprot Name
Nuclear receptor subfamily 1 group I member 2
Molecular Weight
49761.245 Da
References
  1. Ikezoe T, Hisatake Y, Takeuchi T, Ohtsuki Y, Yang Y, Said JW, Taguchi H, Koeffler HP: HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo. Cancer Res. 2004 Oct 15;64(20):7426-31. [PubMed:15492266]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Baumhakel M, Kasel D, Rao-Schymanski RA, Bocker R, Beckurts KT, Zaigler M, Barthold D, Fuhr U: Screening for inhibitory effects of antineoplastic agents on CYP3A4 in human liver microsomes. Int J Clin Pharmacol Ther. 2001 Dec;39(12):517-28. [PubMed:11770832]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
Inducer
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1B1
Uniprot ID
Q16678
Uniprot Name
Cytochrome P450 1B1
Molecular Weight
60845.33 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Wils P, Phung-Ba V, Warnery A, Lechardeur D, Raeissi S, Hidalgo IJ, Scherman D: Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers. Biochem Pharmacol. 1994 Oct 7;48(7):1528-30. [PubMed:7945455]
  2. Shirakawa K, Takara K, Tanigawara Y, Aoyama N, Kasuga M, Komada F, Sakaeda T, Okumura K: Interaction of docetaxel ("Taxotere") with human P-glycoprotein. Jpn J Cancer Res. 1999 Dec;90(12):1380-6. [PubMed:10665657]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Atpase activity, coupled to transmembrane movement of substances
Specific Function
ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.
Gene Name
ABCC10
Uniprot ID
Q5T3U5
Uniprot Name
Multidrug resistance-associated protein 7
Molecular Weight
161627.375 Da
References
  1. Hopper-Borge E, Xu X, Shen T, Shi Z, Chen ZS, Kruh GD: Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Cancer Res. 2009 Jan 1;69(1):178-84. doi: 10.1158/0008-5472.CAN-08-1420. [PubMed:19118001]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotre...
Gene Name
SLCO1B3
Uniprot ID
Q9NPD5
Uniprot Name
Solute carrier organic anion transporter family member 1B3
Molecular Weight
77402.175 Da
References
  1. Baker SD, Verweij J, Cusatis GA, van Schaik RH, Marsh S, Orwick SJ, Franke RM, Hu S, Schuetz EG, Lamba V, Messersmith WA, Wolff AC, Carducci MA, Sparreboom A: Pharmacogenetic pathway analysis of docetaxel elimination. Clin Pharmacol Ther. 2009 Feb;85(2):155-63. doi: 10.1038/clpt.2008.95. Epub 2008 May 28. [PubMed:18509327]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulf...
Gene Name
SLC22A7
Uniprot ID
Q9Y694
Uniprot Name
Solute carrier family 22 member 7
Molecular Weight
60025.025 Da
References
  1. Kobayashi Y, Ohshiro N, Sakai R, Ohbayashi M, Kohyama N, Yamamoto T: Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8. [PubMed:15901346]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Xenobiotic-transporting atpase activity
Specific Function
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both fro...
Gene Name
ABCG2
Uniprot ID
Q9UNQ0
Uniprot Name
ATP-binding cassette sub-family G member 2
Molecular Weight
72313.47 Da
References
  1. Fellner S, Bauer B, Miller DS, Schaffrik M, Fankhanel M, Spruss T, Bernhardt G, Graeff C, Farber L, Gschaidmeier H, Buschauer A, Fricker G: Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. J Clin Invest. 2002 Nov;110(9):1309-18. [PubMed:12417570]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Organic anion transmembrane transporter activity
Specific Function
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name
ABCC2
Uniprot ID
Q92887
Uniprot Name
Canalicular multispecific organic anion transporter 1
Molecular Weight
174205.64 Da
References
  1. Fellner S, Bauer B, Miller DS, Schaffrik M, Fankhanel M, Spruss T, Bernhardt G, Graeff C, Farber L, Gschaidmeier H, Buschauer A, Fricker G: Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. J Clin Invest. 2002 Nov;110(9):1309-18. [PubMed:12417570]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Transporter activity
Specific Function
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotre...
Gene Name
ABCC1
Uniprot ID
P33527
Uniprot Name
Multidrug resistance-associated protein 1
Molecular Weight
171589.5 Da
References
  1. Fellner S, Bauer B, Miller DS, Schaffrik M, Fankhanel M, Spruss T, Bernhardt G, Graeff C, Farber L, Gschaidmeier H, Buschauer A, Fricker G: Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. J Clin Invest. 2002 Nov;110(9):1309-18. [PubMed:12417570]

Drug created on June 13, 2005 07:24 / Updated on November 12, 2018 07:28