Displaying drugs 301 - 325 of 11559 in total
N,N'-diphenyl-1,4-phenylenediamine
Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …
4-(Isopropylamino)diphenylamine
4-(Isopropylamino)diphenylamine, also known as IPPD, is a chemical compound commonly used as an antiozonant in rubbers, particularly those used for tires. It is also a known allergen. Sensitivity to this compound may be identified with a clinical patch test.
Approved
Experimental
Matched Description: … It is also a known allergen. ... Sensitivity to this compound may be identified with a clinical patch test. ... 4-(Isopropylamino)diphenylamine, also known as IPPD, is a chemical compound commonly used as an antiozonant …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Aminolevulinic acid
A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem]
Approved
Matched Description: … It is used as a photochemotherapy for actinic keratosis. [PubChem] ... A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. …
Polyvinyl alcohol
Polyvinyl alcohol is a water-soluble synthetic polymer obtained by polymerization of vinyl alcohol. It has varying roles in commercial and industrial applications such as papermaking, textiles, and printing. Polyvinyl alcohol is found in ophthalmic solutions as a lubricant to prevent irritation or to relieve dryness of the eyes .
Approved
Matched Description: … Polyvinyl alcohol is a water-soluble synthetic polymer obtained by polymerization of vinyl alcohol. ... Polyvinyl alcohol is found in ophthalmic solutions as a lubricant to prevent irritation or to relieve …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Aminoglutethimide
An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant properties. (From Martindale,...
Approved
Investigational
Matched Description: … An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of …
Fluorouracil
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Approved
Matched Description: … A pyrimidine analog that is an antineoplastic antimetabolite. …
Matched Categories: … Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index …
Matched Categories: … Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index …
Acetylcholine
A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases,...
Approved
Investigational
Matched Description: … A neurotransmitter. ... major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a …
Rosin
Rosin is a solid form of resin obtained from pines and other plants, mostly conifers. It is prepared from heating fresh liquid resin to vaporize the volatile liquid terpene components. Rosin is used in various commercial and industrial applications, including printing, lead-tin industry, and food production. In the pharmaceuticals, rosin...
Approved
Matched Description: … Rosin is a solid form of resin obtained from pines and other plants, mostly conifers. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Lauric acid
Lauric acid is an inexpensive, non-toxic and safe to handle compound often used in laboratory investigations of melting-point depression. Lauric acid is a solid at room temperature but melts easily in boiling water, so liquid lauric acid can be treated with various solutes and used to determine their molecular masses.
Approved
Experimental
Matched Description: … Lauric acid is a solid at room temperature but melts easily in boiling water, so liquid lauric acid can …
Zuranolone
Zuranolone is a neuroactive steroid that acts as a positive allosteric modulator of the GABAA receptors. Unlike other more common GABAA positive allosteric modulators on the market like benzodiazepines, zuranolone can modulate both synaptic and extrasynaptic GABAA conductance due to binding to a non-benzodiazepine site on the receptor.[A260776,A260786] Zuranolone was...
Approved
Experimental
Matched Iupac: … 1-{2-[(1S,3aS,3bR,5aR,7R,9aS,9bR,11aS)-7-hydroxy-7,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren …
Matched Description: … Zuranolone is a neuroactive steroid that acts as a positive allosteric modulator of the GABAAa pharmacological profile of a neuroactive steroid in ... to a non-benzodiazepine site on the receptor. …
Matched Categories: … Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator …
Matched Description: … Zuranolone is a neuroactive steroid that acts as a positive allosteric modulator of the GABAAa pharmacological profile of a neuroactive steroid in ... to a non-benzodiazepine site on the receptor. …
Matched Categories: … Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator …
Calcium carbimide
Calcium carbimide, sold as the citrate salt, is an alcohol-sensitizing agent. Its effects are similar to the drug disulfiram (Antabuse) in that it interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic product acetaldehyde. Calcium carbimide was conceived as an alternative for the treatment of...
Approved
Withdrawn
Matched Description: … Calcium carbimide was conceived as an alternative for the treatment of alcoholism with a reduced side …
Tranexamic acid
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent. It was first patented in 1957 and received its initial US approval in 1986.
Approved
Matched Description: … Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and ... It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent …
Pegloticase
Pegloticase is a porcine recombinant PEGylated uricase indicated for the treatment of chronic gout in adult patients that do not respond to other types of therapies. Pegloticase has a similar activity to rasburicase, an enzyme that metabolizes uric acid to allantoin. In gout patients treated with pegloticase, the conversion of...
Approved
Investigational
Matched Description: … [L42425]
Pegloticase has a longer terminal elimination half-life thanks to the addition of a polyethylene ... Pegloticase is a porcine recombinant PEGylated uricase indicated for the treatment of chronic gout in ... [A249980] The PEG group also gives pegloticase a lower potential to induce an immune response. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Polysorbate 20
Polysorbate 20 is a polysorbate-type nonionic surfactant used in many commercial, household and pharmaceutical products. It is composed of 20 repeated units of polyethylene glycol via ethoxylation. Polysorbate 20 is a wetting agent in food products, as well as washing agent, stabilizer and solubilizer in labratory assays and industrial applications....
Approved
Matched Description: … Polysorbate 20 is a polysorbate-type nonionic surfactant used in many commercial, household and pharmaceutical ... Polysorbate 20 is a wetting agent in food products, as well as washing agent, stabilizer and solubilizer …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Poloxamer 188
Poloxamer 188 (P188) is a nonionic block linear copolymer that exhibits rheologic, anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models . Composed of two hydrophilic side-chains attached to a hydrophobic center core , its average molecular weight is 8400 Daltons. P188 was originally approved by the FDA in...
Approved
Investigational
Matched Description: … P188 was originally approved by the FDA in the 1960s as a therapeutic agent to reduce viscosity in the ... The ability of P188 in attenuating membrane damage and cell injury has been demonstrated in a variety ... Poloxamer 188 (P188) is a nonionic block linear copolymer that exhibits rheologic, anti-thrombotic, anti-inflammatory …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Cefotiam
One of the cephalosporins that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.
Approved
Investigational
Matched Description: … One of the cephalosporins that has a broad spectrum of activity against both gram-positive and gram-negative …
gamma-Aminobutyric acid
The most common inhibitory neurotransmitter in the central nervous system.
Approved
Investigational
Tolvaptan
Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009.
Approved
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Ofloxacin
A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Approved
Matched Description: … A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity …
Obeticholic acid
Primary biliary cirrhosis, or PBC, is a progressive and chronic condition that leads to hepatic injury often resulting in end-stage liver failure that requires liver transplantation. Obeticholic acid is a farnesoid-X receptor (FXR) agonist used to treat this condition, possibly allowing for increased survival. In 2016, it was granted approval...
Approved
Matched Iupac: … 3aS,3bS,4R,5R,5aS,7R,9aS,9bS,11aR)-5-ethyl-4,7-dihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a] …
Matched Description: … Primary biliary cirrhosis, or PBC, is a progressive and chronic condition that leads to hepatic injury ... [A192786] Obeticholic acid is a farnesoid-X receptor (FXR) agonist used to treat this condition, possibly ... with PBC and advanced cirrhosis (e.g. those with portal hypertension or hepatic decompensation) due to a …
Matched Description: … Primary biliary cirrhosis, or PBC, is a progressive and chronic condition that leads to hepatic injury ... [A192786] Obeticholic acid is a farnesoid-X receptor (FXR) agonist used to treat this condition, possibly ... with PBC and advanced cirrhosis (e.g. those with portal hypertension or hepatic decompensation) due to a …
Pazopanib
Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Approved
Matched Description: … Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Calaspargase pegol
Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparaginase treatment...
Approved
Matched Description: … part of a multi-agent chemotherapy regimen for the treatment of ALL [L4890]. ... of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a ... Calaspargase pegol, also known as _asparlas_, is an asparagine specific enzyme which is indicated as a …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Exemestane
Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition.
Approved
Investigational
Matched Iupac: … 9aR,9bS,11aS)-9a,11a-dimethyl-5-methylidene-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Paliperidone
Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin...
Approved
Matched Iupac: … [4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a] …
Matched Description: … intramuscular injection, and a twice-yearly gluteal injection. ... The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. ... It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination …
Matched Description: … intramuscular injection, and a twice-yearly gluteal injection. ... The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. ... It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination …
Acetylsalicylic acid
Also known as Aspirin, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction...
Approved
Vet approved
Matched Description: … Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain ... Acetylsalicylic acid is a very common cause of accidental poisoning in young children. ... Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available …
Matched Mixtures name: … A & C Tablets With Codeine 30mg ... A & C Tablets With Codeine 15mg ... KLOGEL-A 75/75 MG KAPSUL, 30 ADET …
Matched Mixtures name: … A & C Tablets With Codeine 30mg ... A & C Tablets With Codeine 15mg ... KLOGEL-A 75/75 MG KAPSUL, 30 ADET …
Displaying drugs 301 - 325 of 11559 in total