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Identification
NameVitamin C
Accession NumberDB00126  (NUTR00001, APRD00084, EXPT00568, DB09541)
TypeSmall Molecule
GroupsApproved, Nutraceutical
DescriptionA six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. [PubChem]
Structure
Thumb
Synonyms
acide ascorbique
ácido ascórbico
acidum ascorbicum
acidum ascorbinicum
Ascorbate
Ascorbic Acid
Ascorbicap
Ascorbinsäure
L-(+)-ascorbic acid
L-Ascorbate
L-Ascorbic Acid
External Identifiers
  • E 300
  • E-300
  • E300
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ascor L 500Solution500 mgIntramuscular; Intravenous; SubcutaneousMcguff Pharmaceuticals Inc2014-09-11Not applicableCanada
Ascorbic Acid Inj 500mg/mlSolution500 mgIntramuscular; IntravenousKripps Pharmacy Ltd.1987-12-31Not applicableCanada
Ascorbic Acid Injection USP 500 mg/mlSolution500 mgIntramuscular; Intravenous; SubcutaneousAlveda Pharmaceuticals Inc2014-10-28Not applicableCanada
B.G. Plus FormulaTablet166.7 mgOralAbundance Marketing Ltd.Not applicableNot applicableCanada
Betac Ascorbic Acid Injection, USP 500mg/mlSolution500 mgIntramuscular; Intravenous; SubcutaneousBioniche Pharma (Canada) Ltd2002-10-312006-08-04Canada
Cataplex C Tab 5.7mgTablet5.7 mgOralStandard Process Inc.Not applicableNot applicableCanada
Chew C Berry Tablets - 125mgTablet125 mgOralMorter HealthsystemNot applicableNot applicableCanada
Chewable C Vitamin 300 Mg With AcerolaTablet300 mgOralLeiner Health Products Inc.Not applicableNot applicableCanada
Chewable Vitamin C 250 mgTablet250 mgOralLeiner Health Products Inc.Not applicableNot applicableCanada
Mega C Acid Inj 500mg/mlLiquid500 mgIntramuscular; Intravenous; SubcutaneousMerit Pharmaceuticals1984-12-312016-08-22Canada
Mega-C-sodium Inj 250mg/mlSolution250 mgIntravenousKripps Pharmacy Ltd.1981-12-31Not applicableCanada
Timed Release Vitamin C Tablet With BioflavanoidsTablet, extended release1000 mgOralChampion NutritionNot applicableNot applicableCanada
Vitamin CLiquid250 mgIntramuscular; IntravenousSandoz Canada Incorporated1989-12-31Not applicableCanada
Vitamin CSolution500 mgIntramuscular; Intravenous; SubcutaneousMylan Pharmaceuticals Ulc2002-05-29Not applicableCanada
Vitamin C 500mg TabletsTablet500 mgOralAshbury Research CorporationNot applicableNot applicableCanada
Vitamin C PowderPowder1250 mgOralSelf Health Resource CentreNot applicableNot applicableCanada
Vitamin C Tab USPTablet100 mgOralStandard Process Inc.Not applicableNot applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AcerotabTablet100 mgOralFrega Inc.1979-12-312008-02-13Canada
Acti-scorb 1000 Caplet 1000mgTablet1 gOralActi Form Ltd.1991-12-312005-03-21Canada
Acti-scorb 500 Caplet 500mgTablet500 mgOralActi Form Ltd.1991-12-312005-03-21Canada
All Natural Source Juicy Orange Vitamin CTablet500 mgOralWn Pharmaceuticals Ltd.1998-06-292009-09-28Canada
Ascorbate C-500Capsule500 mgOralSeroyal International Inc.1998-12-312001-08-09Canada
Ascorbic 500 Tab 500mgTablet500 mgOralPharmadex Laboratories Inc.1993-12-311999-08-28Canada
Ascorbic Acid 500mgTablet500 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Ascorbic Acid Cap 500mgCapsule500 mgOralThorne Research Canada Ltd.1984-12-312000-09-18Canada
Ascorbic Acid PowderPowder5 gOralAlbi Naturals1981-12-312008-07-17Canada
Ascorbic Acid Tab 1000mgTablet1 gOralBionatal Drug Co1977-12-311999-07-14Canada
Ascorbic Acid Tab 100mgTablet100 mgOralBionatal Drug Co1977-12-311999-07-14Canada
Ascorbic Acid Tab 250mgTablet250 mgOralBionatal Drug Co1977-12-311999-07-14Canada
Ascorbic Acid Tab 500mgTablet500 mgOralEverest Pharmaceuticals Ltd.1982-12-311999-07-14Canada
Ascorbic Acid Tab 500mgTablet500 mgOralBionatal Drug Co1977-12-311999-07-14Canada
Ascorbic Acid Tab 500mg USP W Non-med CherryTablet500 mgOralJamieson Laboratories Ltd1992-12-312002-06-25Canada
Babor Baborganic Biological Enzyme CleanserPowder.375 g/75gTopicalBabor Cosmetics America, Corp2008-11-01Not applicableUs
Bev C 1725 Tab 1000mgTablet1 gOralBeverly International Nutrition1986-12-311998-08-01Canada
Bio C 300 TabTablet300 mgOralLe Naturiste J.M.B. Inc.1980-12-312008-07-31Canada
Bio C 600 TabTablet600 mgOralHilcoa, Division Of Jeunique International1982-12-312006-12-11Canada
Bio Efferlife Vitamin C 1000mgTablet, effervescent1000 mgOralNaturale Science Inc.2003-06-212006-10-10Canada
Bio Flavono C Tab 100mgTablet100 mgOralLe Naturiste J.M.B. Inc.1980-12-312008-07-31Canada
Bio-cee Dietary SupplementTablet200 mgOralGarden State Nutritionals1998-08-312000-06-07Canada
Buffered Vitamin C 1000mgTablet1000 mgOralGeneral Nutrition Canada Inc.1997-11-262005-08-05Canada
Buffered Vitamin C Tab 500mgTablet500 mgOralSwiss Herbal Remedies Ltd.1981-12-312004-09-03Canada
C 1000Tablet1 gOralSeroyal International Inc.1988-12-312009-07-06Canada
C 3000Powder272 mgOralSeroyal International Inc.1980-12-312009-07-06Canada
C 350Tablet350 mgOralHilcoa, Division Of Jeunique International1973-12-311996-10-22Canada
C 500 Complete Tab 500mgTablet500 mgOralFlora Manufacturing And Distributing Ltd.1983-12-311999-10-18Canada
C 500mg Ascorbic AcidTablet500 mgOralWn Pharmaceuticals Ltd.1998-09-142003-08-01Canada
C ForteCapsule500 mgOralFrega Inc.1980-12-312008-02-13Canada
C Vite 100 Tab 100mgTablet100 mgOralPharmetics (2011) Inc1981-12-312000-08-21Canada
C Vite 150 Tab 150mgTablet150 mgOralPharmetics (2011) Inc1981-12-312006-07-27Canada
C Wafer 500 Chewable 500mgWafer500 mgOralNu Life Nutrition Ltd.1986-12-312000-05-23Canada
C-1000 Tab 1000mgTablet1 gOralSutra Health Systems Canada1986-12-311996-12-12Canada
C-1000 Tr Srt 1000mgTablet, extended release1 gOralNutri West Products Ltd.1988-12-312002-06-14Canada
C-500 CapletTablet500 mgOralHealth Wise Nutrition Inc.1994-12-312002-07-18Canada
C-500 Liq 50mg/mlLiquid50 mgOralBioforce Canada Inc.1994-12-311997-04-04Canada
C-curity-vitamin C CapCapsule375 mgOralEnrich International1994-12-312001-09-28Canada
C-rolla-250 Tab 250mg ChewableTablet250 mgOralNu Life Nutrition Ltd.1987-12-312000-05-23Canada
C1000 W Flavanoids TabTablet333 mgOralNutri Dyn Products Ltd.1976-12-311996-09-09Canada
C500 TabTablet500 mgOralNutri Dyn Products Ltd.1976-12-311996-09-09Canada
Calcium Ascorbate PwrPowder825 mgOralJamieson Laboratories Ltd1979-12-312000-09-08Canada
Ce Vi Sol DpsSolution / drops50 mgOralMead Johnson Nutritionals1977-12-311996-09-30Canada
Chewable Acerola C 500mgTablet500 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Chewable C Tab 100mgTablet100 mgOralGahler Enterprises Ltd.1988-12-312001-07-26Canada
Chewable Vitamin C 100mgTablet100 mgOralVitality Products Inc.1979-12-311999-04-23Canada
Chewable Vitamin C 250mg With Orange JuiceTablet250 mgOralVita Health Products Inc1997-09-082005-07-20Canada
Chewable Vitamin C Tab 250mgTablet250 mgOralSutra Health Systems Canada1986-12-311996-12-12Canada
Chewable Vitamin C Tab. 500 Mg Grape FlavourTablet500 mgOralVita Health Products Inc1995-12-312004-07-26Canada
Chewable Vitamin C Tablet 500mgTablet500 mgOralQuest Vitamins A Div Of Purity Life Health Products1989-12-312002-07-29Canada
Chewable Vitamin C Wafers 500mgWafer500 mgOralPharmavite Llc1987-12-312001-09-13Canada
Chewable Wafers Vitamin C 500 Mg - TabletTablet500 mgOralVita Health Products Inc1996-10-112002-07-31Canada
Comprime De Vitamine C 250mgTablet250 mgOralVitalab1990-12-312004-07-13Canada
Cran CCapsule100 mgOralHolista Health (Canada) Inc.1996-11-012006-08-02Canada
Daily Support CCapsule120 mgOralChanges International2000-10-012001-07-01Canada
Duo Cvp Cap 200mgCapsule200 mgOralAventis Pharma Inc1992-12-312002-07-29Canada
Effervescent Vit C 1000mgTablet, effervescent1 gOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1990-12-312000-07-27Canada
Ester - CTablet1000 mgOralNutraceutical Corporation2003-09-022007-08-02Canada
Ester CCapsule500 mgOralHolista Health (Canada) Inc.1996-11-132008-07-17Canada
Ester C 1000 mgTablet1000 mgOralHolista Health (Canada) Inc.2004-02-252007-08-03Canada
Ester C 1000mgTablet1000 mgOralWn Pharmaceuticals Ltd.2003-10-222008-07-17Canada
Ester-CTablet500 mgOralVita Health Products Inc1998-05-202004-07-26Canada
Ester-CTablet500 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1998-08-102002-07-31Canada
Ester-C (1000 Mg)Tablet1000 mgOralNatural Factors Nutritional Products Ltd.2002-04-242008-07-17Canada
Ester-C 500Tablet500 mgOralPharmetics (2011) Inc2002-09-302009-07-30Canada
Ester-C 500mgCapsule500 mgOralRegime Industries Ltd.2002-08-282008-07-10Canada
Ester-C With Non-medicinal Bioflavonoids, Quercetin, and Grape Seed ExtractTablet500 mgOralVita Health Products Inc2000-01-012004-07-26Canada
Exitox Tab 200mgTablet200 mgOralNutri Dyn Products Ltd.1982-12-311997-08-22Canada
Extra C 1000Tablet1000 mgOralLe Naturiste J.M.B. Inc.2001-02-022008-07-31Canada
Extra C 500Tablet500 mgOralLe Naturiste J.M.B. Inc.1999-07-072008-07-31Canada
Formula # 2 Pwr 15mg/gPowder15 mgOralGolden Pride/Rawleigh2001-06-212009-08-15Canada
Formula C-500 CapletTablet500 mgOralHealth Wise Nutrition Inc.1994-12-311998-08-25Canada
Formula Tc Vitamin C Tab 200mg USPTablet200 mgOralMetagenics, Inc.1997-01-272007-09-07Canada
Formula Vitamin C Tab 15mgTablet15 mgOralNature's Sunshine Products Of Canada Ltd.1995-12-311996-09-23Canada
Fruity Bita C Tablets 125mgTablet125 mgOralRoyal Bodycare Canada Inc.1992-12-312002-07-26Canada
Gnc Timed Release Vitamin C 1500mg TabletsTablet, extended release1.5 gOralGeneral Nutrition Canada Inc.2000-08-012005-08-05Canada
Gnc Timed Release Vitamin C Tablets 500mgTablet, extended release500 mgOralGeneral Nutrition Canada Inc.2000-08-012006-08-03Canada
Good Health FormulaCapsule250 mgOralPharmavite Llc1997-09-052000-08-24Canada
Hi-potent-C - CapCapsule500 mgOralHolista Health (Canada) Inc.1996-12-312001-08-01Canada
Hy C 3000 AnatabsTablet750 mgOralAnabolic Laboratories Inc.1970-12-311996-10-02Canada
Kamu Jay Liq 300mg/tspLiquid60 mgOralJamieson Laboratories Ltd1979-12-311997-08-13Canada
Kamu Jay Tab 150mgTablet150 mgOralJamieson Laboratories Ltd1977-12-312000-09-08Canada
Kanga CTablet, effervescent1000 mgOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-kid Vitamin CTablet, effervescent500 mgOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Life Vit C Timed Release Tab 1000mgTablet, extended release1 gOralShoppers Drug Mart Inc.1983-12-311997-08-15Canada
Life Vit C Timed Release Tab 500mgTablet, extended release500 mgOralShoppers Drug Mart Inc.1984-12-311997-08-15Canada
Liqud Vitamin CLiquid250 mgOralWn Pharmaceuticals Ltd.1999-11-122002-08-07Canada
Liquid Vitamin CLiquid250 mgOralNatural Factors Nutritional Products Ltd.1999-10-262007-08-07Canada
Liquid Vitamin C 500mgLiquid100 mgOralGeneral Nutrition Canada Inc.2003-09-202007-08-01Canada
Mega C 1000 Complex Tab 1000mgTablet1 gOralAlbi Naturals1988-12-312008-07-17Canada
Mega C 500 ComplexTablet500 mgOralAlbi Naturals1991-12-312009-07-15Canada
Mega C 500 Complex Tab 500mgTablet500 mgOralCountry Health Laboratories Ltd.1994-12-312001-07-27Canada
Mega C500 Complex Tab 500mgTablet500 mgOralCountry Health Laboratories Ltd.1994-12-312001-07-27Canada
Mr. Tumee WormsTablet, chewable30 mgOralVitamec Usa2003-04-152006-09-29Canada
Natural Fruit Chew C 250mg Tangy Orange FlavourTablet250 mgOralNatural Factors Nutritional Products Ltd.2001-01-012009-09-28Canada
Natural Source C 250 Tab 250mg ChewableTablet250 mgOralFlora Manufacturing And Distributing Ltd.1983-12-311997-09-24Canada
Neutral C With Echinacea & Lemon Bioflavonoids - CapCapsule660 mgOralNew Vision Nutritionals Company1998-06-072002-11-20Canada
NowCapsule25 mgOralChanges InternationalNot applicableNot applicableCanada
Now Ester-C 1000Tablet1000 mgOralNow Foods2005-04-212007-07-30Canada
Now Ester-C CapsCapsule500 mgOralNow Foods2005-04-212007-07-30Canada
Now Ester-C ComplexTablet500 mgOralNow Foods2005-04-212007-03-28Canada
Now Ester-C PowderPowder1000 mgOralNow Foods2005-05-162007-07-30Canada
Nutrol C Cap 150mgCapsule150 mgOralRolmex International Inc.1975-12-312008-07-09Canada
Nutrol C Tab 150mgTablet150 mgOralRolmex International Inc.1981-12-311997-08-08Canada
Orange C Tablets 150mgTablet150 mgOralGolden Neo Life Diamite International, Limited1993-12-311998-07-28Canada
Orange ChewableTablet500 mgOralDouglas Laboratories1995-12-312009-04-29Canada
Orti CCapsule500 mgOralSeroyal International Inc.1983-12-312009-07-06Canada
Phytomin C Tab 500mgTablet500 mgOralProduits Phyto Inc.1979-12-311996-09-17Canada
Phytomin-C 500 Tab 500mgTablet500 mgOralHorizon SantÉ International Inc.1979-12-312003-11-27Canada
Rocky Mountain Oj's Chewable Vitamin C TabTablet500 mgOralAlbi Naturals1992-12-312008-07-17Canada
Sago-C-500 Tab 500mgTablet500 mgOralNutri West Products Ltd.1993-12-312002-06-14Canada
ScorbatatePowder1 gOralSeroyal International Inc.1988-12-312009-07-06Canada
Sodium Ascor Crystal 888.8mg/gm USPPowder888.8 mgOralVita Health Products Inc1996-10-112002-07-31Canada
Softgel Vit.c 200mg From Ester-C Br.ca Asc.Capsule200 mgOralNatrol, Inc.1997-09-011999-08-10Canada
Super B.P. Vitamin CCapsule250 mgOralNutraceutical Corporation2003-09-022007-08-02Canada
Super C 1000mgTablet1000 mgOralWn Pharmaceuticals Ltd.1998-09-142008-07-17Canada
Super C With Non-medicinal Rosehips TabTablet500 mgOralJamieson Laboratories Ltd1994-12-312001-09-14Canada
Super Citro Cee Srt 500mgTablet, extended release500 mgOralAnabolic Laboratories Inc.1981-12-311996-10-02Canada
Supplement De Vitamine CKit30 mgOralYves Rocher Inc.1999-10-182000-10-02Canada
Sustained Release Vitamin C 500mgTablet, extended release500 mgOralDiet Center Worldwide Inc.1989-12-312008-07-22Canada
Sveets Orange BurstLozenge100 mgOralSensible Delights Specialty Foods1998-09-162000-09-19Canada
Swiss Camu C Tab 150mgTablet150 mgOralSwiss Herbal Remedies Ltd.1976-12-311998-07-15Canada
Synergisti-CCapsule650 mgOralThorne Research Inc.1997-09-092005-08-26Canada
Tgi Tab 50mgTablet50 mgOralSeroyal International Inc.1980-12-311996-09-10Canada
Tianshi Beneficial CapsulesCapsule8 mgOralTianjin Tianshi Group Co., Ltd.Not applicableNot applicableCanada
Time Rel Vit C Tab 1000mgTablet, extended release1 gOralLee Adams Laboratories1981-12-312009-12-02Canada
Time Release C 500mgTablet, extended release500 mgOralHealth Wise Nutrition Inc.1996-10-222002-07-18Canada
Timed C 1000 + Caplet 1000mgTablet1 gOralNu Life Nutrition Ltd.1997-08-152005-03-15Canada
Timed Release C 1000mg SrtTablet, extended release1 gOralJamieson Laboratories Ltd1994-12-312002-06-25Canada
Timed Release C 1000mg TabTablet, extended release1 gOralNutricorp International1993-12-312002-09-06Canada
Timed Release Vit. C-1000 CapletTablet, extended release1 gOralHealth Wise Nutrition Inc.1994-12-312002-07-18Canada
Timed Release Vitamin C 500 mgTablet, extended release500 mgOralAccurex Health Care Manufacturing Inc.1999-01-192009-07-31Canada
Timedose Vitamin C 1000mgTablet, extended release1 gOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1981-12-312004-07-26Canada
Timedose Vitamin C Tab 500mgTablet, extended release500 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1980-12-312004-07-26Canada
Tropicana Vitamin C SupplementSolution0.3 mgOralTropicana Canada2002-01-152007-06-21Canada
Vit C Chew Tab 300mgTablet300 mgOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Vit C Ctr 1000mgTablet, extended release1 gOralBioenergy Inc.1979-12-311998-06-03Canada
Vit C Ctr 500mgTablet, extended release500 mgOralBioenergy Inc.1979-12-311998-06-03Canada
Vit C Sustained Release Tab 1000mgTablet, extended release1 gOralPure Life International Prods Inc.1992-12-312000-07-27Canada
Vit C Tab 1000mgTablet1 gOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Vit C Tab 250mgTablet250 mgOralLaboratoire Lalco Inc.1976-12-311997-07-31Canada
Vit C Tab 250mgTablet250 mgOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Vit C Timed Release Tab 500mgTablet, extended release500 mgOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Vit.c With N-M.bioflav.rose Hips and RutinTablet500 mgOralVita Health Products Inc1996-10-112005-07-20Canada
Vita C 550 Ampoules Buvables 550mg/ampLiquid550 mgOralLe Naturiste J.M.B. Inc.1995-12-312002-06-19Canada
Vita C Tab 150mgTablet150 mgOralNutrimetics International (Canada) Inc.1985-12-311999-07-26Canada
Vita-worth Vitamin C Tablets 500mgTablet500 mgOralGeneral Nutrition Canada Inc.1997-11-272005-08-05Canada
Vitamin CCapsule500 mgOralNutraceutical CorporationNot applicableNot applicableCanada
Vitamin C 1000Tablet1 gOralOrganika Health Products Inc.1997-09-032004-06-28Canada
Vitamin C 1000Capsule1000 mgOralFlora Manufacturing And Distributing Ltd.2001-04-102009-08-05Canada
Vitamin C 1000 mgTablet1000 mgOralGfr Pharma Ltd.2002-10-202008-07-17Canada
Vitamin C 1000 Mg - TabletTablet1 gOralHealth Wise Nutrition Inc.1997-08-151998-08-25Canada
Vitamin C 1000 Mg Chewable - TabletTablet1 gOralPharmavite Llc1995-12-312000-08-24Canada
Vitamin C 1000 Mg Timed Release - TabletTablet, extended release1 gOralPharmavite Llc1995-09-012005-07-15Canada
Vitamin C 1000mgTablet1000 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Vitamin C 1000mg CapCapsule1 gOralThorne Research Canada Ltd.1997-04-182005-06-21Canada
Vitamin C 1000mg CapCapsule1 gOralFinlandia Consultants1990-12-311997-12-02Canada
Vitamin C 1000mg Dietary SupplementTablet1000 mgOralGarden State Nutritionals1998-09-222000-06-07Canada
Vitamin C 1000mg From Ester-C Brand Ca Asc.Tablet1 gOralNatrol, Inc.1997-09-012007-10-01Canada
Vitamin C 1000mg Time ReleaseTablet, extended release1000 mgOralWn Pharmaceuticals Ltd.1999-11-232009-09-28Canada
Vitamin C 1000mg Time Release FormTablet, extended release1 gOralVitality Products Inc.1979-12-311999-04-23Canada
Vitamin C 1000mg Timed Release TabletsTablet, extended release1 gOralWampole Brands, A Division Of Pangeo Pharma (Canada) Inc.1994-12-311997-08-11Canada
Vitamin C 1000mg W/ Non-medicinal EchinaceaTablet1 gOralJamieson Laboratories Ltd1993-12-311997-08-13Canada
Vitamin C 1000mg W/rose Hips Timed Release TabletTablet, extended release1000 mgOralPharmetics (2011) Inc1999-08-262009-07-30Canada
Vitamin C 100mg CapsulesCapsule100 mgOralHolista Health (Canada) Inc.1996-12-312002-08-06Canada
Vitamin C 1500mg - TabTablet1.5 gOralQuest Vitamins A Div Of Purity Life Health Products1996-11-211999-08-08Canada
Vitamin C 1500mg Time Released SrtTablet, extended release1.5 gOralNatural Factors Nutritional Products Ltd.1998-03-092002-08-02Canada
Vitamin C 1500mg Timed Release TabletTablet, extended release1.5 gOralAlive Vitamins1987-12-312002-07-12Canada
Vitamin C 250 mgTablet250 mgOralWn Pharmaceuticals Ltd.2002-03-132007-08-07Canada
Vitamin C 250 Mg Chewable - TabletTablet250 mgOralPharmavite Llc1995-12-312000-08-24Canada
Vitamin C 250mg With Non-medicinal Echinacea & Lemon BioflavonoidsCapsule250 mgOralGeneral Nutrition Canada Inc.1997-09-162005-08-05Canada
Vitamin C 250mg With Non-medicinal Rose HipsTablet250 mgOralVita Health Products Inc1995-12-312005-07-20Canada
Vitamin C 250mg With Non-medicinal Rose Hips Dietary SupplementTablet250 mgOralGarden State Nutritionals1998-08-312000-06-07Canada
Vitamin C 350 Tab 350mgTablet350 mgOralAvacare, Division Of Jeunique International Inc.1973-12-311997-11-10Canada
Vitamin C 400mg TabTablet400 mgOralSisu Inc.1990-12-311998-08-11Canada
Vitamin C 500 Mg TabTablet500 mgOralNature's Sunshine Products Of Canada Ltd.1995-12-311999-08-27Canada
Vitamin C 500 Mg (mixed Citrus Flavour)Tablet500 mgOralWn Pharmaceuticals Ltd.1999-04-302009-09-28Canada
Vitamin C 500 Mg Chewable - TabletTablet500 mgOralPharmavite Llc1995-12-312000-08-24Canada
Vitamin C 500 Mg With RosehipsTablet500 mgOralGfr Pharma Ltd.2002-10-102008-07-17Canada
Vitamin C 500mgTablet500 mgOralBioprint Laboratories Ltd2000-06-062002-08-01Canada
Vitamin C 500mgTablet500 mgOralWn Pharmaceuticals Ltd.1999-11-232009-09-28Canada
Vitamin C 500mgTablet500 mgOralWn Pharmaceuticals Ltd.1999-11-232008-07-17Canada
Vitamin C 500mg (chewable Orange)Tablet500 mgOralWn Pharmaceuticals Ltd.1999-04-302009-09-28Canada
Vitamin C 500mg Caps Time ReleaseCapsule, extended release500 mgOralLaboratoire Lalco Inc.1981-12-312007-08-16Canada
Vitamin C 500mg Src Time ReleaseCapsule, extended release500 mgOralSuperco Enr.1981-12-312008-11-19Canada
Vitamin C 500mg TabTablet500 mgOralNutricorp International1993-12-312009-08-05Canada
Vitamin C 500mg TabTablet500 mgOralJamieson Laboratories Ltd1994-12-312002-06-25Canada
Vitamin C 500mg TabletsTablet500 mgOralHolista Health (Canada) Inc.1997-07-022005-08-04Canada
Vitamin C 500mg Time ReleaseTablet, extended release500 mgOralWn Pharmaceuticals Ltd.1999-11-232005-08-15Canada
Vitamin C 500mg Timed ReleaseTablet, extended release500 mgOralPharmavite Llc1995-12-312005-07-15Canada
Vitamin C 500mg Timed Release Tab USPTablet, extended release500 mgOralJamieson Laboratories Ltd1980-12-312009-07-29Canada
Vitamin C 500mg Timed Release TabletsTablet, extended release500 mgOralWampole Brands1994-12-312004-06-29Canada
Vitamin C 500mg With Non-medicinal EchinaceaTablet500 mgOralHolista Health (Canada) Inc.1997-08-132002-08-06Canada
Vitamin C 500mg With Non-medicinal Rose HipsTablet500 mgOralGarden State Nutritionals1998-09-222000-06-07Canada
Vitamin C 600mgTablet600 mgOralGeneral Nutrition Canada Inc.2001-10-202005-08-05Canada
Vitamin C 60mgTablet60 mgOralWn Pharmaceuticals Ltd.1999-04-092008-07-17Canada
Vitamin C Ascorbic Acid Tab 1000mgTablet1 gOralShoppers Drug Mart Inc.1979-12-311999-08-11Canada
Vitamin C Cap 1000mgCapsule1 gOralRheingold Food International Ltd.1987-12-312007-07-26Canada
Vitamin C Chewable 250mgTablet250 mgOralGfr Pharma Ltd.2002-10-202004-06-15Canada
Vitamin C Chewable 500mgTablet500 mgOralGfr Pharma Ltd.2002-10-202004-06-11Canada
Vitamin C CrystalsPowder1200 mgOralWn Pharmaceuticals Ltd.2002-04-152006-08-08Canada
Vitamin C CrystalsPowder3 gOralAnabolic Laboratories Inc.1981-12-311996-10-02Canada
Vitamin C CrystalsPowder100 %OralVita Health Products Inc1982-12-312004-07-26Canada
Vitamin C CrystalsGranule1000 mgOralOrganika Health Products Inc.1997-05-102009-08-05Canada
Vitamin C CrystalsPowder2 gOralQuest Vitamins A Div Of Purity Life Health Products1979-12-311998-07-15Canada
Vitamin C CrystalsPowder1.3 gOralGahler Enterprises Ltd.1979-12-312007-08-07Canada
Vitamin C Crystals 5gm/5mlPowder5 gOralNutristar Health Products (1987) Inc.1983-12-311996-09-09Canada
Vitamin C Crystals Pwr 4000mg/tspPowder4 gOralNu Life Nutrition Ltd.1991-12-312005-03-15Canada
Vitamin C Extra Tab 500mgTablet500 mgOralGahler Enterprises Ltd.1979-12-311999-03-31Canada
Vitamin C Extra Time Released Tab 1800mgTablet, extended release1.8 gOralGahler Enterprises Ltd.1980-12-312000-08-01Canada
Vitamin C Orange Chewable Tab 500mg USPTablet500 mgOralVitalab1990-12-312005-07-12Canada
Vitamin C Src 500mg Timed ReleaseCapsule, extended release500 mgOralSwiss Herbal Remedies Ltd.1979-12-312003-09-10Canada
Vitamin C Srt 1.5gmTablet, extended release1.5 gOralAnabolic Laboratories Inc.1981-12-311996-10-02Canada
Vitamin C Srt 1000mgTablet, extended release1 gOralAnabolic Laboratories Inc.1981-12-311996-10-02Canada
Vitamin C Srt 1500mgTablet, extended release1.5 gOralJamieson Laboratories Ltd1978-12-312004-07-01Canada
Vitamin C Srt 500mgTablet, extended release500 mgOralBioforce Canada Inc.1985-12-311997-04-04Canada
Vitamin C Sustained Release Tabs 1000mgTablet, extended release1 gOralBioforce Canada Inc.1993-12-311997-07-22Canada
Vitamin C Tab 1000mgTablet1 gOralWeider Health Products1985-12-311999-09-09Canada
Vitamin C Tab 1000mgTablet1 gOralWampole Brands1973-12-312009-06-19Canada
Vitamin C Tab 1000mgTablet1 gOralVita Health Products Inc1979-12-312004-07-26Canada
Vitamin C Tab 1000mgTablet1 gOralCreative Nutrition Canada Corp.1984-12-312009-07-10Canada
Vitamin C Tab 1000mgTablet1 gOralIcn Canada Ltd.1976-12-312005-04-26Canada
Vitamin C Tab 1000mg Timed ReleaseTablet, extended release1 gOralVita Health Products Inc1996-10-112008-08-05Canada
Vitamin C Tab 1000mg USPTablet1 gOralPharmavite Llc1987-12-312006-07-05Canada
Vitamin C Tab 100mgTablet100 mgOralShoppers Drug Mart Inc.1977-12-311997-08-15Canada
Vitamin C Tab 100mgTablet100 mgOralPharmetics (2011) Inc1973-12-311998-09-15Canada
Vitamin C Tab 100mgTablet100 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1972-12-312002-07-31Canada
Vitamin C Tab 100mgTablet100 mgOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Vitamin C Tab 100mgTablet100 mgOralLes Produits Gerbex Inc.1970-12-311997-08-11Canada
Vitamin C Tab 100mgTablet100 mgOralWampole Brands, A Division Of Pangeo Pharma (Canada) Inc.1973-12-311996-09-09Canada
Vitamin C Tab 100mgTablet100 mgOralVita Health Products Inc1985-12-312002-07-31Canada
Vitamin C Tab 1500mg Timed ReleaseTablet, extended release1.5 gOralSwiss Herbal Remedies Ltd.1979-12-312007-07-31Canada
Vitamin C Tab 250mgTablet250 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1972-12-312002-07-31Canada
Vitamin C Tab 250mgTablet250 mgOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Vitamin C Tab 250mgTablet250 mgOralRandle Labs Inc.1987-12-311997-05-30Canada
Vitamin C Tab 250mgTablet250 mgOralShoppers Drug Mart Inc.1977-12-311998-08-14Canada
Vitamin C Tab 250mgTablet250 mgOralAlbi Imports Ltd.1980-12-311996-09-09Canada
Vitamin C Tab 250mgTablet250 mgOralWampole Brands1973-12-312004-06-29Canada
Vitamin C Tab 250mg USPTablet250 mgOralPharmavite Llc1987-12-312000-08-24Canada
Vitamin C Tab 250mg WatkinsTablet250 mgOralWatkins Incorporated1975-12-312000-01-15Canada
Vitamin C Tab 500 mgTablet500 mgOralPurity Life Health Products A Division Of Sunopta Inc.2002-06-012007-07-26Canada
Vitamin C Tab 500mgTablet500 mgOralJamieson Laboratories Ltd1979-12-312009-07-29Canada
Vitamin C Tab 500mgTablet500 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1972-12-312002-07-31Canada
Vitamin C Tab 500mgTablet500 mgOralVitality Products Inc.1979-12-311999-04-23Canada
Vitamin C Tab 500mgTablet500 mgOralRheingold Food International Ltd.1985-12-311996-09-16Canada
Vitamin C Tab 500mgTablet500 mgOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Vitamin C Tab 500mgTablet500 mgOralAlbi Imports Ltd.1979-12-311996-09-09Canada
Vitamin C Tab 500mgTablet500 mgOralRandle Labs Inc.1987-12-311997-05-30Canada
Vitamin C Tab 500mgTablet500 mgOralNutristar Health Products (1987) Inc.1979-12-311996-09-09Canada
Vitamin C Tab 500mgTablet500 mgOralLaboratoire Lalco Inc.1974-12-312008-07-29Canada
Vitamin C Tab 500mgTablet500 mgOralAlive Vitamins1984-12-312004-07-08Canada
Vitamin C Tab 500mgTablet500 mgOralNutristar Health Products (1987) Inc.1979-12-311996-09-09Canada
Vitamin C Tab 500mgTablet500 mgOralShoppers Drug Mart Inc.1977-12-311997-08-15Canada
Vitamin C Tab 500mgTablet500 mgOralLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.1973-12-311999-01-22Canada
Vitamin C Tab 500mg ChewableTablet500 mgOralSwiss Herbal Remedies Ltd.1987-12-311998-07-15Canada
Vitamin C Tab 500mg USPTablet500 mgOralPharmavite Llc1987-12-312006-07-05Canada
Vitamin C Tab 500mg USPTablet500 mgOralPharmavite Llc1995-12-312002-07-25Canada
Vitamin C Tablets 1000mgTablet1000 mgOralD.C. Labs Limited1982-12-312005-07-19Canada
Vitamin C Tablets 1500mg Timed ReleaseTablet, extended release1.5 gOralVita Health Products Inc1995-12-312004-07-26Canada
Vitamin C Tablets 250mgTablet250 mgOralD.C. Labs Limited1973-12-312003-07-11Canada
Vitamin C Tablets 500mgTablet500 mgOralInternational Nutrition Ltd.1996-07-262001-08-17Canada
Vitamin C Tablets 500mgTablet500 mgOralD.C. Labs Limited1973-12-312005-07-19Canada
Vitamin C Tablets 500mgTablet500 mgOralTechnilab Pharma Inc.1997-08-192005-08-05Canada
Vitamin C Tablets Sustained Release 500mgTablet, extended release500 mgOralD.C. Labs Limited1987-12-312003-07-11Canada
Vitamin C Tablets Time Release 1000mgTablet, extended release1 gOralInternational Nutrition Ltd.1996-07-262001-08-17Canada
Vitamin C Tablets Time Release 500mgTablet, extended release500 mgOralInternational Nutrition Ltd.1996-07-262001-08-17Canada
Vitamin C Tablets USP 500mgTablet500 mgOralNpr Laboratories Inc.Not applicableNot applicableCanada
Vitamin C Timed Release Tab 1000mgTablet, extended release1 gOralLaboratoire Lalco Inc.1989-12-312007-08-16Canada
Vitamin C Timed Release Tab 1000mgTablet, extended release1 gOralNobel Pharm Enr.1995-12-312001-10-15Canada
Vitamin C Timed Release Tab 1500mgTablet, extended release1.5 gOralVita Health Products Inc1986-12-312005-07-20Canada
Vitamin C Timed Release Tab 1500mgTablet, extended release1.5 gOralAlbi Naturals1985-12-312008-07-17Canada
Vitamin C Timed Release Tab 500mgTablet, extended release500 mgOralAlbi Imports Ltd.1985-12-312006-08-04Canada
Vitamin C Ultra Fine Pwr 1000mg/tspPowder1 gOralKlaire Labs Inc.1983-12-311999-01-18Canada
Vitamin C-force 1000mg TabletsTablet1000 mgOralPrairie Naturals2001-12-292005-09-25Canada
Vitamin C-force 500mg TabletsTablet500 mgOralPrairie Naturals2001-12-292005-09-25Canada
Vitamine C 250 Mg Masticable - TabletTablet250 mgOralNobel Pharm Enr.1995-12-312001-10-15Canada
Vitamine C 250 Mg USP - TabletTablet250 mgOralNobel Pharm Enr.1995-12-312000-08-01Canada
Vitamine C 500 Mg Raisin - TabletTablet500 mgOralNobel Pharm Enr.1995-12-312001-10-15Canada
Vitamine C 500 Mg USP - TabletTablet500 mgOralNobel Pharm Enr.1995-12-312001-10-15Canada
Vitamine C - Liq Orl 50mg/mlLiquid50 mgOralLand Art Inc.1996-10-292008-06-26Canada
Vitamine C 1000 Action ProlongeeTablet, extended release1000 mgOralGamme Nature1989-12-312008-07-31Canada
Vitamine C 1000 Tab 1000mgTablet1 gOralLe Naturiste J.M.B. Inc.1990-12-312001-08-01Canada
Vitamine C 1000mg-liqLiquid1 gOralLe Naturiste J.M.B. Inc.1995-12-312008-07-31Canada
Vitamine C 150 mgCapsule150 mgOralLes Produits Gerbex Inc.1971-12-312008-08-14Canada
Vitamine C 500Tablet500 mgOralLaboratoire Lalco Inc.1998-06-052008-07-29Canada
Vitamine C 500 Action ProlongeeTablet, extended release500 mgOralGamme Nature1990-12-312004-07-26Canada
Vitamine C Cap 500mgCapsule500 mgOralPharmalab Inc.1995-12-311997-08-08Canada
Vitamine C Cap 500mgCapsule500 mgOralAlsi Cie Ltee1988-12-312003-05-21Canada
Vitamine C Liq 500mg/10mlLiquid500 mgOralSantÉ Naturelle (Ag) LtÉe1993-12-312007-08-03Canada
Vitamine C Tab 100mgTablet100 mgOralCarmaran LtÉe1979-12-311996-09-09Canada
Vitamine C Tab 100mg MasticablesTablet100 mgOralLaboratoire Lalco Inc.1980-12-311997-07-31Canada
Vitamine C Tab 100mg USPTablet100 mgOralNobel Pharm Enr.1988-12-311997-07-31Canada
Vitamine C Timed Release Tab 500mgTablet, extended release500 mgOralNobel Pharm Enr.1989-12-311998-08-14Canada
Vitamine C Timed Release Tab 500mgTablet, extended release500 mgOralLaboratoire Lalco Inc.1989-12-312007-08-16Canada
Vitarich CTablet500 mgOralWn Pharmaceuticals Ltd.2000-07-072002-08-02Canada
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ascorbic AcidInjection, solution500 mg/mLIntramuscular; Intravenous; SubcutaneousThe Torrance Company1999-06-01Not applicableUs
Ascorbic AcidInjection, solution500 mg/mLIntramuscular; Intravenous; SubcutaneousAmerican Regent, Inc.1989-12-15Not applicableUs
Ascorbic AcidInjection, solution500 mg/mLIntramuscular; Intravenous; SubcutaneousMylan Institutional LLC1999-06-01Not applicableUs
Ascorbic AcidInjection, solution500 mg/mLIntravenousREMEDYREPACK INC.2015-10-092016-03-29Us
Ascorbic AcidInjection, solution500 mg/mLIntramuscular; Intravenous; SubcutaneousRaw Materials International Overseas Llc2015-07-02Not applicableUs
Ascorbic AcidInjection, solution500 mg/mLIntramuscular; Intravenous; SubcutaneousMylan Institutional LLC1999-06-01Not applicableUs
Dr Cellapy SR PremiumKitGm Holdings Co., Ltd2014-10-10Not applicableUs
Mega-C-acid PlusInjection, solution500 mg/mLIntramuscular; Intravenous; SubcutaneousMerit Pharmaceutical2010-01-01Not applicableUs
International Brands
NameCompany
AscoltinNot Available
AscorbicapNot Available
Brand mixtures
NameLabellerIngredients
A & C PowderStandard Process Inc.
Acetabolan III Vitamin and Mineral SupplementIovate Health Sciences International Inc.
Acetabolan-II Vitamin and Mineral SupplementIovate Health Sciences International Inc.
Acti-megascorb Crystals PwrActi Form Ltd.
Acti-MN + B1 + C CapletActi Form Ltd.
Active FeGm Pharmaceuticals, Inc.
Adc ComprimesBio Vita
Adrenergy TabletsMorter Healthsystem
Allbee With C 550 CapWhitehall Robins Inc.
Allbee With Vitamin C CapWhitehall Robins Inc.
Am CapsNew Vision Nutritionals Company
AmdSeroyal International Inc.
Animal Shaped Chew Vit C Tab 250mgHall Laboratories, Ltd.
AntlervironClassical Remedia Ltd
AppedrineChattem Canada
ArmaxEnzymatic Therapy (Canada) Inc.
Ascorbex 500 TabSantÉ Naturelle (Ag) LtÉe
Ascorbic Acid Tab 500mg Orange FlavouredStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Astral C TabAlbi Naturals
B & J Formula Dietary SupplementGarden State Nutritionals
B C Antistress CapLes Laboratoires Bio SantÉ Inc.
B Complex 500 TabNobel Pharm Enr.
B Complex Plus C 300mg TabNutricorp International
B Complex W C and B12 InjE L Stickley And Co Ltd.
B Complex W C Forte CapEverest Pharmaceuticals Ltd.
B Complex W Vit C W Non-med Yeast&liver TabPharmavite Llc
B Complex W Vitamin C Fortis CapShoppers Drug Mart Inc.
B Complex With C 300mgVita Health Products Inc
B Complex With C 300mg TabPharmavite Llc
B Complex With C 550mgVita Health Products Inc
B Plus C 300 mgVita Health Products Inc
B Plus C 300mg Timed ReleaseVita Health Products Inc
B Stress C + Iron & ViteStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
B Totum 500Desbergers LtÉe, Division Of Technilab Inc.
B VirolRolmex International Inc.
B With C 500 CapPharmetics (2011) Inc
B-2 100mg With C 20mgGahler Enterprises Ltd.
B-complex With Vitamin C, Biotin, Folic AcidWn Pharmaceuticals Ltd.
B-plexWn Pharmaceuticals Ltd.
B-plus - TabChampion's Choice Advanced Nutrition Inc.
BacminMarnel Pharmaceuticals, Inc.
Balanced B-complex Vit + Vit C&e TabPharmavite Llc
Beautel Supplement De Vitamines Et MineralNobel Pharm Enr.
Beminal W C Fortis InjAyerst Laboratories
Beminal With C Fortis CapWyeth Ayerst Canada Inc.
Beminal With C Fortis PwsWyeth Ayerst Canada Inc.
Beta-carotene 10,000 Iu With Vitamins C & EJamieson Laboratories Ltd
Betafant TabLes Laboratoires Vachon Inc.
Bioferr 90Biocomp Pharma, Inc.
Biovim TabLe Naturiste J.M.B. Inc.
BiovitaIldong Pharmaceutical Co., Ltd.
Bodysmarts With Vitamins A, C and ECadbury Adams Canada Inc.
BseltzerAbundance Marketing Ltd.
Buffered Vitamin C Plus MagnesiumTwin Laboratories Inc.
Buffered Vitamin C Powder With Ca Mg and KThorne Research Canada Ltd.
Buffered Vitamin C Pwr W Cal-mag-potassiumSisu Inc.
Bugs Bunny and Friends Multiple VitaminsBayer Inc Consumer Care
Bugs Bunny Chew Multi Vit Plus IronMiles Canada Inc. Consumer Health Care Division
C 106 TabNf Formulas Inc.
C-apnto-B6 Vitamins W Magnesium TabMetagenics, Inc.
C-B ComplexAvacare, Division Of Jeunique International Inc.
C-crystals With CalciumAlive Vitamins
C-forcePrairie Naturals
C-nate DHACenturion Labs, Llc
C-plus - TabChampion's Choice Advanced Nutrition Inc.
C.A.G. TabNutrition For Life International
C.H.V. FormulaNihon Kenko Zoushin Kenkyukai Canada Inc., Subsidery Of Nikken Usa Inc.
Cal & Mag Hvp Chel Plus C Potass & Zinc TabGahler Enterprises Ltd.
Cal Mag Drink With Vitamin CWampole Brands
Cal-mag Complete With Zinc, C and DQuest Vitamins A Div Of Purity Life Health Products
Cal-mag Vitamin C and Zinc TabSwiss Herbal Remedies Ltd.
Calcium Ascorbate 1000 Mg - TabletHealth Wise Nutrition Inc.
Calcium Ascorbate Cap 850mgQuest Vitamins A Div Of Purity Life Health Products
Calcium Ascorbate Ctr Srt 450mgBioenergy Inc.
Calcium Ascorbate Tab 550mgEster C Health Co, Division Of Inter Cal Corp
Calcium Complex High GradeNew Spirit Naturals, Inc.
Calcium Magnesium Avec Vitamine CLes Aliments Nutri Source Inc.
Calcium With Mg Zn Mn Cu CR Si and Vit. C & DJamieson Laboratories Ltd
Calcium With Vitamins C and D TabPure Life International Prods Inc.
CalmaxMedia Power, Inc.
CalplusLifestyles Canada Corporation
Carbassist TabletsWyeth Consumer Healthcare Inc.
CarbawayAbundance Marketing Ltd.
Carti-aide TabAvant Garde, Les SupplÉments
Cataplex A-C TabStandard Process Inc.
Cda-21 Vitamins With Non-medicinal Probiotic ComplexRx Vitamins Inc.
Cedevita Plus Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Cedevita Sugar-free Vitamin SupplementPliva, Pharmaceutical, Chemical, Food And Cosmetic Industry, Inc.
Cell-wiseMelaleuca Of Canada Inc.
Cell-wise Natural SourceMelaleuca Of Canada Inc.
Chela-manganese 50 PlusNu Life Nutrition Ltd.
Chelated Cal-mag(2:1)with Zn Vit.c and DHealth Wise Nutrition Inc.
Chelated Cal/mag/zn With VitaminsHealth Wise Nutrition Inc.
Chew.multiple Vits.with Extra C for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vit Plus Iron for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vitamins for ChildrenRandle Pharmaceutical Inc.
Chewable Multiple Vitamins Plus Extra CRandle Pharmaceutical Inc.
Chewable Multiple Vitamins Plus Iron TabRandle Pharmaceutical Inc.
Chewable Multiple Vitamins TabRandle Pharmaceutical Inc.
Chewable MultivitaminsWn Pharmaceuticals Ltd.
Chewable Multivitamins Plus IronWn Pharmaceuticals Ltd.
Chewable Vit C 100mgBioforce Canada Inc.
Chewable Vitamin C 100mg - TabVita Health Products Inc
Chewable Vitamin C 250mgVita Health Products Inc
Chewable Vitamin C 500mgRandle Labs Inc.
Chewable Vitamin C 500mg TabHall Laboratories, Ltd.
Chewable Vitamin C Tab 1000mgWampole Brands
Children Choice Multivit Chewable TabSwiss Herbal Remedies Ltd.
Children Choice Multivitamin W Iron Chew TabSwiss Herbal Remedies Ltd.
Children Pediatric Vitamins DropsStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children Vitamin DropsWampole Brands, A Division Of Pangeo Pharma (Canada) Inc.
Children's Chewable Multi Vit W IronShoppers Drug Mart Inc.
Children's Chewable Multi VitaminsShoppers Drug Mart Inc.
Children's Chewable Multi Vitamins With Iron TabletsVita Health Products Inc
Children's Chewable Multi-vitaminWn Pharmaceuticals Ltd.
Children's Chewable Multi-vitamin Complete With MineralsWn Pharmaceuticals Ltd.
Children's Chewable Multiple Vit.plus IronStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children's Chewable Multiple Vitamins - TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Children's Chewable Multiple Vitamins (chewable Tablets)Pharmetics (2011) Inc
Children's Chewable Multiple Vitamins With Extra Vitamin C (chewable Tablets)Pharmetics (2011) Inc
Children's Chewable Multiple Vitamins With Iron Tablets (chewable Tablets)Pharmetics (2011) Inc
Children's Vitamins ChewableVita Health Products Inc
Children's Vitamins W Iron ChewableVita Health Products Inc
Childrens Chew Multi Vitamin TabNutristar Health Products (1987) Inc.
Childrens Chewable Multiple VitaminsKsl Pharmaceuticals
Childrens Chewable Multiple Vitamins Plus FeKsl Pharmaceuticals
Childrens Chewable Multiple Vitamins TabPharmavite Llc
Childrens Chewable MultivitaminsRandle Labs Inc.
Childrens Chewable Multivitamins W IronRandle Labs Inc.
Childrens Chewable Vitamin TabPharmetics (2011) Inc
Childrens Chewable VitaminsD.C. Labs Limited
Childrens Multiple Vit and Min Chew TabCountry Health Laboratories Ltd.
Citranatal B-calmMission Pharmacal Company
Citranatal DHAMission Pharmacal Company
Citranatal RxMission Pharmacal Company
Citron Chaud Cumberland PwsProdemdis Enr.
Citron Chaud DM Cumberland PwsProdemdis Enr.
Citron Chaud DM Option + PwsProdemdis Enr.
Citron Chaud Extra FortPharmalab Inc.
Cmp PlexNutraceutical Corporation
Cold & FluPharmascience Inc
Cold and SinusPharmetics (2011) Inc
Complete Multivitamins and Minerals Tablets Timed ReleasePharmetics (2011) Inc
Concept DHAUs Pharmaceutical Corporation
Concept ObUs Pharmaceutical Corporation
Contac Extend-C Sustained Release CapsulesGlaxosmithkline Consumer Healthcare Inc.
Croq-vit Pour EnfantsNutrivac Ltee
CyroplexTherapeutic Foods Co.
Cyruta TabTherapeutic Foods Co.
D Pantothenic 500mg With 100mg CGahler Enterprises Ltd.
Derma-forcePrairie Naturals
Dexatrim TabletsChattem Canada
Dia-viteR & D Laboratories Inc.
DiaplexNephro Tech, Inc.
Dinosaurs Im-rapNutraceutical Corporation
Dual MixOmnilife Manufactura, S.A. De C.V.
Dynam Ampoule Et TabletCardinaux Enrg Les Produits Naturels
E.V.C. Vitamins TabSisu Inc.
EC + ComplexSeroyal International Inc.
Efferlife Calcium 500mg + Vitamin D3 440 Iu + Vitamin C 125mgNaturale Science Inc.
Efferlife Multivitamins and MineralsNaturale Science Inc.
Effervescent Vitamin C Powder With Ca and mgThorne Research Canada Ltd.
Eky Efferlife Vitamin C 1000mg With ZincNaturale Science Inc.
Enviroflex - TabEnviro Tech International Canada
EnviveSisu Inc.
EnzogenolSisu Inc.
EscaviteGm Pharmaceuticals, Inc.
Ester C 500 TabNu Life Nutrition Ltd.
Ester C Calcium Ascorbate CapNatrol, Inc.
Ester C CapsuleNatural Factors Nutritional Products Ltd.
Ester C PowderNatural Factors Nutritional Products Ltd.
Ester C Tab ChewableNatrol, Inc.
Ester C Vitamin C and Calcium PwsNatrol, Inc.
Ester-CNatural Factors Nutritional Products Ltd.
Ester-C 500 mgWn Pharmaceuticals Ltd.
Ester-C 600 mgWn Pharmaceuticals Ltd.
Ester-C 787mgNatural Factors Nutritional Products Ltd.
Ester-C Calcium Ascor TabNatrol, Inc.
Ester-C Calcium Ascorbate CapsulesSwiss Herbal Remedies Ltd.
Ester-C Calcium Ascorbate TabNatrol, Inc.
Ester-C Calcium Ascorbate TabletsSwiss Herbal Remedies Ltd.
Ester-C PowderNatural Factors Nutritional Products Ltd.
Ester-C TabletNatural Factors Nutritional Products Ltd.
Ester-C Vitamin C With CalciumDarwen Holdings Ltd.
Evc - LiqSisu Inc.
Evc Liquid Vitamins A,c,b6 With Beta Caro&znNf Formulas Inc.
Everyday Multiple VitaminsD.C. Labs Limited
Everyday Multiple Vitamins With IronD.C. Labs Limited
Extra P.N. Vitamin-mineral Drink MixChanges International
Extra Strength PharmacitronPharmascience Inc
Extra-virt Plus DHAVirtus Pharmaceuticals LLC
Fe C TabBoca Pharmacal, LLC
Fe C Tab PlusBoca Pharmacal, LLC
Fem - ControlMetagenics, Inc.
Fem - PmtMetagenics, Inc.
Feminex 300 TabSantÉ Naturelle (Ag) LtÉe
Feminique W Iron and Calcium TabStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Femitab TabLe Groupe Prodeal Ltee
FerivaAvion Pharmaceuticals, Llc
Feriva FaAvion Pharmaceuticals, Llc
FerivafaAvion Pharmaceuticals, Llc
Fero Grad 500Abbott Laboratories, Limited
Ferra Naka Plus VitaminsNaka Sales Ltd.
Ferralet 90Mission Pharmacal Company
Fib-C MeltsApm Products Pty Ltd.
Flinstones Multiple Plus IronMiles Canada Inc. Consumer Health Care Division
Flintstones Multiple VitaminsBayer Inc Consumer Care
Flintstones Multiple Vitamins Plus IronBayer Inc Consumer Care
Flintstones Multiple Vitamins TabMiles Canada Inc. Consumer Health Care Division
Flintstones W Extra C TabMiles Canada Inc. Consumer Health Care Division
Floravit - SyrFlora Manufacturing And Distributing Ltd.
FlorivaBon Geo Pharmaceuticals, Inc.
Floriva PlusBon Geo Pharmaceuticals, Inc.
Folet OnePronova Corporation
Folic Acid & Vitamin CHolista Health (Canada) Inc.
Folic Acid 1mg With C 20mgGahler Enterprises Ltd.
Folic Acid 1mg With Vitamin CWn Pharmaceuticals Ltd.
Folic Acid With Vitamin B12 and Vitamin CFlora Manufacturing And Distributing Ltd.
Foltabs PrenatalMidlothian Laboratories
For Kids Only Chewable Multivit. Plus IronKsl Pharmaceuticals
For Kids Only Chewable Multivitamins - TabKsl Pharmaceuticals
Formula 14 Dietary SupplementRx Vitamins Inc.
Formula A.R.-th Dietary SupplementRx Vitamins Inc.
Formula CFKroeger Herb Products
Formula CnBalance Plus, Inc.
Formula Csp With Vitamins A C and Zinc LozQuantum Inc.
Formula CwBody Wise International Llc
Formula Cw-capletBody Wise International Llc
Formula Fm Vitamins & Minerals TabMetagenics, Inc.
Formula Im-vitamins and Minerals TabMetagenics, Inc.
Formula Imgrd - TabHealth Wise Nutrition Inc.
Formula InfBalance Plus, Inc.
Formula LfNumark Laboratories, Inc.
Formula No. 2 Plus K LiqGolden Pride/Rawleigh
Formula OGeneral Nutrition Canada Inc.
Formula R TabMetagenics, Inc.
Formule 7561 CapsTherapeutic Foods Co.
Formule No 204 Profil TabPharmalab Inc.
Fortamines 10 CapsulesRougier Pharma Division Of Ratiopharm Inc
Fortamines-10 ComprimesRougier Pharma Division Of Ratiopharm Inc
Fortifi-plusClinique Lafontaine Inc, Division Les Importations Ortho
Fortistress TabSantÉ Naturelle (Ag) LtÉe
Forty Plus Vitamin SupplementGarden State Nutritionals
Fusion Activator Formula TabL & S Research Corporation
Garfield Chewable Multivits Plus Iron TabWhitehall Robins Inc.
Gemvites Jr Tab ChewablePharmavite Laboratories (1987) Inc.
Gestamine ComprimesLab Nadeau LtÉe, Division Of Technilab Inc.
Gesticare DHAJazz Pharmaceuticals Commercial Corp.
Glyco-aide TabAvant Garde, Les SupplÉments
Golf Vitamin and Mineral SupplementMuscle Marketing Usa Inc.
Good Night/pm Formula TabNikken Usa, Incorporated
Grippalin & C TabDistributions Multi Pro Inc.
Guardyn TabNutri Dyn Products Ltd.
Healthy Mamabe Well Rounded Be Well RoundedMATERNAL SCIENCE, LLC
Hemarexin TabLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.
HematogenNnodum Pharmaceuticals
Hematogen FaNnodum Pharmaceuticals
Hematogen ForteNnodum Pharmaceuticals
Hi Potency B52 B Complex TabCountry Health Laboratories Ltd.
Hi Potency Stress B Tension With CLee Adams Laboratories
High Potency Vitamin B Complex + C TabVita Health Products Inc
Hill.viteHillestad Pharmaceuticals Usa
Homosistrol CapsulesMacromed Pharmicia Inc.
Hot Lemon Cold and Flu Relief Extra StrengthPharmanutrients Botanical Corporation
Hot Lemon Cold and Flu Relief Regular StrengthPharmanutrients Botanical Corporation
Hot Lemon Extra StrengthProdemdis Enr.
Hot Lemon for Colds PowderRandle Labs Inc.
Hot Lemon Regular - PwrProdemdis Enr.
Hot Lemon Relief Pck-pwsApotex Inc
Hot Lemon Relief - Extra StrengthJamp Pharma Corporation
Hot Lemon Relief for Cold Symptoms Ext StrPatheon Laboratories
Hot Lemon Relief for Cold Symptoms PwsPatheon Laboratories
Hot Lemon Relief for Symptoms Of Cold and Flu Extra StrengthPharmetics (2011) Inc
Hot Lemon Relief for Symptoms Of Cold and Flu FortePharmetics (2011) Inc
Hot Lemon Relief for Symptoms Of Cold and Flu Regular StrengthPharmetics (2011) Inc
Hot Lemon Relief for Symptoms Of Cough and ColdPharmetics (2011) Inc
Hot Lemon Relief PowderJamp Pharma Corporation
Hot Lemon Relief Powder Extra StrengthNutralife Health Products Ltd.
Hot Lemon Relief Powder Regular StrengthNutralife Health Products Ltd.
Hot Lemon Relief Regular StrengthJamp Pharma Corporation
Hot Lemon Relief-extra Strength Pck-pwsApotex Inc
Hvp Chelated Cal/mag With Zinc and Vitamins C and DDarwen Holdings Ltd.
Hypo Vites TabPharmetics (2011) Inc
I-care Multivitamin and Multimineral TabletsPharmetics (2011) Inc
Iberet 500Abbott Laboratories, Limited
IcapsAlcon Canada Inc
Icaps Time ReleaseAlcon Canada Inc
ImedeenNordic Selfcare Institute P Technologies Int'l (Pti) Inc.
Imm FormulaAbundance Marketing Ltd.
Imm Formula CapNature's Sunshine Products Of Canada Ltd.
Inatal AdvanceNnodum Pharmaceuticals
Inatal UltraNnodum Pharmaceuticals
Infa Drops MultivitaminsVita Health Products Inc
Infant Multivitamin DropsGeneral Nutrition Canada Inc.
Infant's Multiple Vitamin DropsStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Infantol DropsChurch & Dwight Canada Corp
Infants' Vitamin DropsKsl Pharmaceuticals
Insur-all Vitamin SupplementGarden State Nutritionals
Integra FUs Pharmaceutical Corporation
Integra PlusUs Pharmaceutical Corporation
Iron 25mg With Vit B-cmplx, Vit C, Cu & MoQuest Vitamins A Div Of Purity Life Health Products
Iron ComplexPremier Plus Supplements Inc.
Iron Plus Manganese, B12, Folic Acid & CNatural Factors Nutritional Products Ltd.
Iron Plus TabSwiss Herbal Remedies Ltd.
Iron Polysaccharides Folic Acid DHAVirtus Pharmaceuticals LLC
Iron Vitamins B6,b12,c,folic Acid TabLaboratoire Lalco Inc.
Itabs PlusVita Health Products Inc
Kama Caze SyrupAlbi Naturals
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Ultra HrNatural Organics Inc.
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Vi-daylin Adc Vitamins Drops for InfantsAbbott Laboratories, Limited
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Vigo Multivitamins Drops/lozengeAshbury Research Corporation
Vimeral TabIcn Canada Ltd.
Virt-bal DHA PlusVirtus Pharmaceuticals
Virt-capsVirtus Pharmaceuticals LLC
Virt-PNVirtus Pharmaceuticals
Virt-PN DHAVirtus Pharmaceuticals
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Virt-vite PlusVirtus Pharmaceuticals LLC
Vit B Complex Plus Vit C 550mgHall Laboratories, Ltd.
Vit C Chew Tab 250mgHall Laboratories, Ltd.
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Vitachrom GcNikken Usa, Incorporated
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Vitaflex Dietary SuplementHome Shopping Network Direct
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Salts
Name/CASStructureProperties
Sodium ascorbate
ThumbNot applicableDBSALT001764
Categories
UNIIPQ6CK8PD0R
CAS number50-81-7
WeightAverage: 176.1241
Monoisotopic: 176.032087988
Chemical FormulaC6H8O6
InChI KeyCIWBSHSKHKDKBQ-JLAZNSOCSA-N
InChI
InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
IUPAC Name
(5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2,5-dihydrofuran-2-one
SMILES
[H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO
Pharmacology
IndicationUsed to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.
Structured Indications
PharmacodynamicsAscorbic Acid (vitamin C) is a water-soluble vitamin indicated for the prevention and treatment of scurvy, as ascorbic acid deficiency results in scurvy. Collagenous structures are primarily affected, and lesions develop in bones and blood vessels. Administration of ascorbic acid completely reverses the symptoms of ascorbic acid deficiency.
Mechanism of actionIn humans, an exogenous source of ascorbic acid is required for collagen formation and tissue repair by acting as a cofactor in the posttranslational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Ascorbic acid is reversibly oxidized to dehydroascorbic acid in the body. These two forms of the vitamin are believed to be important in oxidation-reduction reactions. The vitamin is involved in tyrosine metabolism, conversion of folic acid to folinic acid, carbohydrate metabolism, synthesis of lipids and proteins, iron metabolism, resistance to infections, and cellular respiration.
TargetKindPharmacological actionActionsOrganismUniProt ID
Prolyl 4-hydroxylase subunit alpha-1ProteinunknownNot AvailableHumanP13674 details
Solute carrier family 23 member 1ProteinunknownNot AvailableHumanQ9UHI7 details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1Proteinunknown
activator
HumanQ02809 details
Hyaluronate lyaseProteinunknownNot AvailableStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)Q54873 details
DNANucleotideunknownNot AvailableHumannot applicabledetails
Xylose isomeraseProteinunknownNot AvailableStreptomyces rubiginosusP24300 details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2ProteinunknownNot AvailableHumanO00469 details
Phytanoyl-CoA dioxygenase, peroxisomalProteinunknownNot AvailableHumanO14832 details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3ProteinunknownNot AvailableHumanO60568 details
Gamma-butyrobetaine dioxygenaseProteinunknownNot AvailableHumanO75936 details
Dopamine beta-hydroxylaseProteinunknownNot AvailableHumanP09172 details
Peptidyl-glycine alpha-amidating monooxygenaseProteinunknownNot AvailableHumanP19021 details
Prolyl 3-hydroxylase 1ProteinunknownNot AvailableHumanQ32P28 details
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2ProteinunknownNot AvailableHumanQ6N063 details
DNA oxidative demethylase ALKBH2ProteinunknownNot AvailableHumanQ6NS38 details
Prolyl 3-hydroxylase 2ProteinunknownNot AvailableHumanQ8IVL5 details
Prolyl 3-hydroxylase 3ProteinunknownNot AvailableHumanQ8IVL6 details
Prolyl 3-hydroxylase OGFOD1ProteinunknownNot AvailableHumanQ8N543 details
Egl nine homolog 2ProteinunknownNot AvailableHumanQ96KS0 details
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3ProteinunknownNot AvailableHumanQ96Q83 details
Lysine-specific demethylase 5DProteinunknownNot AvailableHumanQ9BY66 details
Egl nine homolog 1ProteinunknownNot AvailableHumanQ9GZT9 details
Egl nine homolog 3ProteinunknownNot AvailableHumanQ9H6Z9 details
Trimethyllysine dioxygenase, mitochondrialProteinunknownNot AvailableHumanQ9NVH6 details
Transmembrane prolyl 4-hydroxylaseProteinunknownNot AvailableHumanQ9NXG6 details
Lactase-phlorizin hydrolaseProteinunknownNot AvailableHumanP09848 details
Related Articles
Absorption70% to 90%
Volume of distributionNot Available
Protein binding25%
Metabolism

Hepatic. Ascorbic acid is reversibly oxidised (by removal of the hydrogen from the enediol group of ascorbic acid) to dehydroascorbic acid. The two forms found in body fluids are physiologically active. Some ascorbic acid is metabolized to inactive compounds including ascorbic acid-2-sulfate and oxalic acid.

SubstrateEnzymesProduct
Vitamin C
Not Available
Oxalic acidDetails
Vitamin C
Not Available
ascorbic acid-2-sulfateDetails
Route of eliminationNot Available
Half life16 days (3.4 hours in people who have excess levels of vitamin C)
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Catecholamine BiosynthesisMetabolicSMP00012
The oncogenic action of FumarateDiseaseSMP02295
Oxidation of Branched Chain Fatty AcidsMetabolicSMP00030
Aromatic L-Aminoacid Decarboxylase DeficiencyDiseaseSMP00170
The oncogenic action of SuccinateDiseaseSMP02292
Tyrosinemia Type IDiseaseSMP00218
Disulfiram Action PathwayDrug actionSMP00429
Carnitine SynthesisMetabolicSMP00465
Tyrosine hydroxylase deficiencyDiseaseSMP00497
Tyrosine MetabolismMetabolicSMP00006
Refsum DiseaseDiseaseSMP00451
Tyrosinemia, transient, of the newbornDiseaseSMP00494
AlkaptonuriaDiseaseSMP00169
HawkinsinuriaDiseaseSMP00190
Phytanic Acid Peroxisomal OxidationMetabolicSMP00450
Dopamine beta-hydroxylase deficiencyDiseaseSMP00498
Monoamine oxidase-a deficiency (MAO-A)DiseaseSMP00533
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
2,5-Dimethoxy-4-ethylamphetamineThe serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when it is combined with Vitamin C.Experimental, Illicit
3,4-MethylenedioxyamphetamineThe serum concentration of 3,4-Methylenedioxyamphetamine can be decreased when it is combined with Vitamin C.Experimental, Illicit
3,4-MethylenedioxymethamphetamineThe serum concentration of 3,4-Methylenedioxymethamphetamine can be decreased when it is combined with Vitamin C.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamineThe serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when it is combined with Vitamin C.Experimental, Illicit
Aluminum hydroxideVitamin C can cause an increase in the absorption of Aluminum hydroxide resulting in an increased serum concentration and potentially a worsening of adverse effects.Approved
AmphetamineThe serum concentration of Amphetamine can be decreased when it is combined with Vitamin C.Approved, Illicit
BazedoxifeneThe serum concentration of Bazedoxifene can be increased when it is combined with Vitamin C.Approved, Investigational
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with Vitamin C.Approved, Illicit
BortezomibThe therapeutic efficacy of Bortezomib can be decreased when used in combination with Vitamin C.Approved, Investigational
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be increased when it is combined with Vitamin C.Withdrawn
ChlorphentermineThe serum concentration of Chlorphentermine can be decreased when it is combined with Vitamin C.Illicit, Withdrawn
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Vitamin C.Approved
CopperThe serum concentration of Vitamin C can be decreased when it is combined with Copper.Approved
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with Vitamin C.Approved, Investigational, Vet Approved
DeferoxamineThe risk or severity of adverse effects can be increased when Vitamin C is combined with Deferoxamine.Approved, Investigational
DextroamphetamineThe serum concentration of Dextroamphetamine can be decreased when it is combined with Vitamin C.Approved, Illicit
DienestrolThe serum concentration of Dienestrol can be increased when it is combined with Vitamin C.Approved
DiethylpropionThe serum concentration of Diethylpropion can be decreased when it is combined with Vitamin C.Approved, Illicit
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Vitamin C.Approved
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Vitamin C.Approved, Investigational, Vet Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Vitamin C.Approved, Vet Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Vitamin C.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Vitamin C.Approved
GenisteinThe serum concentration of Genistein can be increased when it is combined with Vitamin C.Investigational
HexestrolThe serum concentration of Hexestrol can be increased when it is combined with Vitamin C.Withdrawn
Hydroxyamphetamine hydrobromideThe serum concentration of Hydroxyamphetamine hydrobromide can be decreased when it is combined with Vitamin C.Approved
LisdexamfetamineThe serum concentration of Lisdexamfetamine can be decreased when it is combined with Vitamin C.Approved, Investigational
MephedroneThe serum concentration of Mephedrone can be decreased when it is combined with Vitamin C.Investigational
MephentermineThe serum concentration of Mephentermine can be decreased when it is combined with Vitamin C.Approved
MestranolThe serum concentration of Mestranol can be increased when it is combined with Vitamin C.Approved
MethallenestrilThe serum concentration of Methallenestril can be increased when it is combined with Vitamin C.Experimental
MethamphetamineThe serum concentration of Methamphetamine can be decreased when it is combined with Vitamin C.Approved, Illicit
MMDAThe serum concentration of MMDA can be decreased when it is combined with Vitamin C.Experimental, Illicit
PhentermineThe serum concentration of Phentermine can be decreased when it is combined with Vitamin C.Approved, Illicit
Polyestradiol phosphateThe serum concentration of Polyestradiol phosphate can be increased when it is combined with Vitamin C.Approved
PromestrieneThe serum concentration of Promestriene can be increased when it is combined with Vitamin C.Investigational
PseudoephedrineThe serum concentration of Pseudoephedrine can be decreased when it is combined with Vitamin C.Approved
QuinestrolThe serum concentration of Quinestrol can be increased when it is combined with Vitamin C.Approved
RitobegronThe serum concentration of Ritobegron can be decreased when it is combined with Vitamin C.Investigational
S EquolThe serum concentration of S Equol can be increased when it is combined with Vitamin C.Investigational
SecoisolariciresinolThe serum concentration of Secoisolariciresinol can be increased when it is combined with Vitamin C.Investigational
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Vitamin C.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Vitamin C.Approved
TiboloneThe serum concentration of Tibolone can be increased when it is combined with Vitamin C.Approved
ZeranolThe serum concentration of Zeranol can be increased when it is combined with Vitamin C.Vet Approved
Food InteractionsNot Available
References
Synthesis Reference

Lewis D. Morse, Paul A. Hammes, “Beverage containing stabilized vitamin C and iron and method of making same.” U.S. Patent US3958017, issued October, 1972.

US3958017
General References
  1. Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH, Chen S, Corpe C, Dutta A, Dutta SK, Levine M: Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22(1):18-35. [PubMed:12569111 ]
  2. Meister A: Glutathione-ascorbic acid antioxidant system in animals. J Biol Chem. 1994 Apr 1;269(13):9397-400. [PubMed:8144521 ]
  3. Englard S, Seifter S: The biochemical functions of ascorbic acid. Annu Rev Nutr. 1986;6:365-406. [PubMed:3015170 ]
  4. Banhegyi G, Mandl J: The hepatic glycogenoreticular system. Pathol Oncol Res. 2001;7(2):107-10. [PubMed:11458272 ]
  5. Proctor P: Similar functions of uric acid and ascorbate in man? Nature. 1970 Nov 28;228(5274):868. [PubMed:5477017 ]
  6. Korcok J, Dixon SJ, Lo TC, Wilson JX: Differential effects of glucose on dehydroascorbic acid transport and intracellular ascorbate accumulation in astrocytes and skeletal myocytes. Brain Res. 2003 Dec 12;993(1-2):201-7. [PubMed:14642847 ]
External Links
ATC CodesNot Available
AHFS Codes
  • 88:04.00
  • 88:12.00
PDB Entries
FDA labelNot Available
MSDSDownload (74.6 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.6559
Blood Brain Barrier+0.8532
Caco-2 permeable-0.771
P-glycoprotein substrateNon-substrate0.6077
P-glycoprotein inhibitor INon-inhibitor0.9097
P-glycoprotein inhibitor IINon-inhibitor0.9807
Renal organic cation transporterNon-inhibitor0.9008
CYP450 2C9 substrateNon-substrate0.8133
CYP450 2D6 substrateNon-substrate0.8696
CYP450 3A4 substrateNon-substrate0.6361
CYP450 1A2 substrateNon-inhibitor0.8958
CYP450 2C9 inhibitorNon-inhibitor0.9478
CYP450 2D6 inhibitorNon-inhibitor0.9347
CYP450 2C19 inhibitorNon-inhibitor0.9383
CYP450 3A4 inhibitorNon-inhibitor0.9662
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9249
Ames testNon AMES toxic0.8941
CarcinogenicityNon-carcinogens0.9417
BiodegradationReady biodegradable0.9526
Rat acute toxicity1.3059 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9676
hERG inhibition (predictor II)Non-inhibitor0.9286
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
PowderOral
Injection, solutionIntramuscular; Intravenous; Subcutaneous500 mg/mL
Injection, solutionIntravenous500 mg/mL
SolutionIntramuscular; Intravenous500 mg
SolutionIntramuscular; Intravenous; Subcutaneous500 mg
PowderOral5 g
LiquidIntramuscular; Intravenous
ElixirOral
TabletOral166.7 mg
PowderTopical.375 g/75g
Powder, for solutionIntramuscular; Intravenous
Powder, for solutionIntravenous
TabletOral300 mg
TabletOral600 mg
Tablet, effervescentOral1000 mg
GranuleOral
PowderOral272 mg
TabletOral350 mg
TabletOral500 mg
WaferOral500 mg
LiquidOral50 mg
CapsuleOral375 mg
TabletOral333 mg
PowderOral825 mg
TabletOral5.7 mg
Solution / dropsOral50 mg
TabletOral
Capsule, extended releaseOral
CapsuleOral120 mg
WaferOral
Kit
CapsuleOral200 mg
Tablet, effervescentOral1 g
Powder, for solutionOral
Tablet, extended releaseOral
Tablet, film coatedOral
SyrupOral
PowderOral15 mg
TabletOral200 mg
TabletOral15 mg
TabletOral125 mg
Kit; powderOral
Kit; powder, for solutionOral
TabletOral750 mg
LiquidOral60 mg
Tablet, effervescentOral500 mg
LiquidOral250 mg
LiquidOral100 mg
Liquid; tabletOral
LiquidIntravenous
Injection, powder, lyophilized, for solutionIntravenous
LiquidIntramuscular; Intravenous; Subcutaneous500 mg
SolutionIntravenous250 mg
Tablet, chewableOral30 mg
Solution / dropsOral
SolutionIntravenous
Granule, effervescentOral
LiquidOral
SolutionOral
Tablet, chewableOral
Capsule, gelatin coatedOral
TabletOral250 mg
CapsuleOral660 mg
CapsuleOral
CapsuleOral25 mg
PowderOral1000 mg
LiquidTopical
TabletOral150 mg
Tablet, effervescentOral
PowderOral888.8 mg
Tablet, coatedOral
KitOral
KitOral30 mg
LozengeOral100 mg
CapsuleOral650 mg
TabletOral50 mg
CapsuleOral8 mg
Capsule; liquidOral
SolutionOral0.3 mg
Kit
Tablet, extended releaseOral1 g
LiquidOral550 mg
Capsule, liquid filledOral
LiquidIntramuscular; Intravenous250 mg
CapsuleOral1000 mg
CapsuleOral1 g
CapsuleOral100 mg
TabletOral1.5 g
CapsuleOral250 mg
TabletOral400 mg
TabletOral60 mg
GranuleOral1000 mg
PowderOral1.3 g
PowderOral100 %
PowderOral1200 mg
PowderOral2 g
PowderOral3 g
PowderOral4 g
Tablet, extended releaseOral1.8 g
PowderOral1250 mg
Capsule, extended releaseOral500 mg
TabletOral100 mg
TabletOral1000 mg
Tablet, extended releaseOral1.5 g
PowderOral1 g
Tablet, extended releaseOral1000 mg
TabletOral1 g
LiquidOral1 g
CapsuleOral150 mg
CapsuleOral500 mg
LiquidOral500 mg
Tablet, extended releaseOral500 mg
LozengeOral
Prices
Unit descriptionCostUnit
Cenolate 500 mg/1 ml ampul1.74USD ml
Cenolate 1 gm/2 ml ampul1.21USD ml
Calcium ascorbate powder0.79USD g
Ascorbic acid 222 mg/ml vial0.35USD ml
Ascor l 500 500 mg/ml vial0.24USD ml
Vitamin c 1500 mg tablet sa0.22USD tablet
CVS Pharmacy vit c ener boost 1000 mg0.21USD each
Cemill+bioflavonoids tablet0.09USD tablet
Vitamin c 1000 mg tablet sa0.09USD tablet
Cemill-1000 tablet0.08USD tablet
Vitamin c 1000 mg tablet0.08USD tablet
Cemill-500 tablet sa0.07USD tablet
CVS Pharmacy vitamin c 1000 mg tablet chw0.06USD tablet
Vitamin c 1000 mg caplet0.06USD caplet
Ascorbic acid 500 mg tablet0.04USD tablet
CVS Pharmacy vitamin c 1000 mg caplet0.04USD caplet
Pv ester-c 500 mg tablet0.04USD tablet
Vitamin c 500 mg chew tablet0.04USD tablet
Vitamin c 500 mg tablet0.04USD tablet
Vitamin c drops0.04USD tablet
Ra vitamin c cough drops0.03USD tablet
Vitamin c 250 mg tablet0.03USD tablet
Vitamin c 250 mg tablet chew0.03USD tablet
CVS Pharmacy vitamin c 500 mg caplet0.02USD caplet
CVS Pharmacy vitamin c 500 mg tablet0.02USD tablet
Ra vitamin c 100 mg tablet0.02USD tablet
Vicks vitamin c 60 mg drops0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7169381 No2004-09-012024-09-01Us
US7658914 No2004-09-012024-09-01Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point191 dec °CPhysProp
water solubility4E+005 mg/L (at 40 °C)MERCK INDEX (1996)
logP-1.85AVDEEF,A (1997)
pKa4.7 (at 10 °C)KORTUM,G ET AL (1961)
Predicted Properties
PropertyValueSource
Water Solubility245.0 mg/mLALOGPS
logP-1.6ALOGPS
logP-1.9ChemAxon
logS0.14ALOGPS
pKa (Strongest Acidic)4.36ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area107.22 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity37.03 m3·mol-1ChemAxon
Polarizability14.93 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (8.32 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as butenolides. These are dihydrofurans with a carbonyk group at the C2 carbon atom.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassDihydrofurans
Sub ClassFuranones
Direct ParentButenolides
Alternative Parents
Substituents
  • 2-furanone
  • Vinylogous acid
  • Alpha,beta-unsaturated carboxylic ester
  • Enoate ester
  • Secondary alcohol
  • Lactone
  • Enediol
  • Carboxylic acid ester
  • 1,2-diol
  • Oxacycle
  • Monocarboxylic acid or derivatives
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Primary alcohol
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Procollagen-proline 4-dioxygenase activity
Specific Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Gene Name:
P4HA1
Uniprot ID:
P13674
Molecular Weight:
61048.775 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-dependent l-ascorbate transmembrane transporter activity
Specific Function:
Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
Gene Name:
SLC23A1
Uniprot ID:
Q9UHI7
Molecular Weight:
64830.445 Da
References
  1. Kang JS, Kim HN, Jung da J, Kim JE, Mun GH, Kim YS, Cho D, Shin DH, Hwang YI, Lee WJ: Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane. J Invest Dermatol. 2007 Mar;127(3):698-706. Epub 2006 Sep 28. [PubMed:17008880 ]
  2. Johnston L, Laverty G: Vitamin C transport and SVCT1 transporter expression in chick renal proximal tubule cells in culture. Comp Biochem Physiol A Mol Integr Physiol. 2007 Mar;146(3):327-34. Epub 2006 Dec 5. [PubMed:17258485 ]
  3. Savini I, Rossi A, Pierro C, Avigliano L, Catani MV: SVCT1 and SVCT2: key proteins for vitamin C uptake. Amino Acids. 2008 Apr;34(3):347-55. Epub 2007 Jun 1. [PubMed:17541511 ]
  4. Perez MJ, Castano B, Gonzalez-Buitrago JM, Marin JJ: Multiple protective effects of melatonin against maternal cholestasis-induced oxidative stress and apoptosis in the rat fetal liver-placenta-maternal liver trio. J Pineal Res. 2007 Sep;43(2):130-9. [PubMed:17645691 ]
  5. Steiling H, Longet K, Moodycliffe A, Mansourian R, Bertschy E, Smola H, Mauch C, Williamson G: Sodium-dependent vitamin C transporter isoforms in skin: Distribution, kinetics, and effect of UVB-induced oxidative stress. Free Radic Biol Med. 2007 Sep 1;43(5):752-62. Epub 2007 May 10. [PubMed:17664139 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
activator
General Function:
Protein homodimerization activity
Specific Function:
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Gene Name:
PLOD1
Uniprot ID:
Q02809
Molecular Weight:
83549.55 Da
References
  1. Salavoura K, Valari M, Kolialexi A, Mavrou A, Kitsiou S: A case of Ehlers Danlos syndrome type VI. Genet Couns. 2006;17(3):291-4. [PubMed:17100196 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Pharmacological action
unknown
General Function:
Hyaluronate lyase activity
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q54873
Molecular Weight:
120770.645 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Li S, Taylor KB, Kelly SJ, Jedrzejas MJ: Vitamin C inhibits the enzymatic activity of Streptococcus pneumoniae hyaluronate lyase. J Biol Chem. 2001 May 4;276(18):15125-30. Epub 2001 Jan 12. [PubMed:11278838 ]
  4. Okorukwu ON, Vercruysse KP: Effects of ascorbic acid and analogs on the activity of testicular hyaluronidase and hyaluronan lyase on hyaluronan. J Enzyme Inhib Med Chem. 2003 Aug;18(4):377-82. [PubMed:14567553 ]
  5. Botzki A, Rigden DJ, Braun S, Nukui M, Salmen S, Hoechstetter J, Bernhardt G, Dove S, Jedrzejas MJ, Buschauer A: L-Ascorbic acid 6-hexadecanoate, a potent hyaluronidase inhibitor. X-ray structure and molecular modeling of enzyme-inhibitor complexes. J Biol Chem. 2004 Oct 29;279(44):45990-7. Epub 2004 Aug 18. [PubMed:15322107 ]
5. DNA
Kind
Nucleotide
Organism
Human
Pharmacological action
unknown
General Function:
Used for biological information storage.
Specific Function:
DNA contains the instructions needed for an organism to develop, survive and reproduce.
Molecular Weight:
2.15 x 1012 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Guarnieri S, Loft S, Riso P, Porrini M, Risom L, Poulsen HE, Dragsted LO, Moller P: DNA repair phenotype and dietary antioxidant supplementation. Br J Nutr. 2008 May;99(5):1018-24. Epub 2007 Oct 10. [PubMed:17925050 ]
  4. Singh S, Rana SV: Amelioration of arsenic toxicity by L-Ascorbic acid in laboratory rat. J Environ Biol. 2007 Apr;28(2 Suppl):377-84. [PubMed:17929753 ]
  5. Manna P, Sinha M, Sil PC: Protection of arsenic-induced hepatic disorder by arjunolic acid. Basic Clin Pharmacol Toxicol. 2007 Nov;101(5):333-8. [PubMed:17910617 ]
Kind
Protein
Organism
Streptomyces rubiginosus
Pharmacological action
unknown
General Function:
Xylose isomerase activity
Specific Function:
Involved in D-xylose catabolism.
Gene Name:
xylA
Uniprot ID:
P24300
Molecular Weight:
43226.915 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Procollagen-lysine 5-dioxygenase activity
Specific Function:
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Gene Name:
PLOD2
Uniprot ID:
O00469
Molecular Weight:
84685.07 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Phytanoyl-coa dioxygenase activity
Specific Function:
Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.
Gene Name:
PHYH
Uniprot ID:
O14832
Molecular Weight:
38538.065 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Procollagen-lysine 5-dioxygenase activity
Specific Function:
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Gene Name:
PLOD3
Uniprot ID:
O60568
Molecular Weight:
84784.505 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
Gene Name:
BBOX1
Uniprot ID:
O75936
Molecular Weight:
44714.6 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Dunn WA, Rettura G, Seifter E, Englard S: Carnitine biosynthesis from gamma-butyrobetaine and from exogenous protein-bound 6-N-trimethyl-L-lysine by the perfused guinea pig liver. Effect of ascorbate deficiency on the in situ activity of gamma-butyrobetaine hydroxylase. J Biol Chem. 1984 Sep 10;259(17):10764-70. [PubMed:6432788 ]
  4. Vaz FM, van Gool S, Ofman R, IJlst L, Wanders RJ: Carnitine biosynthesis. Purification of gamma-butyrobetaine hydroxylase from rat liver. Adv Exp Med Biol. 1999;466:117-24. [PubMed:10709635 ]
  5. Rebouche CJ: Ascorbic acid and carnitine biosynthesis. Am J Clin Nutr. 1991 Dec;54(6 Suppl):1147S-1152S. [PubMed:1962562 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
L-ascorbic acid binding
Specific Function:
Conversion of dopamine to noradrenaline.
Gene Name:
DBH
Uniprot ID:
P09172
Molecular Weight:
69064.45 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Suzuki E, Kurata T, Shibata M, Mori M, Arakawa N: Activities of D- and L-xyloascorbic acid and D- and L-araboascorbic acid as a cofactor for dopamine beta-hydroxylase reaction. J Nutr Sci Vitaminol (Tokyo). 1997 Oct;43(5):491-6. [PubMed:9505234 ]
  4. Pettingill TM, Strange RW, Blackburn NJ: Carbonmonoxy dopamine beta-hydroxylase. Structural characterization by Fourier transform infrared, fluorescence, and x-ray absorption spectroscopy. J Biol Chem. 1991 Sep 15;266(26):16996-7003. [PubMed:1894598 ]
  5. Feng J, Shi J, Sirimanne SR, Mounier-Lee CE, May SW: Kinetic and stereochemical studies on novel inactivators of C-terminal amidation. Biochem J. 2000 Sep 1;350 Pt 2:521-30. [PubMed:10947967 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
Gene Name:
PAM
Uniprot ID:
P19021
Molecular Weight:
108331.35 Da
References
  1. Romero I, Teresa Sanchez-Ballesta M, Maldonado R, Isabel Escribano M, Merodio C: Anthocyanin, antioxidant activity and stress-induced gene expression in high CO2-treated table grapes stored at low temperature. J Plant Physiol. 2008;165(5):522-30. Epub 2007 Jun 13. [PubMed:17570561 ]
  2. Floryszak-Wieczorek J, Milczarek G, Arasimowicz M, Ciszewski A: Do nitric oxide donors mimic endogenous NO-related response in plants? Planta. 2006 Nov;224(6):1363-72. Epub 2006 Jun 14. [PubMed:16773376 ]
  3. Crespo A, Marti MA, Roitberg AE, Amzel LM, Estrin DA: The catalytic mechanism of peptidylglycine alpha-hydroxylating monooxygenase investigated by computer simulation. J Am Chem Soc. 2006 Oct 4;128(39):12817-28. [PubMed:17002377 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protein complex binding
Specific Function:
Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts.
Gene Name:
P3H1
Uniprot ID:
Q32P28
Molecular Weight:
83393.195 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Specific Function:
Not Available
Gene Name:
OGFOD2
Uniprot ID:
Q6N063
Molecular Weight:
38996.065 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Ferrous iron binding
Specific Function:
Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
Gene Name:
ALKBH2
Uniprot ID:
Q6NS38
Molecular Weight:
29322.22 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Procollagen-proline 3-dioxygenase activity
Specific Function:
Shows prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types II, IV and V.
Gene Name:
P3H2
Uniprot ID:
Q8IVL5
Molecular Weight:
80983.685 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Procollagen-proline 3-dioxygenase activity
Specific Function:
Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types IV and V.
Gene Name:
P3H3
Uniprot ID:
Q8IVL6
Molecular Weight:
81835.705 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Peptidyl-proline dioxygenase activity
Specific Function:
Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit RPS23, thereby regulating protein translation termination efficiency. Involved in stress granule formation.
Gene Name:
OGFOD1
Uniprot ID:
Q8N543
Molecular Weight:
63245.655 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Peptidyl-proline 4-dioxygenase activity
Specific Function:
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HI...
Gene Name:
EGLN2
Uniprot ID:
Q96KS0
Molecular Weight:
43650.03 Da
References
  1. Nytko KJ, Spielmann P, Camenisch G, Wenger RH, Stiehl DP: Regulated function of the prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins. Antioxid Redox Signal. 2007 Sep;9(9):1329-38. [PubMed:17627474 ]
  2. Bruegge K, Jelkmann W, Metzen E: Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-alpha hydroxylases. Curr Med Chem. 2007;14(17):1853-62. [PubMed:17627521 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
L-ascorbic acid binding
Specific Function:
Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular ...
Gene Name:
ALKBH3
Uniprot ID:
Q96Q83
Molecular Weight:
33374.495 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis.
Gene Name:
KDM5D
Uniprot ID:
Q9BY66
Molecular Weight:
174071.34 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Peptidyl-proline dioxygenase activity
Specific Function:
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HI...
Gene Name:
EGLN1
Uniprot ID:
Q9GZT9
Molecular Weight:
46020.585 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Peptidyl-proline 4-dioxygenase activity
Specific Function:
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HI...
Gene Name:
EGLN3
Uniprot ID:
Q9H6Z9
Molecular Weight:
27261.06 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Trimethyllysine dioxygenase activity
Specific Function:
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Gene Name:
TMLHE
Uniprot ID:
Q9NVH6
Molecular Weight:
49517.2 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Specific Function:
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Gene Name:
P4HTM
Uniprot ID:
Q9NXG6
Molecular Weight:
56660.535 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Transferase activity
Specific Function:
LPH splits lactose in the small intestine.
Gene Name:
LCT
Uniprot ID:
P09848
Molecular Weight:
218584.77 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-dependent l-ascorbate transmembrane transporter activity
Specific Function:
Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
Gene Name:
SLC23A1
Uniprot ID:
Q9UHI7
Molecular Weight:
64830.445 Da
References
  1. Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA: A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature. 1999 May 6;399(6731):70-5. [PubMed:10331392 ]
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Drug created on June 13, 2005 07:24 / Updated on December 03, 2016 02:45