Adenosine - DrugBank

ID Pharmacology Interactions References Trials Economics Properties Spectra Taxonomy

Targets (4)Enzymes (2)Transporters (1)

Targets (4)Enzymes (2)Transporters (1)Biointeractions (6)

Identification

Name

Adenosine

Accession Number

DB00640 (APRD00132)

Type

Small Molecule

Groups

Approved, Investigational

Description

A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. [PubChem]

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

6-Amino-9-beta-D-ribofuranosyl-9H-purine

9-beta-D-Ribofuranosidoadenine

9-beta-D-Ribofuranosyl-9H-purin-6-amine

Ade-rib

Adenin riboside

Adenine deoxyribonucleoside

Adenocard

Adenocor

Adenoscan

Adenosin

Adenosina

Adénosine

Adenosinum

Adenyldeoxyriboside

Ado

beta-D-Adenosine

Deoxyadenosine

Desoxyadenosine

External IDs

SR 96225 / USAF CB-10

Product Ingredients

Not Available

Approved Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Adenocard	Solution	6 mg/2mL	Intravenous	Cardinal Health	1989-10-30	Not applicable	US
Adenocard	Solution	3 mg/mL	Intravenous	Cardinal Health	1989-10-30	Not applicable	US
Adenocard	Solution	3 mg/mL	Intravenous	Remedy Repack	2015-08-18	Not applicable	US
Adenocard	Solution	3 mg/mL	Intravenous	Astellas Pharma Inc	1989-10-30	Not applicable	US
Adenocard - Liq Rapid Bolus IV 3mg/ml	Solution	3 mg	Intravenous	Astellas Pharma Inc	1996-08-14	2014-12-05	Canada
Adenocard Injection -pre-filled Syringe	Solution	3 mg	Intravenous	Astellas Pharma Inc	1994-12-31	Not applicable	Canada
Adenocard Liq IV 3mg/ml	Liquid	3 mg	Intravenous	Fujisawa Pharmaceutical Co, Division Of Fujisawa Canada Inc.	1993-12-31	1996-09-09	Canada
Adenocard Liq IV 3mg/ml (pre-filled Syringe)	Liquid	3 mg	Intravenous	Fujisawa Pharmaceutical Co, Division Of Fujisawa Canada Inc.	1994-12-31	1996-09-09	Canada
Adenoscan	Solution	3 mg/mL	Intravenous	Remedy Repack	2013-06-10	2016-10-13	US
Adenoscan	Solution	3 mg/mL	Intravenous	Astellas Pharma Inc	1995-05-18	Not applicable	US
Adenoscan	Solution	3 mg/mL	Intravenous	Remedy Repack	2013-06-27	2017-04-14	US
Adenoscan - (for IV Infusion Only)	Solution	3 mg	Intravenous	Astellas Pharma Inc	1995-12-31	2009-05-29	Canada
Adenosine Injection	Solution	3 mg	Intravenous	Fresenius Kabi	2007-03-27	Not applicable	Canada
Adenosine Injection	Solution	3 mg	Intravenous	Fresenius Kabi	Not applicable	Not applicable	Canada
Adenosine Injection	Solution	3 mg	Intravenous	Fresenius Kabi	Not applicable	Not applicable	Canada
Adenosine Injection, USP	Solution	3 mg	Intravenous	Mylan Pharmaceuticals	Not applicable	Not applicable	Canada
Adenosine Injection, USP	Solution	3 mg	Intravenous	Mylan Pharmaceuticals	Not applicable	Not applicable	Canada
Aj-adenosine	Solution	3 mg	Intravenous	Agila Jamp Canada Inc	Not applicable	Not applicable	Canada
Aj-adenosine	Solution	3 mg	Intravenous	Agila Jamp Canada Inc	Not applicable	Not applicable	Canada
PMS-adenosine	Solution	3 mg	Intravenous	Pharmascience Inc	2001-06-07	Not applicable	Canada

Approved Generic Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Adenosine	Injection, solution	3 mg/mL	Intravenous	Akorn	2014-10-02	Not applicable	US
Adenosine	Injection	3 mg/mL	Intravenous	General Injectables & Vaccines	2014-03-26	2017-02-09	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	AGILA SPECIALTIES PRIVATE LIMITED	2014-03-22	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Hospira, Inc.	2014-03-24	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Heritage	2014-08-01	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Physicians Total Care, Inc.	2006-03-16	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Sagent Pharmaceuticals	2014-03-28	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Heritage	2014-08-01	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Cardinal Health	2011-03-17	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Remedy Repack	2016-06-07	2017-02-15	US
Adenosine	Injection	3 mg/mL	Intravenous	West Ward Pharmaceutical	2004-06-16	Not applicable	US
Adenosine	Injection	3 mg/mL	Intravenous	Sagent Pharmaceuticals	2009-09-01	Not applicable	US
Adenosine	Injection	3 mg/mL	Intravenous	Wockhardt	2009-07-20	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Teva Parenteral Medicines, Inc.	2013-09-23	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Baxter Laboratories	2010-04-20	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Remedy Repack	2013-07-16	2016-12-31	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Fresenius Kabi	2005-11-23	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Teva Parenteral Medicines, Inc.	2013-09-23	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Akorn	2011-03-15	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Remedy Repack	2014-05-23	2016-12-16	US
Adenosine	Injection	3 mg/mL	Intravenous	Wockhardt	2009-07-20	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	General Injectables & Vaccines	2011-10-05	Not applicable	US

Approved Over the Counter Products

Not Available

Unapproved/Other Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
A.H.c Real Eye for Face	Cream	.12 mg/30mL	Topical	Carver Korea Co.,Ltd.	2013-06-21	Not applicable	US
A.H.C. Collagen Cream	Cream	20 mg/50mL	Topical	Carver Korea Co.,Ltd.	2013-08-15	Not applicable	US
A.H.C. Collagen Toner	Liquid	48 mg/120mL	Topical	Carver Korea Co.,Ltd.	2013-08-15	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Cantrell Drug Company	2015-02-05	Not applicable	US
Advanced Snail 92 All In One Cream	Cream	.04 mg/100mL	Topical	Cosrx Inc.	2016-05-24	Not applicable	US
Ahc Collagen Serum	Liquid	12 mg/30mL	Topical	Carver Korea Co.,Ltd.	2013-08-15	Not applicable	US
Ahc Complex Choice Egf Booster	Cream	.4 mg/mL	Topical	Carver Korea Co.,Ltd.	2013-08-15	Not applicable	US
Ahc Complex Choice Egf Booster	Cream	.4 mg/mL	Topical	Carver Korea Co.,Ltd.	2013-08-15	Not applicable	US
Ahc Hydration Special Gen Cream	Cream	20 mg/50mL	Topical	Carver Korea Co.,Ltd.	2013-07-15	Not applicable	US
Ahc Hydration Special Gen Mask	Liquid	12.8 mg/32g	Topical	Carver Korea Co.,Ltd.	2013-07-15	Not applicable	US
Ahc Hydration Special Gen Serum	Liquid	12 mg/30mL	Topical	Carver Korea Co.,Ltd.	2013-07-15	Not applicable	US
Ahc Hydration Special Gen Solution	Liquid	54 mg/135mL	Topical	Carver Korea Co.,Ltd.	2013-07-15	Not applicable	US
Ahc Phyto Complex Mask	Liquid	12 mg/30g	Topical	Carver Korea Co.,Ltd.	2016-10-20	Not applicable	US
Ahc Vital C Complex Mask	Liquid	12 mg/30g	Topical	Carver Korea Co.,Ltd.	2013-08-15	Not applicable	US
An Adc Sp F	Solution	2.8 mg/7mL	Topical	An Co Ltd.	2016-05-01	Not applicable	US
Antibe Super Hydrating Moisturizing Cream	Cream	.04 g/100mL	Topical	Modongee Co., Ltd.	2015-07-01	Not applicable	US
Applicell Essential Toner	Liquid	.05 g/130mL	Topical	Anc Hn B Inc.	2016-10-10	Not applicable	US
Applicell Intensive Serum	Cream	.01 g/45mL	Topical	Anc Hn B Inc.	2016-10-10	Not applicable	US
Applicell Miracle	Cream	.02 g/50mL	Topical	Anc Hn B Inc.	2016-10-10	Not applicable	US
Applicell Perfect Eye	Cream	.01 g/30mL	Topical	Anc Hn B Inc.	2016-10-10	Not applicable	US
Applicell Timeless Ampoule	Solution	1.2 mg/3mL	Topical	Anc Hn B Inc.	2016-10-10	Not applicable	US
Aqua Collagen Coenzyme Q10 Hydro Mask	Patch	.008 g/20g	Topical	Nature Republic Co., Ltd.	2015-02-01	Not applicable	US
Aqua Collagen Solu Tion Coenzyme Q10 Hydroge L Mask	Patch	.008 g/20g	Topical	Nature Republic Co., Ltd.	2015-02-01	Not applicable	US
B.S.c Ampul	Liquid	.6 mg/6mL	Topical	Cellcos Inc	2013-01-30	Not applicable	US
Bellaskin Skin-rebirth Contour	Cream	.04 mL/100mL	Topical	Ajou Medics Co., Ltd	2011-09-13	Not applicable	US
Benton Fermentation Eye 10g	Cream	.004 g/10g	Topical	Benton Korea	2016-08-01	Not applicable	US
Brucke Keep Cooling Foilgel Lifting Mask	Liquid	.04 g/100g	Topical	Nature4 Co., Ltd.	2017-04-12	Not applicable	US
Capture Hyaluronic Ampoule	Liquid	20 mg/50mL	Topical	Carver Korea Co.,Ltd.	2013-07-05	Not applicable	US
Caviall Perfect Repair Serum	Gel	.04 g/100mL	Topical	C&bcosmetic Co.,ltd.	2017-03-10	Not applicable	US
Caviallcrystal	Cream	.04 g/100g	Topical	C&bcosmetic Co.,ltd.	2017-02-16	Not applicable	US
Complete Choice Moisture Amploule	Liquid	6 mg/15mL	Topical	Carver Korea Co.,Ltd.	2013-07-05	Not applicable	US
Dcs Merderm Jeju Lava Seawater	Cream	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2016-12-01	Not applicable	US
Dcs Merderm Jeju Lava Seawater Ampoule	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2016-12-01	Not applicable	US
Dcs Merderm Jeju Lava Seawater Eye	Cream	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-01-06	Not applicable	US
Dcs Merderm Jeju Lava Seawater Toner	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2016-12-01	Not applicable	US
Deepair Micro Intensive Magic	Cream	.04 g/100mL	Topical	Acosmetic. co.ltd	2016-08-01	Not applicable	US
Dr. Althea Pore-control Charcoal Mask	Liquid	.04 g/100g	Topical	Dr. Althea	2016-12-01	Not applicable	US
Dr. Althea Water Glow Aqua Ampoule Mask	Liquid	.04 g/100g	Topical	Dr. Althea	2016-12-01	Not applicable	US
Dr. Gloderm Tabrx Wrinkletox	Cream	.0428 g/100g	Topical	Dr.gloderm	2017-03-01	Not applicable	US
Dr. Gloderm Tabrx Wrinkletox Mask	Kit		Topical	Dr.gloderm	2017-03-23	Not applicable	US
Dr. Gloderm Time To Wrinkletox Mask	Liquid	.04 g/100mL	Topical	Dr.gloderm	2017-03-01	Not applicable	US
Dr.eslee Triple Action Bb	Cream	.2 g/100g	Topical	Ajou Medics Co., Ltd	2011-09-13	Not applicable	US
Drh T Stem Cell	Cream	.02 g/50g	Topical	New & New Co.,ltd.	2016-10-01	Not applicable	US
Drh T Stem Cell	Liquid	2 mg/5mL	Topical	New & New Co.,ltd.	2016-10-01	Not applicable	US
Edge Cutimal Tiger Anti-wrinkle Mask	Patch	.01 g/25g	Topical	Oneskin Cosmetics Co., Ltd.	2016-11-01	Not applicable	US
Elcure Aout Rose	Liquid	.04 mL/100mL	Topical	Elcure Co., Ltd.	2011-08-22	2017-05-24	US
Elcure Q Serum	Liquid	25 mg/50mL	Topical	Elcure Co., Ltd.	2013-07-18	2017-04-21	US
Herb Blending	Emulsion	.06 g/150mL	Topical	Nature Republic Co., Ltd.	2017-04-01	Not applicable	US
Herb Blending	Cream	.012 g/30mL	Topical	Nature Republic Co., Ltd.	2017-04-01	Not applicable	US
Herb Blending Essence	Liquid	.02 g/50mL	Topical	Nature Republic Co., Ltd.	2017-04-01	Not applicable	US
Herb Blending Toner	Liquid	.06 g/150mL	Topical	Nature Republic Co., Ltd.	2017-04-01	Not applicable	US
Iaso A5 Super Brightening Formula	Cream	.0004 mL/mL	Topical	Iaso Inc	2010-12-21	Not applicable	US
Iaso Pregressive Age Care Eye	Cream	.0004 g/g	Topical	Iaso Inc	2011-01-09	Not applicable	US
Iaso Progressive Age Care	Cream	.0004 g/g	Topical	Iaso Inc	2011-01-09	Not applicable	US
Iaso Progressive Age Care Emulsion	Cream	.0004 mL/mL	Topical	Iaso Inc	2011-01-01	Not applicable	US
Iaso Progressive Age Care Serum	Cream	.0004 mL/mL	Topical	Iaso Inc	2011-01-09	Not applicable	US
Iaso Progressive Age Care Toner	Liquid	.0004 mL/mL	Topical	Iaso Inc	2011-01-01	Not applicable	US
Iaso Triple Protection Bb SPF 30 Pa	Cream	.0004 g/g	Topical	Iaso Inc	2011-01-09	Not applicable	US
Jejuen Aloe Soothing Extreme Micro Silky Mask	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-21	Not applicable	US
Jejuen Black Bean Ferment	Cream	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-16	Not applicable	US
Jejuen Black Bean Ferment	Emulsion	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-16	Not applicable	US
Jejuen Black Bean Ferment Toner	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-16	Not applicable	US
Jejuen Camellia Wrinkle Care Extreme Micro Silky Mask	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-21	Not applicable	US
Jejuen Hyaluron Waterful Extreme Micro Silky Mask	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-01	Not applicable	US
Jejuen Rape Flower Shining Extreme Micro Silky Mask	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-01	Not applicable	US
Jejuen Volcanic Pore Zero Extreme Micro Silky Mask	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-01	Not applicable	US
Lovely Geranium Aromatherapy Mask	Patch	.5 g/25g	Topical	Aroma Yong	2017-04-01	2017-05-24	US
Lovely Geranium Aromatherapy Mask	Patch	.01 g/25g	Topical	Aroma Yong	2017-05-01	Not applicable	US
Mamachi Moms Stretch Mark Cream	Cream	6 g/150g	Topical	Supio Co,. Ltd.	2014-05-01	Not applicable	US
Manefit Beauty Planner Blackberry Firming Eye Mask	Cream	.004 mg/10g	Topical	Imine Co., Ltd.	2016-03-04	Not applicable	US
Manefit Beauty Planner Lavender Wrinkle Lifting Mask	Cream	.08 mg/20mL	Topical	Imine Co., Ltd.	2014-07-17	Not applicable	US
Mefactory 3step Piggy Nose Pore Strip Step 01 Pore Opening Sheet	Patch	.6 mg/3g	Topical	Me Factory Co., Ltd.	2017-02-01	Not applicable	US
Mioggi Healing Effector Rx Collagenic	Cream	.02 mg/50mL	Topical	Colorpink R&D Inc.	2012-08-20	Not applicable	US
Mioggi Magic Advanced Skin Essential Activator	Liquid	.05 mg/125mL	Topical	Colorpink R&D Inc.	2012-08-20	Not applicable	US
Misoli Power Snail and Collagen Hydrog El Mask Pack	Patch	.014 g/35g	Topical	Jt Co., Ltd.	2016-10-10	Not applicable	US
Niveola 3d Animal Cat Mask Pack	Cream	.01 g/27g	Topical	Unisource International Co., Ltd.	2015-10-08	Not applicable	US
Niveola 3d Animal Dog Mask Pack	Cream	.01 g/27g	Topical	Unisource International Co., Ltd.	2015-10-08	Not applicable	US
Nmc Magic Serum	Liquid	.04 mg/100mL	Topical	Nmc (Natural Magma Cosmetics)	2013-07-11	Not applicable	US
Nmc Staypot Double Programing Cream	Liquid	.04 mg/100mL	Topical	Nmc (Natural Magma Cosmetics)	2013-07-11	Not applicable	US
Nots Li P Shimmer Gloss	Lipstick	.001 g/3.5g	Topical	No Ts Co.,Ltd	2016-07-01	Not applicable	US
Oozoo Face Ampoule Alpha One Hydro Lift	Liquid	.00012 mg/.3mL	Topical	Outin Futures Corp.	2016-01-21	2016-10-13	US
Oozoo Face Ampoule Alpha One Nutrient	Cream	.00012 mg/.3mL	Topical	Outin Futures Corp.	2016-01-22	2016-10-13	US
Oozoo Face Mask Alpha One Hydro Lift	Cream	.011 mg/27mL	Topical	Outin Futures Corp.	2016-01-20	2016-10-13	US
Oozoo Face Mask Alpha One Illumination Ampoule	Cream	.00012 mg/.3mL	Topical	Outin Futures Corp.	2016-01-31	2016-10-13	US
Oozoo Face Mask Alpha One Illumination Mask	Cream	.011 mg/27mL	Topical	Outin Futures Corp.	2016-01-31	2016-10-13	US
Oozoo Face Mask Alpha One Illumination Serum	Cream	.001 mg/2.5mL	Topical	Outin Futures Corp.	2016-01-31	2016-10-13	US
Oozoo Face Mask Alpha One Nutirient	Cream	.011 mg/27mL	Topical	Outin Futures Corp.	2016-01-22	2016-10-13	US
Oozoo Face Serum Alpha One Hydro Lift	Cream	.001 mg/2.5mL	Topical	Outin Futures Corp.	2016-01-21	2016-10-13	US
Oozoo Face Serum Alpha One Nutrient	Cream	.001 mg/2.5mL	Topical	Outin Futures Corp.	2016-01-22	2016-10-13	US
Perfect V Lifting Premium Mask	Liquid	.04 g/100g	Topical	Avajar Co Ltd	2017-01-01	Not applicable	US
Primerose Snail	Cream	.0004 1/100mL	Topical	Royal Springs Cosmetics Usa, Llc	2015-06-04	Not applicable	US
Purifying Skin Balancing	Cream	.04 g/100mL	Topical	In This Morning	2017-02-08	Not applicable	US
Sallys Box Gold Snail Hydrogel Mask	Cream	.01 g/25g	Topical	Imine Co., Ltd.	2015-01-05	Not applicable	US
Shieldlife Collagen Ion Mask	Patch	1 g/100g	Topical	Orion Electronics Inc.	2016-09-13	Not applicable	US
Skinfood Gold Caviar Collagen Serum	Cream	.018 g/45mL	Topical	Skinfood Co., Ltd.	2011-03-01	Not applicable	US
Skinfood Gold Caviar Serum	Cream	.018 g/45mL	Topical	Skinfood Co., Ltd.	2011-03-01	Not applicable	US
Skinfood Royal Honey Essential Eye	Cream	.012 g/30mL	Topical	Skinfood Co., Ltd.	2016-04-01	Not applicable	US
Skinfood Royal Honey Essential Eye Individual Sample	Cream	.4 mg/g	Topical	Skinfood Co., Ltd.	2016-04-01	Not applicable	US
Stem Cell Renew	Cream	.04 mL/mL	Topical	Medon Co., Ltd	2011-04-06	Not applicable	US
Stem Cell Wrinkle Serum	Liquid	.0004 mL/mL	Topical	Medon Co., Ltd	2011-04-06	Not applicable	US
The Oozoo Face Gold Foilayer Mask	Patch	.01 g/25mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Face Silver Foilayer Mask	Patch	.01 g/25mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Lightening Cap Sule Activator	Liquid	.001 g/4mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Lightening Mask	Patch	.008 g/20mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Oozoo Bear Aurora Illuminating Ampoule	Liquid	.001 g/3mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Oozoo Bear Aurora Illuminating Mask	Patch	.009 g/24mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Oozoo Bear Black Space Pore Caring Ampoule	Liquid	.001 g/3mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Oozoo Bear Black Space Pore Caring Mask	Patch	.009 g/24mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Oozoo Bear Water Bang Hydrating Ampoule	Liquid	.001 g/3mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Oozoo Bear Water Bang Hydrating Mask	Patch	.008 g/20mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Recovery Cap Sule Activator	Liquid	.001 g/4mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Recovery Mask	Patch	.008 g/20mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
Tosowoong Mens Booster Repair	Lotion	1 mg/150mL	Topical	Mantong	2013-07-05	Not applicable	US
U-max Wrinkle Serum	Liquid	.04 mL/100mL	Topical	VS Shinbi Co., Ltd.	2012-06-04	Not applicable	US
Ultimate Moisturizing Honey Overnight Mask	Cream	.02 g/50g	Topical	Cosrx Inc.	2016-05-23	2016-11-08	US
Ultimate Moisturizing Honey Overnight Mask	Cream	.024 g/60g	Topical	Cosrx Inc.	2016-05-23	Not applicable	US
Yenaan Jinaek	Emulsion	.06 g/150mL	Topical	Yenaan Cosmetics	2017-03-02	Not applicable	US
Yenaan Jinaek Toner	Liquid	.06 g/150mL	Topical	Yenaan Cosmetics	2017-03-02	Not applicable	US

International Brands

Name	Company
Adenocor	Sanofi-Aventis
Adenoject	Sun
Adenoz	Celon
Adenozer	Purzer
Adesin	Dae Han New Pharm
Adrekar	Sanofi-Aventis
Atépadène	Mayoly-Spindler
Cardimax	AC Farma
Cardiovert	Sanofi-Aventis
Krenosin	Sanofi-Aventis
Osiden	Square
Pisdeno	Pisa

Brand mixtures

Name	Labeller	Ingredients
Abalone Aqua Flood Water	C&bcosmetic Co.,ltd.	Adenosine Nicotinamide
Abalone Crystaldouble EX	C&bcosmetic Co.,ltd.	Adenosine Nicotinamide
Abalone Crystaldouble EX Ampoule	C&bcosmetic Co.,ltd.	Adenosine Arbutin
Abalone Crystaldouble EX Bb	C&bcosmetic Co.,ltd.	Adenosine Nicotinamide Octinoxate Octocrylene Titanium dioxide
Abalone Crystaldouble EX Cc	C&bcosmetic Co.,ltd.	Adenosine Nicotinamide Octinoxate Titanium dioxide
Abalone Crystaldouble EX Homme	C&bcosmetic Co.,ltd.	Adenosine Nicotinamide
Abalone Crystaldouble EX Serum	C&bcosmetic Co.,ltd.	Adenosine Nicotinamide
Absolute Total Bb Spf37 Pa 3plus	Wizcoz Corporation Ltd	Adenosine Arbutin Titanium dioxide Zinc oxide
Ahc Premium Intense Contour Balm	Carver Korea Co.,Ltd.	Adenosine Aluminum hydroxide Aluminum stearate Arbutin Methicone (20 cst) Octinoxate Talc Titanium dioxide Zinc oxide
Ahc Revitalizing Special Gen Cream	Carver Korea Co.,Ltd.	Adenosine Nicotinamide
Ahc Revitalizing Special Gen Mask	Carver Korea Co.,Ltd.	Adenosine Nicotinamide
Ahc Revitalizing Special Gen Serum	Carver Korea Co.,Ltd.	Adenosine Nicotinamide
Ahc Revitalizing Special Gen Solution	Carver Korea Co.,Ltd.	Adenosine Nicotinamide
Ahc Vital Complex C-15 Ampoule	Carver Korea Co.,Ltd.	Adenosine Arbutin
Allvit Revital Up	Coway Co., Ltd.	Adenosine Nicotinamide
Antibe Beausenne Special Ampoule	Modongee Co., Ltd.	Adenosine Nicotinamide
Atono2 Oxygen Mothers Cream	Laorganic Co., Ltd.	Adenosine Nicotinamide
Birds Nest Forever Young Multi Care Lifting	F&Co Co., Ltd.	Adenosine Nicotinamide
Brucke A.C.C. Cure Ampoule	Nature4 Co., Ltd.	Adenosine Nicotinamide
Brucke Keep Cooling Hydrogel Soothing Mask	Nature4 Co., Ltd.	Adenosine Nicotinamide
Camellia Air Cushion 21 Spf50 Pa	Tov Co., Ltd	Adenosine Nicotinamide Titanium dioxide
Camellia Air Cushion 22 Spf50 Pa	Tov Co., Ltd	Adenosine Nicotinamide Titanium dioxide
Camellia Calming Sleeping Mask	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Camellia Cc Cream 21 Spf45 Pa	Tov Co., Ltd	Adenosine Nicotinamide Titanium dioxide
Camellia Cc Cream 22 Spf45 Pa	Tov Co., Ltd	Adenosine Nicotinamide Titanium dioxide
Camellia Cooling Cc 21 Spf50 Pa	Tov Co., Ltd	Adenosine Nicotinamide Titanium dioxide
Camellia Cooling Cc 22 Spf50 Pa	Tov Co., Ltd	Adenosine Nicotinamide Titanium dioxide
Camellia Vital Dual Serum	Tov Co., Ltd	Adenosine Nicotinamide
Camellia Wrinkle Free Eye	Tov Co., Ltd	Adenosine Nicotinamide
Capture Collagen Ampoule	Carver Korea Co.,Ltd.	Adenosine Nicotinamide
Caviall Real Caviar Multi-perfection O2 Serum	C&bcosmetic Co.,ltd.	Adenosine Nicotinamide
Centella 70	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Centella 80 Eye	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Centella 90 Ampoule	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Centella and Green Tea Callus Mask	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Centella Reviving Toner	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Conju Princess Bb	Conju Inc	Adenosine Arbutin Titanium dioxide
D-one By Tamdoan Bb Light	Dran Co.,ltd	Adenosine Arbutin Diethylamino hydroxybenzoyl hexyl benzoate Octinoxate Octisalate Octocrylene Titanium dioxide Zinc oxide
D-one By Tamdoan Bb Medium	Dran Co.,ltd	Adenosine Arbutin Diethylamino hydroxybenzoyl hexyl benzoate Octinoxate Octisalate Octocrylene Titanium dioxide Zinc oxide
D-one By Tamdoan Sunscreen 50	Dran Co.,ltd	Adenosine Arbutin Diethylamino hydroxybenzoyl hexyl benzoate Octinoxate Octisalate Octocrylene Titanium dioxide Zinc oxide
Derma Blemish Balm Blemish Balm	Universal Cosmetic Co., Ltd	Adenosine Arbutin Titanium dioxide
Doctorslab Returning Platinum Mask	Nature & Nature Co., Ltd.	Adenosine Nicotinamide
Dr Deep Aqua Wrinklecream	Mineral House Corporation	Adenosine Allantoin
Dr G Dewrinkle Booster Ample By Egf	The Doctor's Cosmetic Inc	Adenosine Glycerin
Dr G Dewrinkle Fortifier By Egf	The Doctor's Cosmetic Inc	Adenosine Glycerin
Dr G Dewrinkle Reformer By Egf	The Doctor's Cosmetic Inc	Adenosine Dimethicone
Dr. Gloderm Tabrx Liftup	Dr.gloderm	Adenosine Nicotinamide
Dr. Gloderm Tabrx Liftup Mask	Dr.gloderm	Adenosine Nicotinamide
Dr. Gloderm Time To Liftup Mask	Dr.gloderm	Adenosine Nicotinamide
Dr. Pepti Centella Toner	J&coceu Co Ltd	Adenosine Nicotinamide
Dr. Pepti Intensive	J&coceu Co Ltd	Adenosine Nicotinamide
Dr.althea Aurora Cover Cushion 21	Dr. Althea	Adenosine Nicotinamide Octinoxate Octisalate Octocrylene Titanium dioxide Zinc oxide
Dr.g Brightening Up Cushion Spf50 Plus Pa Plus Plus Plus	GOWOONSESANG COSMETICS CO., LTD.	Adenosine Nicotinamide Titanium dioxide
Drh Whitening G2	New & New Co.,ltd.	Adenosine Arbutin
Galactomyces 70	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Galactomyces 80 Contouring Eye	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Galactomyces 90 Ampoule	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Galactomyces 95 Whitening Power Essence	Cosrx Inc.	Adenosine Nicotinamide
Galactomyces and Rice Callus Mask	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Galactomyces First Essence	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Galactomyces Radiance Toner	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Ginseng	Synbio Co., Ltd.	Adenosine Nicotinamide
Ginseng Berry 80 Eye Essence	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Ginseng Berry 80 Overnight Mask	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Ginseng Berry and Ginseng Callus Mask	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Ginseng Royal Silk 120ml	Nature Republic Co., Ltd.	Adenosine Nicotinamide
Ginseng Royal Silk Ampoule 17ml 4ea	Nature Republic Co., Ltd.	Adenosine Nicotinamide
Ginseng Royal Silk Boosting Ampoule	Nature Republic Co., Ltd.	Adenosine Nicotinamide
Ginseng Royal Silk Cap Sule Essence	Nature Republic Co., Ltd.	Adenosine Nicotinamide
Ginseng Royal Silk Eye 25ml	Nature Republic Co., Ltd.	Adenosine Nicotinamide
Ginseng Royal Silk Gold Hydroge L Mask	Nature Republic Co., Ltd.	Adenosine Nicotinamide
Ginseng Royal Silk Gold Hydroge L Mask 10p	Nature Republic Co., Ltd.	Adenosine Nicotinamide
Ginseng Royal Silk Gold Hydroge L Mask 5p	Nature Republic Co., Ltd.	Adenosine Nicotinamide
Ginseng Royal Silk Toner 120ml	Nature Republic Co., Ltd.	Adenosine Nicotinamide
Ginseng Royal Silk Watery 60g	Nature Republic Co., Ltd.	Adenosine Nicotinamide
Ginseng Royal Silk Wrinkle Up Spot	Nature Republic Co., Ltd.	Adenosine Nicotinamide
Green Propolis 90 Ampoule	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Hanskin Bio Origin The	Celltrion Skincure Co.,ltd.	Adenosine Nicotinamide
Hello Care Anti-wrinkle Ampoule Mask	World Pack Co., Ltd.	Adenosine Nicotinamide
Hello Care Moisturizing Ampoule Mask	World Pack Co., Ltd.	Adenosine Nicotinamide
Hello Care Pore and Sebum Ampoule Mask	World Pack Co., Ltd.	Adenosine Nicotinamide
Hello Care Whitening Ampoule Mask	World Pack Co., Ltd.	Adenosine Nicotinamide
Honesi Exofila	Originway Co., Ltd.	Adenosine Nicotinamide
Hydra Extra Concentrateserum	In This Morning	Adenosine Nicotinamide
Hydra Moisture Day and Night	In This Morning	Adenosine Nicotinamide
Ideal Tone Up Glow Bb	In This Morning	Adenosine Nicotinamide Titanium dioxide Zinc oxide
Jayjun Real Water Brightening Black Mask Step2 Jayjun Vita Snow Essence	Jayjun Cosmetic	Adenosine Allantoin Glycerin Nicotinamide
Jayjun Real Water Brightening Black Mask Step3 Real Water Brightening Black Mask	Jayjun Cosmetic	Adenosine Allantoin Glycerin Nicotinamide
Lip and Hand Camellia	Tov Co., Ltd	Adenosine Nicotinamide
Lip and Hand Shea Butter	Tov Co., Ltd	Adenosine Nicotinamide
Lip and Hand Wild Rose	Tov Co., Ltd	Adenosine Nicotinamide
Maxclinic Deep and Deeper Meso Change Ampoule	N&b lab.co.ltd	Adenosine Nicotinamide
Maxclinic Miraclinic Contour Ing Object	N&b lab.co.ltd	Adenosine Nicotinamide
Medi Hydro Dp B Tox Ampoule	Mbg Inc (Korea Institute of Science Development)	Adenosine Nicotinamide
Medi Hydro Dp Bb Cream	Mbg Inc (Korea Institute of Science Development)	Adenosine Aluminum hydroxide Nicotinamide Stearic acid Titanium dioxide
Medi Hydro Dp Cream	Mbg Inc (Korea Institute of Science Development)	Adenosine Nicotinamide
Medi Hydro Dp Emulsion	Mbg Inc (Korea Institute of Science Development)	Adenosine Nicotinamide
Medi Hydro Dp Stem C Ampoule	Mbg Inc (Korea Institute of Science Development)	Adenosine Nicotinamide
Medi Hydro Dp Toner	Mbg Inc (Korea Institute of Science Development)	Adenosine Nicotinamide
Medi Hydro Dp Vita C Ampoule	Mbg Inc (Korea Institute of Science Development)	Adenosine Nicotinamide
Miesoo Perfect Pure Seed	C&bcosmetic Co.,ltd.	Adenosine Nicotinamide
Miesoo Perfect Pure Seed Cycling Ampoule	C&bcosmetic Co.,ltd.	Adenosine Nicotinamide
Miesoo Perfect Pure Seed Essence	C&bcosmetic Co.,ltd.	Adenosine Nicotinamide
Miesoo Perfect Pure Seed Toner	C&bcosmetic Co.,ltd.	Adenosine Nicotinamide
Mu Lab Turn Around 2w Refresh EX	Mu biz.co,.ltd	Adenosine Nicotinamide
Natural Sun AQ Total Anti-aging Essence Sun	Thefaceshop Co., Ltd.	Adenosine Avobenzone Enzacamene Nicotinamide Octinoxate Octisalate Titanium dioxide
Neogen Agecure 3d Lifting Compression Span Tex Mask	Outin Futures Corp.	Adenosine Nicotinamide
Neogen Agecure 3d Lifting Wrinkle Neck Mask	Outin Futures Corp.	Adenosine Nicotinamide
Neogen Agecure One Minute Wrinkle Rx	Outin Futures Corp.	Adenosine Nicotinamide
Neogen Code9 Gold Black Caviar Essence	Outin Futures Corp.	Adenosine Nicotinamide
Neogen Code9 Lemon Green Caviar Essence	Outin Futures Corp.	Adenosine Nicotinamide
Neogen Dermalogy H2 Dermadeca Serum	Outin Futures Corp.	Adenosine Nicotinamide
Neogen Dermalogy Pink Cactus Liftmax Knit Mask	Outin Futures Corp.	Adenosine Nicotinamide
Neogen Dermalogy White Truffle Hydramax Knit Mask	Outin Futures Corp.	Adenosine Nicotinamide
Neogen Dermalogy White Truffle Serum In Oi L Drop	Outin Futures Corp.	Adenosine Nicotinamide
Nots Special Collagen Real Skin Mask	No Ts Co.,Ltd	Adenosine Glycerin
P1p Chitosan V-mask	Phytos Co., Ltd.	Adenosine Nicotinamide Panthenol
P1p Magic Whitening Antiaging	Phytos Co., Ltd.	Adenosine Nicotinamide Panthenol
P1p Skin Rebirth Cream	Phytos Co., Ltd.	Adenosine Dimethicone
Plalab Placenta Ample Essence	Renocell Co., Ltd	Adenosine Nicotinamide
Plalab Placenta Mask	Renocell Co., Ltd	Adenosine Nicotinamide
Plalab Placenta R-20	Renocell Co., Ltd	Adenosine Nicotinamide
Plalab Placenta Skin Booster	Renocell Co., Ltd	Adenosine Nicotinamide
Premium Dr. Althea Power Whitening Glutathione Mask	Dr. Althea	Adenosine Nicotinamide
Premium Dr. Althea Water Glow Skin Renewal Hydrogel Mask	Dr. Althea	Adenosine Nicotinamide
Prestige Caviar Full Intensive Vitality Toner	Fw1 R&D Branch	Adenosine Nicotinamide
Prestige Caviar Super Aqua Serum	Fw1 R&D Branch	Adenosine Nicotinamide
Prestige Snail Repairing	Zenpia	Adenosine Nicotinamide
Prestige Snail Repairing Ampoule	Zenpia	Adenosine Nicotinamide
Prestige Snail Repairing Booster	Zenpia	Adenosine Nicotinamide
Primerose Double Effect Eye	Royal Springs Cosmetics Usa, Llc	Adenosine Nicotinamide
Primerose Egf	Royal Springs Cosmetics Usa, Llc	Adenosine Dimethicone Nicotinamide
Primerose White Milky Cb	Royal Springs Cosmetics Usa, Llc	Adenosine Dimethicone Nicotinamide Panthenol
Propolis 20 Bb Cream	Ami Cosmetic Co.,Ltd.	Adenosine Arbutin Octinoxate Octisalate Titanium dioxide
Propolis 27 Cover Cushion	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide Octinoxate Octisalate Octocrylene Titanium dioxide Zinc oxide
Propolis 50 Volume Mist	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide Propolis wax
Propolis 80	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide Propolis wax
Propolis 80 Sleeping Pack	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide Propolis wax
Propolis and Rose Callus Mask	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Propolis Softening Toner	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide Propolis wax
Protective Base Sun for Dry Skin	In This Morning	Adenosine Nicotinamide Titanium dioxide Zinc oxide
Protective Base Sun for Oily Skin	In This Morning	Adenosine Nicotinamide Titanium dioxide Zinc oxide
Pure C Serum	R&L Co., Ltd.	Adenosine Nicotinamide
Queens Rose Recovery	Cdpharmtec Co.,ltd	Adenosine Nicotinamide
Queens Rose Recovery Eye	Cdpharmtec Co.,ltd	Adenosine Nicotinamide
Queens Rose Recovery Toner	Cdpharmtec Co.,ltd	Adenosine Nicotinamide
Rep Nutrinature Ultra All In One Multitem	Outin Futures Corp.	Adenosine Nicotinamide
Rep Nutrinature Ultra Moist Ge L	Outin Futures Corp.	Adenosine Nicotinamide
Rep Nutrinature Ultra Moist Gel Oil	Outin Futures Corp.	Adenosine Nicotinamide
Rep Nutrinature Ultra Nourishing	Outin Futures Corp.	Adenosine Nicotinamide
Rep Nutrinature Ultra Nourishing Cream	Outin Futures Corp.	Adenosine Nicotinamide
Rep Nutrinature Ultra-all-night Moisture Relief Mask	Outin Futures Corp.	Adenosine Nicotinamide
Rose Oasis 50 Moisture Bomb	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Rose Oasis 70 Cream	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Rose Oasis 80 Ampoule	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Ruby Cell 4u	Dasan E&T Co., Ltd.	Adenosine Nicotinamide
Ruby Cell 4u Ampoule	Dasan E&T Co., Ltd.	Adenosine Nicotinamide
Ruby Cell 4u Ampoule Premium	Dasan E&T Co., Ltd.	Adenosine Nicotinamide
Sheza Gusl Firming Mask Pack	Pisatap	Adenosine Nicotinamide
Siseundeusi Luminant	Gk Cosmetic Co., Ltd.	Adenosine Nicotinamide
Siseundeusi Luminant Skin Toner	Gk Cosmetic Co., Ltd.	Adenosine Nicotinamide
Skin-ion	Wako Korea Corp	Adenosine Arbutin Glycerin
Skinfood Miracle Food 10 Solu Tion	Skinfood Co., Ltd.	Adenosine Glycerin Nicotinamide
Skinfood Miracle Food 10 Solu Tion 1ml	Skinfood Co., Ltd.	Adenosine Glycerin Nicotinamide
Skinfood Real Tea Ge L Mask Chamomile	Skinfood Co., Ltd.	Adenosine Glycerin Nicotinamide
Skinfood Real Tea Ge L Mask Lavender	Skinfood Co., Ltd.	Adenosine Glycerin Nicotinamide
Skinfood Real Tea Ge L Mask Rose	Skinfood Co., Ltd.	Adenosine Glycerin Nicotinamide
Snail Skin Booster	Nature Republic Co., Ltd.	Adenosine Nicotinamide
Snail Solu Tion Skin Booster	Nature Republic Co., Ltd.	Adenosine Nicotinamide
Snail Solu Tion Wrinkle Up Spot	Nature Republic Co., Ltd.	Adenosine Nicotinamide
Super Plus Beblesh Balm Triple Functions Spf50 Plus Pa 3plus (40g)	Wizcoz Corporation Ltd	Adenosine Amiloxate Arbutin Octinoxate Titanium dioxide Zinc oxide
Superplus Beblesh Balm Gold Spf25 Pa 2plus	Wizcoz Corporation Ltd	Adenosine Arbutin Titanium dioxide Zinc oxide
Superplus Beblesh Balm Spf25 Pa 2plus	Wizcoz Corporation Ltd	Adenosine Arbutin Titanium dioxide Zinc oxide
Superplus Beblesh Balm Triple Functions Spf25 Pa 2plus	Wizcoz Corporation Ltd	Adenosine Arbutin Octinoxate Octisalate Titanium dioxide Zinc oxide
Tamhada Synergy Anti Wrinkle Face and Neck Mask	Taenam Medicos Co., Ltd	Adenosine Glycerin
Tangerine Bright Sleeping Mask	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Thanks 12 Rich Caviar Mask	Hyundai Ibt Co., Ltd.	Adenosine Allantoin Glycerin Nicotinamide
Thanks 12 Rich Caviar Mist	Hyundai Ibt Co., Ltd.	Adenosine Allantoin Nicotinamide
The All Medicare V Pla Synergy Anti Wrinkle Face and Neck Mask	Taenam Medicos Co., Ltd	Adenosine Glycerin
The Barafu Intensive Serum	Bioresource Co., Ltd	Adenosine Allantoin Dexpanthenol
The Oozoo Face Energy Shot Premium Black Ampoule1	The Oozoo Co. Ltd	Adenosine Nicotinamide
The Oozoo Face Energy Shot Premium Black Ampoule2	The Oozoo Co. Ltd	Adenosine Nicotinamide
The Oozoo Face Energy Shot Premium Black Mask	The Oozoo Co. Ltd	Adenosine Nicotinamide
The Oriental Gold Bb Spf25 Pa 2plus	Wizcoz Corporation Ltd	Adenosine Arbutin Titanium dioxide Zinc oxide
The Prestige Bb Spf25 Pa 2plus	Wizcoz Corporation Ltd	Adenosine Arbutin Titanium dioxide Zinc oxide
Vita Volu 101 Essence	B&p Cosmetic, Inc.	Adenosine Dexpanthenol Nicotinamide
Vita Volu Volume Booster	B&p Cosmetic, Inc.	Adenosine Nicotinamide
Vitabrid C12 Face 4g	Hyundai Ibt Co., Ltd.	Adenosine Allantoin Nicotinamide
Vitabrid C12 Face Brightening	Hyundai Ibt Co., Ltd.	Adenosine Allantoin Nicotinamide
Vitabrid C12 Face Pow Der 2g	Hyundai Ibt Co., Ltd.	Adenosine Allantoin Nicotinamide
Vitabrid C12 Face Pow Der 3g	Hyundai Ibt Co., Ltd.	Adenosine Allantoin Arbutin
Vitabrid C12 Sensitive Spot Pow Der Serum	Hyundai Ibt Co., Ltd.	Adenosine Nicotinamide
Volcanic Grape Callus Mask	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Volcanic Homme	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Volcanic Homme All In One Essence	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Volcanic Homme Toner	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Volcanic Pore Eraser Ampoule	Ami Cosmetic Co.,Ltd.	Adenosine Nicotinamide
Wellage Deep Layer Fresh Moisture	Hugel Pharma Co.,Ltd.	Adenosine Nicotinamide
Wellage Fresh Water Essence Mist	Hugel Pharma Co.,Ltd.	Adenosine Nicotinamide
White Lie	Samsung Cosmetics Co., Ltd.	Adenosine Nicotinamide
Yenaan Jinaek	Yenaan Cosmetics	Adenosine Nicotinamide
Yenaan Jinaek Essence	Yenaan Cosmetics	Adenosine Nicotinamide
Yenaan Jinaek Eye	Yenaan Cosmetics	Adenosine Nicotinamide

Categories

UNII

K72T3FS567

CAS number

58-61-7

Weight

Average: 267.2413
Monoisotopic: 267.096753929

Chemical Formula

C₁₀H₁₃N₅O₄

InChI Key

OIRDTQYFTABQOQ-KQYNXXCUSA-N

InChI

InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1

IUPAC Name

(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

SMILES

NC1=C2N=CN([C@@H]3O[[email protected]](CO)[C@@H](O)[[email protected]]3O)C2=NC=N1

Pharmacology

Indication

Used as an initial treatment for the termination of paroxysmal supraventricular tachycardia (PVST), including that associated with accessory bypass tracts, and is a drug of choice for terminating stable, narrow-complex supraventricular tachycardias (SVT). Also used as an adjunct to thallous chloride TI 201 myocardial perfusion scintigraphy (thallium stress test) in patients who are unable to exercise adequately, as well as an adjunct to vagal maneuvers and clinical assessment to establish a specific diagnosis of undefined, stable, narrow-complex SVT.

Structured Indications

Pharmacodynamics

Adenosine is an endogenous nucleoside occurring in all cells of the body and is not chemically related to other antiarrhythmic drugs. Adenosine may exert its pharmacologic effects by activation of purine (cell surface A₁ and A₂ adenosine) receptors, as well as relax vascular smooth muscles through the reduction in calcium uptake by inhibition of slow inward calcium current and activation of adenylate cyclase in smooth muscle cells. Adenosine may reduce vascular tone by modulation of sympathetic neurotransmission. The drug also has negative chronotropic, dromotropic, and inotropic effects on the heart by slowing conduction time throught he AV node and interrupting AV nodal reentry pathways. Adenosine is a potent vasodilator in most vascular beds, but vasoconstriction is produced in renal afferent arterioles and hepatic veins. The drug produces a net mild to moderate reduction in systolic, diastolic, and mean arterial blood pressure and a reflex increase in heart rate. Adenosine is antagonized competitively by methylxanthines such as caffeine and theophylline, and potentiated by blockers of nucleoside transport such as dipyridamole. Adenosine is not blocked by atropine.

Mechanism of action

Adenosine slows conduction time through the AV node and can interrupt the reentry pathways through the AV node, resulting in the restoration of normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT), including PSVT associated with Wolff-Parkinson-White Syndrome. This effect may be mediated through the drug's activation of cell-surface A₁ and A₂ adenosine receptors. Adenosine also inhibits the slow inward calcium current and activation of adenylate cyclase in smooth muscle cells, thereby causing relaxation of vascular smooth muscle. By increasing blood flow in normal coronary arteries with little or no increase in stenotic arteries (with little to no increase in stenotic arteries), adenosine produces a relative difference in thallous (thallium) chloride TI 201 uptake in myocardium supplied by normal verus stenotic coronary arteries.

Target	Kind	Pharmacological action	Actions	Organism	UniProt ID
Adenosine receptor A2a	Protein	yes	agonist	Human	P29274	details
Adenosine receptor A2b	Protein	yes	agonist	Human	P29275	details
Adenosine receptor A3	Protein	yes	agonist	Human	P0DMS8	details
Adenosine receptor A1	Protein	yes	agonist	Human	P30542	details

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Intracellular adenosine is rapidly metabolized either via phosphorylation to adenosine monophosphate by adenosine kinase, or via deamination to inosine by adenosine deaminase in the cytosol.

Substrate	Enzymes	Product
Adenosine	Not Available	Adenosine monophosphate	Details
Adenosine	Not Available	Inosine	Details

Route of elimination

Not Available

Half life

Less than 10 secs

Clearance

Not Available

Toxicity

Not Available

Affected organisms

Humans and other mammals

Pathways

Pathway	Category	SMPDB ID
Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)	Disease	SMP00340
Lesch-Nyhan Syndrome (LNS)	Disease	SMP00364
Myoadenylate deaminase deficiency	Disease	SMP00537
Betaine Metabolism	Metabolic	SMP00123
Cystathionine Beta-Synthase Deficiency	Disease	SMP00177
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine	Signaling	SMP00320
Gout or Kelley-Seegmiller Syndrome	Disease	SMP00365
Azathioprine Action Pathway	Drug action	SMP00427
Xanthinuria type II	Disease	SMP00513
AICA-Ribosiduria	Disease	SMP00168
Mercaptopurine Action Pathway	Drug action	SMP00428
Thioguanine Action Pathway	Drug action	SMP00430
Xanthinuria type I	Disease	SMP00512
Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type	Disease	SMP00570
Adenylosuccinate Lyase Deficiency	Disease	SMP00167
Molybdenum Cofactor Deficiency	Disease	SMP00203
Purine Nucleoside Phosphorylase Deficiency	Disease	SMP00210
S-Adenosylhomocysteine (SAH) Hydrolase Deficiency	Disease	SMP00214
Glycine N-methyltransferase Deficiency	Disease	SMP00222
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine	Signaling	SMP00321
Adenine phosphoribosyltransferase deficiency (APRT)	Disease	SMP00535
Mitochondrial DNA depletion syndrome	Disease	SMP00536
Selenoamino Acid Metabolism	Metabolic	SMP00029
Methionine Metabolism	Metabolic	SMP00033
Purine Metabolism	Metabolic	SMP00050
Adenosine Deaminase Deficiency	Disease	SMP00144
Xanthine Dehydrogenase Deficiency (Xanthinuria)	Disease	SMP00220
Methionine Adenosyltransferase Deficiency	Disease	SMP00221
Hypermethioninemia	Disease	SMP00341

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

Drug	Interaction	Drug group
Ambroxol acefyllinate	The therapeutic efficacy of Adenosine can be decreased when used in combination with Ambroxol acefyllinate.	Experimental
Aminophylline	The therapeutic efficacy of Adenosine can be decreased when used in combination with Aminophylline.	Approved
Caffeine	The therapeutic efficacy of Adenosine can be decreased when used in combination with Caffeine.	Approved
Carbamazepine	The risk or severity of adverse effects can be increased when Carbamazepine is combined with Adenosine.	Approved, Investigational
Digoxin	The risk or severity of adverse effects can be increased when Digoxin is combined with Adenosine.	Approved
Dipyridamole	The risk or severity of adverse effects can be increased when Dipyridamole is combined with Adenosine.	Approved
Dyphylline	The therapeutic efficacy of Adenosine can be decreased when used in combination with Dyphylline.	Approved
Nicotine	Nicotine may increase the atrioventricular blocking (AV block) activities of Adenosine.	Approved
Theophylline	The therapeutic efficacy of Adenosine can be decreased when used in combination with Theophylline.	Approved

Food Interactions

Avoid caffeine containing foods and drinks.

References

Synthesis Reference

Giorgio Stramentinoli, Federico Gennari, “Process for preparing adenosine derivatives of anti-inflammatory and analgesic activity.” U.S. Patent US4373097, issued October, 1965.

US4373097

General References

Not Available

External Links

Resource	Link
Human Metabolome Database (HMDB)	HMDB00050
KEGG Drug	D00045
KEGG Compound	C00212
PubChem Compound	60961
PubChem Substance	46508728
ChemSpider	54923
BindingDB	14487
ChEBI	16335
ChEMBL	CHEMBL477
Therapeutic Targets Database	DAP000223
PharmGKB	PA448049
HET	ADN
Drug Product Database	4732
RxList	http://www.rxlist.com/cgi/generic3/adenos.htm
Drugs.com	http://www.drugs.com/cdi/adenosine.html
Wikipedia	Adenosine

ATC Codes

C01EB10

AHFS Codes

92:00.00

PDB Entries

Not Available

FDA label

Download (154 KB)

MSDS

Download (72.7 KB)

Clinical Trials

Phase	Status	Purpose	Conditions	Count
0	Completed	Basic Science	Blood Pressures / Cognition	1
0	Completed	Diagnostic	Myocardial Ischemia / Vascular Diseases	1
1	Completed	Not Available	Coronary Artery Disease	1
1	Completed	Treatment	Atrioventricular Block / Sinus Bradycardia	1
1	Terminated	Other	Inflammatory processes	1
1	Unknown Status	Diagnostic	Coronary Artery Disease	1
1, 2	Completed	Treatment	Adenosine / Cardiac Surgical Procedures / Heart Defects,Congenital / Myocardial Reperfusion Injury	1
1, 2	Completed	Treatment	Angina Pectoris	1
1, 2	Unknown Status	Not Available	Liver Tumors	1
2	Active Not Recruiting	Treatment	Cancer, Breast	1
2	Completed	Prevention	ST-elevation Myocardial Infarction (STEMI)	1
2	Completed	Treatment	Healthy Volunteers	1
2	Completed	Treatment	Lethargy	1
2	Completed	Treatment	Nonvalvular Atrial Fibrillation	1
2	Completed	Treatment	Pain	1
2	Completed	Treatment	Perioperative Pain	1
2	Recruiting	Prevention	Pathological Processes / Prophylaxis of cardiomyopathy	1
2	Recruiting	Treatment	Takotsubo Cardiomyopathy / Takotsubo Syndrome	1
2	Unknown Status	Not Available	Ischemic Heart Diseases	1
2	Unknown Status	Treatment	Acute ST Elevation Myocardial Infarction	1
2, 3	Completed	Diagnostic	Coronary Atherosclerosis / Heart Disease, Ischemic	1
2, 3	Completed	Treatment	Myocardial Infarction (MI)	1
3	Completed	Diagnostic	Coronary Artery Disease	5
3	Completed	Prevention	Coronary Angioplasty	1
3	Completed	Treatment	Acute Myocardial Infarction (AMI)	1
3	Terminated	Diagnostic	Coronary Artery Disease	2
3	Terminated	Prevention	Coronary Artery Disease / Coronary Artery Stenosis	1
3	Unknown Status	Treatment	Percutaneous Coronary Intervention (PCI) / Stable Angina (SA)	1
4	Recruiting	Treatment	Resistant Hypertension	1
Not Available	Completed	Not Available	Coronary Artery Disease	1
Not Available	Completed	Not Available	Type 2 Diabetes Mellitus (T2D)	1
Not Available	Completed	Diagnostic	BMI >30 kg/m2 / Decreased Vascular Flow / Endothelial Dysfunction	1
Not Available	Completed	Diagnostic	Coronary Artery Disease	2
Not Available	Completed	Screening	Diabetes Mellitus, Insulin-Dependent / Ischemia-Reperfusion Injury	1
Not Available	Completed	Supportive Care	Neoplasms, Breast / Neoplasms, Lung	1
Not Available	Completed	Treatment	Heart Failure (HF) / Peripheral Chemoreceptor Hypersensitivity	1
Not Available	Completed	Treatment	Microcirculation / Physiology, Ocular	1
Not Available	Recruiting	Not Available	Coronary Artery Disease / Coronary Microvascular Disease	1
Not Available	Recruiting	Health Services Research	MRI Scans	1
Not Available	Suspended	Not Available	Ischaemia	1
Not Available	Suspended	Not Available	Ischemia-Reperfusion Injury	1
Not Available	Unknown Status	Diagnostic	Atherosclerosis / Endothelial Dysfunction / Inflammatory processes / Myocardial Ischemia	1
Not Available	Unknown Status	Treatment	Tachycardia, Supraventricular	1

Pharmacoeconomics

Manufacturers

Astellas pharma us inc
Akorn inc
App pharmaceuticals llc
Baxter healthcare corp
Bedford laboratories div ben venue laboratories inc
Gland pharma ltd
Luitpold pharmaceuticals inc
Strides arcolab ltd
Teva parenteral medicines inc
Wockhardt ltd

Packagers

Dosage forms

Form	Route	Strength
Cream	Topical	.12 mg/30mL
Liquid	Topical	48 mg/120mL
Solution	Intravenous	6 mg/2mL
Liquid	Intravenous	3 mg
Solution	Intravenous	3 mg/mL
Injection	Intravenous	3 mg/mL
Injection, solution	Intravenous	3 mg/mL
Cream	Topical	.04 mg/100mL
Cream	Topical	.4 mg/mL
Cream	Topical	20 mg/50mL
Liquid	Topical	12.8 mg/32g
Liquid	Topical	12 mg/30mL
Liquid	Topical	54 mg/135mL
Liquid	Topical
Liquid	Topical	12 mg/30g
Solution	Topical	2.8 mg/7mL
Gel	Topical
Cream	Topical	.04 g/100mL
Liquid	Topical	.05 g/130mL
Cream	Topical	.01 g/45mL
Cream	Topical	.02 g/50mL
Cream	Topical	.01 g/30mL
Solution	Topical	1.2 mg/3mL
Patch	Topical	.008 g/20g
Liquid	Topical	.6 mg/6mL
Cream	Topical	.04 mL/100mL
Cream	Topical	.004 g/10g
Liquid	Topical	20 mg/50mL
Gel	Topical	.04 g/100mL
Cream	Topical	.04 g/100g
Liquid	Topical	6 mg/15mL
Liquid	Topical	.04 g/100mL
Solution / drops	Topical
Cream	Topical
Liquid	Topical	.04 g/100g
Kit	Topical
Cream	Topical	.0428 g/100g
Kit	Topical
Cream	Topical	.2 g/100g
Liquid	Topical	2 mg/5mL
Patch	Topical	.01 g/25g
Liquid	Topical	25 mg/50mL
Liquid	Topical	.02 g/50mL
Cream	Topical	.0004 mL/mL
Liquid	Topical	.0004 mL/mL
Cream	Topical	.0004 g/g
Emulsion	Topical	.04 g/100mL
Patch	Topical	.5 g/25g
Cream	Topical	6 g/150g
Cream	Topical	.004 mg/10g
Cream	Topical	.08 mg/20mL
Patch	Topical	.6 mg/3g
Cream	Topical	.02 mg/50mL
Liquid	Topical	.05 mg/125mL
Patch	Topical	.014 g/35g
Cream	Topical	.01 g/27g
Liquid	Topical	.04 mg/100mL
Lipstick	Topical	.001 g/3.5g
Liquid	Topical	.00012 mg/.3mL
Cream	Topical	.00012 mg/.3mL
Cream	Topical	.011 mg/27mL
Cream	Topical	.001 mg/2.5mL
Patch	Topical
Solution	Intravenous	3 mg
Cream	Topical	.0004 1/100mL
Oil	Topical
Solution	Topical
Cream	Topical	.01 g/25g
Patch	Topical	1 g/100g
Spray	Topical
Cream	Topical	.018 g/45mL
Cream	Topical	.012 g/30mL
Cream	Topical	.4 mg/g
Cream	Topical	.04 mL/mL
Patch	Topical	.01 g/25mL
Liquid	Topical	.001 g/3mL
Patch	Topical	.009 g/24mL
Patch	Topical	.008 g/20mL
Liquid	Topical	.001 g/4mL
Lotion	Topical	1 mg/150mL
Liquid	Topical	.04 mL/100mL
Cream	Topical	.02 g/50g
Cream	Topical	.024 g/60g
Powder	Topical
Emulsion	Topical
Emulsion	Topical	.06 g/150mL
Liquid	Topical	.06 g/150mL

Prices

Unit description	Cost	Unit
Adenosine-5 monophosphate	19.74USD	g
Adenosine powder	15.86USD	g
Adenoscan 3 mg/ml vial	10.09USD	ml
Adenosine 12 mg/4 ml vial	8.44USD	ml
Adenosine 6 mg/2 ml vial	8.1USD	ml

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US5731296	No	1995-03-24	2015-03-24	US

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	235.5 °C	PhysProp
water solubility	8230 mg/L	Not Available
logP	-1.05	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
Water Solubility	14.0 mg/mL	ALOGPS
logP	-1.2	ALOGPS
logP	-2.1	ChemAxon
logS	-1.3	ALOGPS
pKa (Strongest Acidic)	12.45	ChemAxon
pKa (Strongest Basic)	4.99	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	139.54 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	63.2 m³·mol^-1	ChemAxon
Polarizability	25.27 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	+	0.9227
Blood Brain Barrier	+	0.9383
Caco-2 permeable	-	0.8957
P-glycoprotein substrate	Non-substrate	0.7026
P-glycoprotein inhibitor I	Non-inhibitor	0.966
P-glycoprotein inhibitor II	Non-inhibitor	0.9533
Renal organic cation transporter	Non-inhibitor	0.9444
CYP450 2C9 substrate	Non-substrate	0.8639
CYP450 2D6 substrate	Non-substrate	0.8349
CYP450 3A4 substrate	Non-substrate	0.5866
CYP450 1A2 substrate	Non-inhibitor	0.9667
CYP450 2C9 inhibitor	Non-inhibitor	0.9595
CYP450 2D6 inhibitor	Non-inhibitor	0.977
CYP450 2C19 inhibitor	Non-inhibitor	0.9514
CYP450 3A4 inhibitor	Non-inhibitor	0.962
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.9701
Ames test	Non AMES toxic	0.9133
Carcinogenicity	Non-carcinogens	0.9182
Biodegradation	Not ready biodegradable	0.9738
Rat acute toxicity	1.9715 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.989
hERG inhibition (predictor II)	Non-inhibitor	0.9102

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)

Download (9.12 KB)

Spectra

Spectrum Type	Description	Splash Key
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (4 TMS)	splash10-0f7w-1890000000-5c70a5423faa5e8eceaf	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (4 TMS)	splash10-001v-0691000000-8f88854b7d5adec5c558	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)	splash10-001s-0790000000-cc3bcd977e11efd4ea25	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (4 TMS)	splash10-00di-9460000000-3ae19bfaa5d2df72f9b1	View in MoNA
GC-MS	GC-MS Spectrum - GC-MS (3 TMS)	splash10-0gc0-0590000000-05874cecded3009c1f4d	View in MoNA
GC-MS	GC-MS Spectrum - GC-MS (4 TMS)	splash10-0fsv-1792000000-b37fd6826f28aaf9e825	View in MoNA
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS	Not Available
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-014r-0890000000-588861a9494ab4680698	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-000i-1900000000-dd7cbed8e76c6e783831	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-000i-2900000000-c6644520b5943b59403d	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-0090000000-3d4fd8ea211eaed10531	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-0900000000-cb58ec56a5faa09c9a02	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-0900000000-9559aa07ec13a688fb16	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-0900000000-f7c1371d8e1058df3a32	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-001i-0940000000-da71247788bf1ba222e2	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-001i-0920000000-f2e8ec028abdd674b5e3	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-001i-0910000000-815ed65588c07415cd65	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-001i-1910000000-2780e737da8848411c4f	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-053r-1900000000-c6c1128990661334c15b	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-014i-0090000000-106e7131507fadd4befb	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-000i-0910000000-1c53823486cd2c23f90e	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-000i-0900000000-f0313435db4847490fd6	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-000i-1900000000-dcd4c2972882dcd7535a	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-000i-2900000000-5ee474864189cef6df64	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positive	splash10-000i-0900000000-17edf36faf6eb5750912	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positive	splash10-000i-0900000000-0591143763a0bad31c23	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-014i-0290000000-f1d71a97ce39145c8e31	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Positive	splash10-00kr-0950000000-9bbdbb14aed287ad5ac8	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-001i-0910000000-35f90965f1f3c2b3236b	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-000i-0900000000-f360cca994696d7ae735	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available
1D NMR	1H NMR Spectrum	Not Available
1D NMR	13C NMR Spectrum	Not Available
2D NMR	[1H,1H] 2D NMR Spectrum	Not Available
2D NMR	[1H,13C] 2D NMR Spectrum	Not Available

Taxonomy

Description

This compound belongs to the class of organic compounds known as purine nucleosides. These are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Purine nucleosides

Sub Class

Not Available

Direct Parent

Purine nucleosides

Alternative Parents

Substituents

Purine nucleoside
Glycosyl compound
N-glycosyl compound
6-aminopurine
Pentose monosaccharide
Imidazopyrimidine
Purine
Aminopyrimidine
Monosaccharide
N-substituted imidazole
Pyrimidine
Imidolactam
Tetrahydrofuran
Azole
Imidazole
Heteroaromatic compound
Secondary alcohol
Organoheterocyclic compound
Azacycle
Oxacycle
Organic oxygen compound
Organic nitrogen compound
Alcohol
Organonitrogen compound
Hydrocarbon derivative
Organopnictogen compound
Organooxygen compound
Amine
Primary alcohol
Primary amine
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

adenosines (CHEBI:16335 )
Ribonucleosides (C00212 )

Targets

Details

1. Adenosine receptor A2a

Kind: Protein
Organism: Human
Pharmacological action: yes
Actions: agonist

General Function:: Identical protein binding
Specific Function:: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Gene Name:: ADORA2A
Uniprot ID:: P29274
Molecular Weight:: 44706.925 Da

References

Trincavelli ML, Daniele S, Martini C: Adenosine receptors: what we know and what we are learning. Curr Top Med Chem. 2010;10(9):860-77. [PubMed:20370662 ]
Schenone S, Brullo C, Musumeci F, Bruno O, Botta M: A1 receptors ligands: past, present and future trends. Curr Top Med Chem. 2010;10(9):878-901. [PubMed:20370661 ]
Ezeamuzie CI, Khan I: The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages. Int Immunopharmacol. 2007 Apr;7(4):483-90. Epub 2006 Dec 29. [PubMed:17321471 ]
Kreckler LM, Wan TC, Ge ZD, Auchampach JA: Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor. J Pharmacol Exp Ther. 2006 Apr;317(1):172-80. Epub 2005 Dec 9. [PubMed:16339914 ]
Kreckler LM, Gizewski E, Wan TC, Auchampach JA: Adenosine suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production by murine macrophages through a protein kinase A- and exchange protein activated by cAMP-independent signaling pathway. J Pharmacol Exp Ther. 2009 Dec;331(3):1051-61. doi: 10.1124/jpet.109.157651. Epub 2009 Sep 11. [PubMed:19749080 ]
Buenestado A, Grassin Delyle S, Arnould I, Besnard F, Naline E, Blouquit-Laye S, Chapelier A, Bellamy JF, Devillier P: The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages. Br J Pharmacol. 2010 Mar;159(6):1304-11. doi: 10.1111/j.1476-5381.2009.00614.x. Epub 2010 Feb 5. [PubMed:20136829 ]
Funakoshi H, Zacharia LC, Tang Z, Zhang J, Lee LL, Good JC, Herrmann DE, Higuchi Y, Koch WJ, Jackson EK, Chan TO, Feldman AM: A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction. Circulation. 2007 May 1;115(17):2307-15. Epub 2007 Apr 16. [PubMed:17438146 ]
Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen JF, Bach FH, Otterbein LE: Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages. J Immunol. 2007 May 1;178(9):5921-9. [PubMed:17442976 ]

Details

2. Adenosine receptor A2b

Kind: Protein
Organism: Human
Pharmacological action: yes
Actions: agonist

General Function:: G-protein coupled adenosine receptor activity
Specific Function:: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Gene Name:: ADORA2B
Uniprot ID:: P29275
Molecular Weight:: 36332.655 Da

References

Trincavelli ML, Daniele S, Martini C: Adenosine receptors: what we know and what we are learning. Curr Top Med Chem. 2010;10(9):860-77. [PubMed:20370662 ]
Schenone S, Brullo C, Musumeci F, Bruno O, Botta M: A1 receptors ligands: past, present and future trends. Curr Top Med Chem. 2010;10(9):878-901. [PubMed:20370661 ]
Ezeamuzie CI, Khan I: The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages. Int Immunopharmacol. 2007 Apr;7(4):483-90. Epub 2006 Dec 29. [PubMed:17321471 ]
Kreckler LM, Wan TC, Ge ZD, Auchampach JA: Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor. J Pharmacol Exp Ther. 2006 Apr;317(1):172-80. Epub 2005 Dec 9. [PubMed:16339914 ]
Buenestado A, Grassin Delyle S, Arnould I, Besnard F, Naline E, Blouquit-Laye S, Chapelier A, Bellamy JF, Devillier P: The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages. Br J Pharmacol. 2010 Mar;159(6):1304-11. doi: 10.1111/j.1476-5381.2009.00614.x. Epub 2010 Feb 5. [PubMed:20136829 ]
Funakoshi H, Zacharia LC, Tang Z, Zhang J, Lee LL, Good JC, Herrmann DE, Higuchi Y, Koch WJ, Jackson EK, Chan TO, Feldman AM: A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction. Circulation. 2007 May 1;115(17):2307-15. Epub 2007 Apr 16. [PubMed:17438146 ]
Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen JF, Bach FH, Otterbein LE: Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages. J Immunol. 2007 May 1;178(9):5921-9. [PubMed:17442976 ]

Details

3. Adenosine receptor A3

Kind: Protein
Organism: Human
Pharmacological action: yes
Actions: agonist

General Function:: G-protein coupled adenosine receptor activity
Specific Function:: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.
Gene Name:: ADORA3
Uniprot ID:: P0DMS8
Molecular Weight:: 36184.175 Da

References

Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Trincavelli ML, Daniele S, Martini C: Adenosine receptors: what we know and what we are learning. Curr Top Med Chem. 2010;10(9):860-77. [PubMed:20370662 ]
Schenone S, Brullo C, Musumeci F, Bruno O, Botta M: A1 receptors ligands: past, present and future trends. Curr Top Med Chem. 2010;10(9):878-901. [PubMed:20370661 ]
Ezeamuzie CI, Khan I: The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages. Int Immunopharmacol. 2007 Apr;7(4):483-90. Epub 2006 Dec 29. [PubMed:17321471 ]
Kreckler LM, Wan TC, Ge ZD, Auchampach JA: Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor. J Pharmacol Exp Ther. 2006 Apr;317(1):172-80. Epub 2005 Dec 9. [PubMed:16339914 ]
Buenestado A, Grassin Delyle S, Arnould I, Besnard F, Naline E, Blouquit-Laye S, Chapelier A, Bellamy JF, Devillier P: The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages. Br J Pharmacol. 2010 Mar;159(6):1304-11. doi: 10.1111/j.1476-5381.2009.00614.x. Epub 2010 Feb 5. [PubMed:20136829 ]
Funakoshi H, Zacharia LC, Tang Z, Zhang J, Lee LL, Good JC, Herrmann DE, Higuchi Y, Koch WJ, Jackson EK, Chan TO, Feldman AM: A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction. Circulation. 2007 May 1;115(17):2307-15. Epub 2007 Apr 16. [PubMed:17438146 ]
Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen JF, Bach FH, Otterbein LE: Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages. J Immunol. 2007 May 1;178(9):5921-9. [PubMed:17442976 ]

Details

4. Adenosine receptor A1

Kind: Protein
Organism: Human
Pharmacological action: yes
Actions: agonist

General Function:: Purine nucleoside binding
Specific Function:: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Gene Name:: ADORA1
Uniprot ID:: P30542
Molecular Weight:: 36511.325 Da

References

Trincavelli ML, Daniele S, Martini C: Adenosine receptors: what we know and what we are learning. Curr Top Med Chem. 2010;10(9):860-77. [PubMed:20370662 ]
Schenone S, Brullo C, Musumeci F, Bruno O, Botta M: A1 receptors ligands: past, present and future trends. Curr Top Med Chem. 2010;10(9):878-901. [PubMed:20370661 ]
Ezeamuzie CI, Khan I: The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages. Int Immunopharmacol. 2007 Apr;7(4):483-90. Epub 2006 Dec 29. [PubMed:17321471 ]
Buenestado A, Grassin Delyle S, Arnould I, Besnard F, Naline E, Blouquit-Laye S, Chapelier A, Bellamy JF, Devillier P: The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages. Br J Pharmacol. 2010 Mar;159(6):1304-11. doi: 10.1111/j.1476-5381.2009.00614.x. Epub 2010 Feb 5. [PubMed:20136829 ]
Funakoshi H, Zacharia LC, Tang Z, Zhang J, Lee LL, Good JC, Herrmann DE, Higuchi Y, Koch WJ, Jackson EK, Chan TO, Feldman AM: A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction. Circulation. 2007 May 1;115(17):2307-15. Epub 2007 Apr 16. [PubMed:17438146 ]
Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen JF, Bach FH, Otterbein LE: Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages. J Immunol. 2007 May 1;178(9):5921-9. [PubMed:17442976 ]

Enzymes

Details

1. Adenosine deaminase

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Zinc ion binding
Specific Function:: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.
Gene Name:: ADA
Uniprot ID:: P00813
Molecular Weight:: 40764.13 Da

References

Kopff M, Kopff A, Puczkowski S: [Adenosine deaminase: isoenzymes ADA1 and ADA2]. Pol Merkur Lekarski. 1997 Dec;3(18):288-90. [PubMed:9523470 ]

Details

2. Adenosine kinase

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Poly(a) rna binding
Specific Function:: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Gene Name:: ADK
Uniprot ID:: P55263
Molecular Weight:: 40545.075 Da

References

Boison D: Adenosine kinase, epilepsy and stroke: mechanisms and therapies. Trends Pharmacol Sci. 2006 Dec;27(12):652-8. Epub 2006 Oct 23. [PubMed:17056128 ]

Transporters

Details

1. Solute carrier family 28 member 3

Kind: Protein
Organism: Human
Pharmacological action: unknown

General Function:: Pyrimidine- and adenine-specific:sodium symporter activity
Specific Function:: Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazaurid...
Gene Name:: SLC28A3
Uniprot ID:: Q9HAS3
Molecular Weight:: 76929.61 Da

References

Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM: Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). Pharmacogenomics J. 2005;5(3):157-65. [PubMed:15738947 ]

Drug created on June 13, 2005 07:24 / Updated on May 19, 2017 16:35

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Structure for DB00640 (Adenosine)

Targets

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Enzymes

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Transporters

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