Acute Promyelocytic Leukemia (APL)

Also known as: Acute promyelocytic leukaemia / Acute promyelocytic leukemia / Leukemia, Promyelocytic, Acute / Acute promyelocytic leukemia with failed remission / M3 - Acute promyelocytic leukemia

DrugDrug NameDrug Description
DB00987CytarabineA pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia.
DB01033MercaptopurineAn antineoplastic agent used to treat acute lymphocytic leukemia.
DB00563MethotrexateAn antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis.
DB01204MitoxantroneA chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis.
DrugDrug NameTargetType
DB00987CytarabineDNA polymerase betatarget
DB00987CytarabineCytidine deaminaseenzyme
DB00987CytarabineSolute carrier family 22 member 4transporter
DB00987CytarabineMultidrug resistance-associated protein 7transporter
DB00987CytarabineEquilibrative nucleoside transporter 1transporter
DB00987CytarabineDNAtarget
DB00987CytarabineCytochrome P450 3A4enzyme
DB00987CytarabineDeoxycytidine kinaseenzyme
DB00987Cytarabine5'-nucleotidaseenzyme
DB00987CytarabineDeoxycytidylate deaminaseenzyme
DB01033MercaptopurineThiopurine S-methyltransferaseenzyme
DB01033MercaptopurineXanthine dehydrogenase/oxidaseenzyme
DB01033MercaptopurineHypoxanthine-guanine phosphoribosyltransferasetarget
DB01033MercaptopurineSolute carrier family 22 member 8transporter
DB01033MercaptopurineMultidrug resistance-associated protein 4transporter
DB01033MercaptopurineMultidrug resistance-associated protein 5transporter
DB01033MercaptopurineSodium/nucleoside cotransporter 2transporter
DB01033MercaptopurineSolute carrier family 28 member 3transporter
DB01033MercaptopurineEquilibrative nucleoside transporter 1transporter
DB01033MercaptopurineEquilibrative nucleoside transporter 2transporter
DB01033MercaptopurineAldehyde oxidaseenzyme
DB01033MercaptopurineAmidophosphoribosyltransferasetarget
DB01033MercaptopurineInosine-5'-monophosphate dehydrogenasetarget
DB00563MethotrexateDihydrofolate reductasetarget
DB00563MethotrexateAldehyde oxidaseenzyme
DB00563MethotrexateMethylenetetrahydrofolate reductaseenzyme
DB00563MethotrexateSerum albumincarrier
DB00563MethotrexateCanalicular multispecific organic anion transporter 2transporter
DB00563MethotrexateMultidrug resistance-associated protein 4transporter
DB00563MethotrexateMultidrug resistance-associated protein 1transporter
DB00563MethotrexateSolute carrier family 22 member 6transporter
DB00563MethotrexateMultidrug resistance-associated protein 7transporter
DB00563MethotrexateSolute carrier family 22 member 8transporter
DB00563MethotrexateCanalicular multispecific organic anion transporter 1transporter
DB00563MethotrexateP-glycoprotein 1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1A2transporter
DB00563MethotrexateMonocarboxylate transporter 1transporter
DB00563MethotrexateATP-binding cassette sub-family C member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B3transporter
DB00563MethotrexateSolute carrier family 22 member 11transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1C1transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 3A1transporter
DB00563MethotrexateATP-binding cassette sub-family G member 2transporter
DB00563MethotrexateSolute carrier family 22 member 7transporter
DB00563MethotrexateSolute carrier organic anion transporter family member 1B1transporter
DB00563Methotrexate6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00563MethotrexateProton-coupled folate transportertransporter
DB00563MethotrexateFolylpolyglutamate synthase, mitochondrialenzyme
DB00563MethotrexateGamma-glutamyl hydrolaseenzyme
DB00563MethotrexateDihydrofolate reductaseenzyme
DB00563MethotrexateThymidylate synthaseenzyme
DB00563MethotrexateBifunctional purine biosynthesis protein PURHenzyme
DB00563MethotrexateSolute carrier organic anion transporter family member 4C1transporter
DB00563MethotrexateFolate transporter 1transporter
DB00563MethotrexateFolate receptor alphatransporter
DB00563MethotrexateCytochrome P450 3A4enzyme
DB00563MethotrexateThymidylate synthasetarget
DB00563MethotrexateBifunctional purine biosynthesis protein PURHtarget
DB00563MethotrexateFolate receptor betatransporter
DB00563MethotrexateSolute carrier family 15 member 1transporter
DB00563MethotrexateProton-coupled amino acid transporter 1transporter
DB01204MitoxantroneDNA topoisomerase 2-alphatarget
DB01204MitoxantroneCytochrome P450 2E1enzyme
DB01204MitoxantroneP-glycoprotein 1transporter
DB01204MitoxantroneMultidrug resistance-associated protein 1transporter
DB01204MitoxantroneATP-binding cassette sub-family G member 2transporter
DB01204MitoxantroneDNAtarget
DB01204MitoxantroneCytochrome P450 1B1enzyme
DB01204MitoxantroneCytochrome P450 3A4enzyme
DrugDrug NamePhaseStatusCount
DB01169Arsenic trioxide1Terminated1
DB00631Clofarabine1Terminated1
DB00531Cyclophosphamide1Terminated1
DB00398Sorafenib1Completed1
DB04942Tamibarotene1Terminated1
DB11884Vadastuximab Talirine1Completed1
DB02546Vorinostat1Completed1
DB01169Arsenic trioxide2Active Not Recruiting1
DB01169Arsenic trioxide2Completed1
DB01169Arsenic trioxide2Recruiting1
DB01169Arsenic trioxide2Withdrawn1
DB11242Gelatin2Unknown Status1
DB00056Gemtuzumab ozogamicin2Completed1
DB05653IRX-51832Unknown Status1
DB05653IRX-51832Withdrawn1
DB01177Idarubicin2Completed1
DB04942Tamibarotene2Completed1
DB00755Tretinoin2Active Not Recruiting1
DB00755Tretinoin2Completed1
DB00755Tretinoin2Recruiting1
DB01169Arsenic trioxide2 / 3Unknown Status1
DB01169Arsenic trioxide3Active Not Recruiting1
DB01169Arsenic trioxide3Recruiting1
DB00987Cytarabine3Active Not Recruiting1
DB00987Cytarabine3Completed1
DB01005Hydroxyurea3Recruiting1
DB01177Idarubicin3Active Not Recruiting1
DB01033Mercaptopurine3Active Not Recruiting1
DB00563Methotrexate3Active Not Recruiting1
DB01204Mitoxantrone3Active Not Recruiting1
DB00755Tretinoin3Active Not Recruiting1
DB00755Tretinoin3Recruiting1
DB01169Arsenic trioxide4Active Not Recruiting1
DB01169Arsenic trioxide4Completed1
DB00987Cytarabine4Active Not Recruiting1
DB00987Cytarabine4Completed1
DB00987Cytarabine4Unknown Status1
DB00694Daunorubicin4Active Not Recruiting1
DB00694Daunorubicin4Unknown Status1
DB01177Idarubicin4Active Not Recruiting1
DB01177Idarubicin4Completed1
DB01177Idarubicin4Unknown Status1
DB01204Mitoxantrone4Completed1
DB01204Mitoxantrone4Unknown Status1
DB00755Tretinoin4Active Not Recruiting1
DB00755Tretinoin4Completed1
DB01169Arsenic trioxideNot AvailableNot Yet Recruiting1