Progressive autonomic failure

Also known as: PURE AUTONOMIC FAILURE / Autonomic failure syndrome / Shy-Drager syndrome / Autonomic failure progressive

DrugDrug NameDrug Description
DB06262DroxidopaDroxidopa is a precursor of noradrenaline that is used in the treatment of Parkinsonism. It is approved for use in Japan and is currently in trials in the U.S. The racaemic form (dl-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. There is a deficit of noradrenaline as well as of dopamine in Parkinson's disease and it has been proposed that this underlies the sudden transient freezing seen usually in advanced disease. Though L-DOPS has been used in Japan and Southeast Asia already for some time, it is also currently in clinical trials at the phase III point in the United States (U.S.), Canada, Australia, and throughout Europe. Provided L-DOPS successfully completes clinical trials, it could be approved for the treatment of neurogenic orthostatic hypotension (NOH) as early as 2011. Additionally, phase II clinical trials for intradialytic hypotension are also underway. Chelsea Therapeutics obtained orphan drug status (ODS) for L-DOPS in the U.S. for NOH, and that of which associated with Parkinson's disease , pure autonomic failure, and multiple system atrophy, and is the pharmaceutical company developing it in that country.
DrugDrug NamePhaseStatusCount
DB09153Sodium Chloride0Recruiting1
DB12054BQ-1231Recruiting1
DB01197Captopril1Completed1
DB06262Droxidopa1Recruiting1
DB00678Losartan1Completed1
DB00211Midodrine1Recruiting2
DB00852Pseudoephedrine1Completed1
DB01116Trimethaphan1Completed1
DB06262Droxidopa3Terminated1
DB00742Mannitol3Terminated1
DB00264MetoprololNot AvailableCompleted1
DB04861NebivololNot AvailableCompleted1
DB00203SildenafilNot AvailableCompleted1
DB11815TilarginineNot AvailableCompleted1
DB01116TrimethaphanNot AvailableCompleted1