Adenosine - DrugBank

ID Pharmacology Interactions References Trials Economics Properties Spectra Taxonomy

Targets (4)Enzymes (2)Transporters (1)

Targets (4)Enzymes (2)Transporters (1)Biointeractions (6)

Identification

Name

Adenosine

Accession Number

DB00640 (APRD00132)

Type

Small Molecule

Groups

Approved, Investigational

Description

A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. [PubChem]

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

6-Amino-9-beta-D-ribofuranosyl-9H-purine

9-beta-D-Ribofuranosidoadenine

9-beta-D-Ribofuranosyl-9H-purin-6-amine

Ade-rib

Adenin riboside

Adenine deoxyribonucleoside

Adenocor

Adenosin

Adenosina

Adénosine

Adenosinum

Adenyldeoxyriboside

Ado

beta-D-Adenosine

Deoxyadenosine

Desoxyadenosine

External IDs

SR 96225 / SR-96225 / USAF CB-10

Product Ingredients

Not Available

Approved Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Adenocard	Solution	3 mg/mL	Intravenous	Astellas Pharma Inc	1989-10-30	Not applicable	US
Adenocard	Solution	6 mg/2mL	Intravenous	Cardinal Health	1989-10-30	Not applicable	US
Adenocard	Solution	3 mg/mL	Intravenous	Remedy Repack	2015-08-18	2017-09-05	US
Adenocard	Solution	3 mg/mL	Intravenous	Cardinal Health	1989-10-30	Not applicable	US
Adenocard - Liq Rapid Bolus IV 3mg/ml	Solution	3 mg	Intravenous	Astellas Pharma Inc	1996-08-14	2014-12-05	Canada
Adenocard Injection -pre-filled Syringe	Solution	3 mg	Intravenous	Astellas Pharma Inc	1994-12-31	Not applicable	Canada
Adenocard Liq IV 3mg/ml	Liquid	3 mg	Intravenous	Fujisawa Pharmaceutical Co, Division Of Fujisawa Canada Inc.	1993-12-31	1996-09-09	Canada
Adenocard Liq IV 3mg/ml (pre-filled Syringe)	Liquid	3 mg	Intravenous	Fujisawa Pharmaceutical Co, Division Of Fujisawa Canada Inc.	1994-12-31	1996-09-09	Canada
Adenoscan	Solution	3 mg/mL	Intravenous	Astellas Pharma Inc	1995-05-18	Not applicable	US
Adenoscan	Solution	3 mg/mL	Intravenous	Remedy Repack	2013-06-10	2016-10-13	US
Adenoscan	Solution	3 mg/mL	Intravenous	Remedy Repack	2013-06-27	2017-04-14	US
Adenoscan - (for IV Infusion Only)	Solution	3 mg	Intravenous	Astellas Pharma Inc	1995-12-31	2009-05-29	Canada
Adenosine Injection	Solution	3 mg	Intravenous	Fresenius Kabi	Not applicable	Not applicable	Canada
Adenosine Injection	Solution	3 mg	Intravenous	Fresenius Kabi	Not applicable	Not applicable	Canada
Adenosine Injection	Solution	3 mg	Intravenous	Fresenius Kabi	2007-03-27	Not applicable	Canada
Adenosine Injection, USP	Solution	3 mg	Intravenous	Mylan Pharmaceuticals	Not applicable	Not applicable	Canada
Adenosine Injection, USP	Solution	3 mg	Intravenous	Mylan Pharmaceuticals	Not applicable	Not applicable	Canada
Aj-adenosine	Solution	3 mg	Intravenous	Agila Jamp Canada Inc	Not applicable	Not applicable	Canada
Aj-adenosine	Solution	3 mg	Intravenous	Agila Jamp Canada Inc	Not applicable	Not applicable	Canada
PMS-adenosine	Solution	3 mg	Intravenous	Pharmascience Inc	2001-06-07	Not applicable	Canada

Approved Generic Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Adenosine	Injection, solution	3 mg/mL	Intravenous	Remedy Repack	2014-05-23	2016-12-16	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	General Injectables & Vaccines	2011-10-05	Not applicable	US
Adenosine	Injection	3 mg/mL	Intravenous	West Ward Pharmaceutical	2004-06-16	Not applicable	US
Adenosine	Injection	3 mg/mL	Intravenous	Wockhardt	2009-07-20	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Akorn	2014-10-02	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	AGILA SPECIALTIES PRIVATE LIMITED	2014-03-22	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Cardinal Health	2011-03-17	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Mylan Institutional	2014-03-28	Not applicable	US
Adenosine	Injection	3 mg/mL	Intravenous	Sagent Pharmaceuticals	2009-09-01	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Teva Parenteral Medicines, Inc.	2013-09-23	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Fresenius Kabi	2005-11-23	Not applicable	US
Adenosine	Injection	3 mg/mL	Intravenous	General Injectables & Vaccines	2014-03-26	2017-02-09	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Hospira, Inc.	2014-03-24	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Baxter Laboratories	2010-04-20	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Heritage	2014-08-01	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Sagent Pharmaceuticals	2014-03-28	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Teva Parenteral Medicines, Inc.	2013-09-23	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Remedy Repack	2013-07-16	2016-12-31	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Akorn	2011-03-15	Not applicable	US
Adenosine	Injection	3 mg/mL	Intravenous	Wockhardt	2009-07-20	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Physicians Total Care, Inc.	2006-03-16	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Mylan Institutional	2014-03-28	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Heritage	2014-08-01	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Remedy Repack	2016-06-07	2017-02-15	US

Approved Over the Counter Products

Not Available

Unapproved/Other Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
A.H.C Real Eye For Face	Cream	.12 mg/30mL	Topical	Carver Korea Co.,Ltd.	2013-06-21	Not applicable	US
A.H.C. Collagen Cream	Cream	20 mg/50mL	Topical	Carver Korea Co.,Ltd.	2013-08-15	Not applicable	US
A.H.C. Collagen Toner	Liquid	48 mg/120mL	Topical	Carver Korea Co.,Ltd.	2013-08-15	Not applicable	US
Adenosine	Injection, solution	3 mg/mL	Intravenous	Cantrell Drug Company	2015-02-05	Not applicable	US
Advanced Snail 92 All in One Cream	Cream	.04 mg/100mL	Topical	Cosrx Inc.	2016-05-24	2017-06-29	US
AHC Collagen Serum	Liquid	12 mg/30mL	Topical	Carver Korea Co.,Ltd.	2013-08-15	Not applicable	US
AHC Complex Choice EGF Booster	Cream	.4 mg/mL	Topical	Carver Korea Co.,Ltd.	2013-08-15	Not applicable	US
AHC Complex Choice EGF Booster	Cream	.4 mg/mL	Topical	Carver Korea Co.,Ltd.	2013-08-15	Not applicable	US
AHC Hydration Special Gen Cream	Cream	20 mg/50mL	Topical	Carver Korea Co.,Ltd.	2013-07-15	Not applicable	US
AHC Hydration Special Gen Mask	Liquid	12.8 mg/32g	Topical	Carver Korea Co.,Ltd.	2013-07-15	Not applicable	US
AHC Hydration Special Gen Serum	Liquid	12 mg/30mL	Topical	Carver Korea Co.,Ltd.	2013-07-15	Not applicable	US
AHC Hydration Special Gen Solution	Liquid	54 mg/135mL	Topical	Carver Korea Co.,Ltd.	2013-07-15	Not applicable	US
AHC Phyto Complex Mask	Liquid	12 mg/30g	Topical	Carver Korea Co.,Ltd.	2016-10-20	Not applicable	US
AHC Vital C Complex Mask	Liquid	12 mg/30g	Topical	Carver Korea Co.,Ltd.	2013-08-15	Not applicable	US
All Nations A D C Special Program	Solution	.002 g/6mL	Topical	An Co Ltd.	2017-06-01	Not applicable	US
An Adc Sp F	Solution	2.8 mg/7mL	Topical	An Co Ltd.	2016-05-01	Not applicable	US
Anti aging	Cream	.012 g/30mL	Topical	Get Beauty	2017-06-01	Not applicable	US
Anti aging ample	Liquid	.012 g/30mL	Topical	Get Beauty	2017-06-01	Not applicable	US
Antibe Super Hydrating Moisturizing Cream	Cream	.04 g/100mL	Topical	Modongee Co., Ltd.	2015-07-01	Not applicable	US
Applicell Essential Toner	Liquid	.05 g/130mL	Topical	Anc Hn B Inc.	2016-10-10	Not applicable	US
Applicell Intensive Serum	Cream	.01 g/45mL	Topical	Anc Hn B Inc.	2016-10-10	Not applicable	US
Applicell Miracle	Cream	.02 g/50mL	Topical	Anc Hn B Inc.	2016-10-10	Not applicable	US
Applicell Perfect Eye	Cream	.01 g/30mL	Topical	Anc Hn B Inc.	2016-10-10	Not applicable	US
Applicell Timeless Ampoule	Solution	1.2 mg/3mL	Topical	Anc Hn B Inc.	2016-10-10	Not applicable	US
Aqua Collagen Coenzyme Q10 Hydro Mask	Patch	.008 g/20g	Topical	Nature Republic Co., Ltd.	2015-02-01	Not applicable	US
Aqua Collagen Solu tion Coenzyme Q10 Hydroge l Mask	Patch	.008 g/20g	Topical	Nature Republic Co., Ltd.	2015-02-01	Not applicable	US
Are You The Real Branch Mask	Patch	.01 g/25g	Topical	Cj Olivenetworks Co., Ltd	2017-07-01	Not applicable	US
Are You The Real Cat Mask	Patch	.01 g/25g	Topical	Cj Olivenetworks Co., Ltd	2017-07-01	Not applicable	US
Are You The Real Shrek Mask	Patch	.01 g/25g	Topical	Cj Olivenetworks Co., Ltd	2017-07-01	Not applicable	US
B.S.c Ampul	Liquid	.6 mg/6mL	Topical	Cellcos Inc	2013-01-30	Not applicable	US
Bellaskin Skin-rebirth Contour	Cream	.04 mL/100mL	Topical	Ajou Medics Co., Ltd	2011-09-13	Not applicable	US
BENTON FERMENTATION EYE 10g	Cream	.004 g/10g	Topical	Benton Korea	2016-08-01	Not applicable	US
Biotoc Regen Ampoule	Liquid	.04 g/100mL	Topical	Dermafirm Inc.	2017-09-04	Not applicable	US
Biotoc Regen Peel	Gel	.04 g/100g	Topical	Dermafirm Inc.	2017-09-04	Not applicable	US
Biotoc Regen Serum	Gel	.04 g/100g	Topical	Dermafirm Inc.	2017-09-04	Not applicable	US
BOTANIC HEAL boH Air Jet Daily Mask Collagen	Patch	.01 g/25mL	Topical	Cj Olivenetworks Co., Ltd	2017-07-01	Not applicable	US
BOTANIC HEAL boH Derma Water Ceramide	Emulsion	.06 g/150mL	Topical	Cj Olivenetworks Co., Ltd	2017-07-01	Not applicable	US
BOTANIC HEAL boH Derma Water Ceramide Ge l	Cream	.03 g/95g	Topical	Cj Olivenetworks Co., Ltd	2017-07-01	Not applicable	US
BOTANIC HEAL boH Derma Water Ceramide Toner	Liquid	.06 g/150mL	Topical	Cj Olivenetworks Co., Ltd	2017-07-01	Not applicable	US
Brucke Keep Cooling Foilgel Lifting Mask	Liquid	.04 g/100g	Topical	Nature4 Co., Ltd.	2017-04-12	Not applicable	US
Capture Hyaluronic Ampoule	Liquid	20 mg/50mL	Topical	Carver Korea Co.,Ltd.	2013-07-05	Not applicable	US
Caviall Perfect Repair Serum	Gel	.04 g/100mL	Topical	C&bcosmetic Co.,ltd.	2017-03-10	Not applicable	US
Caviallcrystal	Cream	.04 g/100g	Topical	C&bcosmetic Co.,ltd.	2017-02-16	Not applicable	US
COMPLETE CHOICE Moisture Amploule	Liquid	6 mg/15mL	Topical	Carver Korea Co.,Ltd.	2013-07-05	Not applicable	US
Dcs Merderm Jeju Lava Seawater	Cream	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2016-12-01	Not applicable	US
Dcs Merderm Jeju Lava Seawater Ampoule	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2016-12-01	Not applicable	US
Dcs Merderm Jeju Lava Seawater Eye	Cream	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-01-06	Not applicable	US
Dcs Merderm Jeju Lava Seawater Toner	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2016-12-01	Not applicable	US
DCS Super Aqua Mask	Emulsion	.04 g/100g	Topical	Ami Cosmetic Co.,Ltd.	2017-03-16	Not applicable	US
DCS Ultra Nutrition Mask	Liquid	.04 g/100g	Topical	Ami Cosmetic Co.,Ltd.	2017-03-16	Not applicable	US
Deepair Micro Intensive Magic	Cream	.04 g/100mL	Topical	Acosmetic. co.ltd	2016-08-01	Not applicable	US
Dpc Collagen Booster Mask	Liquid	.04 g/100g	Topical	Msco	2017-08-23	Not applicable	US
Dr. Althea Pore-Control Charcoal Mask	Liquid	.04 g/100g	Topical	Dr. Althea	2016-12-01	Not applicable	US
Dr. Althea Water Glow Aqua Ampoule Mask	Liquid	.04 g/100g	Topical	Dr. Althea	2016-12-01	Not applicable	US
Dr. Gloderm Tabrx Wrinkletox	Cream	.0428 g/100g	Topical	Dr.gloderm	2017-03-01	Not applicable	US
Dr. Gloderm Tabrx Wrinkletox Mask	Kit		Topical	Dr.gloderm	2017-03-23	Not applicable	US
Dr. Gloderm Time To Wrinkletox Mask	Liquid	.04 g/100mL	Topical	Dr.gloderm	2017-03-01	Not applicable	US
Dr.eslee Triple Action BB	Cream	.2 g/100g	Topical	Ajou Medics Co., Ltd	2011-09-13	Not applicable	US
Drh T Stem Cell	Liquid	2 mg/5mL	Topical	New & New Co.,ltd.	2016-10-01	Not applicable	US
Drh T Stem Cell	Cream	.02 g/50g	Topical	New & New Co.,ltd.	2016-10-01	Not applicable	US
Edge Cutimal Tiger Anti-Wrinkle Mask	Patch	.01 g/25g	Topical	Oneskin Cosmetics Co., Ltd.	2016-11-01	Not applicable	US
ELCURE AOUT Rose	Liquid	.04 mL/100mL	Topical	Elcure Co., Ltd.	2011-08-22	2017-05-24	US
Elcure Q Serum	Liquid	25 mg/50mL	Topical	Elcure Co., Ltd.	2013-07-18	2017-04-21	US
Herb Blending	Cream	.012 g/30mL	Topical	Nature Republic Co., Ltd.	2017-04-01	Not applicable	US
Herb Blending	Emulsion	.06 g/150mL	Topical	Nature Republic Co., Ltd.	2017-04-01	Not applicable	US
Herb Blending Essence	Liquid	.02 g/50mL	Topical	Nature Republic Co., Ltd.	2017-04-01	Not applicable	US
Herb Blending Toner	Liquid	.06 g/150mL	Topical	Nature Republic Co., Ltd.	2017-04-01	Not applicable	US
IASO A5 Super Brightening Formula	Cream	.0004 mL/mL	Topical	Iaso Inc	2010-12-21	Not applicable	US
IASO Pregressive Age Care Eye	Cream	.0004 g/g	Topical	Iaso Inc	2011-01-09	Not applicable	US
IASO progressive age care	Cream	.0004 g/g	Topical	Iaso Inc	2011-01-09	Not applicable	US
IASO progressive age care emulsion	Cream	.0004 mL/mL	Topical	Iaso Inc	2011-01-01	Not applicable	US
IASO progressive age care serum	Cream	.0004 mL/mL	Topical	Iaso Inc	2011-01-09	Not applicable	US
IASO progressive age care toner	Liquid	.0004 mL/mL	Topical	Iaso Inc	2011-01-01	Not applicable	US
IASO Triple Protection BB SPF 30 PA	Cream	.0004 g/g	Topical	Iaso Inc	2011-01-09	Not applicable	US
JEJUEN Aloe Soothing Extreme Micro Silky Mask	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-21	Not applicable	US
Jejuen Black Bean Ferment	Emulsion	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-16	Not applicable	US
Jejuen Black Bean Ferment	Cream	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-16	Not applicable	US
Jejuen Black Bean Ferment Toner	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-16	Not applicable	US
JEJUEN Camellia Wrinkle Care Extreme Micro Silky Mask	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-21	Not applicable	US
JEJUEN Hyaluron Waterful Extreme Micro Silky Mask	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-01	Not applicable	US
JEJUEN Rape Flower Shining Extreme Micro Silky Mask	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-01	Not applicable	US
JEJUEN Volcanic Pore Zero Extreme Micro Silky Mask	Liquid	.04 g/100mL	Topical	Ami Cosmetic Co.,Ltd.	2017-03-01	Not applicable	US
Jeunesseng Eye Bag Removal	Cream	.04 g/100mL	Topical	Frontier Edu	2017-08-29	Not applicable	US
Limulus Nourishing	Cream	.04 g/100mL	Topical	Skin R&d	2017-05-01	Not applicable	US
Lovely Geranium Aromatherapy Mask	Patch	.01 g/25g	Topical	Aroma Yong	2017-05-01	Not applicable	US
Lovely Geranium Aromatherapy Mask	Patch	.5 g/25g	Topical	Aroma Yong	2017-04-01	2017-05-24	US
Mamachi Moms Stretch Mark Cream	Cream	6 g/150g	Topical	Supio Co,. Ltd.	2014-05-01	Not applicable	US
Manefit Beauty Planner Blackberry Firming Eye Mask	Cream	.004 mg/10g	Topical	Imine Co., Ltd.	2016-03-04	Not applicable	US
Manefit Beauty Planner Lavender Wrinkle Lifting Mask	Cream	.08 mg/20mL	Topical	Imine Co., Ltd.	2014-07-17	Not applicable	US
Mefactory 3Step Piggy Nose Pore Strip Step 01 Pore Opening Sheet	Patch	.6 mg/3g	Topical	Me Factory Co., Ltd.	2017-02-01	Not applicable	US
MIOGGI Healing Effector RX Collagenic	Cream	.02 mg/50mL	Topical	Colorpink R&D Inc.	2012-08-20	Not applicable	US
MIOGGI Magic Advanced Skin Essential Activator	Liquid	.05 mg/125mL	Topical	Colorpink R&D Inc.	2012-08-20	Not applicable	US
misoli Power Snail and Collagen Hydrog el Mask Pack	Patch	.014 g/35g	Topical	Jt Co., Ltd.	2016-10-10	Not applicable	US
Niveola 3d Animal Cat Mask Pack	Cream	.01 g/27g	Topical	Unisource International Co., Ltd.	2015-10-08	Not applicable	US
Niveola 3d Animal Dog Mask Pack	Cream	.01 g/27g	Topical	Unisource International Co., Ltd.	2015-10-08	Not applicable	US
NMC Magic Serum	Liquid	.04 mg/100mL	Topical	Nmc (Natural Magma Cosmetics)	2013-07-11	Not applicable	US
NMC Staypot double programing cream	Liquid	.04 mg/100mL	Topical	Nmc (Natural Magma Cosmetics)	2013-07-11	Not applicable	US
NoTS Li p Shimmer Gloss	Lipstick	.001 g/3.5g	Topical	No Ts Co.,Ltd	2016-07-01	Not applicable	US
Oozoo Face Ampoule Alpha One Hydro Lift	Liquid	.00012 mg/.3mL	Topical	Outin Futures Corp.	2016-01-21	2016-10-13	US
Oozoo Face Ampoule Alpha One Nutrient	Cream	.00012 mg/.3mL	Topical	Outin Futures Corp.	2016-01-22	2016-10-13	US
Oozoo Face Mask Alpha One Hydro Lift	Cream	.011 mg/27mL	Topical	Outin Futures Corp.	2016-01-20	2016-10-13	US
Oozoo Face Mask Alpha One Illumination Ampoule	Cream	.00012 mg/.3mL	Topical	Outin Futures Corp.	2016-01-31	2016-10-13	US
Oozoo Face Mask Alpha One Illumination Mask	Cream	.011 mg/27mL	Topical	Outin Futures Corp.	2016-01-31	2016-10-13	US
Oozoo Face Mask Alpha One Illumination Serum	Cream	.001 mg/2.5mL	Topical	Outin Futures Corp.	2016-01-31	2016-10-13	US
Oozoo Face Mask Alpha One Nutirient	Cream	.011 mg/27mL	Topical	Outin Futures Corp.	2016-01-22	2016-10-13	US
Oozoo Face Serum Alpha One Hydro Lift	Cream	.001 mg/2.5mL	Topical	Outin Futures Corp.	2016-01-21	2016-10-13	US
Oozoo Face Serum Alpha One Nutrient	Cream	.001 mg/2.5mL	Topical	Outin Futures Corp.	2016-01-22	2016-10-13	US
Orgaplus Rich Yet Light Weight Mask Extra	Patch	.01 g/25g	Topical	Nature & Nature Co., Ltd	2017-06-01	Not applicable	US
Orgaplus Rich Yet Light Weight Serum Extra	Oil	.01 g/30mL	Topical	Nature & Nature Co., Ltd	2017-06-01	Not applicable	US
Perfect V Lifting Premium Mask	Liquid	.04 g/100g	Topical	Avajar Co Ltd	2017-01-01	Not applicable	US
Primerose Snail	Cream	.0004 1/100mL	Topical	Royal Springs Cosmetics Usa, Llc	2015-06-04	Not applicable	US
Purifying Skin Balancing	Cream	.04 g/100mL	Topical	In This Morning	2017-02-08	Not applicable	US
Sallys Box Gold Snail Hydrogel Mask	Cream	.01 g/25g	Topical	Imine Co., Ltd.	2015-01-05	Not applicable	US
Shieldlife Collagen Ion Mask	Patch	1 g/100g	Topical	Orion Electronics Inc.	2016-09-13	Not applicable	US
Skinfood Gold Caviar Collagen Serum	Cream	.018 g/45mL	Topical	Skinfood Co., Ltd.	2011-03-01	Not applicable	US
Skinfood Gold Caviar Serum	Cream	.018 g/45mL	Topical	Skinfood Co., Ltd.	2011-03-01	Not applicable	US
Skinfood Royal Honey Essential Eye	Cream	.012 g/30mL	Topical	Skinfood Co., Ltd.	2016-04-01	Not applicable	US
Skinfood Royal Honey Essential Eye Individual Sample	Cream	.4 mg/g	Topical	Skinfood Co., Ltd.	2016-04-01	Not applicable	US
SOROCI Morning Calming	Cream	.002 g/10g	Topical	Onsaemiro Co., Ltd.	2017-06-01	Not applicable	US
Stem Cell Renew	Cream	.04 mL/mL	Topical	Medon Co., Ltd	2011-04-06	Not applicable	US
Stem Cell Wrinkle Serum	Liquid	.0004 mL/mL	Topical	Medon Co., Ltd	2011-04-06	Not applicable	US
Super Amazing Revolution For MultiLotion	Lotion	.05 g/100mL	Topical	Aimeeskinlab Co., Ltd.	2017-08-01	Not applicable	US
Super Amazing Revolution For Secret	Cream	.05 g/100mL	Topical	Aimeeskinlab Co., Ltd.	2017-08-01	Not applicable	US
The Oozoo Face Gold Foilayer Mask	Patch	.01 g/25mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Face Silver Foilayer Mask	Patch	.01 g/25mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Lightening Cap Sule Activator	Liquid	.001 g/4mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Lightening Mask	Patch	.008 g/20mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Oozoo Bear Aurora Illuminating Ampoule	Liquid	.001 g/3mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Oozoo Bear Aurora Illuminating Mask	Patch	.009 g/24mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Oozoo Bear Black Space Pore Caring Ampoule	Liquid	.001 g/3mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Oozoo Bear Black Space Pore Caring Mask	Patch	.009 g/24mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Oozoo Bear Water Bang Hydrating Ampoule	Liquid	.001 g/3mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Oozoo Bear Water Bang Hydrating Mask	Patch	.008 g/20mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Recovery Cap Sule Activator	Liquid	.001 g/4mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Recovery Mask	Patch	.008 g/20mL	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
Tosowoong Mens Booster Repair	Lotion	1 mg/150mL	Topical	Mantong	2013-07-05	Not applicable	US
U-max Wrinkle Serum	Liquid	.04 mL/100mL	Topical	VS Shinbi Co., Ltd.	2012-06-04	Not applicable	US
Ultimate Moisturizing Honey Overnight Mask	Cream	.02 g/50g	Topical	Cosrx Inc.	2016-05-23	2016-11-08	US
Ultimate Moisturizing Honey Overnight Mask	Cream	.024 g/60g	Topical	Cosrx Inc.	2016-05-23	2017-07-01	US
Yenaan Jinaek	Emulsion	.06 g/150mL	Topical	Yenaan Cosmetics	2017-03-02	Not applicable	US
Yenaan Jinaek Toner	Liquid	.06 g/150mL	Topical	Yenaan Cosmetics	2017-03-02	Not applicable	US

International Brands

Name	Company
Adenocard	Not Available
Adenocor	Sanofi-Aventis
Adenoject	Sun
Adenoscan	Not Available
Adenoz	Celon
Adenozer	Purzer
Adesin	Dae Han New Pharm
Adrekar	Sanofi-Aventis
Atépadène	Mayoly-Spindler
Cardimax	AC Farma
Cardiovert	Sanofi-Aventis
Krenosin	Sanofi-Aventis
Osiden	Square
Pisdeno	Pisa

Brand mixtures

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
A.H.c Cotton 100 Mask Multi Peptide	Adenosine Allantoin Nicotinamide	Patch	Topical	Carver Korea Co.,Ltd.	2017-09-20	Not applicable	US
A.H.c Cotton 100 Mask Skin Ceramide	Adenosine Allantoin Nicotinamide	Patch	Topical	Carver Korea Co.,Ltd.	2017-09-05	Not applicable	US
A.H.c Cotton 100 Mask Soy Isoflavone	Adenosine Allantoin Nicotinamide	Patch	Topical	Carver Korea Co.,Ltd.	2017-09-14	Not applicable	US
A.H.c Cotton 100 Mask Triple Hyaluronic	Adenosine Allantoin Nicotinamide	Patch	Topical	Carver Korea Co.,Ltd.	2017-09-20	Not applicable	US
Abalone Aqua Flood Water	Adenosine Nicotinamide	Cream	Topical	C&bcosmetic Co.,ltd.	2017-02-16	Not applicable	US
ABALONE CrystalDouble EX	Adenosine Nicotinamide	Cream	Topical	C&bcosmetic Co.,ltd.	2017-02-16	Not applicable	US
Abalone Crystaldouble EX Ampoule	Adenosine Arbutin	Liquid	Topical	C&bcosmetic Co.,ltd.	2017-03-10	Not applicable	US
Abalone Crystaldouble EX Bb	Adenosine Nicotinamide Octinoxate Octocrylene Titanium dioxide	Cream	Topical	C&bcosmetic Co.,ltd.	2017-03-10	Not applicable	US
Abalone Crystaldouble EX Cc	Adenosine Nicotinamide Octinoxate Titanium dioxide	Cream	Topical	C&bcosmetic Co.,ltd.	2017-03-10	Not applicable	US
Abalone Crystaldouble EX Homme	Adenosine Nicotinamide	Cream	Topical	C&bcosmetic Co.,ltd.	2017-02-20	Not applicable	US
ABALONE CrystalDouble EX SERUM	Adenosine Nicotinamide	Gel	Topical	C&bcosmetic Co.,ltd.	2017-02-16	Not applicable	US
Absolute Total BB SPF37 PA 3Plus	Adenosine Arbutin Titanium dioxide Zinc oxide	Cream	Topical	Wizcoz Corporation Ltd	2011-12-01	Not applicable	US
AHC Premium Intense Contour Balm	Adenosine Aluminium tristearate Aluminum hydroxide Arbutin Methicone (20 cst) Octinoxate Talc Titanium dioxide Zinc oxide	Cream	Topical	Carver Korea Co.,Ltd.	2014-01-15	Not applicable	US
AHC Revitalizing Special Gen Cream	Adenosine Nicotinamide	Cream	Topical	Carver Korea Co.,Ltd.	2013-07-10	Not applicable	US
AHC Revitalizing Special Gen Mask	Adenosine Nicotinamide	Liquid	Topical	Carver Korea Co.,Ltd.	2013-07-10	Not applicable	US
AHC Revitalizing Special Gen Serum	Adenosine Nicotinamide	Liquid	Topical	Carver Korea Co.,Ltd.	2013-10-05	Not applicable	US
AHC Revitalizing Special Gen Solution	Adenosine Nicotinamide	Liquid	Topical	Carver Korea Co.,Ltd.	2013-07-10	Not applicable	US
AHC Vital Complex C-15 Ampoule	Adenosine Arbutin	Liquid	Topical	Carver Korea Co.,Ltd.	2013-08-15	Not applicable	US
Allvit Revital Up	Adenosine Nicotinamide	Cream	Topical	Coway Co., Ltd.	2016-12-01	Not applicable	US
Antibe Beausenne Special Ampoule	Adenosine Nicotinamide	Gel	Topical	Modongee Co., Ltd.	2015-07-01	Not applicable	US
Aprilskin Magic Snow Fixing Foundation 22 Pink Beige	Adenosine Nicotinamide Titanium dioxide	Liquid	Topical	Aprilskin Co., Ltd.	2017-05-01	Not applicable	US
Aprilskin Magic Snow Fixing Foundation 23 Natural Beige	Adenosine Nicotinamide Titanium dioxide	Liquid	Topical	Aprilskin Co., Ltd.	2017-05-01	Not applicable	US
ATONO2 Oxygen Mothers Cream	Adenosine Nicotinamide	Cream	Topical	Laorganic Co., Ltd.	2014-11-01	Not applicable	US
Birds Nest Forever Young Multi Care Lifting	Adenosine Nicotinamide	Cream	Topical	F&Co Co., Ltd.	2015-03-01	Not applicable	US
BOTANIC HEAL boH 360 Lifting Solu tion	Adenosine Nicotinamide	Patch	Topical	Cj Olivenetworks Co., Ltd	2017-07-01	Not applicable	US
BOTANIC HEAL boH Air Jet Daily Mask Panthenol	Adenosine Nicotinamide	Patch	Topical	Cj Olivenetworks Co., Ltd	2017-07-01	Not applicable	US
BOTANIC HEAL boH Derma Defense All In One Essence	Adenosine Nicotinamide	Cream	Topical	Cj Olivenetworks Co., Ltd	2017-07-01	Not applicable	US
BOTANIC HEAL boH Derma Intensive Energy Essence	Adenosine Nicotinamide	Liquid	Topical	Cj Olivenetworks Co., Ltd	2017-07-01	Not applicable	US
BOTANIC HEAL boH Derma Intensive Panthenol	Adenosine Nicotinamide	Cream	Topical	Cj Olivenetworks Co., Ltd	2017-07-01	Not applicable	US
BOTANIC HEAL boH Gauze Hydra Solu tion	Adenosine Nicotinamide	Patch	Topical	Cj Olivenetworks Co., Ltd	2017-07-01	Not applicable	US
Brucke A.C.C. Cure Ampoule	Adenosine Nicotinamide	Gel	Topical	Nature4 Co., Ltd.	2017-05-15	Not applicable	US
Brucke Keep Cooling Hydrogel Soothing Mask	Adenosine Nicotinamide	Liquid	Topical	Nature4 Co., Ltd.	2017-04-12	Not applicable	US
Camellia Air Cushion 21 SPF50 PA	Adenosine Nicotinamide Titanium dioxide	Cream	Topical	Tov Co., Ltd	2016-11-08	Not applicable	US
Camellia Air Cushion 22 SPF50 PA	Adenosine Nicotinamide Titanium dioxide	Cream	Topical	Tov Co., Ltd	2016-11-08	Not applicable	US
Camellia Calming Sleeping Mask	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-02-23	Not applicable	US
Camellia CC Cream 21 SPF45 PA	Adenosine Nicotinamide Titanium dioxide	Cream	Topical	Tov Co., Ltd	2016-11-08	Not applicable	US
Camellia CC Cream 22 SPF45 PA	Adenosine Nicotinamide Titanium dioxide	Cream	Topical	Tov Co., Ltd	2016-11-08	Not applicable	US
Camellia Cooling CC 21 SPF50 PA	Adenosine Nicotinamide Titanium dioxide	Cream	Topical	Tov Co., Ltd	2016-11-08	Not applicable	US
Camellia Cooling CC 22 SPF50 PA	Adenosine Nicotinamide Titanium dioxide	Cream	Topical	Tov Co., Ltd	2016-11-08	Not applicable	US
Camellia Vital Dual Serum	Adenosine Nicotinamide	Solution	Topical	Tov Co., Ltd	2016-09-27	Not applicable	US
Camellia Wrinkle Free Eye	Adenosine Nicotinamide	Solution	Topical	Tov Co., Ltd	2016-09-28	Not applicable	US
Capture Collagen Ampoule	Adenosine Nicotinamide	Liquid	Topical	Carver Korea Co.,Ltd.	2013-07-05	Not applicable	US
Caviall Real Caviar Multi-perfection O2 Serum	Adenosine Nicotinamide	Gel	Topical	C&bcosmetic Co.,ltd.	2017-02-16	Not applicable	US
Cellbn Damage Anti-aging Eye Reviver	Adenosine Arbutin	Cream	Topical	Worldcostec.co.,ltd	2017-05-26	Not applicable	US
Cellbn Damage Deep Moisture	Adenosine Arbutin	Cream	Topical	Worldcostec.co.,ltd	2017-05-26	Not applicable	US
Cellbn Damage Multi Action Toner	Adenosine Arbutin	Liquid	Topical	Worldcostec.co.,ltd	2017-05-26	Not applicable	US
Cellbn Damage Overnight Recovery	Adenosine Arbutin	Cream	Topical	Worldcostec.co.,ltd	2017-05-26	Not applicable	US
Cellbn Damage Precious Serum	Adenosine Arbutin	Gel	Topical	Worldcostec.co.,ltd	2017-05-26	Not applicable	US
Cellbn Sp High Multi Serum	Adenosine Arbutin	Gel	Topical	Worldcostec.co.,ltd	2017-05-26	Not applicable	US
Cellbn Sp Lifting Concentrateampoul	Adenosine Arbutin	Gel	Topical	Worldcostec.co.,ltd	2017-05-26	2017-06-01	US
Cellbn Sp Lifting Concentrateampoule	Adenosine Arbutin	Gel	Topical	Worldcostec.co.,ltd	2017-05-26	Not applicable	US
CELLSTORY Plus Cell Activator Ampoule	Adenosine Nicotinamide	Liquid	Topical	Beauren Korea Inc.	2017-08-01	Not applicable	US
CELLSTORY Plus Cell Awake Essence	Adenosine Nicotinamide	Liquid	Topical	Beauren Korea Inc.	2017-08-01	Not applicable	US
CELLSTORY Plus Cell Calming Mask	Adenosine Nicotinamide	Patch	Topical	Beauren Korea Inc.	2017-08-01	Not applicable	US
CELLSTORY Plus Cell Fluid	Adenosine Nicotinamide	Liquid	Topical	Beauren Korea Inc.	2017-08-01	Not applicable	US
CELLSTORY Plus Cell Recovery	Adenosine Nicotinamide	Cream	Topical	Beauren Korea Inc.	2017-08-01	Not applicable	US
CELLSTORY Plus Cell Ultra	Adenosine Nicotinamide	Gel	Topical	Beauren Korea Inc.	2017-08-01	Not applicable	US
CELLSTORY Plus Cellplant Meso Care	Adenosine Nicotinamide	Liquid	Topical	Beauren Korea Inc.	2017-08-01	Not applicable	US
Cellxv Real Kelp Facial Mask	Adenosine Arbutin	Liquid	Topical	Worldcostec.co.,ltd	2017-05-26	Not applicable	US
Centella 70	Adenosine Nicotinamide	Cream	Topical	Ami Cosmetic Co.,Ltd.	2016-02-23	Not applicable	US
Centella 80 Eye	Adenosine Nicotinamide	Cream	Topical	Ami Cosmetic Co.,Ltd.	2016-02-23	Not applicable	US
Centella 90 Ampoule	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-02-23	Not applicable	US
Centella and Green Tea Callus Mask	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-08-01	Not applicable	US
Centella Reviving Toner	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-02-23	Not applicable	US
CIZAR First Calming Serum	Adenosine Nicotinamide	Liquid	Topical	Kolon Wellcare Co.,ltd.	2017-06-01	Not applicable	US
Conju Princess BB	Adenosine Arbutin Titanium dioxide	Cream	Topical	Conju Inc	2011-01-24	Not applicable	US
D-one By Tamdoan Bb Light	Adenosine Arbutin Diethylamino hydroxybenzoyl hexyl benzoate Octinoxate Octisalate Octocrylene Titanium dioxide Zinc oxide	Cream	Topical	Dran Co.,ltd	2016-02-23	Not applicable	US
D-one By Tamdoan Bb Medium	Adenosine Arbutin Diethylamino hydroxybenzoyl hexyl benzoate Octinoxate Octisalate Octocrylene Titanium dioxide Zinc oxide	Cream	Topical	Dran Co.,ltd	2016-02-23	Not applicable	US
D-one By Tamdoan Sunscreen 50	Adenosine Arbutin Diethylamino hydroxybenzoyl hexyl benzoate Octinoxate Octisalate Octocrylene Titanium dioxide Zinc oxide	Cream	Topical	Dran Co.,ltd	2016-02-23	Not applicable	US
Derma Blemish Balm blemish balm	Adenosine Arbutin Titanium dioxide	Cream	Topical	Universal Cosmetic Co., Ltd	2010-08-05	Not applicable	US
DoctorsLab Returning Platinum Mask	Adenosine Nicotinamide	Patch	Topical	Nature & Nature Co., Ltd.	2016-12-01	Not applicable	US
DoctorsLab Returning Platinum Neck	Adenosine Nicotinamide	Patch	Topical	Nature & Nature Co., Ltd	2017-05-01	Not applicable	US
DPC Dual Master Vitamin C	Adenosine Nicotinamide	Liquid	Topical	Msco	2017-08-23	Not applicable	US
DPC Noblesse Suta Eye	Adenosine Nicotinamide	Cream	Topical	Msco	2017-07-01	Not applicable	US
DPC Skin Up Perfection	Adenosine Nicotinamide	Cream	Topical	Msco	2017-08-23	Not applicable	US
Dr Deep Aqua Wrinklecream	Adenosine Allantoin	Cream	Topical	Mineral House Corporation	2012-01-01	2017-04-20	US
Dr G deWrinkle BOOSTER ample by EGF	Adenosine Glycerin	Solution / drops	Topical	The Doctor's Cosmetic Inc	2009-11-01	Not applicable	US
Dr G deWrinkle FORTIFIER by EGF	Adenosine Glycerin	Cream	Topical	The Doctor's Cosmetic Inc	2009-11-01	Not applicable	US
Dr G deWrinkle REFORMER by EGF	Adenosine Dimethicone	Cream	Topical	The Doctor's Cosmetic Inc	2009-11-01	Not applicable	US
Dr. Gloderm Tabrx Liftup	Adenosine Nicotinamide	Cream	Topical	Dr.gloderm	2017-03-01	Not applicable	US
Dr. Gloderm Tabrx Liftup Mask	Adenosine Nicotinamide	Kit	Topical	Dr.gloderm	2017-03-27	Not applicable	US
Dr. Gloderm Time To Liftup Mask	Adenosine Nicotinamide	Liquid	Topical	Dr.gloderm	2017-03-01	Not applicable	US
Dr. Pepti CENTELLA TONER	Adenosine Nicotinamide	Liquid	Topical	J&coceu Co Ltd	2016-12-01	Not applicable	US
Dr. Pepti INTENSIVE	Adenosine Nicotinamide	Cream	Topical	J&coceu Co Ltd	2016-12-01	Not applicable	US
Dr.althea Aurora Cover Cushion 21	Adenosine Nicotinamide Octinoxate Octisalate Octocrylene Titanium dioxide Zinc oxide	Liquid	Topical	Dr. Althea	2017-04-03	Not applicable	US
Dr.G Brightening Up Cushion SPF50 Plus PA Plus Plus Plus	Adenosine Nicotinamide Titanium dioxide	Liquid	Topical	GOWOONSESANG COSMETICS CO., LTD.	2016-10-01	Not applicable	US
DRH Whitening G2	Adenosine Arbutin	Cream	Topical	New & New Co.,ltd.	2016-10-01	Not applicable	US
Forestheal Eye	Adenosine Nicotinamide	Gel	Topical	Bonne Co., Ltd.	2017-08-01	Not applicable	US
Forestheal Vitamin C Moisturizer	Adenosine Nicotinamide	Cream	Topical	Bonne Co., Ltd.	2017-08-01	Not applicable	US
Forestheal Vitamin C Serum	Adenosine Nicotinamide	Cream	Topical	Bonne Co., Ltd.	2017-08-01	Not applicable	US
Galactomyces 70	Adenosine Nicotinamide	Cream	Topical	Ami Cosmetic Co.,Ltd.	2016-09-01	Not applicable	US
GALACTOMYCES 80 Contouring EYE	Adenosine Nicotinamide	Cream	Topical	Ami Cosmetic Co.,Ltd.	2016-09-01	Not applicable	US
Galactomyces 90 Ampoule	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-09-01	Not applicable	US
Galactomyces 95 Whitening Power Essence	Adenosine Nicotinamide	Cream	Topical	Cosrx Inc.	2015-12-23	2017-06-29	US
Galactomyces and Rice Callus Mask	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-08-01	Not applicable	US
Galactomyces First Essence	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-09-27	Not applicable	US
Galactomyces Radiance Toner	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-09-01	Not applicable	US
Gd11 Advanced Lab Energy Ampoule	Adenosine Nicotinamide	Liquid	Topical	Coson Co., Ltd.	2017-07-01	Not applicable	US
GD11 Rx SCM S	Adenosine Nicotinamide	Liquid	Topical	Coson Co., Ltd.	2017-07-01	Not applicable	US
Ginseng	Adenosine Nicotinamide	Cream	Topical	Synbio Co., Ltd.	2016-09-14	Not applicable	US
Ginseng Berry 80 Eye Essence	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-09-27	Not applicable	US
Ginseng Berry 80 Overnight Mask	Adenosine Nicotinamide	Cream	Topical	Ami Cosmetic Co.,Ltd.	2016-09-28	Not applicable	US
Ginseng Berry and Ginseng Callus Mask	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-08-01	Not applicable	US
Ginseng Royal Silk 120ml	Adenosine Nicotinamide	Emulsion	Topical	Nature Republic Co., Ltd.	2016-12-01	Not applicable	US
Ginseng Royal Silk Ampoule 17ml 4ea	Adenosine Nicotinamide	Solution	Topical	Nature Republic Co., Ltd.	2016-12-10	Not applicable	US
Ginseng Royal Silk Boosting Ampoule	Adenosine Nicotinamide	Solution / drops	Topical	Nature Republic Co., Ltd.	2016-12-20	Not applicable	US
Ginseng Royal Silk Cap Sule Essence	Adenosine Nicotinamide	Cream	Topical	Nature Republic Co., Ltd.	2016-12-20	Not applicable	US
Ginseng Royal Silk Eye 25ml	Adenosine Nicotinamide	Cream	Topical	Nature Republic Co., Ltd.	2016-12-01	Not applicable	US
Ginseng Royal Silk Gold Hydroge L Mask	Adenosine Nicotinamide	Patch	Topical	Nature Republic Co., Ltd.	2016-12-10	Not applicable	US
Ginseng Royal Silk Gold Hydroge L Mask 10p	Adenosine Nicotinamide	Patch	Topical	Nature Republic Co., Ltd.	2016-12-10	Not applicable	US
Ginseng Royal Silk Gold Hydroge L Mask 5p	Adenosine Nicotinamide	Patch	Topical	Nature Republic Co., Ltd.	2016-12-10	Not applicable	US
Ginseng Royal Silk Toner 120ml	Adenosine Nicotinamide	Liquid	Topical	Nature Republic Co., Ltd.	2016-12-01	Not applicable	US
Ginseng Royal Silk Watery 60g	Adenosine Nicotinamide	Cream	Topical	Nature Republic Co., Ltd.	2016-12-10	Not applicable	US
Ginseng Royal Silk Wrinkle Up Spot	Adenosine Nicotinamide	Cream	Topical	Nature Republic Co., Ltd.	2016-12-20	Not applicable	US
Green Propolis 90 Ampoule	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-09-28	Not applicable	US
Hanskin Bio Origin The	Adenosine Nicotinamide	Cream	Topical	Celltrion Skincure Co.,ltd.	2016-12-20	Not applicable	US
Hanskin Real Complexion Cre Am EX	Adenosine Nicotinamide	Cream	Topical	Celltrion Skincure Co.,ltd.	2017-07-01	Not applicable	US
Hanskin Vistra toner mask pad	Adenosine Nicotinamide	Liquid	Topical	Celltrion Skincure Co.,ltd.	2017-08-01	Not applicable	US
Hanskin Vstra toning water radiance	Adenosine Nicotinamide	Cream	Topical	Celltrion Skincure Co.,ltd.	2017-08-01	Not applicable	US
Hello Care Anti-wrinkle Ampoule Mask	Adenosine Nicotinamide	Patch	Topical	World Pack Co., Ltd.	2016-09-13	Not applicable	US
Hello Care Moisturizing Ampoule Mask	Adenosine Nicotinamide	Patch	Topical	World Pack Co., Ltd.	2016-08-01	Not applicable	US
Hello Care Pore and Sebum Ampoule Mask	Adenosine Nicotinamide	Patch	Topical	World Pack Co., Ltd.	2016-08-01	Not applicable	US
Hello Care Whitening Ampoule Mask	Adenosine Nicotinamide	Patch	Topical	World Pack Co., Ltd.	2016-09-13	Not applicable	US
Honesi exofila	Adenosine Nicotinamide	Cream	Topical	Originway Co., Ltd.	2017-02-01	Not applicable	US
Hydra Extra ConcentrateSerum	Adenosine Nicotinamide	Liquid	Topical	In This Morning	2017-02-08	Not applicable	US
Hydra Moisture Day and Night	Adenosine Nicotinamide	Cream	Topical	In This Morning	2017-02-08	Not applicable	US
Ideal Tone Up Glow Bb	Adenosine Nicotinamide Titanium dioxide Zinc oxide	Cream	Topical	In This Morning	2017-02-16	Not applicable	US
Jayjun Real Water Brightening Black Mask Step2 Jayjun Vita Snow Essence	Adenosine Allantoin Glycerin Nicotinamide	Liquid	Topical	Jayjun Cosmetic	2016-08-01	Not applicable	US
Jayjun Real Water Brightening Black Mask Step3 Real Water Brightening Black Mask	Adenosine Allantoin Glycerin Nicotinamide	Patch	Topical	Jayjun Cosmetic	2016-08-01	Not applicable	US
Limulus Bio Cellulose Mask	Adenosine Glycerin Nicotinamide	Kit		Skin R&d	2017-06-28	Not applicable	US
Limulus Deep Sea Moisture	Adenosine Nicotinamide	Cream	Topical	Skin R&d	2017-05-01	Not applicable	US
Limulus The 1 and Only	Adenosine Nicotinamide	Lotion	Topical	Skin R&d	2017-05-01	Not applicable	US
Lip And Hand Camellia	Adenosine Nicotinamide	Cream	Topical	Tov Co., Ltd	2016-11-08	Not applicable	US
Lip And Hand Shea Butter	Adenosine Nicotinamide	Cream	Topical	Tov Co., Ltd	2016-11-08	Not applicable	US
Lip And Hand Wild Rose	Adenosine Nicotinamide	Cream	Topical	Tov Co., Ltd	2016-11-08	Not applicable	US
Lohasys Mayu Ultra Moisture	Adenosine Glycerin	Emulsion	Topical	Netcos Co., Ltd.	2017-09-13	Not applicable	US
Lohasys Mayu Ultra Moisture Care	Adenosine Glycerin	Cream	Topical	Netcos Co., Ltd.	2017-09-13	Not applicable	US
Lohasys Mayu Ultra Moisture Care Hand	Adenosine Glycerin	Cream	Topical	Netcos Co., Ltd.	2017-09-13	Not applicable	US
Lohasys Mayu Ultra Moisture Care Toner	Adenosine Glycerin	Liquid	Topical	Netcos Co., Ltd.	2017-09-13	Not applicable	US
Maxclinic Deep and Deeper Meso Change Ampoule	Adenosine Nicotinamide	Liquid	Topical	N&b lab.co.ltd	2016-12-20	Not applicable	US
Maxclinic Miraclinic Contour Ing Object	Adenosine Nicotinamide	Patch	Topical	N&b lab.co.ltd	2016-11-01	Not applicable	US
Medi Hydro DP B Tox Ampoule	Adenosine Nicotinamide	Liquid	Topical	Mbg Inc (Korea Institute of Science Development)	2016-08-08	2017-08-08	US
Medi Hydro DP BB Cream	Adenosine Aluminum hydroxide Nicotinamide Stearic acid Titanium dioxide	Cream	Topical	Mbg Inc (Korea Institute of Science Development)	2016-08-08	2017-08-08	US
Medi Hydro DP Cream	Adenosine Nicotinamide	Cream	Topical	Mbg Inc (Korea Institute of Science Development)	2016-08-15	2017-08-15	US
Medi Hydro DP Emulsion	Adenosine Nicotinamide	Liquid	Topical	Mbg Inc (Korea Institute of Science Development)	2016-08-08	2017-08-08	US
Medi Hydro DP Stem C Ampoule	Adenosine Nicotinamide	Liquid	Topical	Mbg Inc (Korea Institute of Science Development)	2016-08-08	2017-08-08	US
Medi Hydro DP Toner	Adenosine Nicotinamide	Liquid	Topical	Mbg Inc (Korea Institute of Science Development)	2016-08-08	2017-08-08	US
Medi Hydro DP Vita C Ampoule	Adenosine Nicotinamide	Liquid	Topical	Mbg Inc (Korea Institute of Science Development)	2016-08-15	2017-08-15	US
Miesoo Perfect Pure Seed	Adenosine Nicotinamide	Emulsion	Topical	C&bcosmetic Co.,ltd.	2017-02-20	Not applicable	US
Miesoo Perfect Pure Seed Cycling Ampoule	Adenosine Nicotinamide	Gel	Topical	C&bcosmetic Co.,ltd.	2017-02-20	Not applicable	US
Miesoo Perfect Pure Seed Essence	Adenosine Nicotinamide	Gel	Topical	C&bcosmetic Co.,ltd.	2017-02-20	Not applicable	US
Miesoo Perfect Pure Seed Toner	Adenosine Nicotinamide	Liquid	Topical	C&bcosmetic Co.,ltd.	2017-02-20	Not applicable	US
MIRACLETOX Time Rewind Advanced Essential Toner	Adenosine Nicotinamide	Liquid	Topical	Beauren Korea Inc.	2017-08-01	Not applicable	US
MIRACLETOX Time Rewind Advanced Feel	Adenosine Nicotinamide	Cream	Topical	Beauren Korea Inc.	2017-08-01	Not applicable	US
MIRACLETOX Time Rewind Advanced Lifting Ampoule	Adenosine Nicotinamide	Liquid	Topical	Beauren Korea Inc.	2017-08-01	Not applicable	US
MIRACLETOX Time Rewind Advanced Mask	Adenosine Nicotinamide	Patch	Topical	Beauren Korea Inc.	2017-08-01	Not applicable	US
MIRACLETOX Time Rewind Advanced Meso Tox	Adenosine Nicotinamide	Liquid	Topical	Beauren Korea Inc.	2017-08-01	Not applicable	US
MIRACLETOX Time Rewind Advanced TOX Ampoule	Adenosine Nicotinamide	Liquid	Topical	Beauren Korea Inc.	2017-08-01	Not applicable	US
Moistie Cell Plus	Adenosine Nicotinamide	Cream	Topical	Purecell Korea Co., Ltd.	2017-06-01	Not applicable	US
Moistie Fill Plus	Adenosine Nicotinamide	Cream	Topical	Purecell Korea Co., Ltd.	2017-06-01	Not applicable	US
Moistie Tok Plus	Adenosine Nicotinamide	Cream	Topical	Purecell Korea Co., Ltd.	2017-06-01	Not applicable	US
MU LAB TURN AROUND 2W Refresh Ex	Adenosine Nicotinamide	Cream	Topical	Mu biz.co,.ltd	2016-12-01	Not applicable	US
Natural Sun AQ Total Anti-aging Essence Sun	Adenosine Avobenzone Enzacamene Nicotinamide Octinoxate Octisalate Titanium dioxide	Cream	Topical	Thefaceshop Co., Ltd.	2010-11-22	Not applicable	US
Neogen Agecure 3d Lifting Compression Span Tex Mask	Adenosine Nicotinamide	Patch	Topical	Outin Futures Corp.	2017-02-01	Not applicable	US
Neogen Agecure 3d Lifting Wrinkle Neck Mask	Adenosine Nicotinamide	Patch	Topical	Outin Futures Corp.	2017-01-03	Not applicable	US
Neogen Agecure One Minute Wrinkle Rx	Adenosine Nicotinamide	Cream	Topical	Outin Futures Corp.	2016-01-20	Not applicable	US
Neogen Code 9 Black Volume	Adenosine Nicotinamide	Cream	Topical	Outin Futures Corp.	2017-06-01	Not applicable	US
Neogen Code9 Gold Black Caviar Essence	Adenosine Nicotinamide	Cream	Topical	Outin Futures Corp.	2015-07-07	2017-05-26	US
Neogen Code9 Lemon Green Caviar Essence	Adenosine Nicotinamide	Cream	Topical	Outin Futures Corp.	2015-07-07	2017-08-30	US
Neogen Dermalogy H2 Dermadeca Serum	Adenosine Nicotinamide	Spray	Topical	Outin Futures Corp.	2016-11-01	Not applicable	US
Neogen Dermalogy Pink Cactus Liftmax Knit Mask	Adenosine Nicotinamide	Patch	Topical	Outin Futures Corp.	2016-12-20	Not applicable	US
Neogen Dermalogy White Truffle Hydramax Knit Mask	Adenosine Nicotinamide	Patch	Topical	Outin Futures Corp.	2016-12-20	Not applicable	US
Neogen Dermalogy White Truffle Serum In Oi L Drop	Adenosine Nicotinamide	Oil	Topical	Outin Futures Corp.	2016-10-10	Not applicable	US
NoTS Special Collagen Real Skin Mask	Adenosine Glycerin	Patch	Topical	No Ts Co.,Ltd	2016-07-01	Not applicable	US
P1P Chitosan V-mask	Adenosine Dexpanthenol Nicotinamide	Patch	Topical	Phytos Co., Ltd.	2015-01-26	Not applicable	US
P1P Magic Whitening Antiaging	Adenosine Dexpanthenol Nicotinamide	Liquid	Topical	Phytos Co., Ltd.	2015-01-26	Not applicable	US
P1P Skin Rebirth Cream	Adenosine Dimethicone	Cream	Topical	Phytos Co., Ltd.	2015-01-26	Not applicable	US
Peptide Volume Essence Premium	Adenosine Nicotinamide	Cream	Topical	J&coceu Co Ltd	2017-08-23	Not applicable	US
Plalab Placenta Ample Essence	Adenosine Nicotinamide	Liquid	Topical	Renocell Co., Ltd	2015-12-23	Not applicable	US
Plalab Placenta Mask	Adenosine Nicotinamide	Patch	Topical	Renocell Co., Ltd	2015-12-23	Not applicable	US
Plalab Placenta R-20	Adenosine Nicotinamide	Cream	Topical	Renocell Co., Ltd	2015-12-23	Not applicable	US
Plalab Placenta Skin Booster	Adenosine Nicotinamide	Liquid	Topical	Renocell Co., Ltd	2015-12-23	Not applicable	US
Premium Dr. Althea Power Whitening Glutathione Mask	Adenosine Nicotinamide	Liquid	Topical	Dr. Althea	2016-08-01	Not applicable	US
Premium Dr. Althea Water Glow Skin Renewal Hydrogel Mask	Adenosine Nicotinamide	Liquid	Topical	Dr. Althea	2016-08-01	Not applicable	US
Prestige Caviar Full Intensive Vitality Toner	Adenosine Nicotinamide	Liquid	Topical	Fw1 R&D Branch	2016-03-08	Not applicable	US
Prestige Caviar Super Aqua Serum	Adenosine Nicotinamide	Cream	Topical	Fw1 R&D Branch	2016-03-10	Not applicable	US
Prestige Snail Repairing	Adenosine Nicotinamide	Cream	Topical	Zenpia	2015-07-05	Not applicable	US
Prestige Snail Repairing Ampoule	Adenosine Nicotinamide	Liquid	Topical	Zenpia	2015-07-05	Not applicable	US
Prestige Snail Repairing Booster	Adenosine Nicotinamide	Liquid	Topical	Zenpia	2015-07-05	Not applicable	US
Primerose Double Effect Eye	Adenosine Nicotinamide	Cream	Topical	Royal Springs Cosmetics Usa, Llc	2016-03-15	Not applicable	US
Primerose Egf	Adenosine Dimethicone Nicotinamide	Cream	Topical	Royal Springs Cosmetics Usa, Llc	2015-06-08	Not applicable	US
Primerose White Milky Cb	Adenosine Dexpanthenol Dimethicone Nicotinamide	Cream	Topical	Royal Springs Cosmetics Usa, Llc	2015-06-22	Not applicable	US
Propolis 20 BB Cream	Adenosine Arbutin Octinoxate Octisalate Titanium dioxide	Cream	Topical	Ami Cosmetic Co.,Ltd.	2016-02-23	Not applicable	US
Propolis 27 Cover Cushion	Adenosine Nicotinamide Octinoxate Octisalate Octocrylene Titanium dioxide Zinc oxide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2015-07-05	Not applicable	US
Propolis 50 Volume Mist	Adenosine Nicotinamide Propolis wax	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-09-01	Not applicable	US
Propolis 80	Adenosine Nicotinamide Propolis wax	Cream	Topical	Ami Cosmetic Co.,Ltd.	2016-08-30	Not applicable	US
Propolis 80 Sleeping Pack	Adenosine Nicotinamide Propolis wax	Cream	Topical	Ami Cosmetic Co.,Ltd.	2016-08-30	Not applicable	US
Propolis and Rose Callus Mask	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-08-01	Not applicable	US
Propolis Softening Toner	Adenosine Nicotinamide Propolis wax	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-08-30	Not applicable	US
Protective Base Sun for Dry Skin	Adenosine Nicotinamide Titanium dioxide Zinc oxide	Cream	Topical	In This Morning	2017-02-08	Not applicable	US
Protective Base Sun for Oily Skin	Adenosine Nicotinamide Titanium dioxide Zinc oxide	Cream	Topical	In This Morning	2017-02-08	Not applicable	US
Pure C Serum	Adenosine Nicotinamide	Liquid	Topical	R&L Co., Ltd.	2016-12-29	Not applicable	US
Queen Purecell Whitening 3-step Mask	Adenosine Nicotinamide	Kit		Purecell Korea Co., Ltd.	2017-06-01	Not applicable	US
Queens Rose Recovery	Adenosine Nicotinamide	Emulsion	Topical	Cdpharmtec Co.,ltd	2017-03-02	Not applicable	US
Queens Rose Recovery Eye	Adenosine Nicotinamide	Cream	Topical	Cdpharmtec Co.,ltd	2017-03-02	Not applicable	US
Queens Rose Recovery Toner	Adenosine Nicotinamide	Liquid	Topical	Cdpharmtec Co.,ltd	2017-03-02	Not applicable	US
rep Nutrinature Ultra All in One Multitem	Adenosine Nicotinamide	Cream	Topical	Outin Futures Corp.	2015-07-07	Not applicable	US
rep Nutrinature Ultra Moist Ge l	Adenosine Nicotinamide	Oil	Topical	Outin Futures Corp.	2015-07-07	Not applicable	US
rep Nutrinature Ultra Moist Gel Oil	Adenosine Nicotinamide	Oil	Topical	Outin Futures Corp.	2015-07-07	Not applicable	US
Rep Nutrinature Ultra Nourishing	Adenosine Nicotinamide	Cream	Topical	Outin Futures Corp.	2015-11-24	Not applicable	US
rep Nutrinature Ultra Nourishing Cream	Adenosine Nicotinamide	Cream	Topical	Outin Futures Corp.	2015-11-24	Not applicable	US
rep Nutrinature Ultra-All-Night Moisture Relief Mask	Adenosine Nicotinamide	Cream	Topical	Outin Futures Corp.	2015-07-07	Not applicable	US
Rose Oasis 50 Moisture Bomb	Adenosine Nicotinamide	Cream	Topical	Ami Cosmetic Co.,Ltd.	2016-08-01	Not applicable	US
Rose Oasis 70 Cream	Adenosine Nicotinamide	Cream	Topical	Ami Cosmetic Co.,Ltd.	2016-08-01	Not applicable	US
Rose Oasis 80 Ampoule	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-08-01	Not applicable	US
RUBELLI Black Pearl Mask	Adenosine Nicotinamide	Patch	Topical	Rubelli Co.,ltd	2017-06-01	Not applicable	US
Ruby Cell 4u	Adenosine Nicotinamide	Cream	Topical	Dasan E&T Co., Ltd.	2015-03-01	Not applicable	US
Ruby Cell 4u Ampoule	Adenosine Nicotinamide	Solution	Topical	Dasan E&T Co., Ltd.	2015-03-01	Not applicable	US
Ruby Cell 4u Ampoule Premium	Adenosine Nicotinamide	Solution	Topical	Dasan E&T Co., Ltd.	2015-03-01	Not applicable	US
Secret Key Thanakha Mild SunCream SPF47 PA PLUS PLUS PLUS	Adenosine Nicotinamide Titanium dioxide Zinc oxide	Cream	Topical	Zenpia	2017-06-01	Not applicable	US
Sheza Gusl Firming Mask Pack	Adenosine Nicotinamide	Cream	Topical	Pisatap	2013-08-09	Not applicable	US
Siseundeusi Luminant	Adenosine Nicotinamide	Emulsion	Topical	Gk Cosmetic Co., Ltd.	2017-02-06	Not applicable	US
Siseundeusi Luminant Essence	Adenosine Nicotinamide	Liquid	Topical	Gk Cosmetic Co., Ltd.	2017-05-01	Not applicable	US
Siseundeusi Luminant Skin Toner	Adenosine Nicotinamide	Liquid	Topical	Gk Cosmetic Co., Ltd.	2017-02-06	Not applicable	US
Skin-ion	Adenosine Arbutin Glycerin	Spray	Topical	Wako Korea Corp	2010-01-01	Not applicable	US
Skinfood Miracle Food 10 Solu Tion	Adenosine Glycerin Nicotinamide	Emulsion	Topical	Skinfood Co., Ltd.	2016-04-01	Not applicable	US
Skinfood Miracle Food 10 Solu Tion 1ml	Adenosine Glycerin Nicotinamide	Emulsion	Topical	Skinfood Co., Ltd.	2016-04-01	Not applicable	US
Skinfood Real Tea Ge L Mask Chamomile	Adenosine Glycerin Nicotinamide	Patch	Topical	Skinfood Co., Ltd.	2016-04-01	Not applicable	US
Skinfood Real Tea Ge L Mask Lavender	Adenosine Glycerin Nicotinamide	Patch	Topical	Skinfood Co., Ltd.	2016-04-01	Not applicable	US
Skinfood Real Tea Ge L Mask Rose	Adenosine Glycerin Nicotinamide	Patch	Topical	Skinfood Co., Ltd.	2016-04-01	Not applicable	US
Snail Skin Booster	Adenosine Nicotinamide	Cream	Topical	Nature Republic Co., Ltd.	2015-02-01	Not applicable	US
Snail Solu Tion Skin Booster	Adenosine Nicotinamide	Cream	Topical	Nature Republic Co., Ltd.	2015-02-01	Not applicable	US
Snail Solu Tion Wrinkle Up Spot	Adenosine Nicotinamide	Cream	Topical	Nature Republic Co., Ltd.	2016-12-01	Not applicable	US
Sollume Esthe Repair Serum	Adenosine Nicotinamide	Gel	Topical	G&j Co., Ltd.	2017-05-01	Not applicable	US
Super Amazing Revolution For Eye	Adenosine Nicotinamide	Cream	Topical	Aimeeskinlab Co., Ltd.	2017-08-01	Not applicable	US
Super Amazing Revolution For Face	Adenosine Nicotinamide	Cream	Topical	Aimeeskinlab Co., Ltd.	2017-08-01	Not applicable	US
Super Plus Beblesh Balm Triple Functions SPF50 Plus PA 3Plus (40g)	Adenosine Amiloxate Arbutin Octinoxate Titanium dioxide Zinc oxide	Cream	Topical	Wizcoz Corporation Ltd	2011-12-01	Not applicable	US
SuperPlus Beblesh Balm Gold SPF25 PA 2Plus	Adenosine Arbutin Titanium dioxide Zinc oxide	Cream	Topical	Wizcoz Corporation Ltd	2011-12-01	Not applicable	US
SuperPlus Beblesh Balm SPF25 PA 2Plus	Adenosine Arbutin Titanium dioxide Zinc oxide	Cream	Topical	Wizcoz Corporation Ltd	2012-02-01	Not applicable	US
SuperPlus Beblesh Balm Triple Functions SPF25 PA 2Plus	Adenosine Arbutin Octinoxate Octisalate Titanium dioxide Zinc oxide	Cream	Topical	Wizcoz Corporation Ltd	2011-12-01	Not applicable	US
TAMHADA Synergy Anti Wrinkle Face And Neck Mask	Adenosine Glycerin	Patch	Topical	Taenam Medicos Co., Ltd	2016-10-01	Not applicable	US
Tangerine Bright Sleeping Mask	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-02-23	Not applicable	US
Thanks 12 Rich Caviar Mask	Adenosine Allantoin Glycerin Nicotinamide	Patch	Topical	Hyundai Ibt Co., Ltd.	2016-10-10	Not applicable	US
Thanks 12 Rich Caviar Mist	Adenosine Allantoin Nicotinamide	Spray	Topical	Hyundai Ibt Co., Ltd.	2016-10-10	Not applicable	US
The All Medicare V PLA Synergy Anti Wrinkle Face And Neck Mask	Adenosine Glycerin	Patch	Topical	Taenam Medicos Co., Ltd	2016-07-01	Not applicable	US
The Barafu Intensive Serum	Adenosine Allantoin Dexpanthenol	Liquid	Topical	Bioresource Co., Ltd	2016-12-05	Not applicable	US
The Oozoo Face Energy Shot Premium Black Ampoule1	Adenosine Nicotinamide	Liquid	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Face Energy Shot Premium Black Ampoule2	Adenosine Nicotinamide	Liquid	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oozoo Face Energy Shot Premium Black Mask	Adenosine Nicotinamide	Patch	Topical	The Oozoo Co. Ltd	2017-03-15	Not applicable	US
The Oriental Gold BB SPF25 PA 2Plus	Adenosine Arbutin Titanium dioxide Zinc oxide	Cream	Topical	Wizcoz Corporation Ltd	2011-12-01	Not applicable	US
The Prestige BB SPF25 PA 2Plus	Adenosine Arbutin Titanium dioxide Zinc oxide	Cream	Topical	Wizcoz Corporation Ltd	2011-12-01	Not applicable	US
Uniwell Natural	Adenosine Nicotinamide	Cream	Topical	Uniwell Ltd	2017-06-13	Not applicable	US
Uniwell Natural Toner	Adenosine Nicotinamide	Liquid	Topical	Uniwell Ltd	2017-06-13	Not applicable	US
Vita Volu 101 Essence	Adenosine Dexpanthenol Nicotinamide	Liquid	Topical	B&p Cosmetic, Inc.	2017-03-02	Not applicable	US
Vita Volu Volume Booster	Adenosine Nicotinamide	Liquid	Topical	B&p Cosmetic, Inc.	2017-03-02	Not applicable	US
Vitabrid C12 FACE 4g	Adenosine Allantoin Nicotinamide	Powder	Topical	Hyundai Ibt Co., Ltd.	2016-12-01	Not applicable	US
Vitabrid C12 FACE BRIGHTENING	Adenosine Allantoin Nicotinamide	Powder	Topical	Hyundai Ibt Co., Ltd.	2016-09-01	Not applicable	US
Vitabrid C12 FACE Pow der 2g	Adenosine Allantoin Nicotinamide	Powder	Topical	Hyundai Ibt Co., Ltd.	2016-12-01	Not applicable	US
Vitabrid C12 FACE Pow der 3g	Adenosine Allantoin Arbutin	Powder	Topical	Hyundai Ibt Co., Ltd.	2016-12-01	Not applicable	US
Vitabrid C12 SENSITIVE Spot Pow der Serum	Adenosine Nicotinamide	Powder	Topical	Hyundai Ibt Co., Ltd.	2016-10-10	Not applicable	US
Volcanic Grape Callus Mask	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-08-01	Not applicable	US
Volcanic Homme	Adenosine Nicotinamide	Emulsion	Topical	Ami Cosmetic Co.,Ltd.	2016-08-01	Not applicable	US
Volcanic Homme All in One Essence	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-08-01	Not applicable	US
Volcanic Homme Toner	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-08-01	Not applicable	US
Volcanic Pore Eraser Ampoule	Adenosine Nicotinamide	Liquid	Topical	Ami Cosmetic Co.,Ltd.	2016-08-01	Not applicable	US
Wellage Deep Layer Fresh Moisture	Adenosine Nicotinamide	Cream	Topical	Hugel Pharma Co.,Ltd.	2016-09-08	Not applicable	US
Wellage Fresh Water Essence Mist	Adenosine Nicotinamide	Liquid	Topical	Hugel Pharma Co.,Ltd.	2016-09-08	Not applicable	US
White Lie	Adenosine Nicotinamide	Cream	Topical	Samsung Cosmetics Co., Ltd.	2016-09-13	Not applicable	US
Wisderma Most Moist Bio Ampoule	Adenosine Nicotinamide	Solution	Topical	Kolon Wellcare Co.,ltd.	2017-06-01	Not applicable	US
Yenaan Jinaek	Adenosine Nicotinamide	Cream	Topical	Yenaan Cosmetics	2017-03-02	Not applicable	US
Yenaan Jinaek Essence	Adenosine Nicotinamide	Liquid	Topical	Yenaan Cosmetics	2017-03-02	Not applicable	US
Yenaan Jinaek Eye	Adenosine Nicotinamide	Cream	Topical	Yenaan Cosmetics	2017-03-02	Not applicable	US

Categories

UNII

K72T3FS567

CAS number

58-61-7

Weight

Average: 267.2413
Monoisotopic: 267.096753929

Chemical Formula

C₁₀H₁₃N₅O₄

InChI Key

OIRDTQYFTABQOQ-KQYNXXCUSA-N

InChI

InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1

IUPAC Name

(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

SMILES

NC1=C2N=CN([[email protected]@H]3O[[email protected]](CO)[[email protected]@H](O)[[email protected]]3O)C2=NC=N1

Pharmacology

Indication

Used as an initial treatment for the termination of paroxysmal supraventricular tachycardia (PVST), including that associated with accessory bypass tracts, and is a drug of choice for terminating stable, narrow-complex supraventricular tachycardias (SVT). Also used as an adjunct to thallous chloride TI 201 myocardial perfusion scintigraphy (thallium stress test) in patients who are unable to exercise adequately, as well as an adjunct to vagal maneuvers and clinical assessment to establish a specific diagnosis of undefined, stable, narrow-complex SVT.

Structured Indications

Pharmacodynamics

Adenosine is an endogenous nucleoside occurring in all cells of the body and is not chemically related to other antiarrhythmic drugs. Adenosine may exert its pharmacologic effects by activation of purine (cell surface A₁ and A₂ adenosine) receptors, as well as relax vascular smooth muscles through the reduction in calcium uptake by inhibition of slow inward calcium current and activation of adenylate cyclase in smooth muscle cells. Adenosine may reduce vascular tone by modulation of sympathetic neurotransmission. The drug also has negative chronotropic, dromotropic, and inotropic effects on the heart by slowing conduction time throught he AV node and interrupting AV nodal reentry pathways. Adenosine is a potent vasodilator in most vascular beds, but vasoconstriction is produced in renal afferent arterioles and hepatic veins. The drug produces a net mild to moderate reduction in systolic, diastolic, and mean arterial blood pressure and a reflex increase in heart rate. Adenosine is antagonized competitively by methylxanthines such as caffeine and theophylline, and potentiated by blockers of nucleoside transport such as dipyridamole. Adenosine is not blocked by atropine.

Mechanism of action

Adenosine slows conduction time through the AV node and can interrupt the reentry pathways through the AV node, resulting in the restoration of normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT), including PSVT associated with Wolff-Parkinson-White Syndrome. This effect may be mediated through the drug's activation of cell-surface A₁ and A₂ adenosine receptors. Adenosine also inhibits the slow inward calcium current and activation of adenylate cyclase in smooth muscle cells, thereby causing relaxation of vascular smooth muscle. By increasing blood flow in normal coronary arteries with little or no increase in stenotic arteries (with little to no increase in stenotic arteries), adenosine produces a relative difference in thallous (thallium) chloride TI 201 uptake in myocardium supplied by normal verus stenotic coronary arteries.

Target	Kind	Pharmacological action	Actions	Organism	UniProt ID
Adenosine receptor A2a	Protein	yes	agonist	Human	P29274	details
Adenosine receptor A2b	Protein	yes	agonist	Human	P29275	details
Adenosine receptor A3	Protein	yes	agonist	Human	P0DMS8	details
Adenosine receptor A1	Protein	yes	agonist	Human	P30542	details

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Intracellular adenosine is rapidly metabolized either via phosphorylation to adenosine monophosphate by adenosine kinase, or via deamination to inosine by adenosine deaminase in the cytosol.

Substrate	Enzymes	Product
Adenosine	Not Available	Adenosine monophosphate	Details
Adenosine	Not Available	Inosine	Details

Route of elimination

Not Available

Half life

Less than 10 secs

Clearance

Not Available

Toxicity

Not Available

Affected organisms

Humans and other mammals

Pathways

Pathway	Category	SMPDB ID
Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)	Disease	SMP00340
Lesch-Nyhan Syndrome (LNS)	Disease	SMP00364
Myoadenylate deaminase deficiency	Disease	SMP00537
AICA-Ribosiduria	Disease	SMP00168
Mercaptopurine Action Pathway	Drug action	SMP00428
Thioguanine Action Pathway	Drug action	SMP00430
Xanthinuria type I	Disease	SMP00512
Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type	Disease	SMP00570
Betaine Metabolism	Metabolic	SMP00123
Cystathionine Beta-Synthase Deficiency	Disease	SMP00177
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine	Signaling	SMP00320
Gout or Kelley-Seegmiller Syndrome	Disease	SMP00365
Azathioprine Action Pathway	Drug action	SMP00427
Xanthinuria type II	Disease	SMP00513
Selenoamino Acid Metabolism	Metabolic	SMP00029
Methionine Metabolism	Metabolic	SMP00033
Purine Metabolism	Metabolic	SMP00050
Adenosine Deaminase Deficiency	Disease	SMP00144
Xanthine Dehydrogenase Deficiency (Xanthinuria)	Disease	SMP00220
Methionine Adenosyltransferase Deficiency	Disease	SMP00221
Hypermethioninemia	Disease	SMP00341
Adenylosuccinate Lyase Deficiency	Disease	SMP00167
Molybdenum Cofactor Deficiency	Disease	SMP00203
Purine Nucleoside Phosphorylase Deficiency	Disease	SMP00210
S-Adenosylhomocysteine (SAH) Hydrolase Deficiency	Disease	SMP00214
Glycine N-methyltransferase Deficiency	Disease	SMP00222
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine	Signaling	SMP00321
Adenine phosphoribosyltransferase deficiency (APRT)	Disease	SMP00535
Mitochondrial DNA depletion syndrome	Disease	SMP00536

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

Drug	Interaction	Drug group
Ambroxol acefyllinate	The therapeutic efficacy of Adenosine can be decreased when used in combination with Ambroxol acefyllinate.	Experimental
Aminophylline	The therapeutic efficacy of Adenosine can be decreased when used in combination with Aminophylline.	Approved
Caffeine	The therapeutic efficacy of Adenosine can be decreased when used in combination with Caffeine.	Approved
Carbamazepine	The risk or severity of adverse effects can be increased when Carbamazepine is combined with Adenosine.	Approved, Investigational
Digoxin	The risk or severity of adverse effects can be increased when Digoxin is combined with Adenosine.	Approved
Dipyridamole	The risk or severity of adverse effects can be increased when Dipyridamole is combined with Adenosine.	Approved
Dyphylline	The therapeutic efficacy of Adenosine can be decreased when used in combination with Dyphylline.	Approved
Nicotine	Nicotine may increase the atrioventricular blocking (AV block) activities of Adenosine.	Approved
Theophylline	The therapeutic efficacy of Adenosine can be decreased when used in combination with Theophylline.	Approved

Food Interactions

Avoid caffeine containing foods and drinks.

References

Synthesis Reference

Giorgio Stramentinoli, Federico Gennari, "Process for preparing adenosine derivatives of anti-inflammatory and analgesic activity." U.S. Patent US4373097, issued October, 1965.

US4373097

General References

Not Available

External Links

Resource	Link
Human Metabolome Database (HMDB)	HMDB00050
KEGG Drug	D00045
KEGG Compound	C00212
PubChem Compound	60961
PubChem Substance	46508728
ChemSpider	54923
BindingDB	14487
ChEBI	16335
ChEMBL	CHEMBL477
Therapeutic Targets Database	DAP000223
PharmGKB	PA448049
HET	ADN
Drug Product Database	4732
RxList	http://www.rxlist.com/cgi/generic3/adenos.htm
Drugs.com	http://www.drugs.com/cdi/adenosine.html
Wikipedia	Adenosine

ATC Codes

C01EB10 — Adenosine

AHFS Codes

92:00.00

PDB Entries

Not Available

FDA label

Download (154 KB)

MSDS

Download (72.7 KB)

Clinical Trials

Phase	Status	Purpose	Conditions	Count
0	Completed	Basic Science	Blood Pressures / Cognition	1
0	Completed	Diagnostic	Myocardial Ischemia / Vascular Diseases	1
1	Completed	Not Available	Coronary Artery Disease	1
1	Completed	Diagnostic	Coronary Artery Disease	1
1	Completed	Treatment	Atrioventricular Block / Sinus Bradycardia	1
1	Terminated	Other	Inflammatory Reaction	1
1, 2	Completed	Treatment	Adenosine / Cardiac Surgical Procedures / Heart Defects,Congenital / Myocardial Reperfusion Injury	1
1, 2	Completed	Treatment	Angina Pectoris	1
1, 2	Unknown Status	Not Available	Neoplasms, Hepatic	1
2	Active Not Recruiting	Treatment	Cancer, Breast	1
2	Completed	Prevention	ST Elevation Myocardial Infarction (STEMI)	1
2	Completed	Treatment	Healthy Volunteers	1
2	Completed	Treatment	Nonvalvular Atrial Fibrillation	1
2	Completed	Treatment	Pain	1
2	Completed	Treatment	Perioperative Pain	1
2	Completed	Treatment	Tiredness	1
2	Not Yet Recruiting	Treatment	Microvascular coronary artery disease	1
2	Recruiting	Prevention	Pathological Processes / Prophylaxis of cardiomyopathy	1
2	Recruiting	Treatment	Takotsubo Cardiomyopathy	1
2	Unknown Status	Not Available	Ischaemic Heart Diseases	1
2	Unknown Status	Treatment	Acute ST Elevation Myocardial Infarction	1
2, 3	Completed	Diagnostic	Coronary Artery Atherosclerosis / Heart Disease, Ischemic	1
2, 3	Completed	Treatment	Myocardial Infarction (MI)	1
3	Completed	Diagnostic	Coronary Artery Disease	5
3	Completed	Diagnostic	Orthotopic Heart Transplant	1
3	Completed	Prevention	Coronary Angioplasty	1
3	Completed	Treatment	Acute Myocardial Infarction (AMI)	1
3	Terminated	Diagnostic	Coronary Artery Disease	2
3	Terminated	Prevention	Coronary Artery Disease / Coronary Artery Stenosis	1
3	Unknown Status	Treatment	Percutaneous Coronary Intervention (PCI) / Stable Angina (SA)	1
4	Recruiting	Diagnostic	Premature Ventricular Contraction (PVC)	1
4	Recruiting	Treatment	Resistant Hypertension	1
Not Available	Completed	Not Available	Coronary Artery Disease	1
Not Available	Completed	Not Available	Type 2 Diabetes Mellitus	1
Not Available	Completed	Diagnostic	BMI >30 kg/m2 / Decreased Vascular Flow / Endothelial Dysfunction	1
Not Available	Completed	Diagnostic	Coronary Artery Disease	2
Not Available	Completed	Screening	Diabetes Mellitus, Insulin-Dependent / Ischemia-Reperfusion Injury	1
Not Available	Completed	Supportive Care	Neoplasms, Breast / Neoplasms, Lung	1
Not Available	Completed	Treatment	Heart Failure, Unspecified / Peripheral Chemoreceptor Hypersensitivity	1
Not Available	Completed	Treatment	Microcirculation / Physiology, Ocular	1
Not Available	Recruiting	Not Available	Coronary Artery Disease / Coronary Microvascular Disease	1
Not Available	Recruiting	Health Services Research	MRI Scans	1
Not Available	Suspended	Not Available	Ischemia-Reperfusion Injury	1
Not Available	Suspended	Not Available	Transient ischemia attacks	1
Not Available	Unknown Status	Diagnostic	Atherosclerosis / Endothelial Dysfunction / Inflammatory Reaction / Myocardial Ischemia	1
Not Available	Unknown Status	Treatment	Tachycardia, Supraventricular	1

Pharmacoeconomics

Manufacturers

Astellas pharma us inc
Akorn inc
App pharmaceuticals llc
Baxter healthcare corp
Bedford laboratories div ben venue laboratories inc
Gland pharma ltd
Luitpold pharmaceuticals inc
Strides arcolab ltd
Teva parenteral medicines inc
Wockhardt ltd

Packagers

Dosage forms

Form	Route	Strength
Cream	Topical	.12 mg/30mL
Liquid	Topical	48 mg/120mL
Solution	Intravenous	6 mg/2mL
Liquid	Intravenous	3 mg
Solution	Intravenous	3 mg/mL
Injection	Intravenous	3 mg/mL
Injection, solution	Intravenous	3 mg/mL
Cream	Topical	.04 mg/100mL
Cream	Topical	.4 mg/mL
Cream	Topical	20 mg/50mL
Liquid	Topical	12.8 mg/32g
Liquid	Topical	12 mg/30mL
Liquid	Topical	54 mg/135mL
Liquid	Topical
Liquid	Topical	12 mg/30g
Solution	Topical	.002 g/6mL
Solution	Topical	2.8 mg/7mL
Liquid	Topical	.012 g/30mL
Gel	Topical
Cream	Topical	.04 g/100mL
Liquid	Topical	.05 g/130mL
Cream	Topical	.01 g/45mL
Cream	Topical	.02 g/50mL
Cream	Topical	.01 g/30mL
Solution	Topical	1.2 mg/3mL
Patch	Topical	.008 g/20g
Liquid	Topical	.6 mg/6mL
Cream	Topical	.04 mL/100mL
Cream	Topical	.004 g/10g
Gel	Topical	.04 g/100g
Cream	Topical	.03 g/95g
Liquid	Topical	20 mg/50mL
Gel	Topical	.04 g/100mL
Cream	Topical	.04 g/100g
Liquid	Topical	6 mg/15mL
Liquid	Topical	.04 g/100mL
Emulsion	Topical	.04 g/100g
Solution / drops	Topical
Cream	Topical
Liquid	Topical	.04 g/100g
Kit	Topical
Cream	Topical	.0428 g/100g
Kit	Topical
Cream	Topical	.2 g/100g
Liquid	Topical	2 mg/5mL
Patch	Topical	.01 g/25g
Liquid	Topical	25 mg/50mL
Liquid	Topical	.02 g/50mL
Cream	Topical	.0004 mL/mL
Liquid	Topical	.0004 mL/mL
Cream	Topical	.0004 g/g
Emulsion	Topical	.04 g/100mL
Kit
Lotion	Topical
Patch	Topical	.5 g/25g
Cream	Topical	6 g/150g
Cream	Topical	.004 mg/10g
Cream	Topical	.08 mg/20mL
Patch	Topical	.6 mg/3g
Cream	Topical	.02 mg/50mL
Liquid	Topical	.05 mg/125mL
Patch	Topical	.014 g/35g
Cream	Topical	.01 g/27g
Liquid	Topical	.04 mg/100mL
Lipstick	Topical	.001 g/3.5g
Patch	Topical
Liquid	Topical	.00012 mg/.3mL
Cream	Topical	.00012 mg/.3mL
Cream	Topical	.011 mg/27mL
Cream	Topical	.001 mg/2.5mL
Oil	Topical	.01 g/30mL
Solution	Intravenous	3 mg
Cream	Topical	.0004 1/100mL
Oil	Topical
Solution	Topical
Cream	Topical	.01 g/25g
Patch	Topical	1 g/100g
Spray	Topical
Cream	Topical	.018 g/45mL
Cream	Topical	.012 g/30mL
Cream	Topical	.4 mg/g
Cream	Topical	.002 g/10g
Cream	Topical	.04 mL/mL
Lotion	Topical	.05 g/100mL
Cream	Topical	.05 g/100mL
Patch	Topical	.01 g/25mL
Liquid	Topical	.001 g/3mL
Patch	Topical	.009 g/24mL
Patch	Topical	.008 g/20mL
Liquid	Topical	.001 g/4mL
Lotion	Topical	1 mg/150mL
Liquid	Topical	.04 mL/100mL
Cream	Topical	.02 g/50g
Cream	Topical	.024 g/60g
Powder	Topical
Emulsion	Topical
Emulsion	Topical	.06 g/150mL
Liquid	Topical	.06 g/150mL

Prices

Unit description	Cost	Unit
Adenosine-5 monophosphate	19.74USD	g
Adenosine powder	15.86USD	g
Adenoscan 3 mg/ml vial	10.09USD	ml
Adenosine 12 mg/4 ml vial	8.44USD	ml
Adenosine 6 mg/2 ml vial	8.1USD	ml

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US5731296	No	1995-03-24	2015-03-24	US

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	235.5 °C	PhysProp
water solubility	8230 mg/L	Not Available
logP	-1.05	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
Water Solubility	14.0 mg/mL	ALOGPS
logP	-1.2	ALOGPS
logP	-2.1	ChemAxon
logS	-1.3	ALOGPS
pKa (Strongest Acidic)	12.45	ChemAxon
pKa (Strongest Basic)	4.99	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	139.54 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	63.2 m³·mol^-1	ChemAxon
Polarizability	25.27 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	+	0.9227
Blood Brain Barrier	+	0.9383
Caco-2 permeable	-	0.8957
P-glycoprotein substrate	Non-substrate	0.7026
P-glycoprotein inhibitor I	Non-inhibitor	0.966
P-glycoprotein inhibitor II	Non-inhibitor	0.9533
Renal organic cation transporter	Non-inhibitor	0.9444
CYP450 2C9 substrate	Non-substrate	0.8639
CYP450 2D6 substrate	Non-substrate	0.8349
CYP450 3A4 substrate	Non-substrate	0.5866
CYP450 1A2 substrate	Non-inhibitor	0.9667
CYP450 2C9 inhibitor	Non-inhibitor	0.9595
CYP450 2D6 inhibitor	Non-inhibitor	0.977
CYP450 2C19 inhibitor	Non-inhibitor	0.9514
CYP450 3A4 inhibitor	Non-inhibitor	0.962
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.9701
Ames test	Non AMES toxic	0.9133
Carcinogenicity	Non-carcinogens	0.9182
Biodegradation	Not ready biodegradable	0.9738
Rat acute toxicity	1.9715 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.989
hERG inhibition (predictor II)	Non-inhibitor	0.9102

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)

Download (9.12 KB)

Spectra

Spectrum Type	Description	Splash Key
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (4 TMS)	splash10-0f7w-1890000000-5c70a5423faa5e8eceaf	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (4 TMS)	splash10-001v-0691000000-8f88854b7d5adec5c558	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)	splash10-001s-0790000000-cc3bcd977e11efd4ea25	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (4 TMS)	splash10-00di-9460000000-3ae19bfaa5d2df72f9b1	View in MoNA
GC-MS	GC-MS Spectrum - GC-MS (3 TMS)	splash10-0gc0-0590000000-05874cecded3009c1f4d	View in MoNA
GC-MS	GC-MS Spectrum - GC-MS (4 TMS)	splash10-0fsv-1792000000-b37fd6826f28aaf9e825	View in MoNA
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS	Not Available
GC-MS	GC-MS Spectrum - GC-EI-TOF	splash10-0f7w-1890000000-5c70a5423faa5e8eceaf	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF	splash10-001v-0691000000-8f88854b7d5adec5c558	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF	splash10-001s-0790000000-cc3bcd977e11efd4ea25	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF	splash10-00di-9460000000-3ae19bfaa5d2df72f9b1	View in MoNA
GC-MS	GC-MS Spectrum - GC-MS	splash10-0gc0-0590000000-05874cecded3009c1f4d	View in MoNA
GC-MS	GC-MS Spectrum - GC-MS	splash10-0fsv-1792000000-b37fd6826f28aaf9e825	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-014r-0890000000-588861a9494ab4680698	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-000i-1900000000-dd7cbed8e76c6e783831	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-000i-2900000000-c6644520b5943b59403d	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-0090000000-3d4fd8ea211eaed10531	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-0900000000-cb58ec56a5faa09c9a02	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-0900000000-9559aa07ec13a688fb16	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-0900000000-f7c1371d8e1058df3a32	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-001i-0940000000-da71247788bf1ba222e2	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-001i-0920000000-f2e8ec028abdd674b5e3	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-001i-0910000000-815ed65588c07415cd65	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-001i-1910000000-2780e737da8848411c4f	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-053r-1900000000-c6c1128990661334c15b	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-014i-0090000000-106e7131507fadd4befb	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-000i-0910000000-1c53823486cd2c23f90e	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-000i-0900000000-f0313435db4847490fd6	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-000i-1900000000-dcd4c2972882dcd7535a	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-000i-2900000000-5ee474864189cef6df64	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positive	splash10-000i-0900000000-17edf36faf6eb5750912	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positive	splash10-000i-0900000000-0591143763a0bad31c23	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-014i-0290000000-f1d71a97ce39145c8e31	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Positive	splash10-00kr-0950000000-9bbdbb14aed287ad5ac8	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-001i-0910000000-35f90965f1f3c2b3236b	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-000i-0900000000-f360cca994696d7ae735	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available
1D NMR	1H NMR Spectrum	Not Available
1D NMR	13C NMR Spectrum	Not Available
2D NMR	[1H,1H] 2D NMR Spectrum	Not Available
2D NMR	[1H,13C] 2D NMR Spectrum	Not Available

Taxonomy

Description

This compound belongs to the class of organic compounds known as purine nucleosides. These are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Purine nucleosides

Sub Class

Not Available

Direct Parent

Purine nucleosides

Alternative Parents

Glycosylamines / Pentoses / 6-aminopurines / Aminopyrimidines and derivatives / N-substituted imidazoles / Imidolactams / Tetrahydrofurans / Heteroaromatic compounds / Secondary alcohols / Oxacyclic compounds

Substituents

Purine nucleoside / Glycosyl compound / N-glycosyl compound / 6-aminopurine / Pentose monosaccharide / Imidazopyrimidine / Purine / Aminopyrimidine / Monosaccharide / N-substituted imidazole

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

adenosines (CHEBI:16335 ) / Ribonucleosides (C00212 )

Targets

Details

1. Adenosine receptor A2a

Kind: Protein
Organism: Human
Pharmacological action: yes
Actions: agonist

General Function:: Identical protein binding
Specific Function:: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Gene Name:: ADORA2A
Uniprot ID:: P29274
Uniprot Name:: Adenosine receptor A2a
Molecular Weight:: 44706.925 Da

References

Trincavelli ML, Daniele S, Martini C: Adenosine receptors: what we know and what we are learning. Curr Top Med Chem. 2010;10(9):860-77. [PubMed:20370662 ]
Schenone S, Brullo C, Musumeci F, Bruno O, Botta M: A1 receptors ligands: past, present and future trends. Curr Top Med Chem. 2010;10(9):878-901. [PubMed:20370661 ]
Ezeamuzie CI, Khan I: The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages. Int Immunopharmacol. 2007 Apr;7(4):483-90. Epub 2006 Dec 29. [PubMed:17321471 ]
Kreckler LM, Wan TC, Ge ZD, Auchampach JA: Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor. J Pharmacol Exp Ther. 2006 Apr;317(1):172-80. Epub 2005 Dec 9. [PubMed:16339914 ]
Kreckler LM, Gizewski E, Wan TC, Auchampach JA: Adenosine suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production by murine macrophages through a protein kinase A- and exchange protein activated by cAMP-independent signaling pathway. J Pharmacol Exp Ther. 2009 Dec;331(3):1051-61. doi: 10.1124/jpet.109.157651. Epub 2009 Sep 11. [PubMed:19749080 ]
Buenestado A, Grassin Delyle S, Arnould I, Besnard F, Naline E, Blouquit-Laye S, Chapelier A, Bellamy JF, Devillier P: The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages. Br J Pharmacol. 2010 Mar;159(6):1304-11. doi: 10.1111/j.1476-5381.2009.00614.x. Epub 2010 Feb 5. [PubMed:20136829 ]
Funakoshi H, Zacharia LC, Tang Z, Zhang J, Lee LL, Good JC, Herrmann DE, Higuchi Y, Koch WJ, Jackson EK, Chan TO, Feldman AM: A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction. Circulation. 2007 May 1;115(17):2307-15. Epub 2007 Apr 16. [PubMed:17438146 ]
Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen JF, Bach FH, Otterbein LE: Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages. J Immunol. 2007 May 1;178(9):5921-9. [PubMed:17442976 ]

Details

2. Adenosine receptor A2b

Kind: Protein
Organism: Human
Pharmacological action: yes
Actions: agonist

General Function:: G-protein coupled adenosine receptor activity
Specific Function:: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Gene Name:: ADORA2B
Uniprot ID:: P29275
Uniprot Name:: Adenosine receptor A2b
Molecular Weight:: 36332.655 Da

References

Trincavelli ML, Daniele S, Martini C: Adenosine receptors: what we know and what we are learning. Curr Top Med Chem. 2010;10(9):860-77. [PubMed:20370662 ]
Schenone S, Brullo C, Musumeci F, Bruno O, Botta M: A1 receptors ligands: past, present and future trends. Curr Top Med Chem. 2010;10(9):878-901. [PubMed:20370661 ]
Ezeamuzie CI, Khan I: The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages. Int Immunopharmacol. 2007 Apr;7(4):483-90. Epub 2006 Dec 29. [PubMed:17321471 ]
Kreckler LM, Wan TC, Ge ZD, Auchampach JA: Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor. J Pharmacol Exp Ther. 2006 Apr;317(1):172-80. Epub 2005 Dec 9. [PubMed:16339914 ]
Buenestado A, Grassin Delyle S, Arnould I, Besnard F, Naline E, Blouquit-Laye S, Chapelier A, Bellamy JF, Devillier P: The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages. Br J Pharmacol. 2010 Mar;159(6):1304-11. doi: 10.1111/j.1476-5381.2009.00614.x. Epub 2010 Feb 5. [PubMed:20136829 ]
Funakoshi H, Zacharia LC, Tang Z, Zhang J, Lee LL, Good JC, Herrmann DE, Higuchi Y, Koch WJ, Jackson EK, Chan TO, Feldman AM: A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction. Circulation. 2007 May 1;115(17):2307-15. Epub 2007 Apr 16. [PubMed:17438146 ]
Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen JF, Bach FH, Otterbein LE: Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages. J Immunol. 2007 May 1;178(9):5921-9. [PubMed:17442976 ]

Details

3. Adenosine receptor A3

Kind: Protein
Organism: Human
Pharmacological action: yes
Actions: agonist

General Function:: G-protein coupled adenosine receptor activity
Specific Function:: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.
Gene Name:: ADORA3
Uniprot ID:: P0DMS8
Uniprot Name:: Adenosine receptor A3
Molecular Weight:: 36184.175 Da

References

Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Trincavelli ML, Daniele S, Martini C: Adenosine receptors: what we know and what we are learning. Curr Top Med Chem. 2010;10(9):860-77. [PubMed:20370662 ]
Schenone S, Brullo C, Musumeci F, Bruno O, Botta M: A1 receptors ligands: past, present and future trends. Curr Top Med Chem. 2010;10(9):878-901. [PubMed:20370661 ]
Ezeamuzie CI, Khan I: The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages. Int Immunopharmacol. 2007 Apr;7(4):483-90. Epub 2006 Dec 29. [PubMed:17321471 ]
Kreckler LM, Wan TC, Ge ZD, Auchampach JA: Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor. J Pharmacol Exp Ther. 2006 Apr;317(1):172-80. Epub 2005 Dec 9. [PubMed:16339914 ]
Buenestado A, Grassin Delyle S, Arnould I, Besnard F, Naline E, Blouquit-Laye S, Chapelier A, Bellamy JF, Devillier P: The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages. Br J Pharmacol. 2010 Mar;159(6):1304-11. doi: 10.1111/j.1476-5381.2009.00614.x. Epub 2010 Feb 5. [PubMed:20136829 ]
Funakoshi H, Zacharia LC, Tang Z, Zhang J, Lee LL, Good JC, Herrmann DE, Higuchi Y, Koch WJ, Jackson EK, Chan TO, Feldman AM: A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction. Circulation. 2007 May 1;115(17):2307-15. Epub 2007 Apr 16. [PubMed:17438146 ]
Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen JF, Bach FH, Otterbein LE: Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages. J Immunol. 2007 May 1;178(9):5921-9. [PubMed:17442976 ]

Details

4. Adenosine receptor A1

Kind: Protein
Organism: Human
Pharmacological action: yes
Actions: agonist

General Function:: Purine nucleoside binding
Specific Function:: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Gene Name:: ADORA1
Uniprot ID:: P30542
Uniprot Name:: Adenosine receptor A1
Molecular Weight:: 36511.325 Da

References

Trincavelli ML, Daniele S, Martini C: Adenosine receptors: what we know and what we are learning. Curr Top Med Chem. 2010;10(9):860-77. [PubMed:20370662 ]
Schenone S, Brullo C, Musumeci F, Bruno O, Botta M: A1 receptors ligands: past, present and future trends. Curr Top Med Chem. 2010;10(9):878-901. [PubMed:20370661 ]
Ezeamuzie CI, Khan I: The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages. Int Immunopharmacol. 2007 Apr;7(4):483-90. Epub 2006 Dec 29. [PubMed:17321471 ]
Buenestado A, Grassin Delyle S, Arnould I, Besnard F, Naline E, Blouquit-Laye S, Chapelier A, Bellamy JF, Devillier P: The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages. Br J Pharmacol. 2010 Mar;159(6):1304-11. doi: 10.1111/j.1476-5381.2009.00614.x. Epub 2010 Feb 5. [PubMed:20136829 ]
Funakoshi H, Zacharia LC, Tang Z, Zhang J, Lee LL, Good JC, Herrmann DE, Higuchi Y, Koch WJ, Jackson EK, Chan TO, Feldman AM: A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction. Circulation. 2007 May 1;115(17):2307-15. Epub 2007 Apr 16. [PubMed:17438146 ]
Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen JF, Bach FH, Otterbein LE: Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages. J Immunol. 2007 May 1;178(9):5921-9. [PubMed:17442976 ]

Enzymes

Details

1. Adenosine deaminase

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Zinc ion binding
Specific Function:: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.
Gene Name:: ADA
Uniprot ID:: P00813
Uniprot Name:: Adenosine deaminase
Molecular Weight:: 40764.13 Da

References

Kopff M, Kopff A, Puczkowski S: [Adenosine deaminase: isoenzymes ADA1 and ADA2]. Pol Merkur Lekarski. 1997 Dec;3(18):288-90. [PubMed:9523470 ]

Details

2. Adenosine kinase

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Poly(a) rna binding
Specific Function:: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Gene Name:: ADK
Uniprot ID:: P55263
Uniprot Name:: Adenosine kinase
Molecular Weight:: 40545.075 Da

References

Boison D: Adenosine kinase, epilepsy and stroke: mechanisms and therapies. Trends Pharmacol Sci. 2006 Dec;27(12):652-8. Epub 2006 Oct 23. [PubMed:17056128 ]

Transporters

Details

1. Solute carrier family 28 member 3

Kind: Protein
Organism: Human
Pharmacological action: unknown

General Function:: Pyrimidine- and adenine-specific:sodium symporter activity
Specific Function:: Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazaurid...
Gene Name:: SLC28A3
Uniprot ID:: Q9HAS3
Uniprot Name:: Solute carrier family 28 member 3
Molecular Weight:: 76929.61 Da

References

Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM: Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). Pharmacogenomics J. 2005;5(3):157-65. [PubMed:15738947 ]

Drug created on June 13, 2005 07:24 / Updated on September 01, 2017 10:30

Structure for DB00640 (Adenosine)

Targets

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Enzymes

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Transporters

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