Nucleoside diphosphate kinase A

Details

Name
Nucleoside diphosphate kinase A
Synonyms
  • 2.7.4.6
  • GAAD
  • Granzyme A-activated DNase
  • Metastasis inhibition factor nm23
  • NDK A
  • NDPKA
  • NM23
  • NM23-H1
  • Tumor metastatic process-associated protein
Gene Name
NME1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006062|Nucleoside diphosphate kinase A
MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPF
FAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGS
DSVESAEKEIGLWFHPEELVDYTSCAQNWIYE
Number of residues
152
Molecular Weight
17148.635
Theoretical pI
6.11
GO Classification
Functions
ATP binding / deoxyribonuclease activity / GTP binding / identical protein binding / magnesium ion binding / nucleoside diphosphate kinase activity / poly(A) RNA binding / ribosomal small subunit binding
Processes
cell differentiation / CTP biosynthetic process / DNA metabolic process / endocytosis / GTP biosynthetic process / negative regulation of cell proliferation / nervous system development / nucleobase-containing small molecule interconversion / nucleobase-containing small molecule metabolic process / nucleoside triphosphate biosynthetic process / positive regulation of DNA binding / positive regulation of epithelial cell proliferation / purine nucleotide metabolic process / pyrimidine nucleotide metabolic process / regulation of apoptotic process / small molecule metabolic process / UTP biosynthetic process
Components
cytoplasm / cytosol / extracellular exosome / intracellular / membrane / nucleus / ruffle membrane
General Function
Ribosomal small subunit binding
Specific Function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0021353|Nucleoside diphosphate kinase A (NME1)
ATGGCCAACTGTGAGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTT
GTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTGGTCTGAAATTC
ATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTC
TTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGG
CTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAG
CCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGAACATTATACATGGCAGT
GATTCTGTGGAGAGTGCAGAGAAGGAGATCGGCTTGTGGTTTCACCCTGAGGAACTGGTA
GATTACACGAGCTGTGCTCAGAACTGGATCTATGAATGA
Chromosome Location
17
Locus
17q21.3
External Identifiers
ResourceLink
UniProtKB IDP15531
UniProtKB Entry NameNDKA_HUMAN
GenBank Gene IDX75598
GenAtlas IDNME1
HGNC IDHGNC:7849
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB021812'-Deoxyguanosine-5'-TriphosphateexperimentalunknownDetails
DB02345SelenocysteineexperimentalunknownDetails
DB025692',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-DiphosphateexperimentalunknownDetails
DB02607Adenosine Phosphonoacetic AcidexperimentalunknownDetails
DB028872',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-TriphosphateexperimentalunknownDetails
DB03103Thymidine-5'- DiphosphateexperimentalunknownDetails
DB034912'-Deoxyguanosine-5'-DiphosphateexperimentalunknownDetails
DB04068FudpexperimentalunknownDetails
DB043663'-Deoxy 3'-Amino Adenosine-5'-DiphosphateexperimentalunknownDetails
DB045423'-Azido-3'-Deoxythymidine-5'-DiphosphateexperimentalunknownDetails
DB04315Guanosine-5'-DiphosphateexperimentalunknownDetails
DB00709Lamivudineapproved, investigationalunknownsubstrateDetails
DB00718Adefovir dipivoxilapproved, investigationalunknownsubstrateDetails
DB08934SofosbuvirapprovedunknownsubstrateDetails
DB09130Copperapproved, investigationalunknownDetails
DB01593Zincapproved, investigationalunknownDetails
DB14487Zinc acetateapproved, investigationalunknownDetails
DB14533Zinc chlorideapproved, investigationalunknownDetails
DB09299Tenofovir alafenamideapprovednosubstrateDetails
DB14126Tenofovirexperimental, investigationalnosubstrateDetails
DB00300Tenofovir disoproxilapproved, investigationalunknownsubstrateDetails
DB00787AcyclovirapprovedyessubstrateDetails